Biomedical  Basics-­‐Technological  Developments-­‐Medical  Implementa4on    

Research  for  Health  

BioTechMed-­‐Graz  

•  Inter-­‐university  research  ac;vi;es  of  high  biomedical  relevance:  –  Lipid-­‐  and  energy  metabolism  –  Lipid-­‐associated  and  cardiovascular  diseases,  and  inflamma;on  –  Infec;on  biology  and  the  development  of  novel  an;bio;cs  –  Microbiome  and  genome  research  –  Tumor  biology  and  metabolism  –  Neurodegenera;ve  diseases  and  the  molecular  basis  of  ageing  

 

Molecular  Biomedicine  

2  

Sepp.kohlwein@uni-graz.at

•  Inter-­‐university  research  ac;vi;es  of  high  biomedical  relevance:  –  Lipid-­‐  and  energy  metabolism  –  Lipid-­‐associated  and  cardiovascular  diseases,  and  inflamma;on  –  Infec;on  biology  and  the  development  of  novel  an;bio;cs  –  Microbiome  and  genome  research  –  Tumor  biology  and  metabolism  –  Neurodegenera;ve  diseases  and  the  molecular  basis  of  ageing  

 

Molecular  Biomedicine  

3  

Kohlwein  (IMB,  KFU);  Berg  (IEBT,  TUG);  Höfler  (Patho,  MUG)  Moissl-­‐Eichinger  (Int.Med.,  MUG)  

 

   

Av.$Number$of$Personnel

0 2.5$Mio

1 0.9$Mio

27 4.3$Mio

36 4.8$Mio $$

204 1.5$Mio

20030 9.8$Mio

00 7.1$Mio

00

45 11.5$Mio

20030 11.1$Mio

600120 91$Mio

30 8.7$Mio

30 8.9$Mio

2020

Grant$Volume$Approved

Wittgenstein

Project$Duration

2015

Kplus$a?b

Leducq

ERC$Grant

SFB$Biomembranes

SFB$Biocatalysis

GOLD$I$?$III

DK$Molin

DK$Molecular$Enzymology

1995 2000 2005 2010

COMET$K2:$ACIB

DK$MCD$

SFB$MOBIS

INGE.St

SFB$LIPOTOX

NANO?Health

Core facility Molekularbiologie

Core facility MS – Proteomics & Lipidomics

Integrated  projects  –  past  and  future...  

CB-­‐Med   25  Mio  

   

Av.$Number$of$Personnel

0 2.5$Mio

1 0.9$Mio

27 4.3$Mio

36 4.8$Mio $$

204 1.5$Mio

20030 9.8$Mio

00 7.1$Mio

00

45 11.5$Mio

20030 11.1$Mio

600120 91$Mio

30 8.7$Mio

30 8.9$Mio

2020

Grant$Volume$Approved

Wittgenstein

Project$Duration

2015

Kplus$a?b

Leducq

ERC$Grant

SFB$Biomembranes

SFB$Biocatalysis

GOLD$I$?$III

DK$Molin

DK$Molecular$Enzymology

1995 2000 2005 2010

COMET$K2:$ACIB

DK$MCD$

SFB$MOBIS

INGE.St

SFB$LIPOTOX

NANO?Health

Core facility Molekularbiologie

Core facility MS – Proteomics & Lipidomics

Integrated  projects  –  past  and  future...  

CB-­‐Med  

•  Mul;ple  na;onal  and  interna;onal  research  programs  •  Local  ongoing  research  networks  

–  SFB  LIPOTOX  (KFU,  MUG,  TUG;  2007-­‐)  –  DK  Molecular  Enzymology  –  DK  MOLIN  –  DK  Metabolic  and  Cardiovascular  Disease  –  K1  Competence  Center  CB-­‐Med  –  ACIB  

•  Interna;onal  coopera;ons  –  Joint  programmes  w/Singapore  (NUS,  Duke-­‐NUS,  SBIC)  in  prepara4on  –  EuroBioimaging  in  prepara4on  

 

Molecular  Biomedicine  

6  

•  ZMF,  OMICS  Center  (MUG,  KFU,  TUG)  –  Imaging,  ultrastructure  analysis  (confocal,  mul;photon,  electron  microscopy)  –  Mass  spectrometry  (proteomics,  lipidomics)  –  Transcriptomics,  NextGen  sequencing  –  Bioinforma;cs,  Structural  Biology,  Biophysics  –  Clinical  Research  Center  

•  NIKON  Center  of  Excellence  (MUG,  KFU)  –  Super-­‐resolu;on  microscopy  

•  NAWI  Graz  –  Central  Lab  Core  Facili;es  –  FACS  Center  GRACIA  

•  Core  Facility  Net    

Infrastructure  

7  

     

Infrastructure  

8  

hfp://zmf.medunigraz.at/  

hfp://omicscentergraz.at/  

hfp://bioimaginggraz.at  

hfp://www.nawigraz.at/de/research/infrastruktur/central-­‐labscore-­‐facili;es/  

hfps://corefacilitynet.org/share/page/site/core-­‐facility-­‐net/dashboard  

 

•  We are microbes.

Molecular  Biomedicine  

9  

C.  Moissl-­‐Eichinger  Prof.  for  Interac;ve  Microbiome  research  

Environment

•  Flagship  project:        

 Interac2ve    Microbiome    research  

 •  Why  is  microbiome  research  

so  important?  

•  Why  do  we  need  new  (interdisciplinary)  approaches  and  the  view  beyond?  

•  How  can  it  bring  different  research  disciplines  together?  

 

 

•  MIGRobeZ:  Mikrobiomini;a;ve  Graz  •  Collabora;on  of  microbiome  researches    

 from  all  BioTechMed  universi;es  •  Provide  standards,  procedures/  Infrastructures  •  Joint  publica;ons  and  acquisi;on  of  funding  

•  Our  ques;ons  for  the  future:  •  Bacteria  and  beyond?  •  Increase  the  efficiency  of  microbial  cul;va;on?  •  How  can  we  „control“  the  microbiome?  Interac;on  of  the  microbiomes?  •  How  does  the  microbiome  influence  our  health,  behaviour,  well-­‐being?  •  How  can  we  influence  the  microbiome?  •  …  

•  Seeking   for   collabora;on   partners   with   new,   interdisciplinary   ideas   …   and  ques;ons!  Imaging/  modelling/  microbe  tracking/  method  development:  quan;fica;on/  func;on…  

Interac;ve  Microbiome  Research  

10  

Molecular  &  Technical  

Biosciences,  Biomedicine  

Pharmazeu2cal  and  Medical  Technology  

OMICS-­‐CENTER  

BIOIMAGING   MR-­‐UPGRADE  Neurosciences  

Quan2ta2ve  Biomedicine,  

Biomechanics  &  Modelling  

Interac;ons    

Post  Docs  Technical  Staff  

BioTechMed-­‐Graz  

•  Stronger  involvement  of  the  Technical  Biosciences  

–  Molecular  Biotechnology,  TUG  

–  ACIB  (Industry)  

•  Befer  tech  support  –  Personnel  (infrastructure  without  personnel  support  =  waste  of  money)  

–  Relief  from  administra;ve  work  

•  More  Room  for  Research  

What  is  missing...  

12  

 

Biomedical  Basics-­‐Technological  Developments-­‐Medical  Implementa4on    

Research  for  Health  

BioTechMed-­‐Graz