Biotechnological Research under Horizon 2020

Deutsche Biotechnologietage 2014

Hamburg, 09 April 2014

1) Enhance competitiveness of EU industries and create additional highly-skilled jobs

• building competitive bio-based industries and value chains in the EU

2) Moving to a low carbon economy

• Reducing GHG emissions

• 'Cascading principle' and 'Closing the loops'

3) Re-instate economic growth in rural areas

• Sustainable valorisation of all resources (edible/non-edible) from agriculture and forestry

4) Increase independence from fossil resources

• Utilising alternative resources

5) Raising the contribution of industry to EU GDP to 20% by 2020

Main EU policy goals reflected in Horizon 2020

EU 2030 emission reduction targets (as of February 2014)

CO2 emission reduction: 40%

Share of renewable energy in the EU: 27%

Rough estimate for EU industry: - 300 mio t CO2 by 2030

• The potential contribution of IB to Gross Value Added to date is in the 50-60 billion € range globally; it is estimated to total 300 billion € by 2030

• Europe is the world leading producer of enzymes (75%)

• Europe is heading the implementation of Industrial Biotechnology (IB) for fine chemicals

• Nearly 70% of the IB's R&D expenditure by leading companies worldwide spent by European firms

• Worldwide, industrial biotechnology is in the focus!

• Pike Research: almost 1800 biorefineries to be commissioned globally until 2022 (e.g. US, Brazil, China, Malaysia, India, Thailand)

• $ 1.4 billion of public funding was allocated to the development of advanced biofuels in the US in 2011;

The EU: Industrial leadership in biotechnology

Biotechnology today: opportunities for jobs and growth

• ● The example of the EU Chemical Industry

• - in 2020 combined sales of € 491 billion, € 50 billion or 10% thereof bio-based;

• - bio-based chemicals share expected to rise until 2030 to 30% of sales (thus € 150 billion annual sales, affecting up to 400.000 jobs)

• - Technology leadership in support of competitiveness will be instrumental for securing a high market share of EU industries and EU jobs.

• ● And EU Agriculture and Forestry?

• - Feedstock costs in biorefineries typically 25-40% of final product value;

• - Estimated additional € 100 billion bio-based products in the chemical industry would represent an additional market value of € 25 billion for biomass production and logistics in the EU

Potential for EU regions in bio-based industries

© Dalberg Study 2011

Source: Prof Dr.-Ing Christian Paulik, Johannes Kepler University Linz

The biomass issue: an example from an agricultural perspective

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World market prices per mt as of Feb 2014: Crude oil € 550; Sugar € 350 – 400; Straw € 50 - 100

Positive effects realised due to biotechnology/ biochemistry replacing conventional processes

• Vitamin B2 production: 1 fermentation process replaced an 8-step combined chemical-biotechnological synthesis route; 7 solvents made redundant, waste reduction 75%, cost reduction 20%.

• Cephalexin antibiotic: 13 chemical steps replaced by 1 fermentative and 2 enzymatic steps; 65% less energy and materials, 50% lower costs.

• Captopril: ACE inhibitor to treat high-blood pressure. Building blocks D-b-hydroxy-isobutyric acid and L-proline synthesized by fermentation, and linked by conventional chemistry.

• PLA: One-step fermentation replaces chemical/catalytic polymerisation of other plastics, such as HDPE, LDPE etc. Depending on which plastic is replaced, PLA can reduce emissions by up to 80%, water consumption by up to 90%, and eliminates the use of solvents in the process. In comparison to conventional polymers, PLA is biodegradable!

Source: NREL 2004 The value added chemicals from biomass volume 1

Overview biochemical synthesis, non-exhaustive

Main current challenges

• Improving overall process sustainability

• Alternative inputs (e.g. food waste), increasing energy efficiency, reducing required process steps

• Product yields

• Genetic engineering for strain optimization

• Cultivation inputs and conditions

• Product recovery

• More energy efficient processes

• Contineous batch production

• Product quality

• Aim for 100% product purity

And

• Expanding the portfolio: new technologies, products and product functionalities

• New microbes, metabolic pathways and new enzymes

FP7 KBBE ~ € 650 mio

Novel sources of biomass and bioproducts

Marine and fresh-water biotechnology

Biorefinery

Societal challenge 2

Food security, sustainable agriculture, marine and maritime research and the bioeconomy

•JTI

•Marine biotechnology research

Environmental biotechnology

Emerging trends in biotechnology

Industrial biotechnology

LEIT Biotechnology

• Biotechnology-based industrial processes, including environmental biotechnology

• Boosting cutting-edge biotechnologies as future innovation drivers

• Innovative and competitive platform technologies

NEW

Horizon 2020 > € 1500 mio

• Biotechnology-based industrial processes driving competitiveness and sustainability

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Aim: Maintain European leadership in industrial and environmental biotechnology.

Biocatalysts and bio-processing: bioprospecting, optimization of biocatalysts and biocatalytic process design

Novel and improved microorganisms: understanding gene expression in the light of stress conditions; understanding mixed cultures and the dynamics of microbial communities

Bioreactors and downstream processing: address possible bottlenecks in downstream processing and facilitate the transfer of new developments into operational environments

Environmental biotechnology: focussing on the development and practical use of know-how in terms of bioprospecting; biodetection of environmental pollution; bioremediation

• Cutting-edge biotechnologies as future innovation drivers

Aim: Assuring that the European industry stays at the forefront of

innovation, also in the medium and long term

Synthetic biology: creation of minimal cells, design of robust and sustainable bio-molecular circuits and pathways, biosafety and bioethics

Systems biology: investigating the operations of biological systems in order to optimize industrial applications of biotechnology

Bioinformatics: provision of powerful tools to store, retrieve and analyse biological data, in support of modelling and process design

Nano-biotechnology: combining both fields of research for application development in a wide range of sectors, biosafety and bioethics

Biotechnology in ICT: provision of ICT-devices incorporating biological materials

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• Innovative and competitive platform technologies

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Aim: Develop platform biotechnologies for a wide range of sectors in support of industrial leadership.

Platform technologies: Development of platform technologies and their integration across applications in support of the commercial use of biotechnology

Industrial applications of 'omics': Bringing closer to the market 'omics'-derived industrial applications, including prototyping and demonstration

PPPs in Horizon 2020

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Joint Technology Initiatives Contractual PPPs

• Innovative Medicines (IMI)

• Clean Sky

• Single European Sky ATM Research (SESAR)

• Fuel Cells and Hydrogen (FCH)

• Electronic Components and Systems (ECSEL - old ARTEMIS + ENIAC)

New:

• Bio-based Industries (BBI)

• Factory of the Future (FoF)

• Energy-efficient Buildings (EeB)

• Green Vehicles (EGVI)

• Future internet (5G)

New:

• Sustainable Process Industry (SPIRE)

• Robotics

• Photonics

• High Performance Computing

• Value Chain 1: From lignocellulosic feedstock to advanced biofuels, bio-based

chemicals and biomaterials: realising the feedstock and technology base for the

next generation of fuels, chemicals and materials

• Value Chain 2: The next generation forest-based value chains: utilisation of the

full potential of forestry biomass by improved mobilisation and realisation of new

added value products and markets

• Value Chain 3: The next generation agro-based value chains: realising the

highest sustainability and added value by improved agricultural production, and new

added value products and markets

• Value Chain 4: Emergence of new value chains from (organic) waste: from waste

problems to economic opportunities by realising sustainable technologies to convert

waste into valuable products

• Value Chain 5: The integrated energy, pulp and chemicals biorefineries:

realising sustainable bio-energy production, by backwards integration with biorefinery

operations isolating higher added value components

The strategic research agenda of the BBI JTI

http://biconsortium.eu/sites/default/files/downloads/BIC_SIRA_web.pdf

LEIT and SPIRE support the full value chain of the PROCESS industry

From Base Chemicals and Fuels over new Carbon

Nanotubes, Nano-structured Catalysts, new Chemical Pathways to Hybrid Materials for

Membranes, Electronics and Lighting as well as New Process Technologies, Structural

Materials for Manufacturing and Construction and Business Models.

Thank you for your attention!

Jens.Hoegel@ec.europa.eu

Horizon2020: ec.europa.eu/research/horizon2020 Participant Portal (calls, experts, projects): ec.europa.eu/research/participants/portal/page/home Public-Private Partnership on bio-based industries: http://biconsortium.eu/