biotechnology in iran - pharmaceutical manufacturing · 3 biotechnology in iran products in the...
TRANSCRIPT
Biotechnology in Biotechnology in the Islamic Republic the Islamic Republic
of Iranof Iran
2
Main Institutes involved in Main Institutes involved in BiotechnologyBiotechnology
National Institute for Genetic Engineering and National Institute for Genetic Engineering and Biotechnology Biotechnology Pasteur Institute of IranPasteur Institute of IranRaziRazi Institute for Vaccine developmentInstitute for Vaccine developmentSharifSharif UniversityUniversityPersian Golf Biotechnology Research centerPersian Golf Biotechnology Research centerTarbiateTarbiate ModarresModarres UniversityUniversityOther Universities (Tehran, Shiraz, Other Universities (Tehran, Shiraz, MashhadMashhad, , TabrizTabrizand and IsfahanIsfahan))Agriculture Biotechnology Research CenterAgriculture Biotechnology Research Center
3
Biotechnology in IRANBiotechnology in IRAN
5858Products in the MarketProducts in the Market55Policy Maker Committees Policy Maker Committees 44Scientific SocietiesScientific Societies1010Private Companies (Material)Private Companies (Material)1515Private Companies (Equipments)Private Companies (Equipments)4242UniversitiesUniversities3535Research InstitutesResearch Institutes
NumberNumberTitleTitle
4
NGOs Involved in BiotechnologyNGOs Involved in Biotechnology
Iranian Society for Biotechnology (ISB), Iranian Society for Biotechnology (ISB), established 1997, 600 members, four branches in established 1997, 600 members, four branches in different provincesdifferent provincesIranian Genetic Society (IGS), established 2001, Iranian Genetic Society (IGS), established 2001, 500 Members500 MembersIranian Iranian BiosafetyBiosafety Society (IBS), established 2003, Society (IBS), established 2003, 150 members150 membersEthics Society In Science and Technology (ESST), Ethics Society In Science and Technology (ESST), established 2004established 2004Biotechnology Private Companies, total No. 25Biotechnology Private Companies, total No. 25
5
Education in BiotechnologyEducation in Biotechnology
55Medical & Intellectual Medical & Intellectual Property RightProperty Right
99Industrial BiotechnologyIndustrial Biotechnology
1111Agriculture BiotechnologyAgriculture Biotechnology
88Molecular Biology and Molecular Biology and GeneticGenetic
Total 35Total 35(PhD 14 & (PhD 14 & MScMSc 19)19)
Educational Programs Educational Programs
NumberNumberTitleTitle
6
Biotechnology Human ResourcesBiotechnology Human Resources
TotalTotal
Universities Universities (42)(42)
Research Research Centers (35)Centers (35)
RaziRaziInstituteInstitute
Pasture Pasture InstituteInstitute
NIGEBNIGEB
InstituteInstitute
755755
300300
233233
4747
1291294646
PhD PhD ResearchersResearchers
572572
133133
241241
108108
59593131
MScMScResearchersResearchers
653653
480480
139139
1010
24242525
Capacity for Capacity for Training Training PhD/yearPhD/year
11031103
871871
9797
3030
30307575
Capacity for Capacity for Training Training MScMSc/year/year
7
Research Capacities in BiotechnologyResearch Capacities in Biotechnology
TotalTotal
Universities (42)Universities (42)
Research Research Centers (35)Centers (35)
RaziRazi InstituteInstitute
Pasture InstitutePasture Institute
NIGEBNIGEB
InstituteInstitute
12128080815815
221212478478
556363300300
111155
11112222
33331010
Gene or Cell Gene or Cell BankBank
Animal or Animal or Green HouseGreen House
LaboratoriesLaboratories
8
Research Projects in BiotechnologyResearch Projects in Biotechnology
2011201114511451560560TotalTotal
326326226226100100Basic ScienceBasic Science
572572432432140140Industry & Industry & EnvironmentEnvironment
470470360360110110MedicalMedical643643433433210210AgricultureAgriculture
TotalTotalFinalized Finalized Projects Projects
Projects in Projects in DemandDemand
SubjectSubject
9
International Value of Biological International Value of Biological Products (per year)Products (per year)
794.1794.1248248TotalTotal
64642020PharmacutPharmacut. . CompaniesCompanies
Antibiotics (217 Antibiotics (217 tones/year)tones/year)
89.689.62828Pasture Inst.Pasture Inst.Vaccine, serum and Vaccine, serum and Cell CultureCell Culture
585585182.8182.8RaziRazi Inst.Inst.Vaccine & Serum Vaccine & Serum for Animalfor Animal
55.555.517.217.2RaziRazi Inst.Inst.Vaccine & Serum Vaccine & Serum for humanfor human
Private Market Private Market Price (million $)Price (million $)
UNICEF Price UNICEF Price (million $)(million $)
ProducerProducerProductProduct
10
Biotechnology Equipments Biotechnology Equipments
Cold and Hot roomCold and Hot roomPress FiltersPress FiltersFreezer (Freezer (--70oC)70oC)
CrystallizerCrystallizer
EvaporatorEvaporatorNitrogen TankNitrogen TankSpray DryerSpray Dryer
Trans LaminatorTrans LaminatorNameName
Private Co. Private Co. Kara Kara SanatSanat Co. Co. JallJall Co.Co.
Jihad Research Co.Jihad Research Co.
Jihad Research Co.Jihad Research Co.RahamRaham GazGaz Co. Co. Iran Iran KhoshkKhoshk Co.Co.
CadoosCadoos SepandSepand Co. Co. ProducerProducer
5000 $/Sq. meter5000 $/Sq. meter5,000 $5,000 $5,000 $5,000 $
20.000 $20.000 $
20,000 $20,000 $10,000 $10,000 $20,000 $20,000 $
500 $500 $Price Per UnitPrice Per Unit
11
Biotechnology Equipments Biotechnology Equipments
2000 $2000 $Pars Pars tebteb, , Laminar FellowLaminar Fellow
12000 $12000 $IROSTIROSTClean Steam Pro.Clean Steam Pro.
1000 $/ Sq. meter1000 $/ Sq. meterBesatBesat & Tehran & Tehran SakkooSakkoo Co.Co.
Clean RoomClean Room
>9000 $>9000 $IROST & Private IROST & Private Co.Co.
FermentorsFermentors (20 (20 10,000 liters)10,000 liters)
5000 $5000 $JallJall Co. Co. Shaker IncubatorShaker Incubator
500 $500 $PayaPaya pajooheshpajoohesh Co.Co.ElectrophoresisElectrophoresis
2000 $2000 $JaheshJahesh TebTeb Co.Co.Spectrophotometer Spectrophotometer (Visible)(Visible)
Price Per UnitPrice Per UnitProducerProducerNameName
12
Chemical and Food ProductsChemical and Food Products
--29,78029,780Citric acidCitric acid
525211,13711,137YeastYeast
0.90.9500500Vinegar form apple Vinegar form apple
--4,7004,700Protein for Feed Protein for Feed from molassesfrom molasses
40401,8901,890Ethanol from Ethanol from molassesmolasses
Value (million $)Value (million $)Capacity Capacity (tones/year)(tones/year)
ProductProduct
13
Biotechnology prioritiesBiotechnology prioritiesMolecular detection of infectious and genetic Molecular detection of infectious and genetic diseasesdiseasesProduction of Recombinant medicines and Production of Recombinant medicines and vvaccines accines BioremediationBioremediationBioinformaticsBioinformatics, , BisafetyBisafety and Bioethicsand BioethicsTransgenic plants Resistance to Biotic and Transgenic plants Resistance to Biotic and Abiotic StressAbiotic StressHuman Genome DiversityHuman Genome DiversityBioleaching of CooperBioleaching of CooperOil desulphurizationOil desulphurizationPrivatization of Biotechnology Industry Privatization of Biotechnology Industry
14
Biotechnology PolicyBiotechnology Policy
National Biotechnology Committee at National Biotechnology Committee at Ministry of Science, Research and Ministry of Science, Research and Technology Technology National Strategic plan of BiotechnologyNational Strategic plan of BiotechnologyBiotechnology Committees at Ministry of Biotechnology Committees at Ministry of Industry and Mine, Ministry of Health, Industry and Mine, Ministry of Health, Ministry of Agricultural jihad, Ministry of Agricultural jihad, Department of Environment protectionDepartment of Environment protection
15Tehran, Islamic Republic of Iran
National Institute for Genetic Engineering and Biotechnology
Established at 1989
Under the Supervision of The
Ministry of Science, Research and Technology
Scope:Plant, Animal, Medical and Marine, Industrial and Environmental Biotechnology
16
National Institute for Genetic Engineering National Institute for Genetic Engineering and Biotechnology (NIGEB)and Biotechnology (NIGEB)
Aims:Aims:Research activities in the field of advanced Research activities in the field of advanced
molecular biology & biotechnologymolecular biology & biotechnologyPromoting applied and basic research in Promoting applied and basic research in
science and technologyscience and technologyTechnology production in different field of Technology production in different field of
biotechnologybiotechnology
17
PatentsPatentsGenes Submitted at Gene Bank Genes Submitted at Gene Bank
16162727
Article Presented at National & Article Presented at National & Int. SeminarsInt. Seminars
612 612
Full Research PapersFull Research PapersBooksBooks
115 115 2424
Total No. of TechnologiesTotal No. of TechnologiesNo. Transferred to IndustryNo. Transferred to Industry
393955
National & International National & International CongressesCongresses
55
WorkshopsWorkshopsNo. of Trained ParticipantsNo. of Trained Participants
4747847847
NIGEB ResultsNIGEB Results
18
RaziRazi is one of the oldest and most important is one of the oldest and most important applied R&D organization in Iran.applied R&D organization in Iran.RaziRazi produces over 2.5 billion doses of 55 different produces over 2.5 billion doses of 55 different biological products, including human and biological products, including human and veterinary vaccines and also diagnostic antigens, at veterinary vaccines and also diagnostic antigens, at an annual value of about $105m.an annual value of about $105m.RaziRazi has 28 different departments and employs has 28 different departments and employs 1250 staff, including 133 scientists.1250 staff, including 133 scientists.The institute uses locally produced fermenters for The institute uses locally produced fermenters for vaccine production.vaccine production.RaziRazi has links to the WHO and is part of the UN has links to the WHO and is part of the UN health care infrastructure. health care infrastructure.
RaziRazi Vaccine & Serum Research Vaccine & Serum Research Institute Institute (1925)(1925)
19
List of products of List of products of RaziRazi InstituteInstitute
Vaccines for medical use Vaccines for medical use Sera for Therapeutic medical useSera for Therapeutic medical useVaccines for Veterinary use Vaccines for Veterinary use Veterinary Veterinary antiparasiticantiparasitic drugs drugs Antigens and other biological productsAntigens and other biological productsLaboratory animals Laboratory animals Herbal medicinal products Herbal medicinal products Other biotechnological productsOther biotechnological products
20
Medical VaccinesMedical VaccinesTetanus vaccine Tetanus vaccine Combined Diphtheria and Tetanus vaccine for children Combined Diphtheria and Tetanus vaccine for children Combined Diphtheria and Tetanus vaccine for adults Combined Diphtheria and Tetanus vaccine for adults Combined Diphtheria, Tetanus and Combined Diphtheria, Tetanus and PertusisPertusis vaccine vaccine (DTP)(DTP)Measles vaccineMeasles vaccineRubella vaccine Rubella vaccine Mumps vaccine Mumps vaccine Combined Measles, Rubella and Mumps vaccine Combined Measles, Rubella and Mumps vaccine (MMR)(MMR)Poliomyelitis vaccinePoliomyelitis vaccine
21
Molecular MedicineMolecular MedicinePrenatal Diagnostic for the following genetic Disorders:Prenatal Diagnostic for the following genetic Disorders:
Beta Beta ThelassemiaThelassemiaHemophiliaHemophiliaMuscular DystrophyMuscular Dystrophy
Molecular Diagnostic tests includingMolecular Diagnostic tests includingTBTBHCVHCVHBVHBVH.pyloriH.pyloriCMVCMVLeishmaniasisLeishmaniasisToxoplasmosisToxoplasmosis
22
Recombinant ProductsRecombinant ProductsHepatitis B VaccineHepatitis B VaccineStreptokinaseStreptokinaseInterferon AlphaInterferon AlphaInterferon GammaInterferon GammaGG--CSF & GMCSF & GM--CSFCSFHIV diagnostic KitsHIV diagnostic KitsHCV diagnostic KitsHCV diagnostic KitsHBS diagnostic kitsHBS diagnostic kitsHTLVHTLV--I, III, IIHuman Growth HormoneHuman Growth HormoneBlood group typing (Blood group typing (mAbmAb))Molecular Diagnostic kits for Infectious DiseasesMolecular Diagnostic kits for Infectious Diseases
23
Medical Therapeutic SeraMedical Therapeutic Sera
AntitetanicAntitetanic Serum Serum AntidiphthericAntidiphtheric Serum Serum Polyvalent Scorpion Polyvalent Scorpion AntivenumAntivenumPolyvalent Snake Polyvalent Snake AntivenumAntivenum
24
Biological ProductsBiological Products
Rabbit SerumRabbit SerumRabbit Plasma Rabbit Plasma Rabbit Complement Rabbit Complement Haemolyzin Haemolyzin Guinea Pig Serum Guinea Pig Serum Guinea Pig ComplementGuinea Pig ComplementMouse SerumMouse SerumRat SerumRat Serum
25
Herbal Medicinal ProductsHerbal Medicinal Products
Herb ExtractsHerb ExtractsEssential OilsEssential OilsActive Constituent of Eucalyptus i.e. 1.8Active Constituent of Eucalyptus i.e. 1.8CineoleCineole ((EucalyptotEucalyptot))
26
Other Biotechnology ProductsOther Biotechnology Products
BilirubinBilirubin Standard Standard F ANA Glass Slides F ANA Glass Slides Lectin Lectin Cholesterol KitCholesterol KitGlucose Kit Glucose Kit PeroxidasePeroxidase EnzymeEnzymeAnti Human Anti Human Polyvalent and Polyvalent and MonovalentMonovalent AntiseraAntisera for Salmonella for Salmonella Groups A, B, C and Groups A, B, C and TxphiTxphiAnimal Animal AntiseraAntisera and and ImmunoglobulinsImmunoglobulinsAnti Malaria Biological product Anti Malaria Biological product
27
PasteurPasteur Institute of Iran Institute of Iran (1920)(1920)
–– A primary center for research on infectious diseasesA primary center for research on infectious diseases–– A center for production of biological products, vaccines, and A center for production of biological products, vaccines, and
serums.serums.
Biotechnology DepartmentBiotechnology Department (1993)(1993)
–– The goal is conducting biotechnologyThe goal is conducting biotechnology-- related researchrelated research
Research Activities:Research Activities:
–– Molecular diagnostics:Molecular diagnostics: include molecular detection of include molecular detection of prevalent genetic disorders and various infectious diseases.prevalent genetic disorders and various infectious diseases.
–– Recombinant DNA technology: includes developmentRecombinant DNA technology: includes development of of recombinant vaccines and pharmaceutics. recombinant vaccines and pharmaceutics.
28
Iranian Research Organization for Science Iranian Research Organization for Science &Technology (IROST)&Technology (IROST) (1979)(1979)
IROST is affiliated with the Ministry of Science, IROST is affiliated with the Ministry of Science, Research and Technology.Research and Technology.Biotechnology Department:Biotechnology Department:
Persian Type Culture Collection (PTCC)Persian Type Culture Collection (PTCC)Bioprocess Engineering Projects:Bioprocess Engineering Projects:
–– BiopesticidesBiopesticides ProductionProduction–– Feed Production from Agricultural wasteFeed Production from Agricultural waste–– SCP ProductionSCP Production–– Production of Production of BiofertilizersBiofertilizers