bipn 148 lecture 10. biochemical basis of ltp modulation of nmda receptors
Post on 20-Dec-2015
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![Page 1: BIPN 148 Lecture 10. Biochemical Basis of LTP Modulation of NMDA receptors](https://reader033.vdocument.in/reader033/viewer/2022051619/56649d4e5503460f94a2da56/html5/thumbnails/1.jpg)
BIPN 148Lecture 10
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Biochemical Basis of LTP
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Modulation of NMDA receptors
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Calcium signaling and LTP/LTD
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Calcium activation of CaM kinases
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T TT
Catalytic Autoinhibitory Self-association
InhibitoryCalmodulin
Binding
286Autonomous
Activity
305/306Inhibitory
A
B C
P P
Structure of CaMKII
Verdaguer et al. (1999) Embo. J. 18:6329-6338.
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Calcium activation of CaMKII
![Page 8: BIPN 148 Lecture 10. Biochemical Basis of LTP Modulation of NMDA receptors](https://reader033.vdocument.in/reader033/viewer/2022051619/56649d4e5503460f94a2da56/html5/thumbnails/8.jpg)
Calcium activation of CaMKII
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Persistent activation of CaMKII
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Temporal Integration of a Ca Signal by CaMKII
Dineley et al. (2001) J. Neurochem. 77:961-971.
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NMDAReceptor
CaMKII
Transient CaMKIIActivation
Thr 286Autophosphorylation(persistently active)
NMDAR Association(persistently active)
CaMKII
CaMKII
Ca++/CaM
Effects of Ca/CaM on CaMKII
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LTP in Thr286A mutant mice
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LTP in Thr286A mutant mice