BASF Plant Science

PUFA Innovation for Functional Foods

Market Requirements for Plant Biotech

BASF Plant Science

Situation

Vision

Way

Agenda

PUFA Relevance

Increasing PUFA Food Applications

A new PUFA Source: Plant Biotech Benefit

Meet Market Requirements

Partner Approach

BASF Plant Science

Fatty acidcontent

150 years ago todaytime

Saturated

n-6

n-3(EPA/DHA)

n-6 : n-3 ratio = 2 : 1 n-6 : n-3 ratio = 20 : 1

Fatty Acid intake significantly changed during the last 150 years.

BASF Plant Science

PUFA have positive health effects and are a recommended part of a healthy nutrition.

Cardio Vascular DiseaseCardio Vascular DiseasePrevention of ventricular arrhythmias and cardiac arrestAnti-thrombogenic effectsHypolipidaemic effectsAnti-hypertensive effectsRetardation of growth & stabilization of atherosclerotic plaquesReduction of platelet-derived growth factor

Prevention of ventricular arrhythmias and cardiac arrestAnti-thrombogenic effectsHypolipidaemic effectsAnti-hypertensive effectsRetardation of growth & stabilization of atherosclerotic plaquesReduction of platelet-derived growth factor

Brain HealthBrain HealthDHA/EPA brain levels are reduced in blood of depressive patientsHigh DHA consumption is associated with reduced Alzheimer disease riskBeneficial effects of DHA/EPA in depression and neurodegenerative diseases are on its way

DHA/EPA brain levels are reduced in blood of depressive patientsHigh DHA consumption is associated with reduced Alzheimer disease riskBeneficial effects of DHA/EPA in depression and neurodegenerative diseases are on its way

n3-PUFAs show beneficial effects on …

Sources: GISSI Prevenzione Investigators et al., Lancet 1999;354:447-455 and Circulation 2002;106:2747-2757; [Thies F, Garry JM, Yaqoob P, Rerkasem K, Williams J, Shearman CP, Gallagher PJ, Calder PC, Grimble RF. Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial. Lancet 2003;361:477-85]; [Thies F, Garry JM, Yaqoob P, Rerkasem K, Williams J, Shearman CP, Gallagher PJ, Calder PC, Grimble RF. Association of n-3polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial. Lancet 2003;361:477-85]; [Harris WS, von Schacky C. The Omega-3 Index: a new risk factor for death from coronary heart disease. Preventive Medicine 2004;39:212-220]; (Hirayama S, Hamazaki T, Terasawa. Effect of docosahexaenoic acid-containing food administration on symptoms of attention-deficit/hyperactivity disorder - a placebo-controlled double-blind study. Eur J Clin Nutr 2004;58:467-73.) ; etc.

BASF Plant Science

An increasing portfolio of PUFA enriched food products will result in increasing raw material demand.

Baby Food/FormulaMilupa ®Ireland

Dairy - SpreadsCarrefour ®France

Bakery - BreadGFA Brands ®USA

Bakery - CrackersK-Group ®USA

Source: gnpd Database, 2005

Skimmed Milk Puleva ®Spain

BASF Plant Science

What are best sources to serve the demand of qualitative and cost competitive PUFA sources?

Fish PlantFermentationFermentation

BASF Plant Science

Lower Production CostsLower Production Costs

PUFA rich vegetable oils will show significant advantages compared to other sources.

Efficient production technology

Low fixed costs & low running costs

No investment for scale up

Efficient production technology

Low fixed costs & low running costs

No investment for scale up

Clear Quality AdvantagesClear Quality Advantages

Plant based PUFAHealthier overall fatty acid profile

Less environmental contamination

Better sensory properties

Healthier overall fatty acid profile

Less environmental contamination

Better sensory properties

BASF Plant Science

What are the requirements for plant based PUFAs?

Production cost advantagesPrice

British Nutritional task force, Scientific EU Committee for Food, etc.

Dosage

Plant based sourcingSustainability

Apply with existing production processProcesses

HACCP, Codex Alimentarius, EU directives, etc.

Legislation

No off-taste or smellStable during the shelf life

Taste

Quality requirements of the industryQuality

Plant based PUFA

BASF Plant Science

Let us know your requirements in future PUFA plant oils!

PUFA enrichedProducts

PUFA enrichedProducts

Research anddevelopment

Research anddevelopment CultivationCultivationField trialField trial

BASF Plant Science