brain circuits involved in emotion processing: subcortical regions bios e 232 sabina berretta, md
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Brain Circuits Involved in Emotion processing: Subcortical Regions BIOS E 232 Sabina Berretta, MD. Harvard Medical School McLean Hospital. Plan for today’s class. - PowerPoint PPT PresentationTRANSCRIPT
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Brain Circuits Involved inEmotion processing:Subcortical Regions
BIOS E 232
Sabina Berretta, MD
Harvard Medical School McLean Hospital
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Plan for today’s class
• Journal club presentations and discussion:
Carlin Aloe:Adolphs R, 2010. What does the amygdala contribute to social cognition? Ann N Y Acad Sci 1191, 42-61.
Kameron Sheikh:Berridge KC, Ho CY, Richard JM, DiFeliceantonio AG, 2010. The tempted brain eats: pleasure and desire circuits in obesity and eating disorders. Brain Res 1350, 43-64.
• Brain circuits involved in emotion processing: amygdala, limbic thalamus and cortical circuits
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Hypothalamus
Pituitary gland
Adrenal gland
MidbrainPons
Medulla
DA, 5HT, NE
motor response
Spinal cordBrainstem
glucocorticoidautonomic response
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The Human amygdala
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Orbital and medial prefrontal cortex (OMPFC)
Price, 2007
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The Human amygdala
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Amygdala circuitryModulation of motivated behavior in the context of emotionally/socially significant setting
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Intrinsic amygdalar connections
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The intercalated cell masses of the amygdala
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Amygdala control and modulation of visceral functions
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Modified from Price, 2003
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The amygdala receives inputs from all sensory modalities
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Note that all these connections, with the exception of that from the posterior thalamus are reciprocal. They provide sensory information to the amygdala and support amygdaloid modulation on sensory processing
Modified from Price, 2003
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The amygdala-forebrain circuit
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Within the forebrain, the amygdala is part of a circuit that includes the orbital and medial prefrontal cortex, medial thalamus, ventromedial striatum and ventral pallidum
Modified from Price, 2003
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Central n.Amygdala
Visceral inputs
Hormonal, autonomic, motor responses
Sensorythalamus
Sensory-related associative Cx areas:Gustatory and Visceral Insular Cx, temporal auditory and visual Cx, parietal and rhinal somatosensory Cx
Basolateralcomplex Orbitofrontal
cxMedial
prefrontal cxAnterior cingulate
gyrusLimbic
thalamus
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AmygdalaAttribution of emotional value
Fear/anxietySocial behavior
OPFCSocial behavior
Representation of reinforcer values
ACGAttention
MotivationResponse selection
DLPFCExecutive cognitive functions
Strategy generationWorking memory
ECxGating of cortical and subcortical
inputs to the HPMemory processing
HPContext-related cognitive
processingEpisodic memory
MDAttention
Decoding of stimulus/significance
relationship
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The amygdala organizes multiple aspects of emotional response:
• Immediate visceral response• Acquisition and response to emotional / arousing stimuli
• Modulation of memory consolidation in response to emotion
• Access to current motivational or affective value predicted by a specific stimulus• Emotional significance of social cues
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Cortico-amygdalo-cortical circuits and emotion-related learning
Berretta S., Stress, 2005
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18Hughlings Jackson
1835 - 1911
Jackson reported complex auditory and visual hallucinations, memory flashbacks and emotions in patients with temporal lobe epilepsia.The work of Penfield and collaborators (1955) confirmed these observations and reported that similar phenomena could be elicited in these patients by electrical stimulation of the lateral temporal cortex and from the amygdala (but not from other lobes in the brain).
Evidence for a complex role of the amygdala in emotion processing derives from temporal lobe epilepsy
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Sato et al 2004
The amygdala is activated by emotionally valenced stimuli and tracks their subjective relevance