Innova&ve  Technology  Company  focused  on…    

THE  HUMAN  BRAIN  

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Brain Dynamics, awarded at the Spin-Off'08 Call Awards from Malaga University (UMA), was founded by the Global CTO Director of Medical Software Multinational iSOFT (now CSC) and 7 Professor and Lecturer Doctors from UMA, providing a large amount of knowledge, high qualification and experience in neuroscience. The company has a Scientific and Technical Advisory Committee formed by the Founding and frontline professionals. And our staff has accumulated a significant amount of information and knowledge at different levels, not only on new programming techniques or BIG-DATA management, but also the use of ICT for creating diagnostic and therapeutic systems for patients with neurological or psychiatric diseases.

Introduction

Economics

Scien&fic(and(Technical((Commi1ee(

HUMAN ANATOMY

NEUROPHYSIOLOGY

NEUROLOGY

NEUROLOGY-LANGUAGE

COGNITIVE PSYCHOLOGY

PSYCHIATRY

PSICOPHARMACOLOGY

RADIOBIOLOGY

NEURO IMAGING

MEDICAL PHYSICS

GENOMICS & PROTEOMICS

COMPUTATIONAL INTELLIGENCE

R&D&I Coordination

Technical Director

Research Groups

DEVELOPMENT TEAM

KNOWLEDGE ENGINEER TEAM

RESEARCH GROUP 1

RESEARCH GROUP 2

RESEARCH GROUP 3

R&D&I TEAM

NEURO SURGERY

HUMAN RESOURCES

MARKETING & COMMUNICATION

FINANCES

NEURO REHABILITATION

SALES

Brain Dynamics has three main p r o d u c t s / s e r v i c e s l i n e s complemented each other. We process information on all kinds of neurological and p s y c h i a t r i c d i s e a s e s , transforming it into knowledge and managing it, using new technologies for creat ing products and services for professionals and Citizens.

Interconnec2on  Process  

Business Lines

A multidimensional knowledge database about healthy and pathological Human Brain that shows the direct and indirect relationships between different aspects of it (Anatomical Structures, Cognitive domains, Genes, Proteins, drugs, diseases, etc), extracted from scientific publications and other databases (Evidence-Based Neuroscience). BENEFITS

ü  Huge knowledge network. ü  Access from anywhere at anytime. Be Ubiquitous. ü  3D visualization of many information and their relationships. ü  Based on scalable Ontologies, and transferable to other areas

of interest. ü  Word processing based on natural language and fuzzy logic

techniques.

Knowledge Database

Thanks to the knowledge base that provides us NeuroSeek, we offer neuroimaging analysis services both for a single subject or for a given population (longitudinal/ transverse studies). We provide reports with objective data about the changes found and an interactive 3D visualization of the findings in white matter and/or grey matter.

Result: Better data for clinical professionals.

In the following pages, you will see some use cases…

Comparative data with other image processing systems

The best up-to-date algorithms for structure quantification have been developed and used. These algorithms significantly improve quality, accuracy and speed with respect to previous techniques.

Neuroimage Analysis

Voxel Metrics

Neuroimagen  

Some  of  these  parameters  are  considered  as  “structural  markers”,  which  are  being   iden&fied   as   of   great   importance   in   certain   diseases.   Thus,   it   is  necessary  to  have  the  most  accurate  techniques.    In  this  service,  116  gray  maDer  structures,  both  cor&cal  and  subcor&cal,  are  studied,   measuring   parameters   like:   thickness,   volume,   density   or   fractal  dimension   (almost   600   grey   maEer   parameters   are   computed   for   each  subject).   In   the   other   hand,   we   can   establish   whether   the   values   for   an  individual  falls  within  the  normal  range  or,  conversely,  represent  a  decrease  compared  to  the  healthy  popula&on,  in  which  case  it  could  be  an  indicator  of  some  pathology.  We  can  also  infer  the  func&onality  of  the  changed.    The   result   of   the   service   is   a   report  with   the  numerical   results   of   different  brain  regions,  with  emphasis  on  those  structures  that  have  greater  atrophy  in  rela&on  to  the  popula&on.  A  3D  visualiza&on  of  the  changes  found  is  also  available  to  the  user.  

MCI RISK

it  is  difficult  to  diagnose  demen&a  without   evidence   We   need   to  develop   tools   to   support  decision  making   that   could   help   the  specialist.    MCI  Risk  is  a  decision  making  tool  based  on  objec&ve  data  obtained  from   a   popula&on   study   focused  on   cases   with   CDR   =   0.5).   The  system,   from   a   MRI   study,   can  de tec t   s t ruc tu ra l   changes  consistent   with   mild   cogni&ve  impairment   (MCI),   and   to   classify  subjects   into   healthy   or   cogni&ve  impaired,   and   whose   accuracy  exceeds  90%.    The   result   is   a   report   expressing  the   findings,   their   rela&onship  with   the   popula&on   studied,   and  the  risk  (in  terms  of  probability)  of  mild  cogni&ve  impairment.  

(Fichas  de  Granada)  LoSE

LoSE,   Longitudinal   Studies   Evidence,   is   a   specific   processing   sequence   for  longitudinal  and  transversal  studies  useful  for:  

ü  To   quan&fy   structural   or   func&onal   changes   in   controlled   individuals  over  a  given  period  of  &me.  

ü  To  evaluate  therapy  effec&veness  objec&vely    Case  Study:    Longitudinal  study  to  evaluate  the  efficacy  of  donepezil  (DP)  versus  donepezil  combina&on   therapy   and   rehabilita&on   in   6   right   handed   pa&ents   with  chronic  aphasia  secondary  to  leX  perisylvian  stroke.    

Lesion Load

Given  a  mul&modal  MRI   study,   determine   those  areas  of   the   image   that  correspond  to  lesions  in  the  cerebral  white  maEer  (WM).  These  areas  are  classified  as  "mild  -­‐  moderate  lesion  load"  and  "extreme  lesion  load."  It  is  studied   in   overall   the   lesional   damage   at   136   white   maEer   regions,  established  by  the  use  of  standard  anatomical  atlas.    In   the   generated   report,   these   136  WM   regions   are   presented,   together  with  the  data  for  mild  -­‐  moderate  and  extreme  lesion  load,  volume  of  the  region  and  percentage  of  the  region  occupied  by  lesion  load.      Study   types:   From   a   series   of   studies   of   the   same   individual,   we   can  establish:  

Differences   between   baseline  MRI   and  MRI  performed   aXer   drug   treatment   showed   a  bilateral   increase   in  cor&cal   thickness   in   the  expected   cholinergic   regions:   orbitofrontal  cor&ces,   cingulate,   temporal/insular,   and  hippocampus,  amygdala,  cerebellum  and  leX  occipital  (red).            AXer   treatment   with   donepezil   and  rehabilita&on   objec&vely   showed   a   further  increase  of  cor&cal  thickness  in  all  the  above  structures,   especially   in   insula,   superior  parietal  cor&ces  and  sensory-­‐motor  leX  both  hippocampus   /   amygdala   and   putamen   of  both  hemispheres.    Conclusion:   The   DP   induces   structural  plas2city   in   innervated   by   the   cholinergic  system   structures.   The   changes   are   most  no2ceable   with   DP   /   Regia   in   the   leX  hemisphere.  

 ü  Volumetric  changes  in  each  of  the  

136  WM  regions.  

ü  Changes  in  the  level  of  lesion  load  for  each  region  considered.  

 This   type   of   longitudinal   study   is  especially   suited  and  designed   for   the  objec2fica2on   and   quan2fica2on   of  therapy  effec2veness.      In  addi2on,  popula2on   studies   can  be  conducted,   comparing   therapy   with  control  groups.  

Neuroimagen  

fMRI Analyzer

We  can  Offer:  ü  From   Experimental   Design   to   processing   of   brain   volumes   in  

Func&onal  Studies  

ü  Use  of  fMRI,  fMRIrs,  SPECT  or  PET  

ü  Establish  associa&ve  rules  between  func&on  and  anatomy  of  the  brain  that   enhance   classical   sta&s&cal   methods   when   extrac&ng  informa&on  from  the  data.  

ü  Informa&on   Visualiza&on:   We   can   represent   the   results   both   in   2D  (planar  or  spherical  mapping)  and  3D  as  showed  above.    

Coac2va2on  Matrix  

DTI Advisor

DTI  Studies  The  Diffusion  Tensor  Imaging  (DTI),  allows  us  to  determine  the  diffusion  of  water  molecules  in  the  brain,  indica&ng  paths  where  these  molecules  run  through.   Altera&ons   of   water   diffusion   in   certain   areas   of   the   brain   are  related  with  many  brain  diseases.    Our  advanced  algorithms  for  DTI  processing  can  obtain  several  parameters  for   each   voxel,   such   as   frac&onal   anisotropy   (FA),   apparent   diffusion  coefficient  (ADC),  etc.  

Tractography  Analysis  AXer  registering  the  anatomical  image  with  an  anatomical  atlas,  individual  results   may   be   compared   withother   published   studies.   Thus,   one   can  determine,  for  example,  the  physical  connec&vity  between  different  brain  regions.  Once  made  the   image  processing,  any  visualiza&on  type  (3D,  2D,  etc)  can  be  presented.  

Connectivity and Connectomics

ü  Structural   connec2vity   using   cor&cal  areas  and  DTI  (fiber  tracking)  

ü  Func2onal   Connec2vity   based   on   fMRI  in  res&ng  state  and  cor&cal  areas  

ü  Connectomic :   Determining   brain  networks  for  different  func&ons.  

Sistema  de  Neuronavegación  

ü Navigating through the patient's brain in 2D and 3D

ü Management and administration of the system through natural interfaces

ü  Preoperative estimation of the damages depending of surgical path and the future rehabilitation needs of the patient

ü Calculating the optimal surgical approach for the inference of minimal aftermath on the patient.

Our NeuVigator system has three layers: K n o w l e d g e , N e u r o i m a g i n g a n d Neuronavigation algorithms.

Neuviigator  is  in  the  process  of  approval  by  the  Spanish  Agency  for  Drugs  and  Health  Products  (AEMPS).  

Calcula&ng   the  op&mal   surgical   approach  for  the  inference  of  minimal  aXermath  on  the  pa&ent.  

NeuVigator

Selected  ROI  list.  Anatomical  parts  selected  for  visualiza&on.  

This  controls  the  transparency  of  the  image.  Select  showing    in  3D  or  orthogonal  format.  

Shows  affected  tracts,  path  between  brain  parts  and  address  them.  

Automa&c  connec&on  to  NeuroSeek  within  the  search  engine.  

The main services offered by our tool are:

ü  Navigat ing through the patient's brain in 2D and 3D.

ü  M a n a g e m e n t a n d administration of the system through natural interfaces

ü  F o r e c a s t p r e - s u r g i c a l rehabilitation needs of future cases that appear in the tool.

ü  Calculat ing the opt imal surgical approach for the i n f e r e n c e o f m i n i m a l aftermath on the patient.

ü  M u l t i m o d a l i m a g e s neuronavigat ion of real clinical cases.

Neutilus Our neuronavigation system for teaching purposes.

NEUtilus

Certifications and Platforms

Partnerships

Some Customers

Datos  de  Contacto  

BRAIN DYNAMICS Edif. de Bioinnovación. UMA C/Severo Ochoa, 34 Parque Tecnológico de Andalucía 29590 Campanillas Málaga (ESPAÑA)

Tel.: +34 951 136 978 Móvil: +34 653 937 331 info@brain-dynamics.es www.brain-dynamics.es

www.neuroblog.brain-dynamics.es

www.facebook.com/BrainDynamics @brain_dynamics www.youtube.com/BrainDynamicsTV

www.plus.google.com/u/0/+BrainDynamics/posts www.vimeo.com/braindynamics

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