ESO INSIDE TRACK CONFERENCE

Breast Cancer in Young Women Conference8-10 November 2012Dublin, Ireland

In collaboration with

In association with

Chairs: F. Cardoso, PT - B. Kaufman, IL A. Partridge, USHost-Chair: J. Geraghty, IEScientifi c Committee: S. Aebi, CH - H.A. Azim Jr, BE G. Freilich, UK - M.C. King, US F.A. Peccatori, IT

SECOND ANNOUNCEMENT

Breast cancer in young women is a devastating and complex disease. Breast cancer in women under 40 strikes when these women are at the peak of their reproductive years, family life and careers and still have many years ahead of them to suffer the long-term effects of treatment or the consequences of recurrent disease. The etiology of breast cancer in this population is poorly understood and most clinical trials focus on women who are over the age of 40, thus little evidence-based data is available about the optimal management of these patients. Further research is much needed in this field. This conference is an opportunity for the latest updates on this field and a platform for generating future research concepts and collaborations. It will cover epidemiology, molecular biology, genetics, pathology, surgery, radiotherapy, systemic therapy and fertility preservation in young women with breast cancer.

We hope that you will join us and contribute to further develop the understanding and treatment of this disease.

On behalf of the Chairs and Scientific Committee Members

Bella Kaufman

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FOREWORD

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LEARNING OBJECTIVES In depth learning of various aspects of breast cancer in young women Importance of multi-disciplinary management Management of difficult clinical cases

MAIN TOPICS Hereditary breast cancer Diagnostic tools in young women Local therapy Systemic therapy Pregnancy and breast cancer Fertility preservation Psychosocial aspects Management of side effects Case discussions

PARTICIPANT’S PROFILE Medical oncologists Surgeons Gynaecologists Radiation oncologists Onco-geneticists Pathologists Nurses Patient advocates

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O. Abulkhair, King Abdulaziz Medical City for National Guard, Riyadh, SAS. Aebi, Luzerner Kantonsspital, Lucerne, CHF. Amant, U.Z Gasthuisberg, Leuven, BEC. Anders, UNC Linenberger Comprehensive Cancer Center, Chapel Hill, USJ. Armstrong, St. Luke’s Institute of Cancer Research, Dublin, IEA.G. Arnold, Memorial Sloan-Kettering Cancer Center, New York, USH.A. Azim Jr., Jules Bordet Institute, Brussels, BEF.A. Calvo, Hospital General Universitario Gregorio Marañon, Madrid, ESF. Cardoso, Champalimaud Cancer Center, Lisbon, PTE. Cauzza, Ospedale Regionale Bellinzona e Valli, Bellinzona, CHA.M. Cluxton, Young Survival Coalition, Columbus, USR.E. Coleman, Weston Park Hospital, Sheffield, UKM. Colleoni, European Institute of Oncology, Milan, ITE. Connolly, St. James Hospital, Dublin, IEA. Costa, European School of Oncology, Milan, ITJ. Crown, NICB Dublin City University, Dublin, IES. Delaloge, Institut Gustave Roussy, Villejuif, FRJ. Dix, Adoption Consultant, Isle of Wight, UKG. Freilich, Europa Donna, London, UKE. Furlong, University College Dublin, Dublin, IEJ. Garber, Dana Farber Cancer Institute, Boston, USO.D. Gentilini, European Institute of Oncology, Milan, ITJ. Geraghty, St Vincent’s Hospital, Dublin, IEA. Graziottin, Saint Raffaele Resnati Hospital, Milan, ITA. Green, School of Medicine & Medical Science, Dublin, IEN. Harbeck, Breast Center, University of Munich, DEB. Kaufman, Sheba Medical Center, Tel Hashomer, ILM. Kell, University College Dublin, Dublin, IEC. Kelly, Mater Misericordiae Hospital, Dublin, IEJ. King, Royal Free Hampstead NHS Trust, London, UKM.C. King, University of Washington - School of Medicine, Seattle, USC.K. Kuhl, Aachen University Clinic, Aachen, DES. Loibl, German Breast Group, Neu-Isenburg, DEE.W. McDermott, St. Vincent Hospital, Dublin, IED. Meirow, Sheba Medical Center, Tel Aviv, ILE. Mocanu, Rotunda Maternity Hospital, Dublin, IEA. O’Doherty, National Cancer Screening Service, Dublin, IEG. O’Dowd, Irish Cancer Society, Dublin, IEO. Pagani, Oncology Institute of Southern Switzerland (IOSI), Bellinzona, CHS. Paluch-Shimon, Sheba Medical Center, Tel Hashomer, ILA.H. Partridge, Dana-Farber Cancer Institute, Boston, USF.A. Peccatori, European Institute of Oncology, Milan, ITI. Smith, Royal Marsden Hospital, Sutton Surrey-London, UKA. Tutt, Kings College London School of Medicine, Guy’s Hospital Camp, London, UK

FACULTY

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PROGRAMME

THURSDAY, 8 NOVEMBER

13:30 Christine Murphy Whyte memorial lecture Chair: J. Geraghty, IE

13:40 Presentation for a Young Irish Patient G. O’Dowd, IE

13:55 Presentation from the Young Survival Coalition A. Cluxton, US

14:10 Breast Cancer in Young Women: the magnitude of the problem B. Kaufman, IL

14:25 SESSION I: Debate: The biology of breast cancer in young women is unique 14:25 Introduction by Chair J. Garber, US

14:30 In favour M. Colleoni, IT

14:50 Against C. Anders, US

15:10 Coffee break

15:40 SESSION II: Familial and hereditary breast cancer Chair: A. Green, IE

15:40 Biology of BRCA - associated breast cancer A. Tutt, UK

16:00 Genetic counselling and testing A.G. Arnold, US

16:20 Cancer risk-reducing measures for high risk women J. Garber, US

16:45 The woman’s perspective G. Freilich, UK

17:00 Best Abstracs presentations Chairs: E. Connolly, IE and M. Kell, IE

17:30 Case discussion session 1 Moderators: B. Kaufman, IL Panel: Speakers and Chairs and S. Paluch-Shimon, IL

18:10-19:10 Satellite symposium

FRIDAY, 9 NOVEMBER

9:00 SESSION III: Staging of breast cancer in young women Chair: A. O’Doherty, IE 9:00 How to best use available techniques C.K. Kuhl, DE 9:20 Emerging technologies E. Cauzza, CH

9:40 SESSION IV: Loco-regional therapy. What should be different in young women Chairs: A. Costa, IT and J. Armstrong, IE 9:40 Surgery O.D. Gentilini, IT 10:00 Radiotherapy F.A. Calvo, ES

10:20 Coffee break

11:00 SESSION V: Adjuvant systemic therapy Chairs: N. Harbeck, DE and A.H. Partridge, US 11:00 Endocrine therapy for early breast cancer: standards and controversies O. Pagani, CH 11:25 Debate: All young early breast cancer patients should receive adjuvant chemotherapy 11:25 Introduction by Chair S. Aebi, CH 11:30 In favour F.A. Peccatori, IT 11:50 Against S. Delaloge, FR 12:10 Adjuvant bisphosphonates for young early breast cancer patients Chair: J. Crown, IE 12:10 Bisphosphonates in the adjuvant setting: ready for prime time? I. Smith, UK 12:35 RANKL signalling: bone metastasis and beyond R.E. Coleman, UK

13:00 Lunch and poster session

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14:30 SESSION VI: Advanced breast cancer Chair: S. Aebi, CH 14:30 Advanced breast cancer in young women: what should be different F. Cardoso, PT 14:55 Advances in targeted therapy N. Harbeck, DE

15:15 Case discussion session II Moderators: A.H. Partridge, US Panel: Speakers from and Chairs from sessions V and VI and O. Abulkhair, SA

16:00 Coffee break

16:30 SESSION VII: Fertility and adoption Chairs: E.W. McDermott, IE and E. Mocanu, IE 16:30 Fertility preservation D. Meirow, IL 16:55 Can I adopt a child? J. Dix, UK

17:10-18:40 Satellite symposium

SATURDAY, 10 NOVEMBER

8:30 SESSION VIII: Quality of life issues Chairs: A. Costa, IT and J. King, UK 8:30 Management of early menopause associated symptoms A. Partridge, US 8:55 The young couple and breast cancer A. Graziottin, IT 9:15 “Mommy has breast cancer”: how do the children cope? E. Furlong, IE

9:30 SESSION IX: Breast cancer and pregnancy Chair: F. Cardoso, PT and C. Kelly, IE 9:30 Breast cancer during pregnancy: the oncologist perspective S. Loibl, DE 9:50 Breast Cancer during pregnancy: the obstetrician/paediatric perspective F. Amant, BE 10:10 Pregnancy after breast cancer H.A. Azim Jr, BE 10:25 Pregnancy registry and trial project O. Pagani, CH

10:35 Coffee break

11:00 Case discussion session III Moderators: F.A. Peccatori, IT Panel: Speakers, Chairs and patient representative and C. Kelly, IE

11:40 SESSION X: Breast Cancer in Young Women Conference Statement Chairs: B. Kaufman, IL A.H. Partridge, US and F. Cardoso, PT

Panel: S. Aebi, CH - F. Amant, BE - H.A. Azim Jr, BE - F.A. Calvo, ES - E. Cauzza, CH S. Delaloge, FR - G. Freilich, UK - J. Garber, US - O.D. Gentilini, IT - N. Harbeck, DE

C.K. Kuhl, DE - S. Loibl, DE - D. Meirow, IL - O. Pagani, CH - F.A. Peccatori, IT

13:10 Closing remarks J. Geraghty, IE

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GENERAL INFORMATION

ORGANISING SECRETARIATFrancesca Marangoni - fmarangoni@eso.netTel: +39 02 85464525Roberta Ventura - rventura@eso.net Tel: +39 02 85464532

European School of OncologyVia del Bollo, 420123 Milan, ItalyFax: +39 02 85464545

OFFICIAL LANGUAGEThe official language will be English. No translation will be provided.

BADGEThe badge is the only official evidence of registration and should be worn at all times during the conference. Loss of badge means loss of registration.

INSURANCEThe organizers bear no responsibility for untoward events in relation to the participation in the Convention. Participants are advised to take out their own personal and travel insurancecoverage.

ABSTRACT BOOKAn abstract book will be published as supplement to The Breast and will contain abstracts of the invited lecturers and those submitted by the participants that have been accepted for oral or poster presentation or for publication only. The three best abstracts will be selected and proposed for oral presentation (Free registration will be granted to the first author of the three selected abstracts). Oral presentations will be scheduled on 8 November and poster session will be scheduled on 9 November.Online submission and information available on www.eso.net.

CME ACCREDITATION AND CERTIFICATESParticipants will be issued a certificate of attendance. Application for CME recognition will be submitted to ESMO for ESMO-MORA accreditation, to the Accreditation Council of Oncology in Europe (ACOE) and to the European Accreditation Council for Continuing Medical Education (EACCME), an institution of the European Union of Medical Specialists (UEMS). EACCME credits are recognized by the American Medical Association towards the Physician’s Recognition Award (PRA).Information on the status of the application can be obtained from the organizing secretariat.

NURSES AND PATIENT ADVOCATES Nurses and representatives of cancer patient advocacy non-profit organizations are eligible for a discounted registration fee: EUR 180 by 5 August, EUR 230 by 14 October, EUR 280 after 14 October and onsite.Interested nurses and patient advocates should contact Roberta Ventura (rventura@eso.net) in order to register to the conference.

VENUEO’Reilly HallUniversity College DublinBelfield, Dublin 4 - IrelandMap available here: www.ucd.ie/maps/UCD_Map_July_2011.pdf

GENERAL INFORMATION

TRAVEL GRANTSThanks to the generosity of BCY1 sponsors travel grants are made available on a competitive basis to: Physicians from middle- and low-income countries as defi ned by The World Bank; Physicians under the age of 40; Nurses; Patient Advocates.

Full applications should be submitted by 1 July to rventura@eso.net and include:

Curriculum vitae including full affi liation, contact details and date of birth; Letter describing motivation for attending; Physicians and nurses are furthermore asked to submit a letter of endorsement by the Institute/Department director or head nurse; The successful submission of an abstract (deadline 1 July) is not mandatory but would be considered in the selection process.

Travel grant recipients will receive a set amount to contribute to their travel and accommodation expenses, whilst registration will be processed directly by ESO free of charge. The following amounts will be refunded by bank transfer after the conference: EUR 500 for participants coming from Europe, Middle-East and North-Africa; EUR 1.000 for participants coming from other regions and overseas. The outcome of the application will be notifi ed by 27 July.

MEDIA REGISTRATIONThe congress is open to representatives of print and electronic media. Registration is free of charge to journalists who are in possession of a valid, recognised press card. Freelance journalists must present a commissioning letter on headed paper from a recognised news organisation or publication. Representatives of advertising, marketing and public relations companies are not eligible for free media registration. A copy of the Press Card or of the commissioning letter should be sent, together with the media registration form, to Roberta Ventura (rventura@eso.net).

CANCELLATION OF REGISTRATION OR REPLACEMENTCancellation should be notifi ed to ESO in writing. In case of cancellation without replacement, the fee less handling charges of EUR 100 will be refunded after the event, provided that the cancellation is received by ESO before 7 October. Replacements will be possible till 14 October 2012.

CONFIRMATION OF REGISTRATIONRegistration will be confi rmed by e-mail, by fax or by mail.

DEADLINESAbstracts: 1 July 2012

Travel grants: 1 July 2012Early registration: by 5 August 2012

Late registra tion: by 14 October 2012On-site registration: after 14 October 2012

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ACCOMMODATION FORM

BCY1 - BREAST CANCER IN YOUNG WOMEN CONFERENCE - 8-10 November 2012, Dublin, IrelandPlease fill in this form using BLOCK Capitals and send to Leah Perrot at MCI Dublin by email or fax to

esodublin@mci-group.com - Fax +353 1 2805405MCI Dublin - 1 Clarinda North, Dun Laoghaire, Co.Dublin, Ireland - Tel +353 1 2802641

For online accommodation booking and for more information on the hotels please go to www.eso.net

PARTICIPANT INFORMATION

Dr. Prof. Mr. Ms.

First name SurnameOrganisationAddressCity Postcode/ZipcodeState/County CountryTel Fax(including country code) (including country code)

BOOKINGAll rates are quoted in Euro, per night including breakfast and VAT.Please choose your hotel below

Single room Double room Twin roomStillorgan Park Hotel ( ) EUR 99 EUR 109 EUR 109Ballsbridge Inn ( ) EUR 75 EUR 90 EUR 90D4 Berkeley ( ) EUR 100 EUR 115 EUR 115

Check in dateCheck out dateSharing with

TERMS AND CONDITONSPlease see the online booking system on www.eso.net

CREDIT CARD DETAILSAccommodation payment and extras will be paid directly to the hotel. Please provide your credit card details in order to guarantee your booking. With out card details it will not be possible to make a booking.

CREDIT CARD: Mastercard or Visa onlyCredit card number / / / Expiry date /Card holders name (in Capital letters) CVV numberCard holders signature

I agree to the terms and conditions and that my credit card details will be forwarded to the appropriate hotel to guarantee my booking.

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If you require any assistance with your booking please do not hesitate to contact Leah Perrott at: esodublin@mci-group.com - Tel: +353 1 2802641

SECOND ANNOUNCEMENT

REGISTRATION FORM

BCY1 - BREAST CANCER IN YOUNG WOMEN CONFERENCE - 8-10 November 2012, Dublin, IrelandPlease fill in this form in BLOCK CAPITALS and send by the deadline to:

European School of Oncology - Roberta Ventura - Via del Bollo, 4 - 20123 Milan - ItalyTel: +39 02 8546 4532 - Fax: +39 02 8546 4545 - Email: rventura@eso.net

ONLINE REGISTRATION IS AVAILABLE AT www.eso.net

PARTICIPANT’S DETAILS

Dr. Prof. Surname NameInstitute Department StreetZip Code Town CountryPhone Fax MobileEmailDate of birth Birth place (town and country)ProfessionSpecialisation Main fieldVAT number (Compulsory for all freelancers) Fiscal Code (Italian residents only)

If your invoice details are different to those above, please complete the following section:Invoice contact detailsAddressPhone emailVAT number (Compulsory for all freelancers)

Fiscal Code (Italian residents only)

REGISTRATION FEES:Registration includes participation in all sessions, a copy of the Programme and the Abstract Book, coffee breaks and lunches as indicated in the programme.

Payable in Euro Early rate Late rate On site rate (by 5 August) (by 14 October) (after 14 October)Registration fee EUR 350 EUR 450 EUR 550BreastCentresNetwork Members EUR 250 EUR 450 EUR 550Club ESO Members EUR 250 EUR 450 EUR 550ESMO Members EUR 250 EUR 450 EUR 550

PAYMENT DETAILS:The registration is processed when payment accompanies the form (credit card details or copy of bank transfer)

Visa/Mastercard Card Number / / / Expire date / CV2 codeHolder’s name: and signature

BANK TRANSFER with no cost to the beneficiary (please provide a copy of the bank transfer):Banca Popolare di Milano, Agenzia 24 - Milan, ItalyEuropean School of OncologyNo. 16333IT96G0558401624 0000000 16333 - BIC: BPMIITM1024“BCY1” + your name

I authorize the European School of Oncology to use my personal data according to what is specified in Article 13 DLGS 196,available at www.eso.net or on request at fax number +39 02 8546 4545.

Signature Date

Bank:Account holder:Number:IBAN:Reference