b.sc: biology / medical analysis / jor. m.sc.: medical microbiology / jor
DESCRIPTION
Prof. Mamdoh Harahsha. B.Sc: Biology / Medical Analysis / Jor. M.Sc.: Medical Microbiology / Jor. Ph.D.: Medical Virology & Serology / UK. GENERAL PROPERTIES AND CLASSIFICATIONS. INTRODUCTION. Small Dependent on living cells Genome Have receptor-binding protein. Virus. Bacterium. - PowerPoint PPT PresentationTRANSCRIPT
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B.Sc: Biology / Medical Analysis /
Jor. M.Sc.: Medical Microbiology / Jor. Ph.D.: Medical Virology & Serology /
UK
Prof. Mamdoh Harahsha
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INTRODUCTIONINTRODUCTION
• SmallSmall
• Dependent on living cellsDependent on living cells
• GenomeGenome
• Have receptor-binding proteinHave receptor-binding protein
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Comparing the size of a virus, a Comparing the size of a virus, a bacterium, and an animal cellbacterium, and an animal cell
0.25 m
Virus
Animalcell
Bacterium
Animal cell nucleus
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Size of virusesSize of viruses
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Basic components of virusesBasic components of viruses
Virion (Intact virus):Virion (Intact virus):
• Capsid (capsomeres)Capsid (capsomeres)
• Nucleic acidNucleic acid
Both Both Nucleocapsid Nucleocapsid
# Envelope# Envelope
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Influenza virusInfluenza virus
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Virus symmetry Virus symmetry (Nucleocapsid)(Nucleocapsid)
• IcosahedralIcosahedral
• HelicalHelical
• ComplexComplex
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Capsid and CapsomeresCapsid and Capsomeres
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Helical Helical
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IcosahedralIcosahedral
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ComplexComplex
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Electron MicroscopyElectron Microscopy
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Virus Virus genomesgenomes
• # All DNA viruses ds # All DNA viruses ds EXCEPTEXCEPT
ParvoviridaeParvoviridae
• # All RNA viruses ss # All RNA viruses ss EXCEPTEXCEPT
ReoviridaeReoviridae
• # Positive & Negative stranded RNA# Positive & Negative stranded RNA
• # Exons & introns# Exons & introns
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Virus genome & transcriptional Virus genome & transcriptional mapsmapsDNA virusesDNA viruses
• Herpes & PoxvirusHerpes & Poxvirus
150 genes 150 genes No splicing No splicing
(Large No. of genes)(Large No. of genes)
• AdenovirusAdenovirus
30 genes 30 genes Viral Viral splicing splicing
• ParvovirusParvovirus
Few genes Few genes Viral Viral splicingsplicing
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RNA virusesRNA viruses
• Poliovirus: Poliovirus: +ve ssRNA+ve ssRNA
• Rabies: Rabies: -ve ssRNA-ve ssRNA
• Coronavirus: Coronavirus: +ve ssRNA+ve ssRNA
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Classification of VirusesClassification of Viruses
• NA: NA: DNA OR RNADNA OR RNA• Number of strands of NA: Number of strands of NA: ds ds
or ss, or ss, • Forms: Linear, Circular, Forms: Linear, Circular,
Continuous (or circular with Continuous (or circular with breaks as in HBV), or Segmentedbreaks as in HBV), or Segmented
• PolarityPolarity• Symmetry of NASymmetry of NA• EnvelopeEnvelope
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Nomenclature of virusesNomenclature of viruses
• Family:Family: --- viridae --- viridae
((AdenoviridiaeAdenoviridiae))
• SubfamilySubfamily --- Virinae--- Virinae
((AdenovirinaeAdenovirinae))
• Genera: Genera: --- virus--- virus(Adenovirus)(Adenovirus)
• Serotype: Serotype: --- Nnumber or letter--- Nnumber or letter
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DNA VIRUSESDNA VIRUSES
• Poxvirus:Poxvirus: (Pox : pock or pustule)(Pox : pock or pustule)
• Herpesvirus:Herpesvirus: (Herpes : creeping)(Herpes : creeping)
• Adenovirus:Adenovirus: (Adeno : gland)(Adeno : gland)
• Hepadnavirus: Hepadnavirus: (Hepa : liver, dna: DNA)(Hepa : liver, dna: DNA)
• Papovavirus:Papovavirus: (Pa: papilloma, (Pa: papilloma,
Po: polyoma, Va: vacuolating Po: polyoma, Va: vacuolating agent)agent)
• Parvovirus: Parvovirus: (Parvus: small)(Parvus: small)
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RNA VIRUSESRNA VIRUSES• Orthomyxovirus, paramyxovirusOrthomyxovirus, paramyxovirus
(Myxo: mucus)(Myxo: mucus)
• Rhabdovirus: Rhabdovirus: (Rhabdos: rod)(Rhabdos: rod)
• Picornavirus:Picornavirus: (Pico: small, (Pico: small, rna:rna:
RNA)RNA)
• Togavirus: Togavirus: (Toga: cloak)(Toga: cloak)
• Flavivirus: Flavivirus: (Flavi: yellow)(Flavi: yellow)
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• Reovirus: Reovirus: (R: respiratory, E: (R: respiratory, E:
enteric, O: orphan)enteric, O: orphan)
• Arenavirus: Arenavirus: (Arena: sand)(Arena: sand)
• Retrovirus: Retrovirus: (Re: reverse, (Re: reverse, TR: TR: transcriptase)transcriptase)
• Calicivirus: Calicivirus: (Calix: cup)(Calix: cup)
• Coronavirus: Coronavirus: (Corona: Crown)(Corona: Crown)
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Morphology of VirusesMorphology of Viruses
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Family name Genome Positive or negative stranded genome
Infectivity of isolated nucleic acid
Polymerase or transcriptase present in virion
Approx. genome size
DNA viruses
Parvoviridae ss +- + None 5
Papovairidae ds +- + None 8
Adenoviridae ds +- + None 36
Herpesviridae ds +- + None 150
Poxviridae ds +- - DNA-RNA 150
Hepadnaviridae ds +- ? DNA-RNA 3
RNA viruses
Astroviridae ss + + None v8
Picornaviridae ss + + None 8
Flaviviridae ss + + None 10
Togaviridae ss + + None 12
Coronaviridae ss + + None 30
Bunyaviridae ss - - RNA-RNA 16
Orthomyxoviridae ss - - RNA-RNA 13
Paramyxoviridae ss - - RNA-RNA 15
Rhabdoviridae ss - - RNA-RNA 15
Arenaviridae ss - - RNA-RNA 12
Retroviridae ss + - RNA-DNA 10
Reoviridae ds - - RNA-RNA 20
Filoviridae ss - - RNA-RNA 12
Caliciviridae ss + ? None 8
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Family name Representative viruses Approximate diameter of virion (nm)
Symmetry of of nucleocapsid
DNA viruses
Parvoviridae Human parvovirus 20 I
Papovaviridae Wart viruses 50 I
Adenoviridae Adenoviruses 80 I
Herpesviridae Herpes simplex viruses 180 I
Poxviridae Vaccinia virus 250 C
Hepadnaviridae Hepatitis B virus 40 I
RNA viruses
Astroviridae 30 I
Picornaviridae Polioviruses 25 I
Flaviviridae Yellow fever virus 30 I
Togaviridae Rubella virus 80 I
Coronaviridae Infectious bronchitis virus 100 H
Bunyaviridae California encephalitis virus 100 H
Orthomyxoviridae Influenza viruses 100 H
Paramyxoviridae Measles virus 150 H
Rhabdoviridae Rabies virus 150 H
Arenaviridae Lassa fever virus 100 H
Retroviridae HIV-1 100 I
Reoviridae Rotaviruses 70 I
Filoviridae Marburg virus Variable H
Caliciviridae Calicivirus 35 I
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