buccal bioadhesive drug delivery system g1ppt
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Buccal bioadhesive delivery system _ advancements....pptTRANSCRIPT
BUCCAL DRUG DELIVERY SYSTEMS
Under the guidance ofDr.B.Vasudha
M.pharm,Ph.D Professor Department of pharmaceutics
Presented byP.Jeevan reddy
M.Pharm 1styearPharmaceutics
Roll no :12H61S0320
CONTENTS• Introduction• Buccal drug delivary• Physiology of buccal environment• Types• Bio adhesion • Mechanism• Buccal drug delivery systems• Evaluation• Conclusion• References
INTRODUCTION
Adhesion : is the bond produced by interaction between an adhesive and a surface. Bioadhesion : is the state of bond formation in which either adhesive or surface is of biological origin. Mucoadhesion : is the interaction of the mucin layer with a polymer.
Buccal Drug Delivery
The buccal mucosa lines the inner cheek, and buccal formulations are placed in the mouth between the upper gingivae (gums) and cheek to treat local and systemic conditions.
The buccal route provides one of the potential route for typically large, hydrophilic and unstable proteins, oligonucleotides and polysaccharides, as well as conventional small drug molecules.
The oral cavity has been used as a site for local and systemic drug delivery.
Structure Of Oral Mucosa
Anatomy of oral mucosaStructure of oral mucosa
1) Epithelium
- stratum distendum
- stratum filamentosum
- stratum suprabasale
- stratum basale
2) Basal lamina
3) Connective tissue
- lamina propria
- submucosa
ADVANTAGES
LIMITATIONS
Drugs with large dose are difficult to be administered Eating and drinking may be restricted Possibility of the patient to swallow the tablet This route cannot administer drugs,which are unstable at buccal pH. This route cannot administer drugs,which irritate,bitter or unpleasant taste Small surface area is available for absorption
Buccal drug delivery and mucoadhesivity: :
The term ‘mucoadhesive’ is commonly used for materials that bind to the mucin layer of a biological membrane. Mucoadhesive polymers have been utilized in many different dosage forms in efforts to achieve systemic delivery of drugs through the different mucosae. These dosage forms include Tablets, patches, tapes, films, semisolids and powders
Mechanisms of bioadhesion
Wetting theory
Diffusion theory
Electronic theory
Adsorption theory
Fracture theory
FORMULATION OF BDDS
The basic components of buccal drug delivery systemDrug substanceBioadhesive polymersBacking membranePermeation enhancers
Bioadhesive polymers
IDEAL CHARACTERISTICS: Non toxic, non irritable, free from leachable impurities. Polymer pH should be biocompatible. Quick adherence, and suffice mechanical strength. Bioadhesive in both dry and liquid state. Acceptable shelf life. Optimum molecular weight.
TYPES: 1 st generation polymers : PAA, NaCMC , HPMC, Carbapol , Chitosan , Xanthan gum, PVA etc. 2 nd generation polymers : Lectins , Multifunctional polymers, Thiolated polymers etc.
Backing membrane
Backing membrane plays a major role in the attachment of bioadhesive devices to the mucus membrane. The materials used as backing membrane should be inert, and impermeable to the drug and penetration enhancer. Such impermeable membrane on buccalbioadhesive patches prevents the drug loss and offers better patient compliance. The commonly used materials in backing membrane include carbopol, magnesium Stearate, HPMC, HPC, CMC, polycarbophil etc
Permeation enhancers
Substances that help to promote drug permeation through the buccal epithelium are referred to as penetration enhancers, permeation promoters or absorption enhancers. Most of the compounds used as buccal mucosal penetration enhancers are the ones generally used to compromise barrier function.sodium lauryl sulfate, sodiumlaurateBile salts: Sodium glycodeoxycholate, sodium glycocholate, sodium taurodeoxycholate, sodium taurocholate
Types of buccal formulation
1) Buccal Tablets2) Buccal Patches and Films3) Buccal Semisolids (ointments and gels)4) Buccal Powders
Evaluation of buccal tablets
In vitro Swelling rate and bioadhesion studiesSurface pH studies Drug release studies Permeation studiesMucoadhesion strength Residence time
In vivo Drug release studiesStability studies in human saliva
Ex vivo Mucoadhesion timeMucoadhesion force Transmucosal permeation studied.
Possible designs of buccal drug delivery systems
Drugs given as buccal tablets• Propranalol• Metoprolol• Metoclopromide• Insulin• Nitroglycerine• Codeine• Morphine• Diltiazem• Chlorpheniramine maleate
Types of Buccal Dosage forms
Matrix type :
Drug, Adhesive, Additives are mixed together. Bidirectional patches. i.e. release drug both in Mucosa, and Mouth.
Reservoir type : Contains a cavity for drug, and additives separate from drug adhesive. Has an impermeable backing. For regulating direction of drug flow. Also prevents patch deformation, disintegration in mouth. Prevents drug loss.
Patch designs
Commercially available bioadhesive buccal delivery systems
• Buccal mucosal delivery of Proclorperazine: Buccastem
• Buccal mucosal delivery of nicotine: Nicorette
Reported buccoadhesive drug delivery system
Drug Dosage Action polymer Benzydamine Patch Local Pectin, PAA
Benzocaine Bioadhesive gel Local HPMC
Carvedilol Buccal patch Systemic HPMC
Clotrimazole liposome gel Local Carbopol
Captopril Tablet Systemic Carbopol, chitosan Clotrimazole Disk local Carbopol, HPMC Diltiazem HCL
ConclusionThe buccal mucosa offers several advantages over controlled drug delivery for extended periods of time. First pass metabolism in the liver and presystemic elimination in the gastrointestinal tract are avoided. With the right dosage form design and formulation, the permeability and the local environment of the mucosa can be controlled and manipulated in order to accommodate drug permeation.Buccal drug delivery is a promising area for continued research with the aim of systemic delivery of orally inefficient drugs as well as a feasible and attractive alternative for non-invasive delivery of potent peptide and protein drug molecules. However, the need for safe and effective buccal permeation absorption enhancers is a crucial component for a prospective future in the area of buccal drug delivery
References Edith mathiowitz. Encyclopedia of controlled drug delivery.In: mucosal
drug delivery, buccal.A wiley-interscience publication.P.555-557Yie W.Chien.Novel drug delivery systems.In: buccal drug delivery.2nd
ed.CBS publishers & distributors.New Delhi.P.210-215 S.P Vyas,Roop K.Khar.controlled drug delivery,concepts and
advances.vallabh prakashan.P.291-299 Anay R.patel,Dhagash v. patel,sharad v. choudry.Mucoadhesive drug
delivery system,International journal of pharmacy and life sciences.2(6).2011.848-856
• Kumar V, Aggarwal G,Zakir F,Choudry A.Buccal bioadhesive drug delivery-A novel technique.International journal of pharmacy and biological sciences.1(3).2011.89-102