building the virtual physiological human - cellml · liver (i.e. in the space of disse)’; thank...

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Building the Virtual Physiological Human Bernard de Bono [email protected]

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Page 1: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce

Building the Virtual Physiological Human

Bernard de [email protected]

Page 2: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
Page 3: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
Page 4: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
Page 5: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
Page 6: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
Page 7: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
Page 8: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
Page 9: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
Page 10: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
Page 11: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
Page 12: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
Page 13: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
Page 14: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
Page 15: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
Page 16: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
Page 17: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
Page 18: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
Page 19: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
Page 20: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
Page 21: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
Page 22: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
Page 23: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
Page 24: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
Page 25: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
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Page 27: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
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Page 29: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce

a. rate of urinary urea excretionb. rate of O2 delivery to muscle tissuesc. rate of change of plasma proteind. left atrial ANP secretione. total ADH secretionf. afferent arteriolar resistanceg. vascular resistance through muscle tissuesh. alveolar ventilationi. diuretic effect on tubular reabsorptionj. arterial O2 content

Page 30: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
Page 31: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce

a. rate of urinary urea excretionb. rate of O2 delivery to muscle tissuesc. rate of change of plasma proteind. left atrial ANP secretione. total ADH secretionf. afferent arteriolar resistanceg. vascular resistance through muscle tissuesh. alveolar ventilationi. diuretic effect on tubular reabsorptionj. arterial O2 content

Page 32: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce

a. rate of urinary urea excretionb. rate of O2 delivery to muscle tissuesc. rate of change of plasma proteind. left atrial ANP secretione. total ADH secretionf. afferent arteriolar resistanceg. vascular resistance through muscle tissuesh. alveolar ventilationi. diuretic effect on tubular reabsorptionj. arterial O2 content

Page 33: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
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COMPLEX

Page 35: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
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MOLECULE

Page 38: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
Page 39: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce

DBID:#3

DBID:#5

Page 40: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
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Page 46: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce

Two scenarios:

(i) the ‘level of oxygen in erythrocytes in the coronary blood’;

(ii) ‘the basement extracellular matrix that links sinusoidal endothelium with hepatocytes in the liver (i.e. in the space of Disse)’;

Page 47: Building the Virtual Physiological Human - CellML · liver (i.e. in the space of Disse)’; Thank You. Bernard de Bono. bdb@ebi.ac.uk. Virtual Physiological rotwork of excelle-lce
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Thank You

Bernard de [email protected]