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DEVELOPMENT OF SUSTAINED RELEASE BUPRENORPHINE FOR USE AS AN IMPROVED ANALGESIC IN TOXICOLOGY STUDIES: ASSESSMENT OF FORMULATION PHARMACOKINETICS Abstract 502 Poster 320 Koetzner, Lee 1 ; Stokes, William 2 ; Lance, William 3 ; Wnorowski, Gary 1 ; South, Natalie 4 ; Boulet, Jamie 1 1. Product Safety Labs, Dayton, NJ, US; 2. Kelly Services on behalf of NIEHS, Research Triangle Park, NC, US; 3. Wildlife Pharmaceuticals, Fort Collins, CO, US; 4. Battelle, Columbus, OH, US Background and literature Conclusions Results 2: Observations Materials and methods Product Safety Labs 12 24 36 48 60 72 84 96 0.0 0.5 1.0 1.5 Baseline Buprenorphine HCl (IR) 0.015 mg/kg NMP-SR buprenorphine 0.1 mg/kg Buprenorphine SR TM -Lab 0.1 mg/kg Time (vs. dose, hours) C e n i h p r o n e r p u B p ) L m / g n ( Results 1: Pharmacokinetics Results 3: Body weight and food consumption

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Scientific poster showing efficacy of a sustained release buprenorphine injection in rabbits for pain control.

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  • DEVELOPMENT OF SUSTAINED RELEASE BUPRENORPHINE FOR USE AS AN IMPROVEDANALGESIC IN TOXICOLOGY STUDIES: ASSESSMENT OF FORMULATION PHARMACOKINETICS

    Abstract 502Poster 320

    Koetzner, Lee1; Stokes, William2; Lance, William3; Wnorowski, Gary1; South, Natalie4; Boulet, Jamie11. Product Safety Labs, Dayton, NJ, US; 2. Kelly Services on behalf of NIEHS, Research Triangle Park, NC, US; 3. Wildlife Pharmaceuticals, Fort Collins, CO, US; 4. Battelle, Columbus, OH, US

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    Background and literature

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    Results 2: Observations

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    Materials and methods

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    Baseline

    Buprenorphine HCl (IR) 0.015 mg/kg

    NMP-SR buprenorphine 0.1 mg/kg

    Buprenorphine SRTM

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    Time (vs. dose, hours)

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    Results 1: Pharmacokinetics

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