TRICHURIASISBy Ryan Johnson

General Overview

NTD

>20% of human population infected

Locally underestimated

Public health crucial

Trichuris Nematodes Coevolved with Man

Infects old and new world monkeys

Discovered in 1740

Morphology

Fecal-Oral Transmission

Soil to mouth

Embryonic Development Must Occur Outside of the Human

3 weeks later

I won’t be able to hatch in your stomach if you eat me now. Gimme 3 weeks!

Time’s up… …EAT ME!!!

Signs and Symptoms Light infestation – asymptomatic Severe infestation – GI problems

Treatment

Mebendazole

Prevents Microtubule Polymerization

Preventive Chemotherapy

Heaviest burden on kids

Treatment 2x a year

1 dose = fraction USD

http://en.wikipedia.org/wiki/Trichuriasis Fernando, Ranjan L; Tropical infectious diseases :

epidemiology, investigation, diagnosis and management; London : Greenwich Medical Media, 2004.

http://www.who.int/intestinal_worms/en/index.html Hutchinson, et al; Clinical Trial of Mebendazole, A

Broad-spectrum Anthelminthic; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1681918/pdf/brmedj01446-0019.pdf/?tool=pmcentrez

Miller, et al; Mebendazole, An Effective Anthelmintic for Trichuriasis and Enterobiasis; http://jama.ama-assn.org/cgi/reprint/230/10/1412.pdf