INGREDIENTS:

Phenibut (4-amino-3-phenylbutyric acid)

clinically since the 1960’s for anxiety, sleep disorders, post-traumatic stress disorders, stuttering and the treatment of other neuroses. The addition of the phenyl ring to GABA allows the compound to more easily cross the blood-brain

agonist at GABA (B) receptors, although it does have some

established role of GABA (B) receptors is inhibition of the release of some neurotransmitters, and it may also serve as a negative feedback mechanism for GABA release (3).Phenibut also increases dopamine levels, and has been postulated that the structural similarity to beta-

that include neuroprotection by increasing resistance to the

production in the brain (5). Phenibut also protects dopaminergic neurons, and improved the condition of patients being treated with anti-parkinsonic drugs (6).

L-TaurineTaurine is a conditionally essential amino sulfonic acid present

cannot maintain adequate levels of taurine and supplementa-

These statements have not been evaluated by the Food and Drug Administration.This product is not intended to diagnose, treat, cure or prevent any disease.

Tranquility™ FormulaLife in the 21st century is stressful. We are constantly dealing with situations that result in stress, anxiety and a general feeling of unsettledness. Fear and anxiety go hand in hand. Disabling physical, emotional and mental symptoms

rate of prescriptions written for anti-anxiety drugs has more than doubled inthe past decade. Anti-anxiety medications, anti-depressants and tranquilizers account for one fourth of all prescriptions written in the U.S. each year.Tranquility™ formula contains key ingredients that restores and optimizesneurotransmitter function. Phenibut (4-amino-3-phenylbutyric acid) is aderivative of the neurotransmitter GABA and crosses the blood-brain barrier. Taurine acts as an inhibitory neurotransmitter and closely resembles the structure and metabolism of the other inhibitory neurotransmitters, GABA and glycine. Correcting the cause of the problem, neurotransmitter dysfunction, helps restore the delicate brain chemistry balance. Additionally, we added B6, B12 and folinic acid to supply essential nutrients that help improve and stabilizeserotonin levels and neurotransmission.

TECHNICAL DATA SHEET

S u p p l e m e n t F a c t sServing size: 1 capsuleServings per container: 90Amount per serving

Percent Daily Values are based on a 2,000 calorie diet.* Daily Value not established.

Other ingredients: Vegetarian capsules

%DV

Folinic Acid (5-formyl tetrahydrofolate)

Phenibut (4-amino-3-phenylbutyric acid)L-Taurine (free form)

Vitamin B12 (as Methylcobalamin)

2 0.5100100264211

mgmg

mcg mcgmgmg

100%25%

3846%25%

Vitamin B6 (as Pyridoxal-5-Phosphate)Vitamin B6 (as Pyridoxine HCl)

**

INTRODUCING!

tion becomes necessary (7).Taurine is important in metabolism, especially in the brain. It is essential for newborns, as they cannot yet make it. Adults can produce taurine from cysteine with the additional help of pyridoxine (B6). Taurine functions in electrically active tissues such as the brain and heart and stabilizes cell membranes. Taurine is an inhibitory neurotransmitter, and its main use has been to help treat epilepsy and other excitable brain states (8). Neurotransmitter transport systems have a common structure of 12 presumed transmembrane helices and include carriers for GABA, noradrenaline/adrenaline, dopamine, serotonin, proline, glycine, betaine and taurine.

Vitamin B6 (Pyridoxine/ Pyridoxal-5-Phosphate)Pyridoxine is required for amino acid metabolism. In the body, pyridoxine is converted to coenzymes pyridoxal phosphate and pyridoxamine phosphate, in a wide variety of metabolic reactions. These reactions include transamination of amino acids, conversion of tryptophan to niacin, synthesis of GABA in the central nervous system, metabolism of serotonin, norepinephrine and dopamine, metabolism of polyunsaturated fatty acids and phospholipids, and the synthesis of the heme group of hemoglobin (9). We use both forms of B6 to insure absorption is achieved, as a number of people cannot convert pyridoxine into the biologically active form of pyridoxal-5-phosphate.

Vitamin B12 (Methylcobalamin)Methylcobalamin is the biologically active form of B12. Vitamin B12 is a naturally occurring B complex vitamin that is formed by microorganisms. Research indicates that low levels of B12 contribute to poor mood and feelings related to anxiety and depression. Levels of neurotransmitters in the brain of B12

controls (10).

Folinic Acid (5-formyl tetrahydrofolate)Folinic acid also known as 5-formyl tetrahydofolate, is one active form in a group of vitamins known as folates. In the body folinic acid may be converted into any of the other active forms of folate. Folinic acid raises the tetrahydrobiopterin (BH4) levels, which is a critical cofactor for the manufacture of all mood-regulating neurotransmitters (11). Unlike regular folic acid supplements following an oral dose, up to 92% of folinic acid is absorbed from the gut. It remains in the body

Patients: Consult with your healthcare professional for the proper dosage and use of this formula.For more information about this and other ConditionSpecific Formulas® please visit our website at:

www.mpn8.com

Portland, OR 97225

REFERENCES:1. CNS Drug Rev. 2001 Winter;7(4):471-612. Pavlov J Biol Sci. 1986 Oct-Dec;21(4):129-403. Am J Physiol Gastrointest Liver Physiol. 2001Aug;281(2):G311-54. Pharmacol Toxicol. 1990 Jan;66(1) 41-45. Eksp Klin Farmakol.1994 Mar-Apr;57(2):13-66. Zh Nevropatol Psikhiatr Im S S Korsakova.1986;86(8):1146-87. Ann Med 1999;31:318-28. Adv Pediatr 1985;32:1-429. McKevoy GK, ed AHFS Drug information Bethesda,MD:199810. Int J Vitam Nutr Res. 1977;47(2):119-211. Godfrey PS Toone BK, Carney NW et al. Lancet 1990;336:392-39512. Folates: Supplemental Forms and Therapeutic Applications by Gregory S. Kelly ND

longer and the majority is converted to the active coenzyme.In this form, folinic acid can be directly uptaken by the blood-brain barrier that ordinarily remains impermeable to dietary

treating mental disorders (12).