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Presented by:

Ali Kareem Abdulameer Mukhtar

Vian MohemmedFuad JamalFrmesk Sahib

LARYNGEAL CANCER

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Anatomy Incidence Risk factors Symptoms Subtypes Staging Diagnosis Treatment

ANATOMY OF THE LARYNX

The larynx is an organ in the throat. It’s at the front of your neck.

It’s cartilages. *

It consists of three main parts.*

It has 2 groups of muscles Extrinsic & Intrinsic.

CANCER CELLS

What are the cancer??

Benign tumors Malignant growths

INCIDENCE Larynx CA. is the most common

head & neck cancer. Male: female = 4:1 >90% squamous cell cancer. Glottic CA most common in

Caucasian. Glottic CA = supraglottic in African

American.

RISK FACTORS

Tobacco smoking

Alcohol

HPV infection in the throat

The backward flow of liquid from the stomach to the throat.

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SYMPTOMS

1- Changes to voice.2- Swelling or lump in neck or throat

.3- Difficulty swallowing.4- Earache that doesn’t get better

5- Feeling breathless. .6- Cough that doesn’t go away

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SUBTYPES

1- Supraglottic cancer : 40%2- Glottic cancer : 59%3- Subglottic cancer: 1%

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STAGING

Early cancer: Stage 0, 1, or 2

Stage 0 Stage 1

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STAGINGAdvanced cancer: Stage 3 or 4

Stage 3

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DIAGNOSIS

History

Physical examination

Indirect laryngoscopy

Direct laryngoscopy

Biopsy

CT and MRI

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TREATMENT

Before Treatment

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TREATMENT

Methods:1. Radiotherapy2. Chemotherapy3. Targeted therapy4. Surgery

Choice of Treatment

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Radiotherapy

When is it used?

Side effects

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Chemotherapy

For patients of advanced stage laryngeal cancer

Side effects

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Targeted Therapy

Maybe given with radiotherapy

Much more specific than chemotherapy

Cetuximab: the first approved targeted therapy for Laryngeal cancer

SURGICAL OPTIONS

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Trans- oral laser microsurgery

Laryngectomy Partial laryngectomy Total laryngectomy

Surgery

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TOTAL LARYNGECTOMY

Indications: T3 or T4 unfit for partial

Extensive involvement of thyroid and cricoid cartilages

Invasion of neck soft tissues

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Total laryngectomy specimen

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Post total laryngectomy

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VOICE RESTORATION

Esophageal speech

Tracheo-esophageal puncture

Electrolarynx

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Esophageal speech

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Tracheo-esophageal puncture (TEP)

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Electrolarynx

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