Rapid detection for life protection

MDID LAB Molecular Diagnostics

BacteriaVirus

Fungus

Parasites

BotulismpneumoniaUrinarytractinfections

Tetanus

Gasgangrene

Endocarditis Dipheteria

Bronchitis

SalmonellaImpetigo

Cellulitis

Shigella

Listeriosis

Septicarthritis

Plague

Scarletfever

Puerperalfever

Syphilis

Osteomyelitis

Skin

MeningitisGastroenteritis Otitismedia

Malaria

Dengue

Measles

HIVHepatitis

Cholera

Sinusitis

Eyeinfections

Papillomavirus

Gonorrhoea

Brucellosis

QfeverSepsis

AfricanTrypanosomiasis

JapaneseEncephalitis

Leishmaniasis

StrepThroat

TuberculosisGastritis

Legionnaires

Disease

Typhoid

fever

Clostridiumdifficile

HumanInfections

HUS

Necrotizing

TSS

Tinea

Herpes

Chagasdisease

Chickenpox

CMV

Epsteinbarr

giardiasis

mononucleosis

ParvorirusPolio

Toxoplasmosis

Whoopingcough

mumps

Ascariasis

Tapeworm

Ebola

Rotavirus

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Human-InfectionsBacteriaVirusFungusParasitesClostridium-difficilePNEUMONIAUrinarytract-infections

Infectious Diseases

Infectious diseases kill more people worldwide than any other single cause

Pneumonia

3Milliondeaths/Year>40Pathogens

PATIENT

DOCTOR

LABORATORY

RESULTS

Time-consuming microbiological diagnosis

3 days – 1 month

Sample culture

Isolation and identification

Antimicrobial resistance

Wait for growth

“The diagnostic is essentially clinical. Serological testing normally takes 3 days while cultural exams, when possible, can take at least 2-6 days” (MªLuz Araújo, infecciologist)

Infectious Diseases – The problem

Infectious Diseases – The problem

“Most of the times we don’t know what we are actually treating for” (Carla Santos, infecciologist)

No pathogen directed

therapy applied

T Welte et al. Thorax 2012;67:71-79 Culture negative results

Infectious Diseases – The need

Faster microbiological results

Faster pathogen identification

Faster antimicrobial resistance detection

Higher sensitivity

Nuclei Acid Extraction (DNA/RNA)

RT-PCR Biological Sample

Blood Urine

Sputum Cerebrospinal fluid

Biopsy

Superior microbiological identification

specific primers and probes MDID Proprietary

Bacteria

Virus

Fungi

Parasites

Infectious Diseases – Our solution

Our solution– Direct benefits Conventional Diagnostics MDID Lab

Time

Sample amount

Specificity

Simultaneous antimicrobial resistance

Sensitivity

Pathogen detection

>98%

10 mL 0.5 mL

20%-80% >95%

3 DAYS – 1 MONTH 6-24H

Ó P

BACTERIA/FUNGI 1/test

bacteria/fungi/virus/ Parasites - up to 45/test

90%

MARKET

USA 1.1M Cases

Europe 1M Hospitalized Pneumonia cases

Global Molecular Diagnostic Market 2013 Valued at 4.5 B USD

Source:marketwatch

NUCLEIC ACID AMPLIFICATION TECHNOLOGY

COMPETITORS

Proof-of-concept

•  Patent submission •  Regulatory Issues •  Clinical validation

•  R&D •  Primer/probe

development

2016 2017 2018

Business development and

Regulatory

2009

Investment:1million

2019

ROADMAP

Development of new diagnostic panels

LicensetheuseforinternationaldiagnosticlaboratoriesExitstrategy

2020

1st Diagnostic Panel:

Pneumonia infections

TEAM

SandraAguiarPhDinMicrobiology

GeneralManagementProgram

PostdoctoralresearcherPostdoctoralresearcher

PhDinMolecularBiology

HospitalManagementSpecialization

CatarinaBaptista

Thank You

Contact: mdidlab@gmail.com

MDID Lab