can coatings primer and safety assessment: · pdf filepressco technology , inc. pressco...
TRANSCRIPT
![Page 1: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/1.jpg)
Can Coatings Primer and Safety Assessment: Communicating Evidence of Absence
![Page 2: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/2.jpg)
Conflict of Interest Statement
Mark Maier is currently a paid consultant and former employee of the Valspar Corporation. This educational presentation is made solely by and on behalf of Sheperian Toxicology, LLC who is responsible for its content. Mark Maier received no compensation from Valspar Corporation for this work.
Fair Use Notice Graphics in this presentation are/were publicly available and are used solely for educational purposes and may not be used otherwise. Source credit is given for graphics in this presentation when available.
![Page 3: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/3.jpg)
Different Cans, Different Coatings
![Page 4: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/4.jpg)
Food & Beverage Ends‒Coil Coating
National Coil Coating Assn
Valspar Corp.
![Page 5: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/5.jpg)
Food Can Manufacturing Two Piece
Side Seam Three Piece
![Page 6: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/6.jpg)
Beverage Can Multi-Step Engineering Marvel
“Engineer Guy” Bill Hammack, Univ. Illinois The Ingenious Design of the Aluminum Beverage Can
YouTube: https://www.youtube.com/watch?v=hUhisi2FBuw
![Page 7: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/7.jpg)
Demands Placed on Coatings
“Engineer Guy” Bill Hammack, Univ. Illinois The Ingenious Design of the Aluminum Beverage Can
![Page 8: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/8.jpg)
Beverage Can Manufacturing
Crown Beverage Packaging, Inc.
Visy Industries Holdings Pty Ltd
![Page 9: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/9.jpg)
Beverage Can Ends
Han, J. et al. Appl. Erg 2008. 39: 150
Pressco Technology , Inc.
Pressco Technology Inc.
End Punched
from Coated
Coil
Tooling and Riveting
Coating must maintain seal after tooling and riveting
![Page 10: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/10.jpg)
Migration from Film
INCDTIM Romania
![Page 11: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/11.jpg)
Migration Chromatogram
Innovations in Food Safety, Shelf Life and Food Safety
![Page 12: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/12.jpg)
If BPA is Replaced, What Choices are Available?
Acrylic Vinyl Oleo PE 1 PE II
Beverage End
Beverage Body 3PC Food Food D&I Food
DRD Food End Food EZO Closure
BPA BASED EPOXY
![Page 13: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/13.jpg)
Wish List for BPA Replacement Coating
1. Epoxy Performance–must be epoxy chemistry
2. No estrogenic monomers
3. Total Migration–< 50 ppm (0.5 mg/in2); < 1,000 Da.
4. Specific Migrations–< 0.5 ppb (TTC-based)
5. Industrial Scale Raw Materials
6. Acceptable cost
![Page 14: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/14.jpg)
Step 1 Find New Materials
Valspar Corp
Valspar Corp
![Page 15: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/15.jpg)
Most New Coatings were Made Using Pre-Authorized Materials Listed “in the Box”
![Page 16: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/16.jpg)
Epoxy Monomers in the Box were Estrogenic
New Molecules Were Needed
![Page 17: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/17.jpg)
Performance vs. Hazard
Chemical Reactivity
No Biological Hazard
![Page 18: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/18.jpg)
Molecules were Needed that React with Each Other
…but physiologically, do…
![Page 19: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/19.jpg)
…And
![Page 20: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/20.jpg)
What Can be Learned from BPA Epoxy?
C. 4,4'-methylenediphenol functionality found in BPA is essential
A. Bisphenol A is estrogenic in vitro 1
2
B. There are two sources of BPA in the polymer synthesis
![Page 21: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/21.jpg)
A. Is There a Non-Estrogenic Bisphenol?
Bisphenols are the only commercially viable source for 4,4'-methylenediphenol functionality.
![Page 22: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/22.jpg)
BPA
B. Could the Bisphenol be Taken Out of the Last Step?
![Page 23: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/23.jpg)
C. V70 Route of Synthesis
4,4'-methylenediphenol functionality
![Page 24: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/24.jpg)
Why Should People Believe these Molecules are Safe?
Just because I said so?
![Page 25: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/25.jpg)
Prescriptive Approaches were Tried
defa
ult
Force Fit
Green Screen TI
PED
co
ntra
dict
misunderstand
Excessive
![Page 26: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/26.jpg)
Keeping in Mind Reactants ≠ Products
≠
≠
![Page 27: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/27.jpg)
Sodium
Chlorine
GreenScreen®
![Page 28: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/28.jpg)
Designing endocrine disruption out of the next generation of chemicals. Schug et al. Green Chem., 2013,15, 181-198
“While in silico and in vitro assays offer less costly starting points, in vivo assays are necessary to conclude that a
chemical is unlikely to have EDC activity.” http://www.tipedinfo.com/tiped_tier/guiding-principles/
?
Tiered Protocol for Endocrine Disruption (TiPED)
![Page 29: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/29.jpg)
defa
ult
Force Fit
Green Screen
TIPE
D
cont
radi
ct
misunderstand
Excessive
![Page 30: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/30.jpg)
![Page 31: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/31.jpg)
Do Your Own Science First Table III. Summary of analysis and assay results for ER (read-across target) and read-across sources TMBPFDGE, BADGE, NOGE and oligo-BFDGE.
Green = Negative experimental result, Red = Positive experimental result RA = Read-across (only applies to “target” substance, ER) ND = no data available Numbers indicate relative potency in the standard Ames assay (Table IV)
ER TMBPFDGE BADGE NOGE oligo-
BFDGE In vitro
MLA -S9 culture ND MLA +S9 culture ND
TA-98 -S9 plate TA-100 -S9 plate
TA-1535 -S9 plate TA-1537 -S9 plate
TA-98 +S9 plate TA-100 +S9 plate 3.9 4.7 25.0
TA-1535 +S9 plate 33.6 35.5 117.8 TA-1537 +S9 plate
Mutagenicity CAESAR Model Model Model Model Model Model TA-98 -S9 mpf RA ND ND ND
TA-100 -S9 mpf RA ND ND ND TA-1535 -S9 mpf RA ND ND ND TA-1537 -S9 mpf RA ND ND ND
TA-98 +S9 mpf RA ND ND ND TA-100 +S9 mpf RA ND ND ND
TA-1535 +S9 mpf RA ND ND ND TA-1537 +S9 mpf RA ND ND ND
GS GADD45 -S9 culture RA ND ND ND GS GADD45 +S9 culture RA ND ND ND
In vivo
Micronucleus Oral Oral Oral ND Oral Comet Assay or other DNA damage Oral Oral Oral Oral Oral
Chromosomal aberration RA ND Oral Oral Oral
Transgenic Mouse RA ND ND Oral
Carcinogenicity RA ND ND Dermal
Carcinogenicity Model Model Model Model Model Carcinogenicity QSAR QSAR QSAR QSAR QSAR
Repeated Oral Dose (mg/kg-bw/d)
28-56Day NOAEL = 100 LOAEL = 300 Repro/Dev
NOAEL = 300
ND
Chronic NOAEL = 15
Subchronic NOAEL = 50; LOAEL = 250
ND
90-Day NOAEL = 250 (limit dose)
14-day NOAEL =
300; LOAEL = 1000
![Page 32: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/32.jpg)
32
(Listing does not necessarily imply endorsement, approval, or further discussion)
Dutch G4
Regulatory
Ask for Help
![Page 33: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/33.jpg)
Then… Let Your Best Critics Review Your Work, do Their Own, and Try to Prove You are Wrong.
![Page 34: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/34.jpg)
Go Beyond …
Female mammary glands (right side) were whole-mounted for three-dimensional inspection
Terminal end buds, branching, budding and ductal extension were examined; lymph node was used as point of reference
Qualitative analysis – Absence – Minimal – Slight – Moderate – Marked – Abundant
![Page 35: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/35.jpg)
Go Beyond …
Extract
Concentration
![Page 36: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/36.jpg)
![Page 37: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/37.jpg)
References
“Engineer Guy” Bill Hammack, Univ. Illinois. The Ingenious Design of the Aluminum Beverage Can. https://www.youtube.com/watch?v=hUhisi2FBuw
Soto AM, Schaeberle C, Maier MS, Sonnenschein C, Maffini MV. Evidence of
Absence: Estrogenicity Assessment of a New Food-Contact Coating and the Bisphenol Used in Its Synthesis. Environ Sci Technol. 2017 Feb 7; 51(3):1718-1726.
![Page 38: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/38.jpg)
Acknowledgements
Tom Mallen, Ronnie Weaver, and everyone at Valspar
Maricel Maffini–Independent Consultant Ana Soto Lab–Tufts University Food and Beverage Brand Owners Can Makers …and
![Page 39: Can Coatings Primer and Safety Assessment: · PDF filePressco Technology , Inc. Pressco Technology Inc. End Punched from Coated Coil . Tooling and Riveting . Coating must maintain](https://reader034.vdocument.in/reader034/viewer/2022051405/5a9ecbbc7f8b9a76178be1de/html5/thumbnails/39.jpg)
…Talented Scientists & Engineers from these Organizations (Listing does not necessarily imply endorsement or approval)
39
Dutch G4