Annual Report2007-2008

Canadian Council on Animal Care

Canadian Council on Animal Care 1510-130 Albert StreetOttawa, ON K1P 5G4

Tel: 613-238-4031Fax: 613-238-2837

Email: ccac@ccac.caWebsite: http://www.ccac.ca

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INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . .1

CCAC’S GRANT SUBMISSION TO CIHR AND NSERC FOR 2008-2011 . . . . . . . . . . . . . . . .1

HARRY C. ROWSELL AWARD FOR OUTSTANDING SERVICE TO THE CCAC . . . .1

REVIEW OF THE STRUCTURE AND OPERATIONS OF COUNCIL . . . . . . . . . . . . . . .2

RECOGNITION OF CCAC STANDARDS . . . .2

1. At the National Level . . . . . . . . . . . . . . .2

2. At the International Level . . . . . . . . . . . .4

3. Promoting the Principles of the Three Rs . . . . . . . . . . . . . . . . . . . . . . . . . . .5

RESULTS BY BUSINESS LINE . . . . . . . . . . . . . .6

1. Assessment . . . . . . . . . . . . . . . . . . . . . . . .6

1.1 Assessment Visits . . . . . . . . . . . . . . .61.2 Assessment and

Implementation Reports . . . . . . . . .61.3 Additional Assessment Sector

Activities . . . . . . . . . . . . . . . . . . . . . .6

2. Guidelines . . . . . . . . . . . . . . . . . . . . . . . . .7

2.1. Guidelines Development . . . . . . . .72.2 Additional Guidelines

Program Activities . . . . . . . . . . . . . .7

2.3 CCAC Fellowship . . . . . . . . . . . . . .8

3. Education, Training and Communications . . . . . . . . . . . . . . .9

3.1 Training and Education . . . . . . . . .93.2 Communications . . . . . . . . . . . . . . .9

4. Finance . . . . . . . . . . . . . . . . . . . . . . . . . . .10

APPENDIX ICCAC SURVEY OF ANIMAL USE – 2006 . . . . . . . . . . . . . . . . . . . . . . . . . . .11

APPENDIX IIMEMBERS ON CCAC ASSESSMENT PANELS . . . . . . . . . . . . . . . .12

APPENDIX IIICONTRIBUTORS TO THE GUIDELINES PROGRAM . . . . . . . . . . . . . .15

APPENDIX IVCCAC ORGANIZATIONAL CHART . . . .17

APPENDIX VMEMBERS OF THE CCAC STANDING COMMITTEES . . . . . . . . . . . .18

APPENDIX VICCAC MEMBER ORGANIZATIONS AND REPRESENTATIVES . . . . . . . . . . . . .20

APPENDIX VIICCAC SECRETARIAT CONTACTS . . . . . .21

TABLE OF CONTENTS

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The Canadian Council on Animal Care (CCAC) isan autonomous and independent body, created in1968 to oversee the use of animals in science inCanada. The CCAC is registered as a not-for-prof-it organization, and is financed primarily by theCanadian Institutes of Health Research (CIHR)and the Natural Sciences and EngineeringResearch Council (NSERC), with additional contri-butions from federal science based departmentsand private institutions participating in its pro-grams. It is governed by a Council of representa-tives from 24 national organizations.

The CCAC acts as a quasi-regulatory body and setsstandards on animal use in science that applyacross Canada. It is accountable to the general pub-lic and is responsible for the dissemination ofinformation on the use of animals in science toCanadians. The CCAC develops guidelines, poli-cies and comprehensive annual statistics on thenumber of animals used in science, and producesan annual report to disseminate information to itsconstituents and the general public. The presentreport covers activities undertaken by the CCACfrom April 1, 2007 to March 31, 2008.

INTRODUCTION

CCAC’s GRANT SUBMISSION TO CIHRAND NSERC FOR 2008-2011

The CCAC grant application, titled AchievingSustainable Good Animal Practice® in Science, wasdelivered to the granting Agencies on December14, 2007. The CCAC sought a 39% increase inbudget over the 2008-2011 term to: (i) consolidateprogress achieved over the past six years amidprevious chronic under funding; (ii) address theincreasing deficit of funding for services to aca-demic institutions; and (iii) meet the growingneeds of its academic clients in a sustainable man-ner. The operations of the CCAC were reviewed

by the CIHR/NSERC Evaluation Committee onMarch 10, 2008.

In a May 9, 2008 letter, the presidents of NSERC andthe CIHR confirmed a 37.3% increase in the 2008-2011 three-year grant of the CCAC. This unprece-dented success rate of 96% of the requested fundingis a clear indication of the granting Agencies and thescientific community’s strong support for theCCAC and the continuation of its activities.

HARRY C. ROWSELL AWARD FOR OUTSTANDING SERVICE TO THE CCAC

The Harry C. Rowsell Award for OutstandingService to the CCAC is the highest honourbestowed upon individuals who have made trulyoutstanding contributions to the CCAC and its pro-grams. In exceptional circumstances, more thanone award can be bestowed upon meritorious can-didates in a given year. Drs. Edwin Kroeger andPeter Flanagan were nominated for their joint sem-

inal contributions in leading the CCAC throughtimes of unprecedented difficulties in the late 1990stowards the present well-structured, nationally andinternationally recognized CCAC system. Thenomination of Drs. Kroeger and Flanagan receivedunanimous support from the Award SelectionCommittee, the CCAC Board of Directors andCCAC Council members.

REVIEW OF THE STRUCTURE ANDOPERATIONS OF COUNCIL

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1. At the National Level

In Canada, the use of animals in science is aprovincial responsibility, with the guidelines andpolicies set by the CCAC serving as national refer-ence standards. The provincial legislations in fiveof the six provinces that have legislated on thematter make specific references to the CCACguidelines and policies. The CCAC encouragesfederal and provincial regulators and funders ofanimal research to reference the CCAC standardsin their legislation and programs.

Canadian Veterinary Medical Association(CVMA)

The following agreement has been reached, effec-tive August 10, 2007: “That the CCAC acceptsCVMA accreditation as evidence of pedagogicalmerit of live animal use by the Animal HealthTechnician/Veterinary Technician (AHT/VT) col-leges; and that the CVMA recognizes the CCACCertificate of GAP – Good Animal Practice® as tan-gible evidence of a program’s commitment toappropriate animal care and use, and to high stan-dards of animal welfare.” Accordingly, the CVMAhas accepted the CCAC Certificate of GAP – GoodAnimal Practice® as a requirement for CVMAAHT/VT training program accreditation.

Experts Committee for Human ResearchParticipant Protection in Canada

A one-hour presentation on the CCAC structureand function was given by the Executive Directorto members of the Experts Committee for HumanResearch Participant Protection in Canada onOctober 23, 2006.

The draft report of the Experts Committee, MovingAhead, was published on August 15, 2007(www.hrppc-pphrc.ca). Under Section 2.5.7 of thereport, the Experts Committee concluded that theCCAC model has a number of advantages in thatit: promotes partnership with research organiza-tions and a community of practice in Canada; suc-cessfully promotes a culture of good animal prac-tice and care; provides effective leadership inCanada; provides national education workshopsand supports local educational activities; has beena driver in promoting behavioural changes amonginvestigators; facilitates development among poli-cy, education and certification processes whileminimizing conflicts of interest; has a broad stake-holder and volunteer base; has developed an effec-tive compliance mechanism through its capacity toremove the Certificate of GAP – Good AnimalPractice®; promotes continuous quality improve-ment within its organization through appropriate

RECOGNITION OF CCAC STANDARDS

On May 11, 2006, the President of the RoyalSociety of Canada (RSC), Dr. Patricia Demers,inquired whether continued representation onCouncil was a good and feasible idea, given thatanimal use is not a large domain within the RSC.On March 4, 2007, the Executive Director of theRoyal Society of Canada confirmed that the RSCdid not wish to continue to be represented on theCCAC Council.

On September 30, 2007, Council membersapproved the appointment of the CanadianVeterinary Medical Association (CVMA) to regularmembership on Council from a limited termappointment. At the same meeting Council alsoapproved the appointment of the CanadianFederation of Biological Societies as a limited termmember for a three-year term. Both appointmentswere effective April 1, 2008.

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feedback loops between policy generation, educa-tion and compliance activities; and is nationallyand internationally recognized and respected.

The Experts Committee’s recommended modelborrows several key elements of the CCAC model,detailed under the attributes and functions of theproposed Canadian Council for the Protection ofHuman Research Participants (CCPHRP), at a costfive times the annual budget of the CCAC.

Environment Canada (EC) and HealthCanada (HCan): New SubstancesNotification Regulations

The New Substance Notification Regulations areunder development by EC-HCan to replace thecurrent blanket research and development (R&D)exemption for organisms other than micro-organ-isms. In collaboration with the granting Agencies,the Association of Universities and Colleges ofCanada (AUCC) and members of the CCACBiotechnology Subcommittee, the CCAC devel-oped a list of 23 veterinarians, laboratory man-agers, researchers and senior administrators ofresearch institutions with backgrounds in scien-tific fields relevant to the objectives of the NewSubstances Notification Regulations (Organisms).The list was delivered to EC-HCan on October 18,2007 as part of the CCAC’s contribution to thepreparation of their December 5-6, 2007 secondworkshop on the proposed regulations. TheExecutive Director and Guidelines ProgramDirector also participated in a November 20, 2007teleconference with the workshop organizers to review the agenda and the appropriateness ofrepresentation.

The December 5-6, 2007 workshop included amuch broader representation of stakeholders like-ly to be impacted by the proposed amendments tothe regulations than had been present at the June 5-6, 2006 consultation. Representatives includedthose from the biomedical and biological fundingagencies, researchers using genetically-engineeredanimals (GEAs), directors of animal facilities hous-ing GEAs, companies engaged in commercializa-tion of GEAs, and representatives from the EC-HCan’s New Substance Program, as well asrepresentatives from other government depart-ments with a role in the regulation of genetically-engineered organisms.

The Phase II Discussion Document provided toparticipants prior to the workshop was a greatimprovement on previous discussion materials,and provided a useful framework for the consulta-tion. On February 12, 2008, the CCAC posted analert on the home page of its website with a link tothe Phase II Discussion Document, and sent an e-mail information capsule urging its constituents toforward comments on the Phase II DiscussionPaper to EC-HCan by February 29, 2008.

As a follow up to the December 5-6, 2007 work-shop, the Executive Director and the GuidelinesProgram Director were invited to participate in aFebruary 5, 2008 meeting of the funders of animal-based research, involving CIHR, NSERC, GenomeCanada and the Health Charities Coalition ofCanada, to define their collective views on issuesarising from the workshop. Future steps were dis-cussed with members of the CCAC BiotechnologySubcommittee at a February 5-6, 2008 meeting, inpreparation for a February 15, 2008 meeting calledby EC-HCan to receive the CCAC’s feedback onthe process to date, and to explore future collabo-rative involvement.

At the February 15, 2008 meeting with EC-HCan,it was agreed that a small expert working groupwas needed to classify organisms to be coveredby the notification system; the CCAC offeredassistance in identifying scientific experts. In par-allel to this, an initiative to bring national organi-zations in charge of confinement and contain-ment standards and guidelines together wasinitiated by the Canadian Food InspectionAgency (CFIA) in late March 2008. On the basis ofknowledge collected from these two activities, agap analysis will be conducted to ensure seamlesscertification for exemption from notificationwhere justified.

National Animal Health Strategy (NAHS)

The scope and new directions imparted by thismajor initiative were first described publicly in thefollowing excerpt from the May 20, 2007 speech ofthe Minister of Agriculture and Agri-Food Canadato representatives of the 116 other country mem-bers of the World Organization for Animal Health,formerly known as the Office International desEpizoties (OIE):

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“We are advancing a comprehensive andinclusive National Animal Health andWelfare Strategy. This will be a first for ourcountry. We want to enhance animal healthacross all sectors in Canada. This strategywill do that by integrating and aligning allthe principles, policies, and approachesthat guide public and private sector invest-ments and decisions on animal health andanimal welfare risk management, across allanimal populations, and their interfacewith the human population.”

The expansion of Canadian concerns from whatused to be limited to trade-related livestock animalhealth issues to include all sectors and animal pop-ulations and animal welfare is new. This is basedon the expansion of the definition of animal healthadopted by the OIE members in 2004 to includeanimal welfare.

The CFIA is the designated home for the NAHSSecretariat, which is under the direction of Ms.Johanne Beaulieu. A March 15, 2007 meetingbetween CCAC directors and Ms. Beaulieu, andthe participation of the CCAC Executive Directorin the June 5-6, 2007 Multi-partners Workshop onthe NAHS, led to an invitation to the CCAC to takean active part in the development of the strategy asit relates to animals used for scientific purposes. Inorder to provide expert advice in a timely mannerover the coming year, at its June 21, 2007 meeting,the CCAC Board of Directors agreed to the cre-ation of a CCAC Expert Working Group on theNAHS to provide expert opinion on all facets ofanimal use in science covered by the variousCCAC guidelines subcommittees.

Seven of the fourteen members of the CCACWorking Group on the NAHS participated in theSeptember 18-19, 2007 second Multi-PartnerWorkshop, held to determine the key focus areasthat should be addressed by the NAHS. TheWorkshop Report was released on December 19,2007 as a background document for the develop-ment of a draft discussion paper that outlinedvision statements, strategic objectives and strategicactions to reach those objectives for the thirdMulti-Partner Workshop, held on January 15-16,2008.

2. At the International Level

The CCAC monitors developments at the interna-tional level and entertains relationships with advi-sory and governing bodies and scientific societiesinterested in the use of animals in science. In addi-tion, as per the CCAC Five-Year Plan 2004-2009,the harmonization of international standards isamongst the top priorities of the CCAC GuidelinesProgram. The following are supporting activitiesundertaken by the CCAC.

International Council for Laboratory AnimalScience (ICLAS)

The Executive Director represented the CCAC atthe June 9, 2007 meeting of the ICLAS WorkingParty on Harmonization to revise the draft docu-ments produced by the ICLAS ad hoc committeeson Protocol Review and on animal user trainingprograms. This session was chaired by thePresident of ICLAS and CCAC AssessmentDirector, Dr. Gilles Demers. A session onGenetically-Engineered Animals held June 10, 2007in Como, Italy, was co-chaired by Drs. Demers andGilly Griffin. The Executive Director also partici-pated in the June 12, 2007 ICLAS InternationalConsortium meeting held in Como.

International Council for Laboratory AnimalScience (ICLAS) – Federation of EuropeanLaboratory Animal Science Associations(FELASA)

Drs. Demers, Gauthier and Griffin participated inthe 10th FELASA Symposium in Como, Italy onJune 11-14, 2007. Dr. Demers gave a presentationentitled Impact of Harmonization at the InternationalLevel, and Dr. Gauthier gave a presentation onNational Guidelines on Emerging Issues in Support ofInternational Harmonization.

American Association for Laboratory AnimalScience (AALAS)

Drs. Griffin, Michael Baar, Demers and Gauthierand Ms. Marie Bédard attended the 58th AALASNational Meeting in Charlotte, North Carolina inOctober 2007. With Drs. Denna Benn, University ofGuelph, Chris Harvey-Clark, University of BritishColumbia, and Tom Moon, University of Ottawa,they participated in a seminar on October 15, 2007

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on Best Practice Through Interpretation andImplementation of Canadian Animal Care and UseGuidelines on Fish, which was jointly organizedby the Canadian Association for LaboratoryAnimal Science (CALAS), the CanadianAssociation for Laboratory Animal Medicine(CALAM) and the CCAC.

Sixth World Congress on Alternatives andAnimal Use in Life Sciences (6WC)

Drs. Gauthier, Griffin and Demers, and Ms. AllisonGuy, the CCAC Research Fellow, attended the 6th

World Congress on Alternatives and Animal Usein the Life Sciences in Tokyo, Japan on August 21-25, 2007. The Executive Director chaired a session,Ethic Committees as an International Platform forCommunication and Action on Implementation ofthe 3Rs, and gave two presentations, TheInstitutional Animal Care Committee: Keystone ofInternational Harmonization and Public Participationin Informed Decision-making on Animal Use inCanada. Dr. Demers chaired the session onGlobalization – Validation & InternationalCooperation, and gave a presentation entitled TheImpact of International Harmonization of Guidelines onAnimal Welfare.

Seventh World Congress on Alternativesand Animal Use in Life Sciences (7WC)

The CCAC Executive Director accepted an invita-tion to join the Steering Committee for the 7WC, tobe held in Rome, Italy in August 2009.

Eighth World Congress on Alternatives andAnimal Use in Life Sciences (8WC)

As per the proposal tabled with members of theAlternatives Conference Trust (ACT) in 2005, the

Executive Director met with members of the ACTin Tokyo on August 24, 2007 to express the CCAC’sinterest in hosting the 8th World Congress onAlternatives & Animal Use in the Life Sciences inMontreal in August 2011. The CCAC’s offer wasaccepted.

3. Promoting the Principles ofthe Three Rs

On February 27, 2007, the Chair of the CCAC TaskForce on the Three Rs, Dr. Andrew Tasker, con-cluded his final report to the Board of Directors bysuggesting that “given the lack of personnelresources to support the Task Force, it may beappropriate to consider moving the Task Force to asubcommittee of the Guidelines Committee” toensure appropriate on-going support for furtherwork in the area of replacement, reduction andrefinement alternatives. At its September 2007meeting, the CCAC Board of Directors adopted amotion to strike a standing committee on the ThreeRs which was endorsed by the CCAC Council at itsMarch 10, 2008 meeting.

The CCAC hired an independent contractor torevise the Three Rs section of the CCAC website, asrecommended by the former Task Force on theThree Rs. Initiated on November 5, 2007, the workdelivered by early March 2008 included:

• a review of all materials related to Three Rsalternatives currently on the CCAC website,with rewrites where necessary; and

• a review of international websites on the ThreeRs with recommendations of material thatcould be linked from the CCAC website.

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RESULTS BY BUSINESS LINE

The activities conducted by CCAC’s four businesslines during Fiscal Year 2007-2008 are outlined inthe following section.

1. Assessment

The keystone to the CCAC Assessment Program isthe local animal care committee set up by each par-ticipating institution according to the Terms ofReference for Animal Care Committees established bythe CCAC. The CCAC Assessment Program,through a peer review process, is responsible foroverseeing the care and use of animals for scientif-ic purposes in Canada. Assessment visits are con-ducted by multi-disciplinary teams of experts andcommunity representatives.

1.1 Assessment Visits

Forty-six full assessment visits and twenty-five ini-tial/orientation/special/interim visits were com-pleted between April 1, 2007 and March 31, 2008.One institution from the private sector joined theCCAC Program in 2007-2008.

1.2 Assessment and Implementation Reports

Detailed reports are prepared following eachassessment visit, which may include recommenda-tions, where necessary, to improve animal care anduse to a standard in keeping with CCAC guide-lines. Sixty-four assessment reports were producedbetween April 1, 2007 and March 31, 2008, with anaverage production time of 8.3 weeks.

Institutions must submit implementation reportsto address the recommendations expressed in theirassessment report. In the past, delays in the pro-cessing of implementation reports have occurredwhen the Assessment Sector must request addi-tional information from institutions that have sub-mitted incomplete reports, or there is a lack of timeon the part of the assessment directors to reviewthe reports. Recruiting a manager of assessmentcommunications has considerably improvedimplementation report processing timelines and

helped the Assessment Sector work towards itsobjective of processing complete and satisfactoryimplementation reports within eight weeks (fromthe day a complete implementation report isreceived until the day the Certificate of GAP –Good Animal Practice® is sent to the institution),and providing feedback to all institution in a time-ly manner.

1.3 Additional Assessment Sector Activities

Policy for Senior Administrators

The CCAC policy statement for: senior administratorsresponsible for animal care and use programs is intend-ed to provide general guidance to senior adminis-trators responsible for animal care and use pro-grams by detailing their fundamentalresponsibilities in ensuring sound institutionalstandards of animal care and use. The policy wasapproved by Council in March 2008.

Revised Program Review Form

The CCAC Animal Care and Use Program ReviewForm (PRF) was originally developed primarily forlarger institutions that use animals in a laboratorysetting (most of the participants in the CCACProgram) but it has now been updated and adapt-ed for institutions with smaller animal-based pro-grams and for institutions that use fish, farm ani-mals or wildlife. The most recent draft of the PRFwas sent to 11 institutions for beta-testing and isbeing translated. Work is being actively undertak-en with IT consultants to ensure that a user-friend-ly, web-based version will be available to all insti-tutions. This will allow institutions to enterinformation on their animal care and use pro-grams, which will be transferred into a databasethat will be easily searchable and usable by theAssessment Sector.

Revision of the Assessment Program section on the CCAC Website

The structure and content of the AssessmentProgram section of the CCAC website was entirelyrevised as of September 2007. It is now more user-

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friendly, and includes additional information forpanel members, institutions being assessed andanimal care committee members.

Update on SharePoint

The Assessment Program site on the SharePointportal is now used to communicate withAssessment Committee (AC) members for allassessment-related business. AC members haverestricted access to the site, and can now reviewposted assessment and implementation reports.A different level of restricted access for panelmembers is currently being discussed. A newanimal use database has also been created on theportal to ensure a higher level of security for con-fidential information provided by institutions.With the implementation of appropriate securityfeatures, this new database could eventually beused by institutions to enter their own animaluse data.

CCAC Survey of Animal Use

The 2006 survey of animal use was posted on theCCAC website on December 20, 2007.

2. Guidelines

The delivery of the CCAC’s mandate is based onguidelines and policies which give clear directionto institutional animal care and use programs.Guidelines are developed and revised in responseto the current and emerging needs of the researchcommunity, advances in laboratory animal care,and the needs of the CCAC Assessment Program.

2.1. Guidelines Development

The following guidelines documents are currentlyunder development.

CCAC guidelines on: the care and use of farmanimals in research, teaching and testing

• Feedback from the final review is being incorpo-rated and this document is nearing completion.

CCAC guidelines on: genetically-engineeredanimals

• The second draft is currently being finalizingfor widespread review.

CCAC adopted guidelines on: euthanasia

• Feedback from the widespread review, whichconcluded on September 29, 2007, has beenevaluated by the subcommittee and is current-ly being incorporated into a final draft of theguidelines.

CCAC guidelines on: the care and maintenance of marine mammals

• Feedback from the widespread review, heldApril 16–June 15, 2007, is being incorporatedinto the document to produce the final draft.

CCAC guidelines on: the procurement ofanimals used in science

• After receiving Council approval in fall 2007,the document underwent a final translationand was published on the CCAC website inFebruary 2008.

CCAC adoption of Australian animal careand maintenance guidelines

• The subcommittee has reviewed the Australiancare and maintenance guidelines for rats as astarting point for developing CCAC guidelinesin this area.

2.2 Additional Guidelines Program Activities

Subcommittee functioning

The Farm Animals Subcommittee held a successfultwo-day meeting in Ottawa on April 17–18, 2007 toreach a consensus on outstanding issues andmoved toward a final draft of the guidelines.

Members of the Testing Subcommittee were invit-ed to a workshop involving representatives of theCCAC and six of Canadian regulatory agencies onApril 27, 2007 in Ottawa. The purpose of the work-shop was to gain a better understanding of the cur-rent requirements for animal use in support of riskassessment, and to discuss the impact of futuredirections, both nationally and internationally, onrequirements for animal use. The workshop initiat-ed a process to work toward agreement on com-mon objectives and action items regarding theactive and timely implementation of the Three Rs

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by regulators and the CCAC. Proceedings from theworkshop were sent to the Testing Subcommitteeand representatives of regulatory agencies whohad been invited to attend.

A Biotechnology Subcommittee meeting was heldon February 5-6, 2008 in Ottawa to reach consensuson outstanding issues in the draft guidelines, suchas the management of breeding colonies and theacquisition of information relating to the welfare ofgenetically-engineered animals. The subcommitteealso discussed actions to be taken in light of theproposed changes to the EC-HCan New SubstanceNotification Regulations (Organisms).

Guidelines implementation

The animal user training module on migratorybirds, developed by the Canadian Wildlife Service(CWS), has been finalized and is posted on theCCAC website in both official languages. Thespecies-specific recommendations on birds havealso been posted on the website.

International harmonization

The following international meetings were attend-ed by members of the Guidelines Sector:

• April 24-25, 2007 – meeting of the InteragencyCoordinating Committee on the Validation ofAlternative Methods (ICCVAM) in Bethesda,Maryland;

• June 11-14, 2007 – 10th Federation of EuropeanLaboratory Animal Science Associations(FELASA) Symposium in Como, Italy, andsatellite meeting for the ICLAS Working Groupon Harmonization of guidelines on genetical-ly-engineered animals;

• July 15-19, 2007 – International Congress ofToxicology meeting in Montréal, where a pres-entation on Implementation of the Three Rs inRegulatory Testing was given, and a poster,Discovery in Toxicology: Serving Society Throughthe Ethical Use of Animals in Regulatory Testingwas presented;

• August 21-25, 2007 – 6th World Congress onAlternatives and Animal Use in the LifeSciences in Tokyo, Japan, where presentationswere given: Facilitation of an International

Approach for Data Sharing and Acquisition inRelation to Genetically-engineered Animals;Categories of Invasiveness – a PrecautionaryApproach and Adopting Alternative Methods forRegulatory Testing in Canada; and a poster onIncentives and Impediments to AdoptingAlternative Shellfish Testing Methods in Canada;

• October 15-17, 2007 – American Association forLaboratory Animal Science (AALAS) meetingin Charlotte, North Carolina, where a presenta-tion on the CCAC fish guidelines was given;and

• November 2-3, 2007 – 4th annual meeting of theInternational Veterinary Academy of PainManagement (IVAPM) in Montréal, QC.

Interaction with the scientific community

The following scientific meetings were attended bymembers of the Guidelines Sector:

• May 10-11, 2007 – Colloque of the Associationfrancophone pour le savoir (ACFAS) in Trois-Rivières, QC;

• June 3-5, 2007 – CALAS Symposium in Calgary,AB, where the Guidelines Program Directorand the Past-Chair of CCAC Council, Dr. AlexLivingston, moderated the CCAC-sponsoredscientific session, Application of the Three Rs inAgricultural Research and Teaching, where fivemembers of the subcommittee on farm animalsgave presentations;

• October 18-20, 2007 – the CVMA AnimalWelfare Committee meeting in Saskatoon, SK;

• November 24, 2007 – meeting of le Réseau derecherche en transgenèse du Québec in Laval,QC; and

• November 16, 2007 – meeting of the NationalResearch Council Joint Committee on AnimalCare in Ottawa, ON, where a presentationtitled Developing guidelines on genetically-engi-neered animals was given.

2.3 CCAC Fellowship

A paper coauthored by the first research fellow,Ms. Julie Comber, and the Guidelines ProgramDirector was published in the Journal of Applied

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Animal Welfare Science (JAAWS): Comber, J. &Griffin G. (2007) Genetic engineering and otherfactors that might affect human-animal interac-tions in the research setting. JAAWS 10(3):267-277.

The second research fellow, Ms. Guy, was activelyinvolved in organizing the CCAC workshop withrepresentatives of Canadian regulatory agencies.She also visited the Interagency CoordinationCommittee on the Validation of AlternativeMethods (ICCVAM) and attended the InternationalCongress on Toxicology and the 6th WorldCongress on Alternatives & Animal Use in the LifeSciences where she delivered presentations andposters. Ms. Guy received the Young ScientistAward for her poster at the 6th World Congress.

Ms. Guy completed a course in qualitative meth-ods at the University of Ottawa. She finished col-lecting data for her case study on shellfish toxintesting and presented the results in a poster at theSociety of Toxicology meeting in March 2008. As afollow up to her success at the 6th World Congresson Alternatives & Animal Use in the Life Sciences,she authored two papers published in the proceed-ings. She also gave a presentation at the EuropeanCentre for the Validation of Alternative Methods(ECVAM) Workshop on the current Canadian reg-ulations, Three Rs Approaches in the Production andQuality Control of Fish Vaccines, and spent a week atECVAM to gain an understanding of the role ofECVAM in supporting EU legislation and policy.

3. Education, Training andCommunications

3.1 Training and Education3.1.1 National Institutional Animal User

Training (NIAUT) Program

A training module on migratory birds in research,prepared in collaboration with Canadian WildlifeServices, has been added to the CCAC website.

3.1.2 Workshops

The CCAC National Workshop 2007 was held onNovember 1, 2007 in Montréal, QC. A total of 240participants registered for the workshop. Feedbackfrom 126 of the participants is being used to pre-pare for the next CCAC National Workshop,

scheduled for early May 2009. This workshop willbe held in Ottawa, ON, and delivered over a twoday period to accommodate the growing numberof participants and topics to be covered.

The CCAC sponsored a scientific session onLaboratory Animal Pain Management at theNovember 2-3, 2007 joint congress of the Ordre desmédecins vétérinaires du Québec (OMVQ) and theInternational Veterinary Academy of PainManagement (IVAPM). Invited speakers includedDrs. Alex Livingston, University of Saskatchewan,Coenraad Hendriksen, Netherlands VaccineInstitute, and Paul Flecknell, University ofNewcastle, UK.

3.2 Communications

CCAC’s 40th Anniversary

An announcement celebrating the CCAC’s 40th

anniversary was posted on the website and a 40thanniversary poster was produced that was circu-lated to CCAC constituents as an insert in thespring 2008 special edition of RESOURCE.

Parliamentarians

The CCAC Annual Report 2006-2007 was madeavailable online and distributed electronically onSeptember 14, 2007. As in previous years, thereport was mailed to all federal members of parlia-ment and senators, with a cover letter explainingthe role of the CCAC and the national and interna-tional recognition of its standards, and offeringassistance with questions regarding animals usedin science in Canada.

Information capsules

Information capsules on the following subjectswere sent to constituents:

• April 18, 2007 – review of the draft CCACguidelines on: care and maintenance of marinemammals

• April 19, 2007 – review of the draft CCAC poli-cy statement for: senior administrators responsiblefor animal care and use programs

• May 31, 2007 – announcement of the CCACNational Workshop 2007 and the IVAPM/OMVQ Congress

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• June 1, 2007 – review of the draft CCAC policystatement for: senior administrators responsible foranimal care and use programs

• June 20, 2007 – review of the draft CCAC guide-lines on: care and maintenance of marine mammals

• August 8, 2007 – review of the draft CCACguidelines on: laboratory animal procedures –adopted guidelines on euthanasia

• August 23, 2007 - CCAC 2007-2008 servicesand fees

• October 5, 2007 – widespread review of theCCAC guidelines on: laboratory animal proce-dures – adopted guidelines on euthanasia

• October 9, 2007 – CCAC National Workshop2007

• December 20, 2007 – results of the 2006 AUDFsurvey

• February 12, 2008 – reminder to submit com-ments regarding the New Substance NotificationRegulations

• February 21, 2008 – CCAC guidelines on: pro-curement of animals used in science

Website

Quarterly website reports have confirmed a steadyincrease in traffic, with visits from other countriesincreasing at a faster rate than those from within

Canada. The most popular documents remainguidelines documents and the animal user train-ing modules.

4. Finance

On September 29, 2007 the Finance Committee(FC) reviewed and approved the 2006-2007 audi-tors’ report. The FC also reviewed the 2007-2008first quarterly report, and the expenses of theCCAC directors to ensure expenditures are kept ontarget.

The FC reviewed the report of April 1-August 31,2007 expenses by business lines (Assessments,Guidelines, and Education, Training andCommunications), and found that the informationoutlined gave a good sense of how the budget cov-ered each program.

The FC thoroughly reviewed the proposed three-year budget submitted in the December 14, 2007grant application. Members advised some adjust-ments be made to account for more realistic costincreases. The Chair of the FC met withDr. Gauthier on November 21, 2007 to further com-ment on the grant submission. He also participat-ed in the March 10, 2008 meeting with members ofthe NSERC-CIHR Evaluation Committee review-ing the CCAC’s grant submission.

Mark Evered, PhDChair (2007-2008), CCAC Council

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Species Total in 2006Amphibia 35,727

Cats 3,919

Cephalopods 24

Chinchilla 62

Dogs 9,552

Domestic Birds 116,691

Farm Animals 82,255

Fish 843,881

Fur Animals 2,047

Gerbils 1,516

Guinea Pigs 27,246

Hamsters 6,402

Marine Mammals 3,660

Mice 910,540

Miniature Swine 267

Non-Human Primates 4,363

Rabbits 18,152

Rats 331,560

Reptiles 6,019

Canadian Wild Species 131,858

Other Non-Canadian Species 248

Total 2,535,989

Total of Animals Used in 2006 per Species

APPENDIX ICCAC SURVEY OF ANIMAL USE – 2006

For more details, visit http://www.ccac.ca/en/Publications/New_Facts_Figures/intro.htm

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Scientific Members

* Mrs. Jo-Ann Aubut, Algonquin CollegeMr. John Batt, Dalhousie UniversityDr. Jocelyn Beaucher, Université de Sherbrooke

* Dr. Les Burridge, Fisheries and Oceans Canada, Maritimes RegionMs. Linda Campbell, Vanier CollegeMs. Suzanne Carioto, Centre hospitalier de l'Université de Montréal

* Dr. Catherine B. Chan, University of Alberta* Dr. Joseph Davison, University of Calgary

Ms. Élaine de Repentigny, Université du Québec à Trois-Rivières* Dr. Michel Flamand, Centre Hospitalier de l'Université Laval (CHUL)* Dr. Peter Flanagan, University of Western Ontario* Dr. Luc-Alain Giraldeau, Université du Québec à Montréal* Dr. Katherine Gottschall-Pass, University of Prince Edward Island* Mrs. Karen Gourlay, McMaster University

Ms. Ann Hogarth, Carleton University* Mr. Henrik Kreiberg, Pacific Biological Station, DFO* Dr. Edwin A. Kroeger, University of Manitoba* Dr. Pierre Lachapelle, McGill University* Mr. Philip Lavoie, McGill University, Macdonald Campus* Mr. Yvan Marineau, Université du Québec à Trois-Rivières* Dr. Sylvie Marleau, Université de Montréal* Dr. William Marshall, St. Francis Xavier University

Ms. Lisa Norton, Lakehead UniversityMs. Mary Panneton, Merck Frosst Centre for Therapeutic Research

* Dr. James Pfaus, Concordia UniversityMrs. Christine Quarrington, University Health NetworkMr. Martin Ryan, University of Waterloo

* Dr. Dan Rurak, University of British ColumbiaDr. Brian Talbot, Université de Sherbrooke

* Dr. Mark Torchia, Health Sciences Centre, University of Manitoba* Dr. Claire-Dominique Walker, McGill University

Mr. Norman White, University of Toronto

APPENDIX IIMEMBERS ON CCAC ASSESSMENT PANELS

* Identifies those members who have served as chairperson

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Canadian Federation of Humane Societies Representatives

Mr. Morris Airey, Edmonton, ABMr. Roch Bédard, Ste-Adèle, QCMs. Line Bélanger, Anagance, NBMr. David Buffett, St. John’s, NFMr. Hugh Coghill, Newmarket, ONMr. Martin Cole, Beaverton, ONMr. Shawn Eccles, Surrey, BCMrs. Susan Edwards, Elora, ONMs. Lise Gagnier, Le Gardeur, QCMrs. Carole Girard, Jonquière, QCMr. Darren Grendel, Newmarket, ONMr. Andrew Hebda, Halifax, NSMs. Lise J. Houde, Ste-Adèle, QCMs. Tracy Lapping, Sudbury, ONDr. James Lawson, Vancouver, BCMr. Serge Marquis, Trois-Rivières, QCMr. Robert J. Milling, Ottawa, ONMrs. Evelina Smith, Lennoxville, QC

* Mrs. Elizabeth Swanson, North Bay, ONMr. Claude Tétreault, St-Simon, QCMrs. Pam Tonary, Truro, NSMr. Robert Van Tongerloo, Manotick, ONMs. Lorna Verschoore, Winnipeg, MB

* Identifies those members who have served as chairperson

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Veterinarian Members

* Dr. Kate Banks, University of Toronto

* Dr. Craig Bihun, Institute for Biological Sciences, NRC Ottawa

Dr. Catherine Breault, LAB Research Inc.

* Dr. Ronald Charbonneau, Centre Hospitalier de l'Université Laval (CHUL)

Dr. Beverly Chua, University of British Columbia

* Dr. Wayne Cole, Ridgetown, ON (retired)

* Dr. Lucie Côté, INRS Institut Armand-Frappier

* Dr. Sylvia Craig, Dalhousie University

* Dr. Andrew Fletch, Consultant

* Dr. Jim Gourdon, McGill University

Dr. David G. Hanwell, University of Guelph

* Dr. Barb Hildebrand, Dalhousie University

Dr. David J. Hobson, University of Guelph

Dr. Gwendolyn Jeun, St. Clair College

Dr. Jenny Laing, Trent University

Dr. Mathias Leblanc, McGill University (now Salk Institute)

Dr. Marcus L. Litman, University of Guelph

Dr. Melissa L. Madden, University Health Network

Dr. Lynn Matsumiya, McGill University

Dr. Shelly A. McErlane, University of British Columbia

* Dr. Morag McMurray, Queen's University (now in private practice)

* Dr. Stéphane Ménard, Université de Montréal

* Dr. Badru Moloo, University Health Network

Dr. Douglas W. Morck, University of Calgary

Dr. Carol Morgan, University of British Columbia

* Dr. Patrick N. Nation, Animal Pathology Services Ltd.

* Dr. Patricia Turner, University of Guelph

Dr. Daphnée Veilleux-Lemieux, Université Laval

* Dr. Craig Wilkinson, University of Alberta

* Identifies those members who have served as chairperson

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APPENDIX IIICONTRIBUTORS TO THE GUIDELINES PROGRAM

Subcommittee on biotechnology

Dr. Bruce Murphy, Université de Montréal, Faculté de médecine vétérinaire (Chair)

Dr. Garth Fletcher, Memorial University of Newfoundland

Dr. Hélène Héon, Centre Hospitalier de l’Université de Montréal

Dr. Eike-Henner Kluge, University of Victoria

Dr. Harpreet Kochhar, Canadian Food Inspection Agency, Ottawa

Dr. Lauryl Nutter, Toronto Centre for Phenogenomics

Dr. Pascal Vachon, Université de Montréal, Faculté de médecine vétérinaire

Dr. Sui-Pok Yee, London Regional Cancer Centre

Subcommittee on farm animals

Dr. Tarjei Tennessen, Nova Scotia Agricultural College (Chair)

Dr. Laurie Connor, University of Manitoba

Dr. Anne Marie de Passillé, Agriculture and Agri-Food Canada, Agassiz

Dr. Ian Duncan, University of Guelph

Dr. John Feddes, University of Alberta

Dr. Marilyn Keaney, University of Ottawa

Dr. Harpreet Kochhar, Canadian Food Inspection Agency, Ottawa

Ms. Shelagh MacDonald, Canadian Federation of Humane Societies, Ottawa

Dr. Jeff Rushen, Agriculture and Agri-Food Canada, Agassiz

Dr. Fred Silversides, Agriculture and Agri-Food Canada, Agassiz

Dr. Kim Stanford, Alberta Agriculture Food and Rural Development

Dr. Marina von Keyserlingk, University of British Columbia

Subcommittee on laboratory animal care

Dr. Toni Bayans, University of Alberta

Dr. Sylvia Craig, Dalhousie University

Dr. Badru Moloo, University Health Network, Toronto

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Subcommittee on laboratory animal procedures

Dr. Ronald Charbonneau, Centre Hospitalier de l’Université Laval

Dr. Andrew Fletch, McMaster University

Dr. Lee Niel, University of Toronto

Dr. Ernest Olfert, University of Saskatchewan

Dr. Marina von Keyserlingk, University of British Columbia

Subcommittee on marine mammals

Dr. Jon Lien, Memorial University of Newfoundland (Chair)

Dr. Pierre-Yves Daoust, University of Prince Edward Island

Mr. John Ford, Fisheries and Oceans Canada, Nanaimo

Mr. Henrik Kreiberg, Fisheries and Oceans Canada, Nanaimo

Dr. Clément Lanthier, Calgary Zoo

Dr. Kay Mehren, Veterinarian Emeritus, Toronto Zoo

Ms. Tracy Stewart, Marineland of Canada Inc., Niagara Falls

Mr. Clint Wright, Vancouver Aquarium

Subcommittee on testing

Dr. Chris Banks, Charles River Laboratories Preclinical Services Montréal Inc.

Dr. David Blakey, Health Canada, Ottawa

Dr. Guy Chamberland, Victhom Human Bionics, Saint-Augustin-de-Desmaures, Québec

Dr. Ronald Charbonneau, Centre Hospitalier de l'Université Laval

Dr. Eileen Macallum, sanofi pasteur, Toronto

Dr. Pierre Tellier, Charles River Laboratories Preclinical Services Montréal Inc.

Dr. Patricia Turner, University of Guelph

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APPENDIX IVCCAC ORGANIZATIONAL CHART

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APPENDIX VMEMBERS OF THE CCAC STANDING COMMITTEES

Planning and Priorities Committee

Dr. Joseph Davison (Chair)

Dr. Kristina Bennett-Steward

Mr. David Buffett

Ms. Michelle Crawley

Dr. Alex Livingston

Dr. Jim Thornhill

Dr. Mark Evered (voting ex officio)

Dr. Clément Gauthier (ex officio)

Finance Committee

Dr. Jim Thornhill (Chair)

Ms. Michelle Crawley

Mr. Keith Marshall

Dr. Mark Evered (voting ex officio)

Dr. Clément Gauthier (ex officio)

Assessment Committee

Dr. Luc Chouinard (Chair)

Dr. Daniel Lamontagne

Dr. Suzanne MacDonald

Dr. Carol Morgan

Mr. Bill Pearce

Ms. Evelina Smith

(voting ex officio)

Dr. Mark Evered (voting ex officio)

Dr. Gilles Demers (ex officio)

Dr. Michael Baar (ex officio)

Ms. Marie Bédard (ex officio)

Dr. Clément Gauthier (ex officio)

Education, Training andCommunications Committee

Dr. Marilyn Keaney (Chair)

Dr. Anne Marie de Passillé

Dr. Sara Iverson

Dr. Thomas Moon

Mrs. Marielle Piché

Dr. Elliott Scott

Dr. Mark Evered (voting ex officio)

Dr. Clément Gauthier (ex officio)

Guidelines Committee

Mr. Henrik Kreiberg (Chair)

Dr. Toni Bayans

Dr. Douglas Crawford

Dr. Peter Greer

Dr. Eike-Henner Kluge

Dr. Donna Hutchings

Ms. N.A. Aedes Scheer

Dr. Marina von Keyserlingk

Dr. Mark Evered (voting ex officio)

Dr. Gilly Griffin (ex officio)

Dr. Clément Gauthier (ex officio)

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Board of Directors

Dr. Mark Evered Chair of Council

Mr. Stephen Bjarnason Vice-Chair of Council

Dr. Alex Livingston Past Chair of Council

Dr. Luc Chouinard Chair – Assessment Committee

Dr. Joseph Davison Chair – Planning and Priorities Committee

Dr. Marilyn Keaney Chair – Education, Training and Communications Committee

Mr. Henrik Kreiberg Chair – Guidelines Committee

Dr. Jim Thornhill Chair – Finance Committee

Dr. Clément Gauthier Executive Director (ex officio)

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Agriculture and Agri Food Canada (AAFC) Dr. Anne Marie de Passillé

Association of Canadian Faculties of Dentistry (ACFD) Dr. Elliott Scott

Association of Faculties of Medical Colleges (AFMC) Dr. Jim Thornhill

Association of Universities and Colleges of Canada (AUCC) Ms. Michelle Crawley

Dr. Mark Evered

Dr. Daniel Lamontagne

Dr. Suzanne MacDonald

Canada's Research Based Pharmaceutical Companies (R&D) Dr. Luc Chouinard

Canadian Animal Health Institute (CAHI)* Dr. Kristina Bennett-Steward

Canadian Association for Laboratory Animal Medicine (CALAM) Dr. Marilyn Keaney

Canadian Association for Laboratory Animal Science (CALAS) Dr. Toni Bayans

Canadian Bioethics Society (CBS) Dr. Eike-Henner Kluge

Canadian Council of Departments of Psychology (CCDP) Dr. Douglas Crawford

Canadian Federation of Humane Societies (CFHS) Ms. N.A. Aedes Scheer

Ms. Evelina Smith

Mr. David Buffett

Canadian Food Inspection Agency (CFIA)* Dr. Donna Hutchings

Canadian Institutes of Health Research (CIHR) Dr. Joseph Davison

Canadian Society of Zoologists (CSZ) Dr. Tom Moon

Canadian Veterinary Medical Association (CVMA)* Dr. Carol Morgan

Canadian Faculties of Agriculture and Veterinary Medicine (CFAVM) Dr. Marina von Keyserlingk

Dr. Alex Livingston

Department of National Defence (DND) Mr. Stephen Bjarnason

Environment Canada (EC) Mr. Keith Marshall

Fisheries and Oceans Canada (DFO) Mr. Henrik Kreiberg

Health Canada (HCan) Dr. David Blakey

Heart and Stroke Foundation of Canada (HSFC) vacant

National Cancer Institute of Canada (NCIC) Dr. Peter Greer

National Research Council (NRC) Ms. Marielle Piché

Natural Sciences and Engineering Research Council (NSERC) Dr. Sara Iverson

APPENDIX VICCAC MEMBER ORGANIZATIONS AND

REPRESENTATIVES

* Identifies limited term member

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APPENDIX VIICCAC SECRETARIAT CONTACTS

Administration SectorDr. Clément GauthierExecutive Directortel: 613-238-4031, ext. 24email: cgauthier@ccac.ca

Mrs. Rachelle FauteuxOffice Managertel: 613-238-4031, ext. 23email: rfauteux@ccac.ca

Ms. Tammy CheslockAdministrative Assistanttel: 613-238-4031, ext. 64email: tcheslock@ccac.ca

Ms. Annick LanglaisClerk/Receptionisttel: 613-238-4031, ext. 30email: alanglais@ccac.ca

Assessment SectorDr. Michael BaarAssessment Director andAssessment ProgramCoordinatortel: 613-238-4031, ext. 26email: mbaar@ccac.ca

Dr. Gilles DemersAssessment Directortel: 450-467-4221email: gdemers@ccac.ca

Ms. Marie BédardAssessment Directortel: 613-238-4031, ext. 29email: mbedard@ccac.ca

Ms. Maryse DansereauScientific Writer (until Oct. 2007)tel: 613-238-4031, ext. 28email: mdansereau@ccac.ca

Ms. Pascale BelleauScientific Writer (since Nov. 2007)tel: 613-238-4031, ext. 28email: pbelleau@ccac.ca

Mrs. Linda RhéaumeAdministrative Assistanttel: 613-238-4031, ext. 27email: lrheaume@ccac.ca

Ms. Tricia Abe Scientific Writer tel: 613-238-4031, ext. 62 email: tabe@ccac.ca

Ms. Jumoke Fasoyinu Manager of AssessmentCommunicationstel: 613-238-4031, ext. 33 email: jfasoyinu@ccac.ca

Guidelines SectorDr. Gilly GriffinGuidelines Program Directortel: 613-238-4031, ext. 25email: ggriffin@ccac.ca

Ms. Julie DaleGuidelines DevelopmentCoordinatortel: 613-238-4031, ext. 22email: jdale@ccac.ca

Mr. Marc-Alexandre BeaulieuScientific Translator/ResearchAssistant (until Oct. 2007)tel: 613-238-4031, ext. 34email: mabeaulieu@ccac.ca

Ms. Maryse DansereauScientific Translator/ResearchAssistant (since Oct. 2007)tel: 613-238-4031, ext. 34email: mabeaulieu@ccac.ca

Education, Training and Communications SectorMs. Claude CharbonneauCommunications Directortel: 613-238-4031, ext. 32email: ccharbonneau@ccac.ca

Ms. Emily VerlindenPublications Coordinatortel: 613-238-4031, ext. 31email: everlinden@ccac.ca