canary foundation luncheon presentation
TRANSCRIPT
Welcome
Canary Foundation Luncheon
Progress to Patients:
Canary’s 10 year journey from
tests to clinical trial
March 26, 2015
Strategy
Strategy – 10 years later
# 1 Most cancers take decades to develop
1p
IT
F01
INd
dtq1p = (IN + IT)-q1p x F01
IN + IT
(1-e-F01t)q1p =F01
ln(2)t1/2marker
qsts=[IN(mass/time) + IT(mass/time)]
Steady state can be calculated as:
# 2 Cancer generates measurable items in blood
# 3 But old technology can’t find it until too large
# 4 New nano-technology can find it 1000 times
smaller and 1000 times cheaper!
# 5 Models show we will save lots of lives
# 6 Tests will be cost-effective for high-risk patients
# 7 Finding new blood tests has been elusive
# 8 Molecular imaging is progressing at a rapid pace
# 9 World’s finest leadership
# 10 An unprecedented partnership with Stanford
# 11 And we have inspired global investment
CRUK
# 12 New tests and companies are coming to market
Cyrcadia health – Detected Movie Trailer
Scientific Panel
Sanjiv Sam Gambhir, MD, PhD – Chair, Department of Radiology,
Stanford University
Jim Brooks, MD - Chief, Urologic Oncology, Stanford University
Utkan Demirci, PhD - Associate Professor, Stanford University
Heidi Auman, PhD – Scientific Program Manager,
Canary Foundation
New
Ideas
$50K
Individual
1 year
New
IdeasClinical
Research
$10M
Team
10 years
$50K
Individual
1 year
New
IdeasClinical
Research
$20M
COE
7 years
$10M
Team
10 years
$50K
Individual
1 year
Science
New
IdeasClinical
Research
$20M
COE
7 years
$10M
Team
10 years
$50K
Individual
1 year
Facilities
Faculty
Associates
Science
Technology
$50M
Center
10 years
Science
New
IdeasClinical
Research
$20M
COE
7 years
$10M
Team
10 years
$50K
Individual
1 year
Facilities
Faculty
Associates
Science
Technology
$50M
Center
10 years
Science
Spin-outs
Medical device
Imaging tech
New
IdeasClinical
Research
Clinical
Trials
$20M
COE
7 years
$10M
Team
10 years
$50K
Individual
1 year
Facilities
Faculty
Associates
Science
Technology
$50M
Center
10 years
Science
Spin-outs
Medical device
Imaging tech
New
IdeasClinical
Research
Clinical
Trials
$20M
COE
7 years
$10M
Team
10 years
$50K
Individual
1 year
Facilities
Faculty
Associates
Diagnostic
Companies
Science
Technology
$50M
Center
10 years
Science
Spin-outs
Medical device
Imaging tech
Diagnostic test
Lung Cancer Breast Cancer
Molecular Imaging
Measuring densities of cells in real-time down to a single-cell level
31
Lab on a chip
Development of a Clinical Test Clinical Trials for CT + Biomarkers
CT + Biomarker Trial
initiated by MD Anderson
10,000 in US &
International
participation in China,
Germany, Brazil
Multiple techniques to analyze a
common set of samples
Integrate data and discover biomarkers
Smokers vs. Never Smokers
Cell Lines Tumors Blood
Pro-Surfactant Protein B (pro-SFTPB)
Validation
Lung cancer research & clinical trial
Novel strategy
Ovarian cancer clinical trial
PASS Clinical Trial
1,000+ Men
5 Year
Follow-upNo Progression
Suspected
Central
Bio-Repository
Progression Suspected
Option for Treatment
Tissue Resources for Validation
Tissue of 1,000+
men who have
had radical
treatment
500+ Non-recurrent cancer
500+ Recurrent cancer
1,000s of prostate cancer
tissues arrayed to maximize
rapid and efficient analysis
Prostate cancer clinical trial
Pancreas Blood test
Targeted Microbubble Ultrasound
Pancreas microbubble in mice
Ovarian microbubble
42
Motivation for TRUSPA Imaging of Prostate
TRUS guided prostate biopsy Sagittal Ultrasound Transverse Ultrasound
Photoacoustic imaging
Sagittal array
Transverse array
45
Pilot Clinical Trial: TRUSPA Imaging of Prostate
Prostate Capsule
Clinical Trials
Prostate Ovary Pancreas
$1,500 to sponsor 1 person
$3,000 to sponsor 2 people
$4,500 to sponsor 3 people
Thank You
Canary Luncheon Committee
Dear Pixels
Lobird
Laure Woods
Avaya
Union Bank
Village Doctors
William K Bowes Jr. Foundation
Franklin and Cathryn Johnson Family Foundation
Debbi Spungen in memory of Florence Spungen
Canary Challenge
Canary Challenge – September 26, 2015