cancer: are we losing the fight?

Integrative Health Version 20.14

Presented By:

Dr Don E. Harris

CancerWhy We Are Losing the Fight & What Can We Do to Change the Outcomes Through Diet, Daily Activities,

& Environmental Changes

Dr. Don E. Harris

Memberships and Associations:

• American Academy of Anti Aging Medicine (A4M)

• American Academy of Environmental Medicine(AAEM)

• American College for Advancement in Medicine (ACAM)

• American College of Sports Medicine (ACSM)

• American Nutraceutical Association (ANA)

• American Nutrition Association (ANA)

• American Society for Nutrition (ASN)

• American Society of Clinical Oncologists (ASCO)

• IDEA Health and Fitness Association

• Institute for Functional Medicine (IFM)

• International and American Society of Clinical Nutritionists ( IAACN)

• Society for Nutrition Education (SNE)

Post Doctural Education:

• Post Doc Fellowship: Integrative Cancer Therapy (Current)

• Certified Clinical Nutritionist 2014

• Certified Health Trainer

• Certified Cancer Exercise Trainer

Employment:

• University of Illinois at Chicago, Department of Oral Biology

• Harris Integrative Health & Nutrition, President

25 Years in Practice Specializing in Clinical Nutrition with

Emphasis on Integrative Cancer Therapies

Education:

• Bridgewater State College 1986

BS Biology

BS Psychology

• National University of Health Science 1992

BS Human Biology

Doctor of Chiropractic

• University of South Florida

MS Integrative Cancer Therapy 2014

Disclaimer

The information given and discussed at this workshop is for information and research

purposes only and is not intended to prescribe treatment.

An Integrative Health Care/Clinical Nutrition practice dedicated to assisting clients learn how

each individual can alter their Lifestyle

to live a life. Longer/Healthier

Harris Integrative Health & Nutrition

1) Understand the principles behind health issues facing our lives today and our future .

2) How these principles can positively affect our health and well being.

3) Prepare you to make informed decisions concerning your health

The Goal of Today's Workshop

4) Not to put you to sleep.

Common Conditions 2014

Neurococognitive Disorders

Alzheimer'sAttention Deficient DisorderParkinson’s ALSDementiaStroke

Endocrine DisordersDiabetesInsulin ResistanceThyroidHormone ReplacementAdrenal DysfunctionHormone Dysfunction

CardiovascularArteriosclerosisHeart AttackStroke

Gastro-Intestinal DisordersCrohn'sIBS Leaky GutDysbiosisEsophageal Reflux DiseaseUlcers/Ulcerative Colitis

Systemic DiseaseChronic FatigueFibromyalgiaAutoimmuneArthritisInflammationSexual DysfunctionMetabolic SyndromeCancer

Infectious DisordersViralBacterialFungalParasitic

Etiology for Most Diseases• Infections

• Inflammation

• Oxidative Stress

• Hyperglycemia

• Allergies

• Immune Dysfunction

• Angiogenisis, Apoptosis, Immune Function, Inflammation, pH, Free Radicals, Genetics, Altered Detoxification, Hormone Control, Energy Metabolism,

Dysbiosis, Cellular Communication , Genetics

• Acidosis

• Maldigestion

• Hormone Imbalances

• Dysbiosis

• Hypercoagulation

Physiology Related to the Development of Cancer

Symptom

Linear Approach to Healthcare

Treatment

We must begin to approach health care as a web-like environment, and not just a single cause mentality.

Digestion/Absorption

Detoxification/Elimination

Endocrine Dysfunction Immune/Inflammatory Imbalance

Web-Like Design

TreatmentSymptom

Symptom

Symptom

Cause Treatment

Treatment

Cause and Effect

RefinedCHOIngestion

Plasma Glucose

Insulin Secretion

Insulin ReceptorDown Regulation

Insulin Resistance Hypoglycemia HyperInsulinemia Syndrome XDiabetes Mellitus

Kidney Failure

Limb Amputation

Blindness

MI

Early DeathInsulin Resistance

PPAR gamma“thrifty gene Arthritis

Serotonin/ Endorphin Receptors

Weight Gain

Kidney Na Retention

Stress

CHO Hunger

Inflammation

Fatigue

Depression

Hypertension AGE

CV Risk

Pain

Blood Lipids

Cancer

Dysbiosis

Inter-Relationships of Disease

RefinedCHOIngestion

Plasma Glucose

Insulin Secretion

Insulin ReceptorDown Regulation

Insulin Resistance Hypoglycemia HyperInsulinemia Syndrome XDiabetes Mellitus

Kidney Failure

Limb Amputation

Blindness

MI

Early Death

RefinedCHOIngestion

Weight Gain

Fatigue

Depression

RefinedCHOIngestion

Insulin ResistancePPAR gamma“thrifty gene Arthritis

Inflammation

Pain

Cancer

Early Death

1LB

Illness Health

1LB

Balanced

Toxins

Symptoms

Proper Diet, Daily Activities, Environment

2LB

Illness Health

1LB

Toxins

Unbalanced

Symptoms

Inflammation


3LB

Illness Health

1LB

Toxins

Unbalanced

Symptoms

Inflammation


3LB

Illness Health

2LB

Toxins

Unbalanced

Symptoms

Inflammation


3LB

Illness Health

3LB

Toxins

Balanced

Symptoms


3LB

Illness Health

4LB

Toxins

Pro-Balanced

SymptomsAnti- Inflammation


More People are Going to Doctors Than Ever Before

More people are taking prescription and nonprescription drugs than ever before

More surgeries are being performed than ever before

More people are getting X-rays, diagnostic testing than ever before

More people have multiple sclerosis, lupus, crohns, RA , IBS, colitis, (auto-immune), than ever before

More people have acid reflux ulcers, and stomach problems than ever before

More women have menopause problems than ever before

More women have more frequent PMS and more severe PMS than ever before

More people suffer from allergies, asthmas, arthritis, migraine headaches than ever before

More people have diabetes than ever before

More people have pre-diabetic conditions than ever before

More people have heart disease than ever before

More people have chronic fatigue and fibromyalgia than ever before

More kids have attention deficit disorder and hyperactivity than ever before

More people have skin problems than ever before

More people have insomnia than ever before

More men and women suffer from sexual dysfunction and infertility than ever before

More people suffer from depression, anxiety, and stress than ever before

More People get Colds and flues than ever before

More men suffer from prostate problems and more women get yeast infections than ever before

Leading Causes of Death in the United States 1900 Infectious Illness

1.Pneumonia/Flu

2. Tuberculosis

3. Dysentery

4.Heart Disease

8. Cancer

7. Accidents

6. Kidney Infections

5. Stroke

10. Diphtheria

9. Senility

1.Heart Disease

2.Cancer

8. Pneumonia/Flu

5. Accidents

6. Alzheimer’s

9. Kidney Infection

4. Stroke

7. Diabetes

2011 Chronic Inflammation

70% 55%

2.2%

3.Chronic Lower RespiratoryAsthma, Bronchitis, Emphysema,

10. Self Harm

Life Expectancy 47 Life Expectancy 78

65 % of Deaths are Related to Poor Diet, Lifestyle, Environment

• Accidents 4.8%

• Cerebrovascular Disease (Stroke) 5.3%

• Pneumonia/Flu 2.2%

• Diabetes 2.8%

• Alzheimer’s 3.2%

• Kidney Disease 2.0%

• Self Harm 1.5%

• Chronic Lower Respiratory 5.6%

• Cancer 23.3%

• Heart Disease 25.6%

54.5%

Most Expensive Drugs (Billions) Chronic Disorders

• Lipitor $7.20 Cholesterol• Nexium $6.3 Heartburn• Plavix $6.1 Blood Clots• Advair $4.7 Asthma• Abilify $4.6 Antipsychotic• Seroquel $4.4 Antipsychotic• Singulair $4.1 Asthma• Crestor $3.8 Cholesterol• Actos $3.5 Diabetes• Epogen $3.3 Anemia

48 Billion 250 Billion

Most Prescribed Drugs (Millions) Chronic Disorders

• Hydrocodone (with acetaminophen) 131.2 Pain • Zocor 94.1 Cholesterol• Lisinopril (BP) 87.4 BP• Synthroid 70.5 Thyroid• Norvasc (BP) 57.2 BP• Prilosec (not OTC) 53.4 Antacid• Z-Pak/Zithromax 52.6 Antibiotic• Amoxicillin 52.3 Antibiotic• Glucophage (metformin) 48.3 Diabetes• Hydrochlorothiazide (BP) 47.8 BP

694 Million

- The age of a person expressed in terms of the period elapsed from the time of birth.

- The age of a person expressed in terms of the

physiological maturity of organs and systems.

Chronological Age

Biological Age

10 Biomarkers of Aging Tufts University

Strength

Muscle Mass

Basal Metabolic Rate (BMR/REE)

Fat Percentage

Aerobic Capacity

Blood Sugar Tolerance

Cholesterol/HDL Ratio

Blood Pressure

Bone Density

Temperature Regulation

50

Heredity accounts for one - quarter of the variation in human life expectancy. The other three quarters of this variation are based on the fact that, after the age of , genetic expression is influenced by lifestyle, environmental, and nutritional factors.

Heredity

http://www.google.com/url?sa=i&source=images&cd=&cad=rja&docid=WG3rQw06x6V4sM&tbnid=MuaV9w82kKA5hM:&ved=0CAgQjRwwAA&url=http://www.kenlauher.com/ask-ken/?Tag=Feng%20Shui%20Plants&ei=IJvdUburB87C4AOE6YHgBg&psig=AFQjCNFuDcvVsR9KyDZRX-r0JsgmYHEUUQ&ust=1373564064163901

http://www.google.com/url?sa=i&source=images&cd=&cad=rja&docid=WG3rQw06x6V4sM&tbnid=MuaV9w82kKA5hM:&ved=&url=http://bizarrocomic.blogspot.com/2010_04_01_archive.html&ei=IJvdUburB87C4AOE6YHgBg&psig=AFQjCNFuDcvVsR9KyDZRX-r0JsgmYHEUUQ&ust=1373564064163901

http://www.google.com/url?sa=i&source=images&cd=&cad=rja&docid=Fc9Jir1VEzXzJM&tbnid=_1Ap5FCJVdfS6M:&ved=0CAgQjRwwAA&url=http://www.blossomkhardt.com/plants.html&ei=o5vdUdL6IJfF4APZyICABQ&psig=AFQjCNGGoeLIly1M2B0GC2ohlYhg5WkdEQ&ust=1373564195580119

http://www.google.com/url?sa=i&source=images&cd=&cad=rja&docid=Fc9Jir1VEzXzJM&tbnid=_1Ap5FCJVdfS6M:&ved=&url=http://www.donnan.com/blog_3-4-08.htm&ei=o5vdUdL6IJfF4APZyICABQ&psig=AFQjCNGGoeLIly1M2B0GC2ohlYhg5WkdEQ&ust=1373564195580119

The heritability of life span is relatively minor. Our genes alter how our metabolism functions in response to certain environmental and lifestyle factors, which control our disease patterns and and our life expectancy.

We Inherit Genetic

Tendencies, Not Genetic

Certainties.

Heredity

Organ Reserve:

At a younger age organ reserve provides a margin of defense to people exposed to various stress related factors

As individuals age they lose organ reserve. A stress related factor can now exceed the ability of the organ to maintain homeostasis. This loss of organ reserve can develop into a pathological process.

Organ Reserve Biological Aging

Contributing Factors that can Modify Organ Reserve

1 Diet:A) Most RDA’s for vitamins and minerals (cofactors), are inadequate for

maintaining organ reserve in today’s environment.

B) Proper glucose regulation is a key factor in determining enhanced organ reserve.

C) Antioxidants are crucial in preventing free radical oxidative damage especially to mitochondrial DNA.

2 Environment:A) Stress increases production of hormones which can lead to altered cell

physiology.

B) Anxiety is physiologically similar to stress in it’s response.

3 Daily Activities:A) Increases in muscle mass and aerobic respiration are the two most

important controllable biomarkers related to organ reserve.

1) Increase in bone density2) Decrease in blood pressure3) Better control of glucose and cholesterol4) Increase in strength and REE

Altered TerrainTwo individuals are exposed to the exact same stimulus; bacteria, virus, toxin

One individual may develop an adverse responseInfection

DiseaseInflammation

One individual may not be affected at all

“The United States spends 3X more per person on health care than any other country, yet in DALE its care ranks in the world.”

World Health Organization

Disability-Adjusted Life Years

24th• WHO scientists have developed a new way of calculatingthe number of years that a person can be expected to live in full health.

• It is known as the DALE (Disability-Adjusted Life Years) system,and gives a truer picture of the health of a country than simplystudying death rates.

• To calculate DALE, the years of ill-health are weighted according to severity and subtracted from the expected overall life expectancy to give the equivalent years of healthy life.

"Basically, you die earlier and spend more time disabled if you're an American rather than a member of most other advanced countries."

Overall Male FemaleJapan 74.5 71.9 77.2Australia 73.2 70.8 75.5France 73.1 69.3 76.9Sweden 73.0 71.2 74.9Spain 72.8 69.8 75.7Italy 72.7 70.0 75.4Greece 72.5 70.5 74.6Switzerland 72.5 69.5 75.5Monaco 72.4 68.5 76.3Andorra 72.3 69.3 75.2San Marino 72.3 69.5 75.0Canada 72.0 70.0 74.0Netherlands 72.0 69.6 74.4United Kingdom 71.7 69.7 73.7Norway 71.7 68.8 74.6Belgium 71.6 68.7 74.6Austria 71.6 68.8 74.4Luxembourg 71.1 68.0 74.2Iceland 70.8 69.2 72.3Finland 70.5 67.2 73.7Malta 70.5 68.4 72.5Germany 70.4 67.4 73.5Israel 70.4 69.2 71.6United States of America 70.0 67.5 72.6

The Cost of Health Care in the United States

The Cost of Health Care in the United States

Obesity $92 Billion

United States spends 2.1 TRILLION on health care annually

United States spends $7,900/person on health care annually78%, or $2.1 trillion annually – are for the treatment ofpreventable, lifestyle related conditions such as type II diabetes,obesity, and heart disease.

United States spends 16% of GDP on health care annually

Australia spends 8.8% of GDP on health care annually

France spends 11.2% of GDP on health care annually

Sweden spends 9.2% of GDP on health care annually

Japan spends 8.2% of GDP on health care annually

Spain spends 8.2% of GDP on health care annually

GDP of the United States 14.3 Trillion

Diabetes $180 Billion Heart Disease $445 Billion Cancer $125 Billion

128 million 5.9 trillion/8.2% 483 billion $3,800/person

22.3 million 1.5 trillion/8.8% billion $/person

65 million 2.8 trillion/11.2% billion $/person

10 million 539 billion/9.2% billion $/person

47 million 1.6 trillion/8.2% billion $/person

Definitions:

Obesity: Having a very high amount of body fat in relation to lean body mass, or Body Mass Index (BMI) of 30 or higher.

• Body Mass Index (BMI): A measure of an adult’s weight in relation to his or her height, specifically the adult’s weight in kilograms divided by the square of his or her height in meters.

• In 1990, among states participating in the Behavioral Risk Factor Surveillance System, 10 states had a prevalence of obesity less than 10% and no states had prevalence equal to or greater than 15%.

• By 1998, no state had prevalence less than 10%, seven states had a prevalence of obesity between 20-24%, and no state had prevalence equal to or greater than 25%.

• In 2007, only one state (Colorado) had a prevalence of obesity less than 20%. Thirty states had a prevalence equal to or greater than 25%; three of these states (Alabama, Mississippi and Tennessee) had a prevalence of obesity equal to or greater than 30%.

By the NumbersObesity Trends Among U.S. Adults BRFSS 1990, 1998, 2007

1998

(*BMI 30, or about 30 lbs. overweight for 5’4” person)

2007

1990

No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30%

Obesity Trends Among U.S. Adults BRFSS 1990, 1998, 2007

(*BMI ≥30, or ~ 30 lbs. overweight for 5’ 4” person)

No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30%


Before1990


No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30%


1991 - 1998


No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30%


1999 - 2007

Approximate Grams Potential Calories

Carbohydrate Glucose in Blood and Interstitial Fluids 20 Glycogen Liver 85 Muscles 350

80 1,820 340 1,400

Fat (Assuming 15% Body Fat) 10,500 94,500

Protein 10,500 42,000

TOTAL 138,320

By the Numbers

Height/WeightBased on the North American Association for the Study of Obesity

Males5’ 00” 1225’ 01” 1265’ 02” 1315’ 03” 1355’ 04” 1395’ 05” 1445’ 06” 1485’ 07 1525’ 08” 1575’ 09” 1615’ 10” 1665’ 11” 1716’ 00” 1756’ 01” 1796’ 02” 1846’ 03” 1896’ 04” 195

Females4’ 10” 1144’ 11” 1185’ 00” 1215’ 01” 1245’ 02” 1285’ 03” 1315’ 04” 1345’ 05” 1375’ 06” 1405’ 07 1445’ 08” 1475’ 09” 1505’ 10” 1535’ 11” 1576’ 00” 161

15%-20%20%-25%

1. _____________ X __________ = ___________________ Unhealthy Weight 10(F) 11(M) Basic Calorie Needs (REE) (B)

2. ____________________ X______________ = _____________ Basic Calorie Needs (B) % Activity Level Activity Calorie Needs (A)

3. _________________ + ___________________ = _____________ Basic Calorie Needs (B) Activity Calorie Needs (A) (C)

4. ___________X .1 =________________ (C) Digestion Cal (D)

5. ________ + ________ + ________ = ___________________________ (B) (A) (D) TOTAL DAILY CALORIE NEEDS

How Many Calories

By the Numbers

Activity Level

Sedentary (20%) Sit, Drive, Stand Light Active (30%) Light WalkingModerately Active (40%) Dance, Exercise 3-4/Wk Very Active (50%) Exercise 4-6/Wk

175 10 1,750

1,750 35020%

1,750 350 2100

1,750 350 210

2100 210

2,310

1. _____________ X __________ = ___________________ Healthy Weight 10(F) 11(M) Basic Calorie Needs (REE) (B)

2. ____________________ X______________ = _____________ Basic Calorie Needs (B) % Activity Level Activity Calorie Needs (A)

3. _________________ + ___________________ = _____________ Basic Calorie Needs (B) Activity Calorie Needs (A) (C)

4. ___________X .1 =________________ (C) Digestion Cal (D)

4. ________ + ________ + ________ = ___________________________ (B) (A) (D) TOTAL DAILY CALORIE NEEDS

How Many Calories Do You Need?

By the Numbers

Activity Level

Sedentary (20%) Sit, Drive, Stand Light Active (30%) Light WalkingModerately Active (40%) Dance, Exercise 3-4/Wk Very Active (50%) Exercise 4-6/Wk

130 10 1300

1300 26020%

1300 260 1560

1300 260 156 1716

1560 156

By The Numbers

Total Daily Calorie Needs (A) __________

__________ X ___________________ Divided By 4 = __________________ (A) Calories/Carbs/Day(40%) Grams/Carbs

1716

1716 686 171

__________ X ___________________ Divided By 4 = __________________ (A) Calories/Protein/Day(30%) Grams/Protein

1716 514 128

__________ X ___________________ Divided By 9 = __________________ (A) Calories/Fat/Day(30%) Grams/Fat

1716 514 57

How Many Calories Do You Need?

Sarcopenia

•Muscle Loss

“ No decline with age is as dramatic or potentially more significant than the decline in . In fact, there may be no single feature of age-related decline more striking than the decline in Lean Body Mass in affecting ambulation, mobility, energy intake, intestinal function, overall nutrient intake and status, immune function, inflammatory control.”

Lean Body Mass

Total Weight Loss

Lean Body Mass

-11 -13

+4 -11

DSP OTC

Health Care Professional Vs. Over the Counter Weight Loss Programs

Inflammation

Inflammation • Cancer

• Chronic Lower Respiratory

• Cerebrovascular Disease (Stroke)

• Diabetes

• Autoimmune Disease

• Arthritis

• Alzheimer’s Disease• Fatigue

• Skin problems

• Heart Disease

Digestion

&

Absorption

Detoxification

&

Elimination

Immune

Dysfunction

Endocrine

Dysfunction

DIET

EnvironmentDaily Activities

Digestion & Absorption Detox & Elimination

Immune Imbalances Endocrine Imbalances

INFLAMMATION

INFLAMMATION

Inflammation

Chronic Inflammation

Systemic inflammation and the presence of pro-inflammatory proteins circulating in the blood stream, exerting their effects on tissues of the body generally.

Acute

Chronic

SystemicLocal

Definition: a protective response to injury in which blood vessels facilitate accumulation of fluid and leukocytes in extravascular tissue

Inflammation

Inflammation

Acute inflammation is a quick natural response of the host to tissue injuries and certain foreign injurious agents. The response is mediated by neutrophils and certain plasma proteins and other chemicals. The response is aimed at containing the injurious insult and repairing the damage. Neutrophils are recruited from blood to the site of injury in a series of steps beginning with the release of certain substances at the site of injury that help guide the neutrophils exodus. Acute inflammation may last for hours to several days

Inflammation is divided into acute inflammation, which occurs over seconds, minutes, hours, and days, and chronic inflammation, which occurs over longer times.

Acute Short duration (minutes-days) with emigration of fluid, plasma proteins, and into tissue.

ChronicLonger duration (days-months) with tissue accumulation of lymphocytes, plasma cells, & macrophages plus variable proliferation of

Inflammation & Immune Dysfunction

Inflammatory MarkersChemical messengers that coordinate and mediate the body’s response to injury and foreign invaders. These initial effects of the innate immune system are highly protective and necessary for survival.

Chemokines: Chemokines help immune system cells coordinate an attack against a foreign substance (such as a virus) that enters the body. Once a foreign substance has been identified in the body, white blood cells called macrophages release chemokines. The chemokines signal immune cells, such as T-lymphocytes and macrophages, to travel towards the infection and destroy the invading substance.

Interferons: Interferons help prevent viruses from replicating inside the body. Interferons stimulate natural killer (NK) T-cells to destroy body cells that have become infected with viruses or cancer. The NK T-cells have pouches, called granules, which are filled with chemicals that destroy infected cells on contact.

Interleukins: Interleukins are proteins that help regulate the inflammatory and immune responses by activating the body's white blood cells, such as T-lymphocytes. There are more than 20 known types of interleukins, which each have a unique functio

Tumor necrosis factor (TNF): Tumor necrosis factor (TNF) is a protein that stimulates the destruction of some types of cancer cells in the body. While macrophages are the primary producers of TNF, other cells, including red and white blood cells and cells that line the blood vessels, also release TNF. When cancer cells are detected in the body, TNF is released into the blood. The TNF then binds to the cancer cell, causing changes in the cell that ultimately lead to cell death.

Inflammatory Markers

• Accidents 4.8%

• Cerebrovascular Disease (Stroke) 5.3%

• Pneumonia/Flu 2.2%

• Diabetes 2.8%

• Alzheimer’s 3.2%

• Kidney Disease 2.0%

• Self Harm 1.5%

• Chronic Lower Respiratory 5.6%

• Cancer 23.3%

• Heart Disease 25.6%

54.5%

Chronic Inflammation

Your Diet, Lifestyle, and Environment can affect many aspects of your health but most importantly it increases in your body

Inflammation

INFLAMMATION

Inflammation

Show Animation on Bamboo Pad

Inflammation Bacteria and other pathogens enter the wound

Platelets from blood release blood-clotting proteins at the site

Mast cells secrete factors that mediate vasodialation and vascular constriction. Delivery of blood plasma, and cells to the injured area increases

Neutrophils secrete factors that kill and degrade patogens

Macrophages secrete hormones called cytokines that attract immune system cells to the site and activate cells involved in tissue repair

The inflammatory response continues the foreign material is eliminated and the wound is repaired.

Chronic Inflammatory DiseaseDigestion &Absorbtion

Detoxification & Elimination

Endocrine Imbalances

Immune/Inflammatory Imbalances

MouthStomach

Sm/Lg Intestines Liver

Pancreas/Gall Bladder

Liver & KidneysSkin

Small IntestinesBladderColon

PituitaryThyroid

/Adrenals Testes/Ovaries

Pancreas

ThymusLymph Nodes

White Blood CellsMacrophages

T-Cells

Minimal Chewing Digestive Enzyme Deficiency Dysbiosis/Periodontal Disease Leaky Gut Increased Sugar Intake

Increased Free Radicals Toxins Decreased EFA’s Stress

Exo/Endo Toxins Decrease Vitamin Intake Decreased Mineral Intake

Depression/Anxiety

Obesity

Sexual Dysfunction

Kidney/Liver Disease

Bowel Dysfunction/Inflammation

Cognitive Disorders

Arthritis

Neuro-Cognitive Disorders

Allergies

Daily Activities

Environment

Diet

Genetics Heart Disease

Cancer

Stroke

Lung Disease/Pulmonary Dysfunction

Diabetes/Metabolic Syndrome

Cognitive Disorders

Chronic Fatigue/Fibromyalgia

Auto-Immune Disease

Reproductive Disorders

Skin Disorders

Osteoporosis

Viral/Bacterial Infections

Digestion

&

Absorption

Detoxification

&

Elimination

Immune

Dysfunction

Endocrine

Dysfunction

Common GI Disorders

• Acid Reflux (GERD)• Bowel Obstruction• Celiac Disease• Constipation• Crohn’s Disease• Diarrhea• Diverticulitis• Gallstones• Gastritis• Irritable Bowel Syndrome• Pancreatitis• Peptic Ulcer• Ulcerative Colitis

• Aging also decreases the amount of Hydrochloric acid in the stomach

• By the age of 35 most people produce 1/3 the amount of hydrochloric acid

• Improperly digested food exists thestomach in an unusable form and can cause bowel dysfunction and dysbiosis

DYSALTERED

BIOLIFE

Inflammation Via the Intestinal Tract

• Decreased Digestive Enzymes

• Lipase• Protease• Amylase

• Altered Gastric pH• Dysbiosis

• Bacterial• Parasitic• Yeast

• Excitotoxins• Leaky Gut

If Proteins, Fats, and Carbohydrates aren’t broken down properly by digestive enzymes, opportunistic bacteria will benefit


• NSADs

• Food Allergens

• Intestinal Infection

• Parasites

• Maldigestion

• Malabsorbtion

• Ingestion of Chemicals

• Trauma

• Alcohol

• Radiation Therapy

• Aging


• Processed Foods

• High Glycemic Foods

• Decreased Protein Intake

• Pesticides

• Herbicides

• Saturated Fats

• Essential Fatty Acids

• Caloric Intake


Trans Fatty Acids

• Trans Fatty Acids find there way into brain tissue competing with the essential fatty acid DHA.

Found In:

French Fries Cookies

Corn Chips

CakesCandy

Potato Chips Mayonnaise

Tortilla Chips

Doughnuts

Margarine

Salad Dressing

Deep Fried Chicken

• Trans Fatty Acid inhibits the brain from producing DHA

Schmidt, M., Smart Fats, 2000

Partially Hydrogenated Fats

•Hydrogenation is the process of forcing hydrogen atoms into the holes of unsaturated fatty acids.

•Vegetable oil is too soft for margarine because it is a liquid. Saturated fat is too hard. Margarine requires something in the middle. “ So many different compounds can be made during the partial hydrogenation that they stagger the imagination. The end result is that many of these compounds are toxic to our systems.”

Dysbiosis

Digestive Enzymes

Protease Digestive Enzyme that breaks down protein

Amylase Digestive Enzyme that breaks down carbohydrates

Lipase Digestive Enzyme that breaks down fat

Pepsinogin, HCL, IF, Mucin, Lysozyme, Secretin, CCK

Digestion

&

Absorption

Detoxification

&

Elimination

Immune

Dysfunction

Endocrine

Dysfunction

For the first time in the history of the world, percent human beings are now subjected to contact with dangerous chemicals,

from the moment of conception until death. In the less than two decades of their use, the synthetic chemicals have been so thoroughly distributed

throughout the animate and inanimate world that they occur virtually everywhere.

100

Disorders Linked To Toxicant Exposure

• Chronic Fatigue Syndrome• Fibromyalgia• Multiple Chemical Sensitivity• Allergies, Asthma • Atherosclerosis

Disorders Linked To Toxicant Exposure

• Autoimmune Disease• Inflammatory Bowel Diseases• Endocrinopathies (Hypothyroid)• Reproductive Disorders • Chronic Dermatitis• Neurodegenerative Disorders• Autism

• Cancer

Common Signs & Symptoms Linked to Chronic Toxicant Exposure

• Recurrent headaches• Muscle aching & weakness• Paresthesias and

neuropathic pain• Recurrent infections• Infertility

Common Signs & Symptoms Linked to Chronic Toxicant Exposure

• Marked sensitivity to environmental chemicals, odors, medications, and/or nutritional supplements

• Chronic, debilitating fatigue & lethargy

• Depression, anxiety &/or mood swings

• Cognitive dysfunction (poor memory and concentration; learning disorders)

Amount of Toxic Chemicals Released into the

Environment Through 1994

• On-Site Land 4 Million Pounds

• Surface Water 25 Million Pounds

• Air 42 Million Pounds

• On-site Deep -well 40 Million Pounds

• Total Reported Release 111Million Pounds

• Total Estimated Release 2.2Billion Pounds

Xenobiotic Exposure

• Since WWII, between 75,000 to 80,000 new synthetic chemicals have been released into the environment; less than half have been tested for potential toxicity to adult humans

• Over 4 billion pounds of pesticides are used annually in the U.S. This amounts to 8 pounds for every man, woman, and child (EPA’s Office of Prevention, Pesticides, and Toxic Substances, 1999)

• Current law allows 350 different pesticides to be used on the food we eat

• The average home contains 3-10 gallons of hazardous materials • 400 synthetic chemicals can be found in the average human body

Xenobiotics & ToxicityCenter for Children’s Health & the Environment, Mt. Sinai School of Medicine

• Drugs are assumed to be toxic & must be proven safe (by

FDA standards) before they can be marketed. • There is no single regulatory agency that oversees industrial

chemicals to ensure their safety: industrial chemicals are presumed safe until proven hazardous, even though they may have physiological effects that are almost identical to a drug and are often manufactured by pharmaceutical companies.

• Any toxicity testing that is done typically involves individual compounds in highly controlled settings and almost never investigates effects of complex mixtures.

• Very little post-release safety monitoring occurs.

Phase I (Bioactivation)

• It is potentially more toxic than the parent toxin and therefore must be converted to a non-toxic, water–soluble molecule as soon as possible.

• In addition, this reaction also generates ROS directly as a spin-off product; therefore, dietary antioxidants can help protect tissue from damage that may occur by this reaction.

Phase II (Conjugation)

• In Phase II the biotransformed toxin is attached to a water soluble moiety via sulfation, glucuronidation, methylation, amino acid conjugation, glutathione conjugation, and acetylation.

• These reactions require an adequate amount of cofactors be continually replenished, since they are attached to a toxin and excreted.

• A great deal of energy is used and also must be replenished.

Balanced & Healthy Detoxification

• These two activities (Phase I and Phase II) work in concert, and must be balanced. In particular, Phase II must be able to keep up with Phase I generation of reactive intermediates.

• If a reactive intermediate is not immediately conjugated and removed it can act as a ROS and bind DNA, proteins, and RNA, causing irreversible damage to a cell.

Detoxification Enzyme Capacity is Highly Variable

• Many phase 1 enzymes are induced by their substrates.

• These are often xenobiotics.• This leads to more rapid production of reactive

intermediates.• Many substances including xenobiotics, drugs and

even nutrients (grapefruit) can inhibit some phase 1 enzymes.

• This inhibition leads to an accumulation of their substrates in the bloodstream and increased storage in fatty tissues.

Phase 2

• Phase 2 enzymes are highly dependent on energy and on adequate dietary protein.

• Phase 2 enzymes can be induced by numerous substances found in fruits, vegetables, spices and herbs.

• Both phase 1 and 2 are highly dependent on adequate nutritional status for their activity.

Causes of Impaired Detoxification: Summary

• Overwhelming toxic load exogenous + endogenous)• Impaired excretion (constipation or increased transit

time; renal dysfunction)• Inefficient fuels (macronutrient imbalance)• Deficiency of detoxifying substances (antioxidants,

cofactors, conjugating agents) • Genetic Variation

Why not just fast?

• Breakdown of adipose tissue (lipolysis) results in

surge of toxins into the circulation further

overloading already impaired liver function

• Lack of fiber impedes fecal excretion and increases

enterohepatic recirculation

• Insufficient calories impairs biotransformation

(detoxification is highly energy dependent)

The Problem with Fasting

• Fasting induces phase I enzymes--leading to overproduction of toxic intermediates

• Lack of exogenous antioxidants + depletion of endogenous glutathione = inadequate quenching of free radicals

• Lack of cofactors impairs phase II conjugation• End result: oxidative stress, inflammation, aggravation

of symptoms

Digestion

&

Absorption

Detoxification

&

Elimination

Immune

Dysfunction

Endocrine

Dysfunction

Characteristics that Identify Insulin Resistance

• Tendency to gain fat in the upper body• Menstrual irregularities and polycystic ovaries.• Marginally elevated LDL cholesterol.• Marginally elevated blood fats (triglycerides).• Marginally elevated blood pressure• A “sweet tooth.” • Symptoms that resemble hypoglycemia.• A family history of maturity - onset diabetes.

Characteristics that Identify Insulin Resistance

• Tendency to gain fat in the upper body

• Menstrual irregularities and polycystic ovaries.

• Marginally elevated LDL cholesterol.

• Marginally elevated blood fats (triglycerides).

• Marginally elevated blood pressure

• A “sweet tooth.”

• Symptoms that resemble hypoglycemia.

• A family history of type II diabetes.

Insulin Resistance and Inflammation

Whenever we're angry, scared, anxious, or tense, the brain produces cortisol and adrenaline: hormones specifically designed to incite the fight-or-flight response that was once crucial to our survival. Adrenaline's main role is to make you alert and focused, with exceptional concentration and memory. Cortisol helps increase heart and respiratory rates and getting your muscles tensed and ready. Since, physiologically speaking, your body thinks you've run a mile or two or done something active in response to the 'threat', the hormone sends signals to refuel the body as soon as possible. It's a biological green light to indulge in foods loaded with carbs and fat that leads to weight gain in the chronically stressed. It's a vicious cycle of stress, followed by elevated cortisol, followed by that foods you don't need.

While those physiological processes worked well for our prehistoric ancestors, they're not as useful in a world where physical dangers are seldom. The trouble is, whenever we're stressed these hormones are released into your system. Though adrenaline levels plummet as the stress subsides, cortisol remains in the body much longer. Your liver and muscles are not able to remove the increased blood sugar due to the increased cortisol. This also increases the output of insulin causing a condition known as insulin resistance. Research has found that fat cells deep inside the belly are especially good at attracting cortisol. Simply put, the cascade of responses caused by stress encourages the accumulation of excess 'stress fat', the layer of fat below the abdominal muscle. 'This creates "toxic weight" - or extra fat inside the abdomen - which is the only type of fat on the body associated with death. This type of fat has been linked to heart disease, high blood pressure, stroke, cancer and diabetes.


Your liver and muscles are not able to remove the increased blood sugar due to the increased cortisol. This also increases the output of insulin causing a condition known as insulin resistance. Research has found that fat cells deep inside the belly are especially good at attracting cortisol. Simply put, the cascade of responses caused by stress encourages the accumulation of excess 'stress fat', the layer of fat below the abdominal muscle. 'This creates "toxic weight" - or extra fat inside the abdomen - which is the only type of fat on the body associated with death. This type of fat has been linked to heart disease, high blood pressure, stroke, cancer and diabetes.


Metabolic syndrome begins years before obesity appears; millions of people who are not obese have metabolic syndrome, while nearly everyone who is obese or diabetic has metabolic syndrome.

Insulin Resistance and InflammationMetabolic Syndrome

This state of persistent increased levels of cortisol leads into insulin resistance. This is usually called metabolic syndrome, although some experts call it Syndrome X or prediabetes.

Insulin resistance occurs when cells become insensitive to the insulin message. When cells don’t respond effectively to insulin, blood sugar is not properly managed, and the pancreas is required to secrete more insulin. When insulin levels in the blood become very high, they influence gene expression, altering cellular effects and promoting accelerated aging.


The connection between life span and the hormone insulin is extraordinary.

Control of blood sugar and its companion hormone insulin is a major point of investigation because insulin plays a principal role in communicating with the genes and altering their expression

• 36% of HMO expenditures are related to diabetes

• Insulin Resistance may affect as many as 25% of the non obese, non diabetic population. 60 million Americans

• Annual Morbidity and Mortality of Diabetes in the US

• 12,000-24,000 new cases of blindness• 54,000 amputations• 178,000 deaths


How Cellular Energy Comes From FoodCarbohydrates

Simple (Mono) Simple/Complex (Di) Complex (Poly) Fiber (Cellulose)

Energy Glycogen (stored) Triglycerides (liver) VLDL’s Adipose

Glucose

Carbohydrates and Inflammation

Sugar Fruits Veggies Breads/Cer Beans

20m 30m 40-50m 45m-90m 90m-180m

Glycemic Index


Types of Food Food Preparation Interfering Factors

Inadequate Supply of Dietary Nutrients

Depletion of Body Stores of Nutrients

Biochemical Abnormalities

Pathological Changes in Cells and Tissues


Excess intake of food

Increase in blood sugar

Increase in insulin production

Insulin Resistance ( Syndrome X )

Switched Metabolism

Obesity, Fatigue, Cognitive Problems, Diabetes, Cancer, Cardiovascular, AD/HD

CHILDHOOD RELATED DISORDERS


• Sugar is one of the most important nutrients for bacteria.

• If levels of sugar are increased in the GI tract, unfriendly bacteria feast off the sugar which can lead to increased levels of “unfriendly” bacteria in the intestines

• Increased bacteria release excess byproducts which can cause gastrointestinal problems and systemic illnesses such as:

Over Consumption of Sugar

Heart Disease

Arthritis

Neurocognitive Disorders

Allergies


Cancer

Endocrine Dysfunction:The Role of Stress/Inflammation

AdrenalsThyroid

Sex Hormones

Hormones are chemical substances, produced in the body by an organ or cells of an organ which has a specific regulatory effect on the activity of a certain organ or organs.

Top Hormones

• TSH, T3, T4

• Insulin

• Glucagon

• DHEA

• Cortisol

• Human Growth Hormone

• Testosterone

• Estrogen

• Progesterone

Estrogen Produced in the ovaries and adrenal glands.

Stress

Adrenal glands stop producing estrogen and produce the stress hormone cortisol.

More difficult transition into menopause.

May require more medications and early hormone replacement therapy.

Top Hormones

What Constitutes “Stress?• “Fight or flight” responses; fear, anxiety, worry• •Depression, feelings of defeat or helplessness• •Pain syndromes• •Infection, inflammation• •Hypoglycemia• •Inadequate sleep• •Disrupted light cycles• •Toxic exposure

The Stress Response

“Overwhelmingly, it is psychological rather than physiologic stress which has the capacity to elevate and maintain the stress response chronicallycausing disease consequences.”

Sapolsky, R.M., Stress, Stress related Disease, and Emotional Regulation. In J. Gross (Ed.), Hand Book of Emotional Regulation. (pp. 606-615).New York, Guilford, 2007

• Disruptions in homeostasis (i.e., stress) place demands on the body that are primarily met by the activation of 2 systems:

the hypothalamic-pituitary-adrenal (HPA/HPT) axis the sympathetic nervous system (SNS)

•Stressor-induced activation of the HPA axis and the SNS results in a series of neural and endocrine adaptations known as the “stress response” or “stress cascade.”

The Stress Response

The Stress Response

“Every stress leaves an indelible scar, and the organism pays for its survival after a stressful situation by becoming a little older.”

Hans Selye, MD, PhD

The Stress ResponseRapid Pulse

General Irritability

Dryness of the Throat & Mouth

Inability to Concentrate

Sleep Disturbances

Headaches

Decreased Immune Response

Fatigue of Unknown Origin

Anxiety/Depression

Weakness/Dizziness

Diarrhea/Indigestion

Decreased Testosterone/Estrogen

Trembling/Nervous Ticks

Sexual Response/Reproduction

Increase Cholesterol

Stress Response

Flight or Fight Syndrome

Stress (emotional/Physical)

Flight Fight

General Adaptation Syndrome


AdrenalsThyroid

Sex Hormones

It is questionable whether the decline in these hormones to levels that reduce quality of life and functional ability is a natural consequence of aging or as a result of altered gene expression through poor choices in lifestyle, diet and environment.

Sex Hormones

Estrogen Dominance

Cervical Dysplasia

Uterine Fibroids

Risk of Endometrial Cancer

Fibrocystic Breast Disease

Risk of Breast Cancer

Thyroid Dysfunction

Fat Gain

Water Retention

Fatigue

HeadachesDepression with Anxiety or Agitation

Sex Hormones

Why Estrogen Dominance Exists

Pesticides

Hormones in Meat

Plastics

Aromatase

Premarin

Lifetime Estrogen Exposure

Sex Hormones

Balance

Each woman is an individual and hormonal balance must be the ultimate goal. All three major hormones, estrogen, progesterone and testosterone need to be in balance in order for menopause to be a healthy transition rather than a debilitating struggle.

Sex Hormones

Adrenopause Symptoms

Women Versus Men

Reduced Libido Reduced LibidoDisturbed Sleep Disturbed SleepDepression Depression

Irritability Irritability

Fatigue Fatigue

Heart Disease Atherosclerosis Heart Disease AtheroThinning Skin Thinning Skin

Slow Wound Healing Slow Wound Healing

Osteoporosis Osteoporosis

Reduced Estrogen/Progesterone Reduced Testosterone

Irregular Menstruation Erectile Dysfunction

Hot Flashes Ejaculatory Problems

Sex Hormones

• Like testosterone, estrogens are also growth promoting hormones.

• One of estrogens primary roles is the stimulation of growth and proliferation of the endometrial lining of the uterus and cells of the breast in preparation for pregnancy and lactation.

• Estrogens accomplish this by stimulating estrogen receptors located on cells at these sites…Estrogens enlarge the pool of target cells that may become cancerous.

• Estrogens may also promote the growth of already established cancer

Sex Hormones

Estrogen Functions Progesterone FunctionsSecondary Sex DevelopmentPrevents OsteoporosisReduces Hot FlashesReduces Vaginal Dryness/ThinningMaintains Muscle MassMaintains StrengthPrevents Heart DiseasePrevents StrokeReduces CholesterolFeeling of Well BeingImproves SleepImproves Concentration and MemoryPrevents Alzheimer’sImproves Libido

Buttresses the effects of EstrogenPrecursor of Sex HormonesMaintains Uterine LiningEmbryo/Fetal SurvivalProtects Against Fibrocystic BreastDiureticFat Burning ThermogenisisAntidepressantFacilitates Thyroid HormoneNormalizes Blood ClottingSex DriveBlood Sugar SupportCancer Protection

EndometrialBreast

Promotes Osteoblastic Bone

Sex Hormones

Endocrine Dysfunction:The Role of Stress

AdrenalsThyroid

Sex Hormones

Adrenal Dysfunction:The Role of Stress

• Challenge the body to increase hormones by the use of precursors to increase functional organ reserve.

• Depending on what we are thinking or feeling or feeling our mind can change our hormones.

• According to Dr. Sears, Control of hormones equates to control of Aging.


Adrenal Dysfunction:Pathophysiology

• The adrenal glands produce the hormones

cortisol and DHEA.• Over secretion of cortisol triggered by daily

stress from work, family or other sources

can wear down the internal system and• During this process DHEA may be

compromised, causing other functions to

suffer. cause fatigue.

General Adaptation SyndromeStress controls the release of cortisol

AlarmCorticosteroids

Resistance

Corticosteroids

Altered Glucose Tolerance

Blood Pressure/Heart Rate

Adrenal/Thyroid DysfunctionSex Hormone Alterations

Exhaustion The Stress Response

CholesterolCatabolism

HPA/HPT Axis

THE STEROIDOGENIC PATHWAYS

THE STEROIDOGENIC PATHWAYS

Cortisol & DHEAderive fromthe same precursors

STRESS

“Cortisol Steal” When you’re continuously making stress hormones your body will decrease production of sex

hormones, as well as aldosterone, this is called cortisol steal. Lower sex hormones will lead to hormonal imbalances such as irregular menstrual cycles, infertility and low libido. Lower aldosterone levels will prevent your kidneys from absorbing sodium and therefore spilling sodium into the bladder. Wherever sodium goes, water follows. This will cause dilute urine and frequent urination, as well as the craving of salt.

Higher cortisol levels also block the 5’ deiodinase enzyme. This enzyme is responsible for the conversion of the thyroid hormone T4 which is made in the thyroid, to T3, which is converted primarily in the liver and kidneys. When this enzyme is blocked it will increase the production of reverse T3. T3 is the thyroid hormone which has the most effect on the body. Therefore, when cortisol blocks this enzyme it will lower thyroid function, which leads to lower metabolism and weight gain. This could be one of the reasons people have symptoms of a low thyroid, but their TSH (thyroid stimulating hormone) is normal, as well as T4. The T3 and reverse T3 levels are rarely checked.

Stress will also have effects on the gastrointestinal tract. It will decrease hydrochloric acid (stomach acid) and mucus production, slow the motility of the small intestine and increase the motility of the large intestine. When you have a decrease in stomach acid and mucus production, this will decrease the amount of gastric protection of the stomach. The high cortisol levels from stress will decrease immune function, therefore making it a favorable environment for Helicobacter Pylori to proliferate, and causing a gastric ulcer. If the small intestine is slower to recover from stress the motility is impaired and constipation results. When the large intestine is slower to recover from stress, motility is increased and diarrhea results.

Adrenocorticol Hyperactivity• Life-saving in the short-term! (catabolism frees

up energy reserves)

• Persistent cortisol production immune• suppression, hyperglycemia, insulin resistance,• central adiposity, hypertension, memory• impairment (hippocampal damage),• hyperlipidemia, impaired hepatic T4 T3 • conversion

Corticosteroids are group of natural and synthetic analogues of the hormones secreted by the hypothalamic-anterior pituitary-adrenocortical (HPA) axis, more commonly referred to as the pituitary gland. These include glucocorticoids, which are anti-inflammatory agents with a large number of other functions; mineralocorticoids, which control salt and water balance primarily through action on the kidneys; and corticotropins, which control secretion of hormones by the pituitary gland.

Adrenal Dysfunction:Pathophysiology

The principal glucocorticoid hormone is cortisol, which regulates the metabolism of proteins, carbohydrates, and lipids. Specifically, it increases the catabolism or breakdown of protein in bone, skin, muscle, and connective tissue. Cortisol also diminishes cellular utilization of glucose and increases the output of glucose from the liver.

Because of their effects on glucose levels and fat metabolism, all the glucocorticoids are referred to as anti-insulin diabetogenic hormones. They increase the blood sugar level, raise the concentration of plasma lipids, and, when insulin secretion is insufficient, promote formation of ketone bodies, thus contributing to ketoacicidosis.

Other physiologic processes within the body can occur only in the presence of or with the “permission of€” the glucocorticoids. For example, the secretion of digestive enzymes by gastric cells and the normal excitability of myocardial and central nervous system neurons require a certain level of glucocorticoids.

Glucocorticoids also promote transport of amino acids into the extracellular compartment, making them more readily available for the production of energy. In times of stress the glucocorticoids influence the effectiveness of the catecholamines, dopamine, epinephrine, and norepinephrine. For example, the presence of cortisol is essential to norepinephrine-induced vasoconstriction and other physiologic phenomena necessary for survival under stress. This particular property of cortisol demonstrates the one identifiable relationship between hormones from the adrenal cortex and those from the adrenal medulla. One of the medullary hormones is norepinephrine, which is secreted in large quantities when the gland is stimulated by the sympathetic nervous system in response to stress.

Another effect of cortisol is that of dampening the body's inflammatory responce to invasion by foreign agents. When present in large amounts, cortisol inhibits the release of histamine and counteracts potentially destructive reactions, such as increased capillary permeability and the migration of leukocytes. Since the immune responce can damage body cells as well as those of foreign agents, the antiinflammatory protective mechanisms of cortisol help preserve the integrity of body cells at the site of the inflammatory response.

Adrenal Dysfunction:

Actions of Cortisol – Catabolic

• Maintains blood glucose levels during stress reactions (gluconeogenesis) additional glucose to brain, heart, lungs, skeletal muscle.

• Promotes hepatic protein synthesis and gluconeogenesis; stimulates protein catabolism elsewhere in body.

• Stimulates glycogenolysis, lipolysis

• Participates with aldosterone in Na reabsorption• Anti-inflammatory – downregulates phospholipase A2, inflammatory cytokines

• Inhibitory feedback to hypothalamus and pituitary downregulation of CRH and ACTH

• Cortisol highest in a.m., with gradual decline over course of day; normal diurnal curve indicates healthy adaptation to stress

Actions of DHEA – Anabolic• Prohormone for sex steroids• • Anti-glucocorticoid• • Immune supporting• • Anti-atherogenic, lowers serum triglycerides• • Enhances insulin sensitivity; anti-obesity effect• • Maintains tissue strength and repair, supports• bone density• • Neuroprotective; enhances memory• • Promotes sense of well-being

Endocrine Dysfunction:The Role of Stress

AdrenalsThyroid

Sex Hormones

Thyroid Dysfunction:The Role of Stress

HPA/HPT Axis

Signs of Low Thyroid Function• Dry skin, elbow keratosis, brittle nails

• Diffuse hair loss

• Puffy face, swollen eyelids; edema in legs, feet, hands

• Elevated cholesterol, generally LDL

• Easy bruising

• Prolonged Achilles tendon reflex

• Keratoderma

• Enlarged thyroid gland

Symptoms of Low Thyroid Function

• Fatigue, usually persistent, especially on waking;

less toward the evening

• Cold intolerance, with cold extremities

• Slow speech, movement, heart rate

• Morning stiffness, arthralgias, muscle pain/cramps, particularly in calves, thighs, and

upper arms

• Memory concentration problems

• Diffuse headache, migraines

• Depression; melancholia

• Constipation: hard bowel movements and decreased frequency

• Low libido

• Reactive hypoglycemia

Symptoms of Low Thyroid Function

Top 10 Signs and Symptoms whenSuspecting Suboptimal Thyroid Function

• 1. Fatigue• 2. Weight Gain• 3. Feeling Cold• 4. Dry Hair and Skin• 5. Hair Loss• 6. Menstrual Irregularities• 7. Edema• 8. Muscle Aches and Joint Pain• 9. Constipation• 10. Depression

Hypothalamus

HPA/HPT Axis

Liver/Kidney

TRH Pituitary

TS

H

Thyroid Gland95% T4

5%T

3

Cell NucleusrT3

(Inactive)

T3

(Active)85%

(5 Deidodinase)

Hypothalamus

HPA/HPT Axis

Liver/Kidney

TRH Pituitary

TS

H

Thyroid Gland95% T4

5%T

3

Cell NucleusrT3

(Inactive)

T3

(Active)85%

Stress

Digestion

&

Absorption

Detoxification

&

Elimination

Immune

Dysfunction

Endocrine

Dysfunction

• Free Radical Damage

• Stress

• Too Much or Too Little Exercise

• Poor Nutrition

• Medications

• Toxins

• External

• Poor Liver Detoxification

Causes of a Dysfunctional Immune System

Serum proteins which are induced following contact with antigen. They bind specifically to the antigen which induced the formation.

Are any molecules which are recognized by the immune system and induce an immune response.

In a healthy immune system antibodies are produced in response to antigens entering the body via lungs, digestive tract and skin, or are produced by contact with internal invaders such as cancer cells.

In an unhealthy immune system antigens are not fought off and are free to cause damage and cancer cells are not destroyed and could lead to cancer.

Antibody

Antigen


Hyper Active Internal Hyper Active External

Hypo Active Internal Hypo Active External

Auto Immune Allergies

Cancer Colds/Infections

Systemic Lupus Erythematosus

Rheumatoid Arthritis

Multiple Sclerosis

Many Autoimmune Diseases are rare, but together they affect 24 million people in the United States

More than 40 autoimmune conditions have been identified. Together they constitute the third leading cause of sickness and death after Heart disease and cancer.


Free Radicals and Autoimmunity

If the organs of your body are not defended by sufficient anti-oxidants against oxidative stress, they lose function over time, and their ability to produce hormones or control immune function is lost. After several years , free radical-induced organ damage can result in the appearance of “twisted molecules”. These unnatural twisted molecules can activate the body’s immune system to combat misidentified foreign invaders, resulting in damage to organs like the thyroid.

Jeffrey S Bland, Ph.D.

Autoimmunity and Inflammation

As one ages with a poor immune system the body can begin to attack itself.

• Thyroid As the body begins to destroy this gland, T3 and T4 are diminished. The result is low energy, poor muscle function, altered digestive function, constipation, hair loss, loss of skin integrity, menstrual irregularities and alterations in heart function.

This suggests that an important feature of healthy aging is to prevent the body from becoming allergic to itself and from developing autoimmunity.

Autoimmunity and Inflammation

Conditions linked to Food Allergy

• Irritable bowel syndrome• Migraines• Auto-immune diseases• ADHD and behavior disorders• Enuresis and incontinence• Joint pains

Every receptor found in theCNS is also found on immune cells

Every thought and every chemical that effects the CNS will effect the immune system

Arthritis

Inflammatory bowel disease

Auto-immune diseases

Eczema

Asthma

Atherosclerosis

Cardiovascular disease

EFA Imbalances & Inflammation

Omega 6 Fatty AcidsAnti-Inflammatory Pro-Inflammatory

Eicosanoids

Arachidonic Acid

Phospholipase A2

Cyclooxygenase (COX)

Aspirin

LipoxygenaseA2

Prostaglandin H2

Thromboxanes A2

Prostacyclins (PGI2

Prostaglandins

PGD2

PGE2

PGF2

NSAIDs

Advil

Motrin

Leukotrienes

Mast Cells

SpleenLiver

Heart

Bronchospasm

Histamine

• Structural components of all membranes– Increased fluidity & permeability– Optimal organelle function• Precursors for eicosanoid synthesis– “Local” hormones– Regulate inflammation• Structural components of all membranes– Increased fluidity & permeability– Optimal organelle function• Precursors for eicosanoid synthesis– “Local” hormones– Regulate inflammation

Major roles of EFAs

168

The fluidity and permeability of membranes is largely determined by the degree of unsaturation of the fats in the membrane phospholipids.

Cell Membranes

Injury Agent, Physical or Chemical Injury to Cell

Cell Membrane Damage

Arachidonic Acid, Phopholipase A2EPA

PG2, Cyclooxygenase

TXA 2

Platelet AggregationPDGF

PG3

TXA3

No Platelet Aggregation

Aspirin Binds CoxEPA Competes for Cox

Essential Fatty Acids

Linoleic AcidOils of corn, safflower, sunflower, sesame

Alpha-linolenic Acid

Flax, pumpkin, chia, walnut

GLA Arachidonic Acid

Animal meat, milk

EPA/DHA

PGE2

PGE3

IL-1, Il-6 IL-2, PGE 3, PGE 6

Ratio Omega 6 Fatty Acid to Omega 3 Fatty Acid

1:1 4:1 45:1

Blood Type, Diet and Inflammation

O

A B

AB


• The classification of an individual’s blood type is made possible by the fact that blood cells clump together or agglutinate when exposed to specific substances.

• Substances on the surface of red blood cells give those cells a unique chemical personality and are responsible for the unique pattern of agglutination that results in blood typing. Manufacture of these substances is controlled by the genes.

• These substances that sit on the surface of red blood cells are also found in secretions throughout the body, as well as on the surface of many tissues, such as tissues of the intestinal tract, lungs and liver.

• These substances called antigens, are specific proteins that impart a chemical message to the surface of the tissue or in the biological fluids, creating a unique reaction between antigen and the external world.


Lectins and Inflammation

Lectins, abundant and diverse proteins found in food, have agglutinating properties that affect the blood.

Agglutinating actions of Lectins gum the works.

The connection of food lectins to ABO blood type and disease risk is further amplified when an individual is exposed to potentially infectious bacteria. Bacteria have antigens sitting on their surface, and those antigens can crossreact with either type A or type B blood food lectins. This association indicates; diets that contain lectins that are incompatible with a specific blood type antigen could increase the risk of bacterial adherence to the digestive tract and subsequent infection.


Anti-Oxidents & Inflammation

EnzymaticSOD

Catalase Glutathione Peroxidase

Non-EnzymaticVitamin E Vitamin C Glutathione

Anti-Oxidents

Antioxidents are plant-based agents from food that act like protectors that neutralize free radicals. They do this by pairing an electron to the outermost shell of the free radical oxygen molecules, which make them harmless.

Antioxidents are nutrients like vitamins A, C, E, minerals, and enzymes that can conteract the normal effects of oxidation in body tissues. These along with beta-carotene, luteins, lycopene, and selenim make up the force to rescue healthy cells. By breaking the chain of free radicals or to prevent oxidation.

Free Radicals (ROS)Demonstrate Apple

Free radicals are atoms with an odd (unpaired number of electrons and can be formed when oxygen interacts with certain molecules. Once formed these Highly reactive radicals can start a chain reaction, like dominoes. Their chief danger comes from the damage they can do when they react with important cellular components such as DNA, or the cell membrane. Cells may function poorly or die if this occurs. To prevent free radical damage the body has a defense system of antioxidents

Even though some free radical production is normal, things like stress, smoking, exercise, and aging contribute to the production of harmful free radicals.

No one can avoid free radicals. It is even thought that free radicals play a part in disease processes like cancer.

Free Radicals (ROS)

183

If the organs of your body are not defended by sufficient antioxidants against oxidative stress, they lose function over time, and their ability to produce hormones or control immune function is lost. After several years , free radical-induced organ damage can result in the appearance of “twisted molecules”. These unnatural twisted molecules can activate the body’s immune system to combat misidentified foreign invaders, resulting in damage to organs like the thyroid.

Free Radicals (ROS)

White blood cells specialize in producing free radicals which are used in host defense to kill invading pathogens

Inflammation and Cancer

Cancer

Cancer is a disease process in which normal cells begin to divide uncontrollably and can spread to healthy tissues by a process called metastasis (transfer of disease from one organ to another not directly connected)

2 Types of Cancer

Carcinoma

Sarcoma

What is the Definition of Cancer

Types of CancerCarcinoma: Generally a cancer derived from epithelial tissue that line or cover body organs.

Sarcoma: Generally a cancer of the bone, cartilidge, fat, muscle, blood vessels or other connective tissue.

Cancer is a disease process in which “normal” cells begin to divide uncontrollably and can spread to healthy tissues by a process called metasisis.

Causes of Cancer

Genetic Predisposition

DietToo many calories/Wrong type of caloriesBlood sugar/Insulin ratiosInsufficient nutrients

LifestyleStress Obesity/Lack of Exercise Lack of Quality Sleep

EnvironmentAirFood/WaterSkinToo much exposure to the sun/radiation

Current Cancer Statistics

1 in every 2-3 Americans will develop life-threatening cancer.

The rates of virtually all cancers are increasing with the exception of lung cancer.

In the majority of cases cancer has already spread by the time of initial diagnosis.

In just 1 year, more people in the United States die of cancer than the number of US soldiers killed in WWII, Korea, and Vietnam wars combined

“Statistics are information, not condemnation.”

“American Women’s Health Initiative. This study demonstrated that the link between obesity and breast cancer is dependent on the level of insulin in the blood, and thus the level of sugar in the diet. The study also showed that sugar may be contributing more to cancer than hormone replacement therapy.”

“Genes of biological parents who died of cancer before fifty had no influence on an adoptee’s risk of developing cancer. On the other hand, death from cancer before the age of fifty of an adoptive parent (who passes on habits but not genes) increased the rate of mortality from cancer fivefold among the adoptees. This study shows that the lifestyle is fundamentally involved in vulnerability to cancer…Genetic factors contribute to at most 15 percent of mortalities from cancer.”

“Dean Ornish of the University of California at San Francisco demonstrated that lifestyle changes in diet and exercise and stress reduction actually modified gene expression deep within cancer cells.”


Relative to men in the West, just as many precancerous microtumors are found in the prostates of Asian men who die before fifty from causes other than cancer. Something in their way of life prevents these microtumors from developing” (8).

“In his introduction to the report of the International Agency for Cancer Research, the general director of WHO concluded, “Up to 80% of cancers may be influenced by external factors, such as lifestyle and the environment.” (64)

“Cancer is more widespread today in the West and has been increasing since 1940. Hence, we must examine what has changed in our countries since World War II.

There is good reason to believe that the sugar boom contributes to the cancer epidemic, as it is linked to an explosion of insulin and IGF in our bodies. Mice inoculated with breast cancer cells have been used to compare the effect on tumor growth of different foods of varying glycemic indices. After two and a half months, two thirds (sixteen) of the twenty-four mice whose blood sugar peaked frequently were dead, compared to only one of the twenty that had been on a low-glycemic-index diet.” (68).

“In addition, people with diabetes (characterized by high blood sugar levels) are known to be at above-average risk for cancer.”


Example of egg, small changes make a big difference

Crime in area arrest all criminals or environmental, poverty, poor education

How a Cancer Cell Survives

Low pH (Acidic)

Anaerobic Environment (Low Oxygen)

Apoptosis (Cell Death)

Sugar (Glucose)

Impaired Immune System

Inflammatory Environment

Angiogenisis ( New Blood Vessels)

Cancer lies dormant in all of us.

The Basics of Cancer

Cancer cells really do act like armed bandits, roving outside the law. They are unhindered by any of the restraints a healthy body respects. With their abnormal genes, they escape the mechanisms controlling normal, healthy tissues. For example, they lose the obligation to die after a certain number of divisions. They become immortal. They ignore signals from surrounding tissues – alarmed by the overcrowding – that tell them to stop multiplying. Still worse, they poison these tissues with the particular substances they secrete. These poisons create a local inflammation that stimulates the cancerous expansion even more, at the expense of neighboring territories. Finally, like an army on the march seeking fresh supplies, they requisition nearby blood vessels. They force them to proliferate and furnish the oxygen and nutrients needed for the growth of what will soon become a tumor” (32).

The Basics of Cancer

Initiation – the presence of a potentially dangerous seed – depends largely on our genes and toxins in our environment (radiation, carcinogenic chemicals, etc.).

But the seed’s growth (promotion) depends on the existence of the indispensable conditions for its survival: favorable soil, water, and sun. Promotion is reversible, depending on whether the early cancer growth is given the right conditions in which to grow. This is where dietary factors are so important. These dietary factors, called promoters, feed cancer growth. Other dietary factors, called anti-promoters, slow cancer growth. Cancer flourishes when there are more promoters than anti-promoters. Cancer growth slows or stops when the anti-promoters prevail. Even when the nutritional conditions for maximum promotion are present – as is the case in Western diets – it is thought that fewer than one cancerous cell out of ten thousand manages to become a tumor capable of invading tissues. By acting on the soil in which these cancer seeds are deposited, it is thus possible to considerably reduce their chances of developing.

three stages of tumor growth – initiation, promotion, and progression – growth of weeds. Initiation is the phase when a seed settles in the soil. Promotion is the phase when the seed becomes a plant. Progression is the phase when the plant becomes a weed, developing beyond control, invading flower beds and garden paths, growing right up to the sidewalk.

Cancer Feeds On Sugar “Consumption of refined sugar has skyrocketed. Whereas our genes

developed in an environment where one person consumed at most 2 kilograms (4 pounds) of honey a year, human sugar consumption rose to 5 kilograms (11 pounds) a year in 1830 and a shocking 70 kilograms (150 pounds) a year at the end of the twentieth century.

The German biologist Otto Heinrich Warburg won the Nobel Prize in medicine for his discovery that the metabolism of malignant tumors is largely dependent on glucose consumption. (Glucose is the form of digested sugar in the body.) In fact, the PET scan commonly used to detect cancer simply measures the areas in the body that consume the most glucose. If a particular area stands out because it consumes too much sugar, cancer is very likely the cause.

When we eat sugar or white flour – foods with a high “glycemic index” – blood levels of glucose rise rapidly. The body immediately releases a dose of insulin to enable the glucose to enter cells. The secretion of insulin is accompanied by the release of another molecule, called IGF (insulin like growth factor), whose role is to stimulate cell growth. In short, sugar nourishes tissues and makes them grow faster. Furthermore, insulin and IGF have another effect in common: They promote the factors of inflammation, also stimulate cell growth and act, in turn, as fertilizer for tumors.

Cancer Feeds On SugarToday, we know that the peaks of insulin and the secretion of IGF directly stimulate not

only the growth of cancer cells, but also their capacity to invade neighboring tissues. Moreover, after injecting breast cancer cells into mice, researchers have shown that the cancer cells are less susceptible to chemotherapy when the mouse’s insulin system has been stimulated by the presence of sugar. The researchers concluded that a new class of medications is needed now to fight cancer: medicines that reduce insulin peaks and IGF in the blood.”

“In the second half of the twentieth century, a new ingredient took root and spread like a weed in Western diets: high-fructose syrup extracted from corn (a mix of fructose and glucose). Our bodies already had trouble tolerating the refined sugar we were loading up on. Now they were totally overwhelmed by this sugar syrup ubiquitous in processed foods. Removed from its natural matrix (there is fructose in all fruits) and mixed with glucose, it can no longer be handled by the insulin our bodies produce, at least not without collateral damage. It then becomes toxic.

“The study, published in the Journal of the National Cancer Institute, concludes that it is not only obesity per se that is a risk factor for breast cancer, but rather high insulin levels that tend to be associated with excessive body weight. The women with the higher insulin levels (and who were not diabetic or taking hormone replacement therapy) had almost twice the risk of developing breast cancer during the follow-up period compared to those whose insulin levels were the lowest.”

Cancer Feeds On Sugar

Cancer Feeds On SugarThe Warburg Effect

Otto Warburg observed that cancer cells' metabolism is different than the one of normal adult cells. Normal adult cells use a small energy plant located inside them to produce most of their energy needs from oxygen, this is an aerobic process. In contrast, cancer cells rely mainly on the first part of the energy production process dependant on glucose (sugar), this is an anaerobic process. The anaerobic process is called

glycolysis.

The paradox is that cancer cells rely on glycolysis even if oxygen is available. This phenomenon is called aerobic glycolysis or the Warburg effect.

Glycolytic Metabolism

Glycolysis

Kreb Cycle 36 ATP

Normal Cellular Metabolism; Aerobic Glycolysis

Abnormal Cellular Metabolism; Anaerobic Glycolysis

2 ATP Lactic Acid

Increased acidic pH, Fatigue, Undernourished

Inflammation and Cancer“As soon as a lesion – from shock, cutting, burning, poison, infection – affects a tissue, it

is detected by blood platelets. As they gather around the damaged segment, they release a chemical substance – PDGF, or platelet-derived growth factor. PDGF alerts the white cells of the immune system. The white cells in turn produce a series of other transmitter substances. They have odd names and many effects. These cytokines, chemokines, prostaglandins, leukotrienes, and thromboxanes coordinate the repair operations. First, they dilate the vessels surrounding the damaged site to facilitate the influx of other immune cells called in as reinforcements. Next, they seal off the opening by provoking the coagulation of blood around the built-up pile of platelets. Then they render the neighboring tissue permeable so that the immune cells can enter and pursue the intruders wherever they may be. Finally, they trigger growth of the damaged tissue’s cells. The tissue can then regenerate the missing piece and grow small blood vessels locally to deliver oxygen and food to the construction site.”

“Growth of new tissue stops as soon as the essential replacements have been carried out. The immune cells activated to deal with intruders return to their watchful, standby mode. This is an essential step to prevent the immune cells from continuing on and attacking healthy tissue.”

Inflammation and Cancer“National Cancer Institute brought out a report highlighting inflammation research too

often ignored by oncologists. The report describes in great detail the processes by which cancer cells manage to lead the body’s healing mechanisms astray. Just like immune cells gearing up to repair lesions, cancer cells need to produce inflammation to sustain their growth.

“In the case of normally healing lesions, the production of inflammatory chemical substances stops when the tissue is restored. In the case of cancer, proliferation of these substances occurs continuously. In turn, surplus inflammatory chemicals in neighboring tissues block a natural process called apoptosis – the suicide of cells. Apoptosis is genetically programmed into every cell to prevent anarchy due to overproduction of tissues. Cells naturally enter apoptosis in response to signals indicating that enough cells have been created to form healthy tissue. Thus, at the same time that they stimulate their own growth, cancer cells are also protected from death. It is the combination of these factors that causes the tumor to gradually expand.”

By adding fuel to the fire of inflammation, tumors create yet another disruption. They “disarm” the immune cells in the vicinity. In simple terms, the overproduction of inflammatory factors throws neighboring white blood cells into disarray. The natural killer cells and other white blood cells are neutralized. They don’t even try to fight the tumor, which prospers and grows in plain sight

Inflammation and CancerBy encouraging immune cells to produce inflammation, the tumor gets the body to make

the fuel needed for its own growth and invasion of surrounding tissues. The larger the tumor, the more inflammation it causes and the better it sustains its own growth

If the tumor’s environment is deprived of the inflammatory factors needed for its growth, it will not succeed in spreading. The fact is that these inflammatory factors, these fertilizers for cancer, are provided directly by our diet. Major dietary fertilizers are refined sugars, which drive up proinflammatory insulin and IGF; insufficient amounts of omega-3s and the corresponding excess of omega-6s, which change into inflammatory molecules; and growth hormones (present in meat and nonorganic dairy products), which also stimulate IGF. Conversely, diet may also furnish “antipromoters,” such as all the phytochemical components of some vegetables or particular fruits, which directly counterbalance inflammatory mechanisms.

(From Nature, by researchers at the Cancer Research Institute of the University of California at San Francisco)

Inflammation and CancerNatural killer (NK) cells are very special agents of the immune system. Like all white blood cells, they patrol the organism continually in search of bacteria, viruses, or new cancer cells. But while other cells of the immune system need previous exposure to disease agents in order to recognize and combat them, NK cells don’t need prior introduction to an antigen in order to mobilize. As soon as they detect an enemy, they gather around the intruders, seeking membrane to membrane contact. Once they make contact, NK cells aim their internal equipment at their target, like a tank turret. This equipment carries vesicles filled with poisons. On contact with the cancer cell’s surface, the vesicles are released and the chemical weapons of the NK cells – perforin and granzymes – penetrate the membrane

At the core of the cancer cell, the granzymes then activate the mechanisms of programmed self-destruction. It’s as if they give the cancer cell an order to commit suicide, an order it has no choice but to obey. In response to this message, its nucleus crumbles, leading to he cancer cell’s collapse. The deflated remains of the cell are then ready to be digested by macrophages, which are the garbage collectors of the immune system and are always found in the wake of NK cells.” (36)

Inflammation and CancerHuman NK cells are capable of killing different types of cancer cells, in

particular sarcoma cells as well as those of breast, prostat“The less active the NK and other white blood cells were under the microscope, the more rapid the cancer’s progress and the more it spread throughout the body in the form of metastases“Cancer cells will flourish only within an individual whose immune defenses have been weakened. It may be primarily the lack of healthy defenses that allows otherwise dormant cancer cells to become aggressive tumors.e, lung, or colon cancer.

immune cells (including NK cells and white blood cells targeted against cancer) show that they are at their best when our diets are healthy, our environment is “clean”, and our physical activity involves the entire body (not just our brains and our hands). Immu“Rubor, tumor, calor, dolor. It’s red, it’s swollen, it’s warm, and it’s painful. Beneath these simple outward signs, complex and powerful operations go on.” (41).

ne cells are also sensitive to our emotions.

Inflammation and Cancer

Picture of Inflammation and Cancer

Angiogenisis and CancerCancer cells must have nourishment imported and waste exported. To survive,

tumors thus need to be deeply infiltrated with capillaries. But since tumors grow at high speed, new blood vessels must be made to sprout quickly

Blood vessels are typically a stable infrastructure. Their wall cells don’t multiply and, except in particular circumstances, they don’t create new capillaries. New blood vessels grow when there is a need to repair wounds and after menstruation. This mechanism of “normal” angiogenesis is self-limiting and firmly controlled. Limits naturally placed on it prevent the creation of fragile vessels that would bleed too easily. In order to grow, cancer cells hijack the body’s capacity to create new vessels for their own use

Microtumors cannot change into dangerous cancers without creating a new network of blood vessels to feed them

To do so, they produce a chemical substance called angiogenin that forces the vessels to approach them and to sprout new branches.

The new tumor cells that spread to the rest of the body – metastases – are dangerous only when they are able, in turn, to attract new blood vessels.

Angiogenisis and Cancer

Angiogenisis and CancerLarge primary tumors send out metastases. But as in any colonial empire, they prevent

these distant territories from becoming too important by producing another chemical substance that blocks the growth of new blood vessels – angiostatin. (This explains why metastases sometimes suddenly grow once the principal tumor has been surgically removed.)

In addition, it was shown that angiostatin attacked fast-growing blood vessels and didn’t affect existing vessels in the least. Nor did it attack the body’s healthy cells, in contrast to traditional cancer treatments such as chemotherapy and radiotherapy

Physical Measurements of Aging • Muscle Mass/Strength

• Basal Metabolic Rate

• Fat Percentage

• Aerobic Capacity

• Blood Pressure

• Bone Density

• Temperature Regulation

• One-Minute Sit-ups

• One-Minute Pushups

• Low Back Flexibility

• Shoulder Flexibility

• Waist to Hip Ratio

• Body Mass Index

Physical Measurements Laboratory• Blood Sugar/Insulin

• Cholesterol/HDL Ratio ++

• Homocysteine

• Hs-C-Reactive Protein

• Estrogen/Testosterone

• DHEA

• TSH/T3/T4/Reverse T3

• Intrinsic Growth Factor

• pH Blood/Urine

• Cortisol/24hour

• Fibrinogen

• CBC w/ Diff Liver Profile

• LDL/VLDL

Daily Anti-Inflammatory Supplement Recommendations (REQUIRED)

Vitamin A (beta carotene) 1,000-5,000 IU

B2 Riboflavin 25-100 mg

Vitamin A (retinol) 500-1,000 IU

B1 Thiamine 25-100 mg

B3 Niacin 50-100mg

B6 Pyridoxine 50-100 mg

B12 Cyanocobalamin 100-500 mcg

Vitamin C (ascorbic acid) 1,000-3,000 mg

Vitamin D 400-800 IU

Vitamin E (mixed tocopheryls) 1,000-2,000 IU

Vitamin K 100-150 mcgBioflavonoids 1000-2000 mg

Lutein 8-12 mgLycopene 5-10 mgBiotin 200-300 mcgFolate 5 Methyl tetrahydrofolate 1000mcg DIET

B5 Pantothenic Acid 50-100 mg

Boron 3-6 mg

PABA 25-50 mgCholine 50-100 mg

Calcium 1,000-1,500 mg

Chromium 200 mcg

Copper 2-3 mg

Iron 10-15 mg

Magnesium 500-750 mg

Manganese 5 mg

Potassium 100-300 mg

Zinc 10-25 mg

Inositol 25-100 mg

Selenium 100-200 mcg

Vanadium 30 mcg

Molybdenum 30 mcg

Iodide 150 mcg

DIET

Silica 250-500 mg

Daily Anti-Inflammatory Supplement Recommendations (REQUIRED)

Alpha Lipoic Acid 500mg

Co-Enzyme Q 10 100 mg

DHEA 25-50 mg

N-Acetylcysteine 500 mg

Quercetin 50 mg

L-Carnitine 500 mg

Indole-3-Carbinol 300 mg

Silymarin Milk Thistle 200 mg

Garlic (allium) 500 mg

Daily Anti-Inflammatory Supplement Recommendations (SUGGESTED)

DIET

Digestive Enzymes

Essential Fatty Acids

EPA 300mg

DHA 400mg

NPA Natural Products AssociationNSF National Sanitation FoundationTGA Therapeutic Goods AssociationGMP Good Manufacturing Practices

Aspirin 80 mg

Conjugated Linoleic Acid 500mg

Epigallocatechin gallate (EGCG)

Reservatrol 50 mg

Aloe Vera

Cat’s Claw 200 mg

Panax Ginsng 150 mg

Astragalus (membranaceus) 150 mg

Echinacea (purpurea 80 mg

Daily Anti-Inflammatory Supplements Recommendations (SUGGESTED)

DIET

Mushroom (Maitake, Shiitake)

Curcumin 1,000 mg

Melatonin 2 grams

Epigallocatechin gallate (EGCG)

Reservatrol 50 mg

Aloe Vera

Cat’s Claw 200 mg

Panax Ginsng 150 mg

Astragalus (membranaceus) 150 mg

Echinacea (purpurea 80 mg

Anti-Angiogenisis

DIET

Mushroom (Maitake, Shiitake)

Curcumin 1,000 mg

Melatonin 2 grams

European Mistletoe

Chinese Skullcap

Chinese Wormwood

Milk Thistle

Green Tea

Quercetin 50 mg

pH of FoodsAcid-Alkaline Forming Foods

Acid/Alkaline (pH) are the two characteristic conditions of blood and cell solution. Any solution is either more acid or more alkaline. If acidic characteristics dominate, the solution is acid. However, there is no absolute acid or alkaline.An acid solution always contains some alkaline factors, and an alkaline solutionalways contains some acid factors. Neutrality is an ideal condition in which the amount of acid and alkalinity is equal. It is an ideal state, and not realistic. In reality, what we eat or drink is always more acid or alkaline.ACIDOSIS is not in itself a specific disease; it is a general condition of the blood and is thus the root of many different diseases such as diabetes, high blood pressure, arthritis, cancer, tumors and many more.Many people today have this blood condition without knowing about it. ALKALOSIS is not as common as acidosis but indicates an unbalanced blood condition.All natural foods contain both acid and alkaline forming elements. In some, acid forming elements dominate; in others, alkaline forming elements dominate. According to modern biochemistry, it is not the organic matter of foods that leave acid or alkaline residues in the body. The inorganic matter (sulphur, phosphorus, potassium, sodium, magnesium and calcium) determines the acidity or alkalinity of the body luids. Food comparatively rich in acid forming elements are acid forming foods; those comparatively rich in alkaline forming elements are alkaline forming foods.Acidic condition inhibits nerve action, alkalinity stimulates nerve action. One who has a balanced condition can think and act (decide) well.

pH of Foods

A balanced food plan is a great help in maintaining the pH balance of the blood; however it does not reveal results in a day or two. It takes a longer time to show the effect. Cold showers make the blood alkaline, while hot showers make the blood acid. If the blood develops a more acidic condition, then our body inevitably deposits these excess acidic substances in some area of the body such so that the blood will be able to maintain an alkaline condition. As this tendency continues, such areas increase in acidity and some cells die; then these dead cells themselves turn into acids. However, some other cells may adapt in that environment. In other words, instead of dying as normal cells do in a acid environment some cells survive by becoming abnormal cells. These abnormalcells are called malignant cells. Malignant cells do not correspond with brain function nor with our own DNA memory code. Therefore, malignant cells grow indefinitely and without order. This is cancer, and cancer develops in the following stages:1. Ingestion of many acid forming foods, fatty foods, refined foods, carcinogenic substances such as nitrates, and chemically treated foods in general. X-ray scans contribute even at this stage.2. Increased constipation.3. Increase of acidity in the blood. This causes an increase of white cells and a decrease of red cells, which is the beginning of leukemia.4. Increase of acidity in the extracellular fluids.

Acid-Alkaline Forming Foods Cont.

pH of Foods

DIET

Foods may be classified in relation to the metabolic process as acid alkaline. Alkalies are soluble salts and acids are corrosive agents which have trouble combining with other things. A balanced diet contains 20% acid forming foods and 80% alkaline.

HIGHLY ALKALINE-Beans string-Banana speckled-Dandelion greens-Dates-Figs/ Prune-Raisins-Swiss chard

HIGH ALKALINE-Almonds-Avocado-Banana yellow-Bean fresh-Beet-Blackberries-Carrot-Chives-Cranberries-Endive-Grapes sour-Kale-Peach dried-Persimmon-Pomegranate-Plum-Raspberries-Spinach

NEUTRAL OILS-cold pressed-expeller pressed-Almond-Avocado-Coconut-Canola-Cottonseed-Linseed-Olive-Safflower-Sesame-Soy-Sunflower-Walnut

pH of Foods

DIET

ALKALINE-Agar-Alfalfa-Apple & fresh-Apple cider-Apricot fresh-Artichokes globe-Bamboo shoots-Bean snap-Beans sprouted-Berries most-Blueberries-Broccoli-Brussels sprouts-Cabbage-Cantaloupe-Cauliflower-Celery-Cherries-Chestnuts-Chicory

ALKALINE-Coconut milk& fresh meat-Collards-Corn fresh& sweet-Cucumbers-Daikon-Eggplant-Escarole-Garlic-Ginger root-Gooseberry-Grapefruit-Guave-Horseradishfresh & raw-Kelp-Kohlrabi-Leek-Lemon & peel

ALKALINE-Lettuce-Lime-Loganberry-Mango-Melons-Milk raw, alsoacidophilus-yogurt & whey-Mushrooms-Nectarines-Okra-Onion-Oranges-Parsnips-Peach fresh-Pear fresh-Peas, sprouted-Peppers, red& green-Pineapple ripe

ALKALINE-Potatoes yellow,red, white, sweet& blue-Prickly pear-Pumpkin-Quince-Radishes-Rhubarb-Rutabaga-Sauerkrautwith lemon-Soybeans-Squash, summer-Tamari-Tangerine-Teas herbal-Tofu-Tomato-Turnip-Watercress-Watermelon-Yeast

pH of Foods

DIET

ACID-Mutton-Peas, dry-Pecans-Plums damson-Pork-Poultry-Tofu fried-Waterchestnuts

ACID FATS-Butter-Cream-Margarine-Animal fat-Lard

HIGHLY ACID-Alcohol-Artichoke root-Barley-Bread-Buckwheat-Caffeine-Coffee-Corn,dry& products-Custards-Drugs-Flour all-Gingerpreserved-Honey-Lentil dry-Mate-Millet-Oatmeal-Peanuts

HIGHLY ACID-Rice all-Rye grain-Soy bread-Soy noodles-Sorghum,grain-Squash, winter-Spaghetti &other pasta-Sugar-cane,raw, beet-Tobacco-Walnut, english-Wheat grain

ACID-Asparagus-Beans dried-Beef-Cashews-Coconut dried-Cranberry juice& concentrate-Egg yolk-Filbert--Fish all salt& fresh water-Fruit jellies-jams cannedsulphured,sugared & dried-Gelatin-Goat meat-Grapes sweet-Milk products& pasteurized

Anti-Inflammatory

DIET

• Water (pure) with Lemon 60 oz/Daily

• Diet

• 40 % Carbohydrates

• 60% Complex Carbohydrates

• 20% Fiber

• 20 % Sugar (Low Glycemic Index)

• 30% Protein

• Consider Protein Powder Drink with Full Compliment of Amino Acids

• 30% Fat

• 80% Unsaturated Fatty Acids

• 20% Saturated Fatty Acids

• High Alkaline Foods

• Juicing?

• Lower Daily Caloric Intake

DIET• Eat Organic Foods/Wash Fruits and Vegetables

Daily Healthy-Aging Diet Recommendations (SUGGESTED)

Daily Healthy-Aging Diet Recommendations

• Reduce Intake Of Soft Drinks/Refined Sugars

• Minimize use of Artificial Sweeteners

DIET

• Eat High Quality Breakfast ½ Hour after Awakening

• Eat 6 Small Meals/Day

Foods High in ORAC Scale (Oxygen Radical Absorbance Capacity) 3,000/Daily• Wolfberry 25,300 (3.5 oz)

• Blueberries 2,400 (3.5 oz)

• Garlic 1,939 (3.5 oz)

• Spinach 1,260 (3.5 oz)

• Thyme Oil 159,590 (3.5 oz)

• Fiber Soluble 20g

• Fiber Insoluble 10g

• Eliminate Allergy Potential Foods

Daily Healthy-Aging Daily Activities Recommendations

• Exercise

• 30 Minutes 5X/Week Aerobic @ heart rate between 80-120

• The ability of a cell to produce ATP (energy) from fat or carbohydrates due to an unlimited supply of oxygen

• O2 + Carbohydrates/Fat = ATP (energy)

• 30 Minutes 3X/Week of Strength Training 70%/1rep

• Lack of oxygen prevents the cell from utilizing

fat as an energy source. The cell ineffecectively

burns carbohydrate. Pyruvate is blocked and lactic

acid is produced.

• Carbohydrate – O2 = Decreased ATP and lactate

Lifestyle

• In the absence of O2,fat, Sugar the cell can produce a very fast energy source. The amount of energy produced is very limited and only lasts for seconds

Daily Healthy-Aging Daily Activities Recommendations

• Stretch 15 Minutes/Daily• Stress Holmes-Rahe Stress Rating Scale

• Deep Breathing Techniques

• Meditation

• Listen to De-Stressing CD’s

• Use Aromatherapy

• Think Positive Thoughts

• Laugh

• Infrared Sauna 30 Minutes/3X/Week

• Sea Salt Baths

• 8 Good Hours of Sleep/Night

• Proper Dental Hygiene

• Colonics

Lifestyle

STOP SMOKING

• Life Event Mean Value

• 1. Death of spouse 100• 2. Divorce 73• 3. Marital Separation from mate 65• 4. Detention in jail or other institution 63• 5. Death of a close family member 63• 6. Major personal injury or illness 53• 7. Marriage 50• 8. Being fired at work 47• 9. Marital reconciliation with mate 45• 10. Retirement from work 45• 11. Major change in the health or behavior of a family member 44• 12. Pregnancy 40• 13. Sexual Difficulties 39• 14. Gaining a new family member (i.e.. birth, adoption, older adult moving in, etc) 39• 15. Major business readjustment 39• 16. Major change in financial state (i.e.. a lot worse or better off than usual) 38• 17. Death of a close friend 37• 18. Changing to a different line of work 36• 19. Major change in the number of arguments w/spouse 35• 20. Taking on a mortgage (for home, business, etc..) 31• 21. Foreclosure on a mortgage or loan 30• 22. Major change in responsibilities at work (i.e. promotion, demotion, etc.) 29• 23. Son or daughter leaving home (marriage, attending college, joined mil.) 29• 24. In-law troubles 29• 25. Outstanding personal achievement 28• 26. Spouse beginning or ceasing work outside the home 26• 27. Beginning or ceasing formal schooling 26• 28. Major change in living condition (new home, remodeling, deterioration of neighborhood or home etc.) 25• 29. Revision of personal habits (dress manners, associations, quitting smoking) 24• 30. Troubles with the boss 23• 31. Major changes in working hours or conditions 20• 32. Changes in residence 20• 33. Changing to a new school 20• 34. Major change in usual type and/or amount of recreation 19• 35. Major change in church activity (i.e.. a lot more or less than usual) 19• 36. Major change in social activities (clubs, movies,visiting, etc.) 18• 37. Taking on a loan (car, tv,freezer,etc) 17• 38. Major change in sleeping habits (a lot more or a lot less than usual) 16• 39. Major change in number of family get-togethers ("") 15• 40. Major change in eating habits (a lot more or less food intake, or very different meal hours or surroundings) 15• 41. Vacation 13• 42. Major holidays 12• 43. Minor violations of the law (traffic tickets, jaywalking, disturbing the peace, etc) 11

The Holmes-Rahe Life Stress Inventory

Lifestyle

Daily Healthy-Aging Environmental Recommendations

• Natural/Organic Cleaning Agents

• Water Purifier (Drinking and Shower)

• Open Windows Often

• Hang Dry Cleaning in Garage/3 Days

Environmental

• Remove Carpets

• Add Healthy Live Plants to Your Home

• Get a Good Air Purifier for Your Home

• Hepa Filter with UV

• Remove Mercury Fillings

Daily Healthy-Aging Environmental Recommendations

Environmental

• Check all Bedding for Toxins

• Mattress

• Sheets/Pillows

• Check Air Quality of Indoors

• Decrease Use of Microwave Oven

• Read Labels of ALL Products brought into the House

• Think About ALL Cleaning Supplies/Dry Cleaning

• Purchase Air Filters… Ionic

• Check Household for Mold, Fungus, Bacteria, Etc.

• Think About Carpets, Drapes, Furniture, Etc.

Diet and Cancer Green Tea Blocks Tissue Invasion and Angiogenesis

Green tea, for example, which grows in particularly humid climates, contains numerous polyphenols called catechins. One of these, epigallocatechin gallate or EGCG, is one of the most powerful nutritional molecules against the formation of new blood vessels by cancerous cells. It is destroyed during the fermentation required to make black tea but is found in large quantities in tea that hasn’t undergone fermentation and thus remains “green.” It spreads throughout the body by means of capillary vessels…EGCG settles on the surface of each cell and blocks the switches (the “receptors”) whose function is to set off the signal that allows the penetration of neighboring tissue by foreign cells, such as cancer cells. EGCG is also capable of blocking receptors that issue commands for the creation of new vessels. Once the receptors are blocked by EGCG molecules, they no longer respond to the orders that cancer cells send through inflammation factors to invade tissue and to make the new vessels needed for tumor growth.

EGCG substantially slowed the growth of leukemia and breast, prostate, kidney, skin, and mouth

cancer. Green tea also acts as a detoxifier for the body. It activates mechanisms in the liver that can then

eliminate cancerous toxins from the body more rapidly. In mice, it has been shown to block the effects of chemical carcinogens responsible for breast, lung, esophageal, stomach, and colon cancer.

(EGCG combined with soy, from Laboratory of Nutrition and Metabolism at Harvard)When taken together, the combination of green tea and soy enhances the protective effects observed when each is taken separately. This is true for both prostate and breast cancer.“Our study suggests that soy phytochemicals plus green tea may be used as a potentially effective dietary regimen for inhibiting progression of estrogen dependent breast cancer.”

Diet and Cancer Soy Blocks Dangerous Hormones

Soy, too, contains powerful phytochemical molecules that counteract the mechanisms essential to the survival and spread of cancer. There are the soy isoflavones – especially genistein, daidzein, and glycitein. They are called phytoestrogens because they are very similar to female estrogens.

Soy phytoestrogens are only one hundredth as biologically active as natural female estrogens. They act along the same lines as tamoxifen – a drug commonly used to prevent relapses in breast cancer. Their presence in the blood substantially lowers overstimulation of the body by estrogens and, as a consequence, may slow the growth of estrogen-dependent tumors. However, the protective action of soy against breast cancer has been formally demonstrated only for women who have consumed it since adolescence.

As one of the soy isoflavones, genistein, closely resembles male hormones that stimulate the growth of prostate cancers, the same protective mechanism is likewise at work in men who consume soy regularly.

Moreover, like EGCG in green tea, soy isoflavones also block angiogenesis. They thus plan an

important role in fighting a number of other cancers besides breast and prostate cancer. Different forms of soy (tofu, tempeh, miso, edamame, etc.) are therefore likely to be a useful part of an anticancer diet.

Diet and Cancer Is Olive Oil the Green Tea of the Mediterranean Diet?

Epidemiological studies have shown that people who follow a Mediterranean diet are, on average, far less affected by degenerative illness, cardiac disease, and cancer, despite the significant presence of fats in their diet.

A study directed by Dr. Robert Owen of the German Cancer Research Center in Heidelberg has

demonstrated that olives contain an abundance of antioxidants such as acteosides, hydroxytyrosol, tyrosol, and phenypropionic acids. The direct effect of such molecules is to limit the initial development of cancer.

Particularly when it is virgin, olive oil also contains secoiridoids and lignans, both known as antioxidants that have been linked with slower progression of cancer.

Since all these chemicals are fat soluble, they are absorbed into fatty tissues, with a resulting known protective effect against breast cancer, colon cancer, and uterine cancer.

Diet and CancerTurmeric Is a Powerful Anti-inflammatory

Indians consume on average 1.5 to 2 grams (1/4 to ½ teaspoon) a day of turmeric. The turmeric root yields a yellow powder that is the principal spice in yellow curry. It is also one of the most common ingredients used in ayurvedic medicine for its anti-inflammatory properties. No other food ingredient has such a powerful anti-inflammatory effect. The principal molecule responsible for that effect is curcumin. In the laboratory, curcumin inhibits growth in a large number of cancers: colon, prostate, lung, liver, stomach, breast, ovarian, brain, and leukemia. It also inhibits angiogenesis and forces cancer cells to diet (through the process of cell suicide known as apoptosis).

Indians have one eighth as many lung cancers as Westerners of the same age, one ninth as many colon cancers, one fifth as many breast cancers, one tenth as many kidney cancers, and one fiftieth our rate of prostate cancer. This is true despite Indians’ exposure to numerous carcinogens in their environment, often on a worse scale than in the West.

Diet and Cancer The discovery that the role of inflammatory factors in the development of

tumors, through the activation of the notorious NF-kappa B. Later he wrote that controlling the harmful effects of NF-kappa B in cancer is a “question of life or death.” (M.D. Anderson Cancer Center in Houston, Professor Bharat Bhushan Aggarwal, PhD)

According to the Aggarwal team in Houston, turmeric’s extraordinary effect

seems to be due in large part to its capacity to interfere directly with the NF-kappa B, which protects cancer cells against the body’s defense mechanisms…It is now known that curcumin is a powerful NF-kappa B antagonist…Turmeric can also be eaten with soy products that replace animal proteins and provide the genistein mentioned above, which detoxifies and helps check angiogenesis. Add a cup of green tea and imagine the powerful cocktail that, with no side effects, keeps in check three of the principal mechanisms of cancer growth.

Diet and Cancer

Spice Phytochemical(s) Potential Health Benefits

Allspice Eugenol Antimicrobial, Antioxident, Anti-Inflammatory

Black Pepper Piperine Antioxident, Antimicrobial, Promotes Digestion

Cumin Thymoquinone Antioxident, Anti-Inflammatory

Cinnamon Cinnamaldehyde Antimicrobial, Anti-Inflammatory,

Saffron Alpha-Crocin Antioxident, Antidepressant

Turmeric Curcumin Antioxident, Anti-Inflammatory

Red Chili Capsaicin Anti-Inflammatory, PainRreliever

Garlic Allicin, Allinin, Allyl Antioxident, Antimicrobial

Ginger Gingerol, Shogaols Antioxident, Anti-Inflammatory

Spices of Cancer Prevention

Diet and CancerMushrooms That Stimulate the Immune System

Shiitake, maitake, kawaratake, and enokitake mushrooms are staple foods in Japan. They are now found in hospitals, where they are provided to patients during chemotherapy treatments. These mushrooms contain a molecule called lentinian and this, along with other polysaccharides they contain in great quantities, stimulates the immune system directly.

Plums, Peaches, and Nectarines: It’s Time for Stone Fruit

Berries have recently found some competition: peaches, plums, nectarines, etc. (collectively known as stone fruit), whose anticancer virtues were previously unknown. According to a group of researchers in Texas who reviewed more than a hundred species, these fruits – particularly plums – are at least as rich in anticancer elements as small berries. In this time of economic recession, it’s good to know that a single plum contains as many antioxidants as a handful of berries and costs far less.

Berries: Blackberries, Raspberries, Strawberries, Blueberries…

Antiangiogenic potential of an extract of a raspberry. Ellagic acid is a polyphenol found in large quantities in raspberries and strawberries (it is also found in hazelnuts and walnuts). In doses amounting to a normal dietary portion of raspberries and strawberries, ellagic acid had already shown it could slow tumor growth significantly in mice exposed to aggressive carcinogens.

Ellagic acid in raspberries is potentially just as effective as a medication proven

to slow the growth of blood vessels. Indeed, ellagic acid was shown to act against the two most common mechanisms of stimulation of blood vessels (vascular endothelial growth factors, or VEGF, and platelet-derived growth factor, or PDGF).

Diet and Cancer

Unlike classic antiangiogenic drugs, their action is not confined to this single

mechanism. Ellagic acid also detoxifies cells: It blocks the transformation of environmental carcinogens into toxic substances and stimulates the elimination of toxins. The toxins we are referring to here are dangerous because they interact with DNA and provoke potentially life-threatening genetic mutations.

Another natural anticancer food is cherries, which contain glucaric acid, a

substance that can detoxify the body by facilitating elimination of the xenoestrogens that come from environmental chemicals. Blueberries contain anthocyanidins and proanthocyanidins, molecules that are capable of forcing cancer cells to commit suicide (apoptosis). Other rich sources of proanthocyanidins are cranberries, cinnamon, and dark chocolate.

Diet and Cancer

Diet and Cancer

Spices and Herbs Acting on the Same Mechanisms as Medications

Gleevec blocks the cellular mechanisms that day after day enable the cancer to grow. It acts on one of the genes that stimulate cancer growth, but it is now thought that another key function may be to block one of the switches that stimulate the creation of new blood vessels (the PDGF receptor).

It so happens that many herbs and spices act along some of the same lines as

Gleevec. This is true of the labiate family, for example, which includes mint, thyme, marjoram, oregano, basil, and rosemary. They are rich in fatty acids of the terpene family, which makes them particularly fragrant. Terpenes have been shown to act on a wide variety of tumors by reducing the spread of cancer cells or by provoking their death.

Diet and Cancer

One of these terpenes – carnosol in rosemary – affects the capacity of cancer cells to invade neighboring tissues. Researchers at the National Cancer Institute have demonstrated that rosemary extracts help chemotherapy penetrate cancer cells. In tissue cultures, they lower the resistance of breast cancer cells to chemotherapy.

In Richard Beliveau’s experiments, apigenine – plentiful in parsley and celery – has demonstrated powerful inhibition of the creation of blood vessels, which tumors need to grow, and to a degree comparable to Gleevec.

Questionnaires

Assessments

Examination

Laboratory Analysis

• BloodUrineSalivaStoolHair

Risk Factors

Indicators of a Disease process

OrIf a disease may havethe tools to develop

Fittness A ssessment

0

33.3

66.6

99.9

H igh

M edium

Low

0

33.3

66.6

99.9gastrointestinal

liver/gallbladder

endocrin

e

glucose

cardiovascular

mood

immune

urological

musculoskeletal

cns & brain

male

Phases of Treatment

Elimination Diet Detoxification

Calorie Restriction

Diet/Nutraceaticals

Phase

I

Phase

II

Phase

III

OPTIMAL FUNCTIONAL HEALTH

Low Glycemic

Digestion/Absorption

Detoxification/Elimination

Endocrine Imbalances

Immune/Inflammatory Imbalance

Lifestyle

Reintroduction

Environment

Record PageOne-Mile Walk Time __________

Pulse Rate __________

One-Minute Sit-Up # of sit-ups __________

One-Minute Push-Ups(# of push-ups) __________

Sit and Reach Length of Stretch __________

Shoulder Flexibility Right hand over (R) shoulder __________Left hand over (L) shoulder __________

Body Composition Percent body fat __________ Pounds of fat __________

Blood Pressure Systolic (upper) __________

Diastolic (lower) __________Waist to Hip Ratio Waist____/ Hip_____ __________

Body Mass Index Weight____/Height ____ __________

Stress Evaluation 330+At risk of illness, 150-299+: Risk of illness is moderate (reduced by 30% from the above risk), 150-: Only have a slight risk of illness. __________

• There are several aspects of any program that are important to success. It doesn’t matter what the program is: making money, self esteem, or being successful. No matter what the program is and all the factors that come into play, there is one part of every program that is crucial if you are to succeed. Attitude, attitude, attitude! What you believe about yourself is the single most important factor in determining your success. I have been practicing for over 15 years now and I can usually tell if a person will succeed with me on the first visit. People who sit in front of me and question themselves are more likely to struggle with the program. They are not just questioning their abilities entering my program; they are actually questioning everything about themselves. If you don’t have the belief in yourself, chances are you will struggle with most things in your life. You must believe that you can accomplish anything you want. You have to understand that you set up success or failure with your words, beliefs, and attitude. The vision you set for yourself will determine your success. If you see yourself as a failure, you will be one. If you see yourself as 2nd best, you will be 3rd, 4th, 5th or last. If you see yourself as not good enough, you won’t be. Your vision of how you see yourself is crucial for success. The vision that you have of yourself has to be positive. You must enlarge your vision of yourself to see you as successful, #1, able to accomplish whatever you want. Your vision must start now if you are to change old behavior that has led you to failure in the past. The past is the past. Let it go and concentrate on your new vision of yourself. See yourself as successful with this program. Believe that you can succeed with this new health challenge. See yourself completing each phase and feeling better after each one. How you see yourself will set the tone for your program. Believe in you and you will see in you the success that you deserve. Others around you will also see the changes which will motivate you even more to be successful. If I didn’t believe in myself and my program you would not be reading this now. I never would have had the confidence to put thousands of hours into developing this effective program. I saw myself succeeding and ultimately it worked. Changes will not happen over night. It will take time to see changes in your health and in your vision of yourself. Be patient. It will happen. Time is on your side. Let it flow over your vision and eventually it will begin to change how you see yourself. Just remember, how you perceive yourself will affect your success. Change your vision, change your life. It will work.

Attitude

Self Image• Another important aspect of achieving success with my program is your self image. So many of my patients I

believe feel they are not worth feeling better. They feel for some reason their sickness is justification for injustices they have committed. Some of my patients plainly just don’t want to get better because they feel they don’t deserve to. Working with people who have this attitude is extremely difficult. How can I help somebody who feels they don’t deserve to get better and who subconsciously don’t want to? Why are they in my office? Why do they desire to start this program? Many people don’t realize that they are unconsciously punishing themselves. Some people are actually happier with their pain and illnesses because at some level they feel it is right and it is the only identity they have. Unfortunately, some of my patients just want to feel sorry for themselves and enjoy the attention they receive from their illness. Whatever the reason they commit these behavioral suicide mentalities, they need to realize that if they do not change, they are destined to be a victim the rest of their lives. If this is a part of your behavior, you must realize the direct effect these behaviors have on your success. You must begin to accept the fact that you are worth every effort that you and people around you put into you. You deserve a vibrant, healthy, and happy life. You were created to prosper and be healthy. What happened along the way for you to feel otherwise must be addressed. Positive self image is so important if you are going to succeed. Believe in yourself and you will receive all the benefits that you are meant to have. Believe in you and you begin to change not only your outward appearance but your internal physiology as well. Believe that you yourself will succeed and that you deserve to succeed and your body chemistry will begin to change. Enzymes, hormones, inflammatory chemicals will begin to lessen and your body will begin to heal. Healing begins from the inside out. Your body has an amazing quality to heal itself given the proper tools. Let yourself be blessed with the healing grace that we all possess within us. Believe that you are worth healing and you will succeed. You are worth the best possible healthy state you can achieve. Despite all that you have done, or all that may have happened to you, BELIEVE! You are worth it. What you believe has a much greater impact on your health than what others may believe about you. Don’t worry about what others may think. What is important is what you believe about yourself and what you believe must be positive. Don’t get caught up with how others perceive you. “Believe and You Will Receive”. Healing is far more than drugs or what you put into your body. True healing starts from within, from your mind. Learn to train your mind that you are healthy and worth it. Your mind has a direct connection to your body and soul. You must learn to think positive thoughts about you and your health. Thinking is believing. Positive self image and the true belief that you are worth all things good and healthy is part of this program. Everyday, every hour you must believe that you will succeed and you are worth it. If someone around you is being critical of you and attempting to sabotage your program you must learn to ignore their negative thoughts. People are jealous of those who achieve. Don’t let their jealous actions divert your attention. Forgive them for their weakness and believe that you are right and worth it. Health is a gift that you owe yourself. Give it to yourself openly and freely. Your life depends on it. And when you are in doubt come back to this page and read it again. You can do this and you deserve to feel better.

Spoken Words • The power of the spoken word is a much underestimated aspect of developing a positive

belief. What comes out of your mouth has power. If you continually make statements that are self defeating that is exactly what will happen. On the other hand if you continually are saying positive words it will go a long way in your healing program. Words are powerful. The old saying that sticks and stones will break your bones, but names will never hurt you, can’t be more wrong. Words can be devastating whether they are directed at you by someone else or you direct them towards yourself. You must learn to make positive statements about you and your program. A positive verbal daily testament directed towards you will have tremendous effect on your outcome. Avoiding negative talk is not enough. You must incorporate positive words into your daily program. Words can change not only your attitude about yourself, but they can also begin to bring tremendous positive changes in your health. Positive daily affirmations have been linked to curing many serious illnesses such as cancer. Many physicians now believe that patients who make positive statements concerning their health and surroundings have a much better chance of overcoming serious illness. If you are the type of person that walks around being a naysayer, always saying things are bad, you hate your life, you’re too sick to get healthy, then you must turn that off. Just like the remote control that changes the channel on a T.V., you need to change the negative word channel in your brain. Every time you hear yourself saying something negative you need to replace those words with 2 statements about yourself that are positive. You must believe and hear through your own words that you will succeed. After a few weeks of doing this it will become second nature. Not only will you be feeling better due to the program, you will be feeling better about yourself. Thus it will carry you well into the future with beneficial results. Believe and you will Receive, Say and Pave the Way. You need both.

cancer: are we losing the fight?

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