cancer care engineering
DESCRIPTION
Cancer Care Engineering. - PowerPoint PPT PresentationTRANSCRIPT
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CANCER CARE ENGINEERING
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The Health System - Systems Engineering - TRIP - Health Services Research - Policy - Medical Informatics - Economics
Biological Sciences - Blood Biomarkers - Tumor Variations - Tumor Biomarkers/Dynamics mutations - Clinical Trials sessile polyps
INDIVIDUAL PATIENTS- Quality Care - Detection - Susceptibility- Epidemiology - Symptoms / QoL - Environmental Factors- Decision Support - Access
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Accelerated translation of science to practice
Screening Rates
Identified best practices to dramatically improve and personalize tx
Better decision tools that aid providers, managers
A knowledge management system incorporating latest research advances so that every piece of new knowledge does not have to be manually assimilated by every provider
Methods of implementation and systems engineering to address systems complexity and speed of response
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010010010001001001000100110100110100101101101
Matt Burton, MD
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Knowledge of Best and Actual Practices Clinical Pathways, Guidelines, Order Sets, Quality
Indicators
Clinical Workflow Prediction, CDSS, Order Management, Communication,
Care Delivery, and Documentation Simulate, Monitor, and Analyze
Clinical Data Results Delivery, Quality Measurement and Monitoring,
Feedback/forward (CDSS, Simulation), Knowledge Discovery
Virtual Hospital and Cancer Care Engineering
Matt Burton, MD
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Focus on Translation Distill research knowledge to useful products that can be easily used by
providers, consumers, and others to overcome the greatest complexities in cancer care
Goal-Oriented Direct researchers towards overcoming barriers likely to result in the
greatest care system improvements;
Knowledge Improvement Systematic collection, analysis, and dissemination of cancer system data to
all participants for purposes of more effective distributed actions by system participants;
Metric Oriented Drive improvements by using key metrics that summarize system behavior,
such as the NIH statistics cited above;
Global Awareness Understand and direct work by considering it within a system wide
perspective;
Externalize Knowledge Reduce knowledge to models that can be widely learned and whose
properties can be tested for improvement.
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6/17/2008cceHUB S.
Cremaschi 7
System Level: Indiana Regional
Cancer Care System Simulate the Indiana
colorectal cancer (CRC) care system to resemble current performance
Using the model: Identify areas of
potential improvement in current system
Develop and test various strategies to arrive at an optimal strategy
Investigators: Selen Aydogan-Cremaschi, PhD,
Purdue Discovery Park Brad Doebbeling, MD, MSc; Seza
Orcun, PhD, Purdue Discovery Park, David Haggstrom, MD, MAS, Multiple others
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6/18/2008 cceHUB 8
1. Interview providers to identify and rank questions of interest
2. Develop CRC care system models and implement them
3. Validate the model 4. Run what-if scenarios to answer
questions of interest
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6/18/2008 cceHUB 9
9
ScreeningSymptomatic
GeneralPopulation
SurvivorPopulation
Diagnosis
Staging &
Evaluation
Treatment
CancerPopulation
Death
disease free
not treatable or do not wish to be treated
cancer orcare complication or other
false positive
negative
positive
cancer or care complication or other
cancer or care complication or othercancer orcare complication or other
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6/17/2008cceHUB S.
Cremaschi 10
1. Identify higher impact components of the CRC care system in Indiana:
a) From a healthcare system perspective, what indices or metrics might be early warning signals for managers or clinical leaders of where to intervene quickly?
b) If we consider the entire spectrum of care, can we have the greatest impact on CRC care mortality and cost of care by optimizing one of the components to perform in a highly reliable fashion? : --Screening, Screening Follow-up, Diagnosis, Treatment - early stage, late stage diagnosis, survivorship, palliative care
2. Determine necessary system resource capacities:a) If every positive abnormal screening test is followed up with
a colonoscopy, does Indiana have the necessary resources? b) What should the capacity of the high-volume facilities be in
order to be able to perform the necessary surgical procedures for CRC?
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6/18/2008 cceHUB 11
Natural Development and Progression of CRC in Population Agent
NormalInvisible
Polyp Polyp < 1cm Polyp > 1cm
In Situ CRC
Local CRC
Regional CRC
Distant CRC
Prob. ofDev. Polyp
LOP Dist. between States
Symptomatic CRC
LOP Dist. from asymp.
to symp.
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6/18/2008 cceHUB 12
Screening & Follow-up
FOBT
Sigmoidoscopy
Colonoscopy
Never Compliant
Screening Choice Compliance Intervals
Every 1 year
Every 2 years
Every 5 years
One Time Compliant
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6/18/2008 cceHUB 13
Treatment Type Number Combinatio
ns Adherence Date Result Lifestyle
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6/18/2008 cceHUB 14
Attributes Years in training Provider Type, Specialty Location/County Volume of patients/procedures Adherence with “Evidence-Based
Medicine” Treatment maps for CRC stages
using the interviews of CRC providers/specialists.
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6/18/2008 cceHUB 15
Attributes Location Resources
▪ Screening/Diagnosis/Staging▪ Surgery▪ Radiotherapy▪ Chemotherapy▪ Hospice▪ Palliative
Volume of patients/procedures
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System Level: Indianapolis Clinic System
Investigators: PI – Brad Doebbeling, MD, MSc; Co-PI –Jamie Workman-Germann, Purdue
University School of Engineering and Technology at IUPUI
Anticipated Outcome: (1) Develop cancer prevention and care process
maps and quality reports for Indianapolis clinics, (2) understand barriers to best practice care, (3) utilize a Cancer Care – Technical Assistance
Program (TAP) to help implement best practices in one or more clinics.
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CRC Systems Redesign Project Aims:
▪ To understand EMR implementation impact of clinical processes
▪ To optimize patient flow by identifying process barriers to screening
▪ To increase CRC screening rates by removing clinical barriers
Methods:▪ Facilitation of interdisciplinary teams of IUMG and VAMC
primary care clinic staff and area supervisors ▪ Evaluation of existing clinical workflow▪ Systems engineering, Lean, Positive deviance principles
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Scope of Work: Assessment of Primary Care CRC processes Development of data infrastructure to support
sustainability of initiative Develop and administer cultural assessment to
determine organizational readiness for IT and systems redesign initiative implementation.
Facilitate IUMG and VAMC project teams in application of systems engineering tools to:--Design and perform a pilot test of the process redesign, ensuring new processes meet clinical and economic objectives, timeline requirements, and project deliverables--implement new processes and systems with a robust control strategy to ensure long term sustainability of improvements
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System Level: Cross System Information Awareness and Clinic
Investigators: PI - Caroline Carney Doebbeling, MD, MSc, Associate Professor of Medicine
& Psychiatry, IUSM; Research Scientist, IU Center for Health Services & Outcomes Research, Regenstrief Institute, Inc.; Director of Quality and Outcomes, Indiana Medicaid
Co-PI – Katherine Schilling, MLS, EdD, AHIP, IU School of Library and Information Sciences and IU School of Informatics
Specific Aims: (1) Develop a best practice CRC treatment map including recognition and
treatment of cancer-related distress; (2) identify opportunities for streamlining processes; and (3) pilot implementation of more efficient delivery of psychosocial services
(mental health and social work) concurrent with cancer treatment.
Long-term objective is to implement innovative patient screening and navigation systems to consistently deliver optimal psychosocial care.
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CCE-3 – Literature Matrix
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Universal screening in all clinics Distress Thermometer Triage to appropriate CL providers
- Moderate to Severe Distress: Mental health, social work, pastoral services
- Mild Distress: Primary Oncology team Barriers
- Too few providers
- Waiting lists
Recommendation : Can we identify, describe, and better understand “positive deviant” systems within treatment centers nationally that are engaged in best practices? How have they been successful in implementation?
CCE-HSR C. Carney Doebbeling
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System Level: System Biology-Oncologist-Patient
Investigators: PI – Seza Orcun, PhD, Purdue Discovery Park Co-PI – Doraiswami Ramkrishna, PhD, Harry Creighton Peffer
Distinguished Professor of Chemical Engineering, Purdue Co-I – Eric Sherer, PhD, Purdue Discovery Park; VA Center of
Excellence on Implementing Evidence-based Practice; Tom Imperiale, MD, Professor of Medicine, IU School of Medicine and IU Center for Health Services & Outcomes Research, Regenstrief Institute
Anticipated Outcome: (1) Develop a population balanced model to predict efficacy of
oncology treatment, (2) validate model with oncologist usage, and (3) engineering modeling researchers in clinical settings partnering
on joint projects with oncologists, GI specialists and services researchers.
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1. CRC prevalence model that includes intermediate polyp states and tumor genetic heterogeneity
1. Already several similar models for incidence2. None (that we know of) that include polyps or branching
2. Methodology to extract a minimal set of discrete patient model parameter sets from CRC & polyp prevalence / incidence data
1. Parameter sets are independent of demographics
=> Bayesian model for predicting likely parameter sets for an individual patient
1. Certain demographics may be more likely for certain parameter sets
2. Likelihoods adjust to additional patient information3. Predict incidence, treatment outcome, outcome
05/28/08 CCE-HSR E. Sherer
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System Level: Cross System Information Awareness – Assimilation and
Integration of Data From All Projects
Investigators: PI – David S. Ebert, PhD, Professor of Electrical and
Computer Engineering, Director of Purdue University Regional Visualization and Analytics Center, Director of Purdue University Rendering and Perceptualization Lab, Purdue
Primary Objective: Full-fledged, interactive, integrated visual and statistical
analysis capability in a vital analytic environment that brings together massive, disparate, incomplete and time-evolving -omic data sets.
Longer term goal---linkage with systems level data—cross projects with EMR, claims, structure, process, outcomes
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“The Dashboard Project” Initial pilot, creation of an interactive,
integrated dashboard of facility-level colorectal cancer performance measures to inform the process of cancer care and systems management in the VAMC.
An example of functionality would be the ability to view CRC-related, facility-wide data output by clinics, treatment providers or risk-level of patient populations.
Brad Doebbeling, MD, MSc; Selen Aydogan-Cremaschi, PhD,; Matt Burton, MD; Timothy Carney, MPH, MB,;Jason Saleem, PhD; Darrell Baker, RN; David Haggstrom, MD; Tom Imperiale, MD; Charles Kahi, MD, and Chris Suelzer, MD
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Dashboard Report – Corporate View
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Critical, Clinically-Relevant Questions of Interest:
What percentage of patients who have received physician-ordered FOBT cards, are not returning them? What factors are contributing to non-compliance?
Regarding follow up after a positive FOBT screen, what percentage of patients is notified within the required 14 days of the results?
What percentage of patients with colonoscopy orders to follow-up for positive screens isn’t getting colonoscopy completed? What factors are contributing to this gap?
What percentage of patients with a positive screen get needed colonoscopy within the required 30 days?
06/08 CCE-HSR B. Doebbeling
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Aug2008
-Project kick-off
Feb 2008
-Questions of Interest-Interview VAMC CRC care providers & administrators-Identify critical questions of interest-Identify CRC performance measures for visualization
-Detailed Definitions of CRC Performance Measures
Apr 2008
May2008
June2008
-Review -Literature for dashboards for healthcare system-Implemented healthcare dashboards
-Conceptual Design of Dashboard
Sep2008
-Database & Software Selection
-Mock Implementation
Oct2008
Dec2008
-Usability Testing & Dashboard Refinement
INITIATION PHASE PHASE I PHASE II
-Prototype Implementation and Testing
-Dissemination-Proposal Development
June2009
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System Level: Repository of Data for All CCE Projects, Preparation of
Data From All Projects, and Strategic Statistical Analysis
Investigators: PI – Marietta L. Harrison, PhD, Purdue University; Co-I,
Laura Jones Myers, PhD, George Allen, IU School of Medicine & VA COE
Anticipated Outcome: (1) Utilitarian project to provide an electronic repository
of all CCE project data, (2) Develop a procedure and tools for cleaning and
validating CCE project data, and (3) Determine a strategy for combining and analyzing
the disparate data from all projects
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30
Aim 1: Identify key approaches to CDS development for CRC screening at two VAMC sites and two nationally recognized non-VA sites, for effective CDS integration into clinical workflow.
Aim 2: Develop and test CDS design alternatives for improved integration into clinical workflow through a controlled simulation study and subsequent implementation.
Research Team: Brad Doebbeling, MD, MSc (PI); David Haggstrom, MD, MAS; Jason Saleem, PhD ; Laura Militello, MA; Heather Hagg, MS; Shawn Hoke and Lori Losee, and West Haven VA, Columbia, South Carolina VA, Partners Healthcare (Harvard).
Social Subsystem
Technological Subsystem
External Environment
Organizational Structure / Work System Design
Joint Optimization
Social Subsystem
Technological Subsystem
External Environment
Organizational Structure / Work System Design
Joint Optimization
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Training and research components: Aim 1: To identify patient-level characteristics
associated with underuse & overuse of surveillance care among CRC survivors colonoscopy, CT scans, CEA tests, history & physical
Aim 2: To determine whether organizational or physician characteristics are associated with the quality of CRC surveillance care
Aim 3: To develop and test a CRC survivor’s personal health record that promotes high-quality follow-up care
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Develop methods and tools for effective use of unstructured data such as narrative text in VA EHR
Improve text processing, text mining and de-identification capabilities
Applied projects Seven VAMCs with informatics research
capabilities participating--Salt Lake City, Nashville TVHS, Indianapolis, Palo Alto, Portland, Tampa, West Haven. Also Boston – MAVERIC, Pittsburgh-Philadelphia, Mayo Clinic, Carnegie Mellon.
Ability to extract free (tumor stage, etc) through a web services model.
[See Len D’Avolio, Mahesh Merchant, Matt Burton]
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Innovation, Interdisciplinary Collaboration, Focused on transforming Healthcare
Positive impact on healthcare
Reduction in cost of healthcare delivery
Increase in the value of healthcare delivery
Translating the project results to the benefit of the healthcare system
Possibility to leverage the Foundation, DoD, VA and AHRQ funding
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Knowledge Patient with given demographic needs a Colonoscopy every 10 yrs
Clinical Workflow Pt J. Doe scheduled for routine H&P plan for Colonoscopy in next 3 mos. w/
PCo Clinical Reminder: “Dr. Smith, J. Doe needs a Colonoscopy” CPOE: “Colonoscopy for J. Doe is ordered and signed” Order Mgmt: “Colonoscopy for J. Doe scheduled on 7/12/08” Resource/ Supply Mgmt: “Need Colonoscopy suite, resources, and supplies
on 07/12/08 at 9:00AM for Pt with give requirements” Registration: “J. Doe has arrived for his Colonoscopy” Document Preparation: “Populate fields in Procedure Note for Colonoscopy” Documentation: “Colonoscopy begun/ completed at 9:03 AM/ 9:37 AM
7/12/08” Order: “Path Specimen for Polyp” Document Preparation: “Populate fields in Path Report on Joe Doe’s Polyp”
Clinical Data Preliminary Procedure Note for Colonoscopy on 7/12/08 is resulted Pathology Report on Colonoscopy on 7/12/08 is signed and resulted
Matt Burton, MD
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System Level: Indiana Regional Cancer Care System
Investigators: PI – Selen Aydogan-Cremaschi, PhD, Assistant
Research Scientist, Purdue Discovery Park Co-PIs – Bradley N. Doebbeling, MD, MSc; Seza
Orcun, PhD, Associate Research Scientist, Purdue Discovery Park
Anticipated Outcome: A model that can explain the existing CRC care
system data, answer “what-if” questions about potential changes to the care system, and suggest improvements based on analyzing various options.
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Mechanistic modeling of colorectal cancer (CRC) Includes genetic mutations and growth /
death dynamics Hypothesize mechanisms
▪ Underlying knowledge▪ Level of detail determined by measurements▪ Can be extended to incorporate additional
information as it becomes available Prediction of likely individual patient CRC
Temporal likelihoods of CRC Likely properties of CRC
05/28/08 CCE-HSR E. Sherer
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System Level: Clinical
Project Team: PI – Brad Doebbeling, MD, MSc Co-Is – Selen Aydogan-Cremaschi, PhD, Assistant Research
Scientist, Purdue Discovery Park, VA HSR&D COE; Matt Burton, MD, Medical Informatics Fellow, Regenstrief Institute, Inc.; Timothy Carney, MPH, MBA, IU School of Informatics; Jason Saleem, PhD, Assistant Professor, VA COE and IUPUI School Engineering & Tech; David Haggstrom, MD, MAS, Assistant Professor, IU School of Medicine, VA CIEBP and IU CHSOR
Consultants – Darrell Baker, RN, Clinical Applications Coordinator, VAMC;; Tom Imperiale, MD, Research Scientist, Regenstrief Institute, Inc. and IU School of Medicine; Charles Kahi, MD, Roudebush VA Medical Center and Chris Suelzer, MD, Associate Chief of Staff for Ambulatory Care, Roudebush VA Medical Center
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More effective use of IT is recommended in integrating point of care access to (e.g., Committee on Quality Health Care in America): Health literature and evidence-based guidelines; Computerized clinical data; Computerized decision support (CDS) systems; Automation of decisions to reduce errors; Electronic communication among providers and patients into
practice. Computerized CDS can improve clinician decision making and
support adherence to evidence-based guidelines. Colorectal cancer screening focus: high disease burden, relatively
low screening rates, strong evidence for screening effectiveness Failure to optimally integrate CDS into workflow has resulted in
inconsistent and incomplete implementation strategies.
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Disparities in hospital selection Cultural disparities Gender & Age
Diagnosis at younger age = higher risk for psychosocial problems related to illness burden
Racial disparities (??) Literacy and Health Literacy
Low health literacy associated with less knowledge about colorectal cancer
Low health literacy associated with less knowledge about screening
Practical, life-management issues (insurance, employment)
Lower income, Medicare Part D issues Ability of providers to recognize distress
05/28/08 CCE-HSR K. Schilling
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System Level: Physical CRC Sample and Raw Data Collection
Investigators: PI – Stephen D. Williams, MD; Gabi Chiorean, MD,
IU Simon Cancer Center, IU School of Medicine
Anticipated Outcome: Augments a DoD-funded project to collect
additional samples and clinical data based on an analysis of initial results.
To assess physical samples and laboratory analysis data from the CPTAC project and other Indiana based cancer specimens for purposes of understanding Indiana’s capacity for a total cancer care engineering project.
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System Level: Opportunistic Project Refinement and
Integration of Regional and National Assets into Indiana CRC CCE Effort
Investigators: PIs – Joe Pekny, PhD, Purdue University;
Brad Doebbeling, MD, MSc, Indiana University
Primary Objective: Management of the portfolio of all projects
to maximize impact and to leverage success by further incremental investment