Capillary Electrophoresis and Liquid Chromatography Taken to the Next Level

SCIEX SEPARATIONS PRODUCT OVERVIEW

Powerful Separation Technologies and MS Connectivity

Capillary electrophoresis (CE) and liquid

chromatography (LC) are among the most

powerful analytical tools available to

scientists today.

SCIEX is expanding the power of these

technologies to provide you a faster path to

results. Particular CE instruments and all of our

LC instruments are designed for connectivity to

SCIEX mass spectrometers.

CAPILLARY ELECTROPHORESIS

LIQUID CHROMATOGRAPHY

CHEMISTRIES AND APPLICATIONS

In addition to LC columns, chips, cartridges and capillaries, a wide variety of application kits are offered for use on SCIEX instruments to simplify and ensure rapid and successful implementation of methods and applications. Our most popular chemistries are:

Extensive Range of Chemistries and Applications

Biologics Analysis

• IgG Purity and Heterogeneity

Determination

• Charge Heterogeneity

Analysis

• Carbohydrate Labeling

and Analysis

• Ion Analysis

Genetic Analysis

• DNA Sequencing

• Gene Expression

• Genotyping and SNP Analysis

• STR Analysis

• Microbial Testing

Biomarker Discovery and

Omics Research

• iTRAQ® Reagent

• mTRAQ® Reagent

• Cleavable ICAT Reagent

• Protein Preparation

• Trypsin

Clinical Research

• aTRAQ™ Reagent

• Amplifex™ Diene Reagent

• Amplifex Keto Reagent

Drug Discovery and Development

• CYP450 Induction Assay

Food and Environmental

• iDQuant™ Standards Kits

CAPILLARY ELECTROPHORESIS

LIQUID CHROMATOGRAPHY

CHEMISTRIES AND APPLICATIONS

Capillary Electrophoresis See what you couldn’t see before.

CESI 8000 Plus High Performance Separation-ESI Module

CESI is a groundbreaking technology that integrates capillary electrophoresis (CE) with electrospray ionization (ESI) into a single dynamic process. The entire sample path is one dimension, from inlet to outlet, without connections, avoiding dead volumes and clogging. CESI-MS is ideal for the analysis of charged and polar analytes, common in biologics, proteomics and metabolomics.

• Multiple injections from 5 µL

• Stable spray is achieved at ultra-low flow rates (<10 nL/min.)

• Increased ionization efficiiency increases sensitivity and virtually elimnates ion suppresion bias

• No detectable sample carryover

• Intact protein analysis abilities

PA 800 Plus Pharmaceutical Analysis System

The PA 800 Plus Pharmaceutical Analysis System is ideally suited for characterization of intact biologics. Independent collaborations across biopharmaceutical companies have demonstrated excellent assay portability, enhancing the overall system utility in multi-user, multi-instrument facilities found in today’s global biopharmaceutical organizations.

• IgG purity and heterogeneity using SDS-gel chemistry

• Charge heterogeneity by CZE and advanced cIEF

• Fast microheterogeneity determination by N-linked Oligosaccharide labeling and analysis

• UV-Vis, PDA, and solid state LIF detection configurations with accompanying chemistries available

Extending the Reach of Your Mass Spectrometer

Proven for Analytical Characterization of Biologics

P/ACE™ MDQ Plus Separation System

The P/ACE MDQ Plus is an automated, programmable system that performs fast separations of analytes from complex samples for many different research projects and industrial applications including biological sciences, chemistry, forensic science, food and beverage, biofuels, environmental safety and more. The exclusive circulating liquid coolant precisely regulates capillary temperature more efficiently delivering resolution and reproducibility from challenging separations that require the use of high-ionic strength buffers.

• Integrated interchangeable UV, Diode Array, and LIF modular detectors

• Internal fluidic system generates pressure or vacuum

• Sample from vials, micro vials, or 96-well plates

• Multi-mode sample introduction from as little as 5 µl

GenomeLab GeXP™ Genetic Analysis System

The GenomeLab GeXP Genetic Analysis System is a versatile multi-functional genetic analyzer based on sensitive laser induced fluorescent detection capillary electrophoresis technology, with a wide 3 logs of dynamic detection range. The system is capable of performing a large number of applications using a single setup with one gel, one capillary array, and one software program.

• Multiplex gene expression and microbial ID incorporating XP-PCR technology

• Dye terminator cycle sequencing (high quality long and short reads)

• SNP detection using Single Base Extension (SBE) technology

• Genotyping by STR, RFLP and MLVA

• Amplified fragment length polymorphism (AFLP) fingerprinting

Fast High Resolution Separations and Quantitation of Polar and Charged Analytes

All Genetic Analyses on One Instrument

•

M3 MicroLC System

You have limited sample volume available and need high-throughput processing. The SCIEX M3 MicroLC System has been developed for the sensitivity, ease of use, and throughput needs of biopharmaceutical development.

• Maintain high throughput while increasing sensitivity (up to 10x of improved LLOQ)

• Use less sample, allowing for multiple analyses

• Save up to 90% of solvents

• Space saving: stackable on top of SCIEX Triple Quad™ and QTRAP® LC-MS/MS systems

• Flow rate range from 5 µL /min to 200 µL /min

Sensitivity and Throughput for Precious Samples

Liquid Chromatography that Performs 24/7

Flow rates that fit your unique needs.

•

ExionLC™ Systems

Your LC-MS laboratory has unique analytical requirements. Our goal is to provide LC-MS solutions tailored to meet your needs. SCIEX introduces the ExionLC Series of robust and reliable HPLC/UHPLC systems offering a wide range of performance and flexibility for analytical-scale separations.

• ExionLC 100 - Simplified, and affordable (6,000 PSI )

• ExionLC AC - Reliable and expandable (9,500 PSI)

• ExionLC AD - Full UHPLC capability (18,000 PSI)

NanoLC™ 400 System with cHiPLC® System

The NanoLC 400 system offers an additional level of flexibility with plug-and-play flow modules that enable easy switching from high-sensitivity nano-flow for discovery, to high throughput micro-flow for validation. The excellent reproducibility supports the latest in data-independent quantitative proteomics workflows like MS/MSALL with SWATH® Acquisition.

• Flow rate range from 100 nL/min to 50 µL/min

• Splitless MFCPlus™ Technology for improved reproducibility

• Pressure up to 10,000 PSI

Unmatched FLexibility for Low Flow LC-MS

Complete. Reliable. Expandable.

AB Sciex is doing business as SCIEX.

© 2015 AB Sciex. For Research Use Only. Not for use in diagnostic procedures. The trademarks mentioned herein are the property of AB Sciex Pte. Ltd. or their respective owners. AB SCIEX™ is being used under license.

RUO-MKT-07-2596-A 12/2015

Your Success is Our SuccessWe take it personally

As a SCIEX customer you have access to a world-class customer support organization.

Wherever you are, we’re there with you as a trusted partner to answer questions, provide

solutions, and maximize lab productivity.

Our customer support organization has access to the latest product updates, software

revisions, methods and repair procedures to make sure that you stay on top of your game.

When you have questions, we have answers.

Learn more at sciex.com/customersupport, or locate your local account representative

at sciex.com/contactus

Headquarters 500 Old Connecticut Path Framingham, MA 01701 USA Phone 508-383-7700 sciex.com

International Sales For our office locations please call the division headquarters or refer to our website at sciex.com/officesAnswers for Science.

Knowledge for Life.™