carbon ion fragmentation study for medical applications protons (hadrons in general) especially...
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Carbon ion fragmentation study for medical applications
Protons (hadrons in general)especially suitable for deep-sited
tumors (brain, neck base, prostate)and fat people
G. De LellisNapoli University
Dose modulation
From the overlap of close peaks (close energies) , conformational
Profile is obtained
The patient is rotated so to avoid a long exposure time of the
healthy tissues
Size of the sick part
Carbon beam
Same energy deposit profile as protons but with larger energy loss per unit length
one ionization every ~ 10nm
(DNA helix ~ 2nm)
Charge and mass measurement
• Density of energy along the track path Z2
• Multiple scattering or magnetic field provides either p or p
• From the combined measurement, we can get p and the mass A,Z
Exposure of an ECC to 400 Mev/u Carbon ions
ECC structure: 219 OPERA-like emulsions and 219 Lexan sheets ( = 1.15 g/cm3) 1 mm thick (73 consecutive “cells”)
exposed to 400 Mev/u Carbon ions
Cell structure
LE
XA
N
LE
XA
N
LE
XA
N
R0 R1 R2
R0: sheet normally developed after the exposure
R1: sheet refreshed after the exposure (3 days, 300C, 98% R.H.)
R2: sheet refreshed after the exposure (3 days, 380C, 98% R.H.)
Carbon exposure at HIMAC (NIRS-Chiba)
C ions angular spectrum
Slope X
Slo
pe
Y
slope X
(3 )
slope Y
(3 )
P1-0.150 ±0.004
-0.003 ±0.005
P2-0.017 ±0.004
-0.002 ±0.005
P3 0.134 ±0.004
-0.001 ±0.005
3.4 cm2 scanning in each sheet (all sheets scanned)
Track volume: sum of the areas of the clusters belonging to the track
BG, mip
Z > 1
p
Upstream sheet
Downstream sheet(about 5 cm)
p Z > 2
one sheet – R0 type one sheet – R1 type
Downstream sheet(about 5 cm)
Upstream sheet
R0 vs R1 and R1 vs R2 scatter plot
H
He
He
R1 versus R2
HeLi
Be
B
C
20 to 30 sheets5 to 10 sheets
Charge identification
Z = 2
Z = 3
Z = 4
5 R1 VS 5 R2 (2 cm) 10 R1 VS 10 R2 (4 cm)
15 R1 VS 15 R2 (6 cm)
20 R1 VS 20 R2 (8 cm)
Z = 4
Z = 3
Z = 2
Z = 5
Z = 6
Charge separation
Charge separation versus the number of segments
Helium-Lithium Lithium-Beryllium
Charge separation versus the number of segments
Boron-CarbonBeryllium-Boron
Charge identification efficiency
One vertex
C
3 cm
Vertex analysis
Impact parameter distribution
Track multiplicity at interaction vertex
Charge distribution of secondary particlescharge reconstruction efficiency
Inefficiency Charge = 0Charge efficiency = (2848-27)/2848 =
99.1±0.2%
Sum of the charge at the interaction vertex
Carbon interactions
Bragg peak
Contamination at the percent level
Angular distribution of secondary particles
Particle ranges for different charges
Ranges and interaction lengths for stopping and interacting particles
Elastic scattering angle
~ 6% Contamination
Conclusions• The charge identification works well up to the Carbon• The charge separation capability is about 5 sigma for
protons and helium already with less than 10 plates where other detectors fail
• The separation between boron and carbon requires 30 plates to reach 2.5 sigma
• The vertex reconstruction works with impact parameters of 10 µm or less
• Elastic and anelastic scattering are well separated
Outlooks•Improve the identification capability for short tracks
•Measure the momentum for isotope discrimination