Reactions 1486, p11-12 - 1 Feb 2014

SCarboplatin/nedaplatin

Hypersensitivity reaction: 15 case reportsFifteen female patients with gynaecological cancer, aged

47–67 years, experienced hypersensitivity reactions whilereceiving carboplatin. Four of the women subsequentlydeveloped hypersensitivity reactions while receivingnedaplatin; cross-reactivity between carboplatin andnedaplatin was suspected. The women were part of a studyevaluating the safety and efficacy of nedaplatin treatmentfollowing the onset of carboplatin-associated hypersensitivityreactions. They each received between eight and 31 cycles ofcarboplatin, at a total dosage of between 3300mg and17 175mg [routes not stated]. All 15 women experiencedhypersensitivity reactions of either grade 2 or 3 [duration oftherapies to reaction onsets not stated, outcomes not stated].They each subsequently received IV infusion nedaplatin80 mg/m2. The total dose of nedaplatin administered to eachwoman ranged from 120–3190mg over 1–29 cycles. Twowomen experienced grade 2 hypersensitivity reactions witheither rash or dyspnoea, and two women experienced grade 3reactions with either oedema or hypotension. Hypersensitivityreactions occurred during the second cycle of treatment in twopatients, the fourth cycle of treatment in one patient, and theninth cycle of treatment in one patient. All four patientsdiscontinued nedaplatin. Eleven women received nedaplatinwithout adverse effect.

Author comment: "In this study, we evaluated the safetyand efficacy of retreatment with nedaplatin in patients whohad developed carboplatin-associated HSRs. . . four (27%) ofthem experienced [hypersensitivity reactions] to nedaplatinduring their treatment. This incidence suggested that cross-reactions between nedaplatin and carboplatin might occur atsubstantial frequency".Arimoto T, et al. Retreatment with nedaplatin in patients with recurrentgynecological cancer after the development of hypersensitivity reaction tocarboplatin. Journal of Obstetrics and Gynaecology Research 39: 336-340, No. 1,Jan 2013. Available from: URL: http://doi.org/10.1111/j.1447-0756.2012.01917.x -Japan 803098751

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Reactions 1 Feb 2014 No. 14860114-9954/14/1486-0001/$14.95 Adis © 2014 Springer International Publishing AG. All rights reserved