cardiac catheterization techniques in pulmonary hypertension
TRANSCRIPT
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Cardiol Clin 22 (2004) 401–415
Cardiac catheterization techniques in pulmonaryhypertension
Paulo Guillinta, MD, Kirk L. Peterson, MD, Ori Ben-Yehuda, MD*Division of Cardiology, Department of Medicine, University of California, San Diego,
200 West Arbor Drive, San Diego, CA 92110, USA
Once considered dangerous and potentially life
threatening, cardiac catheterization of the patientwith pulmonary hypertension can be performedsafely and provides essential information in thediagnosis and management of pulmonary hyper-
tension. This article summarizes the moderntechniques used for right-heart catheterization,selective pulmonary angiography, and pulmonary
angioscopy in the evaluation of the patient withpulmonary hypertension or with suspected chron-ic thromboembolic disease.
Cardiac catheterization of the patient withsuspected pulmonary hypertension is essential todetermine accurately the cause and extent ofdisease. In patients with suspected chronic throm-
boembolic pulmonary hypertension (CTEPH),pulmonary angiography remains an essentialpart of the diagnostic evaluation and selection
of appropriate patients for surgical pulmonarythrombendarterectomy. Although historically pul-monary angiography has been considered contra-
indicated in the presence of severe pulmonaryhypertension, advances in cardiac and pulmonaryangiographic techniques allow this procedure to be
performed in a safe manner with acceptable risk. Inreviewing the technique of right-heart catheteriza-tion, pulmonary angiography, and angioscopy inthe patient with pulmonary hypertension, the
authors draw on the experience of more than 20years of catheterization of patients with severepulmonary hypertension at the University of
California, San Diego (UCSD) Medical Center,
* Corresponding author.
E-mail address: [email protected]
(O. Ben-Yehuda).
0733-8651/04/$ - see front matter � 2004 Elsevier Inc. All r
doi:10.1016/j.ccl.2004.04.011
where more than 2500 such procedures have beenperformed.
Indications and considerations for catheterization
of the patient with pulmonary hypertension
Catheterization plays an integral part in the
evaluation of the patient with pulmonary hyper-tension. The primary goals of catheterization areto determine right ventricular and pulmonary
artery hemodynamics, to exclude left-to-rightcardiac shunts and any significant left-sided car-diac disorder, to assist in the determination of thecause of pulmonary hypertension, and to test the
response of therapeutic agents. In patients withsuspected CTEPH, pulmonary angiography andangioscopy are used to assess clot location, extent,
and size to determine candidacy for pulmonarythrombendarterectomy.
Safety considerations
Early case reports [1–4] of fatalities associatedwith pulmonary angiography in patients withpulmonary hypertension have led to a lingering
perception that the procedure is associated withconsiderable risk, primarily because of acute rightventricular failure and arrhythmias. Even right-
heart catheterization alone [5] was reported to bepotentially dangerous. Larger series have sincebeen published, both in acute and chronic pulmo-nary embolism and in mild as well as severe
pulmonary hypertension. Mills et al [6] describedthree deaths in 1350 patients (incidence of 0.2%),all of whom had right ventricular end diastolic
pressure of 20 mm Hg or higher. Nicod et al [7]
ights reserved.
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402 P. Guillinta et al / Cardiol Clin 22 (2004) 401–415
reported on the original series of 67 patients fromUCSD undergoing CTEPH evaluation. Meanpulmonary arterial pressures (PAPs) were 47 �13 mm Hg, with a right ventricular end diastolicpressure of 13 � 6 mm Hg and a cardiac index of2.2 � 0.7 L/min. There were no deaths attribut-able to CTEPH. By 1991 this series had expanded
to include more than 300 patients, without a death.Since then right-heart catheterization and pulmo-nary angiography have been performed in ap-
proximately 200 patients with severe pulmonaryhypertension annually at UCSD, without a deathrelated to the procedure (more than 2500 patients
to date). There thus are no absolute contra-indications to pulmonary angiography, and theprocedure can be performed safely, providedcertain precautions and advances in technique
are employed.Nonfatal adverse reactions include transient
hypotension and general catheterization-related
adverse events such as inadvertent arterial punc-ture, oversedation, pneumothorax, and contrastagent–related nephropathy [8]. To minimize these
risks, the authors use the following procedures atUCSD [9]:
1. Before the procedure echocardiography isperformed, detecting potential clots in theright atrium or right ventricle or the presence
of an atrial septal defect/patent foramenovale.
2. Heart rate, rhythm, oxygen saturation, and
systemic and PAP should be continuouslymonitored. Supplemental oxygen is providedto maintain oxygen saturation over 90%.
3. Access to the pulmonary vessels through theneck is preferred to avoid potential dislodge-ment of unsuspected venous thrombi involv-
ing the femoral vein, iliac vein, or inferiorvena cava and to facilitate angioscopy. Theauthors prefer the internal jugular vein to thesubclavian vein to reduce the risk of pneu-
mothorax, which is likely to be poorlytolerated in these patients who are oftenhypoxemic.
4. Hemodynamics are assessed using a balloonflotation catheter (Swan-Ganz catheter), attimes stiffened with a 0.025-cm guide wire.
This stiffening greatly facilitates the catheter-ization in these patients, who frequentlyhave enlarged right ventricles, significanttricuspid regurgitation, severely elevated
PAPs, and low cardiac output. CO2 is usedfor balloon inflation to minimize the possi-
bility of paradoxical embolism in case ofballoon rupture.
5. A stiff, side-hole catheter such as a 7-F or 8-F
NIH or Berman catheter is most commonlyused to inject the pulmonary arteries. Theinjection through the side holes allows goodopacification with reduced injection velocity
and pressure. Catheter retraction and whip-ping during injection are also minimized.
6. Unilateral, sequential injection of the contrast
agent in to each main pulmonary artery ispreferred. Injection into the right atrium orright ventricle is avoided, thereby eliminating
the possibility of intramyocardial injection.The catheter is positioned near the origin ofthe lower lobe vessels, and the contrast agentis allowed to fill the upper lobes in retrograde
fashion.7. Non-ionic contrast is preferred because fewer
adverse reactions and minimal hemodynamic
compromise are experienced [10,11].8. Cardiac output and speed of run-off during
small hand injection are used to determine the
amount of contrast agent needed for assess-ment of the pulmonary vasculature anatomy.A smaller amount of contrast material is
needed in patients with slow run-off or lowcardiac output. At UCSD, the total amount ofcontrast medium used ranges from 20 to 65mL. The usual injection is of 55 mL at a rate of
22 mL/second, with adjustments based on thepatient’s cardiac output, assessment of thepulmonary vasculature during the hand in-
jection, and pulmonary pressures. For exam-ple, the total occlusion of the main descendingpulmonary artery after the takeoff of the
upper lobe branch would necessitate a reduc-tion of the total contrast to approximately 20mL. Conversely, the presence of a brisk runoffduring the hand injection coupled with a high
cardiac output would lead to injection of morethan the standard 55 mL.
Right-heart catheterization
Evaluation of hemodynamics by right-heartcatheterization plays an integral part of theevaluation of patients with pulmonary hyperten-
sion. The goals of right-sided catheterization are(1) to measure PAP directly and estimate pulmo-nary vascular resistance, (2) to evaluate for left-to-
right shunts, and (3) to test the response totherapeutic agents.
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403P. Guillinta et al / Cardiol Clin 22 (2004) 401–415
During right-heart catheterization by balloonflotation catheter, rapid determination and contin-uous monitoring of pressures in the right ventricle,right atrium, and pulmonary artery and of post-
capillary wedge pressure are possible. Understand-ing of normal and pathologic pressure waveformsis important to recognize certain cardiac disorders
such as valvular and pericardial disease. In patientswith primary pulmonary hypertension (PPH),particular attention should be paid to the right
atrial pressure and right ventricle end-diastolicpressure. In the National Heart Lung and BloodInstitute registry, mean right atrial pressure and
decreased cardiac index were the most importantpredictive variables for survival in patients withPPH [12]. The patient with PPH commonly haselevated right atrial pressure, elevated mean PAP,
reduced cardiac index, and low or normal post-capillary wedge pressure [8].
A postcapillary wedge pressure is obtained with
an end-hole catheter positioned in a side branch ofthe pulmonary artery facing a pulmonary capillarybed. One pitfall to avoid is wedging the balloon too
proximally, creating a hybrid tracing of pressuresbetween actual PAP and postcapillary wedgepressure, resulting in an overestimation of the
postcapillary wedge pressure (Fig. 1). Deflatingthe balloon to decrease its size will allow thecatheter to be wedged in a smaller, more distalbranch of the pulmonary artery. Caution should be
taken to avoid overwedging and possible pulmo-nary artery rupture, a potentially lethal event.Fortunately in pulmonary hypertension the thick-
ened, hypertrophied arterial wall provides someprotection against rupture. When it is not clearwhether awedge tracing has been obtained, a blood
sample is obtained through the distal port. In thewedge position arterial saturation should be pres-ent as blood from the capillary bed is aspirated.The authors have also found that typically the
more narrow, tapering anatomy of the left pulmo-nary artery allows more reliable wedge determi-nations. The use of a J-tipped 0.25 wire to guide the
Swan-Ganz catheter to the left pulmonary artery isessential. Typically patients with either PPH orCTEPH have low to normal wedge pressures.
In the presence of substantially elevated postcap-illary wedge pressure, left-heart catheterizationshould be performed to exclude pulmonary veno-
occlusive disease, mitral stenosis, or left ventriculardysfunction.
Cardiac output is best determined by the Fickmethod in the setting of low cardiac output states
or when there is significant tricuspid regurgita-
tion. This method requires measuring oxygenconsumption directly, because estimations ofoxygen consumption may not apply to seriouslyill patients with pulmonary hypertension and may
introduce significant calculation errors. In experi-enced hands, however, determination of cardiacoutput by thermodilution techniques is usually
satisfactory for the adjustment of therapy in thesepatients [13].
Response of vasodilator challenge in the cardiac
catheterization laboratory
Vasoconstriction of the pulmonary vessels is
one of the prominent pathologic features seen inpatients with pulmonary hypertension of anycause, particularly in those with PPH [14]. Un-fortunately, no hemodynamic or demographic
characteristics exist to predict which patients arelikely to benefit from long-term vasodilator ther-apy [15,16]. In more recent studies, Groves et al
[17] illustrated that the initial response to vaso-dilatory therapy accurately predicts the patientwith PPH who is likely to benefit from long-term
oral therapy. In addition, patients who demon-strate a reduction in total pulmonary resistanceindex of more than 50% in response to short-termepoprostenol (prostacyclin, PGI2) challenge at the
time of diagnosis had longer disease evolutionsand better prognoses than patients with a lowervasodilator response [18,19]. For these reasons [3],
it is important to assess the response to vasodila-tor therapy in patients with PPH in the cardiaccatheterization laboratory.
Nitric oxide and PGI2 are useful drugs to testpulmonary vasoreactivity because they are potent,short acting, and can be titrated. The acute effects
of inhaled nitric oxide and PGI2 on pulmonaryartery pressure are similar [20,21]. Inhaled nitricoxide more consistently reflects the changes inpulmonary vascular tone and seems to be the
better predictor of the long-term response to oralvasodilator treatment, making it the preferredagent for assessing pulmonary vasoreactivity [22].
Nitroprusside has fallen out of favor forassessing pulmonary vasoreactivity in patientswith chronic pulmonary hypertension because this
drug causes systemic hypotension compared withnitric oxide, at doses that cause similar degrees ofpulmonary vasodilation [23].
Pulmonary arterial pressures, right ventricularpressures, cardiac output, and postcapillary wedgepressure are recorded during infusions of inhaled
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404 P. Guillinta et al / Cardiol Clin 22 (2004) 401–415
Fig. 1. (A) Hybrid tracing of pulmonary artery pressure and wedge tracing overestimating wedge pressure. (B) Actual
pulmonary capillary wedge pressure tracing once the balloon is deflated and allowed to wedge in a smaller, more distal
branch of the pulmonary artery.
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405P. Guillinta et al / Cardiol Clin 22 (2004) 401–415
nitric oxide. Administration of inhaled nitricoxide with oxygen seems to be safe and providesadditional pulmonary vasodilation in this patientpopulation [24]. Pulmonary pressure are recorded
during administration of 100% oxygen and in-haled nitric oxide dosed at 20 to 80 parts permillion. The authors typically administer nitric
oxide for 10 minutes, with repeat recordingsobtained during the final 5 minutes of the in-halation. Although a mild reduction in pulmonary
vascular resistance (<20%) can be seen in mostpatients, even those with CTEPH, significantreductions of more than 20% are seen in only
one fourth of patients [25].
Pulmonary angiography: anatomy
Accurate evaluation of the pulmonary angio-
gram requires knowledge of the pulmonary vas-
culature anatomy (Figs. 2 and 3). The mainpulmonary artery arises from the pulmonaryconus of the right ventricle, anterior and to theleft of the aorta. It takes a posteromedial direction
until its bifurcation into the right and left pulmo-nary arteries. The right pulmonary artery coursesanterior to the right mainstem bronchus. It gives
rise to the right upper lobe branch within themediastinum. The left pulmonary artery passesover the left mainstem bronchus and descends
posterior to the bronchus before the origin of theleft upper lobe branch. The vessels then branchand are closely related to bronchial branching
within the lung. Angiographic films are takenusing anteroposterior and lateral projections. Thelateral projection is particularly helpful in sepa-rating the overlapping tributaries of the right
middle and right lower lobe and left lingual andleft lower lobe. It also allows a clear separation
Fig. 2. (A) Anteroposterior view of the anatomy of the right pulmonary artery. (B) Lateral view. (Reproduced from
Peterson KL, Nicod P. Catheterization and angiography in pulmonary hypertension. In: Shure D, Auger W, Moser K,
et al, editors. Cardiac catheterization: methods, diagnosis, and therapy. Philadelphia: W.B. Saunders; 1977. p. 404;
with permission.)
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406 P. Guillinta et al / Cardiol Clin 22 (2004) 401–415
Fig. 3. Anatomy of the left pulmonary artery in (A) anteroposterior and (B) lateral views. (Reproduced from Peterson
KL, Nicod P. Catheterization and angiography in pulmonary hypertension. In: Shure D, Auger W, Moser K, et al,
editors. Cardiac catheterization: methods, diagnosis, and therapy. Philadelphia: W.B. Saunders; 1977. p. 405; with
permission).
between the superior segmental artery and the
artery to the middle lobe.
Pulmonary angiography: interpretation in the
patient with pulmonary hypertension
Pulmonary angiography of the patient withpulmonary hypertension plays a central role in
delineating the precapillary cause of elevatedpulmonary pressures. Distinguishing major-vesselfrom small-vessel disease allows the correct ther-
apeutic approach to be determined.Auger et al [26] described the angiographic
patterns seen in patients with chronic thrombo-
embolic disease. These patterns include pouchingabnormalities, vascular webs or bandlike constric-tions, intimal irregularities, abrupt narrowing of
major pulmonary vessels, and obstruction of
major pulmonary vessels, most commonly atpoints of origin (Figs. 4–8).
Although pulmonary arterial webs are typical-
ly seen in patients with chronic thromboemboli,they are also seen in congenital stenotic lesions ofthe pulmonary vessels and with vasculitides such
as Takayasu’s arteritis [27,28]. Patients withcongenital stenotic lesions of the pulmonaryvasculature present at an early age and typicallyhave coexisting cardiac abnormalities. Most
Takayasu patients with pulmonary vessel involve-ment demonstrate systemic manifestations.
Total obstruction or abrupt narrowing of the
pulmonary vessel, typically seen in chronic throm-boemboli, can also be seen in extrinsic compressionfrom extensive mediastinal or hilar lympha-
denopathy, fibrosing mediastinitis, and pulmonary
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407P. Guillinta et al / Cardiol Clin 22 (2004) 401–415
Fig. 4. (A) The anteroposterior view of the right pulmonary artery in a patient with CTEPH. Note the marked
hypovascularity, irregularity of the main descending pulmonary artery, and complete occlusion of most segmental
branches. (B) The lateral view of the artery shown in 4A. Note the separation of the right middle lobe branches from the
right lower lobe segments. In this view the middle lobe is perfused, as is the superior segment.
vascular or primary lung malignancies [29–32].Chest CT aids in making the distinguishing theseentities from chronic thromboembolic disease.
Occasionally, several vascular abnormalities
occur in the same patient. In this scenario, thepulmonary angiogram may aid in identifying the
Fig. 5. Right pulmonary angiogram shows central
pulmonary artery enlargement and pouching abnormal-
ity in the right lower lobe vessel seen in chronic thrombo-
embolic disease.
patient with acute on chronic thromboem-bolic disease (Fig. 9). Sharply defined luminaldefects are seen in small, acute emboli. Proximalpulmonary artery enlargement and bandlike
abnormalities are typically seen in chronic throm-boembolic disease but not in acute embolicdisease.
The hemodynamic data can also assist indistinguishing chronic from acute embolism. Pul-monary hypertension with mean PAPs above 35
mm Hg suggest chronicity, because the rightventricle in acute pulmonary embolism withoutprevious pulmonary hypertension is incapable ofgenerating such high pulmonary pressures [33].
The classic angiographic findings in patientswith PPH include normal or dilated centralarteries with pruning of the small, more distal,
nonelastic arteries [8]. Pruning of the pulmonaryvessels may also be seen with chronic thrombo-embolic disease, but in this scenario pruning is
regional and more proximal [34].A key question that the pulmonary angiogram
addresses in patients with suspected CTEPH is the
extent and surgical accessibility of chronic clot.The presence of bilateral disease and proximalinvolvement (main pulmonary trunks, lobar ar-teries, and segmental arteries) predicts surgical
accessibility. Correlation with findings on theperfusion scan is essential, because the presence
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408 P. Guillinta et al / Cardiol Clin 22 (2004) 401–415
Fig. 6. (A) Anteroposterior view of the right pulmonary artery demonstrating hypoperfusion of the lower lobe. (B) Only
on the lateral film does the extent of occlusion of the posterior basal segment and narrowing of the middle lobe branch
become evident. The superior segment is also subtotally occluded.
of segmental defects is predictive of surgical
success (see articles in this issue by Auger et aland Thistlethwaite et al).
Pulmonary angioscopy
When there is significant proximal disease (eg,
complete occlusions of lobar vessels), the inter-
Fig. 7. Abrupt narrowing of the pulmonary vessel seen
in chronic thromboembolic disease.
pretation of pulmonary angiograms is straightfor-
ward. In the UCSD experience the pulmonaryangiogram is suggestive but not definitive in about20% to 25% of cases. The recanalization of
chronic clot allows contrast to permeate throughthe lesions, and the pulmonary angiogram canunderestimate disease just as the perfusion scancan. In addition, the presence of defects at the
Fig. 8. Anteroposterior projection shows complete ob-
struction of the right main pulmonary artery.
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409P. Guillinta et al / Cardiol Clin 22 (2004) 401–415
transition between segmental and subsegmental
vessels may raise doubt regarding the surgicalaccessibility. In the patient with markedly elevatedpulmonary hypertension (pulmonary vascular re-
sistance >800 dynes/second/cm�5) surgical risksrise significantly if insignificant clot is removedduring surgery, leaving the patient with severepulmonary hypertension.
Fiberoptic angioscopy, developed to allow di-rect visualization of the interior of the centralpulmonary vessels up to the segmental and sub-
Fig. 9. Anteroposterior view demonstrates acute on
chronic thromboemboli. Note the distinct numerous
luminal filling defects (solid arrow) in a bandlike or web
abnormality.
segmental levels, is used to define surgical acces-sibility better in borderline cases [35,36]. Thechallenges entailed in performing pulmonary an-gioscopy include the need to maneuver through an
often hypertrophied right ventricle, the widevariation in pulmonary vessel size with varyinganatomic branching, the large number of
branches that require visualization, and the robustcollateral circulation from the bronchial circula-tion. At UCSD pulmonary angioscopy has pro-
gressed through several stages of developmentover the past 20 years. The approach has beento use a balloon system to occlude blood flow
completely in the vessel that is being visualized,rather than a flushing (hemodilution) approach ashas been used in the coronary circulation. Hemo-dilution is not practicable in the large pulmonary
arteries and would entail dangerous fluid overloadin these patients with right-heart failure.
The angioscope presently used is a 120-cm
fiberoptic device, 3 mm in diameter (Figs. 10 and11). It can be flexed 90( at the tip allowing navi-gation through the pulmonary tree. The occluding
balloon is attached at a modified spool-like stain-less steel lip, which allows secure tying of thedisposable balloons. The balloon at the distal end
is inflated with carbon dioxide to protect from airembolism in case of balloon rupture, a precautionof particular importance given the elevated right-sided pressures with potential for right- to-left
embolism in patients with patent foramen ovale.The balloon is connected to a syringe by a tube inthe angioscope, allowing deflation during the
advancement of the catheter and inflation toocclude the vessel as well as allow flotation furtherdownstream.
Fig. 10. The pulmonary angioscope. (Courtesy of Olympus Corporation, Lake Success, NY.)
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410 P. Guillinta et al / Cardiol Clin 22 (2004) 401–415
Because of the size of the angioscope (3 mm) an11-F sheath is used. Although angioscopy can beaccomplished from the femoral approach, it is
much easier to navigate the instrument through theright ventricle using the internal jugular veinapproach, particularly from the right. Two oper-
ators are needed to guide the angioscope, with oneadvancing and torquing the instrument and theother flexing and extending it using the built-in
deflectors. Angioscopy is most helpful in definingthe starting point of chronic thrombi and establish-ing whether they are within surgical reach. Thisprocedure enables the examiner to determine
operability of patients with chronic pulmonarythromboemboli in approximately 75% of the caseswhen the findings on the pulmonary angiogram are
questionable [34]. A detailed map of the majorpulmonary vessels can be performed safely within20 minutes, without significant morbidity, in this
patient population. The main complications en-countered have been transient ventricular ectopyduring transit in the ventricle and minor local
bleeding from the 11-F sheath site in the neck.During the procedure the fluoroscopy images
are recorded to localize the lesions seen onangioscopy and are correlated with the anatomy
as defined in the pulmonary angiogram. Normalpulmonary findings are of smooth, pale white,glistening intima (Fig. 12). Bifurcations are typi-
cally round and regular in appearance. In patientswith pulmonary hypertension, either primaryarterial hypertension or secondary to CTEPH,
the arterial walls may demonstrate small, yellow-ish atheroscleroticlike plaques as well as morediffuse yellowish colorations (Figs. 13 and 14).
Patients with chronic thrombi have irregularpulmonary arterial walls with transluminal bands
Fig. 11. Inflated balloon attached to the distal tip of the
angioscope.
and obstructive lesions and irregular vessel ostia.Thin membranes can also be visualized. At times
reddish-purplish subacute thrombi can be seen,which are distinct from the white fibrotic lesionsof chronic organized and recanalized clot.
Small-vessel arteriopathy in patients with chronicthromboembolic pulmonary hypertension
Although the main site of vasculopathy and
increased resistance in CTEPH is in the large,elastic pulmonary arteries, a significant number ofpatients have concomitant small-vessel arterio-
pathy that may persist despite the removal ofproximal clot. These patients are at increased riskof persistent pulmonary hypertension after pul-monary thrombendarterectomy. Severe persistent
pulmonary hypertension after surgery accountsfor more than one third of perioperative mortalityand up to 50% of long-term deaths. Recently the
pulmonary artery occlusion technique [37] hasbeen used to attempt to partition the pulmonaryresistance into an upstream component (Rup) and
downstream (small arterial plus venous) compo-nent. Using a standard Swan-Ganz catheter (Ed-wards Lifesciences Corporation, Irvine, CA) thepulmonary pressure signal is filtered using a two-
pole digital low-pass filter with a cutoff at 18 Hz.A biexponential fitting of the pressure decay curveis then performed, which allows estimation of the
derived occlusion pressure (Poccl). Rup is thencalculated as follows:
Rup
ð%Þ ¼ mean pulmonary artery pressure� Poccl
mean pulmonary artery pressure� Ppao
where Ppao is the final pulmonary artery oc-cluded pressure (wedge pressure). In patients with
Fig. 12. Normal bifurcation of a pulmonary artery.
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411P. Guillinta et al / Cardiol Clin 22 (2004) 401–415
Fig. 14. Angioscopic findings in CTEPH. Note the yellow plaque prominent in B, G, and K. Membranes, webs, and
masslike fibrotic tissue can be seen.
Fig. 13. Angioscopic findings in CTEPH. Note the fibrotic white material with membranes, webs, and pitting.
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412 P. Guillinta et al / Cardiol Clin 22 (2004) 401–415
Fig. 15. Pulmonary artery pressure occlusion waveforms from two patients with (A) mainly upstream resistance and (B)
mainly downstream resistance. In A the pressure drops more rapidly with balloon occlusion, resulting in lower Poccl and
higher Rup%.
small-vessel arteriopathy the Poccl pressure ishigher (a longer time is required for the pressure
to reach Ppao), and therefore the Rup % is lower(Fig. 15). In a study [37] of 26 patients withsuspected CTEPH, there was an excellent corre-
lation between Rup % before pulmonary throm-bendarterectomy and hemodynamic response tosurgery. Moreover, all four patients with Rup %
below 60 did not survive surgery (Fig. 16).
Coronary arteriography
Before pulmonary thrombendarterectomy the
authors routinely perform coronary arteriographyon all male patients above the age of 40 andfemale patients above the age of 45 and do so for
younger patients if findings are suggestive ofcoronary disease. In the presence of markedly
enlarged proximal pulmonary arteries, the leftmain pulmonary artery may become compressedand give the appearance of ostial left main
stenosis [38]. Best visualized in the let anterioroblique cranial view (Fig. 17), this finding isusually devoid of other evidence of atherosclerosis
and is not in itself an indication for bypasssurgery, especially if the patient’s pulmonarypressures decrease after surgery.
Summary
Cardiac catheterization of the patient withpulmonary hypertension plays an integral part in
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413P. Guillinta et al / Cardiol Clin 22 (2004) 401–415
Fig. 16. Correlation between preoperative Rup % and postoperative outcomes. (A) Postoperative pulmonary resistance
(B) Mean postoperative pulmonary pressure. (Reproduced from Kim NH, Fesler P, Channick RN, et al. Preoperative
pulmonary partitioning of pulmonary vascular resistance correlates with early outcome after thromboendarterectomy
for chronic thromboembolic pulmonary hypertension circulation. 2004;109:19; with permission.)
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414 P. Guillinta et al / Cardiol Clin 22 (2004) 401–415
the diagnostic evaluation. Right-heart hemody-namics, pulmonary angiography, and pulmonaryangioscopy offer a way to determine the cause of
disease safely and accurately and to offer poten-tially life-saving therapies.
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