Imaging

E1087

JACC March 27, 2012

Volume 59, Issue 13

CARDIAC MAGNETIC RESONANCE IMAGING ASSESSMENT OF DIASTOLIC FUNCTION IN

CARDIOMYOPATHIC STATES IN COMPARISON TO HEALTHY SUBJECTS AS ASSESSED BY A NOVEL

FEATURE TRACKING METHOD

ACC Moderated Poster ContributionsMcCormick Place South, Hall A

Saturday, March 24, 2012, 9:30 a.m.-10:30 a.m.

Session Title: Imaging: MRI Applications in Diastology, Pulmonary Hypertension and Congenital Heart DiseaseAbstract Category: 21. Imaging: MRI

Presentation Number: 1088-90

Authors: Deepu Alexander, Kanna Posina, Esosa Odigie-Okon, Nabil Shafi, Kathleen Bertman, Lynette Duncanson, Rena Toole, Simcha Pollack,

Madhavi Kadiyala, Saint Francis Hospital, Roslyn, NY, USA, Stonybrook University, Stonybrook, NY, USA

Background: Diastolic function is difficult to assess using cardiac magnetic resonance imaging (MRI) and is not routinely assessed in practice.

Feature Tracking (FT-MRI) is a novel tissue tracking method, which can be easily used to derive myocardial velocity from standard cine images. We

evaluated the feasibility of evaluating diastolic function in various cardiomyopathic states by FT-MRI.

Methods: Cardiac MRI was performed in 57 carefully screened healthy volunteers, 18 amyloid, 40 dilated, 21 hypertrophic, 42 ischemic

cardiomyopathic and 34 infarction patients. Endocardial borders were semi automatically traced on standard short axis cine MRI images. FT-MRI

(Diogenes MRI, Tomtec Systems) was used to determine early and late diastolic radial velocity in the basal and mid short axis levels.

Results: Diastolic radial velocities measured by FT-MRI were significantly different in the various cardiomyopathic states compared to normal

healthy volunteers (fig1). The basal early diastolic velocity was lower in all cardiomyopathic states except in hypertrophic subjects. Mid early diastolic

radial velocity (e’rr-mid) was the best parameter to differentiate normals from the abnormals by multivariate regression analysis ( R2-0.3, P <0.001).

Conclusion: FT-MRI allows for evaluation of diastolic function in both normal and abnormal states by reliably measuring diastolic tissue velocities

on standard cine MRI images. Mid ventricular early diastolic radial velocity may have potential for clinical use.