cardiolab etfa 2009 v1

8/18/2019 CardioLab ETFA 2009 v1

1/18

CardioLab

ContentContent IntroductionIntroduction ObjectivesObjectives Cardiov. SystemCardiov. System Virtual Lab.Virtual Lab. ConclusionsConclusions

CARDIOLAB: A VIRTAL LABORATOR! "OR T#$CARDIOLAB: A VIRTAL LABORATOR! "OR T#$

A%AL!SIS O" #&A% CIRCLATOR! S!ST$&A%AL!SIS O" #&A% CIRCLATOR! S!ST$&Al'er &auricio #ernande(Al'er &auricio #ernande())* +ino ,ier-ranco #errera* +ino ,ier-ranco #errera))* &iuel Anel &a/anas* &iuel Anel &a/anas00* Ramon* Ramon

Costa1Castell2Costa1Castell233

) Bioelectronics and Clinical $nineerin Researc' 4+IBIC5* niversidad de Antio6uia 4deA5* Colombia0 De7artment o- Automatic Control 4$SAII5* Biomedical $nineerin Researc' Center 4CR$B5

3

Institute o- Industrial and Control $nineerin 4IOC5* niversitat ,olit8ecnica de Catalunya 4,C5* S7ain

I O C I ns ti t ute o- Ind ust r i a l and C o nt r ol $ nine er in

+IBIC Bioelectronic and Clinical $nineerin


2/18

CardioLab


I.I. IntroductionIntroductionII.II. ObjectivesObjectives

III.III. T'e Cardiovascular SystemT'e Cardiovascular System

• &odel descri7tion&odel descri7tion

• Cardiovascular stimuliCardiovascular stimuli

IV.IV. Virtual Lab Descri7tionVirtual Lab Descri7tion • Tool develo7mentTool develo7ment

• Interactive elementsInteractive elements

• ,lots and e9am7les,lots and e9am7les

V.V. ConclusionsConclusions

C o n t e n t

ObjectivesObjectives Cardiov. SystemCardiov. System Virtual Lab.Virtual Lab. ConclusionsConclusions


3/18

CardioLab


Christian Darkin / Science Photo Library ®

I n

t r o d u c t i o n

Biomedical $nineerin 4B&$5 is t'e a77lication o-

enineerin sciences and tec'noloy to medicine and

bioloy. T'e interdisci7linary nature o- t'is activity im7lies

inter7lay and overla77in o- interest and e--ort beteen

enineerin and bioloic 7oints o- vie.

$nineers do not need a dee7 ;nolede o- certain medicalto7ics 4and vice versa5.

B&$ is di--erent to ot'er enineerin

areas in t'e sense o- obtainin

results -rom e97erimental 7rocedures and re7roducin real 7'ysioloical

situations.


4/18

CardioLab


I n

t r o d u c t i o n

It is very di--icult and e97ensive to interact it' t'e 'uman

bein body and even

danerous in certain situations.

T'e -ield o- B&$ includes many career areas* and one o-

t'em is t'e a77lication o- enineerin system analysis

47'ysioloic modelin* simulation* and control5 to bioloic

7roblems.

T'e Autonomic %ervous system

interacts it' t'e cardiovascular

system in order to control t'e

'eart rate and -orce o- 'eart

contraction* constriction and

dilatation o- blood vessels.

BSIP, VILLAREAL/ Science Photo Library ®

Roger Harris/Science Photo Library ®


5/18

CardioLab


O b j e c t i v

e s

• Develo7in a virtual laboratory to study t'ecardiovascular system and t'e e--ect o- stimuli

a77lied to t'e autonomic nerve system.

• ,ro7osin t'e use o- Virtual Labs in t'e study

o- cardiovascular system in B&$ 7rorams* in

order to overcome t'e drabac;s o- interaction

it' 'uman body.

• Desinin a Virtual Lab in a visually attractive

and interactive ay.


6/18

CardioLab


T ' e C a r d

i o v a s c u l a

r S y s t e m

). &odel Descri7tion 4I5). &odel Descri

7tion 4I5

T'e cardiovascular system is structured in di--erent intermediate 7rocesses:

rsino ? and Cavalcanti and Belardinelli


7/18

CardioLab


T'e central autonomic control determines t'e total 1sym7at'etic*

-tas* 1sym7at'etic* -tbs* and 7arasym7at'etic* -t7* in-luences on 'eart

rate and 7eri7'eral resistance -rom t'e barore-le9es* c'emore-le9es

and lun stretc' rece7tors re-le9es.

). &odel Descri7tion 4II5). &odel Descri7tion 4II5

T ' e C a r d

i o v a s c u l a

r S y s t e m

Autonomic control

a--erent sinals* -tas*

-tbs and -t7 allo

simulation o- di--erent

stimuli related it' t'e

sym7at'etic and

7arasym7at'etic

systems.


8/18

CardioLab


Sino Auricular %ode 4S.A.5 translates c'anes in 1sym7at'etic* and

7arasym7at'etic* e--erent activity into c'anes in #eart ,eriod 4#,5:

). &odel Descri7tion 4III5). &odel Descri7tion 4III5

T ' e C a r d

i o v a s c u l a

r S y s t e m

0.58s


9/18

CardioLab


T'e 1sym7at'etic nerves control t'e 7eri7'eral vascular activities.

Durin 'y7otension or 'y7ertension* vasoconstriction or

vasodilatation occurs to 7revent -urt'er decreasin or increasin in

t'e blood 7ressure.

). &odel Descri7tion 4IV5). &odel Descri7tion 4IV5

T ' e C a r d

i o v a s c u l a

r S y s t e m

T'is subsystem is modeled

usin a -irst1order dynamic

system:


10/18

CardioLab


T'e stro;e volume and t'e 'eart 7eriod determine t'e cardiac out7ut4CO5 'ereas arterial blood 7ressure 4ab75 is modulated by t'e

vasculature and cardiac out7ut.

T'e model determines ab7 by means o- t'e -olloin e97ression:

). &odel Descri7tion 4V5). &odel Descri7tion 4V5

T ' e C a r d

i o v a s c u l a

r S y s t e m

'ere Cart re7resents t'e

Arterial Com7liance and RT,R

t'e Total ,eri7'eral

Resistance.

T'e stro;e volume 4SV5is determined by t'e

venous return 4Vn5* t'e

'eart 7eriod and t'e

'eart contractility 4Cn5


11/18

CardioLab


). Cardiovascular Stimuli 4I5). Cardiovascular Stimuli 4I5

$9ercise: #eart rate 4#R5 and stro;e volume 4SV 5 increase durin

e9ercise* 'ic' 7roduces an increase in cardiac out7ut.

C'olineric into9ication: ,roduces one increase o- 7arasym7at'etic

activity and 7roduces also an increase o- t'e cardiac 7eriod and

'y7otension.

Ca--eine: ant'ines suc' as ca--eine and t'eo7'ylline bloc;

adenosine rece7tors increasin t'e activity t'at 7roduces

vasoconstriction* 'i'er 'eart rate and increased 'eart contraction

-orce.

#emorr'ae: An acute blood volume loss 4)EF o- total or more5*

modi-ies t'e systemic arterial 7ressure* cardiac out7ut and total

systemic resistance.

,anic: T'e autonomic system sitc'ed to an alert situation

c'aracteri(ed by 'i'er and sym7at'etic activity.

Almost every 7rocess t'at a--ects t'e autonomic control system also

a--ects t'e cardiovascular system t'rou' t'e vaal and sym7at'etic

activity. "ive stimuli are considered in Cardiolab:

T ' e C a r d

i o v a s c u l a

r S y s t e m


12/18

CardioLab


V i r t u a l

L a b

D e s

c r i 7 t i o n

). Tool Develo7ment). Tool Develo7ment

,resented so-tare,resented so-tare a77licationa77lication is based on $asy Gavais based on $asy Gava

Simulations 4$GS5*Simulations 4$GS5* anan o7en sourceo7en source java1based tool t'at java1based tool t'at allosallos

creatincreatin interactiveinteractive dynamic simulations.dynamic simulations.

SI&LI%HSI&LI%H

&odel 4rsino et al.* )==>5

$AS! GAVA$AS! GAVA

• T'e model is based on

&ATLABSimulin;J.

• T'e simulation runs in

Simulin; 'ile is controlled

by $asy Gava.

• T'e inter-ace to t'e user 'as

been desined and

im7lemented in $GS.


13/18

CardioLab


V i r t u a l

L a b

D e s

c r i 7 t i o n

0. Interactive $lements 4I50. Interactive $lements 4I5

In t'e interactive moduleIn t'e interactive module 7arameters can be c'aned by means7arameters can be c'aned by meanso-o- sliderssliders andand tabstabs in order toin order to simulate di--erent ventilatorysimulate di--erent ventilatory

conditions.conditions.

AA multisinal sco7emultisinal sco7e can be seen 'en t'is o7tion iscan be seen 'en t'is o7tion is selectedselected byby

t'et'e user user ..


14/18

CardioLab


V i r t u a l

L a b

D e s

c r i 7 t i o n

0. Interactive $lements 4II50. Interactive $lements 4II5

"rom

Autonomic

Control


15/18

CardioLab


V i r t u a l

L a b

D e s

c r i 7 t i o n

3. ,lots and $9am7les 4I53. ,lots and $9am7les 4I5

One o- t'eOne o- t'e to ;inds o- 7lotsto ;inds o- 7lots are s'onare s'on 'en'en t'et'e corres7ondin tabcorres7ondin tab o-o-sinal sco7esinal sco7e is selected by t'e user:is selected by t'e user:

A c'ane -romA c'ane -rom normal conditions 4To9icity Level K Em5normal conditions 4To9icity Level K Em5 to a s7eci-icto a s7eci-ic

amount o-amount o- 7esticides in contact it' t'e 'uman7esticides in contact it' t'e 'uman body 4To9icity Level Kbody 4To9icity Level K

m5 is 7roducedm5 is 7roduced at @E secondsat @E seconds in order to simulate ain order to simulate a c'olinericc'olinericinto9ication.into9ication.


16/18

CardioLab


V i r t u a l

L a b

D e s

c r i 7 t i o n

3. ,lots and $9am7les 4II53. ,lots and $9am7les 4II5

A-ter c'olineric into9ication beins*A-ter c'olineric into9ication beins* blood 7ressure and cardiac out7utblood 7ressure and cardiac out7utremain in a li'tly loer valueremain in a li'tly loer value 4see t'e -iure on t'e ri't5.4see t'e -iure on t'e ri't5.

In order to simulate t'e treatmentIn order to simulate t'e treatment o- t'is into9ication*o- t'is into9ication* a second stimulusa second stimulus

is a77lied at )>Es:is a77lied at )>Es: t'e concentration o-t'e concentration o- 7esticides K E7esticides K E and t'eand t'e ain o- t'eain o- t'e

7arasym7at'etic system7arasym7at'etic system is eliminated in order tois eliminated in order to 7roduce a bloc;ade7roduce a bloc;ade4ain K E54ain K E5 related it' t'erelated it' t'e Atro7ineAtro7ine administration.administration.

di b


17/18

CardioLab


V i r t u a l

L a b

D e s

c r i 7 t i o n

M. Cardiolab DemoM. Cardiolab Demo

C di L b


18/18

CardioLab


C o

n c l u s i o

n s

• T'is laboratory is com7letelyT'is laboratory is com7letely ra7'ic and interactive*ra7'ic and interactive* so itso it cancan

be usedbe used to illustrateto illustrate t'e be'avior o- 'uman cardiovasculart'e be'avior o- 'uman cardiovascular

systemsystem under certain stimuliunder certain stimuli..

• CardioLabCardioLab allos t'e students and researc'ersallos t'e students and researc'ers obtainobtain

sensations and e97eriencesensations and e97erience t'att'at ould be very di--icultould be very di--icult

ot'erise because o- t'eot'erise because o- t'e di--iculties in 7er-ormindi--iculties in 7er-ormin

e97erimental 'uman studies.e97erimental 'uman studies.

• T'e useT'e use o- virtual laboratories and interactivity ino- virtual laboratories and interactivity in B&$B&$ 'as'as

7roved to be an7roved to be an e--icient ay to s'ortcute--icient ay to s'ortcut t'et'e learnin 7rocesslearnin 7rocess

an im7rove t'e students ca7abilities.an im7rove t'e students ca7abilities.

• T'e toolT'e tool 'as been built combinin'as been built combinin &ATLABSimulin;&ATLABSimulin; andand $GS.$GS.

'ile'ile &ATLABSimulin;&ATLABSimulin; allos to im7lementallos to im7lement com7le9 modelscom7le9 models

in strai't-orard manner*in strai't-orard manner* $GS allos to desin attractive$GS allos to desin attractive

viesvies andand introduce interactivity easily.introduce interactivity easily.

cardiolab etfa 2009 v1

Documents