cardiosense3d introduction h. delingette
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CardioSense3D Introduction H. Delingette. Intermediate Evaluation of the CardioSense3D Research Action. Agenda of the day. Introduction to CardioSense3D. Scientific Objectives and Positioning Partnership and organization. What is CardioSense3D ?. - PowerPoint PPT PresentationTRANSCRIPT
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CardioSense3DIntroduction
H. Delingette
Intermediate Evaluation of the CardioSense3D Research Action
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Agenda of the day
Start End Topic Speaker
9h30 9h55 Introduction of CardioSense3D ( with 5mn questions) Hervé Delingette
9h55 10h25Research Activity of the Asclepios Team within CardioSense3D
( with 5mn questions)Hervé Delingette
Maxime Sermesant
10h25 10h55Research Activity of the Sisyphe Team within CardioSense3D
( with 5mn questions)Michel Sorine
10h55 11h10 Coffee Break
11h10 11h40Research Activity of the Macs Team within CardioSense3D
( with 5mn questions)Dominique Chapelle
11h40 12h10Research Activity of the Reo Team within CardioSense3D
( with 5mn questions)Jean-Frédéric
Gerbeau
12h10 12h30 Perspectives of CardioSense3D ( with 5mn questions) Miguel Fernandez
12h30 13h45 Lunch Break
13h45 16h00 Discussion with the evaluation committee All
16h00 17h00 Discussion within the evaluation committee
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Introduction to CardioSense3D
•Scientific Objectives and Positioning
•Partnership and organization
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What is CardioSense3D ?
An INRIA Large Initiative Action on cardiac modeling :
• Started (officially) in May 2005
• 4 ans duration (evaluated after 2 years)
• Transversal to 4 INRIA project teams :
– ASCLEPIOS (Medical Image Analysis and Simulation) N. Ayache
– MACS (Biomechanics and Numerical Analysis) : D. Chapelle
– REO (Fluid Mechanics) : J-F. Gerbeau
– SISYPHE (Contrôle and Modeling) : M. Sorine
• Supervisor : H. Delingette,
• Co-Supervisor : M. Fernandez
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Cardiac data
solid mechanics
Clinical applications
Diagnosis
Therapy planning
blood flowPersonalization
electro-physiology
perfusion & metabolism
CardioSense3D Research Topics
Cardiac modeling
anatomy
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Objectives
• Build a patient specific heart simulator
• Estimate the parameters of this model from observations of the
cardiac function,
• Develop clinical applications (Cardiac Resynchronisation
Therapy, radiofrequency ablation,..).
Propose models having a low number of parameters
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State of the art
Computational Cardiac Models
• ElectroPhysiology : Noble et al. (Oxford),
S. Panfilov et al. , O. Dössel (Karlsruhe),
Y. Rudy et al. (Wash. Univ. St Louis),
Colli-Franzone (Univ. Pavia)
• Flow-Biomechanics : C. Peskin (NYU),
Quarteroni (EPFL),…
• Electro-mechanics : Peter Hunter et al.
(Physiome project; Auckland); Andrew
McCulloch et al. (UCSD)
anatomy
electro-physiology
solid mechanicsblood flow
perfusion & metabolism
Cardiac modeling
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State of the art
Cardiac Image Analysis (Geometrical approaches)
• Elliott McVeigh et al. (JHU+NIH)
• D. Rueckert et al. (Imperial College) and R. Razavi et al.
(KCL + Guy’s hospital)
• Magnin et al (Creatis), Duncan et al (Yale), Axel and Metaxas
(Rutgers & NYU), Frangi et al. (Univ. Pompeu Fabra), P. Shi
(Hongkong Univ.)
Cardiac data
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State of the art
Therapy planning
Clinical applications
Diagnosis
Therapy planning (Generic Models)• D. Noble (Oxford)
• A. Mc Culloch (UCSD)
• O. Dössel (U. Karlsruhe) & F. Sasche (U. Utah)
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Positioning of CardioSense3D
•Integrate/Couple 4 physiological phenomena :Electrophysiology, Contraction/Relaxation Mechanics,
Arterial Circulation, Perfusion
•To propose models having a low number of parameters in order to estimate them from clinical data.
•Develop clinical applications (CRT, RF Ablation) based on personalized models
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CardioSense3D : Academic / Clinical / Industrial Partnership
Physiology/Control• Sisyphe/Sosso, INRIA
Numerical Analysis • Macs, INRIA
• Reo, INRIA
• Geometrica, INRIA
• Gamma, INRIA
• Univ. de Nantes
• Pzlen Univ. (Czech Rep.)
• LIRMM (Montpellier)
Imaging/Simulation• Asclepios, INRIA
• UCL / King’s College (London)
• Creatis, CNRS
Clinical Sites• Guy’s Hospital (London)
• NIH (Washington)
• HEGP, U678 (Paris)
• Hopital Henri Mondor (Créteil)
• Sunnybrook Health Sciences Center
• InParys, Clinique George Bizet
• Hopital Bicêtre + Paris XI U. +INSERM (Paris)
Industrial Partners• Philips Research France
• ELA Medical
• (Siemens)
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First Circle Members of CS3DTeam ASCLEPIOS Team MACS Team SOSSO2 Team REO
N. Ayache D. Chapelle M. Sorine J-F. Gerbeau H. Delingette P. Moireau Q. Zhang M.A. Fernández M. Sermesant M. Vidrascu Y. Papelier M. ThirietJM. Peyrat J. Sainte-Marie T. M. Laleg I. Vignon-Clémentel F. Billet E. Phe K. Djabella M. Boulakia D. Lepiller R Djafri N. ZemzemiT. Mansi A. Illanes-Manriquez M. AstorinoN. Toussaint C. Grandmont
•Sophia-Antipolis
•Rocquencourt
Two different INRIA Research Units :
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INRIA Support
Recruitment of :
• P. Moireau (Détachement X-Corps des Telecoms) in 2005
• 4 Phd Thesis :
– R. Chabiniok MD (Macs) from Sep. 2007 bourse Cordi
– M. Astorino (Reo) from Janvier. 2007 bourse Cordi
– F. Billet (Asclepios) from Oct 2006
– R. Djafri (Sisyphe) from 2007
• 3 Engineers :
– M. Alba (Macs) 2005-2006 Ingénieur Associé
– E. Phe (Macs-REO) 2006-2008 Ingénieur Associé
– N. Toussaint (Asclepios) : 2006-2008 Ingénieur Associé
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External Support
National Scholarship :• PhD of N. Zemzemi
Philips Medical Systems Paris (Suresnes):• PhD of D. Lepiller (Asclepios)
ELA Medical :• Post-doc of M. Boulakia (Reo) and Post-doc of G. Ebrard
Siemens Corporate Research• PhD of JM Peyrat
European Health eChild• PhD of T. Mansi
European RTN HaeModel• Phd of N. Diniz Dos Santos
Industrial contracts • PhD of M. Laleg and K. Djabella
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Software
Current Development based on 3 software packages :• LifeV (Reo) (www.lifev.org) for CFD and electrophysiology
• OpenFEM (Macs) (www-rocq.inria.fr/OpenFEM/ ) for FEM continuum mechanics
• Mips and MedInria (Asclepios) for medical image analysis + simple models for electrophysiology and soft tissue deformation (migration on SOFA) (www-sop.inria.fr/asclepios/software/MedINRIA/)
Software developed within CardioSense3D :• CardioViz3D (Asclepios)
• Heartlab (Macs)
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Dissemination Activity
• “Digital Heart” DVD (20mn)
Auteurs scientifiques : Dominique Chapelle, Hervé Delingette, Miguel Fernandez, Philippe Moireau,
Maxime Sermesant
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Dissemination Activity
• “Digital Heart” Movie
• Public release of Software (CardioViz3D) and database (DTI atlas)
• Involvements in Conferences (NIH-INRIA workshop)
• General Audience Articles (La Recherche, Ercim News)
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Dissemination Activity
• “Digital Heart” DVD
• Public release of Software (CardioViz3D) and database (DTI atlas)
• Involvements in Conferences (ISBI’07, NIH-INRIA workshop)
• General Audience Articles (La Recherche, Ercim News)
• CardioSense3D seminars with Paris V university
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Dissemination Activity
• “Digital Heart” DVD
• Public release of Software (CardioViz3D) and database (DTI atlas)
• Involvements in Conferences (ISBI’07, NIH-INRIA workshop)
• General Audience Articles (La Recherche, Ercim News)
•CardioSense3D seminars with Paris V university
•Organisation of workshops (summer school) and conferences (FIMH’09 in Nice)
•Apple ARTS Award
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Agenda of the day
Start End Topic Speaker
9h30 9h55 Introduction of CardioSense3D ( with 5mn questions) Hervé Delingette
9h55 10h25Research Activity of the Asclepios Team within CardioSense3D
( with 5mn questions)Hervé Delingette
Maxime Sermesant
10h25 10h55Research Activity of the Sisyphe Team within CardioSense3D
( with 5mn questions)Michel Sorine
10h55 11h10 Coffee Break
11h10 11h40Research Activity of the Macs Team within CardioSense3D
( with 5mn questions)Dominique Chapelle
11h40 12h10Research Activity of the Reo Team within CardioSense3D
( with 5mn questions)Jean-Frédéric
Gerbeau
12h10 12h30 Perspectives of CardioSense3D ( with 5mn questions) Miguel Fernandez
12h30 13h45 Lunch Break
13h45 16h00 Discussion with the evaluation committee All
16h00 17h00 Discussion within the evaluation committee
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Cardiac data
solid mechanics
Clinical applications
Diagnosis
Therapy planning
blood flowPersonalization
electro-physiology
perfusion & metabolism
CardioSense3D Research Topics
Cardiac modeling
anatomy