ccaf overview april 13, 2014 ze’ev ronai, ph.d. scientific director, la jolla deputy director, nci...
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CCAF Overview
April 13, 2014
Ze’ev Ronai, Ph.D.Scientific Director, La Jolla
Deputy Director, NCI Cancer Center
Cancer Center @ Sanford-Burnham Medical Research Institute
Our MISSIONInvent curesDiscover the cause of disease
10-year Strategic Vision 2014-2023
47 of 64 SBMRI faculty are members of the cancer center engaged in cancer research
Combined strength
Therapeutics DiscoveryDiscovery Research
Our COMPETITIVE ADVANTAGE
10-year Strategic Vision 2014-2023
Collaboration
Our CORE VALUE
10-year Strategic Vision 2014-2023
Collaboration extended to include members of the C3
Our VISIONPillar 1 Pillar 2
• Speed the movement of laboratory discoveries into therapeutics discovery
• Small-molecule drug discovery platform will be the engine for accelerating therapeutics discovery
Therapeutics DiscoveryDiscovery Research
• Generation of new knowledge of biology and disease mechanisms
• Increase human-disease relevance of our discovery research
10-year Strategic Vision 2014-2023
Therapeutic Discovery is available for members of the C3
Snapshot of the SBMRI Cancer Center
• 1976 La Jolla Cancer Research Foundation founded by William & Lillian Waterman Fishman in La Jolla, CA
• 1981 becomes an NCI-designated Research Cancer Center.
• One of seven NCI basic Research Cancer Centers
• NCI-Cancer Center faculty are 73% (47/64) of SBMRI faculty
61 post docs, 20 grad students
• Largest-but-one NCI basic science cancer center (faculty and budget) with total annual NCI funding >$20M
• 134 cancer relevant publications per year
SBMRI Cancer Center Mission
The SBMRI Cancer Center will be a national leader in the battle to overcome cancer as a cause of human
suffering and death.
conducting paradigm shifting, multidisciplinary basic research into the causes, prevention and treatment of cancer
rapidly translating our discoveries into the clinic for the benefit of cancer patients everywhere
educating and training the next generation of cancer scientists
Characteristics - SBMRI Cancer Center
• Outstanding high impact science leading to novel therapies
• Largest academic infrastructure for cancer drug discovery
• Addressing timely unmet medical needs
• Located in the second largest biotech cluster in the US
Engaging minority and diverse students in cancer research
Fresno State Program – P20
Preuss High School Program – P30 supplement
SBMRI CC hosts 10 Preuss School rising seniors as summer interns for 6 weeks each summer supervised by CC faculty The objective is to provide mentoring, laboratory skills, and experience in an environment that inspires students to seek an undergraduate major in the biological sciences.
SBMRI CC hosts six Fresno State summer students; who work in three CC laboratories under the supervision of CC faculty. The objective is to recruit promising minority students to doctoral programs in cancer research, preferably at Sanford-Burnham.
SBMRI Cancer Community Advisory Board
Mission
To promote a dynamic exchange of information between the Sanford-Burnham scientific community, patients and their supporters.
• Presentations at Cancer Center Faculty Retreats
• Provide advocacy support for research proposals, as well as involvement in project development.
• Host National Cancer Survivors Day event (6/2014)
• Host on-campus open houses to promote CC research and provide patients, their supporters and the public better insight into the importance of our science
STRIVE Translational Initiative
Goal: To provide advice and support to move SBMRI innovative drug or diagnostic projects to the next level
Bi-monthly meetings attended by faculty, students and representatives from La Jolla’s biotech and pharma community.
Projects
1. Inhibitors of fatty acid synthase as cancer agents* - Dr. Jeff Smith
2. NEDD8 activating enzyme inhibitor for cancer therapy* - Dr. Matt Petroski
3. Targephrin: Drug delivery selectively targeting cancer cells * - Dr. Maurizio Pellecchia
4. Cyclic EphA4 peptide antagonists for cancer stem cells - Dr. Elena Pasquale
*Funded projects (milestone driven) ~ $50 K.
NCI Basic Cancer Centers
Jack-son Lab
Purdue Salk Cold Spring Harbo
Wistar SBMRI MIT0
5
10
15
20
25
Total NCI funding 2013 in $M
CC Faculty 7 87 30 31 30 48 27
Source: NIH Online Research Portfolio 2013
r
Data: Membership and Themes (47 + 8 adjunct)
Program 1 Tumor Initiation and Maintenance
(TIM)
Program 2 Cell Death and Survival Networks
(CDSN)
Program 3 Tumor Microenvironment and Metastasis
(TMEM)
Robert Wechsler--
Reya, PhD
Program Leader
Themes
Stem Cells and Development
Cell Growth Signaling
RNA Biology
Jorge Moscat, PhD
Metabolic and Stress Signaling
Autophagy and Cell Death
Molecular Therapeutics
Sara Courtneidge, PhD
Modulation of Angiogenesis and Immune/Inflammatory
Cell Migration, Invasion and Metastasis
New Intervention Points for
Cancer Therapy
7 members
6 members
3 members
7 members
3 members
8 members
6 members
3 members
Program Leader
Themes
Program Leader
Themes
6 members
Sanford-Burnham Technology InfrastructureComplementing Expertise for the C3 members
Animal ResourcesAnimal Care & ProceduresIn Vivo Imaging & AnalysisTumor AnalysisCardiometabolic PhenotypingModel Organisms
Cell Imaging & AnalysisCell ImagingHistopathology Flow Cytometry
GenomicsDNA AnalysisMicroarray & QPCRHT DNA sequencing
Proteomics & MetabolomicsProteomicsMetabolomicsCancer Metabolism
Structural BiologyCrystallographyNuclear Magnetic ResonanceProtein Production & Analysis
Bioinformatics &Data ManagementBioinformaticsStatistics3D Computational Modeling
Conrad Prebys CenterFor Chemical GenomicsAssay DevelopmentHigh Throughput ScreeningHigh Content ScreeningUltra-HTSCell-Based Disease ModelingCheminformaticsMedicinal ChemistryExploratory Pharmacology
Functional GenomicsRNAi and cDNA screeningViral Vectors
Stem Cells Embryonic Stem Cells iPSCs & Disease Models
SharedResources
Cancer Centers Council 3C
Shared Resources at internal rate +16% 1. Biorepository and Tissue Technology (Moores CC)2. Viral Vectors (Salk Institute)3. High Throughput Screening (SBMRI)
Pedal the Cause to support collaborative translational grants between the three institutions ($0.5M in its first year)
Annual joint scientific retreat highlighting collaborative projects
SBMRI, UCSD Moores, Salk Institute Formally launched June 2013
http://sdcancercouncil.org
Cancer Centers Council 3C
C3 Characteristics & goals:
1. facilitate collaborative cancer research activities between the institutions;
2. leveraging resources, with select shared resources available to all investigators at internal member rates
3. organizing joint public and scientific initiatives
4. facilitating interactions with other research entities in the public and private sector in and around San Diego.
9 inter-institutional projects are currently underway;
2 with The Salk Institute CC and 7 with UCSD.
Extending and enhancing collaborations: >45 joint publications
http://sdcancercouncil.org
SBMRI Cancer Center Access to human tumor tissues*
Agreements with:
• Florida Hospital System, Orlando 1,2,3
pancreas, colon, prostate, breast• University of Colorado, Denver2,3
melanoma• Vancouver Prostate Centre2
prostate• Moores Cancer Center C3, UCSD1,3,4
glioblastoma, medulloblastoma, pancreas, colon, breast, liver• MD Anderson Cancer Center3
colon• Yale University 1,3
lung, melanoma• Molecular Research (La Jolla)4
colon, prostate, breast, lung• Scripps Health System (San Diego)
lung, colon 1,2,3
1fresh tissue, 2TMA, 3PDX mice, 4frozen tissue digest
*Coordinated by the Tissue and Histopathology Shared Resource
C3
CCAF Discussion