cd mortality
DESCRIPTION
presentation i StockholmTRANSCRIPT
![Page 1: Cd Mortality](https://reader033.vdocument.in/reader033/viewer/2022052909/559863791a28abb4128b4627/html5/thumbnails/1.jpg)
KI 2009
Mortality in celiac disease
Jonas F. Ludvigsson
![Page 2: Cd Mortality](https://reader033.vdocument.in/reader033/viewer/2022052909/559863791a28abb4128b4627/html5/thumbnails/2.jpg)
Earlier studies
0
1
2
3
4
Collin Viljamaa West Logan Peters Corrao Solaym. Nielsen CottoneAnderss.Metzger
Celiac Disease Positive Serology
![Page 3: Cd Mortality](https://reader033.vdocument.in/reader033/viewer/2022052909/559863791a28abb4128b4627/html5/thumbnails/3.jpg)
Biopsi
28
![Page 4: Cd Mortality](https://reader033.vdocument.in/reader033/viewer/2022052909/559863791a28abb4128b4627/html5/thumbnails/4.jpg)
CD serology data from 8 university hospitals
Latent CD, Normal mucosa but positiv CD serology
![Page 5: Cd Mortality](https://reader033.vdocument.in/reader033/viewer/2022052909/559863791a28abb4128b4627/html5/thumbnails/5.jpg)
Validation
Questionnaries:1. Gastroenterol.2. Pediatricians3. Pathologists
Interobserver reliability
Patient Chart Reviews
Linkage toCD serology data
![Page 6: Cd Mortality](https://reader033.vdocument.in/reader033/viewer/2022052909/559863791a28abb4128b4627/html5/thumbnails/6.jpg)
Normal Borderline Villous atr.
Normal 74 (96%) 3 0 77
Borderline 12 22 (56%) 5 39
Villous atr. 2 18 190 (90%) 210
Total 88 43 195 326
Interobserver reliability
![Page 7: Cd Mortality](https://reader033.vdocument.in/reader033/viewer/2022052909/559863791a28abb4128b4627/html5/thumbnails/7.jpg)
96%
4%1%
9-10/10 5-8/101-4/10 Never
Adults: 96%
N = 180100%
Children: 100%
N = 68
Biopsy prior to CD diagnosis
![Page 8: Cd Mortality](https://reader033.vdocument.in/reader033/viewer/2022052909/559863791a28abb4128b4627/html5/thumbnails/8.jpg)
Villous atrophy is clinical CD in 95% of cases
95%
5%
CD Not CD
Is villous atrophy equal to CD?
![Page 9: Cd Mortality](https://reader033.vdocument.in/reader033/viewer/2022052909/559863791a28abb4128b4627/html5/thumbnails/9.jpg)
79% of the validated individuals with VA and 64% of those with inflammation had documented gastrointestinal symptoms prior to biopsy.
88% of the validated individuals with VA had positive CD serology before their first biopsy.
Is villous atrophy equal to CD?
![Page 10: Cd Mortality](https://reader033.vdocument.in/reader033/viewer/2022052909/559863791a28abb4128b4627/html5/thumbnails/10.jpg)
3,700 13,400
29,000
![Page 11: Cd Mortality](https://reader033.vdocument.in/reader033/viewer/2022052909/559863791a28abb4128b4627/html5/thumbnails/11.jpg)
Overall mortality
HR 95% CI for HR p-value Number of
deaths
Reference 1.00 1.00 23,633
CD 1.39 (1.33-1.45) 5.42527 E-53 3,049
Inflammation 1.72 (1.64-1.79) 2.7082 E-130 2,967
Latent CD 1.35 (1.14-1.58) 0.00034 183
![Page 12: Cd Mortality](https://reader033.vdocument.in/reader033/viewer/2022052909/559863791a28abb4128b4627/html5/thumbnails/12.jpg)
Subanalyses
Increased mortality:All age groups including children
No difference over calendar periodNo difference between males/females
Low absolute risks
![Page 13: Cd Mortality](https://reader033.vdocument.in/reader033/viewer/2022052909/559863791a28abb4128b4627/html5/thumbnails/13.jpg)
The End