cell biology and signal transductiondepartment of molecular and cell biology 142 life sciences...

42 POSTER SESSIONSPoster board is in bold above the title. See page 15 for presentation schedule. The first author is the presenter.

Full abstracts can be found online at www.drosophila-conf.org

Cell Biology and Signal Transduction

157AA Whole-Genome RNAi Screen for Low-Energy EpithelialPolarity Factors. Daniel T. Bergstralh1, Vincent Mirouse2, DanielSt. Johnston1. 1) Gurdon Institute, University of Cambridge,Cambridge, United Kingdom; 2) Clermont Université, UFRMédecine, Clermont-Ferrand, France.

158BThe transcription factor network patterning outer photoreceptors.Hui-Yi Hsiao, Robert Johnston, Dave Jukam, ClaudeDesplan. Dept Biol, New York Univ, New York, NY.

159CRho1 and multiple wing hairs in wing planar polarity. QiuhengLu, Jie Yan, Paul Adler. Biology Department, Cell BiologyDepartment, Morphogenesis and Regenerative MedicineInstitute and Cancer Center, University of Virginia, Charlottesville,VA 22903.

160ARole of Rab11 in sensory bristle development. RanganayakiNagaraj, Paul Adler. Dept Biol, Univ Virginia, Charlottesville,VA. 22903.

161BControl of apical cell shape remodelling: involvement of ZPproteins during epidermal cell morphogenesis. Serge Plaza1,Isabelle Fernandes1, Helene Chanut1, Yvan Latapie1, PierreFerrer1, Markus Affolter2, Francois Payre1. 1) Centre debiologie du developpement, CNRS UMR5547, Universite PaulSabatier, Toulouse, France; 2) Biozentrum der UniversitätBasel,klingelbergstrasse 70, Basel CH-4056, Switzerland.

162CDetermining how the protein Fat functions in growth and planarcell polarity. Robyn Rosenfeld1,2, Helen McNeill1,2. 1)Department of Molecular Genetics, University of Toronto, Toronto,Ontario, Canada; 2) Samuel Lunenfeld Research Institute, MountSinai Hopsital, Toronto, Ontario, Canada.

163AAnalysis of the Ovarian Follicle Cell Signaling in Drosophila. YiSun1, Elena Domanitskaya1,2, Yan Yan1, Natalie Denef1,2, TrudiSchupbach1,2. 1) Molecular Biology, Princeton Univ, Princeton,NJ; 2) Howard Hughes Medical Institute.

164BPak localized by integrins is required for recruitment of theScribble complex and septate junction formation during dorsalclosure. S. Wang1, S. Bahri2, R. Conder1,3, J. Choy2, S. Vlachos1,X. Yang2, E. Manser2,4, N. Harden1. 1) Department of MolecularBiology and Biochemistry, Simon Fraser University, Burnaby, BC,Canada; 2) Institute of Molecular and Cell Biology, Singapore;3) Institute of Molecular Biotechnology, Vienna, Austria; 4)Institute of Medical Biology, Singapore.

165CA live germline clone screen to identify new genes required forDrosophila anterior-posterior axis formation. T. Zhao, R.Nieuwburg, D. St. Johnston. The Wellcome Trust/ CRUKGurdon Institute, Cambridge, United Kingdom.

166AYuri Gagarin protein regulates F-Actin formation and interactswith the F-Actin stabilizing protein Tropomyosin. Kathleen M.Beckingham1, Michael J. Texada1,2, Rebecca A. Simonette1,William J. Deery1. 1) Dept. of Biochemistry and Cell Biology,Rice University, Houston, TX; 2) HHMI Janelia Farm ResearchCampus.

167BFusion pore expansion during Drosophila myoblast fusiondepends on the Arp2/3 complex. Susanne Berger1, GrittSchäfer1, Anne Holz2, Lothar Beck1, Renate Renkawitz-Pohl1,Susanne Ã-nel1. 1) Philipps-Universität Marburg, Germany; 2)Justus-Liebig-Universität Giessen, Germany.

168CMutations in the conserved actin-binding domain affect β spectrinstability and cause abnormal growth in Drosophila. RonDubreuil, Chris Base, Amlan Das, Chris Fretland. DeptBiological Sci, Univ Illinois at Chicago, Chicago, IL.

169AThe SCAR and WASp nucleation promoting factors actsequentially to mediate myoblast fusion in Drosophila. BoazGildor, R'ada Massarwa, Ben-Zion Shilo, Eyal D. Schejter.Dept. of Mol. Genetics, Weizmann Inst. of Science, Rehovot,Israel.

170BA two-step process of myosin VI localization. Mamiko Isaji1,Tatsuhiko Noguchi2, Kathryn Miller1. 1) Washington universityin St. Louis, Campus box 1137, One Brookings Drive, St. Louis,MO; 2) RIKEN Kobe, 2-2-3 Minatojima-minamimachi Chuo-ku,Kobe 650-0047, JAPAN.

171CSeptate junctions are required for left-right asymmetricdevelopment of the embryonic gut in Drosophila melanogaster.Yasuhiro Kawakatsu, Takashi Okumura, Reo Maeda,Kiichirou Taniguchi, Naotaka Nakazawa, Kenji Matsuno.Department of Biological Science and Technology, TokyoUniversity of Science, Japan.

172APhosphatidylinositol 4,5-bisphosphate signaling regulatessynaptic morphology. T. Khuong, R. Habets, P. Verstreken.Laboratory of Neuronal Communication VIB, Department ofMolecular and Developmental Genetics K.U. Leuven, Center forHuman Genetics, Belgium.

173BDiscs-Large (Dlg) and Strabismus (Stbm)/Van Gogh (Vang)regulate microtubule dynamics and formation. G. Kim1, B.Mukhopadhyay2, O.-K. Lee3, K.-O. Cho1. 1) Dept of BiologicalSciences, KAIST, Daejeon, Korea; 2) Baylor College of Medicine,Houston , TX; 3) Harvard Medical School, Boston, MA.

174CAnkyrin 2-binding activity is required for spectrin function inDrosophila, but spectrin still assembles upstream of ankyrin.Gloria H. Mazock, Amlan Das, Chris Base, Ron Dubreuil.Biological Sciences, University of Illinois, Chicago.

POSTER SESSIONS 43Poster board is in bold above the title. See page 15 for presentation schedule. The first author is the presenter.


175AProteomic analysis of ventral furrow formation. J. Minden, M.Puri, A. Goyal, M. Witzberger. Dept Biological Sci, CarnegieMellon Univ, Pittsburgh, PA.

176BMoesin promotes cell survival through regulation of Rho1localization and activation of JNK signaling. Amanda Neisch,Olga Speck, Richard Fehon. Dept MGCB, Univ Chicago,Chicago, IL.

177CThe PDZ-GEF Dizzy is essential for an efficient formation of theventral furrow. A. Ott, R. Reuter. Div Animal Gen, Univ Tübingen,Tübingen, B-Württemberg, Germany.

178AThe WASp-based actin polymerization machinery is essentialfor spermatid release during the final phase of Drosophilaspermatogenesis. Shay Rotkopf, Ben-Zion Shilo, Eyal D.Schejter. Department of Molecular Genetics, The WeizmannInstitute of Science, Rehovot, Israel.

179BMultiple formins are involved in actin bundle formation indeveloping Drosophila bristles. Kaushik Roychoudhury, KathrynMiller. Biology Dept, Washington University , St. Louis, MO.

180CWASp is required for myoblast fusion during formation of adultDrosophila muscles. Eyal D. Schejter1, Priyankana Mukherjee2,Boaz Gildor1, K. VijayRhagavan2, Ben-Zion Shilo1. 1) DeptMol. Genetics, Weizmann Inst. of Science, Rehovot, Israel; 2)NCBS, Bangalore, India.

181AAbl kinase interacts with Rho1 to regulate cell migration duringDrosophila development. Traci L. Stevens, Nicholas B.Artabazon, Katherine D. Miller. Dept. of Biology, Randolph-Macon College, Ashland, VA.

182BPhosphatidylinositol 4-kinase IIIα is required for plasma membraneintegrity and actin organization during Drosophila oogenesis. JulieTan1, David Hipfner2, Julie Brill1. 1) Dept Dev Stem Cell Biol,Hosp Sick Children, Toronto, ON, Canada; 2) Institut deRecherches Cliniques de Montreal, Montreal QC, Canada.

183CDetermining the biochemical and cellular interaction of Frazzledand Abelson Tyrosine Kinase. Bridget E. Varughese1, MarikaBrezden1, Mark Seeger2, Mark VanBerkum1. 1) BiologicalSciences, Wayne State University, Detroit, MI; 2) The Ohio StateUniversity, Department of Molecular Genetics and Center forMolecular Neurobiology, Columbus, OH.

184AA screen for modifiers of dpak oogenesis defects reveals anantagonistic relationship between Pak and Rho1 signaling. S.Vlachos1, R. Conder2, N. Harden1. 1) Dept. of Molecular BiologyBiochemistry, Simon Fraser Univerisity, 8888 University Drive,Burnaby, British Columbia, V5A 1S6, Canada; 2) Institute ofMolecular Biotechnology of the Austrian Academy of Sciences(IMBA), Dr. Bohr Gasse, A-1030 Vienna, Austria.

185BRho GTPase function in cohesive migration of the embryonicsalivary gland. Na Xu, Monn Myat. Dept Cell Dev Biol, WeillMed Col Cornell, New York, NY.

186CCharacterization of uninflatable, a gene required for trachealinflation. Liang Zhang, Robert Ward. Dept MolecularBiosciences, Univ Kansas, Lawrence, KS.

187ADTestican Regulates the Wing Venation in Drosophila. W.Chiang1,3, Y. Chang1,2, Y. Sun1,2,3. 1) Institute of Molecular Biology,Academia Sinica, Taipei, Taiwan; 2) Graduate Institute of LifeSciences, National Defense Medical Center, Taipei, Taiwan; 3)Department of Life Sciences and Institute of Genome Sciences,National Yang Ming University, Taipei, Taiwan.

188BMechanisms of JNK/AP-1 and Dpp signal antagonism. GregoryB. Humphreys, Kate Monroe, Anthea Letsou. HumanGenetics, University of Utah, Salt Lake City.

189CThe Ras-MAP kinase pathway modulates BMP responses inthe wing. Laurel A. Raftery1, Jing Cao1, Mingfa Li2, Wei Sun1.1) Cutaneous Biol Res Ctr, MGH/Harvard Med School,Charlestown, MA; 2) Shanghai Jiao Tong University, Shanghai,PR China.

190AA mosaic screen to identify novel regulators of BMP signaling inthe developing wing. Justin B. Schleede1,2, Seth Blair1. 1)Zoology Dept., University of Wisconsin, Madison; 2) Laboratoryof Genetics, University of Wisconsin, Madison.

191BNovel targets of BMP signaling during Drosophila wing discdevelopment. Milan Szuperak, Alejandra Figueroa-Clarevega,Juan Du, Matthew McCarther, Emily Meyer, Sally Salah, MattGibson. Stowers Institute for Medical Research, Kansas City,MO.

192CThe Role of Auxilin and Endocytosis in Notch Signaling. Susan M.Banks, Janice A. Fischer. ICMB, Univ Texas, Austin, Austin, TX.

193ANotch down-regulation by endocytosis is essential for pigmentcell determination and survival in the Drosophila retina. J.Vinós1,2, M. A. González-Gaitán3, F. Moya4, S. Peralta2. 1)Instituto de Investigaciones Biomedicas Alberto Sols, CSIC,Madrid, Spain; 2) Departamento de Bioquímica, UniversidadAutónoma de Madrid, Spain; 3) Department of Biochemistry,Sciences II, Université de Genève, Geneva, Switzerland; 4)Instituto de Neurociencias CSIC, San Juan, Alicante, Spain.

194BRequirements for cell surface endocytic regulators in epithelialpolarity and Delta/Notch trafficking and signaling. Sarah L.Windler, David Bilder. University of California, BerkeleyDepartment of Molecular and Cell Biology 142 Life SciencesAddition #3200 Berkeley, CA 94720-3200.



195CCommon and distinct characteristics of ESCRT-II componentsvps22, vps25, and vps36. Sarah Elizabeth Woodfield1,2, Hans-Martin Herz3, Zhihong Chen2, Clare Bolduc2, AndreasBergmann1,2. 1) Graduate Program in Developmental Biology,Baylor College of Medicine, Houston, TX, USA; 2) University ofTexas M.D. Anderson Cancer Center, Houston, TX, USA; 3)Stowers Institute for Medical Research, Kansas City, MO, USA.

196ARegulation of the Hedgehog pathway by the glypican Dally andthe hydrolase Notum. Katie L. Ayers, Armel Gallet, Pascal P.Therond. Centre de Biochimie, IDBC CNRS UMR6543, 06108Nice Cedex2, France.

197BDispatched mediates the baso-lateral release of Hedgehog.Ainhoa Callejo1, Afrodita Bilioni1, Emanuela Mollica1, NicoleGorfinkiel2, Carlos Torroja3, Isabel Guerrero1. 1)Developmental Biology, Centro de Biol Molecular "SeveroOchoa", Madrid, Madrid, Spain; 2) Department of Genetics,University of Cambridge, Cambridge, UK; 3) Sanger InstituteThe Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

198CPP4 and PP2A regulate Hedgehog signaling by controlling Smoand Ci phosphorylation. Hongge Jia, Yajuan Liu, Wei Yan,Jianhang Jia. the Sealy Center for Cancer Cell Biology, UTMB,Galveston, TX.

199AiHog and Dally-like control the secretion, spreading and receptionof Hedgehog. E. Mollica1, A. Bilioni1, L. Doglio2, A. Callejo1, I.Guerrero1. 1) Developmental Biology, Centro de BiologiaMolecular "Severo Ochoa", Cantoblanco- Madrid, Madrid, Spain;2) Centro Nacional de Investigaciones Oncológicas, Madrid,Spain.

200BMechanism of the partial proteolysis of Cubitus interruptus. MaryAnn Price1, Yifei Wang2, Satoshi Hasegawa1. 1) DevelopmentalSignalling Unit, Okinawa Institute of Science and Technology,Uruma City, Okinawa, Japan; 2) Department of BiomedicalScience, University of Sheffield, Sheffield, UK.

201CHedgehog Signaling-Regulated Protein Phosphatase 2ADephosphorylates Smoothened. Ying Su, Jason Ospina,Junzheng Zhang, Andrew Michelson, Adam Schoen, AlanZhu. Dept Cell Biol, Lerner Res Inst, Cleveland, OH.

202AThe amino half of Gint3, a ubiquitin-like protein, binds to rabGDI. Clarissa M. Cheney1, Palak Amin1, Amelia Nordmann1,Simiao Li1, Reed Ayabe1, Malkiat Johal2. 1) Dept Biol, PomonaCol, Claremont, CA; 2) Dept Chem, Pomona Col, Claremont,CA.

203BAcinus is a regulator of autophagic and endocytic trafficking.Adam Haberman, Sanchali Ray, Helmut Kramer. Cntr BasicNeurosci, UT Southwestern Med Cntr, Dallas, TX.

204CActivation of Mob as tumor suppressor by Membrane Associationin Growth Inhibition. Li-Lun Ho1, Zhi-Chun Lai1,2. 1) Departmentof Biology, The Pennsylvania State University, University Park,PA; 2) Department of Biochemistry and Molecular Biology, ThePennsylvania State University, University Park, PA.

205AFunctional analysis of the dp-interactor docked. Suresh KumarKandasamy, Kiley Maguire, Justin Thackeray. BiologyDepartment, Clark University, Worcester, MA.

206BEndocytic recycling precedes γ-secretase-mediated S3 cleavageof Notch receptor in Drosophila. Zhouhua Li, William Chia, YuCai. Germ Cell Development Group, Temasek Life Sciences Lab,Singapore, Singapore.

207CDual roles for the PtdIns 4-kinase Fwd in regulating Rab11localization during cytokinesis. Gordon Polevoy, Ho-Chun Wei,Raymond Wong, Sarah Steinbach, Julie Brill. DevelopmentalStem Cell Biol, Hosp Sick Children, Toronto, ON, Canada.

208AThe Role of Milton Associated Proteins and O-linkedGlycosylation in Mitochondrial Movement in Neurons. GayaniR. Weerasinghe, Dona Love, Rasikapriya Kalamegham, PengWang, Brian Oliver, Michael Krause, John Hanover. NationalInstitute of Diabetes and Digestive and Kidney Disease, NationalInstitutes of Health, Bethesda, MD.

209BControlling bidirectional transport of lipid droplets: Thedirectionality determinant Halo interacts physically with bothKinesin-1 and Dynein. Michael A. Welte, Susan L. Tran. Dept.of Biology, University of Rochester, Rochester, NY.

210CGenetic analysis of CG2774, one possible retromer complexcomponent, in Drosophila. Bo Zhou, Xinhua Lin. Dev Biol,Cincinnati Children's Hosp, Cincinnati, OH.

211AThe functional interaction of JAK/STAT pathway ligands. QianChen, Shanshan Pei, Douglas Harrison. University of Kentucky,Lexington, KY.

212BThe SOCSless fly: A Barefoot genome. D. W. Perry, Q. Guo, S.M. Harrison, D. A. Harrison. Department of Biology, Universityof Kentucky, Lexington, KY.

213CA Role for Ipk2 Kinase Activity in Regulating Cell Proliferationand Apoptosis of Imaginal Disc Tissue During DrosophilaMelanogaster Development. Man-kin Marco Tsui, Andrew M.Seeds, Mandy M. Tin, John York. Dept Pharm Cancer Biol,Duke Univ, Durham, NC.



214ADynamic analyses of Drosophila gastrulation provide insightsinto the role of FGF signaling in collective cell behavior. AmyMcMahon1, Willy Supatto2, Scott E. Fraser2, AngelikeStathopoulos1. 1) Dept Biol, California Inst Tech, Pasadena,CA; 2) Beckman Institute, California Inst Tech, Pasadena, CA.

215BDynamic regulation of septate junction formation duringmorphogenesis. Kenzi Oshima, Richard Fehon. Dpt ofMolecular Genetics and Cell Biology, University of Chicago,Chicago, IL.

216CDomain analysis to dissect the role of the integrin effector PINCH.Maria C. Elias1,2, Julie L. Kadrmas1,2, Mary C. Beckerle1,2,3. 1)Dept. of Oncological Sciences, University of Utah, Salt Lake City;2) Huntsman Cancer Institute, University of Utah, Salt Lake City;3) Dept of Biology, University of Utah, Salt Lake City.

217AIntegrin regulation of filopodia during muscle migration. Y. Inoue,N. H. Brown. The Gurdon Institute and Dept of PDN, Universityof Cambridge, United Kingdom.

218BFGF ligands in Drosophila have distinct activities required tosupport cell migration and differentiation. Snehalata V. Kadam,Amy McMahon, Phoebe Tzou, Sarah Payne, AngelikeStathopoulos. Biology Division, Caltech, Pasadena, CA.

219CIdentification of Amino Acids in the Tre1 G Protein-CoupledReceptor Important for Cell Migration and Programmed CellDeath. Margaret M. Pruitt, Angela R. Kamps, Clark R.Coffman. Iowa State University, Ames, IA.

220ACas genetically interacts with the E-cadherin complex inDrosophila. Nadia Tikhmyanova1,2, Fabrice Roegiers1, AlexeiTulin1, Erica Golemis1. 1) Fox Chase Cancer Center ,Philadelphia, PA; 2) Drexel University, Philadelphia, PA.

221BA genome-wide RNAi screen to identify the genes regulatingvesicular trafficking of Notch in Drosophila melanogaster. N.Aoyama1, H. Okubo1, M. Ohhori1, I. Tamura1, E. Iida1, R. Ueda3,Y. Yamaguchi-Takei2, A. Watanabe2, T. Tabata2, K. Matsuno1.1) Biological Sci Tech, Tokyo Univ Scinece, Noda, Chiba, Japan;2) IMCB. Univ. Tokyo; 3) NIG.

222CA novel role of Notch monosaccharide O-fucose modification isrequired for Delta-Notch but not Serrate-Notch signaling inDrosophila. T. Ayukawa1, H. Ishikawa2, M. Nakayama2, S.Kamiyama3, S. Nishihara3, T. Okajima4, K. Aoki5, N. Ishida5, Y.Sanai5, K. Matsuno1,2. 1) Department of Biological Sciense,Tokyo University of Sciense, Japan; 2) G DRC, Tokyo Universityof Science, Japan; 3) Laboratory of Cell Biology, Department ofBioinformatics, Faculty of Engineering, Soka University, Japan;4) Nagoya University Graduate School of BioagriculturalSciences, Department of Applied Molecular Biosciences, Japan;5) Department of Biochemical Cell Research, The TokyoMetropolitan Institute of Medical Science, Japan.

223AThe role of Notch downstream of the archipelago growthsuppressor gene. Carolyn Krisel Beam, Kenneth H. Moberg.Cell Biology Department, Emory University School of Medicine,Atlanta, GA.

224BContext-specific response upon Notch pathway activation. FredBernard, Ben Housden, Alena Krejci, Sarah Bray. PDN,University of Cambridge, Cambridge, Cambridgeshire, UnitedKingdom.

225CRegulation of Delta signaling by Bearded family members. SolineChanet, Nicolas Vodovar, Francois Schweisguth. InstitutPasteur - CNRS URA 2578, Paris, France.

226ACharacterization of transportin in Notch signaling pathway. Wu-Lin Charng1, An-Chi Tien1, Akhila Rajan2, Karen Schulze3,Hugo J. Bellen1,2,3. 1) Program in Developmental Biology; 2)Department of Molecular and Human Genetics; 3) HHMI, BaylorCollege of Medicine, Houston, TX.

227BRoles of conserved intracellular motifs of the Delta protein.Katerina Daskalaki1,2, Kristina Kux1,2, Christos Delidakis1,2.1) Institute of Molecular Biology and Biotechnology, FORTH,Heraklion, Greece; 2) Department of Biology, University of Crete,Heraklion, Greece.

228CGenetic analysis of the role of Glycosphingolipids in Notchsignaling. Sophie Hamel, François Schweisguth. InstitutPasteur, URA2578 GDD, Paris, France.

229ANotch directly regulates EGFR signalling at multiple levels. BenHousden, Alena Krejci, Fred Bernard, Sarah Bray. Universityof Cambridge, Cambridge, United Kingdom.

230BMolecular and genetic characterization of the Notch signalingnetwork. J.-F. Rual1, J. W. Carlson2, O. Cenaj1, X. Chen2, B.Kapadia2, G. Kuthethur1, J. Mintseris1, A. Noor3, B. Parsa2, V.Reddy3, M. Stapleton2, P. Vaidya1, K. H. Wan2, C. Yu2, B. Zhai1,R. A. Obar1, K. VijayRaghavan3, S. E. Celniker2, S. P. Gygi1, S.Artavanis-Tsakonas1. 1) Department of Cell Biology, HarvardMedical School, Boston, MA; 2) Berkeley Drosophila GenomeProject, Lawrence Berkeley National Laboratory, Berkeley, CA ;3) National Centre for Biological Sciences, Tata Institute ofFundamental Research, Bangalore, India.

231CDrosophila HOPS and AP-3 complex genes are required for anendocytic-dependent Notch signaling pathway. P. Tongngok1,M. Wilkin1, N. Gensch1, S. Clemence1, M. Motoki1, K. Yamada2,K. Hori2, M. Taniguchi-Kanai2, E. Franklin1, K. Matsuno2, M.Baron1. 1) Faculty of Life Sciences, University of Manchester,Manchester, United Kingdom; 2) Tokyo University of Science,Department of Biological Science and Technology 2641Yamazaki, Noda, Chiba, 278-8510 Japan.



232AHipk is an essential protein that promotes Notch signaltransduction in the Drosophila eye by inhibition of the global co-repressor Groucho. Esther M. Verheyen1, Wendy Lee1, BryanAndrews1, Michael Faust2, Uwe Walldorf2. 1) Dept. of MolecularBiology and Biochemistry, Simon Fraser University, Burnaby,British Columbia, Canada; 2) Institute for Developmental Biology,University of Saarland, Homburg/Saar, Germany.

233BOdz/Tenm family genes are necessary for wing margin and forNotch target genes' expression. Ron Wides, Nadya Rakovitsky,Yael Kinel-Tahan, Anna Levine. Mina and Everard GoodmanFaculty of Life Science, Bar Ilan University, Ramat-Gan, Israel.

234CFunction and Regulation of Drosophila Epsin. Xuanhua Xie,Janice Fischer. MCDB, University of Texas at Austin, Austin,TX.

235ADownstream signal of Notch receptor diverges into two distinctpathways through its selective endocytic trafficking mediated byDeltex. Kenta Yamada, Kazuya Hori, Kenji Matsuno. Dept. Biol.Sci./Tec., Tokyo Univ. Sci., Noda, Chiba, Japan.

236BRabconnectin-3 alpha and beta regulate endocytic traffickingand Notch signaling in Drosophila. Yan Yan1, Natalie Denef1,Trudi Schüpbach1,2. 1) Department of Molecular Biology,Princeton University, Princeton; 2) HHMI.

237CCasein Kinase I gamma: localization and interaction with PTP-Pez. Veena M. Angadi, Kevin A. Edwards. School of BiologicalSciences, Illinois State University, Normal, IL.

238AAnalysis of the four-jointed enhancer region: localizing elementsfor Wingless and Fat pathways. Natalia I. Arbouzova, HelenMcNeill. Samuel Lunenfeld Research Institute, Toronto, Canada.

239BNinjurin A in immunity and early development. Sarah Broderick,Andrea Page-McCaw. Center for Biotechnology andInterdisciplinary Studies, Dept. of Biology, RPI, Troy, NY.

240CAph-1 is required to regulate Psn-mediated γ-secretase activityand cell survival in Drosophila wing development. Hui-MinChung1, Wu-Min Deng2, Emilie Cooper1,3. 1) Dept Biol, UnivWest Florida, Pensacola, FL; 2) Department of Biological ScienceFlorida State University Tallahassee, FL; 3) EnvironmentalProtection Agency Gulf Ecology Division Gulf Breeze, FL.

241AIntersection of tyrosine kinase signaling and Eyes Absentfunction. Noura M. Dabbouseh1, Anita Saraf2, MichaelWashburn2, Laurence Florens2, Ilaria Rebay1. 1) University ofChicago, Chicago, IL; 2) The Stowers Institute for MedicalResearch, Kansas City, MO.

242BExamination of Invadolysin and its Interactors in Drosophiladevelopment. Francesca Di Cara, Edward Duca, Ching-WenChang, Neville Cobbe, Sharron Vass, Margarete M. S. Heck.Cardiovascular Science, University of Edinburgh, Edinburgh,United Kingdom.

243CSarcoglycans as possible regulators of EGFR signaling inDrosophila eyes. Reina Hashimoto1,2, Masamitsu Yamaguchi2.1) Venture lab, Kyoto Inst of Technology, Kyoto, Japan; 2) AppliedBio Dept, Kyoto Inst of Technology, Kyoto, Japan.

244AThe BMP and Activin Pathways Coordinately Regulate InsulinSignaling in Drosophila. Philip A. Jensen1, Michael B.O'Connor1,2. 1) Department of Genetics, Cell Biology andDevelopment, University of Minnesota, Minneapolis, MN USA;2) HHMI.

245BYorkie has dual roles in Warts pathway signaling to regulate aphotoreceptor subtype fate decision. David Jukam, DanielaPistillo, Claude Desplan. Department of Biology, New YorkUniversity, New York, NY.

246CSerine-361 is the phosphorylation site in Drosophila Arrestin-1.A. Kiselev, J. O'Tousa. Department of Biological Sciences, NotreDame University, Notre Dame, IN 46556.

247ATo be or not to be: how cells survive under hypoxia. Soo-JungLee1, Renny Feldman1,2, Patrick O'Farrell1. 1) Department ofBiochemistry and Biophysics, University of California, SanFrancisco; 2) Gevo Inc., Englewood, CO.

248BA mosaic screen for X-linked mutations affecting photoreceptordifferentiation. Kevin Legent, Magali Richard, JosefaSteinhauer, Jessica Treisman. Skirball Inst, New York Univ MedCenter, New York, NY.

249CRole of Chmp1 Protein in Drosophila. M. Lester1, M. Park2, S.Collier1. 1) Biological Science, Marshall University, Huntington,WV; 2) School of Medicine, Marshall University, Huntington, WV.

250AFermitins in integrin-mediated adhesion. Sushmita Maitra,Danelle Devenport, Nick Brown. Gurdon Institute and Dept ofPDN, University of Cambidge, UK.

251BRetinophilin has a ninaC-dependent role in phototransduction.Kirk Mecklenburg1, Nobuaki Takemori2,3, Naoka Komori3,Hiroyuki Matsumoto3, Roger C. Hardie4, Joseph E. O'Tousa5.1) Dept. of Biol., Indiana University, South Bend; 2) DrosophilaGenetic Resource Center. Saga Ippongi-cho, Ukyo-ku, Kyoto,Japan; 3) Dept. of Biochem. Mol. Biol., Univ. of Oklahoma HSC,Oklahoma City; 4) Department of Physiology, DevelopmentNeuroscience, University of Cambridge, UK; 5) Dept. of BiologicalSciences, Univ. of Notre Dame, Notre Dame, IN.



252CRoles of Eyes Absent in phosphotyrosine signaling networks.Santiago A. Morillo1, Ilaria Rebay1,2. 1) Department of MolecularGenetics and Cell Biology, The University of Chicago, Chicago,IL; 2) Ben May Department for Cancer Research, The Universityof Chicago, Chicago, IL.

253ADevelopment of a High-Throughput Fluorescence Assay toDetermine Eyes absent Substrate Specificity. Alexander Muir1,Richard Jones2, Ilaria Rebay2. 1) The College, University ofChicago, Chicago, IL; 2) Ben May Department for CancerResearch, University of Chicago, Chicago IL.

254BDrosophila VDAC is involved in mitochondrial remodelingprocess. Gihyun Park, Jeehye Park, Jongkyeong Chung.National Creative Research Initiatives Center for Cell GrowthRegulation and Department of Biological Sciences, KAIST, 373-1 Guseong-dong, Yuseong-Gu, Daejeon, 305-701, Korea.

255COverexpression of the dSPARC gene impairs wound healing inthe Drosophila melanogaster model. F. Prada1,2,3, A.Chernomoretz2, C. Alvarez3, A. Llera2, P. Wappner4, E. MartínBlanco3, O. Podhajcer2, Wound Consortium - FP6 EU. 1)Institute of Technology, School of Engineering and Sciences -UADE, Buenos Aires, Argentina (Present address); 2) Laboratoryof Molecular and Cellular Therapy, Leloir Institute, Buenos Aires,Argentina; 3) Instituto de Biología Molecular de Barcelona, ParcCientific de Barcelona, España; 4) Laboratory of Genetics andMolecular Physiology, Leloir Institute, Buenos Aires, Argentina.

256AInhibition of Drosophila Wg signaling by BMP involvescompetition between Mad and Armadillo/β-catenin for dTcfbinding. Maryam Rahnama1, Arial Zeng2, Wendy Lee1, SimonWang1, Esther Verheyen1. 1) Department of Molecular Biologyand Biochemistry, Simon Fraser Univeristy, 8888 UniversityDrive, Burnaby, BC, Canada,; 2) Howard Hughes MedicalInstitute, Beckman Center, Stanford University Medical Center,Stanford, CA, USA.

257BIdentification of Domains Responsible for Ubiquitin-dependentDegradation of dMyc by GSK3β and CKI kinases. SaraRiccardo1, Margherita Galletti2, Federica Parisi1, CarlinaLora1, Leinny Rivas1, Bonnie Wong1, Alexis Serra1, FlorenciSerras3, Daniela Grifoni4, Jin Jiang5, Paola Bellosta1. 1)Biology, City College of the City University of NY, New York, NY;2) Department of Medical Science, University of Modena, Italy;3) Department of Genetics, University of Barcelona, Spain; 4)Alma Mater Studiorum, Dipartimento di Patologia Sperimentale,Bologna, Italy; 5) Department of Developmental Biology, UTSouthwestern Med Center, Dallas, TX, USA.

258Cβ-arrestin Kurtz inhibits ERK function during Drosophiladevelopment. Marla Tipping1, Yoosik Kim2, Mathieu Coppey2,Stanislav Shvartsman2, Alexey Veraksa1. 1) Department ofBiology, University of Massachusetts Boston, Boston, MA; 2)Department of Chemical Engineering and Lewis-Sigler Institutefor Integrative Genomics, Princeton University, Princeton, NJ.

259AInvestigating the role for Signaling pathways during adultmyogenesis in Drosophila. Kumar Vishal, Rachel Adams,Chistropher Carballada, Joyce Fernandes. Department ofZoology, Maimi University, Oxford, OH.

260BInteractions with the Abelson tyrosine kinase revealcompartmentalization of Eyes absent function between nucleusand cytoplasm. Wenjun Xiong, Noura Dabbouseh, IlariaRebay. Ben May Department of Cancer Research, The Universityof Chicago, Chicago, IL.

261CTGFβ signaling regulates steroid hormone synthesis. Ying Ye1,James Warren2, Lawrence Gilbert2, Michael O'Connor1,3. 1)The Department of Genetics, Cell Biology and Development,University of Minnesota, Minneapolis; 2) The Department ofBiology, University of North Carolina, Chapel Hill; 3) HowardHughes Medical Institute, University of Minnesota, Minneapolis.

262ACharacterization of Drosophila Sulfated in cell signaling anddevelopment. Jia You1,2, Xinhua Lin1. 1) Division ofdevelopmental Biology, Cincinnati Children's Hospital MedicalCenter, Cincinnati, OH 45229, USA; 2) The Graduate Programin Molecular and Developmental Biology, Cincinnati Children'sHospital Medical Center, University of Cincinnati College ofMedicine, cincinnati, OH 45229, USA.

263BApical Constriction and Invagination in the Drosophila WingImaginal Epithelium are Induced by Activation of the CanonicalWnt Pathway through Loss of APC2 and APC1. Sandra G.Zimmerman, Lauren M. Thorpe, Vilma R. Medrano, CarolynA. Mallozzi, Brooke M. McCartney. Deptartment of BiologicalSciences, Carnegie Mellon Univ, Pittsburgh, PA.

264CIdentification of New Components Involved RAS/MAPK SignalModulation. Dariel Ashton-Beaucage, Caroline Baril, MalhaSahmi, Marie-Noëlle Sgéuin-Grignon, Chris Udell, Anne-Sophie Guenier, Patrick Gendron, Marc Therrien. Institute forResearch in Immunology and Cancer, Université de Montreal,Montreal, PQ, Canada.

265ARegulating JNK Signaling to Sculpt Tissue Morphology. RebeccaGonda, Beth Stronach. Dept Biol Sci, Univ Pittsburgh,Pittsburgh, PA.

266BCharacterization of epidermal growth factor receptor target genesin Drosophila oogenesis. Lisa A. Kadlec, Jarrod Buzalewski,Michelle Junker, Tanmay Shah, Amit Sharma. Department ofBiology, Wilkes University, Wilkes-Barre, PA.

267CPumilio regulates various developmental processes by negativelyregulating Egfr/Ras/MAPK signaling. Sung Y. Kim, Jiyoung Kim,Changsoo Kim. Sch Biological Sci/Technology, Chonam NatlUniv, Gwangju-Si, Korea.



268APLC-γ modulates differentiation and growth impinging on theMAPK pathway activated by the insulin receptor. Juan ManuelMurillo-Maldonado, Juan Rafael Riesgo-Escovar. Dept. ofDevelopmental Neurobiology, Instituto de Neurobiologia, UNAM,Queretaro, Qro, Mexico.

269BIdentification of Regulators of Hedgehog Secretion by FunctionalGenomics. Reid Aikin, Alexandra Cervantes, Gisela D'Angelo,Laurent Ruel, Sandra Lacas-Gervais, Pascal Thérond.Institute of Developmental Biology and Cancer, CNRSUMR6543, University of Nice Sophia Antipolis, Nice, France.

270CCreating a favorable reproductive tract environment forsuccessful fertilization. Ido Apel, Yael Heifetz. Dept ofEntomology, Hebrew Univ, Rehovot, Israel.

271ACrebA is required for cellular organization and secretory functionin the Drosophila salivary gland. Rebecca M. Fox, DeborahAndrew. Department of Cell Biology, Johns Hopkins School ofMedicine, Baltimore, MD.

272BCharacterization of sec61α during embryogenesis. XiaochenWang, Robert Ward. Dept Molecular Biosciences, Univ Kansas,Lawrence, KS.

273CDTestican Regulates the Extracellular Distribution of Wingless.Yung-Heng Chang1,2, Y. Henry Sun1,2. 1) Graduate Institute ofLife Sciences, National Defense Medical Center, Taipei 114,Taiwan, Republic of China; 2) Institute of Molecular Biology,Academia Sinica, Taipei 115, Taiwan, Republic of China.

274ALipid phosphorylation controls Wnt-mediated inhibition of NF-κB activity. Mark A. McElwain, D. C. Ko, M. D. Gordon, RoelNusse. Developmental Biol, Stanford Univ, Stanford, CA.

275BUncovering a Novel Mode of Cross-Regulation Between the Wgand RTK/EGFR Signaling Pathways. Emily R. Olson, RamanujDasGupta. Pharm, Cancer Inst, NYU Sch Med, New York, NY.

276CHomeodomain-interacting protein kinases (Hipks) promote Wnt/Wg signaling. S. Swarup1, W. Lee1, J. Chen1, T. Ishitani2, E.Verheyen1. 1) Dept. of Molecular Biology and BiochemistrySimon Fraser University,Burnaby, BC, Canada; 2) Division ofCell Regulation Systems, Medical Institute of Bioregulation,Kyushu University,Fukuoka, Japan.

277AUsing site-directed mutants of Drosophila APC2 to investigatethe role of the APC2-Armadillo interaction in Wingless signaltransduction and cytoskeletal function. Meng-Ning Zhou,Fangyuan Zhouzheng, Brooke McCartney. Dept Biological Sci,Carnegie Mellon Univ, Pittsburgh, PA.

Cell Cycle and Checkpoints

278BRegulation of Cortex, an APC activator essential for theDrosophila meiotic cell cycle. Zachary Whitfield, Jillian Pesin,Helena Kashevsky, Terry Orr-Weaver. Whitehead Institute,Dept. of Biology, MIT, Cambridge, MA.

279CEmbryonic String and Twine mRNA degradation and couplingof cell cycle changes to the MZT. Jeffrey A. Farrell, Patrick H.O'Farrell. Tetrad - Cell Biology, University of California, SanFrancisco.

280ARetinoids regulate a developmental checkpoint for Drosophilatissue regeneration. Adrian Halme, Michelle Cheng, AbigailGerhold, Iswar Hariharan. Department of Molecular and CellBiology, University of California at Berkeley, Berkeley, CA.

281BDifferential requirements of a mitotic acetyltransferase in somaticand germ line cells. Ana Rita Marques1, Rui Tostoes1, ThomasMarty2, Vitor Barbosa2, Ruth Lehmann2, Rui Martinho1. 1) InstGulbenkian Ciencia, Oeiras, Portugal; 2) Skirball Institute andHoward Hughes Medical Institute, New York, USA.

282CTranslational regulators control cellular morphogenesis and cellcycle progression during the midblastula transition. OpheliaPapoulas1, Kate Monzo1, Greg T. Cantin2, Cristian Ruse2, JohnR. Yates III2, John C. Sisson1. 1) Sect MCD Biology, Universityof Texas, Austin; 2) Department of Chemical Physiology, TheScripps Research Institute, La Jolla, CA.

283ADrosophila DNA polymerase theta is involved in alternative end-joining repair of DNA double-strand breaks. S. H. Chan1, E. K.Sanchez2, M. McVey1,3. 1) Department of Biology, TuftsUniversity, Medford, MA; 2) Department of Biology, The Universityof Texas at Brownsville, TX; 3) Program in Genetics, Tufts SacklerSchool of Graduate Biomedical Sciences, Boston, MA.

284BCharacterization of Sld5, a Subunit of the GINS Complex.Catherine A. Gouge, Tim W. Christensen. Department ofBiology, East Carolina University, Greenville, NC.

285CEffect of Re-replication on Genome Integrity. MadhuraKadaba, Sonam Mehrotra, Shahina B. Maqbool, Alexis J.Kolpakas, Brian R. Calvi. Department of Biology, IndianaUniversity, Bloomington, IN.

286AThe SUUR protein does not affect the replication fork rate in thesalivary gland polytene chromosomes. T. D. Kolesnikova, S. A.Demakov, A. V. Ivankin, N. G. Andreyenkova, I. F. Zhimulev.Inst Cytology Genetics, Russian Academy of Sciences,Novosibirsk, Russian Federation.

287BRegulation of DNA replication and fork progression. JaredNordman, Giovanni Bosco, Eugenia Park, Terry Orr-Weaver.Whitehead Institute, Cambridge, MA.



288CCyclin J cooperates with armi to control female germline stemcell division. Russell L. Finley1,2, Govindaraja Atikukke2. 1)Ctr Molecular Med Gen, Wayne State Univ Med Sch, Detroit,MI; 2) Dept. of Biochem. and Molecular Biology, Wayne StateUniv Med Sch, Detroit, MI.

289AAn RNAi Screen to Characterize Pathways that Control the CellCycle and Survival. Stephen Guest, Jingkai Yu, Russell FinleyJr. Center for Molecular Medicine and Genetics, Wayne StateUniversity, Detroit, MI.

Cell Death

290BVisualization of caspase activity in vivo. A. Florentin, E. Arama.The Rose Leon Mitchell Laboratory for Cancer Research,Department of Molecular Genetics, Weizmann Institute ofScience, Rehovot, Israel.

291CThe initiator caspase Dronc is not subject to proteasome-mediated degradation. Tom Van Lee, Mayank Srivastava,Andreas Bergmann. Department of Biochemistry MolecularBiology, UT-M D Anderson Cancer Ctr, Houston, TX.

292AThe archipelago growth suppressor limits apoptosis via the Rbf/dE2f1 pathway. Sarah C. Nicholson, M. Melissa Gilbert,Kenneth H. Moberg. Emory University School of Medicine,Department of Cell Biology, Atlanta, GA.

293Bdpp head capsule mutations induce Jun kinase pathwayactivation and apoptosis. Sung-Yeon Park, Brian Stultz,Deborah Hursh. Division of Cell and Gene Therapy,Center forBiologics Evaluation and Research, FDA, Bethesda, MD 20892.

294CRegulation of the Drosophila Apoptosome through FeedbackInhibition. Peter J. Shapiro, Hans Hsu, Heekyung Jung, EdithRobbins, Hyung Don Ryoo. Dept. of Cell Biology, NYU Schoolof Med., New York, NY.

295ACharacterizing the Role of Hsp27 in Embryonic ProgrammedCell Death. Joseph C. Ayoob, Katherine Robertson, JaimeMergliano, Elane Fishilevich, Jonathan S. Minden.Department of Biological Sciences, Carnegie Mellon University,Pittsburgh, PA.

296BThe H3K4me3 histone demethylase Lid is required for cell deathin Drosophila. Andreas Bergmann1, Zhihong Chen1, AmandaBrook1, Herz Hans-Martin2. 1) MD Anderson Cancer Center,Houston, TX; 2) Stowers Insitute, Kansas City, MO.

297CGenetic analysis of steroid-triggered cell death. D. Buhr, K.Konieczko, K. Kopish, A. Bashirullah. University of Wisconsin,Madison, WI.

298ARB-E2F and PI3K-TOR pathway interactions regulate apoptosis.Gabriel M. Gordon1, Jinhua Xu2, Dilip Deb2, Wei Du1,2. 1)Committee on Cancer Biology, University of Chicago, Chicago,IL; 2) Ben May Department for Cancer Research, University ofChicago, Chicago, IL.

299BRegulation of neuroblast apoptosis and proliferation. W. Tang1,2,M. Mabuchi1, Y. Tan1, R. Cannon1, K. White1. 1) Cutaneous Biol.Researcj Center, Massachusetts General Hospital, Charlestown;2) The Forsyth Institute, Harvard School of Dental Medicine,Boston, MA.

300CInvestigating cell death induced by activation of Hippo signaling.Madhuri Kango-Singh1, Krishna Patel1, Kevin Waits1,Shiranee Gunashekhare2, Amit Singh2. 1) Div Basic Sci,Mercer Univ Sch Me, Macon, GA; 2) Department of Biology,University of Dayton, Dayton OH.

301AProgrammed Cell Death in Drosophila melanogaster Germ Cells.Lisa Grantham1, Yukiko Yamada2, Clark Coffman1. 1) GeneticsDevelopment and Cell Biology, Iowa State University, Ames, IA;2) Janelia Farm Research Campus, Howard Hughes MedicalInstitue, Ashburn, VA.

302BRegulation of Mitochondrial Clustering During Programmed CellDeath in the Drosophila Ovary. Elizabeth Ann Tanner, ToddBlute, Kim McCall. Dept of Biology, Boston University, Boston,MA.

303CpH-sensitive GFP reports cell engulfment in Drosophila. E.Fishilevich1, J. A. J. Fitzpatrick1,2, J. S. Minden1. 1) BiologicalSciences, Carnegie Mellon University, Pittsburgh, PA; 2)Molecular Biosensor and Imaging Center, Carnegie MellonUniversity, Pittsburgh, PA.

304ADenervation induced neuronal cell death in the developingDrosophila optic lobes. Hidenobu Tsujimura, Yu Togane, RieAyukawa, Keiichiro Hirai, Kengo Beppu, Yusuke Hara,Tatsuro Enomoto, Hiromi Akagawa. Dept Dev Biol, Tokyo UnivAgric Tech, Tokyo, Japan.

305BMechanism for induction and function of expansion of apoptosisin mutants for Drosophila T-box transcription factor Omb. MakotoUmemori, Takashi Adachi-Yamada. Department of Biology,Graduate School of Science, Kobe University, Japan.

306CA novel mechanism spatially regulating the Dpp survival signal.Offer Gerlitz1, Ziv Oren1, Yaron Suissa1, Hadar Neuman1, TamaDinur1, Peter Geuking2, Christa Rhiner3, Marta Portela3, FidelLolo3, Eduardo Moreno3. 1) Dept Biochemistry, The HebrewUniv, Jerusalem, Israel; 2) Institut fur Molekularbiologie,Universitat Zurich, Switzerland; 3) Spanish National CancerInstitute (CNIO), Madrid, Spain.



307AE2F and p53 induce apoptosis independently during Drosophiladevelopment but intersect in the context of DNA damage. NamSung Moon1,3, Luisa Di Stefano1, Erick J. Morris1, ReenaPatel2, Kristin White2, Nick Dyson1. 1) Massachusetts GeneralHospital Cancer Research Center and Harvard Medical School,Charlestown, Massachusetts, USA; 2) Massachusetts GeneralHospital Cutaneous Biology Research Center, Charlestown,Massachusetts, USA; 3) Current address: Department of Biology,McGill University, Montreal, Quebec, Canada.

308BMultiple regulators of the pro-apoptotic gene hid modulates thesensitivity of rbf mutant cells to apoptosis. Miho Tanaka-Matakatsu, Jinhua Xu, Rahul Kar, Wei Du. Ben MayDepartment for Cancer Research, The University of Chicago,Chicago, IL.

309CEpigenetic control of reaper and hid expression. Lei Zhou1,2,Can Zhang1,2, Yanping Zhang1,2, Nianwei Lin1,2. 1) Dept MolecGenetics/Microbiol, Univ Florida Col Medicine, Gainesville,FL; 2) Shands Cancer Center, Univ Florida Col Medicine,Gainesville, FL.

Cell Division and Growth Control

310ACell competition restrains lethal giant larvae neoplastic growthin Drosophila imaginal epithelia. F. Froldi1, M. Ziosi1, F. Garoia2,A. Pession3, N. Grzeschik4, P. Bellosta5, D. Strand6, H.Richardson4, A. Pession1, D. Grifoni1. 1) ExperimentalPathology, Alma Mater Studiorum, Bologna, BO, Italy; 2)Evolutionary and Experimental Biology, Alma Mater Studiorum,Bologna, BO, Italy; 3) Ginecology, Obstetrics and Pediatrics,Alma Mater Studiorum, Bologna, BO, Italy; 4) Research Division,Peter MacCallum Cancer Centre, East Melbourne Victoria,Australia; 5) City College of the City University of NY, Departmentof Biology, New York, USA; 6) Johannes Gutenberg University,First Department of Internal Medicine, Mainz, Germany.

311BOutput switching of JNK signaling in cell competition andepithelial maintenance. Shizue Ohsawa, Tatsushi Igaki. Deptof Cell Biol, Kobe Univ, Kobe, Japan.

312CExpression of dMyc in vivo in the Fat Body regulates organismalgrowth. Carlina Lora1, Mahesh Saqcena1, Federica Parisi1,2,Sara Riccardo1, Daniela Grifoni2, Paola Bellosta1. 1) Biology,City College of New York, New York City , NY; 2) Alma MaterStudiorum, Dipartimento di Patologia Sperimentale, Bologna,Italy.

313AdMyc controls growth and apoptosis in vivo downstream of thesmall GTPase Rheb. Federica Parisi1,2, Sara Riccardo1, GiadaTomba2, Mahesh K. Saqcena1, Margaret Daniel1, DanielaGrifoni2, Paola Bellosta1. 1) City College of the City Universityof NY, Department of Biology, NY, USA; 2) Dept ExperimentalBiol, Alma Mater Studiorum, Bologna, Italy.

314BAnillin stabilizes membrane-cytoskeleton interactions duringDrosophila male germ cell cytokinesis. Philip D. Goldbach1,2,Raymond Wong1,3, Julie Brill1,2,3. 1) Dept Stem Cell andDevelopmental Biol, Hosp Sick Children, Toronto, ON, Canada;2) Dept Molecular Genetics, University of Toronto; 3) Institute ofMedical Science, University of Toronto.

315CFunctional characterization of Cindr in Drosophila melanogaster.Kaisa Haglund1, Dafne Lemus1, Caroline Grabbe2,3, RuthPalmer2, Ivan Dikic3, Ioannis Nezis1, Harald Stenmark1. 1)Department of Biochemistry, Institute for Cancer Research,Centre for Cancer Biomedicine, The Norwegian Radium Hospital,N-0310 Oslo, Norway; 2) Umeå Centre for MolecularPathogenesis, Umeå University, S-90187 Umeå, Sweden; 3)Institute of Biochemistry II, Frankfurt University Medical School,Theodor-Stein-Kai 7, D-60590 Frankfurt, Germany.

316AFunctional characterization of Drosophila Alix. Dafne Lemus,Kaisa Haglund, Harald Stenmark. Department of Biochemistry,Institute for Cancer Research, The Norwegian Radium Hospital,Montebello, 0310 Oslo, Norway.

317BThe chaperonin containing TCP-1 (CCT) complex is a target ofFragile X mental retardation protein-dependent regulation inDrosophila cleavage stage embryos. Kate Monzo1, Susan R.Down2, Jonathan S. Minden2, John C. Sisson1. 1) The Sectionof Molecular Cell and Developmental Biology and The Institutefor Cellular and Molecular Biology, The University of Texas atAustin, Austin, TX; 2) The Department of Biological Sciences,Carnegie Mellon University, Pittsburgh, PA.

318CMyosin Phosphatase and Incomplete Cytokinesis duringGermline Cyst Formation. S. Ong, C. Foote, C. Tan. DeptBiological Sci, Univ Missouri, Columbia, Columbia, MO.

319AFunctional characterization of Poly: a novel essential proteininvolved in the Insulin Receptor signalling pathway. E. Bolukbasi,S. Vass, N. Cobbe, M. M. S. Heck. Cardiovascular Sciences,University of Edinburgh, Edinburgh, United Kingdom.

320BPhosphorylation by Aurora B and POLO controls MEI-S332localization to the centromere. Helena E. Kashevsky1, CristinaNogueira1, Astrid Clarke1, Terry Orr-Weaver1,2. 1) WhiteheadInst, Cambridge, MA; 2) Dept. of Biology, MIT, Cambridge, MA.

321CPAP and GLD-2 poly(A) polymerases act sequentially incytoplasmic polyadenylation during Drosophila oogenesis.Catherine Papin1, Perrine Benoit1, Jae Eun Kwak2, MarvinWickens2, Martine Simonelig1. 1) Institut de GénétiqueHumaine, CNRS, Montpellier, France; 2) Department ofBiochemistry, University of Wisconsin, Madison.



322AThe regulation of calcineurin by Sra/RCAN plays a critical rolein completion of meiosis in the Drosophila female. S. Takeo1, S.Hawley1, T. Aigaki2. 1) Stowers Institute for Medical Research,Kansas City, MO; 2) Department of Biological Sciences, TokyoMetropolitan University, Hachioji, Tokyo.

323BApplication of fluorescence in situ hybridization (FISH) in studiesof heterochromatin pairing in Drosophila male meiosis. J. Tsai,B. McKee. University of Tennessee, Knoxville, TN.

324CSearching for novel genetic interactors of α-endosulfine and theirrole in meiotic maturation. Jessica Rivera Von Stetina, Min-Young Kim, Kimi LaFever, Daniela Drummond-Barbosa. DeptCell Dev Biol, Vanderbilt Univ, Nashville, TN.

325ARegulation of Regenerative Growth in the Eye Imaginal Disc.Abigail R. Gerhold, Iswar K. Hariharan. Molec Cell Biol, UnivCalifornia, Berkeley, Berkeley, CA.

326BRegenerative growth in imaginal discs. Melanie I. Worley, RachelK. Smith-Bolton, Iswar K. Hariharan. Molec Cell Biol, UnivCalifornia, Berkeley, Berkeley, CA.

327CIntegration of Insulin Receptor/FOXO signaling and dMyc activityduring muscle growth regulates body size. Fabio Demontis1,Norbert Perrimon1,2. 1) Department of Genetics, HarvardMedical School, Boston, MA; 2) Howard Hughes MedicalInstitute, Harvard Medical School, Boston, MA.

328AProper regulation of cytoskeletal genes is essential to restraingrowth of epithelia. Beatriz García Fernández, Sofia Rebelo,Maurícia Vinhas, Pedro Gaspar, Barbara Jezowska, CatarinaBrás-Pereira, Florence Janody. Instituto Gulbenkian deCiência, Oeiras, Portugal.

329BSUMOylation is essential for cell cycle progression in developingimaginal discs. Kiriaki Kanakousaki, Matthew C. Gibson.Stowers Institute for Medical Research, Kansas City, MO.

330CCharacterization of Cyclin Y, a novel cyclin essential formetamorphosis in Drosophila. Dongmei Liu, Finley Russell.Dept CMMG, Wayne State Univ, Detroit, MI.

331AMapping and phenotypic analysis of fried, a gene required foregg chamber maturation, larval growth, and puparialdevelopment. Thomas McCord, Kimberly Silletti, RebeccaPersky, Jason Morris. Department of Natural Sciences,Fordham University, New York, NY.

332BThe Hippo pathway requires de2f1 to promote inappropriate cellproliferation. Brandon N. Nicolay, Maxim V. Frolov. Departmentof Biochemistry and Molecular Genetics,University of Illinois-Chicago.

333CAn in vivo RNAi screen for tissue growth regulators in Drosophila.Clara M. Sidor1, Ruth Brain1, Eliana P. Lucas1, Georg Dietzl2,Barry J. Dickson2, Barry J. Thompson1. 1) Epithelial BiologyLaboratory, Cancer Research UK, London, United Kingdom; 2)Research Institute of Molecular Pathology (IMP) Dr. Bohr-Gasse7, A-1030 Vienna, Austria.

334AAnalysis of the biochemical and cellular defects of gatA loss-of-function mutants in Drosophila larvae. Kimberly Silletti, ThomasMcCord, Anna Kruyer, Leah Bergman, Olivia Moffitt,Christopher O'Connor, Jane Mueller, Joseph Carnevale,Rebecca Persky, Jason Morris. Department of NaturalSciences, Fordham University, New York, NY.

335BDrosophila Pico and its mammalian ortholog Lamellipodinactivate Serum Response Factor and promote cell proliferation.Eleanor Taylor1,2, Ekaterina Lyulcheva2, Magdalene Michael3,Anne Vehlow3, Shengjiang Tan2, Adam Fletcher2, MatthiasKrause3, Daimark Bennett1,2. 1) School of Biological Sciences,University of Liverpool, UK; 2) Department of Zoology, Universityof Oxford, UK; 3) Randall Division of Cell Molecular Biophysics,Kings College London, UK.

336CThe role of dMyc in pattern-directed growth during developmentof the Drosophila wing. D. Christine Wu1, Laura A. Johnston2.1) Biological Sciences, Columbia University, NY; 2) GeneticsDevelopment, Columbia University, NY.

337ARegulation of Invasive Cell Growth by Axon Guidance Genes.M. Duman-Scheel1,2, E. Flannery2, A. VanZomeren-Dohm1, A.Maltere2, P. Beach3, W. Simanton3. 1) Medical and MolecularGenetics, IUSM-South Bend at Notre Dame, South Bend, IN; 2)Dept. of Biological Sciences, University of Notre Dame, NotreDame, IN; 3) Biology Dept., Albion College, Albion, MI.

338BLoss of RecQ5 leads to spontaneous mitotic defects andchromosomal aberrations in Drosophila melanogaster. K.Kawasaki, H. Sakurai, M. Nakayama, S. Yamaguchi, Y. Sagisu,F. Ito. Setsunan University, Osaka, Japan.

339CIdentifying novel substrates of the hippo tumor suppressorpathway. Cathie M. Pfleger1, Andreas Jenny2, MaryamJahanshahi1, Kuangfu Hsiao1, Elizabeth Horvath1, Hua Yan1.1) Dept Oncological Sci, Mount Sinai Sch Med, New York, NY;2) Department of Developmental and Molecular Biology, AlbertEinstein College of Medicine, NY.

340AInvestigation of post-translational mechanisms regulating the Fattumor-suppressor pathway. Richelle Sopko1, Laura Gardano2,Helen McNeill1. 1) Samuel Lunenfeld Research Institute, Toronto,ON, Canada; 2) Centre for System Biology at Edinburgh,University of Edinburgh, The Kings Buildings, Edinburgh,Scotland, UK.



341BdMyc function downstream Yorkie reveals new rules for cellcompetition and adds complexity to the Hippo pathway. M. Ziosi1,L. A. Baena-López2, F. Froldi1, F. Garoia3, P. Bellosta4, D.Grifoni1, A. Pession1. 1) Experimental Pathology, Alma MaterStudiorum, Bologna, Italy; 2) National Institute for MedicalResearch, London, UK; 3) Evolutionary and ExperimentalBiology, Alma Mater Studiorum, Bologna, Italy; 4) City Collegeof the City University of NY, Department of Biology, New York,USA.

Chromatin and Epigenetics

342CTousled-like kinase regulates ASF1 chaperon stability. MaximPilyugin1, François Karch1, Peter Verrijzer2, JeroenDemmers2, Yuri Moshkin2. 1) Dept Zoology Animal Biol, UnivGeneva, Geneva, Switzerland; 2) Erasmus University MedicalCenter, Rotterdam, Netherlands.

343ACharacterization of the Drosophila Scaffold Attachment FactorB (SAFB). Catalina Alfonso, Keith Maggert. Dept Biochem/Biophysics, Texas AUniv, College Station, TX.

344BFACS purification of crosslinked, antibody-labeled Drosophilaembryonic nuclei for analysis of chromatin structure. Sarah K.Bowman1,2, David M. Dombkowski3, Frederic I. Preffer3,Robert E. Kingston1,2. 1) Department of Molecular Biology,Massachusetts General Hospital, Boston, MA; 2) Departmentof Genetics, Harvard Medical School, Boston MA; 3) Departmentof Pathology, Massachusetts General Hospital and HarvardMedical School, Boston MA.

345CThe JIL-1 histone H3S10 kinase regulates chromatin structureby multiple and partially redundant mechanisms in Drosophila.W. Cai, X. Bao, H. Deng, W. Zhang, J. Girton, J. Johansen, K.M. Johansen. Department of Biochemistry, Biophysics, andMolecular Biology, Iowa State University, Ames, IA.

346ARecognition of Double Strand Breaks by a mutator protein (MU2)in Drosophila melanogaster. Raghuvar G. Dronamraju, JamesM. Mason. NIEHS, Res Triangle Park, NC.

347BSequence-dependent initiation and sequence-independentspreading of MSL complex to active genes on the male Xchromosome. Andrey A. Gorchakov1,2, Artyom A.Alekseyenko1,2, Shouyong Peng1,3, Erica Larschan1,2, Ok-Kyung Lee1, Peter Kharchenko3, Sean D. McGrath4, CharlotteI. Wang2, Elaine R. Mardis4, Peter J. Park1,3, Mitzi I. Kuroda1,2.1) Division of Genetics, Dept. of Medicine, HPCGG, BWH,Boston, MA; 2) Department of Genetics, HMS, Boston, MA; 3)Childrens Hospital Informatics Program, Childrens Hospital,Boston, MA; 4) Department of Genetics and GenomeSequencing Center, Washington University School of Medicine,St. Louis, MO.

348CChanges in Chromatin Structure Correlate with TranscriptionalActivity of Nucleolar rDNA in Polytene Chromosomes. M.Labrador, M. P. Plata, H.-J. Kang, S. Zhang, S. Kuruganti, S.-J. Hsu. Biochemistry Cell and Molecular Biology, The Universityof Tennessee, Knoxville, TN.

349AThe role of RNAi and histone variants in the regulation ofDp(1:f)LJ9 imprinted garnet expression. William AndrewMacDonald1, Vett Lloyd2. 1) Dept Biol, Dalhousie Univ, 1355Oxford St., Halifax, NS, B3H 4J1, Canada; 2) Dept. Biology, Mt.Allison University, 63B York St. Sackville, NB, E4L 1G7, Canada.

350BHP1 is distributed along the length of the retrotransposon arrayin Drosophila telomeres. James M. Mason1, Radmila CapkovaFrydrychova1, Trevor K. Archer2. 1) Lab Molec Genetics, NIH/NIEHS, Res Triangle Park, NC; 2) Lab Molec Carcinogen, NIH/NIEHS, Res Triangle Park, NC.

351CCharacterization of GAGA-Binding Protein Complexescontaining the Drosophila Pipsqueak Protein. S. Schmitt1, Y. Liu1,A. Gradolatto2, A. J. Tackett2, M. Lehmann1. 1) Department ofBiological Sciences, University of Arkansas, Fayetteville; 2)Department of Biochemistry and Molecular Biology, Universityof Arkansas for Medical Sciences, Little Rock.

352AMolecular genetic analysis of Su(z)2 identifies functionaldomains. C.-t. Wu, S. Nguyen, H. Genetti, J. Lokere, R. B.Emmons. Dept Gen, Harvard Med Sch, Boston, MA.

353BInvestigating the hybrid incompatibility protein LHR throughinteractions with heterochromatin proteins. Nicholas J. Brideau,Daniel A. Barbash. Dept. of Molecular Biology and Genetics,Cornell University, Ithaca, NY.

354CComparative Analysis of the Drosophila mojavensis DotChromosome. Matthew D. Dothager, Taylor Cordonnier,Wilson Leung, Chris Shaffer, Sarah Elgin, GEP Students andFaculty. Washington University, St. Louis, MO.

355AThe Genomics Education Partnership. S. C. R. Elgin1, V.Chandrasekaran2, H. M. Chung3, C. Coyle-Thompson4, D.Johnson5, C. J. Jones6, N. Kokan7, G. McNeil8, A. Nagengast9,K. Saville10, J. Stamm11, M. Wawersik12, D. Lopatto13. 1)Washington Univ., St. Louis, MO; 2) St. Mary's College, CA; 3)Univ. of West Florida; 4) California State Univ., Northridge; 5)George Washington Univ., Washington, DC; 6) Moravian College,PA; 7) Cardinal Stritch Univ., WI; 8) York College, CUNY, NY; 9)Widener Univ., PA; 10) Albion College, MI; 11) Univ. of Evansville,IL; 12) College of William Mary, VA; 13) Grinnell College, IA.



356BFunctional annotation of essential genes in the centricheterochromatin of chromosome 3. G. Hallson1, M. Syrzycka1,R. Hollebakken2, D. A. R. Sinclair1, K. A. Fitzpatrick3, K.Simonetto1, I. Kim1, A. Berscht1, S. Rayworth1, B. M. Honda1.1) Dept of MBB, Simon Fraser Univ., Burnaby, BC, Canada; 2)Faculty of Health Sciences, Simon Fraser Univ., Burnaby, BC,Canada; 3) Dept of Biological Sciences, Simon Fraser Univ.,Burnaby, BC, Canada.

357CAn investigation into the targeting of heterochromatin formationin trans using double-stranded hairpin RNAs in Drosophilamelanogaster. Kathryn L. Huisinga, Sarah C. R. Elgin. Dept ofBiology, Washington University, Saint Louis, MO.

358AStudies of the Enhanced Male Lethality of Mutants for HOAP. H.Li, R. Kellum. Dept Biol, Univ Kentucky, Lexington, KY.

359BP element dependent gene silencing of w+ transgenes inDrosophila. John Locke, Alireza Sameny, Andersen Lu, ScottHanna. Dept Biological Sci, Univ Alberta, Edmonton, AB,Canada.

360CDo defects in heterochromatin structure cause hybrid lethality?Shamoni Maheshwari, Daniel A. Barbash. Dept. of MolecularBiology and Genetics, Cornell University, Ithaca, NY.

361ACharacterization of modifiers of a variegating w+ transgene onchromosome 4. Allen McCracken, Scott Hanna, AmandaPisio, John Locke. Biological Sciences, University of Alberta,Edmonton, Alberta, Canada.

362BTo what degree do P element reporters reflect the expressionstate of the genes near their insertion site? Elizabeth Messer,Nicole C. Riddle, Sarah C. R. Elgin. Department of Biology,Washington University in St. Louis, St. Louis, MO.

363CThe rDNA exhibits different roles in the nucleus. SilvanaParedes, Keith Maggert. Dept Biol, Texas AUniv, CollegeStation, TX.

364AThe epigenetic telomeric trans-silencing behaves as a generalrepression mechanism. Stéphane Ronsseray1, Laure Teysset1,Augustin de Vanssay1, Anne-Laure Todeschini1,2, ThibautJosse1, Valérie Delmarre1. 1) Biol. du développement,UMR7622/ CNRS - Univ. Pierre Marie Curie, Paris, France; 2)Institut Jacques Monod, UMR7592/ CNRS - Univ. Denis Diderot,Paris, France.

365BExamining the DNA damage response in heterochromatin: therole of dPIAS, a SUMO E3 ligase. Joel Swenson1, Irene Chiolo2,Gary Karpen1,2. 1) Molecular and Cell Biology, University ofCalifornia-Berkeley, Berkeley, CA; 2) Department of Genomeand Computational Biology, Lawrence Berkeley NationalLaboratory, Berkeley, CA.

366CThe identification of factors involved in heterochromatinspreading and gene silencing. Luka N. Zirbel, Kaitlin M.Flannery, Diane E. Cryderman, Lori L. Wallrath. Departmentof Biochemistry, University of Iowa, Iowa City, IA 52242.

367ALoss of the Sin3A/Rpd3 histone de-acetylase complex causespolytene chromosome telomeric fusions. D. F. V. Corona1, G.Burgio1, F. Cipressa2, G. Cenci2. 1) Dipartimento di ScienzeBiochimiche DTI c/o Universita' di Palermo, Palermo, Italy; 2)Dipartimento di Biologia di Base ed Applicata, UniversitàdellAquila, Italy.

368BProtein Phosphatase Type 1 is required for dephosphorylationof histone H3Ser10 during interphase in Drosophilamelanogaster. Peter Glenday1,2, Andrey Rudenko2, EleanorTaylor1,2, Ekaterina Lyulcheva1,2, Emese Vissi2, Luke Alphey2,Daimark Bennett1,2. 1) School of Biological Sciences, Universityof Liverpool, UK; 2) Department of Zoology, University of Oxford,UK.

369CAtrophin recruits G9a and Rpd3 to modify histone H3-K9 and todetermine cell fates. Hongxing Gui, Lei Wang, Chih-chengTsai. Physiology and Biophysics, UMDNJ, Piscataway, NJ.

370ALocal gene organization influences chromatin composition attranscription start sites. Sasha Langley1,2, Gary Karpen1,2. 1)University of California at Berkeley, Berkeley, CA; 2) LawrenceBerkeley National Laboratory, Berkeley, CA.

371BHeterochromatin Protein 1a stimulates histone H3 lysine 36demethylation by the Drosophila KDM4A demethylase. Chia-Hui Lin1, Bing Li2, Selene Swanson1, Ying Zhang1, LaurenceFlorens1, Michael P. Washburn1, Susan M. Abmayr1, Jerry L.Workman1. 1) Stowers Institute for Medical Research, KansasCity, MO; 2) Department of Molecular Biology, University of TexasSouthwestern Medical Center, Dallas, TX.

372CChromatin modifying enzymes in chorion gene amplification.Kristopher H. McConnell, Brian Calvi. Biology, IndianaUniversity, Bloomington, IN.

373AGenome-Wide Mapping of Chromosomal Proteins in Drosophila.A. Minoda1, A. Alekseyenko2, S. Gadel3, S. Marchetti3, N.Riddle3, Y. Schwartz4, A. Gorchakov2, C. Kennedy1, G.Shanower4, S. Elgin3, P. Kharchenko2, M. Kuroda2, P. Park2, V.Pirrotta4, G. Karpen1. 1) Dept Genome Comp Biol, LBNLBerkeley, CA; 2) Dept. of Genetics, Harvard-Partners Center forGenetics Genomics, Boston, MA; 3) Dept Biology, WashingtonUniversity, St Louis, MO; 4) Dept of MBB, Rutgers University,Piscataway, NJ.

374BLoss of the histone variant H2A.Z restores capping to checkpointdefective telomeres in Drosophila. Yikang S. Rong. Laboratoryof Biochemistry and Molecular Biology, NCI, NIH, Bethesda, MD.



375CAn enhancer-blocking insulator at boundary of even skipped andTER94 causes transgene homing, and contributes to long-rangeenhancer-promoter interactions. Miki Fujioka, Xian Wu, JamesB. Jaynes. Dept Biochem Mol Biol, Thomas Jefferson Univ,Philadelphia, PA.

376AExamining Chromatin Structure and Dynamics at Boundary-Element Associated Factor (BEAF) Binding Sites. Matthew K.Gilbert, Craig M. Hart. Dept Biological Sci, Louisiana State Univ,Baton Rouge, LA.

377BPotential role of tRNA genes as heterochromatin barriers inDrosophila melanogaster. Paola A. Guerrero, Keith Maggert.Dept Biol, Texas A M Univ, College Station, TX.

378CGenome-wide Map of BEAF Binding Sites. Nan Jiang, Craig M.Hart. Dept Biological Sci, Louisiana State Univ, Baton Rouge, LA.

379ATransvection mediated by gypsy insulators in Drosophilamelanogaster. Srilalitha Kuruganti, Mariano Labrador.Biochemistry, Cellular and Molecular Biology The University ofTennessee, Knoxville, TN.

380BThe effects of Drosophila gypsy insulator interactions in thecontrol of transcriptional activation by distal enhancers. M.Labrador, H.-J. Kang. Biochemistry Cell and Molecular Biology,The University of Tennessee, Knoxville, TN.

381CEpigenetic Regulation of the Irradiation Responsive EnhancerRegion in Drosophila Embryos. Nianwei Lin, Yanping Zhang,Can Zhang, Ming Tang, Lei Zhou. Department of MolecularGenetics Microbiology, University of Florida, Gainesville, FL.

382AUse of LacI:lacO tethering system to define mechanisms ofinsulator action. David J. Marion1,2, Kate Appleton2, Brian J.McCluskey2, Pamela K. Geyer1,2. 1) Genetics Program; 2) DeptBiochemistry, Univ Iowa, Iowa City, IA. 52242.

383BIdentification of the Drosophila genomic regulatory units by mappingof insulator elements. Nicolas Negre, Parantu Shah, CarolynMorrison, Kevin White. IGSB, University of Chicago, IL.

384CGenome Organization Mediated by Gypsy EndogenousInsulators. H. Wallace, H.-J. Kang, M. P. Plata, M. Ross, M.Labrador. Biochemistry and Cellular and Molecular Biology, TheUniversity of Tennessee, Knoxville, TN.

385AGenome wide ChIP-chip analyses of dCTCF reveal importantroles for insulator proteins in Drosophila genome organization.Jumin Zhou1, Sheryl Smith1,5, Priyankara Wickramasinghe1,Andrew Olson2, Dmitri Loukinov3, Lan Lin1, Joy Deng1,Yangpin Xiong1, John Rux1, Ravi Sachidanandam4, VictorLobanenkov3, Hao Sun1. 1) Gene Expression and RegulationProgram, Wistar Inst, Philadelphia, PA 19104; 2) DartNeuroscience LLC, 7473 Lusk Blvd. Suite 200, San Diego, CA92121; 3) National Institute of Allergy and Infectious Diseases,Rockville, MD 20852; 4) Department of Genetics and GenomicSciences, Mount Sinai School of Medicine, 1425 MadisonAvenue, NY 10029; 5) Department of Biology, Arcadia University,450 S. Easton Road, Glenside, PA 19038.

386BAssessing the generality of enhancer action in trans. Jack R.Bateman. Biology Department, Bowdoin College, Brunswick, ME.

387CStudies on the function of the Male Specific Lethal (MSL)complex. James A. Birchler, Lin Sun, Harvey Fernandez,Michael Hinten. Dept Biological Sci, University of Missouri,Columbia.

388ACharacterization of the GINS complex subunit psf2. Laura M.Henderson, Tim W. Christensen. Biology, East CarolinaUniversity, Greenville, NC.

389BA Male-Specific Effect of Dominant-Negative Fos. Wooly Pierre,Rosa Morra, John Lucchesi, Barry Yedvobnick. Biology,Emory University, Atlanta, GA.

390CA novel genetic screen to identify regulators of MSL complexassembly and activity. Mahalakshmi Prabhakaran1, Pei-HouZhang2, Yoon-Kyung Shim2, Richard Kelley1,2. 1) DeptDevelopmental Biol, Baylor Col Medicine, Houston, TX; 2) DeptMolecular and Cellular Biology, Baylor College of Medicine,Houston, TX.

391ACharacterization of the GINS subunit Psf1 in DrosophilaMelanogaster. Brian D. Sufrinko, Tim W. Christensen. EastCarolina University, Greenville, NC.

392BInhibition of RNA interference by cell death signaling. WeiwuXie, James A. Birchler. Biological Science Division, Universityof Missouri, Columbia.

393CFunctional analysis of Polycomb and Trithorax group chromatinfactors in eye development. Jawaid A. Baig1, FrancoiseChanut2, Tom B. Kornberg3, Ansgar Klebes1,3. 1) FreieUniversität Berlin, Genetics Arnimallee 7 14195 Berlin; 2) GeorgeWilliams Hooper Foundation, UC San Francisco, CA 94143-0552; present address: Office of Career and ProfessionalDevelopment, UC San Francisco, CA 94143-0376; 3) Universityof California, San Francisco, Dept. of Biophysics andBiochemistry, CA 9143, USA.



394AThe PcG protein Pleiohomeotic maintains both active andrepressed transcriptional states through a single binding site inan even skipped maintenance element. Miki Fujioka, JamesB. Jaynes. Dept. of Biochemistry Molecular Biology, ThomasJefferson Univ., Philadelphia, PA.

395BIdentification of proteins that physically interact with TnaA, atrithorax group protein with a putative SUMO E3 ligase function.Lucia Gutierrez-Aguiar1, R. A. Juarez-Uribe1, Mario Zurita1,James A. Kennison2, Martha Vazquez1. 1) Dpto. de FisiologíaMolecular y Genética del Desarrollo, Inst. de Biotecnología,Universidad Nacional Autónoma de México, Cuernavaca, Mor.62250, MEXICO; 2) Laboratory of Molecular Genetics, EuniceKennedy Shriver National Institute of Child Health and HumanDevelopment, National Institutes of Health, Bethesda, Maryland20892.

396CDSP1, a component of a novel protein complex in Drosophilaembryos. Daniel Locker, Martine Decoville, Olivier Lamiable.CBM CNRS, rue C. Sadron 45071 Orleans, France.

397AEpigenetic chromatin states of Polycomb target genes. Yuri B.Schwartz1, Tatyana G. Kahn1, Per Stenberg2, Katsuhito Ohno1,Richard Bourgon3, Vincenzo Pirrotta1. 1) Dept Mol BiolBiochem, Rutgers Univ, Piscataway, NJ; 2) Umeå Center forMolecular Pathogens, Umeå University, Umeå, Sweden; 3)EMBL-EBI, Cambrigde, UK.

398BAcetylation of histone H3K27 by Drosophila CBP blocks itstrimethylation by E(Z) and antagonizes Polycomb silencing. FengTie1, Rakhee Banerjee1, Andrei Zlobin2, Carl Stratton1,Jayashree Prasad-Sinha1, Peter Scacheri1, Manuel Diaz2,Peter Harte1. 1) Dept Genetics, Case Western Reserve Univ,Cleveland, OH; 2) Department of Medicine and OncologyInstitute, Loyola University, Maywood, IL.

399CFunctional Interaction between the Nucleosome RemodelingFactor ISWI and the Hsrω non-coding RNA. D. F. V. Corona1, M.C. Onorati1, S. Lazzaro1, W. Arancio1, S. Iyer2, M. Mallik3, S. C.Lakhotia3. 1) Dipartimento di Scienze Biochimiche and DulbeccoTelethon Institute, Universita' di Palermo, Palermo, Italy; 2)Department of Molecular Human Genetics, Banaras HinduUniversity. Varanasi, India; 3) Cytogenetics Laboratory,Department of Zoology, Banaras Hindu University, Varanasi,India.

400AHistone Lysine Demethylases Cooperate with the BrahmaComplex in Gene Repression. Brenda Curtis1, Dan Marenda2,Claudia Zraly1, Andrew Dingwall1. 1) Oncology Institute,SSOM, Loyola Univ Chicago, Maywood, IL; 2) Drexel Univ, PA.

401BBrahma complex dependent gene repression is mediatedthrough effects on RNA Polymerase elongation. AndrewDingwall, Claudia Zraly. Oncology Inst, SSOM, Loyola UnivChicago, Maywood, IL.

402CRBF1 and the Condensin II subunit dCAP-D3 cooperate toregulate transcription. Michelle S. Longworth1,2, Margarete M.S. Heck3, Nicholas J. Dyson1,2. 1) Molecular Oncology,Massachusetts General Hospital Cancer Center, Charlestown,MA; 2) Harvard Medical School, Boston, MA; 3) University ofEdinburgh, Queen's Medical Research Institute, Centre forCardiovascular Science, Edinburgh EH16 4TJ.

Drosophila Models of Human Diseases

403ALoss of Differentiation drives cancer progression: ato/Atoh1 is atumor suppressor. Wouter Bossuyt1,2, Avedis Kazanjian3, SteinAerts2, Natalie de Geest2, Sofie Van Kelst2, Gert De Hertogh3,Karel Geboes4, Greg P. Boivin3, Marinee Chuah5, ThierryVandenDriessche5, Peter Marynen6, Jan Cools6, Noah F.Schroyer3, Bassem A. Hassan2. 1) Biochemistry and MolecularBiology, M. D. Anderson Cancer Center, Houston, TX; 2)Department of Molecular and Developmental Genetics, VIB, K.U. Leuven School of Medicine, Belgium; 3) Division ofGastroenterology, Hepatology and Nutrition; and Division ofDevelopmental Biology, Children's Hospital ResearchFoundation, Cincinnati, Ohio; 4) Department of Pathology,Leuven University Hospital, K. U. Leuven, Belgium; 5) TheVesalius Research Center, VIB, K. U. Leuven School of Medicine,Belgium; 6) Department of Molecular and DevelopmentalGenetics, VIB, K. U. Leuven School of Medicine, Belgium.

404BHeritability of Variable Toxicity Post Chemotherapy Treatment.Galina Dvorkina, Anthony Long. Ecology Evolutionary Biol,Univ California, Irvine, CA.

405CWnt-dependent changes in cell fate and morphogenesis in thewing imaginal disc result from loss of the Drosophila homologuesof the APC tumor suppressor. R. Martz, K. Kravarik, L. Thorpe,S. Zimmerman, B. McCartney. Department of BiologicalSciences, Carnegie Mellon University, Pittsburgh, PA.

406AThe Sno oncogene antagonizes Wingless signaling. Stuart J.Newfeld, Janine C. Quijano, Michael J. Stinchfield. School ofLife Sciences, Arizona State Univ, Tempe, AZ.

407BIncreased TGFβ signaling drives phenotype progression in aDrosophila model of muscular dystrophy. Jeffery A. Goldstein1,Sean M. Kelly1, Matthew J. Wolf2, Howard A. Rockman3,Elizabeth M. McNally1. 1) Biological Sciences Division,University of Chicago, IL; 2) Department of Medicine, DukeUniversity, Durham, NC; 3) Department ofCell Biology, DukeUniversity, Durham, NC.

408CGenetic and Pharmacological Effectors of Heart Failure in aDrosophila Model of Friedreich's Ataxia. Luan Wang, DouglasRuden. Institute for Environmental Health Sciences, Wayne StateUniversity, Detroit, MI.



409APhenotypic analysis of lysosomal storage disease genes duringDrosophila embryonic neural development. Quynh Chu-LaGraff,Cassandra Blanchette. Department of Biology, Union College,Schenectady, New York 12308.

410BDrosophila tubulin chaperone E functions at neuromuscularsynapses and is required for microtubule network formation. S.Jin, L. Y. Pan, Z. H. Liu, Q. F. Wang, Y. Q. Zhang. Inst Gen DevBiol, Beijing, China.

411CRequirement for O-mannosylation in Drosophila development.Dmitry Lyalin, Naosuke Nakamura, Stacey Whitman, KateKoles, Vlad Panin. Dept Biochemistry Biophysics, TexasAUniversity, College Station, TX.

412ACharacterization of a novel Drosophila model of FRAXEhereditary mental retardation identifies pro-neural bHLH proteinsas conserved transcriptional targets. Daniel R. Marenda1,Andrew Gangemi2, Aleister J. Saunders1,3, PreetiKhandelwal1, Ginnene DiStefano1. 1) Deptartment of Biology,Drexel University, Philadelphia, PA; 2) Department of BiologicalSciences, University of the Sciences in Philadelphia,Philadelphia, PA; 3) Department of Biochemistry and MolecularBiology, Drexel University College of Medicine, Philadelphia, PA.

413BThe cell adhesion molecules SNS and Duf/Kirre are requiredfor the formation and function of a slit diaphragm-like structurein the Garland Cell Nephrocytes. Huanjie Shao, Shufei Zhuang,Fengli Guo, Susan M. Abmayr. Stowers Institute for MedicalResearch, Kansas City, MO.

414CDrosophila melanogaster mutants for the peroxisome assemblygene PEX1 resemble patients of the peroxisome biogenesisdisorder, Zellweger syndrome. Maninder Virk, Fred Mast,Andrew Simmonds, Richard Rachubinski. Cell Biology,University of Alberta, Edmonton, Alberta, Canada.

415AA Drosophila Model of High Fat Diet Induced Obesity andCardiovascular Disease. Ryan T. Birse1, Rolf Bodmer2, SeanOldham1. 1) Cancer Research Center, The Burnham Institutefor Medical Research, La Jolla, CA; 2) Development AgingProgram Burnham Institute for Medical Research, La Jolla, CA.

416BA Drosophila model of Type I Diabetes. Michael Z. Ludwig1,Soo-Young Park2, Honggang Ye2, Natalia A. Tamarina2,Graeme Bell2, Martin Kreitman1. 1) Dept Ecology Evolution,Univ Chicago, Chicago, IL; 2) Dept Medicine, Univ Chicago,Chicago, IL.

417CA microRNA, miR-7, is a Modifier of Tau-InducedNeurodegeneration. Surendra S. Ambegaokar1, George R.Jackson2. 1) Neuroscience IDP, Brain Research Institute, Centerfor Neurobehavioral Genetics, David Geffen School of Medicine,UCLA, Los Angeles, CA; 2) Depts of Neurology, NeuroscienceCell Biology, Biochemistry Molecular Biology, Mitchell Centerfor Neurodegenerative Diseases, The University of Texas MedicalBranch, Galveston, TX.

418AThe role of Microtubule Associate Proteins in progressiveneurodegeneration. Bonnie J. Bolkan, Doris Kretzschmar.CROET, Oregon Health and Science University, Portland, OR.

419BIdentifying members of the genetic circuitry associated with aDrosophila model of Spinal Muscular Atrophy. Douglas Dimlich,Anindya Sen, Takakazu Yokokura, Howard Chang, VasanthiSridhar, Tudor Fulga, David Van Vactor, Spyros Artavanis-Tsakonas. Dept. of Cell Biology, Harvard Medical School,Boston, MA.

420CReduced expression of the fly ortholog of human ALS candidateTDP-43 results in degeneration of the retina, suggesting aneuroprotective role. Dennis J. Hazelett, Wendy Timmermans,David B. Morton. Integrative Biosciences, OHSU, Portland, OR.

421AS. venezualae byproduct induces Parkinsonian symptoms andloss of dopaminergic neurons by stimulating neuroinflammatoryresponse in Drosophila. Arati A. Inamdar, Kim A. Caldwell,Guy A. Caldwell, Janis O'Donnell. Dept Biological Sci, UnivAlabama, Tuscaloosa, AL.

422BRetinal degeneration of a Drosophila ninaE mutant is suppressedby genes involved in ER Associated Protein Degradation. Min-Ji Kang, Hyung Don Ryoo. Dept Cell Biol, New York Univ SchMed, New York, NY.

423COver-expression of the vesicular monoamine transporter reducesoxidative stress in a Drosophila. H. O. Lawal, A. Terrell, H.-Y.Chang, D. Krantz. Psychiatry and Biobehavioral Sciences, UnivCalifornia, Los Angeles, Los Angeles, CA.

424AThe PINK1-Parkin pathway is involved in mitochondrialremodeling in Drosophila. Nhuong Van Nguyen, Jeehye Park,Jongkyeong Chung. National Creative Research InitiativesCenter for Cell Growth Regulation and Department of BiologicalSciences, KAIST (Korea Advanced Institute of Science andTechnology), 373-1 Guseong-dong, Yuseong-gu, Daejon 305-701, Korea.

425BDrosophila agnostic locus as approach to a study of the signalcascade of actin remodeling. Ekatherina Nikitina, AnnaMedvedeva, Dmitriy Molotkov, Elena Savvateeva-Popova.Dept. of Neurogenetics, Pavlov Inst. of Physiology, St. Petersburg,Russian Federation.



426CNew alleles affecting the Na/K ATPase alpha model familialhemiplegic migraines (FHM) and rapid-onset DystoniaParkinsonism (RDP) and implicate sodium pump impairment inincreased longevity. Michael J. Palladino1, Stacy Hrizo1, SarahPaul2, Wayne Van Voorhies3, Greg Beitel2, Lesley Ashmore1.1) Pharmacology Chem. Bio., Univ. of Pittsburgh, PA; 2) BMBCBNorthwestern University, Evanston, IL; 3) Molecular BiologyProgram, New Mexico State University, Las Cruces.

427AThe role of Prp31 in Drosophila eye development: Insights intomechanism of retinitis pigmentosa. Payal Ray, Jane Y. Wu.Department of Neurology, Northwestern University, Chicago, IL.

428BSequence-dependent Prion Protein conversion: lessons fromrabbits, mice and hamsters. Diego E. Rincon Limas1, MarcoMorales-Garza1, Sergio Casas-Tinto1, Yan Zhang1, MelisaGomez-Velazquez1, Wen-Quan Zou2, Pedro Fernandez-Funez1. 1) Dept Neurology, UTMB, Galveston, TX; 2) CaseWestern Reserve University, Cleveland, OH.

429CQuinone-based small molecules inhibit aggregation ofAlzheimer's disease-associated β-amyloid peptide (Aβ) andalleviate its effects in Drosophila. Daniel Segal, Roni Scherzer,Michal Levy, Anat Frydman-Marom, Ehud Gazit. MolecularMicrobiol Biotech, Tel Aviv Univ, Tel Aviv, Israel.

430AMetals impair locomotion activity in Drosophila melanogaster:A model to study movement disorders. C. Velez-Pardo, A. Daza-Restrepo, M. Jimenez-Del-Rio. University of Antioquia,Medellin, Colombia Calle 62#52-59, SIU-Building 1, Room 411/412, Medellin.

431BSwiss Cheese, a non-canonical regulator of Protein Kinase A,adopts a novel function when bound by OrganophosphatePesticides. Jill S. Wentzell, Alexandre Bettencourt da Cruz,Doris Kretzschmar. Oregon Health Science University, Portland,OR.

432CGene expression analysis after short term intermittent orconstant hypoxia in Drosophila melanogaster. Priti Azad1, DanZhou1, Erilynn Russo1, Gabriel Haddad1,2. 1) Dept Pediatrics,Univ California, San Diego, La Jolla, CA; 2) The Rady Children'sHospital, San Diego, CA 92123, USA.

433AAnalysis of Anthrax toxins activities in Drosophila. Beatriz Cruz-Moreno1, Annabel Guichard1, Shauna Mc Gillivray2, Nina VanSorge2, Victor Nizet2, Ethan Bier1. 1) Section of Cell andDevelopmental Biology, UCSD, La Jolla, CA; 2) Department ofPediatrics, UCSD, La Jolla, CA.

434BA Drosophila homologue of human multidrug resistance-associated protein 4 (MRP4), CG14709, is crucial for the viabilityof Drosophila under hypoxic and oxidative stresses. He Huang1,Ying Lu-Bo1, Gabriel Haddad1,2. 1) University of California, SanDiego, La Jolla, CA; 2) Rady Children's Hospital of San Diego,La Jolla, CA.

435Cdtorsin, a Drosophila homolog of early-onset dystonia DYT1, isrequired for the brain commissure formation of the twohemispheres in larvae. Naoto Ito1, Mamoru Yamanishi2, KristinCarney2, Nicole Smith1, Jo-Chen Chou1, Vijaya Ramesh1,Hideaki Moriyama2, James Gusella1, Noriko Wakabayashi-Ito1. 1) CHGR, Massachusetts General Hosp, Boston, MA; 2)School of Biological Science, University of Nebraska-Lincoln,Lincoln NE 68588.

436ACharacterization of modifiers of Dystrophin-Dystroglycancomplex-dependant muscular dystrophy in Drosophila. MariyaM. Kucherenko1,2, Andriy S. Yatsenko1, Wolfgang Nelle1,Halyna R. Shcherbata1. 1) Gene Expression and Signalinggroup, Institute for Biophysical Chemistry, Goettingen, Germany;2) Lviv National University, Lviv, Ukraine.

437BA Drosophila model for NF-κB mediated acute and chronicinflammation. Indira Paddibhatla, Roberto Ferrarese, MartaE. Kalamarz, Mark Lee, Tamara Goncharuk, Shubha Govind.The City College and The Graduate Center of The City Universityof New York, Department of Biology, 138th Street and ConventAvenue, New York, NY 10031, USA.

438CThe role of myotubularin phosphoinositide phosphatase in muscleremodeling and maintenance. Ines Ribeiro, Amy Kiger. DivBiological Sciences, Univ California, San Diego, La Jolla, CA.

439AThe influence of some genes modificators on the Dystrophingene functions in Drosophila melanogaster. V. M. Rishko, O. V.Poberezhnyk, V. E. Dishodze, N.Ya. Holub, D. V. Maksymiv,Ya. I. Chernyk. Genetic and Biotechnology, Ivan Franko NationalUniversity of Lviv, Lviv, Ukraine.

440BInvestigating the pathogenesis mechanism of IBMPFD inDrosophila. Tzu-Kang Sang, Yun-Ching Chang, Wen-TzuHung, Yin-Il Lin. Institute of Biotechnology and the Departmentof Life Sciences, National Tsing Hua Univ, Hsinchu, Taiwan.

441CAntimicrobial peptides protect against oxidant stress inDrosophila melanogaster. Huiwen W. Zhao1, Dan Zhou1, StevenA. Wasserman2, Victor Nizet1,3, Gabriel G. Haddad1,4. 1)Department of Pediatrics (Divisions of Respiratory Medicine;Infection Disease and Pharmacology and Drug Discovery); 2)Section of Cell and Developmental Biology; 3) the Skaggs Schoolof Pharmacy and Pharmaceutical Sciences, University ofCalifornia, San Diego; 4) Rady Childrens Hospital-San Diego.

442AMechanism of Metabolic suppression in Drosophilamelanogaster under Long-term Hypoxia. Dan Zhou1, Jin Xue1,Kevin White3, Gabriel Haddad1,2. 1) Dept Pediatrics, UnivCalifonia, San Diego, La Jolla, CA; 2) Rady Children's Hospital- San Diego, San Diego, California; 3) Departments of HumanGenetics and Ecology and Evolution, The University of Chicago,Chicago, Illinois.



443BUncoupling global and tissue-specific functions of Survival ofMotor Neuron (SMN) in vivo. Kavita Praveen, T. K. Rajendra,A. Gregory Matera. Dept Biology, Univ North Carolina, ChapelHill, NC.

444CUnderstanding the relationship between cell-essential and tissue-specific functions of the survival motor neuron protein. T. K.Rajendra, Kristin M. Morrison, A. Gregory Matera. DeptBiology, Univ North Carolina, Chapel Hill, NC.

Evolution and Quantitative Genetics

445AElucidating the evolutionary mechanisms of pigmentationdifferences between Drosophila species. Lisa Arnold, LauraShefner, Yainna Hernaiz-Hernandez, Adam Neidert, PatriciaWittkopp. MCDB, University of Michigan, Ann Arbor, MI.

446BInsect flight evolution: a multi-protein, multi-step process. AgnesJ. Ayme-Southgate, Debbie Griffith, George Miller. Dept Biol,Col Charleston, Charleston, SC.

447CInsect flight evolution, calcium cycling and calcium ATPase pump.Agnes J. Ayme-Southgate, Catherine Gumps. Dept Biol, ColCharleston, Charleston, SC.

448AHow do insects fly: bioinformatics analysis of projectin, amyofibrillar protein. Agnes J. Ayme-Southgate, Richard J.Southgate, Drew Philipp, Jeff Jankowski. Dept Biol, ColCharleston, Charleston, SC.

449BGenome-wide analysis of evolution of transcriptional regulationin embryonic development of Drosophilids. Karolina M.Jastrzebowska, Stephan M. Preibisch, Pavel Tomancak. MaxPlanck Institute of Molecular Cell Biology and Genetics, Dresden,Germany.

450CConserved role of the JH-response genes Met and Kr-h1 inholometabolous and hemimetabolous metamorphosis. B.Konopova, M. Jindra. Biology Center ASCR, Ceske Budejovice,Czech Republic.

451AHead expression profiles in Drosophila reveal female-biasedpatterns of gene expression and no pattern of chromosomedistribution. John Malone, Brian Oliver. LCDB, NIDDK, NIH,Bethesda, MD, 20892.

452BGenetic Analysis of Intra- and Interspecific Sex Comb Variationin the Drosophila bipectinata Species Complex. Chen SiangNg, Olga Barmina, Artyom Kopp. Department of EvolutionEcology and Center for Population Biology, University ofCalifornia - Davis, Davis, CA 95616, USA.

453CMany ways to be small: Different environmental regulators ofsize generate different scaling relationships in Drosophila.Alexander Shingleton, Chad Estep, Michael Driscoll, IanDworkin, PURL. Department of Zoology, Michigan StateUniversity, East Lansing, MI.

454ANegative correlation between the distribution of polymorphicduplications and deletions across the Drosophila melanogastergenome. Margarida Cardoso-Moreira1,2,3, Manyuan Long1. 1)Dept Ecology Evolution, Univ Chicago, Chicago, IL; 2) Faculdadede Ciências, Univ Porto, Porto, Portugal; 3) Graduate Programin Areas of Basic and Applied Biology, Univ Porto, Porto, Portugal.

455BJY-alpha, a gene involved in hybrid incompatibility, is part of theancestral Drosophila Y-chromosome. Bernardo Carvalho1,Andrew Clark2. 1) Dept de Genetica, Universidade Federal doRio de Janeiro, Rio de Janeiro, Brazil; 2) Molecular Biology andGenetics, Cornell University.

456CMolecular evolution and functional diversification of fatty aciddesaturases after recurrent gene duplication in Drosophila. S.Fang1, C.-T. Ting2,3, C.-R. Lee1, K.-H. Chu3, C.-C. Wang1, S.-C.Tsaur1. 1) Biodiversity Research Center, Academia Sinica,Taipei, Taiwan, ROC; 2) Department of Life Science Institute ofEcology and Evolutionary Biology, National Taiwan University,Taipei, Taiwan, ROC; 3) Institute of Zoology, National TaiwanUniversity, Taipei, Taiwan, ROC.

457ANon-random protein evolution within the genus Drosophila.Donal A. Hickey. Dept Biol, Concordia Univ, Montreal, PQ,Canada.

458BProtein-coding Ultraconserved elements are targets of RNAediting. Andrew D. Kern. Biological Sciences, DartmouthCollege, Hanover, NH.

459CRNA-seq quantitation of sex-biased gene expression inDrosophila willistoni. Richard Meisel, Andrew Clark. Dept MolecBiol Genetics, Cornell Univ, Ithaca, NY.

460AEvolution of Embedded and Overlapping Genes in Drosophila.Stephen W. Schaeffer. Dept Biol, Pennsylvania State Univ,University Park, PA.

461BRepetitive DNA and evolutionary plasticity of the malariamosquito genome. Igor V. Sharakhov1, Ai Xia1, Maria V.Sharakhova1, Scotland Leman2, Zhijian Tu3. 1) DeptEntomology, Virginia Tech, Blacksburg, VA; 2) Dept Statistics,Virginia Tech, Blacksburg, VA; 3) Dept Biochemistry, VirginiaTech, Blacksburg, VA.

462CMolecular evolution of testes-specific βNACtes genes in severalDrosophila species. Lev A. Usakin, Vladimir A. Gvozdev. AnimalMolecular Genetics, Inst Molecular Genetics, Moscow, Russia.



463AX Chromosome Inactivation Caused Demasculinization. LiZhang, Gao Ge. Center for Bioinformatics, Peking University,Peking, China.

464BAcp36DE mediates the uterine conformational changes requiredfor efficient sperm storage. Frank W. Avila, Mariana F. Wolfner.Dept Mol Biol Gen, Cornell Univ, Ithaca, NY.

465CIdentification and analysis of serpin-family transcripts byhomology and synteny across the 12 sequenced Drosophilidgenomes. Ane Fullaondo1, Matthew Garret2, Gos Micklem1,David Gubb2. 1) Functional Genomics, CICbioGUNE, Derio,Bizkaia, Spain; 2) Department of Genetics, Cambridge University,UK.

466ARNA editing of P element transcripts in an M strain of Drosophilamelanogaster. Masanobu Itoh1,2, Tomokazu Fukui3. 1) DeptApplied Biol, Kyoto Inst Tech, Kyoto, Japan; 2) Insect BiomedicalResearch Center, Kyoto Inst Tech, Kyoto, Japan; 3) VentureLaboratory, Kyoto Inst Tech, Kyoto, Japan.

467BEvolution of the promotor region of the Ras1 gene in D. virilisspecies group. Anna I. Chekunova, Alex M. Kulikov, Oleg E.Lazebny, Vladimir G. Mitrofanov. Dept Genetics, Koltsov InstDev Biol, RAS, Moscow, Russian Federation.

468CEvolution of α glycerophosphate dehydrogenase and αglycerophosphate oxidase paralogs in the genus Drosophila.Ross J. MacIntyre, Amber Carmon. Dept Molec Biol and Gen,Cornell Univ, Ithaca, NY.

469APopulation Variation and Divergence Along the FourthChromosome in D. yakuba, D. simulans, and D. melanogaster.J. Roman Arguello1, Tomoyuki Kado2, Wen Wang3, HidekiInnan2, Manyuan Long4. 1) Molecular Biology and Genetics,Cornell, Ithaca, NY, USA; 2) Hayama Center for AdvancedStudies, The Graduate University for Advanced Studies,Kanagawa, Japan; 3) Kunming Institute of Zoolog, Kunming,China; 4) University of Chicago, Chicago, IL, USA.

470BModulation of CRAMPED interactions by natural variation. Jean-Michel Gibert1, Christian Schlötterer2, Rob Maeda1, FrancoisKarch1. 1) University of Geneva, Geneva, Switzerland; 2)Veterinary University of Vienna, Vienna, Austria.

471CNatural variation in metabolic function. Anthony J. Greenberg1,Sean R. Hackett1, Lawrence Harshman2, Andrew G. Clark1.1) Dept Molec Biol Genetics, Cornell Univ, Ithaca, NY; 2) Deptof Biological Sciences, Univ. of Nebraska, Lincoln, NE.

472ATransposable element insertions into Drosophila heat-shockpromoters: distribution and effects. Robert A. Haney, Arwyn S.Schumacher, Martin E. Feder. Dept Organismal BiologyAnatomy, University of Chicago, Chicago, IL.

473BPopulation genetics of Eater, an recognition molecule thatpromotes phagocytosis by the cellular immune response. PunitaJuneja, Brian Lazzaro. Department of Entomology, CornellUniversity, Ithaca, NY.

474COvulin Processing in Mated Female D. melanogaster: Role ofSeminal Proteins and Natural Variation. Brooke A. LaFlamme1,Ravi Ram Kristipati1, Jason G. Mezey2, Mariana F. Wolfner1.1) Molecular Biology Genetics, Cornell Univ, Ithaca, NY; 2)Biological Statistics Computational Biology, Cornell Univ, Ithaca,NY.

475AFunctional consequences of adaptive sequence variation at thehistone remodeling gene, chameau, in Drosophila melanogaster.Mia Tauna Levine, Melissa Eckert, Elizabeth Milano, DavidBegun. Dept Evolution Ecology, Univ California, Davis, Davis,CA.

476BTranscriptional regulation of metabolism associated with theincreased desiccation resistance of the cactophilic Drosophilamojavensis. Luciano M. Matzkin, Therese A. Markow. Ecology,Behavior and Evolution, University of California, San Diego, LaJolla, CA.

477CAre nuclear transport retrogenes convergently recruited forsegregation distortion functions in Drosophila? Mansi Motiwale,Charles Tracy, Xavier Río, Shawn Christensen, Esther Betrán.UTA, Arlington, TX.

478AEpistasis in the Drosophila yolk protein expression network.Aaron Tarone1, Lauren McIntyre2, Sergey Nuzhdin1. 1) MolComputational Biol Prog, Univ Southern California, Los Angeles,CA; 2) 2Genomics Institute, Dept. of Statistics, Dept. of MolecularGenetics and Microbiology, University of Florida, Gainesville,FL.

479BClusters of mutation, linkage disequilibrium and adaptations.Ronny C. Woodruff, Mingcai Zhang. Dept Biol Sci, BowlingGreen State Univ, Bowling Green, OH.

480CSigma virus and male fertility in Drosophila melanogaster. TracyCassagnol, Marta Wayne. Zoology, University of Florida,Gainesville, FL.

481AGenetic mapping of evolved differences in pupariation sitepreference between two closely related species of Drosophila.Deniz F. Erezyilmaz, David L. Stern. Ecology and EvolutionaryBiology, Princeton University, Princeton, NJ.

482BGeneration of quantitative variation in wing vein phenotypes inD. melanogaster by the Hedgehog and Decapentaplegicsignalling pathways. James Lorigan, Jason Mezey, FangfeiYe. Dept Biological Statistics, Cornell Univ, Ithaca, NY.



483CA resource for the genetic analysis of complex traits in Drosophila.Stuart J. Macdonald1, Anthony D. Long2. 1) Dept. MolecularBiosciences, University of Kansas, Lawrence, KS; 2) Dept.Ecology Evolutionary Biology, University of California, Irvine, CA.

484AMito-nuclear epistasis for desiccation, locomotor and thermaltraits in Drosophila. David M. Rand, S. Le, N. Jourjine, K. L.Montooth, C. D. Meiklejohn. Ecology Evolutionary Biol, BrownUniv, Providence, RI.

485BGenetical Toxicogenomics in Drosophila Identifies MasterModulatory Loci that are Regulated by Developmental Exposureto Lead. Douglas M. Ruden, Parsa Rasouli, Wang Luan. IEHS,Wayne State Univ, Detroit, MI.

486CDominance to Additive Ratio for New Mutations for OvarioleNumber in Drosophila melanogaster. Lyvie-Sara Sylvestre,Michele Edison, Marta L. Wayne. University of Florida,Gainesville, FL.

487ASingle fly behavior in lines of Drosophila selected for extremegeotaxis behavior. D. P. Toma, J. Perlich, C. Talyor, E. Wreh.Dept Biological Sci, Minnesota State Univ, Mankato, MN.

488BCopia transposable element: host silencing mechanism. WendyVu. Molecular and Computational Biology, University of SouthernCalifornia, Los Angeles.

489CA "tail" of two flies: the genetic basis of interspecific differencesin abdominal pigmentation. M. Margarita Womack1, MarkRebeiz2, Nicolas Frankel1, Andrew Hanna3, David Stern1,Peter Grant1. 1) Ecology Evolutionary Biology, PrincetonUniversity, Princeton, NJ; 2) R.M. Bock Laboratories, Universityof Madison-Wisconsin, WI; 3) John Innes Centre, Norwhich,Norfolk, UK.

490APartial behavioral isolation between DDT resistant populationsand their unselected controls under long term selection andisolation in Drosophila melanogaster. Phillip T. Barnes, JazlenSamboy, Kylee Yam. Biology Department, Connecticut Colllege,New London, CT 06320.

491BHeterochromatin as a facilitator of speciation: an incompatibilitybetween a satellite and its associated binding protein causeshybrid lethality in Drosophila. Patrick M. Ferree, Daniel A.Barbash. Dept . of Molecular Biology and Genetics, CornellUniversity, Ithaca, NY.

492CQuantitative patterns of CHC expression and divergent matechoice due to Reproductive Character Displacement inDrosophila serrata. Brad R. Foley1, Stephen F. Chenoweth2,Mark W. Blows2. 1) Molecular Cell Biol, Univ Southern California,Los Angeles, CA; 2) School of Integrative Biology, University ofQueensland, Queensland, Australia.

493AThe genetics of male mate choice in Drosophila simulans andD. sechellia. Jennifer M. Gleason, Leanna M. Birge, FaithIghoyivwi, Brian J. Sanderson. Ecology and EvolutionaryBiology, University of Kansas, Lawrence, KS.

494BWhen Genomes Collide: Microarray expression profiledifferences underlying female hybrid sterility in Drosophila. HopeHollocher, Heather Eisler, Jeanne Romero-Severson.Department of Biological Sciences, University of Notre Dame,Notre Dame, IN.

495CInvestigating Transmission Distortion in Interspecies Hybrids.Scott A. Kerr1, Josh J. Bayes1,2, Danielle Vermaak1, Harmit S.Malik1. 1) Basic Sciences, Fred Hutchinson Cancer ResearchCenter, Seattle, WA; 2) MCB Program, UW, Seattle, WA.

496APossible role of bottlenecks in the evolution of the D. virilis speciesgroup. Alex M. Kulikov, Oleg E. Lazebny. Dept Genetics, KoltsovInst Dev Biology/RAS, Moscow, Russian Federation.

Gametogenesis and Organogenesis

497BMTOC translocation controlled by a two steps process isessential for tracheal cell morphogenesis. Antoine Guichet1,Alexandre Baffet1, Jordi Casanova2, Véronique Brodu1. 1)IJM, CNRS, Paris, France; 2) IBMB, Barcelona,Spain.

498CIdentification and Characterization of Genes Involved inFormation of a Branched Cell. Tiffani A. Jones, Mark M.Metzstein. Human Genetics, University of Utah, Salt Lake City,UT.

499Apolished rice, a versatile gene regulator in Drosophiladevelopment. Yuji Kageyama1,2,3, Yoshiko Hashimoto1,2,3,Takefumi Kondo2,4. 1) Okazaki Institute for IntegratedBioscience, National Institutes of Natural Sciences, Okazaki,Aichi 444-8787, Japan; 2) National Institute of Basic Biology,National Institutes of Natural Sciences, Okazaki, Aichi 444-8787,Japan; 3) PRESTO, Japan Science and Technology Agency; 4)Japan Sociey for the Promotion of Science.

500BThe Drosophila Fox Family of Transcriptional Regulators: Tissuespecific expression and gene regulation. Rika Maruyama,Elizabeth Grevengoed, Peter Stempniewicz, Urania Ng,Deborah Andrew. Dept Cell Biol, Johns Hopkins Sch Med,Baltimore, MD.

501CInvestigating the Function of Ets domain Transcription Factorsin Tracheal Development. Sam S. M. T. Maung, Monn M. Myat.Weill Medical College of Cornell University, New York, NY.

502ACharacterization of salivary gland migration mutants. UnishaB. Patel, Monn Monn Myat. Dept Cell Developmental Biol, WMCof Cornell Univ, New York, NY.



503BActivated Pak1 transforms a single central lumen into multipleintercellular lumens through endocytosis of E-cadherin. CarolynPirraglia, Jenna Walters, Monn Monn Myat. CellDevelopmental Biology, Weill Medical College of CornellUniversity, New York, NY.

504CMultipotent progenitors remodel the Drosophila abdominalairways. Chrysoula Pitsouli1, Norbert Perrimon1,2. 1) GeneticsDept, Harvard Medical Sch, Boston, MA; 2) Howard HughesMedical Institute.

505AThe role of Zpr1 in tracheal terminal cell lumen formation. OscarE. Ruiz, Mark M. Metzstein. Dept Human Genetics, Univ Utah,Salt Lake City, UT.

506BThe role of the bHLH transcription factor, Hairy, in tracheal tubeformation. Yaoyao Zhan, Bing Shao, Monn Monn Myat. Celland Developmental Biology, Weill Medical College of CornellUniversity, New York, NY.

507CDumpy nonsense mutants and their role in alternative splicing.Amber Carmon1, Olga Grushko2, Ross MacIntyre1. 1) DeptMolec Biol and Genetics, Cornell Univ, Ithaca, NY; 2) Institute ofLife Sciences, Univ Michigan, Ann Arbor, MI.

508ADrosophila Src as an effector of the Na,K-ATPase in trachealtube size control. Kevin Nelson, Greg Beitel. BMBCB,Northwestern Univ, Evanston, IL.

509BToward a molecular genetic analysis of epithelial morphogenesisin Drosophila leg imaginal discs: characterization of theexpression and loss-of-function phenotypes of RhoGEFs andRhoGAPs in pupariating leg discs. Lina Greenberg, StevenDelSignore, Victor Hatini. Anatomy Dept, Tufts UniversitySchool of Medicine, Boston, MA.

510CDpp signaling promotes the cuboidal to columnar cell shapetransition of Drosophila wing disc epithelia through regulatingRho1. T. J. Widmann, C. Dahmann. Max Planck Institute ofMolecular Cell Biology and Genetics, Dresden, Germany.

511ACharacterization of temperature sensitive Mef2 mutants inDrosophila. Melanie Adams, Tyanna Lovato, Phillip W. Baker,Richard M. Cripps. Biol, Univ New Mexico, Albuquerque, NM.

512BFly Muscle LIM Protein, Mlp84B, cooperates with Salimus tomaintain muscle integrity. Kathleen A. Clark, Mary C. Beckerle.Huntsman Cancer Institute and Dept. of Biology, University ofUtah, Salt Lake City.

513CIdentification of Mechanisms Regulating Muscle Size and Shape.Krista C. Dobi, Ming-Ching Wong, Mary K. Baylies.Department of Developmental Biology, Sloan-Kettering Institute,New York, NY.

514AA genetic screen for hematopoietic control factors. Cory J.Evans, Amir Yavari, Bama Mondal, Julia Manasson, SeanMofidi, Utpal Banerjee. Dept MCD Biol, Univ California, LosAngeles, Los Angeles, CA.

515BAdult founder cells regulate myoblast proliferation and fibernumber in Drosophila. Joyce J. Fernandes, Badrinath Krishan.Zoology Dept, Miami Univ, Oxford, OH.

516CElucidating the role of the SH3 adapter protein CD2AP/Cindr inmyoblast fusion in DrosItalic Textophila. Shruti Haralalka, SusanM. Abmayr. Stowers Institute. 1000E 50th St, Kansas City. MO.64114.

517ABithorax Complex genes control alary muscle patterning alongthe cardiac tube of Drosophila. Elisa M. LaBeau, Damian L.Trujillo, Richard M. Cripps. Department of Biology,Albuquerque, NM.

518BAltered arrangements: Imaging analysis of myoblast cellularbehaviors during Drosophila myogenic fusion. Kate MelissaRochlin1, Karen Beckett2, Brian Richardson1. 1) DeptDevelopmental Biol, Sloan-Kettering Inst, New York, NY; 2)Medical Research Council National Institute of MedicalResearch, Mill Hill, London.

519CSex-lethal facilitates the transition from germline stem cell tocommitted daughter cell in the Drosophila ovary. Johnnie Chau,Laura Shapiro Kulnane, Helen K. Salz. Department ofGenetics, Case Western Reserve University, Cleveland, OH.

520AQuantitative analysis of follice cell morphogenesis in theDrosophila eggchamber. Anne-Kathrin Classen1, Peter F.White2, Daniel M. Shreter2, Kevin S. Kolahi2, David Bilder1,Mohammad R. K. Mofrad2. 1) Department of Molecular andCell Biology, University of California at Berkeley; 2) Departmentof Bioengineering, University of California at Berkeley.

521BRegulating translation of maternal messages by wispy, a GLD-2-type cytoplasmic poly(A) polymerase in Drosophilamelanogaster. Jun Cui, Mariana Wolfner. Department ofMolecular Biology and Genetics, Cornell University, Ithaca, NY.

522COpposing interactions between Cut and Slow Border Cells directapical constriction and epithelial invagination during centripetalmigration. L. Dobens, B. Levine, J. Hackney, A. Truesdale, L.Dobens III, A. Bergen. School of Biological Sciences, Universityof Missouri-Kansas City, Kansas City, MO.

523AEna promotes maintenance of ring canal structure in late stageegg chambers. Julie Gates, Cristina Herrera, Stephanie L.Sottile. Biology, Bucknell Univ, Lewisburg, PA.



524BCongression of achiasmate chromosomes to the metaphaseplate in Drosophila melanogaster oocytes. William D. Gilliland1,Stacie E. Hughes1, Dana R. Vietti1, R. Scott Hawley1,2. 1)Stowers Inst, Kansas City, MO. 64110 USA; 2) Department ofPhysiology, University of Kansas Medical Center, Kansas City,KS 66160 USA.

525CEndos-Elgi interaction and its role in oocyte meiotic maturation.Min-Young Kim, Daniela Drummond-Barbosa. Cell andDevelopmental Biology, Vanderbilt University Medical Center,Nashville, TN.

526ADisruption of oogenesis by mutations in drop-dead (drd). LauraE. Korthauer, Edward M. Blumenthal. Biological Sciences,Marquette University, Milwaukee, WI.

527BRegulation of Vasa by Gustavus and Wallenstein. Jan-MichaelKugler1, Jae-Sung Woo2, Byung-Ha Oh2, Paul Lasko1. 1) Dept.of Biology, McGill University, Montreal, QC, Canada; 2) Dept. ofLife Sciences, Pohang University, Pohang, Korea.

528CTOR mediates the ovarian response to diet via cell autonomousand non-cell autonomous mechanisms. Leesa LaFever,Alexander Feoktistov, Daniela Drummond-Barbosa. Cell andDevelopmental Biology, Vanderbilt University Medical Center,Nashville, TN.

529AIdentification of RNA targets of the RNA-binding protein Larkduring oogenesis using a microarray-based Ribonomicsapproach. Gerard P. McNeil, Sheryl Purrier, Manpreet Kaur,Ruth Kang. Dept Biol, York Col/CUNY, Jamaica, NY.

530BIdentification of stem cells regulators in the Drosophila ovary.Laura Ponting1, Ged Brady2, Martin Baron1. 1) Faculty LifeSci, Univ Manchester, Manchester, United Kingdom; 2) EpistemLtd. 48 Grafton Street Manchester M13 9XX United Kingdom.

531CPolarized protein movements are affected by environmentalstress in Drosophila egg chambers. Yuko Shimada, K. MahalaBurn, Lynn Cooley. Department of Genetics, Yale UniversitySchool of Medicine, New Haven, CT.

532AInvestigating the Role of Myb in Drosophila Oogenesis. HeatherStalker, Joseph Lipsick. Departments of Genetics andPathology. Stanford University, Stanford, CA.

533BIdentification of Sosie as a novel putative EGF domain proteinrequired for Drosophila oogenesis. Olivier Urwyler, Beat Suter.Institute of Cell Biology, University of Bern, Bern, Switzerland.

534CUse of endogenous disulfide bonds to investigate the assemblyof protein networks within the vitelline membrane. Tianyi Wu, GailWaring. Dept Biological Sci, Marquette Univ, Milwaukee, WI.

535AExpression and regulation of cadherin genes in Drosophilaoogenesis. Jeremiah Zartman1, Miriam Osterfield1, JitendraKanodia1, Karin Schlichting2, Nir Yakoby1, ChristianDahmann2, Stanislav Shvartsman1. 1) Lewis Sigler Instituteand Department of Chemical Engineering, Carl Icahn Laboratory,Princeton University, Princeton, NJ; 2) Max Planck Institute ofMolecular Cell Biology and Genetics, Dresden, Germany.

536BSMRTER, a transcriptional corepressor of EcR, is involved inDrosophila oogenesis. Bin Zhang. Dept Physiology, Universityof Medicine and Dentistry of New Jersey, Piscataway, NJ.

537CIsolation of mutants defective for epithelial morphogenesis duringDrosophila early embryonic development. T. C. Ferreira, A. Rosa,P. Prudêncio, R. Martinho. Instituto Gulbenkian de Ciência,Oeiras, Portugal.

538AProteomic Studies of Egg Activation in Drosophila melanogaster.Amber R. M. Krauchunas1, Vanessa L. Horner2, Mariana F.Wolfner1. 1) Department of Molecular Biology and Genetics,421 Biotechnology Building, Cornell University, Ithaca, NY 14853;2) Department of Human Genetics, Whitehead BiomedicalResearch Building, 615 Michael Street, Suite 301, Atlanta, GA30322.

539BComparative Analysis of Post-mating Changes in the FemaleReproductive Tract. P. K. Rivlin1, A. Kalpenikov2, I. Carmel2, R.R. Hoy1, Y. Heifetz2. 1) Dept. of Neurobiology and Behavior,Cornell Univ., Ithaca, NY; 2) Dept. Entomology, Hebrew Univ.,Rehovot, Israel.

540CSNS and Duf direct adhesion and fusion in the development ofthe garland cell nephrocytes in the Drosophila embryo. ShufeiZhuang, Huanjie Shao, Susan M. Abmayr. Stowers InstMedical Research, Kansas City, MO.

541ATudor localization and stability in pole plasm. Joel Anne, BernardM. Mechler. Dept Developmental Genetics, Alliance DKFZ-ZMBH, Heidelberg, Germany.

542BFinding targets of the sex determination transcription factor DSXby combining expression profiles, occupancy and computationalapproaches. Leonie Ulrike Hempel, David Sturgill, Yu Zhang,Brian Oliver. LCDB/NIDDK/NIH, Bethesda, MD.

543CJAK/STAT regulation of germ cell sex determination. GretchenH. McConnell, Carla Wood, Matthew Wawersik. Dept Biol,College William Mary, Williamsburg, VA.

544AThe secretory cells of the spermathecae are essential for multiplereproductive functions and reveal a female mating-responsivepathway independent of the sex peptide receptor. Sandra L.Schnakenberg, Mark L. Siegal. Department of Biology, Centerfor Genomics and Systems Biology, New York University,New York, NY.



545BProteome Dynamics of Pre- and Post-Mating FemaleReproductive Organs in Drosophila melanogaster. NobuakiTakemori, Masa-Toshi Yamamoto. Dros Gen Resource Ctr,Kyoto Inst Tech, Kyoto, Japan.

546Cmitoshell, a novel gene required for mitochondrial aggregationand cytokinesis in Drosophila spermatogenesis, affects formationof the meiotic central spindle and the contractile ring. Laura M.Bergner, F. Eddie Hickman, Kathleen H. Wood, Sheena M.Favors, Amanda C. Aldridge, Karen G. Hales. Department ofBiology, Davidson College, Davidson, NC.

547Achinmo is a Stat92E target gene that regulates stem cell self-renewal in the Drosophila testis. Maria Sol Flaherty1, JiriZavadil2, Erika Bach1. 1) Pharmacology, New York UniversitySchool of Medicine; 2) Genomics Facility, New York UniversityCancer Institute, New York, NY.

548BRole of Piwi-Family Proteins in Segregation Distortion. SelenaL. Gell, Cynthia Staber, Robert Reenan. Department ofMolecular Biology, Cell Biology and Biochemistry, BrownUniversity, Providence, RI.

549CdWee1 is the G2/M timer whereas dMyt1 maintains cytoskeletalstructures during Drosophila spermatogenesis. Debolina GuhaMajumdar1, Zhigang Jin1,2, Shelagh Campbell1. 1) Department ofBiological Sciences, University of Alberta, Edmonton, AB, Canada;2) Stowers Institute for Medical Research, Kansas City, MO.

550AEnhancers of Segregation Distorter. Janna R. McLean, JenniferSmith, Hollie Vigil. Biology Department, Colorado StateUniversity - Pueblo, Pueblo, CO.

551BThe role of THO complex in Drosophila spermatogenesis:maintenance of nuclear integrity or nuclear mRNA export? S.Moon, J. Lee, Y. Chung. Department of Lifescience, Universityof Seoul, Korea.

552CMechanism of sperm morphogenesis in Drosophila: Roles ofcytoplasmic microtubule arrays in robustly elongating cell.Tatsuhiko Noguchi, Michiko Koizumi, Shigeo Hayashi.Morphogenetic Signaling, CDB, RIKEN, Kobe, Hyogo, Japan.

553ACharacterization of new genes required for sperm tail formationin Drosophila. Janet E. Rollins1, Lacramioara Fabian2, BarbaraWakimoto3, Julie Brill2. 1) Dept Sci, Col Mt Saint Vincent,Riverdale, NY; 2) Program in Developmental and Stem CellBiology, The Hospital for Sick Children, Toronto, ON; 3)Department of Zoology, University of Washington, Seattle WA.

554BA cytoplasmic poly-A polymerase is necessary forspermatogenesis in Drosophila. Caroline Sartain, Jun Cui,Mariana Wolfner. Department of Molecular Biology and GeneticsCornell University, Ithaca, NY.

555CPost-meiotic transcription in Drosophila spermatogenesis. MariaD. Vibranovski1, Hedibert F. Lopes2, Timothy L. Karr3,Manyuan Long1. 1) Ecology Evolution, Univ Chicago, Chicago,IL; 2) Graduate School of Business, Univ Chicago, Chicago, IL;3) Biodesign Institute, Arizona State University, Tempe, AZ.

556AThe sperm proteome footprint of Drosophila testis transcriptome.Maria D. Vibranovski1, Steve Dorus2, Manyuan Long1, TimothyL. Karr3. 1) Ecology Evolution, Univ Chicago, Chicago, IL; 2)Department of Biology and Biochemistry, University of Bath,Bath, UK; 3) Biodesign Institute, Arizona State University, Tempe,AZ.

Immunity and Pathogenesis

557BPallbearer, a Drosophila E3-Ubiquitin Ligase Promotes EfficientPhagocytosis of Apoptotic Cells. Nathalie C. Franc. TheDepartment of Genetics, The Scripps Research Institute, SanDiego, CA.

558CUndertaker, a Drosophila Junctophilin, Links Draper-MediatedPhagocytosis and Calcium Homeostasis. Nathalie C. Franc. TheDepartment of Genetics, The Scripps Research Institute, SanDiego, CA.

559AJAK/STATsignalling during larval hematopoieisis and the cellularimmune response to wasp parasitization. A. Vincent1, R. Makki1,J. Krzemien1, D. Pennetier1, J. Oyallon1, M. Meister2, M.Crozatier1. 1) Developmental Biology Unit, UMR 5547 CNRS/Univ. Toulouse III, France; 2) CNRS UPR 9022, Strasbourg,France.

560BThe Drosophila RhoGEF Zizimin-related is necessary for aproper cellular immune response. Michael J. Williams1,Christopher Sampson1, Marie-Odile Fauvarque2. 1) IBES,University of Aberdeen, Aberdeen, United Kingdom; 2) CEA,DSV, iRTSV/LTS, CEA-Grenoble, 17 rue des Maertyrs, Grenoble,F-38054, France.

561CGut bacteria shape Drosophila immune responses to pathogens.Nichole A. Broderick, Nicolas Buchon, Bruno Lemaitre. GHI,EPFL, Lausanne, Switzerland.

562AThe Drosophila gut response to bacterial infection. N. Buchon,N. A. Broderick, B. Lemaitre. Global Health Institute, EPFL,Lausanne, Vaud, Switzerland.

563BCross-Talk between the Insulin Signaling and Immune SystemPathways in Drosophila. I. Hansen1,2, S. Pletcher1,2,3. 1)Huffington Ctr on Aging, Baylor Col Medicine, Houston, TX; 2)Interdepartmental Program in Cell and Molecular Biology, BaylorCol of Medicine, Houston, TX; 3) Department of Molecular andHuman Genetics, Baylor Col of Medicine, Houston, TX.



564CMolecular biology and evolution of candidate anti-wasp immunereceptors in Drosophila. Erin S. Keebaugh1,2, Todd A.Schlenke1,2. 1) Population Biology, Ecology, Evolution Program,Emory Univ, Atlanta, GA; 2) Dept of Biology, Emory Univ, Atlanta,GA.

565AHypercapnia suppresses innate immune responses in Drosophila.Tomasz Krupinski1, Iiro Helenius1,2, Dennis Wang2, JacobSznajder2, Peter Sporn2, Greg Beitel1. 1) NorthwesternUniversity, Evanston, IL; 2) Northwestern University, Chicago, IL.

566BAlphavirus derived small RNAs modulate pathogenesis indisease vector mosquitoes. Kevin M. Myles, Michael R. Wiley,Elaine M. Morazzani, Zach N. Adelman. Dept Entomology,Virginia Tech, Blacksburg, VA.

567CSalmonella pathogenesis reveals that Dpp signaling regulatesblood cell homeostasis and immune responses in Drosophila.Stuart J. Newfeld1, Bronwyn Gunn2, Selen Muratoglu3, NancyFossett3, Joel L. Frandsen1. 1) School of Life Sciences, ArizonaState Univ, Tempe, AZ; 2) Center for Infectious Diseases andVaccinology, Arizona State Univ, Tempe, AZ; 3) Center forVascular and Inflammatory Diseases, University of Maryland,Baltimore MD.

568ADrosophila melanogaster and sigma virus. C. V. Nguyen, M. L.Wayne. Department of Botany and Zoology, University of Florida,Gainesville.

569BIdentification of a serpin required for regulation of Toll pathwayin Drosophila melanogaster. Ane Fullaondo, David Gubb, SoYoung Lee. Functional Genomics, CIC bioGUNE, Derio, Bizkaia,Spain.

570CDanger signal and PAMP sensing define binary signalingpathways upstream of Toll. Vincent Leclerc, Laure El Chamy,Isabelle Caldelary, Jean-Marc Reichhart. IBMC CNRSUPR9022, University of Strasbourg, Strasbourg, France.

571AThe regulation of shifted in Mycobacterium marinum-infectedDrosophila. Martina Yildirim, Marc Dionne. Department ofCraniofacial Development, King's College London, UnitedKingdom.

572BFood processing in Drosophila (or "Seal a Meal" Redux). RonDubreuil1, Shane Regnier2, Gloria Mazock1. 1) Dept BiologicalSci, University of Illinois at Chicago, Chicago, IL; 2) University ofIllinois at Urbana Champagn, Urbana, IL.

573CZfrp8 and lymph gland development. Svetlana Minakhina,William Tan, Ruth Steaward. Waksman Inst, Rutgers Univ,Piscataway, NJ.

574ACharacterizing Ets21c, a putative master regulator of tolerancein Drosophila melanogaster. Moria C. Chambers, DavidSchneider. Microbiology and Immunology, Stanford University,Stanford, CA.

575BSystems analysis of mycobacterial infection in Drosophila: findingnew regulators of immunity and pathogenesis. Marc S. Dionne,Rebecca Clark, Martina Yildirim. Dept CraniofacialDevelopment, King's College London, London, United Kingdom.

576CTranscriptional Regulation of eater Gene Expression inPlasmatocytes. Paul T. Kroeger, Tsuyoshi Tokusumi, JessicaR. Stoller, Robert A. Schulz. Department of Biological Sciences,University of Notre Dame, Notre Dame, IN. 46556. USA.

577AWolbachia bacteria overreplicate and localize to the CNS in wildpopulations of Drosophila simulans and melanogaster. RogerAlbertson. Albion College, Albion, MI.

578BStem cell niche tropism as a novel mechanism for Wolbachiatransmission. Kanchana Panaram, Eva Fast, BarrettSteinberg, Horacio Frydman. Biology, Boston University,Boston, MA.

Neural Physiology and Behavior

579CAggression, attraction, and the regulation of aggregation in D.melanogaster. Brad R. Foley1, Julia B. Saltz2, Sergey V.Nuzhdin1. 1) Molecular Cell Biol, Univ Southern California, LosAngeles, CA; 2) Population Biology, UC Davis, Davis, CA.

580AMapping and Functional Study of Phosphorylation sites of theDrosophila Circadian Clock Protein PERIOD. Yanshan Fang,Xiangzhong Zheng, Wen-Feng Chen, Amita Sehgal. DeptNeuroscience, HHMI, Univ Pennsylvania, Philadelphia, PA.

581BUsing fruit fly to dissect honeybee worker division of labor: Braingene expression markers of honeybee behavioral/social state(hive working vs. foraging) may be involved in behavioral outputof the circadian clock. C. Fu1, C. Whitfield1,2. 1) NeuroscienceDept., University of Illinois at Urbana Champaign; 2) EntomologyDept., UIUC, IL.

582CAdult circadian behavior requires developmental expression ofcycle, but not period. Tadahiro Goda, Stuart Currie, HermanWijnen. Biology, Univ Virginia, Charlottesville, VA.

583AS6kII (p90 ribosomal S6 kinase) Cooperates With Casein Kinase2 to Modulate the Drosophila Circadian Molecular Oscillator.Michelle M. Tangredi1, Bikem Akten1, Eike Jauch2, Fanny Ng1,Thomas Raabe2, F. Rob Jackson1. 1) Dept of Neuroscience,Tufts University School of Medicine, Boston, MA; 2) Universityof Wuerzburg, Wuerzberg, Germany.



584BEntrainment of molecular and behavioral circadian rhythms togradual environmental temperature cycles. Herman Wijnen,Stuart Currie. Dept Biol, Univ Virginia, Charlottesville, VA.

585Cjim lovell, a gene with structural and functional similarities tofruitless.. Sonia M. Bjorum, Kathleen M. Beckingham. Dept.of Biochemistry and Cell Biology, Rice University, Houston, TX.

586AChromatin regulators HP1 and Rpd3 function as opposingeffectors on neural masculinization in Drosophila. Hiroki Ito1,2,3,Masayuki Koganezawa1, Manabu Ote1,2, Ken Matsumoto2,Minoru Tateno2, Chihiro Hama3, Daisuke Yamamoto1,2. 1)Graduate School of Life Sciences, Tohoku University, Sendai,Miyagi, Japan; 2) Advanced Institute for Science andEngineering, Waseda University, Nishi-Tokyo, Tokyo, Japan; 3)Center for Developmental Biology, RIKEN, Kobe, Hyogo, Japan.

587BShaping of male courtship posture by lateralized gustatory inputsto sexually dimorphic fruitless-expressing neurons. MasayukiKoganezawa1, Daisuke Haba2, Takashi Matsuo2, DaisukeYamamoto1. 1) Div. Neurogenet., Tohoku Univ. Grad. Sch. LifeSci., Sendai 980-8578, Japan; 2) Dept. Biol.. Tokyo Metropol.Univ., Hachioji, Tokyo 192-0397, Japan.

588CA correlation between the location of axon termini of pheromonereceptor neurons and male-male courtship. Tetsuya Miyamoto,Hubert Amrein. Molecular Genetics and Microbiology, DukeUniversity Medical Center, Durham, NC.

589ASubsets of fruM neurons correlate with efficient courtship initiationand chemosenosory regulation. David H. Tran1, Bruce S.Baker1,2. 1) Department of Biology, Stanford Univ, Stanford, CA;2) HHMI Janelia Farm, Ashburn, VA.

590BDevelopmental switch in foraging versus burrowing behaviourin response to non-nutritive substrates in pre-critical weightversus post-critical weight Drosophila larvae. Beryl M. Jones1,2,Christen K. Mirth1, Rex Kerr1, Lynn M. Riddiford1. 1) JaneliaFarm, HHMI, 19700 Helix Drive, Ashburn, VA; 2) Department ofBiochemistry and Molecular Biophysics, University of Arizona,Tucson, AZ.

591CRegulation of the slo gene in the development of tolerance.Xiaolei Li, Harish Krishnan, Ben Troutwine, Nigel Atkinson.Sect Neurobiology, Univ Texas, Austin, Austin, TX.

592AAn Ecdysone Signal Lost: How is Ecdysone Signaling ThroughEcR Regulating Reproductive Behavior? Christoph C.Schwedes. Biology, Texas AUniv, College Station, TX.

593BA genome-wide screen for ion channels contributing to larvalmechanosensation. Jason C. Caldwell1, W. Daniel Tracey1,2,3.1) Dept Anesthesiology, Duke Univ Medical Ctr, Durham, NC;2) Dept Cell Biology, Duke Univ Medical Ctr, Durham, NC; 3)Dept Neuroscience, Duke Univ Medical Ctr, Durham, NC.

594CThe characterization of three novel ligand gated ion channelsubunits - Potential pesticide targets? Daniel Feingold, JosephDent. Biology, McGill University, Montreal, Quebec, Canada.

595AA genome-wide screen for ion channels involved in mechanicalnociception. Richard Hwang1, W. Daniel Tracey1,2,3. 1)Department of Neurobiology, Duke University, Durham, NC27710; 2) Department of Anesthesiology, Duke University,Durham, NC 27710; 3) Department of Cell Biology, DukeUniversity, Durham, NC 27710.

596BPhenotypes of Mutation in nervana 3, a β subunit of Na+/K+

ATPase, in Drosophila. Madhuparna Roy1, Ryan G. Kavlie2,Daniel F. Eberl1,2. 1) Department of Biology, Univ. of Iowa, IowaCity; 2) Genetics PhD Program, Univ. of Iowa, Iowa City.

597CRequirement of Dorsal Paired Medial Neurons for Consolidationof Long-term Aversive Olfactory Memory in Drosophila. JacobA. Berry, Ronald L. Davis. Baylor College of Medicine, OneBaylor Plaza, Houston, Tx. 77030.

598ARoles of the steroid molting hormone ecdysone in the formationof long-term courtship memory and modulation of sleep in adultDrosophila. Hiroshi Ishimoto1, Toshi Kitamoto1,2. 1) Departmentof Anesthesia, The University of Iowa, Iowa City, IA., U.S.A; 2)Interdisciplinary programs in Genetics and Neuroscience, TheUniversity of Iowa, Iowa City, IA., U.S.A.

599BSerotonin 5-HT1A-like, 5-HT2, and 5-HT7 Receptors ModulateLearning and Memory in Drosophila. O. Johnson, J. Becnel, C.D. Nichols. Dept Pharmacology, LSU Health Sciences Ctr, NewOrleans, LA.

600CExamination of memory processes requiring G(o) signaling inmushroom body. Adrian Madalan, Xiao Yang, Jacob Ferris,Gregg Roman. Department of Biochemistry Biology, Universityof Houston, Houston, TX.

601Agilgamesh, a casein kinase Iγ homologue, is required for short-term memory formation. Ying Tan, Dinghui Yu, Jennifer Reagan,Ronald Davis. Molecular and Cellular Biology, Baylor Collegeof Medicine, Houston, TX.

602BThe role of Activin signaling in adult Drosophila mushroom bodyneurons. Changqi Zhu1, Michael O'Connor2. 1) Department ofGenetics, Cell Biology and Development, University ofMinnesota, 6-160 Jackson Hall, Minneapolis, MN 55455; 2)Howard Hughes Medical Institutue, Department of Genetics, CellBiology and Development, University of Minnesota, 6-160Jackson Hall, Minneapolis, MN 55455.

603CFMRFamide (Fmrf)-dependent modulation of taste behavior.Yehuda Ben-Shahar. Biology, Washington University, St. Louis,MO.



604ABehavioral phenotypes associated with DH31 neurohormonesignaling in Drosophila. Colin A. Bretz, Erik C. Johnson.Biology, Wake Forest University, Winston-Salem, NC.

605BFunctional analysis of novel honey bee neuropeptide genes usingDrosophila melanogaster. Scott Kreher, Roveiza Irfan, NicoleSpencer, Gene Robinson. Univ Illinois, Urbana, IL.

606CStructure and functional analysis of Drosophila shor tNeuropeptide F. Kyu-Sun Lee, Ae-Kyeong Kim, Seung-HyunHong, Kweon Yu. Regenerative Med, KRIBB, Daejeon, Korea.

607AFmr1 expression both depends on and has an inverserelationship with sleep time in Drosophila. Daniel B. Bushey,Giulio Tononi, Chiara Cirelli. Dept. of Psychiatry, Univ. ofWisconsin, Madison.

608BGenetic dissection of complex behaviors in Drosophila mutantsof the Vesicular Monoamine Transporter (VMAT). AudreyChen1,2, Christine Djapri2,3, Wei-Song Ong3,4, GabrielSeidman2, David Krantz2,3,4. 1) Department of Neurobiology; 2)Hatos Center for Neuropharmacology; 3) Department ofPsychiatry and Biobehavioral Sciences; 4) InterdepartmentalProgram in Neuroscience; Gonda Center for Neuroscience andGenetics Research, David Geffen School of Medicine at UCLA,Los Angeles California, USA.

609CSpatio-temporal requirements of A-I RNA editing for correct adultbehavior in Drosophila. James E. C. Jepson, Robert A. Reenan.Department of Molecular Biology, Cell Biology and Biochemistry,Brown University, Providence, RI.

610AThe lithium-inducible solute carrier 6 transporter plays a criticalrole in resistance to lithium toxicity in Drosophila. Junko Kasuya1,Garrett Kaas2, Toshi Kitamoto1,2,3. 1) Anesthesia, University ofIowa, Iowa City, IA; 2) Interdisciplinary Graduate Program inGenetics, University of Iowa, Iowa City, IA; 3) InterdisciplinaryGraduate Program in Neuroscience, University of Iowa, IowaCity, IA.

611BIdentification of Command Neurons for Wing Expansion in theDrosophila Subesophageal Ganglion. Haojiang Luan, NathanPeabody, Fengqiu Diao, Benjamine White. Lab Molecular Biol,NIMH, Bethesda, MD.

612CAn automated array to study ethanol-induced behavioralphenotypes in Drosophila. Alleene Strickland, Erin Atkinson,Harish Krishnan, Nigel Atkinson. Section of Neurobiolgy, TheUniversity of Texas at Austin, Austin, TX 78712.

613ADevelopment of a behavioral assay for color vision. Nina Vogt,Claude Desplan. Dept Biol, New York Univ, New York, NY.

614BGenome-wide microarray analysis of increasing the appetiteupon starvation in Drosophila. Kazuyo Fujikawa1, AyaTakahashi1, Toshiyuki Takano-Shimizu1, Azusa Nishimura2,Yuko Ishida2, Masanobu Itoh3, Mamiko Ozaki2. 1) Departmentof Population Genetics, National Institute of Genetics, Mishima,Japan; 2) Department of Biology, Kobe University, Kobe, Japan;3) Department of Applied Biology, Kyoto Institute of Technology,Kyoto, Japan.

615CDeafness and Male Sterility in smetana Flies Result From aMutation in CG31623. Julie S. Jacobs1, Ryan G. Kavlie1,2,Daniel F. Eberl1,2. 1) Biology Department, University of Iowa,Iowa City, IA; 2) Interdepartmental Graduate Program inGenetics, University of Iowa, Iowa City, IA.

616ANeural circuits for CO2 repulsive behavior in the Drosophila Brain.H.-H. Lin, L.-A. Chu, T.-F. Fu, C.-Y. Lin, Z.-W. Huang, S.-F. Teng,A.-S. Chiang. Institute of Biotechnology National Tsing Hua Univ,Hsinchu, Taiwan.

617BFunctional and molecular analysis of tarsal gustatory sensilla.Frederick Ling1, Linnea A. Weiss1, Anupama Dahanukar2, JaeYoung Kwon3, John R. Carlson1. 1) Dept of Molecular, Cellularand Developmental Biology, Yale University, New Haven, CT06520; 2) Dept of Entomology, University of California, Riverside,Riverside, CT 92521; 3) Dept of Biological Science,Sungkyunkwan University, Gyounggi-do, South Korea 440-746.

618CThe suppressor of retinal degeneration, su(rdgB)82, maps tothe 53F8-54F1 region of chromosome 2. Don W. Paetkau,Kaitlyn S. Kuns, Calli A. Davison. Dept Biol, Saint Mary's Col,Notre Dame, IN.

619AInhibition of stress odor response: a novel paradigm for behaviormodification. Stephanie L. Turner1, Anandasankar Ray2. 1)Cellular, Molecular, and Developmental Biology Program.University of California, Riverside; 2) Department of Entomology.University of California, Riverside. 3401 Watkins Dr. Riverside,CA 92521.

620BAtypical soluble guanylyl cyclases mediate the larval hypoxiaescape response in Drosophila. Anke Vermehren, David B.Morton. Integrative Biosciences, OHSU, Portland, OR.

621CThe roles of Caki at Drosophila synapse. Kaiyun Chen, DaveFeatherstone. Department of Biological Sciences, Universityof Illinois at Chicago, Chicago, IL. 60607.

622Ajohn glenn (jog), a gene implicated in gravitaxis, may functiondownstream the Drosophila ortholog of the β-amyloid precursorprotein. Cassidy Brown Johnson1, Vanana Konduri1, SvenHueslsmann2, Nick Brown2, Kathleen M. Beckingham1. 1)Dept. of Biochemistry and Cell Biology, Rice University, Houston,TX; 2) Gurdon Institute and Dept. of Physiology, Developmentand Neuroscience, University of Cambridge, UK.



623BThe synaptic theory of ethanol tolerance- The mutants shibireand Syntaxin are required for functional tolerance to ethanol inDrosophila. Harish Krishnan, Yazan Al-Hasan, Nigel Atkinson.Section of Neurobiology, The University of Texas at Austin, Austin,TX 78712.

624CSialylation in protostomes: functional role of α2-6Sialyltransferase in Drosophila melanogaster. Elena Repnikova1,Kate Koles2, Vladislav Panin1. 1) Texas AUniversity, CollegeStation, TX; 2) 2University of Massachusetts Medical School,Worcester, MA.

Neurogenetics and Neural Development

625AAnalysis of the Drosophila crmp gene: Determining a role forthe CRMP protein in neuronal signaling and learning andmemory. Deanna Morris1, John Rawls1, Josh Dubnau2. 1)Department of Biology, University of Kentucky, Lexington, KY;2) Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.

626BG-protein coupled receptors in Drosophila nerve corddevelopment. Meghna V. Patel, Mark F. A. VanBerkum.Biological Sciences Department, Wayne State University, Detroit,MI.

627CRole of cell death gene reaper in restructuring the adultabdominal motor system. Soumya Banerjee1, Meredith Dorr2,Matt Seifert1, Kathleen Broomall1, Krista Hardin1, JoyceFernandes1. 1) Dept Zoology, Miami Univ, Oxford, OH; 2) TheUniversity of Toledo, Toledo, OH.

628AOverexpression of human UBQLN1 leads to premature deathand enhances overexpression of dPsn-induced retinaldegeneration in Drosophila. A. Li1, K. McKay1, J. Moore1, K.Raygor1, Y. Dong1,2, Z. Xie1,2, R. E. Tanzi1. 1) Genetics and AgingResearch Unit, Department of Neurology, MassGeneral Instituteof Neurodegenerative Diseases (MIND); 2) Department ofAnesthesia and Critical Care, Massachusetts General Hospitaland Harvard Medical School, Charlestown, MA.

629BDendritic territory specification by Dscam-mediated self-avoidance and Netrin-mediated dendritic guidance. BenjaminJ. Matthews1, Wesley B. Grueber1,2. 1) Department ofNeuroscience; 2) Department of Physiology, Columbia University.

630CMitochondrial protein Preli-like prevents from deficient growthand degradation of dendritic arbors of a subclass of Drosophilamultidendritic neurons. A. Tsubouchi1, T. Tsuyama1, M. Fujioka3,H. Kohda3, K. Okamoto-Furuta3, T. Aigaki2, T. Uemura1. 1)Graduate School of Biostudies, Kyoto University, Japan; 2)Department of Biological Science, Tokyo MetoropolitanUniversity, Japan; 3) Graduate School of Medicine, KyotoUniversity, Japan.

631ANanos regulation and function in the Drosophila PeripheralNervous System. Xin Xu1, Jillian Brechbiel2, Holly Cardoso1,Elizabeth Gavis1. 1) Molecular Biology, Princeton University,Princeton, NJ; 2) The Joseph Stokes Jr. Research Institute, TheChildren's Hospital of Philadelphia, Philadelphia, PA.

632BAtonal regulates EGF signaling and acts as cell fate switch. LisaM. Gutzwiller, Lorraine Witt, David Li-Kroeger, BrianGebelein. Developmental Biology, Cincinnati Children's Hospitaland Medical Center, Cincinnati, OH.

633CAtonal regulates EFG signaling and acts as a cell fate switch.Lisa M. Gutzwiller, Lorraine Witt, David Li-Kroeger, BrianGebelein. Developmental Biology, Cincinnati Children's Hospital,Cincinnati, OH.

634ARegulation of retinal differentiation by successive waves ofAtonal-related bHLH transcription factors. Shu Hu, XiaojiangQuan, Chingman Choi, Bassem Hassan. Department ofHuman Genetics/VIB11, Katholieke Universiteit Leuven, Leuven,Belgium.

635BThe regulation of signaling cascades by two cell adhesionmolecules: Echinoid and Friend of Echinoid, during theDrosophila retinal development. W. Julius Kim, Grant Simmons,Susan Spencer. Dept Biol, St Louis Univ, St Louis, MO.

636CA genetic screen for genes involved in neuronal specificationand connectivity in the Drosophila medulla. X. Li1, J. Morante1,A. Celik2, C. Desplan1. 1) New York University, New York, NY; 2)Bogazici University, Istanbul Turkey.

637ALethal Giant Larvae: a tumor suppressor that functions in neuraldevelopment. Aimee J. Littleton1, Alona S. Sukhina1, PatriciaS. Estes1, Daniela C. Zarnescu1,2,3. 1) Molecular and CellularBiology, University of Arizona, Tucson, AZ; 2) Division ofNeurobiology, University of Arizona, Tucson, AZ; 3) GraduateInterdisciplinary Program in Genetics, University of Arizona,Tucson, AZ.

638BCharacterization of aaquetzalli (aqz), a gene required fordevelopment of the nervous system during Drosophilamelanogaster embryogenesis. Miguel A. Mendoza-Ortiz. DeptDev Biol, Inst Neurobiologia, UNAM, Queretaro, Queretaro,Mexico.

639CDystroglycan affects the boundary between the lamina and thelobula in the optic lobe of the third instar larval brain. MarioPantoja1, James Reinecke2, Katherine Park1, Ellen Ward1,Hannele Ruohola-Baker1. 1) Dept Biochemistry, UnivWashington, Seattle, WA; 2) Central Michigan University, MountPleasant, MI.



640AThe unfulfilled/DHR51 gene is required for the development ofmushroom body neuropil. K. E. Bates, C. Sung, S. Robinow.Zoology, University of Hawaii, Honolulu, HI.

641BRal GTPase is a negative regulator of Epsin-mediated N/Dlsignaling in Drosophila. B. Cho, J. Fischer. MCDB, TheUniversity of Texas at Austin, TX.

642COver-Expression of the Notch Intracellular Domain in Glial CellsPotentiates Long-Term Survival of Drosophila in Hypoxia.DeeAnn W. Visk, Dan Zhou, and Gabriel G. Haddad. DeeAnnW. Visk1, Dan Zhou2, Gabriel G. Haddad2,3. 1) Division ofBiology, University of California, San Diego, La Jolla, CA; 2)Department of Pediatrics, School of Medicine, Univeristy ofCalifornia, San Diego, La Jolla, CA; 3) Rady Children's Hospital,San Diego, CA.

643ADrosophila myb is required for appropriate neuronal apoptosisat the wing margin. M. Rovani, G. Ramsay, A. Katzen. Dept ofBiochemistry Molecular Genetics, Univ Illinois at Chicago,Chicago, IL.

644BInvestigation of a potential target gene of the proneuraltranscription factor, Atonal. Lina Ma, Sebastián Cachero, Petrazur Lage, Andrew Jarman. Centre for Integrative Physiology,University of Edinburgh, United Kingdom.

645CThe role of Cut in Johnston's organ development and function.Elena Sivan-Loukianova1, Julie S. Jacobs1, Grace Boekhoff-Falk2, Daniel F. Eberl1. 1) Dept. of Biological Sciences, Universityof Iowa, Iowa City; 2) Dept. of Anatomy, University of Wisconsin,Madison.

646AFragile X protein controls the proliferation and differentiation ofneural stem cells. Matthew A. Callan1, Jennifer C. Heck1,Daniela C. Zarnescu1,2,3. 1) Department of Molecular CellularBiology, University of Arizona, Tucson, AZ; 2) Division ofNeurobiology and; 3) Graduate Interdisciplinary Program inGenetics.

647BPhosphorylation of numb by a novel kinase regulates neuralstem cell self-renewal in Drosophila. Yingshi Ouyang, BingweiLu. Department of Pathology, Stanford University School ofMedicine; GRECC/VAPAHCS, Palo Alto, CA 94304, USA.

648CThe endocytic pathway regulates neural stem cell self-renewal.Yan Song1,2, Bingwei Lu1,2. 1) Dept Pathology, Stanford Univ,Palo Alto, CA; 2) GRECC/VAPAHCS, Palo Alto, CA 94304, USA.

649AAutophagy Promotes Synaptic Growth by Down-RegulatingHighwire. Wei Shen, Barry Ganetzky. Laboratory of Genetics,University of Wisconsin, 425-G Henry Mall, Madison, WI 53706.

650BDownstream targets of BMP/Wit signaling in Drosophilamotorneurons. Arpan Ghosh. Genetics Cell and Development,University of Minnesota Twin Cities, Minneapolis, MN.

Pattern Formation

651CEnzyme-substrate competition network integrates patterningsignals in the Drosophila embryo. Yoosik Kim1, MathieuCoppey1, Leiore Ajuria2, Gerardo Jiménez2, Ze'ev Paroush3,Stanislav Y. Shvartsman1. 1) Department of ChemicalEngineering and Lewis-Sigler Institute for Integrative Genomics,Princeton University, USA; 2) Institut de Biologia Molecular deBarcelona-CSIC, Parc Científic de Barcelona, Barcelona, Spain;3) Department of Biochemistry, Faculty of Medicine, The HebrewUniversity, PO Box 12272, Jerusalem 91120, Israel.

652AAnterior-posterior regulation of mirror expression in the absenceof its negative regulator capicua during Drosophila oogenesis.Jean-Francois B. Lachance, Laura Nilson. Dept Biol, McGillUniv, Montreal, PQ, Canada.

653Bdoctor no and ken and barbie are involved in the left-rightasymmetric development of the Drosophila embryonic gut. ReoMaeda1, Kiichiro Taniguchi1, Kenji Matsuno1,2. 1) Dept. Biol.Sci./Tech., Tokyo Univ. of Sci; 2) Res. Ins. Sci./Tec., Tokyo Univ.of Sci.

654CA genetic screen to identify genes involved in the left-rightasymmetric development of the embryonic gut in Drosophila.Naotaka Nakazawa1, Mitsutoshi Nakamura1, KiichiroTaniguchi1, Takashi Okumura1, Reo Maeda1, HarukaYamamoto1, Ryo Hatori1, Akira Ishio1, Ayumi Ozaki1, KenjiMatsuno1,2. 1) Dept. Biol. Sci / Tec., Tokyo Univ. Sci., noda, chiba,Japan; 2) Res. Ins. Sci / Tec., Tokyo Univ. Sci.

655AA nonmuscle Myosin II heavy chain, Zipper is required for theleft-right asymmetric morphogenesis of the anterior midgut inDrosophila embryo. Takashi Okumura1, Hiroo Fujiwara1,Kiichiro Taniguchi1, Reo Maeda1, Shunya Hozumi1, NaotakaNakazawa1, Kenji Matsuno1,2. 1) Dept. Biol. Sci/Tec, Tokyo Univ.Sci; 2) Res. Ins. Sci/Tec, Tokyo Univ. Sci.

656BCharacterization and functional analysis of the Drosophila CorinProtein. Atsushi Sato1,2, Hiroshi Shibuya1, AndrewTomlinson2. 1) Department of Molecular Cell Biology, MedicalResearch Institute, Tokyo Medical and Dental University, Tokyo,Japan; 2) Department of Genetics and Development, College ofPhysicians and Surgeons, Columbia University, New York, NY.



657CAntagonistic interaction of L and hth to define ventral eyeboundary is independent of the exd function. Meghana Tare1,Madhuri Kango-Singh2, Kyung-Ok Cho3, Kwang-WookChoi3,4, Amit Singh1,5. 1) Department of Biology, University ofDayton, OH; 2) Mercer University School of Medicine, Divisionof Basic Sciences, Macon, GA; 3) Dept of Biological SciencesKorea Advanced Institute of Science and Technology, Daejeon,Korea; 4) Baylor College of Medicine, Houston, Texas; 5) Centerfor Tissue Regeneration and Engineering at Dayton (TREND),University of Dayton, OH.

658AOrganism-scale modeling of early Drosophila patterning viaBone Morphogenetic Proteins. David M. Umulis1, OsamuShimmi2, Hans Othmer3, Michael O'Connor4. 1) Ag. andBiological Engineering, Purdue University, West Lafayette, IN;2) Institute of Biotechnology, University of Helsinki, 00014Helsinki, Finland; 3) Howard Hughes Medical InstituteInvestigator, and Department of Genetics, Cell Biology, andDevelopment, Minneapolis, MN 55455, USA; 4) School ofMathematics and Digital Technology Center, Minneapolis, MN55455, USA.

659BMechanics of apical constriction in amnioserosa cells duringdorsal closure. M. Shane Hutson1,2, Xiaoyan Ma1, Holley E.Lynch1, Peter C. Scully1. 1) Physics Astronomy, VanderbiltUniversity, Nashville, TN; 2) Biological Sciences, VanderbiltUniversity, Nashville, TN.

660CIdentification of genes required for epithelial closure processesin Drosophila embryos. Ferenc Jankovics, Agnes Varga, MargitSzathmari, Ildiko Krausz, Laszlo Henn, Miklos Erdelyi.Biological Research Center , Institute of Genetics, Szeged,Hungary.

661AGrowth of compartments in eye-antenna discs are differentiallyregulated by Hedgehog (Hh), Decapentaplegic (Dpp), andWingless (Wg). W. Son1, A. Singh2, K.-W. Choi3, K.-O. Cho3. 1)Dept of Molecular and Cellular Biology, Baylor College ofMedicine, Houston, TX; 2) Dept of Biology, University of Dayton,Dayton, OH; 3) Dept of Biological Sciences, KAIST, Daejeon,Korea.

662BDeconstructing the redundancy between Dpp and Hh signalingin Drosophila eye development. Fernando Casares, CarlaLopes. CABD (Centro Andaluz de Biologia del Desarrollo),CSIC-Univ Pablo Olavide, Sevilla, Spain.

663CA Broad Gene Network Directly Regulated by eyeless DuringRetinal Development in Drosophila. R. Chen1,2,3, Y. Chen1,2, X.Song1,2, Y. Li1,2. 1) HGSC; 2) Mol. Human Genetics; 3) Program inDevelopmental Biology, Baylor College of Medicine, Houston, TX.

664Aoptix modulates dpp/hh pathway controlling morphogeneicfurrow progression during retinal development. R. Chen1,2,3, Y.Jiang2, U. Karandikar4, K. Hoffman4, G. Mardon2,3,4,5, Y. Li1,2. 1)HGSC; 2) Mol. Human Genetics; 3) Program in Dev. Biology; 4)Pathology; 5) Neuroscience, Baylor Col Med, Houston, TX.

665BEy, Dac, Dan, Danr and CtBP form a complex or complexes tospecify eye precursors. Chinh Q. Hoang, Micheal Burnett,Andrea Sandoval, Jennifer Curtiss. Molecular Biology, NewMexico State University, Las Cruces, NM.

666CDorsal eye selector, pannier (pnr), interacts with the retinaldetermination gene network during Drosophila eye development.S. M. Oros1,2, A. Singh2,3. 1) Premedical Programs, Universityof Dayton, Dayton, OH 45469-2320; 2) Department of Biology,University of Dayton, Dayton, OH 45469-2320; 3) Center forTissue Regeneration and Engineering at Dayton (TREND),University of Dayton, Dayton, OH 45469-2320.

667ARegulation of planar cell polarity by the atypical cadherins Fatand Dachsous. Praveer Sharma1,2, Helen McNeill1,2. 1)University of Toronto, Ontario, Canada; 2) Samuel LunenfeldResearch Institute, Toronto, Ontario, Canada.

668BControl of planar cell polarity in the Drosophila eye as directedby the giant cadherin Fat and its binding partners. A. Sing, H.McNeill. Molecular Genetics, University of Toronto, Toronto,Ontario, Canada.

669CRole of Lobe in TOR signaling in Drosophila eye development.Wonseok Son, Ya-Chieh Hsu, Kwang-Wook Choi. Dept CellBiol, Baylor College of Medicine, Houston, TX., Select a Country.

670AMultiple Roles for Notch in R7 Specification. Andrew Tomlinson.Dept Genetics Development, Columbia Univ, New York, NY.

671BSimilar function despite being different: regulation of abdominalcharacters by Bithorax complex genes. N. Sambrani, S. Merabet,J. Pradel, Y. Graba. IBDML, Marseille, France.

672CRegulation of the Sex combs reduced gene within the transverserow bristle primordia of legs in the first thoracic segment. EmilyJensen, Stuti Shroff, Teresa Orenic. Dept Biological Sci, UnivIllinios, Chicago, Chicago, IL.

673ASpecification of antennal identity in larval and adult Triboliumcastaneum. Teresa D. Shippy, Stephanie J. Yeager, Robin E.Denell. Div Biol, Kansas State Univ, Manhattan, KS.

674BStudy of tracheal extension during Drosophila eye development.W. C. Chu1,2, Y. M. Lee1,3, W. Y. Tsai1,2, Y. H. Sun1,2,3. 1) Institudeof Molecular Biology, Academia SINICA, Taipei, Taiwan; 2)Graduate Institute of Life Sciences, National Defense MedicalCenter, Taipei, Taiwan; 3) Department of Life Sciences andInstitute of Genome Sciences, National Yang Ming University,Taipei, Taiwan.

675CZelda regulates expression of early zygotic microRNAs. ShengboFu, Chung-Yi Nien, Hsiao-Lan Liang, Prabhjot Singh, ChristineRushlow. Biology, New York Univ, New York, NY.



676ASpatial regulation of achaete via global activation and repressionby Hairy and Delta. Ji Inn Lee, Meghana Joshi, Teresa Orenic.Dept Biological Sci, Univ Illinois, Chicago, Chicago, IL.

677BAn unconventional eIF4G homolog dNAT1 regulates E74Aprotein translation during Drosophila metamorphosis. MakotoNakamura. College of Pharmaceutical Sciences, MatsuyamaUniversity, Matsuyama, Japan.

678CThe Zinc-finger protein Zelda is a key activator of the early zygoticgenome in Drosophila. C. Nien, H. Liang, H. Liu, M. Metzstein,N. Kirov, C. Rushlow. Dept Biol, New York Univ, New York, NY.

679AComputational and genetic analysis of negative feedback controlin eggshell patterning. Jeremiah Zartman, Shoshana Leffler,Colin Watson, Elizabeth Oeffinger, Stanislav Shvartsman.Lewis Sigler Institute and Department of Chemical Engineering,Princeton University, Princeton, NJ.

680Bhunchback promoter structure and the control of spatial noiseduring expression. David M. Holloway1, Francisco J. P.Lopes2,3, Alexander V. Spirov3. 1) Math, British Col Inst Tech,Burnaby; Biology, U. of Victoria, BC, Canada; 2) Biophysics, Univ.Federal Rio de Janeiro, Brazil; 3) Appl. Math, and Dev. Genetics,Stony Brook Univ., NY.

681CExtracellular regulation of Hedgehog signaling by secretedprotein Shifted and its vertebrate ortholog the Wnt InhibitoryProtein-1. Andrei Avanesov, Shawn Honeyager, Seth Blair.Zoology, University of Wisconsin, Madison, WI.

682AThe Fat/Dachsous pathway orients an Early Phase of FrizzledPCP signaling in the wing. Simon Collier, Justin Hogan, KristyDoyle, Chris Cox. Dept Biological Sci, Marshall Univ, Huntington,WV.

683BThe role of bowl in specifying the migratory behavior of epithelialedge cells that mediate dorsal closure of Drosophila mesothorax.Steven J. Del Signore, Victor Hatini. Department of Anatomy,Tufts University School of Medicine, Boston, MA.

684CThe DHHC palmitoyltransferase Approximated regulates Fatsignaling and Dachs localization and activity. Hitoshi Matakatsu,Seth Blair. Dept Zoology, Univ Wisconsin, Madison, WI.

685AThe bHLH protein Delilah affects intervein cell differentiation byregulating the expression of cell-adhesion molecules. AdiSalzberg, Nirit Egoz, Atalya Nachman, Yifat Klein. DeptGenetics, Rappaport Fac Medicine, Technion Israel Institute ofTechnology, Haifa, Israel.

Physiology and Aging

686BMating modifies longevity extension by diet restriction andmediates a mito-nuclear epistasis for life history traits. David M.Rand, M. Rubinstein, K. L. Montooth, C. D. Meiklejohn, D.Abt. Ecology Evolutionary Biol, Brown Univ, Providence, RI.

687CHigh calorie diet-induced reduction of sleep and lifespan indopamine transporter mutant, fumin. K. Takahama, M. Yamazaki,E. Sakamoto, M. Mitsuyoshi, T. Ueno, J. Tomita, S. Kume, K.Kume. Stem Cell Biology, Graduate School of Medical Sciencesand Institute of Molecular Embryology and Genetics, KumamotoUniversity, Kumamoto 860-0811, Japan.

688AThe Effect of feeding regimens on food consumption inDrosophila. Einat Zelinger1, Oren Froy2, Yael Heifetz1. 1) Dept.ofEntomology, Hebrew University, Rehovot, Israel; 2) Institute ofBiochemistry, Food Science and Nutrition, Hebrew University,Rehovot, Israel.

689BGenetic dissection of puparium formation. A. Engstrom, D.Braun, A. Bashirullah. University of Wisconsin, Madison, WI.

690CThe role of Drosophila insulin-like-peptides in development,metabolism and aging. Sebastian Grönke, David Clarke, LindaPartridge. Institute of Healthy Ageing, University CollegeLondon, London, United Kingdom.

691ACharacterization of a co-factor involved in ecdysone biosynthesis.Rachel J. Herder, Michael B. O'Connor. Genetics CellDevelopment, University of Minnesota, Minneapolis, MN.

692BRole of Drosophila CycD/Cdk4 as a metabolic regulator. MojcaAdlesic, Christian Frei. Institute of Cell Biology, ETH Zurich,Switzerland.

693CNovel mechanisms of lifespan modulation through ponchik.Tammy P. Chan1,2, Sergiy Libert1,3, Emmeline Peng1, JessicaE. Zwiener1, Danielle A. Skorupa1,3, Scott D. Pletcher1,2,3,4. 1)Huffington Ctr Aging, Baylor Col Medicine, Houston, TX; 2)Program in Developmental Biology, Baylor Col Medicine,Houston, TX; 3) Program in Cell and Molecular Biology, BaylorCol Medicine, Houston, TX; 4) Department of Molecular andHuman Genetics, Baylor Col Medicine, Houston, TX.

694AMeasuring mitochondrial DNA mutation rate and bias. StevenA. DeLuca, Hong Xu, Patrick O'Farrell. University of CaliforniaSan Francisco, San Francisco, CA.

695BThe regulation of metabolic activity by the circadian clock inDrosophila melanogaster. Justin R. DiAngelo, Kanyan Xu,Amita Sehgal. Department of Neuroscience, University ofPennsylvania and Howard Hughes Medical Institute,Philadelphia, PA.



696CThe role of AMP-activated protein kinase signaling in theDrosophila ovary. C. E. Hector, C. A. Bretz, E. C. Johnson.Department of Biology, Wake Forest University, Winston-Salem,NC.

697ASir2 regulates organismal energy homeostasis in Drosophilamelanogaster. T. Reis, I. Hariharan. Dept MCB, Univ California,Berkeley, Berkeley, CA.

698BRoles for the DHR38 nuclear receptor in carbohydratemetabolism. Anne-Francoise Ruaud, Carl Thummel.Department of Human Genetics, University of Utah School ofMedicine, Salt Lake City, UT.

699CThe Drosophila Estrogen-Related Receptor is an EssentialRegulator of Carbohydrate Metabolism. Jason M. Tennessen,Keith D. Baker, Geanette Lam, Janelle Evans, Carl S.Thummel. Institute of Human Genetics, University of Utah, SaltLake City, UT.

700ASpargel, a putative Drosophila homologue of the mammalianPGC-1 family, is involved in the metabolic control of larval growth.S. Tiefenbock, C. Frei. Cell Biology, ETH Zurich, Switzerland.

701BCarbon dioxide sensing modulates the lifespan and dietperception in Drosophila. Peter C. Poon, Scott D. Pletcher.Huffington Ctr Aging, Baylor Col Med, Houston, TX.

702CDelg controls mitochondrial biogenesis in the Drosophila adiposetissue in response to nutrients and Cyclin D/Cdk4. C. Baltzer1,3,M. Marti2, C. Frei1. 1) Institute of Cell Biology, ETH Zurich,Switzerland; 2) Kantonsschule Willisau, [email protected]; 3) PhD program in Molecular LifeSciences, Zurich, Switzerland.

703AImpact of taurine on lifespan and development of Drosophila.Stephanie Shirkey1, Ishtiaq Habib1, Alexander Milne1, JeremyNadolski2, Lee Ann Smith3. 1) Undergraduate student in Biology,Benedictine University, Lisle, IL; 2) Department of Mathemcaticsand Computer Science, Benedictine University, Lisle, IL; 3)Department of Biology, Benedictine University, Lisle, IL.

704BThe relationship between pheromones and aging in Drosophilamelanogaster. Tsung-Han Kuo1, Joanne Yew2, ScottPletcher1,3. 1) Molecular Human Genetics, Baylor College ofMedicine, Houston, TX; 2) Department of Neurobiology, HarvardMedical School, Boston, MA; 3) Molec Human Gen, BaylorCollege of Medicine, Houston, TX.

705CContribution of microRNA34 to the biology of aging in Drosophila.Sanjay Nag, Atanu Duttaroy. Dept Biol, Howard Univ,Washington, DC.

706AA cytochrome P450 potentially involved in the juvenile hormonepathway in Drosophila. Tamar E. Sztal, Henry Chung, PhilipBatterham, Phillip. J. Daborn. Department of Genetics, Bio21Institute, University of Melbourne, Melbourne.

707BManipulating the Metazoan Mitochondrial Genome with TargetedRestriction Enzymes. Hong Xu, Steven Deluca, PatrickO'Farrell. Dept Biochem Biophysics, Univ California, SanFrancisco, San Francisco, CA.

708CPro-inflammatory Processes in Aging and Metabolism. TianshuYang, Scott Pletcher. TBMM program, Baylor College ofMedicine, Houston, TX.

709ADiet and age play an important role in paraquat resistance inDrosophila melanogaster. N. S. Abel1, W. J. Wolfgang2,3, J. A.McLear4. 1) Molecular Biology and Genetics, Cornell University,Ithaca, NY 14853; 2) Wadsworth Center, New York StateDepartment of Health, Albany, NY 12208; 3) Department ofBiomedical Sciences, University at Albany, Albany, NY 12203;4) Biology Department, Utica College, Utica, NY 13502.

710BConserved Role of Mitochondrial Aldehyde Dehydrogenase:Protection from Oxidative Stress? Mahul Chakraborty, JamesFry. Department of Biology, University of Rochester, Rochester,NY.

711CRole of cellular damage in aging of male germline and somaticstem cells. Matthew R. Wallenfang, Noor Al-Husayni,Khadeejah Bari, Christine Chang, Debbie Chen, DenisseIzquierdo, Saira Siddiqui. Dept Biological Sci, Barnard College,New York, NY.

712AMultiple measures of functionality exhibit progressive decline ina parallel, stochastic fashion in Drosophila Sod2 null mutants.Robert J. Wessells1, Nicole Piazza1, Michael Hayes1, IanMartin2, Atanu Duttaroy3, Mike Grotewiel2. 1) Dept Intnl Med/Geriatrics, Univ Michigan, Ann Arbor, MI; 2) Department ofHuman and Molecular Genetics and Neuroscience Program,Virginia Commonwealth University, Richmond, VA; 3) BiologyDepartment, Howard University, NW, Washington, DC.

713BHyperproduction of Drosophila CG9809, a mammalian homologof PGC-1 gene, is effective in lifespan extension. Atanu Duttaroy,Claudette Davis, Sanjay Nag, Renee Forde. Dept Biol, HowardUniv, Washington, DC.20059.

714CDrosophila as a model system to analyse TRP channels functionin cardiovascular physiology. Laurent Perrin1, SebastienSenatore1, Reddy Vatrapu1, Bruno Monier1,2, MichelSemeriva1, Nathalie Lalevee1. 1) IBDM, CNRS, Marseille,France; 2) Physiology, Development Neuroscience Universityof Cambridge, UK.



715ATranscriptional regulation of a protective factor NMNAT uponstress. Yousuf Ali1, Ryan McCormack2, Grace Zhai1. 1)Molecular and Cellular Pharmacology, Miller School of Medicine,University of Miami, FL; 2) Department of Biology, University ofMiami, Coral Gables, FL.

716BThe energetic cost of increased thermotolerance in Drosophilamelanogaster. Luke A. Hoekstra1, Kristi Montooth1, GeorgeW. Gilchrist2. 1) Department of Biology, Indiana University,Bloomington, IN; 2) Department of Biology, College of Williamand Mary, Williamsburg, VA.

717CRegulation of Glutathione S-transferase S1 (GSTS1-1)expression by the Keap1/Nrf2 signaling pathway. Mai K. Vuong1,Gwendolyn S. Carter1, Sarah Dauback2, Gerasimos P.Sykiotis3, Helen Benes1. 1) Neurobiology DevelopmentalSciences, University of Arkansas for Medical Sciences, LittleRock, AR; 2) Pharmacology Toxicology, University of Arkansasfor Medical Sciences, Little Rock AR; 3) Biomedical Genetics,University of Rochester Medical Center, Rochester, NY.

718AGenetic and drug screen on longevity mediated by ASIC2a inDrosophila melanogaster.. Y. Yuan, L. Liu. Peking University,Beijing, China.

Regulation of Gene Expression

719BThe role of tyrosine in gene regulation by the Drosophilasegmentation protein Fushi tarazu. Dan Bath, AnthonyPercival-Smith. Dept. of Biology, University of Western Ontario,London, Ontario, Canada.

720CRole of MEF2 in adult muscle development by comparativeexpression analysis. Anton L. Bryantsev, Richard M. Cripps.Department of Biology, University of New Mexico, Albuquerque,NM.

721ACF2 transcription factor plays a key role during Drosophilamyogenesis. Margarita Cervera1, Juan J. Arredondo1, SanfordI. Bernstein2, Jorge Vivar1. 1) Dept Bioquimica, CSIC/UAM,Madrid, Spain; 2) Department of Biology, SDSU, San Diego,California, USA.

722BCharacterization of Drosophila Cara mitad, a conserved nuclearreceptor coactivator essential for hormone dependentdevelopment. Chhavi Chauhan, Claudia Zraly, VenkatBoddapati, Manuel Diaz, Andrew Dingwall. CBCC, LUC,SSOM, Maywood, IL 60153.

723CEvolutionary Changes in Transcription Activation by Hox Proteins.Annie Huang1, Zabeena Merchant2, Ying Liu2, KathleenMatthews2, Sarah Bondos1,2. 1) Department of MolecularCellular Medicine, Texas AHealth Science Center, CollegeStation, TX; 2) Department of Biochemistry and Cell Biology,Rice University, Houston, TX.

724AMitochondrial biogenesis is regulated by dPGC-1, a crucialcoactivator homolog of PGC-1α in mammals. Maria Cruz Marín,Juan J. Arredondo, Rafael Garesse, Margarita Cervera. DeptBioquimica, Facultad de Medicina, UAM, Madrid, Spain.

725BRole of DREF in transcriptional regulation of the Drosophila p53gene. N. Trong Tue, D. Phuong Thao, M. Yamaguchi. Appliedbiology, Kyoto Institute of Technology, Kyoto, Kyoto, Japan.

726CTissue-specific composition and targeting of the DrosophilaSAGA complex. Vikki M. Weake1, Sebastián Guelman1,2, SeleneSwanson1, Christopher Seidel1, Michael Washburn1, SusanM. Abmayr1, Jerry L. Workman1. 1) Stowers Institute for MedicalResearch, Kansas City, MO; 2) Genentech, Inc., 1 DNA Way,South San Francisco, CA.

727AComputational identification of cis-regulatory elementscontrolling gene expression patterns in Drosophilaembryogenesis. Manonmani Arunachalam1, Pavel Tomancak1,Uwe Ohler2. 1) Max Planck Institute for Cell Biology andGenetics, Dresden, Germany; 2) Institute for Genome sciencesand Policy Duke university NC.

728BPaused/stalled Hox gene promoters contain insulator activityand help maintain higher order chromatin structures. Vivek S.Chopra, Michael Levine. Dept Mol Cell Biol, UC Berkeley,Berkeley, CA.

729CExploring The Late Abdominal B Expression Pattern Using BACs.Dragan Gligorov, François Karch, Robert Maeda. Zoology andAnimal Biology , University of Geneva, Geneva, Switzerland.

730Atfiia-s-2 (CG11693) encodes a germline-specific homolog of theGeneral Transcription factor TFIIA gamma subunit. Mark A. Hiller,Haley Adams, Margaret Wood, Cynthia Maddox. Biology,Goucher College, Baltimore, MD.

731BSolexa meets allele-specific gene expression in Drosophila.Bradley J. Main1, Ryan D. Bickel1, Rita Graze2, PeterCalabrese1, Sergey Nuzhdin1. 1) MCB, University of SouthernCalifornia, Los Angeles; 2) Department of Molecular Geneticsand Microbiology, University of Florida.

732CIdentification of the Drosophila Mes4 gene as a novel target ofthe transcription factor DREF. Osamu Suyari, Hiroyuki Ida,Yasuhide Yoshioka, Yasuko Kato, Reina Hashimoto,Masamitsu Yamaguchi. Department of Applied Biology, InsectBiomedical Research Center, Kyoto Institute of TechnologyMatsugasaki, Sakyo-ku, Kyoto 606-8585 Japan.



733ADiscovery of new sequence motifs in single and alternativepromoters. Qianqian Zhu1,2, Denison J. Kuruvilla3, Marc S.Halfon1,4,5,6. 1) Dept. of Biochemistry; 2) Biostatistics; 3)Biotechnology; 4) Biology, State University of New York at Buffalo,Buffalo NY 14214; 5) NY State Center of Excellence inBioinformatics and Life Sciences, Buffalo, NY 14203; 6)Molecular and Cellular Biology Dept., Roswell Park CancerInstitute, Buffalo NY 14263.

734BInvestigating the recruitment and roles of Topoisomerase I atactivated genes. Katie L. Zobeck1, Warren R. Zipfel2, Watt W.Webb3, John T. Lis1. 1) Molecular Biology Genetics; 2)Biomedical Engineering; 3) Applied Engineering Physics, CornellUniversity, Ithaca, NY.

735CTranscriptional regulation of the Drosophila melanogasterCyp12d1 gene. Adrian Boey, Phillip Daborn, PhilipBatterham. Centre for Environmental Stress and AdaptationResearch (CESAR), Department of Genetics, University ofMelbourne, Melbourne, Australia.

736ASequence specificity of Drosophila neuroblast enhancersrevealed by EvoPrinter and cis-Decoder analysis. ThomasBrody, Mukta Kundu, Alexander Kuzin, Jermaine Ross, WardOdenwald. Neural Cell-Fate Determinants, NINDS/NIH,Bethesda, MD.

737BIdentification of elements necessary for long-range enhanceractivity. Nicole C. Evans, Christina I. Swanson, Scott Barolo.Cell and Developmental Biology, Univiersty of Michigan, AnnArbor, MI.

738CIdentification of cis-regulatory elements using computational andexperimental approaches. W. Fisher, R. Weiszmann, A.Hammonds, S. MacArthur, X. Li, A. DePace, S. V. E. Keränen,C. Henriquez, C. Luengo, C. Fowlkes, D. Knowles, J. Malik,B. Berman, M. Eisen, M. D. Biggin, S. E. Celniker. BerkeleyDrosophila Transcription Network Project, Lawrence BerkeleyNational Laboratory, Berkeley, CA.

739ARegulation of repo transcription in Drosophila. Robert W.Johnson, Jamie L. Wood, William C. Colley, Bradley W. Jones.Dept of Biology, The University of Mississippi, Oxford, MS.

740BEvolution of enhancer position in the Drosophila yellow gene.Gizem Kalay1, Patricia Wittkopp1,2. 1) Molecular, Cellular andDevelopmental Biology Department, University of Michigan, AnnArbor, MI; 2) Ecology and Evolutionary Biology Department,University of Michigan, Ann Arbor, MI.

741CP-element homing, promoter specificity, and long distance actionof engrailed regulatory DNA. Judith A. Kassis, Deborah Kwon,Yuzhong Cheng, Sarah DeVido, Jeffrey Americo. LMG/NICHD/NIH, Bethesda, MD.

742AMotif discovery and target identification in Drosophila usinggenome-wide experimental data. Pouya Kheradpour1,Christopher Bristow1, Alexander Stark2, Manolis Kellis1. 1)CSAIL, MIT, Cambridge, MA; 2) IMP, Vienna, Austria.

743BSystems biology analysis of cis-regulatory control of theexpression of Drosophila even-skipped stripes 2 and 3. Ah-RamKim1, John Ionides2, David Sharp3, John Reinitz1. 1)Department of Applied Mathematics and Statistics,and Centerfor Developmental Genetics, Stony Brook University, StonyBrook, NY; 2) Department of Computational Biology, Center ofAdvanced Studies, St.Petersburg State Polytechnic University,St.Petersburg, 195251, Russia; 3) Chief Science Office, LosAlamos National Laboratory, Los Alamos, NM.

744CFunctional Analysis of the castor Neuroblast Enhancer. MuktaRani Kundu, Alexander Kuzin, Jermaine Ross, ThomasBrody, Ward Odenwald. Neural Cell Fate Determinants, NINDS,Bethesda, MD.

745AHim is a transcriptional target of Twist as an inhibitor of myoblastdifferentiation in Drosophila. Thai Lee1, Jennifer Elwell2, RichardCripps1. 1) Biology, University of New Mexico, Albuquerque, NM;2) New Mexico Department of Health, Albuquerque, NM.

746BComparative genome-wide analysis of transcription factorbinding in the embryos of different Drosophila species. Xiao-Yong Li1,2, R. Bradley2,3, S. Davidson1, H. C. Chu1, M. D. Biggin1,M. B. Eisen1,2,3. 1) Berkeley Drososphila Network Project,Lawrence Berkeley National Laboratory, Berkeley, CA; 2) HowardHughes Medical Institute, University of California, Berkeley; 3)Dept. of Molecular and Cell Biology, University of California,Berkeley.

747CTranscription Factors of the Early Development RegulatoryNetwork Bind Broadly Over a Quantitative Continuum to HighlyOverlapping Genomic Regions in Drosophila Embryos. Xiao-Yong Li1,2, S. MacArthur1, P. Sabo3, S. Thomas3, H. C. Chu1, L.Zhen1, A. Hechmer1, L. Simirenko1, M. Stapleton1, J.Stamatoyannopoulos3, M. D. Biggin1, M. B. Eisen1,2,4. 1)Berkeley Drosophila Transcription Network Project, LawrenceBerkeley National Laboratory, Berkeley, CA; 2) HMMI, Universityof California, Berkeley; 3) Dept. of Genome Sciences, Universityof Washington; 4) Dept. of Molecular and Cell Biology, Universityof California, Berkeley.

748ATranscriptional control of xenobiotic detoxification in Drosophila.Jyoti R. Misra, Mike A. Horner, Carl S. Thummel. Dept. ofHuman Genetics, University of Utah, Salt Lake City.

749BRegulation of early Mef2 expression in the developing mesoderm.Ginny Morriss, Richard Cripps. Department of Biology,University of New Mexico, Albuquerque, NM.



750CMechanisms of tissue-specific responses to Hedgehog signaling.David S. Parker, Scott Barolo. Dept. CDB, University ofMichigan, Ann Arbor.

751ADeciphering shavenbaby regulatory code in epidermal cells.Serge Plaza1, Stein Aerts2, Isabelle Fernandes1, YvanLatapie1, Pierre Ferrer1, Jennifer Zanet1, Francois Payre1. 1)Centre de biologie du developpement, CNRS UMR5547,Universite Paul Sabatier, toulouse , France; 2) Department ofHuman Genetic, KU Leuven School of medicine, 3000 Leuven,Belgium.

752BRegulation of seven-up expression in distinct mesodermal andnon-mesodermal derivatives of Drosophila melanogaster.Kathryn M. Ryan, Richard M. Cripps. Dept of Biology, Universityof New Mexico, Albuquerque NM.

753CMathematical Modeling of Cis-Regulatory TranscriptionalGrammar in Drosophila. Rupinder Sayal1, Walid Fakhouri1,Ahmet Ay2, Evan Dayringer2, Jacqueline Dresch2, ChichiaChiu2, David Arnosti1. 1) Department of Biochemistry andMolecular Biology, Michigan State University, East Lansing, MI;2) Department of Mathematics, Michigan State University, EastLansing, MI.

754AConservation of function, but not sequence, in the D-Pax2sparkling enhancer. Christina I. Swanson, David Schwimmer,Scott Barolo. Cell Dev Biol, Univ Michigan, Ann Arbor, MI.

755BComplex Regulatory Circuitry, Structural Rules, and a NovelRemote Control Element Govern a Notch- and EGFR-RegulatedEye Enhancer. Christina I. Swanson, Nicole C. Evans, ScottBarolo. Cell Dev Biol, Univ Michigan, Ann Arbor, MI.

756CA study on the genetic basis for species-specific formation of amale-specific muscle. Sakino Takayanagi1, TamasLukacsovich2, Manabu Ote1, Gakuta Toba1, DaisukeYamamoto1. 1) Graduate School of Life Sciences, TohokuUniversity, Sendai, Miyagi, Japan; 2) Department ofDevelopmental and Cell Biology, University of California, Irvine.

757AIdentification of co-regulated genes and cis-regulatory modulesin Drosophila contractile cardiomyocytes. Maria Florencia Tevy1,Bruno Zeitouni2, Stein Aerts3, Delphine Potier2, ElisabettaTosi1, Bassem Hassan3, Michel Semeriva2, Maria Capovilla1,Laurent Perrin2. 1) Biology and Evolution, Dulbecco telethonInstitute, University of Ferrara, Ferrara, FE, Italy; 2)Developmental Biology Institute of Marseille-Luminy, CNRS,Marseille, France; 3) Laboratory of Neurogenetics, Dept. ofMolecular and Developmental Genetics, Leuven, Belgium.

758BEvolution of gene expression patterns of Drosophilasegmentation genes. Zeba Wunderlich, Kelly Eckenrode,Sivanne Pearl, Angela DePace. Systems Biology, HarvardMedical School, Boston, MA.

759CArgonaute2 suppresses Drosophila Fragile X expressionpreventing oogenesis and neurogenesis defects. BalpreetBhogal, Anita Pepper, Rebecca Beerman, Thomas Jongens.Department of Genetics, University of Pennsylvania,Philadelphia, PA 19104.

760ADrosophila Lamin C is linked to hormone signaling. G. K.Dialynas1, S. R. Schulze2, S. Speese3, B. Curio-Penny1, P. K.Geyer1, V. Budnik3, L. L. Wallrath1. 1) Department ofBiochemistry, University of Iowa, Iowa City; 2) Department ofBiology, Western Washington University, Bellingham, WA; 3)Department of Neurobiology, University of Massachusetts,Worcester.

761BTime, Sex, and Toxicity. Louisa A. Hooven, Laura Beaver, KatieSherman, Jaga Giebultowicz. Zoology, Oregon State University,Corvallis, OR.

762CSu(z)2 antagonizes Autoregulation of Myc in Drosophila. AbidKhan, Julie Goodliffe. Dept of Biology, University of NorthCarolina at Charlotte, Charlotte, NC 28223.

763AImprinting of the Y chromosome influences dosagecompensation: A new paradigm for imprinting in Drosophila.Debashish Menon, Victoria Meller. Dept. of Biological Sciences,Wayne State University, Detroit, MI.

764BDetecting cis-regulatory elements using micro-array data ofDrosophila pseudoobscura embryogenesis expression profile.Xiaochun Ni1,2, Kevin White1,2,3. 1) Ecology and Evolution, TheUniversity of Chicago, Chicago, IL; 2) Institute of Genomics andSystems Biology the University of Chicago and Argonne NationalLaboratory; 3) Department of Human Genetics, the Universityof Chicago.

765CNatural genetic variation in transcriptome reflects networkstructure inferred with major effect mutations: insulin / TOR andassociated phenotypes in Drosophila melanogaster. Sergey V.Nuzhdin1, Andrew Pickering1, Jenniffer Brisson1, Marta L.Wayne2, Lawrence Harshman3, Lauren McIntyre2. 1) MolecComputational Biol, Univ Southern California, Los Angeles, CA;2) Genetics Dept, Univ Florida at Gainsville, Gainsville, CA; 3)Biology Dept, Univ Nebraska at Lincoln, Lincoln, NE.

766AThe Drosophila LEM domain proteins, Bocksbeutel and Otefin,make overlapping contributions to nuclear lamina function.Belinda S. Pinto1, Shameika R. Wilmington2, Emma E. L.Hornick2, Lori L. Wallrath1,2, Pamela K. Geyer1,2. 1) MCBProgram, University of Iowa, Iowa City, IA; 2) Department ofBiochemistry, University of Iowa, Iowa City, IA.



767BMultiple microRNAs modulate Drosophila germline stem cellscell cycle via cyclin dependent kinase inhibitor, Dacapo/p21.Steven H. Reynolds, Jenn-Yah Yu, Hannele Ruohola-Baker.Department of Biochemistry Institute for Stem Cell andRegenerative Medicine Room S581 UW Medicine at South LakeUnion 815 Mercer Street Seattle, WA 98109 Campus Mailbox:358056.

768CAnalyzing the role of the roX2 gene in establishing dosagecompensation. Charlotte Wang1, Artyom A. Alekseyenko1,2,Mitzi Kuroda1,2. 1) Department of Genetics, Harvard MedicalSchool, Boston, MA; 2) Harvard-Partners Center for Geneticsand Genomics, Division of Genetics, Dept. of Medicine, BrighamWomen's Hospital, Boston, MA.

769ADegringolade encodes an E3 ubiquitin ligase required for HESfamily repression. Kevin Barry1, Mona Abed2, Dorit Kenyagin2,Jeff Delrow1, Amir Orian2, Susan Parkhurst1. 1) FredHutchinson Cancer Research Center, Seattle, WA; 2) TechnionInstitute of Technology, Haifa, Israel.

770BFunctional Engrailed partners in DNA binding and repression ofthe sloppy-paired locus. Z. Cofer1, M. Fujioka1, X. Wu1, B.Gebelein2, J. B. Jaynes1. 1) Dept Biochem Molec Biol, ThomasJefferson Univ, Philadelphia, PA; 2) Div of Dev. Biol., CincinnatiChildren's Hosp, Cincinnati, OH.

771CEctopic expression of Myc can alter the endogenous expressionof Myc by auto-repression, stabilizing overall levels of Myc. KavehDaneshvar, Julie Goodliffe. University of North Carolina atCharlotte, Charlotte, NC.

772AExperimental and Theoretical Studies of the Yan Network.Thomas G. W. Graham1, Aaron Dinner2, Ilaria Rebay3. 1) TheCollege, Univ Chicago, Chicago, IL; 2) Department of Chemistry,Univ Chicago, Chicago, IL; 3) Ben May Inst Cancer Res, UnivChicago, Chicago, IL.

773BThe long-range corepressor Groucho is required for Knirpsmediated short-range repression. Sandhya Payankaulam,David Arnosti. Dept Biochem and Mol Biol, Michigan State Univ,East Lansing, MI.

774CSumoylation modulates Spalt activity. Jonatan Sánchez, AnaTalamillo, Coralia Pérez, Fernando Lopitz, Manuel Rodriguez,Rosa Barrio. CIC bioGUNE, Derio, Spain.

775ADrosophila SIN3 isoforms are found in distinct protein complexes.Marla M. Spain, Lori A. Pile. Department of Biological Sciences,Wayne State University, Detroit, MI.

776BInvestigating the Role of Drosophila SIN3 in Cell CycleRegulation. Aishwarya Swaminathan, Lori Pile. Biological Sci,Wayne State Univ, Detroit, MI.

777CSubdivision of the embryonic neurectoderm in Drosophilarequires Ind function to form and maintain boundaries of geneexpression. Tonia L. Von Ohlen, Cade M. Moses, Will Poulson.Div Biology, Kansas State Univ, Manhattan, KS.

RNA Biology

778AExpression, regulation and function of Drosophila miR-184. FredBiemar, Athenesia Faggins, Daphne Georlette. Departmentof Biology, Temple University, Philadelphia, PA.

779BThe conserved microRNA miR-8 Regulates SynapseMorphogenesis in Drosophila. Tudor A. Fulga, Carlos M. Loya,Cecilia Lu, Jannette Rusch, Janet Wang, David Van Vactor.Department of Cell Biology, Harvard Medical School, Boston,MA.

780CA mosaic screen aimed at identifying genes involved in miRNA-mediated gene regulation. Sigal Pressman, Richard Carthew.BMBCB, Northwestern University, Evanston, IL.

781AGenetic analysis of miRNA function in Drosophila melanogasteruncovered novel alleles of pasha(hDGCR8), Dicer-1, andputative miRNA pathway genes. C. A. Reinke, Matthew. G.Schwartz, Sigal Pressman, Richard Carthew. BMBCB,Northwestern University, Evanston, IL.

782BDrosophila let-7 microRNA is required for remodeling of theneuromusculature during metamorphosis. Nicholas S. Sokol.Deparment of Biology, Indiana University, Bloomington, IN.

783CmicroRNA star arms and anti-sense microRNAs in flies andmammals. Alexander Stark1,2,3, Natascha Bushati4,7, CalvinJan5, Pouya Kheradpour3, Emily Hodges6, Leo Parts3, JuliusBrennecke6, David Bartel5, Gregory Hannon6, StephenCohen4,7, Manolis Kellis2,3. 1) IMP, Vienna, Austria; 2) BroadInstitute of MIT and Harvard, Cambridge, MA; 3) CSAIL, MIT,Cambridge, MA; 4) EMBL, Heidelberg, Germany; 5) Departmentof Biology MIT, HHMI and Whitehead Institute for BiomedicalResearch, Cambridge, MA; 6) Watson School of BiologicalSciences and HHMI, Cold Spring Harbor, NY; 7) Temasek LifeSciences Laboratory, Singapore.

784ANoncoding roX1 RNA sequences that contr ibute to Xchromosome recognition. Ying Kong, Victoria Meller.Department of Biological Sciences, Wayne State University,Detroit, MI.

785BSignificant divergence of sex-related non-coding RNA expressionpatterns among closely related species in Drosophila. ZhengLi, Wenxia Zhang. School of Life Sciences, Peking University,Beijing, China.



786CFunctional characterization of the Drosophila MRP(mitochondrial RNA processing) RNA. Mary Schneider, AndrewSymes, Andie Bains, Andrew Simmonds. Department of CellBiology, Faculty of Medicine and Dentistry, University of Alberta,Edmonton, Canada.

787AControl of local mRNA translation in the Drosophila oocyte.Rebecca Bastock1, Maarten Zwart2, Daniel St. Johnston1. 1)Wellcome/CrUK Gurdon Institute, University of Cambridge,Cambridge, United Kingdom; 2) Dept. of Zoology, University ofCambridge, Cambridge, United Kingdom.

788BBicaudal-C and Ccr4 regulate nanos expression duringoogenesis. Chiara Gamberi, Paul Lasko. Dept Biol, McGill Univ,Montreal, PQ, Canada.

789CPost-transcriptional regulation of maternal RNAs by PUMILIOin Drosophila melanogaster. Mariana Kekis1, Hua Luo1, TimothyR. Hughes1,2, Howard D. Lipshitz1. 1) Department of MolecularGenetics University of Toronto Ontario, Canada; 2) Banting andBest Department of Medical Research University of TorontoOntario, Canada.

790AExamining the importance of ADAR auto-editing in Drosophila.Yiannis A. Savva1,2, James E. C. Jepson1,2, Robert A. Reenan1.1) Department of Molecular Biology, Cell Biology andBiochemistry, Brown University, Providence, RI; 2) These authorscontributed equally to this work.

791BAnalysis of tissue-specific requirements for the nonsensemediated mRNA decay pathway. Alexander Chapin, MarkMetzstein. Department of Human Genetics, University of Utah,Salt Lake City, UT.

792CA novel oskar mRNP component, Drosophila Ge-1, is requiredfor mRNA degradation in early embryos. Shih-Jung Fan, AnneEphrussi. Developmental Biology Unit, European MolecularBiology Laboratory, Heidelberg, Germany.

793AIn vivo analysis of cis and trans factors involved in nonsensemediated mRNA decay. Kimberly A. Frizzell, ShawnRynearson, Mark M. Metzstein. Dept Human Genetics, UnivUtah, Salt Lake City, UT.

794BAnalysis of Glutamate receptor transcript in the Drosophilaneuromuscular junction. Subhashree Ganesan, DavidFeatherstone. Department of Biological Sciences, UIC Chicago, IL.

795CLive imaging of nanos mRNA transport into nascent germ cells.Dorothy A. Lerit, Timothy T. Weil, Elizabeth R. Gavis.Department of Molecular Biology, Princeton University,Princeton, NJ.

796AThe GLS RNA element controls the localization and translationof gurken mRNA. Shengyin Lin1, Lan Lan2, Robert Cohen2. 1)Dept Neuroscience, Univ Toledo Med Ctr, Toledo, OH; 2)Molecular Biosciences, University of Kansas, Lawrence, KS.

797BMechanisms of Posterior Localization of Hsp83 mRNA. NajeebSiddiqui, Aaron Goldman, Angelo Karaiskakis, HowardLipshitz. Molecular Genetics, University of Toronto, Toronto, ON.,Canada.

798CCharacterization of trans-acting factors that mediate nanosmRNA localization. Kristina S. Sinsimer, Roshan A. Jain,Elizabeth R. Gavis. Molecular Biology, Princeton University,Princeton, NJ.

799AUnderstanding the ATP dependence of Dicer-2. Elif Sarinay,Phillip Zamore. Biochemistry and Molecular Pharmacology,Umass Medical School , Worcester , MA.

800BSystemic RNAi in insects. Yoshinori Tomoyasu1, Sherry Miller2,Susan Brown2. 1) Department of Zoology, Miami University,Oxford, OH; 2) DIvision of Biology, Kansas State University,Manhattan, KS.

801CSmall RNA-target RNA interactions determine the stability ofsmall silencing RNAs in Drosophila. Stefan L. Ameres1, MichaelHorwich1, Phillip D. Zamore1,2. 1) Department of Biochemistryand Molecular Pharmacology, University of MassachusettsMedical School, Worcester, MA-01605, USA; 2) Howard HughesMedical Institute.

802ADoes modification of U5 snRNA occur in the Cajal Body?Svetlana Deryusheva, Zehra Nizami, Joseph Gall. CarnegieInstitution for Science, Baltimore, MD.

803BImportin-β independent import of snRNPs in Drosophila.Amanda J. Hicks, Yu Chen, T. K. Rajendra, A. Gregory Matera.Dept Biology, Univ North Carolina, Chapel Hill, NC.

804CThe Drosophila HP1 homologue Rhino is required for piRNAbiogenesis, transposon silencing and genome maintenance inthe female germline. Carla Klattenhoff1, Nadine Schultz1,Jaspreet Khurana1, Birgit Koppetsch1, Chengjian Li2, HerveSeitz2, Hualin Xi3, Zhiping Weng3, Phillip Zamore2, WilliamTheurkauf1. 1) Program in Molecular Medicine and Program inCell Dynamics University of Massachusetts Medical SchoolWorcester MA, 01605; 2) Department of Biochemistry andMolecular Pharmacology University of Massachusetts MedicalSchool Worcester MA, 01605; 3) Program in Bioinformatics andIntegrative Biology University of Massachusetts Medical SchoolWorcester MA, 01605.



805AWithout the Argonaute3 protein, piRNA amplification andtransposon silencing collapse. Chengjian Li1,7, Vasia Vagin1,7,Soohyun Lee2, Jia Xu2, Shengmei Ma1, Herve Seitz1, MichaelHorwich1, Monika Syrzycka3, Barry Honda3, Ellen Kittler4,Maria Zapp4, Carla Klattenhoff5, Nadine Schultz5, WilliamTheurkauf5, Zhiping Weng6, Phillip Zamore1. 1) Departmentof Biochemistry and Molecular Pharmacology and HowardHughes Medical Institute, University of Massachusetts MedicalSchool, Worcester, MA; 2) Bioinformatics Program, Departmentof Biomedical Engineering, Boston University, Boston, MA; 3)Department of Molecular Biology and Biochemistry, SimonFraser University, Burnaby, BC, Canada; 4) Program in MolecularMedicine and Center for AIDS Research (CFAR), University ofMassachusetts Medical School, Worcester; 5) Program inMolecular Medicine, University of Massachusetts MedicalSchool, Worcester; 6) Program in Bioinformatics and IntegrativeBiology, University of Massachusetts Medical School, Worcester;7) These authors contributed equally to this work.

806BIsolating tissue specific regulatory proteins associated with theearly spliceosome. Thomas Joseph Carr, Alexis A. Nagengast.Dept Biochemistry, Widener Univ, Chester, PA.

807CA novel role for developmentally regulated dADAR isoforms inrnp-4f 5'-UTR intron splicing regulation. Jing Chen1, G. GirijaLakshmi1, Danielle L. Hays1, Katherine M. McDowell1, EnboMa2, Jack C. Vaughn1. 1) Dept Zoology, Miami Univ, Oxford,OH; 2) Dept Molecular and Cell Biology, Univ California atBerkeley, Berkeley, CA.

808AFunctional Analysis of a Non-Exonic Recursive Splice Site byGene Replacement. Michael Yen-Minn Chen, Steven Reilly,A. Javier Lopez. Dept Biological Sci, Carnegie Mellon Univ,Pittsburgh, PA.

809BPoly(ADP-ribosyl)ation of Heterogeneous NuclearRibonucleoproteins Modulates Alternative Splicing. Yingbiao Ji,Alexei Tulin. Dept Basic Sci, Fox Chase Cancer Ctr,Philadelphia, PA.

810CPPS is a co-transcriptional contributor to Sex-lethal alternativesplicing regulation. Matthew Logan Johnson, Alexis A.Nagengast, Helen K. Salz. Dept Genetics, Case WesternReserve U, Cleveland, OH.

811AUsing RNAi to Identify Tissue Specific Alternative Splicing Events.Tim Eric Rudolph1, Neha Sirohi2, Alexis Nagengast1. 1) DeptBiochemistry, Widener Univ, Chester, PA; 2) Dept Biology,Widener Univ, Chester, PA.

812BSplicing and a novel cis-acting element control oskar mRNAlocalization in Drosophila oocyte. Sanjay Ghosh, VirginieMarchand, Anne Ephrussi. Dev Biol, European Molec Biol Lab,Heidelberg, Germany.

Stem Cells

813CDirect Regulation of Pumilio Activity by bag-of-marbles andbenign gonial cell neoplasm. Song-ah Choi, Jiyoung Kim,Changsoo Kim. chonnam national university, gwangju.

814AThe role of insulin signaling in the regulation of germline stemcells. Therese M. Roth, Yukiko M. Yamashita. Life SciencesInstitute, Department of Cell Developmental Biology, Universityof Michigan, Ann Arbor, MI.

815BNucleoporin96 is required for maintaining germ line stem cellsin Drosophila. Cordula Schulz1, Benjamin B. Parrott1, YutingChiang2, Alicia Hudson1, Angshuman Sarkar3, AntoineGuichet4. 1) Department of Cellular Biology, University ofGeorgia, Athens, GA 30602; 2) Department of Psychology,Harvard University, Cambridge, MA 02138; 3) Cancer BiologyDepartment, Cleveland Clinic Foundation, Lerner ResearchInstitute, Cleveland, Ohio 44195; 4) Equipe Polarité etMorphogenèse Equipe Polarité et Morphogenèse, InstitutJacques Monod, 75251 Paris Cedex 05 France.

816CTuberous sclerosis complex maintains germline stem cells bypreventing differentiation. Pei Sun, Zhenghui Quan, RongwenXi. National Institute of Biological Sciences, Beijing, China.

817AMechanisms of germline stem cell maintenance during aging.Chihunt Wong1,2, Monica Boyle1, Leanne Jones1. 1) Laboratoryof Genetics, Salk Institute for Biological Studies, La Jolla, CA92037; 2) Department of Biology, University of California, SanDiego, La Jolla, CA.

818BdAtaxin-2 binding protein regulates stem cell differentiationduring Drosophila oogenesis. Omur Yilmaz, Michael Buszczak.Department of Molecular Biology, UT Southwestern MedicalCenter, Dallas, TX.

819CRegulation of neuroepithelial stem cell division patterns in opticlobe development and brain tumor formation. Aric L. Daul,Cheng-Yu Lee. Center for Stem Cell Biology, Life Science Inst.,University of Michigan, Ann Arbor, MI 48109.

820ARegulation of stem cell proliferation by CncC. Christine E.Hochmuth, Benoît Biteau, Heinrich Jasper. Department ofBiology, University of Rochester, Rochester, NY.

821BNiche-independent overproliferation and differentiation ofhematopoietic precursors generates dUbc9 tumors. MartaElzbieta Kalamarz1,2, Shubha Govind1,2. 1) Biology Department,The City College of New York, New York, NY; 2) The GraduateSchool and University Center of CUNY, New York, NY.



822CE-Cadherin creates a stable field for Notch signaling requiredfor differentiation from intestinal stem cell in adult Drosophilamodel. Kousuke Maeda, M. Takemura, M. Umemori, TakashiAdachi-Yamada. Department of Biology, Graduate School ofScience, Kobe University, Kobe, Japan.

823ACharacterization of Dedifferentiation as a Mechanism of GermLine Stem Cell Replacement in the Drosophila Testis Stem CellNiche. Rachel R. W. Stine, Erika L. Matunis. Johns HopkinsSchool of Medicine, Baltimore, MD.

824BEpigenetic regulation of reaper/hid expression in germ line andsomatic stem cells. Can Zhang1,2, Yanping Zhang1,2, NiaweiLin1,2, Lei Zhou1,2. 1) Molecular Genetics Microbiology, Collegeof medicine, Univ Florida, Gainesville, FL; 2) Shands CancerCenter, College of medicine, Univ Florida, Gainesville, FL.

825CGene Expression Profiles in the Germline Stem Cell Niche. AmyCash1, Justen Andrews1,2,3. 1) Dept. of Biology, IndianaUniversity, Bloomington, IN; 2) School of Informatics, IndianaUniversity, Bloomington, IN; 3) Center for Genomics andBioinformatics, Indiana University, Bloomington, IN.

826ASpindle repositioning during anaphase ensures asymmetric cystprogenitor cell division in the Drosophila testis. Jun Cheng1,Yukiko M. Yamashita2, Alan J. Hunt1. 1) Dept of BiomedicalEngineering; Center for Ultrafast Optical Science; 2) Center forStem Cell Biology, Life Sciences Institute; Dept of Cell andDevelopmental Biology, University of Michigan, Ann Arbor, MI.

827BModulation of germline stem cell division rate by the intracellularbacteria Wolbachia. Eva Fast, Kanchana Panaram, DanielleDesjardins, Barrett Steinberg, Horacio Frydman. Departmentof Biology, Boston University, Boston, MA.

828CInsulin signaling controls germline stem cell maintenance viathe niche. Hwei-Jan Hsu, Daniela Drummond-Barbosa.Department of Cell and Developmental Biology, VanderibiltMedical Center, Nashville, TN.

829AZfh-1 Controls Somatic Stem Cell Self-Renewal in the DrosophilaTestis and Nonautonomously Influences Germline Stem CellSelf-Renewal. Judith L. Leatherman, Stephen DiNardo. DeptCell Dev Biol, Univ Pennsylvania, Philadelphia, PA.

830BParacrine Wingless signaling controls intestinal stem cell self-renewal. Guonan Lin, Na Xu, Rongwen Xi. National Institute ofBiological Sciences, Beijing, China.

831CEGFR signaling and Drosophila female germline stem cell nicheactivity. Ming Liu1,2, Titmeng Lim2, William Chia1,2, Yu Cai1,2. 1)Temasek Lifesciences Laboratory, National University ofSingapore, Singapore; 2) Department of Biological Science,National University of Singapore, Singapore.

832AInfection Increases Stem Cell Proliferation to Promote IntestinalDysplasia In Drosophila. Yiorgos Apidianakis1,2,5, ChrysoulaPitsouli3,5, Norbert Perrimon3,4, Laurence Rahme1,2. 1) DeptSurgery, Massachusetts General Hospital, Harvard MedicalSchool, Boston, MA; 2) Shriners Hospital for Children, Boston,MA; 3) Dept Genetics, Harvard Medical School, Boston, MA; 4)Howard Hughes Medical Institute; 5) equal contributors.

833BJAK/STAT is restrained by Notch to control the proliferation ofDrosophila intestinal stem cells (ISCs). Wei Liu, Shree RamSingh, Steven Hou. Mouse Cancer Genetics Program, NCI/NIH, Frederick, MD.

834CInvestigating cell fate decisions of the intestinal stem cell.Carolina N. Perdigoto, Francois Schweisguth, Allison J.Bardin. Developmental Biology Department, Pasteur Institute,Paris, France.

835AMultiple roles of Wg signaling in the regulation of hematopoieticdevelopment of Drosophila. Sergey A. Sinenko1, LolitikaMandal1, Julian A. Martinez Agosto4, Utpal Banerjee1,2,3. 1)Department of Molecular, Cell and Developmental Biology,University of California, Los Angeles; 2) Molecular BiologyInstitute, University of California, Los Angeles; 3) Departmentof Biological Chemistry, University of California, Los Angeles; 4)Department of Human Genetics and Department of Pediatrics,David Geffen School of Medicine, University of California, LosAngeles.

836BStem cells in the fly hindgut. Shigeo Takashima, MariannaMkrtchyan, Amelia Younossi-Hartenstein, John Merriam,Volker Hartenstein. Dept of MCDB, UCLA, Los Angeles, CA.

837CA genetic screen identifies genes required intrinsically for FollicleStem Cell function in the Drosophila ovary. Zhu Wang, DanielKalderon. Dept Biological Sci, Columbia Univ, New York, NY.

Techniques and Functional Genomics

838AData integration and gene function prediction in Drosophilamelanogaster. James C. Costello1,2, Mehmet M. Dalkilic1,3,Justen Andrews1,2,3. 1) School of Informatics, Indiana University,Bloomington; 2) Dept of Biology, Indiana University, Bloomington;3) Center for Genomics and Bioinformatics, Indiana University,Bloomington.

839BFlyExpress: Bioinformatics for spatiotemporal patterns of geneexpression at a genomic scale in Drosophila embryogenesis.Sudhir Kumar1,2, FlyExpress Consortium. 1) Ctr Evol FuncGenomics, Arizona State Univ, Tempe, AZ; 2) School of LifeSciences, Arizona State Univ, Tempe, AZ.



840CRelationship of degrees of co-expression and sharedtranscription factor binding sites in Drosophila. Antonio Marco1,Charlotte Konikoff1,2, Sudhir Kumar1,2. 1) Biodesign Inst.,Arizona State University, Tempe, AZ; 2) School of Life Sciences,Arizona State University, Tempe, AZ.

841AFlyBase Search Tools - finding what you are looking for. PeterMcQuilton, FlyBase Consortium. Dept Genetics, UnivCambridge, Cambridge, United Kingdom.

842BThe Drosophila Gene Collection: Status and uses for functionalgenomics. Kenneth H. Wan, Charles Yu, Joseph W. Carlson,Xiao J. Chen, Ann Hammonds, Soo Park, Bayan Parsa,Jeremy Sandler, Richard Weiszmann, Susan Celniker. Dept.of Genome and Comp. Biol., Lawrence Berkeley NationalLaboratory, Berkeley, CA.

843CNon-lethal genotyping of individual flies. Gil B. Carvalho, WilliamW. Ja, Seymour Benzer. Division of Biology, California Instituteof Technology, Pasadena, CA 91125.

844AThe Bloomington Deletion and Duplication Projects. Kevin Cook,Stacey Christensen, Russell Garton, Adam Brown, Kim Cook,Thom Kaufman. Dept Biol, Indiana Univ, Bloomington, IN.

845BA powerful method combining homologous recombination andsite-specific recombination for targeted mutagenesis inDrosophila. Guanjun Gao, Conor McMahon, Jie Chen, YikangRong. LBMB/NCI, Bethesda, MD.

846CTesting the palindromic target site model for DNA transposoninsertion using the Drosophila melanogaster P-element. RaquelS. Linheiro, Casey M. Bergman. Faculty of Life Sciences,University of Manchester, United Kingdom.

847ADevelopment of a Somatic Assay for Testing HomingEndonuclease Activity in the Yellow Fever Mosquito, Aedesaegypti. Brenna E. Traver, Michelle A. E. Anderson, Zach N.Adelman. Entomology, Fralin Life Science Institute, VirginiaPolytechnic Institute and State University, Blacksburg, VA.

848BFlyAtlas.org: a comprehensive gene expression database ofDrosophila melanogaster tissues. Venkateswara R. Chintapalli1,Jing Wang1,2, Pawel Herzyk1,2, Julian Dow1. 1) Integrative andSystems Biology, University of Glasgow, Glasgow, UK; 2) SirHenry Welcome Functional Genomics Facility (SHWFGF),University of Glasgow, Glasgow, UK.

849CMeasuring and Modeling Allele Specific Expression using custommicroarrays. Lauren M. McIntyre1, Rita Graze1, Yajie Yang1,Marta Wayne1, Brandon Walts1, Bradley Main2, SergeyNuzhdin2. 1) Dept Molec Gen Micro, Univ Florida, Gainesville,FL; 2) USC Los Angeles, CA.

850AEstimation of errors introduced by confocal imaging into the dataon segmentation gene expression in Drosophila. M.Samsonova1, E. Myasnikova1, S. Surkova1, J. Reinitz2. 1) DeptComputational Biol, State Polytechnical Univ, St Petersburg,Russian Federation; 2) Stony Brook University, New York, USA.

851BEnd-on imaging provides a different perspective on Drosophiladorsoventral development. Melissa M. Witzberger1, James A.J. Fitzpatrick1,2, Justin C. Crowley1,3, Jonathan S. Minden1. 1)Department of Biological Sciences, Carnegie Mellon University,Pittsburgh, PA; 2) Molecular Biosensor and Imaging Center,Carnegie Mellon University, Pittsburgh, PA; 3) Center for theNeural Basis of Cognition, Carnegie Mellon University,Pittsburgh, PA.

852CA protein complex map of the Drosophila melanogasterinteractome. Guruharsha Kuthethur1, Joseph W. Carlson2,Odise Cenaj1, Xiao Chen2, Bhaveen Kapadia2, JulianMintseris1, Aijaz Noor3, Robert Obar1, Bayan Parsa2,Venkateshwara Reddy3, Jean-François Rual1, MarkStapleton2, Pujita Vaidya1, Kenneth Wan2, Charles Yu2, BoZhai1, K. VijayRaghavan3, Steven Gygi1, Susan Celniker2,Spyros Artavanis-Tsakonas1. 1) Department of Cell Biology,Harvard Medical School, Boston, MA; 2) Berkeley DrosophilaGenome Project, Lawrence Berkeley National Laboratory,Berkeley, CA; 3) National Centre for Biological Sciences, TataInstitute of Fundamental Research, Bangalore, India.

853AIn vivo detection of Transcription Factor-Target gene interactions.X.-J. Quan, S. Vankelst, E. Zaharieva, J.-K. Yan, N. De Geest,S. Reeve, B. Hassan. Human Genetics, Leuven University,Medicine School, Leuven, Belgium.

854BDesigning ts-Mutants in Drosophila. Joseph Lipsick, LauraAndrejka, Jonathan Ashton, Amy Wang. Pathology Genetics,Stanford Univ, Stanford, CA.

855CQuick, consistent, and easy automated DNA purification forDrosophila genotyping. R. Mann1, C. Staber2. 1) PromegaCorporation, Madison, WI; 2) Brown University, Providence, RI.

856AMultiplex High-Throughput Sequencing for Detection of GenomicVariation. Bryce Daines1, Hui Wang2, Yumei Li1,2, Yi Han2, RuiChen1,2. 1) Molecular and Human Genetics, Baylor College ofMedicine, Houston, TX; 2) Human Genome Sequencing Center,Baylor College of Medicine, Houston, TX.

857BDosage Compensation Complex binding sites are enriched withX-specific sequences. Miguel Gallach1, Vicente Arnau2,Ignacio Marin3. 1) Department of Biology. University of Texas,Arlington; 2) Departamento de Informatica, Universidad deValencia, Spain; 3) Instituto de Biomedicina de Valencia, Spain.



858CVersatile P(acman) BAC libraries for germ-line transformationstudies in Drosophila melanogaster. Roger A. Hoskins1, KoenJ. T. Venken2, Joseph W. Carlson1, Hongling Pan3, YuchunHe3, Rebecca Spokony4, Karen L. Schulze3, Kenneth H. Wan1,Maxim Koriabine5, Pieter J. de Jong5, Kevin P. White4, HugoJ. Bellen2,3,6. 1) Dept . of Genome Comput Biol, LawrenceBerkeley National Laboratory, Berkeley, CA; 2) Dept . of MolHuman Genet and Program in Dev Biol, Baylor College ofMedicine, Houston, TX; 3) HHMI, Baylor College of Medicine,Houston, TX; 4) Inst Genomics Systems Biol and Dept HumanGenet, University of Chicago, Chicago, IL; 5) Children's HospitalResearch Center, Oakland, CA; 6) Dept Neurosci, Baylor Collegeof Medicine, Houston, TX.

859AChloropyriphos induced tissue specific expression in UAS-GAL4Transgenic Drosophila melanogaster.. A. Kuman, R.Kumar. Zoology, Feroze Gandhi College Raebareli, UttarPradesh, India.

860BSpecific Cell Ablation in Drosophila Using Toxic Viral ProteinM2(H37A). Victoria K. Lam, Tsuyoshi Tokusumi, Robert A.Schulz. Biological Sciences, University of Notre Dame, NotreDame, IN.

861CProStack, a package to process digital images acquired withconfocal microscope. Maria Samsonova1, Konstantin Kozlov1,Andrei Pisarev1, John Reinitz2. 1) Dept Computational Biol,State Polytechnical Univ, St Petersburg, Russia; 2) Dept. ofApplied Math. and Statistics, Stony Brook University, NY.

862ARearrangements of Tpl and the Osiris gene cluster induced byFLP/FRT recombination. Victoria Broderick, Douglas R. Dorer.Department of Biology, Hartwick College, Oneonta, NY.

863BA transgenic sensor strain for monitoring the RNAi pathway inthe yellow fever mosquito, Aedes aegypti. Zach N. Adelman,Michelle A. E. Anderson, Elaine M. Morazzani, Kevin M.Myles. Dept Entomology, Virginia Tech, Blacksburg, VA.

864CSnapDragon: An on-line tool used to design dsRNAs forDrosophila melanogaster RNAi experiments. Matthew Booker1,Stephanie Mohr1, Norbert Perrimon1,2. 1) Drosophila RNAiScreening Center, Department of Genetics, Harvard MedicalSchool, Boston, MA; 2) Howard Hughes Medical Institute,Harvard Medical School, Boston, MA.

865ARNA interference of the Cytochrome P450 redox partners CPRand dare uncovers novel P450 functions in Drosophilamelanogaster. Thomas W. R. Harrop, Philip Batterham, PhillipJ. Daborn. Centre for Environmental Stress and AdaptationResearch (CESAR), Department of Genetics, Bio21 Molecularand Biotechnology Institute, The University of Melbourne,Victoria, 3010, Australia.

866BDissection of Synthetic Interaction Networks by RNAi. ThomasHorn1, Elin Axelsson2, Wolfgang Huber2, Michael Boutros1.1) Signaling Functional Gen, German Cancer Research Ctr,Heidelberg, Baden-Wuerttemberg, Germany; 2) EMBL -European Bioinformatics Institute, Wellcome Trust GenomeCampus, Cambridge CB10 1SD, UK.

867CGAL4-driver dependence of UAS-RNAi genetic screening.Christine Lesch, Juyeon Jo, Yujane Wu, Michael J. Galko.Department of Biochemistry Molecular Biology, UT M. D.Anderson Cancer Center, Houston, TX 77030, USA.

868ADrosophila RNAi Screening Center (DRSC): New Reagents,Protocols and Directions. Stephanie E. Mohr1, Stella Lee1,Matthew Booker1, Ian Flockhart1, Benjamin McElvany1,Quentin Gilly1, Hui Wang1, Michelle Ocana1, NorbertPerrimon1,2. 1) DRSC, Dept of Genetics, Harvard MedicalSchool, Boston, MA; 2) HHMI, Harvard Medical School, Boston,MA.

869BDesign of a second generation genome-wide RNAi library forDrosophila. Kerstin Spirohn1, Thomas Horn1, WolfgangHuber3, Amy Kiger2, Michael Boutros1. 1) Signaling andfunctional genomics, DKFZ, Heidelberg, Baden-Württemberg,Germany; 2) Department of Cell and Developmental Biology,University of California San Diego, 9500 Gilman Drive, La Jolla,California 92093, USA; 3) EMBL - European BioinformaticsInstitute, Wellcome Trust Genome Campus, Cambridge CB101SD, UK.

cell biology and signal transductiondepartment of molecular and cell biology 142 life sciences...

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