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Page 1: Cell Biology (Asistensi) Nopasswo

MUJOSEMEDILAB BIOLOGI FK UNS

Page 2: Cell Biology (Asistensi) Nopasswo

SCR BIOLOGIS DIKLASIFIKASIKAN 2 TIPE SEL :

04/22/232 BLOK 3 BIOLOGI MOLEKULER

Page 3: Cell Biology (Asistensi) Nopasswo

Sel (cell) : struktur dasar & unit fungsional dr kehidupan.

04/22/233 BLOK 3 BIOLOGI MOLEKULER

Page 4: Cell Biology (Asistensi) Nopasswo

1. Prokaryote Eubacteria :

•Org uniselluler.

•Tdk memp nukleus & organella.

•Memp khromosom tunggal (nucleoid) + plasmid

•DNA-nya sirkular, dg proporsi yg tinggi coding DNA & absence of repeats.

•Mis: bakt & cyanobacteria.

04/22/234 BLOK 3 BIOLOGI MOLEKULER

Page 5: Cell Biology (Asistensi) Nopasswo

2. Eukaryote

• Memp “nuclear envelope” & organella sel.

• Memp nucleolus (tempat ribosom dibentuk).

04/22/235 BLOK 3 BIOLOGI MOLEKULER

Page 6: Cell Biology (Asistensi) Nopasswo

Gbr : Sel hewan

04/22/236 BLOK 3 BIOLOGI MOLEKULER

Page 7: Cell Biology (Asistensi) Nopasswo

Gbr : Mikroskup Olympus tipe CX21

04/22/237 BLOK 3 BIOLOGI MOLEKULER

Page 8: Cell Biology (Asistensi) Nopasswo

JARINGAN DASAR :

1.Jaringan Epithel

2. Jaringan Pengikat & derivatnya.

3. Jaringan Otot

4. Jaringan Syaraf

04/22/238 BLOK 3 BIOLOGI MOLEKULER

Page 9: Cell Biology (Asistensi) Nopasswo

Copyright © 2006 Dr. Salme Taagepera, All rights reserved.

•Connective tissue supports other tissues and binds them together -bone, blood, and lymph tissues

•Epithelial tissue provides a covering -skin, the linings of the various passages inside the body

•Muscle tissue provide movement-striated (also called voluntary) muscles that move the skeleton

-smooth muscle, such as the muscles that surround the stomach-cardiac muscle

•Nerve tissue is made up of nerve cells (neurons) and is used to carry "messages" -brain (central nervous system) and spine (peripheral nervous system)

Four basic tissue types

Page 10: Cell Biology (Asistensi) Nopasswo

1.JARINGAN EPITHEL Sel epithel.

A.Sebagai Pelindung/Penutup

1.Simplex

a)Sel epith squamous (pipih) : lap parietal capsula Bowman ren

b)Sel epith kuboid : ep tubulus renalis & ep kelenjar thyroid

c)Sel epith kolumner (tabung) : villi intestinum tenue

04/22/2310 BLOK 3 BIOLOGI MOLEKULER

Page 11: Cell Biology (Asistensi) Nopasswo

2.Pseudocomplex/pseudostratified columnar

3.Complex/stratified (berlapis)a) Squamous (pipih) : dg kornifikasi & tanpa kornifikasib) Kuboidc) Kolumnerd) Transisional

B. Sebagai Kelenjar a. Endokrin : sel epith kelenjar thyroid.b. Eksokrin

04/22/2311 BLOK 3 BIOLOGI MOLEKULER

Page 12: Cell Biology (Asistensi) Nopasswo

Gbr : Berbagai tipe Epithel

04/22/2312 BLOK 3 BIOLOGI MOLEKULER

Page 13: Cell Biology (Asistensi) Nopasswo

FUNGSI EPITHEL :

a)Pelindung/proteksi : Epidermis, ep rongga mulut.

b)Sekresi : Ep kelenjar, mis. Kel thyroid.

c)Exkresi : ep. ginjal & epidermis (keringat).

d)Absorpsi : ep. intestinum

e)Pelicin/lubrikasi : ep. rectum.

f) Indera/penerima rangsang : ep. pengecap, pembau.

04/22/2313 BLOK 3 BIOLOGI MOLEKULER

Page 14: Cell Biology (Asistensi) Nopasswo

Gbr : Potongan Ginjal/Ren

04/22/2314 BLOK 3 BIOLOGI MOLEKULER

Page 15: Cell Biology (Asistensi) Nopasswo

Gbr : Epithel pipih selapisLap parietal Capsula Bowman Ren

04/22/2315 BLOK 3 BIOLOGI MOLEKULER

Page 16: Cell Biology (Asistensi) Nopasswo

Gbr : Epithel Cuboid Selapis : Tubulus Renalis04/22/2316 BLOK 3 BIOLOGI MOLEKULER

Page 17: Cell Biology (Asistensi) Nopasswo

Gbr : Epithel Kuboid Selapis : Kelenjar Thyroid

04/22/2317 BLOK 3 BIOLOGI MOLEKULER

Page 18: Cell Biology (Asistensi) Nopasswo

Gbr : Epithel Kelenjar thyroid.

1. Nucleus. 2. Massa koloid

← 1

2

1

2

04/22/2318 BLOK 3 BIOLOGI MOLEKULER

Page 19: Cell Biology (Asistensi) Nopasswo

Gbr : Ø lintang intestinum tenue

V : Villi.

V

04/22/2319 BLOK 3 BIOLOGI MOLEKULER

Page 20: Cell Biology (Asistensi) Nopasswo

N N : Nucleus sel epit kolumner villi intestinum tenue

Gbr : Villi intestinum tenue

04/22/2320 BLOK 3 BIOLOGI MOLEKULER

Page 21: Cell Biology (Asistensi) Nopasswo

2. JARINGAN PENGIKAT :

A. J P LonggarB. J LemakC. J P Fibrosa Padat : teratur & tak teratur.D. J Cartilago : C. hyalin, C. fibrosa, C. elasticE. J TulangF. J Hemopoietik

FUNGSI J P : sbg penyokong, penggantung, batas.

J P tdpt : sel-sel, serabut, dan substansi dasar

Serabut & substansi dasar membentuk matrix JP.04/22/2321 BLOK 3 BIOLOGI MOLEKULER

Page 22: Cell Biology (Asistensi) Nopasswo

J P Fibrosa padat teratur :

Cont : Tendo fx : melekatkan otot pd tulang.

• Serabut kolagen (dominan) : silindris pjg, sejajar, rapat berkas primer tendo srbt kolagen besar.

• Sel tendo (fibroblast) : pipih, diantara berkas primer tendo.

Gbr : Ø bujur Tendo04/22/2322 BLOK 3 BIOLOGI MOLEKULER

Page 23: Cell Biology (Asistensi) Nopasswo

F

CG

Gbr : Ø bujur tendo.

CG : Serabut Collagen. F : Sel tendo/fibroblas

04/22/2323 BLOK 3 BIOLOGI MOLEKULER

Page 24: Cell Biology (Asistensi) Nopasswo

Gbr : Ø bujur Tendo

04/22/2324 BLOK 3 BIOLOGI MOLEKULER

Page 25: Cell Biology (Asistensi) Nopasswo

Gbr : Ø bujur Tendo.

1. Sel Fibroblast. 2. Serabut kolagen

1

2

04/22/2325 BLOK 3 BIOLOGI MOLEKULER

Page 26: Cell Biology (Asistensi) Nopasswo

Gbr : Ø LINTANG TENDO

1. Sel tendo. 2. Jar Pengk Longgar.

04/22/2326 BLOK 3 BIOLOGI MOLEKULER

Page 27: Cell Biology (Asistensi) Nopasswo

J. Cartilago Hyalin :

a). Sel cartilago (chondrocyte) :

• dlm lacuna ; nucleus spheris/spt bola;

• makin ke perifer sel memipih;

• membelah sel isogen (nest) (mitosis 2 – 8 sel).

b). Substansi/matrix interselluler

• tdpt serabut collagen ; matrix teritorial tercat basophil kuat bungkus sel dsb capsula.

• matrix interteritorial tercat kurang basophil.

04/22/2327 BLOK 3 BIOLOGI MOLEKULER

Page 28: Cell Biology (Asistensi) Nopasswo

Gbr : Ø trachea. P : Perichondrium

P

04/22/2328 BLOK 3 BIOLOGI MOLEKULER

Page 29: Cell Biology (Asistensi) Nopasswo

Gbr : Cartilago hyalin.CB : Chondroblast. IG : Sel isogen. CL : Capsula

CB.

IG

CL

04/22/2329 BLOK 3 BIOLOGI MOLEKULER

Page 30: Cell Biology (Asistensi) Nopasswo

3. JARINGAN OTOT

A.Otot Polos (smooth muscle)

B.Otot Lurik (skeletal muscle)

C.Otot Cor (cardiac muscle)

Sel Otot Polos

• Ø bujur : btk fusiform/gelendong/spindle.

• Ø lintang : bulat, oval, atau pipih

• Non striated ; sitoplasma banyak

• Nucleus : sentral, mononuclear, oval/pipih/ memanjang

04/22/2330 BLOK 3 BIOLOGI MOLEKULER

Page 31: Cell Biology (Asistensi) Nopasswo

Gbr : Ø Otot polos pd Intestinum tenue.1. Potongan membujur. 2. Potongan melintang.

1 2

04/22/2331 BLOK 3 BIOLOGI MOLEKULER

Page 32: Cell Biology (Asistensi) Nopasswo

Gbr : Ø bujur sel otot polos1. Nucleus

1

04/22/2332 BLOK 3 BIOLOGI MOLEKULER

Page 33: Cell Biology (Asistensi) Nopasswo

Gbr : Ø Lintang sel otot polos04/22/2333 BLOK 3 BIOLOGI MOLEKULER

Page 34: Cell Biology (Asistensi) Nopasswo

B. Otot Lurik/Seranlintang/Rangka/Skelet

• Ø bujur : Silindris

• Ø lintang : bulat/oval.

• Nucleus : ditepi (dibawah sarcolemma/selaput

pembungkus sel), multinuclear, dan btknya :

oval/memanjang.

• Striated/lurik : segmen gelap (Anisotrop) dan

segmen terang (Isotrop).

04/22/2334 BLOK 3 BIOLOGI MOLEKULER

Page 35: Cell Biology (Asistensi) Nopasswo

• Myofibril : sel memanjang dg segmen gelap –

terang.

• Area Cohnheim : kelompokan fibril dlm

sarcoplasma (sitoplasma sel otot).

• Muscle fiber (serabut otot) diselubungi

endomysium perymisium epimysium.

04/22/2335 BLOK 3 BIOLOGI MOLEKULER

Page 36: Cell Biology (Asistensi) Nopasswo

04/22/2336 BLOK 3 BIOLOGI MOLEKULER

Page 37: Cell Biology (Asistensi) Nopasswo

GBR : Skematis Otot lurik04/22/2337 BLOK 3 BIOLOGI MOLEKULER

Page 38: Cell Biology (Asistensi) Nopasswo

Fig : Major Skeletal muscles in humans

04/22/2338 BLOK 3 BIOLOGI MOLEKULER

Page 39: Cell Biology (Asistensi) Nopasswo

Gbr : Ø bujur otot lurik1. Nucleus.

1

04/22/2339 BLOK 3 BIOLOGI MOLEKULER

Page 40: Cell Biology (Asistensi) Nopasswo

Gbr : Penampang lintang otot lurik

04/22/2340 BLOK 3 BIOLOGI MOLEKULER

Page 41: Cell Biology (Asistensi) Nopasswo

C. Otot Jantung/Cor

• Struktur myofibril spt otot lurik

• Memanjang, bercabang.

• Nucleus : ditengah, mononuclear (ada yg 2), elipsoid.

• Diameter ot cor atrial lbh kecil drpd otot cor ventricel.

• Striated : segmen gelap – terang.

• Discus intercalatus : hubungan antar sel dlm otot cor.

04/22/2341 BLOK 3 BIOLOGI MOLEKULER

Page 42: Cell Biology (Asistensi) Nopasswo

Gbr : Ø bujur Otot Jantung :

1. Nucleus. 2. Serabut otot. 3. Discus intercalatus

1

12

23

04/22/2342 BLOK 3 BIOLOGI MOLEKULER

Page 43: Cell Biology (Asistensi) Nopasswo

Gbr : Ø bujur Otot Jantung :1. Nucleus. 2. Serabut otot. 3. Discus intercalatus

1

2

3

04/22/2343 BLOK 3 BIOLOGI MOLEKULER

Page 44: Cell Biology (Asistensi) Nopasswo

Gbr : Ø lintang Otot jantung :Panah ganda : sel otot. Panah tunggal : nucleus

04/22/2344 BLOK 3 BIOLOGI MOLEKULER

Page 45: Cell Biology (Asistensi) Nopasswo

4. JARINGAN SYARAF

A. Systema Nervorum Central :

1) Cerebrum.

2) Cerebellum.

3) Medula spinalis.

B. Systema Nervorum Peripher

1

2

3

04/22/2345 BLOK 3 BIOLOGI MOLEKULER

Page 46: Cell Biology (Asistensi) Nopasswo

Neuron : kesatuan terkecil system syaraf, td :

badan sel dan processus protoplasmatis ( axon

& dendrit).

04/22/2346 BLOK 3 BIOLOGI MOLEKULER

Page 47: Cell Biology (Asistensi) Nopasswo

Tipe neuron :

1). Unipolar.

2). Pseudounipolar (T atau Y cell) (A).

3). Bipolar (B).

4). Multipolar (C).

04/22/2347 BLOK 3 BIOLOGI MOLEKULER

Page 48: Cell Biology (Asistensi) Nopasswo

a) Axon/Neurit :

• Sangat panjang, dg sedikit cabang

• Sbg penghantar impuls.

• Axon hillock : pangkal axon yg berbtk kerucut.

b)Dendrit :

• Pendek, bercabang.

• Penerima rangsang dr neuron lain.

• Tdp. Nissl body (kecuali pd cabang yg halus).

Nucleus : Spheris, sentral, mononuclear.

04/22/2348 BLOK 3 BIOLOGI MOLEKULER

Page 49: Cell Biology (Asistensi) Nopasswo

1.CEREBRUM

a. Cortex (gray matter). b. Medulla (white matter).

Pd Cortex terdpt sel :

1. Pyramid.

2. Stelat.

3. Fusiform.

4. Horizontal.

5. Polygonal.

04/22/2349 BLOK 3 BIOLOGI MOLEKULER

Page 50: Cell Biology (Asistensi) Nopasswo

Letak sel :I. Str moleculare : sel 2

& 4.II. Str granulosum ext :

sel 1 (kecil).III.Str pyramydale ext :

sel 1 (medium+besar).

IV. Str granulosum int : sel multipolar.V. Str pyramidale int : giant pyramidale cell.VI. Str multiforme : sel 3 & 5.

04/22/2350 BLOK 3 BIOLOGI MOLEKULER

Page 51: Cell Biology (Asistensi) Nopasswo

Gbr : Ø Cerebrum 1. Sel Pyramid. 2. Apical dendrite

1

1

2

2

1

04/22/2351 BLOK 3 BIOLOGI MOLEKULER

Page 52: Cell Biology (Asistensi) Nopasswo

2. CEREBELLUM

a). Cortex (subst griscea) td :

1) Str. Moleculare : sel stelat.

2) Str. Ganglionare/Purkinje cell layer : sel botol / Purkinje.

Cerebellum

3)Str. Granulosum/ granulare : sel granula.

Gbr : Ø Cerebellum

04/22/2352 BLOK 3 BIOLOGI MOLEKULER

Page 53: Cell Biology (Asistensi) Nopasswo

Gbr : Stratifikasi korteks (gray matter/ subst. griscea) cerebellum

04/22/2353 BLOK 3 BIOLOGI MOLEKULER

Page 54: Cell Biology (Asistensi) Nopasswo

Gbr : Sel-sel Purkinje

04/22/2354 BLOK 3 BIOLOGI MOLEKULER

Page 55: Cell Biology (Asistensi) Nopasswo

3. MEDULA SPINALIS• Subst griscea/gray matter (spt huruf H) dikelilingi subst

alba/white matter.• Cornu posterior/dorsal horn : pjg mencapai permkan dg

sel motorik kecil.• Cornu anterior /ventral horn: lebar, pendek (tdk

mencapai permkan) dg sel motorik besar.• Neuron : tipe multipolar (dendrit > 1 & neurit =1).• Nucleus : bulat, besar dg nucleolus.• Neuroplasma dg Nissl body.

04/22/2355 BLOK 3 BIOLOGI MOLEKULER

Page 56: Cell Biology (Asistensi) Nopasswo

2 2

1 1

Gbr : Ø lintang Medula spinalis 1. Dorsal horn /cornu post. 2. Ventral horn/cornu ant.

04/22/2356 BLOK 3 BIOLOGI MOLEKULER

Page 57: Cell Biology (Asistensi) Nopasswo

Gbr : Motor neurons04/22/2357 BLOK 3 BIOLOGI MOLEKULER

Page 58: Cell Biology (Asistensi) Nopasswo

5. JARINGAN HEMOPOIETIC

Td :

a) Serabut (ktk membeku).

b) Plasma drh.

c) Corpuscula drh :

• Erythrocyte;

• Leucocyte;

• Thrombocyte.

04/22/2358 BLOK 3 BIOLOGI MOLEKULER

Page 59: Cell Biology (Asistensi) Nopasswo

A. Erythrocyte• Merah Hb (pigmen pernafasan).• Mammalia : btk biconcave (vertebrata non mammalia : elips,

bernucleus).• Ukuran :segar Ө 8.5 μm prep smear Ө 7.6 μm.• Central pallor (bag tengah erythocyt) pucat.• Reuleaux formation bergandengan.• Siklus hidup ± 120 hari

04/22/2359 BLOK 3 BIOLOGI MOLEKULER

Page 60: Cell Biology (Asistensi) Nopasswo

B. Leucocyte

1. Agranulocyte

a). Lymphocyte (25%) Peran dlm kekebalan tbh

• Ө 7 – 8 μm. • Nucleus besar, spheris, padat & gelap (ms chromatin).

• Sit. tipis, basophilic biru.

L : LymphocyteCP : Central pallor (Erythrocyte)CP

L

Gbr : Apusan darah (Lymphocyte & RBC)

04/22/2360 BLOK 3 BIOLOGI MOLEKULER

Page 61: Cell Biology (Asistensi) Nopasswo

b) Monocyte (5%)

• phagocytosis dlm jar macrophage.

• Ukuran : 9 -12 μm

• Nucleus : ovoid, ginjal, huruf U, eksentris.

• Sitoplasma : lbh banyak, abu-abu, biru keruh.P : Platellet.M : Monocyte.RF : Reuleaux formation.R : RBC.

Gbr : Apusan darah (Monocyte & RBC)RFRF

04/22/2361 BLOK 3 BIOLOGI MOLEKULER

Page 62: Cell Biology (Asistensi) Nopasswo

2. Granulocyte

a).Eosinophil (3%) : allergi phagocytosis (kompleks antigen - antibodi).

• Granula besar, bulat, uniform menyerap zat warna asam : merah – orange.

• Ukuran : 9 μm (2 x RBC).

• Nucleus : bilobus.

Gbr : Apusan darah (Eosinophil &

RBC)

04/22/2362 BLOK 3 BIOLOGI MOLEKULER

Page 63: Cell Biology (Asistensi) Nopasswo

b) Basophil (0.5%) : mampu phagocytosis• Ukuran = neutrophil.• Nucleus : 2 - 3 lobi, spt U atau S, kdg tdk kelihatan.

• Granula : bulat, kasar, menyerap zat warna basa biru tua – purple.

Gbr : Apusan darah (Basophil & RBC)

04/22/2363 BLOK 3 BIOLOGI MOLEKULER

Page 64: Cell Biology (Asistensi) Nopasswo

c).Neutrophil (65%) phagocytosis bakteri & benda asing.• Ukuran : 10 – 12 μm. • Nucleus : - batang /stab muda.

- segmen (3 – 5) tua PMN.

• Granula : halus me- nyerap zat warna netral.

• ♀ nucleus memp drumstick (tonjolan khromatin).Gbr : Apusan darah.

P : Platellet (thrombocyte), R : RBC, N : Neutrophil.

04/22/2364 BLOK 3 BIOLOGI MOLEKULER

Page 65: Cell Biology (Asistensi) Nopasswo

C. Thrombocyte

• Merup keping-keping sitoplasma sel raksasa

(megakaryocyte) dlm susmsum tulang.

• Btk : bulat, discus (biconvex), tdk berwarna, tdk

bernucleus, ktk difiksasi stellate

• Ukuran : 2 – 3 μm

• Juml. (manusia) : 200 -300 ribu/mm cu.

04/22/2365 BLOK 3 BIOLOGI MOLEKULER

Page 66: Cell Biology (Asistensi) Nopasswo

• Dicat Rumanowsky 2 bag berbeda.

◦ Tengah (tebal) mengandung granula kecil kekuningan

granulomer/chromatomer. Granulomer kecil (0.2 – 0.3

μm) granula alfa

◦ Tepi (tipis) homogen, biru pucat, dsb hialomer.

• Masa hidup : 9 -10 hari diphagocyte macrophage.

04/22/2366 BLOK 3 BIOLOGI MOLEKULER

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04/22/2367 BLOK 3 BIOLOGI MOLEKULER