cell death slides.ppt - indiana university...
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HypertrophyHypertrophy HyperplasiaHyperplasia AtrophyAtrophy
Responses to StressResponses to Stress
AtrophyAtrophy MetaplasiaMetaplasia
HypertrophyHypertrophy
Cardiac HypertrophyCardiac Hypertrophy
Increased numbersIncreased numbers Cell Cycle and HyperplasiaCell Cycle and Hyperplasia
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Cell SignalingCell Signaling Liver RecoveryLiver Recovery
Compensatory HyperplasiaCompensatory Hyperplasia Compensatory HyperplasiaCompensatory Hyperplasia
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AtrophyAtrophyAtrophyAtrophy
MetaplasiaMetaplasia
Injury and Cell DeathInjury and Cell Death
InjuryInjury ReversibleReversible IrreversibleIrreversible
Cell DeathCell Death “Bring out your Dead”“Bring out your Dead”
Types of InjuryTypes of Injury
HypoxicHypoxic Physical agentsPhysical agents ChemicalChemical InfectiousInfectious ImmunologicalImmunological GeneticGenetic NutritionalNutritional NeoplasticNeoplastic PsychiatricPsychiatric
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Dead and NearDead and Near--DeadDead
All InterconnectedAll Interconnected
A real surgeryA real surgery
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Dead and NearDead and Near--DeadDeadTakes TimeTakes Time
Reversible +/Reversible +/-- SwellingSwelling VacuolesVacuoles VacuolesVacuoles Membrane blebsMembrane blebs Mitochondria changesMitochondria changes
Dead cell, necrosisDead cell, necrosis AutolysisAutolysis Nuclear disintegrationNuclear disintegration
Nuclear PyknosisNuclear Pyknosis
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Renal tubular cell death.Renal tubular cell death. PyknosisPyknosis
Renal tubular cell death.Renal tubular cell death.
Gangrenous necrosisGangrenous necrosis Not too specificNot too specific Subset of Subset of coagulativecoagulative necrosisnecrosis Gets infectedGets infected
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FibrinoidFibrinoid An An exudateexudate, not really a special form of , not really a special form of
necrosis.necrosis. Results from “immune complexResults from “immune complex” injury.” injury.
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Two Ways, Same EndTwo Ways, Same End
ApoptosisApoptosis ExtrinsicExtrinsic
Signaling proteinsSignaling proteins TNFTNF
IntrinsicIntrinsic MitochondrialMitochondrial
When to replace?When to replace?
Intrinsic apoptosisIntrinsic apoptosis Extrinsic apoptosisExtrinsic apoptosis
No InflammationNo Inflammation
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Funky MitochondriaFunky Mitochondria Cytoskeletal ProteinsCytoskeletal Proteins
Cellular VacuolesCellular Vacuoles Fatty MetamorphosisFatty Metamorphosis
XanthomasXanthomas
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Fatty InfiltrationFatty Infiltration
Protein AccumulationProtein Accumulation AlphaAlpha--11--Antirypsin DeficiencyAntirypsin Deficiency
PigmentsPigmentsCoal Worker’s LungCoal Worker’s Lung