Cell Division and Apoptosis II
chapter 17
Activation of a cyclin dependent kinase
CdK activity can be suppressed by inhibitory phosphorylation
CdK activity can be suppressed by inhibitory proteins
Assembly of pre-replicative complex during G1 phase
Entry into mitosis is blocked by incomplete DNA replication
Hydroxyurea blocks DNA synthesisCaffeine causes failure of checkpoint
The Rb protein acts as a brake in mammalian cells
Overview of cell cycle control system
Programmed Cell Death - Apoptosis
Digits in developing mouse paw are formed through apoptosis
cells undergoing apoptosis
Apoptosis causes tadpole to lose tail
Procaspase is activated by an active caspase
Caspase cascade occurs during apoptosis
An animal cell depends on extracellular signals to survive or divide
An animal cell depends on extracellular signals to differentiate. Without extracellular signals the
cell will die
Platelet derived growth factor was the first mitogen isolated
stimulates cell division during wound healing
Mitogens stimulate G1-Cdk and G1/S-Cdk activities