cell division and growth control 2 3 1 moderator: thomas neufeld

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25 PLATFORM SESSIONS Program number is in bold above the title. The first author is the presenter. Abstracts begin on page 79. Thursday, March 30: 4:30 pm–6:30 pm Ballroom of the Americas A-C Cell Division and Growth Control Moderator: Thomas Neufeld, University of Minnesota, Minneapolis 1 - 4:30 Drosophila TCTP Regulates Cell Growth and Proliferation by Acting as a Guanine Nucleotide Exchange Factor for the Rheb GTPase. Ya-Chieh Hsu 1 , Joshua Chern 2 , Yi Cai 3 , Mingyao Liu 3 , Kwang-Wook Choi 1,2,4 . 1) Program in Developmental Biology, Baylor College of Medicine; 2) Department of Molecular and Cellular Biology, Baylor College of Medicine; 3) Department of Medical Biochemistry and Genetics, Alkek Institute of Biosciences and Technology, Texas A&M University System Health Science Center; 4) Department of Ophthalmology, Baylor College of Medicine Houston, TX. 2 - 4:45 The tumor suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Fisun Hamaratoglu 1,2 , Maria Willecke 1 , Madhuri Kango-Singh 1 , Riitta Nolo 1 , Georg Halder 1,3 . 1) Dept Biochem & Molec Biol, MD Anderson Cancer Ctr, Houston, TX; 2) Prog in Developmental Biology, Baylor College of Medicine, Houston, TX; 3) Prog in Genes and Development, University of Texas M. D. Anderson Cancer Ctr, Houston, TX. 3 - 5:00 Phosphorylation and activity of the tumor suppressor Merlin and the ERM protein Moesin are co-ordinately regulated by the SLIK kinase. Sarah C. Hughes, Richard G. Fehon. Depart. Mol. Gen. and Cell Bio., University of Chicago, Chicago, IL. 4 - 5:15 The growth regulator dMyc functions in part independently of dMax. Dominik D. Steiger 1 , Sarah Pierce 2 , Robert N. Eisenman 2 , Peter Gallant 1 . 1) Zoological Institute, University of Zurich, Zurich, Switzerland; 2) Fred Hutchinson Cancer Research Center, Division of Basic Sciences, Seattle, WA. 5 - 5:30 Identification of genes required for Myc-induced cell growth. Julie Secombe, Leni Carlos, Robert Eisenman. Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA. 6 - 5:45 The Drosophila condensin subunit CapH2 ensures faithful separation of male meiotic chromosomes. Tom Hartl, Sarah Sweeney, Paula Campbell, Giovanni Bosco. Dept Molec & Cellular Biol, Univ Arizona, Tucson, AZ. 7 - 6:00 An essential meiotic function for the INCENP chromosome passenger protein in sister-chromatid cohesion. Tamar Resnick 1 , David Satinover 2 , Fiona MacIsaac 3 , Todd Stukenberg 2 , William Earnshaw 3 , Terry Orr-Weaver 1 , Mar Carmena 3 . 1) Whitehead Institute and Dept Biology, MIT, Cambridge, MA; 2) University of Virginia, Dept Biochemistry and Molecular Genetics, Charlottesville, VA; 3) Wellcome Trust Centre for Cell Biology, School of Biology, University of Edinburgh, Edinburgh, UK. 8 - 6:15 Mutation of corona reveals an SC-independent role for C(3)G in maintaining meiotic chromosome pairing. Scott L. Page, R. Scott Hawley. Stowers Institute for Medical Research, Kansas City, MO.

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Page 1: Cell Division and Growth Control 2 3 1 Moderator: Thomas Neufeld

25PLATFORM SESSIONS

Program number is in bold above the title. The first author is the presenter. Abstracts begin on page 79.

Thursday, March 30: 4:30 pm–6:30 pmBallroom of the Americas A-C

Cell Division and Growth Control

Moderator: Thomas Neufeld, University of Minnesota,Minneapolis

1 - 4:30Drosophila TCTP Regulates Cell Growth and Proliferation byActing as a Guanine Nucleotide Exchange Factor for the RhebGTPase. Ya-Chieh Hsu1, Joshua Chern2, Yi Cai3, MingyaoLiu3, Kwang-Wook Choi1,2,4. 1) Program in DevelopmentalBiology, Baylor College of Medicine; 2) Department ofMolecular and Cellular Biology, Baylor College of Medicine;3) Department of Medical Biochemistry and Genetics, AlkekInstitute of Biosciences and Technology, Texas A&M UniversitySystem Health Science Center; 4) Department ofOphthalmology, Baylor College of Medicine Houston, TX.

2 - 4:45The tumor suppressor genes NF2/Merlin and Expanded actthrough Hippo signalling to regulate cell proliferation andapoptosis. Fisun Hamaratoglu1,2, Maria Willecke1, MadhuriKango-Singh1, Riitta Nolo1, Georg Halder1,3. 1) Dept Biochem& Molec Biol, MD Anderson Cancer Ctr, Houston, TX; 2) Progin Developmental Biology, Baylor College of Medicine,Houston, TX; 3) Prog in Genes and Development, Universityof Texas M. D. Anderson Cancer Ctr, Houston, TX.

3 - 5:00Phosphorylation and activity of the tumor suppressor Merlinand the ERM protein Moesin are co-ordinately regulated bythe SLIK kinase. Sarah C. Hughes, Richard G. Fehon. Depart.Mol. Gen. and Cell Bio., University of Chicago, Chicago, IL.

4 - 5:15The growth regulator dMyc functions in part independently ofdMax. Dominik D. Steiger1, Sarah Pierce2, Robert N.Eisenman2, Peter Gallant1. 1) Zoological Institute, Universityof Zurich, Zurich, Switzerland; 2) Fred Hutchinson CancerResearch Center, Division of Basic Sciences, Seattle, WA.

5 - 5:30Identification of genes required for Myc-induced cell growth.Julie Secombe, Leni Carlos, Robert Eisenman. BasicSciences, Fred Hutchinson Cancer Research Center, Seattle,WA.

6 - 5:45The Drosophila condensin subunit CapH2 ensures faithfulseparation of male meiotic chromosomes. Tom Hartl, SarahSweeney, Paula Campbell, Giovanni Bosco. Dept Molec &Cellular Biol, Univ Arizona, Tucson, AZ.

7 - 6:00An essential meiotic function for the INCENP chromosomepassenger protein in sister-chromatid cohesion. TamarResnick1, David Satinover2, Fiona MacIsaac3, ToddStukenberg2, William Earnshaw3, Terry Orr-Weaver1, MarCarmena3. 1) Whitehead Institute and Dept Biology, MIT,Cambridge, MA; 2) University of Virginia, Dept Biochemistryand Molecular Genetics, Charlottesville, VA; 3) Wellcome TrustCentre for Cell Biology, School of Biology, University ofEdinburgh, Edinburgh, UK.

8 - 6:15Mutation of corona reveals an SC-independent role for C(3)Gin maintaining meiotic chromosome pairing. Scott L. Page, R.Scott Hawley. Stowers Institute for Medical Research, KansasCity, MO.

Page 2: Cell Division and Growth Control 2 3 1 Moderator: Thomas Neufeld

26 PLATFORM SESSIONS

Program number is in bold above the title. The first author is the presenter. Abstracts begin on page 79.

Thursday, March 30: 4:30 pm–6:30 pmBallroom of the Americas D-F

Evolution and Quantitative Genetics

Moderator: Greg Gibson, North Carolina State University,Raleigh

9 - 4:30Joint estimates of the effects and frequencies of QTL usingsynthetic recombinant populations of Drosophila. Stuart J.Macdonald, Anthony D. Long. Dept. Ecology & Evolution,University of California, Irvine, CA.

10 - 4:45Population genetic analyses of a thermal QTL in experimentaland natural populations of D. melanogaster. David Rand1,Colin Meiklejohn1, Donna Folk2, Reid Hopkins1, DanielSolomon1, Daniel Weinreich1, George Gilchrist2. 1) Ecology& Evolutionary Biol, Brown Univ, Providence, RI; 2) Departmentof Biology, William and Mary, Williamsbug, VA.

11 - 5:00Tales from the X files: chromosomal context, dosagecompensation, and gene expression. Marta Wayne1, MarinaTelonis-Scott1, Lisa Bono2, Lawrence Harshman3, ArtyomKopp4, Sergey Nuzhdin4, Lauren McIntyre2. 1) Zoology,University of Florida, Gainesville, FL; 2) Agronomy, PurdueUniversity, W. Lafayette, IN; 3) School of Biological Sciences,U. Nebraska, Lincoln, NE; 4) Evolution and Ecology, UC Davis,Davis, CA.

12 - 5:15Role of Natural Selection in the Evolution of Gene Expression.Alisha K. Holloway1, Jason G. Mezey2, Corbin D. Jones3. 1)Evolution & Ecology, Univ California-Davis, Davis, CA; 2)Biological Statistics, Cornell University, NY; 3) Department ofBiology, University of North Carolina-Chapel Hill, Chapel Hill,NC.

13 - 5:30Evolutionary modification of Hox-free dorsal appendages ina beetle Tribolium castaneum. Yoshinori Tomoyasu, Robin E.Denell. Div Biol, Kansas State Univ, Manhattan, KS.

14 - 5:45The genetic architecture of hybrid male sterility. Laura Reed,Brooke LaFlamme, Therese Markow. Dept EEB, Univ Arizona,Tucson, AZ.

15 - 6:00An HP1 interacting protein causes hybrid lethality between D.melanogaster and D. simulans. Daniel A. Barbash, NicholasJ. Brideau, Jun Wang, Heather A. Flores, Adam G. Diehl,Shamoni Maheshwari. Dept Molecular Biol & Genetics,Cornell Univ, Ithaca, NY.

16 - 6:15Molecular population genetics of incipient speciation.Anthony Greenberg, Joshua Shapiro, Hurng-Yi Wang,Chung-I Wu. Dept Ecology & Evolution, The University ofChicago, Chicago, IL.

Thursday, March 30: 4:30 pm–6:30 pmLanier Grand Ballroom A-B

Neurogenetics and Neural Development

Moderator: Kwang-Wook Choi, Baylor College ofMedicine, Houston, Texas

17 - 4:30Non-Canonical signaling of BMP ligands through an Activin-type pathway regulates brain lobe development andphotoreceptor axon targeting in Drosophila. Changqi C. Zhu1,Osamu Shimmi1,2, Michael B. O’Connor1,2. 1) Dept ofGenetics, Cell Biology and Development, University ofMinnesota, 6-160 Jackson Hall, Minneapolis, MN 55455; 2)Howard Hughes Medical Institute, University of Minnesota, 6-160 Jackson Hall, Minneapolis, MN 55455.

18 - 4:45The novel secreted glial factor Tangled interacts with the Roboreceptors to position longitudinal axon tracts in the embryonicnervous system. Tirtha K. Das, Dan Leaman, Ulrike Gaul.Developmental Neurogenetics, Rockefeller University, NewYork, NY.

19 - 5:00Dendrite Morphogenesis: Role of cytoskeletal molecule,Diaphanous. Madhuri Shivalkar, Gaia Tavosanis. MolecularNeurobiology, Max Planck Institute of Neurobiology, Munich,Germany.

20 - 5:15A novel POU gene acts in odor receptor gene choice. AndreaL. Tichy, Anandasankar Ray, John R. Carlson. MCDB, YaleUniversity, New Haven, CT.

21 - 5:30Rumi, a protein with homology to bacterial polysaccharidemodifiers, is a general regulator of Notch signaling inDrosophila. Hamed Jafar-Nejad1,5, Melih Acar2,5, AkhilaRajan1, Vafa Bayat3, Dafina Ibrani1, Hongling Pan1, HugoBellen1,2,3,4. 1) Department of Molecular & Human Genetics; 2)Program in Developmental Biology; 3) Medical ScientistTraining Program; 4) Howard Hughes Medical Institute, BaylorCollege of Medicine, Houston, TX 77030; 5) equal contribution.

22 - 5:45Numb regulates R3/R4 specification and the establishmentof planar cell polarity in the Drosophila eye. Pedro Domingos,Hermann Steller, Bertrand Mollereau. Steller Laboratory,Rockefeller Univ, New York, NY.

23 - 6:00Roles for the Tumor Suppressor Genes AdenomatousPolyposis Coli 1 and 2 in Cell Adhesion and Axon Outgrowthin the Developing Larval Brain. Melissa Hayden, KathrynAkong, Mark Peifer. Curriculum in Genetics, University ofNorth Carolina, Chapel Hill, NC.

Page 3: Cell Division and Growth Control 2 3 1 Moderator: Thomas Neufeld

27PLATFORM SESSIONS

Program number is in bold above the title. The first author is the presenter. Abstracts begin on page 79.

24 - 6:15Discovery and Characterization of Genes involved in de novoformation of Drosophila NMJs. Ghulam M. Lone1, ZoltanAsztalos2, Richard Auburn2, Wolfgang Bottenberg1, RichardKammerer1, Cahir O’Kane2, João Rocha2, Sean T. Sweeney3,Mingyao Yang4, Andreas Prokop1. 1) Faculty of Lifesciences,Univ. Manchester; 2) Department of Genetics, Univ. Cambridge,UK; 3) University of York, York, UK; 4) MRC Dunn HumanNutrition Unit, Wellcome Trust/MRC Building, Cambridge, UK.

Friday, March 31: 8:30 am–10:15 amLanier Grand Ballroom A-B

Cytoskeleton and Cellular Biology

Moderator: David Bilder, University of California-Berkeley

25 - 8:30The lipid droplet proteome: droplets as a storage depot.Michael Welte1, Silvia Cermelli2, Yi Guo1, Steven Gross2. 1)Brandeis Univ, Waltham, MA; 2) University of California, Irvine,CA.

26 - 8:45Fragile X mental retardation protein 1 (FMR1) is required forDrosophila cellularization. O. Papoulas, K. Monzo, Y. Wang,J. C. Sisson. The Section of MCD Biology and The Insitute forCellular and Molecular Biology, The University of Texas atAustin, Austin, TX.

27 - 9:00Identification of genes involved in integrin-mediated cellspreading. Klodiana Jani, Frieder Schöck. Stewart BiologyBuilding, McGill University, Montreal, Quebec, Canada.

28 - 9:15The Role of Canoe in Morphogenesis. Jessica K. Sawyer1,Ulrike Gaul2, Mark Peifer1. 1) Dept Biol, Univ North Carolina,Chapel Hill, NC; 2) Laboratory of DevelopmentalNeurogenetics, Rockefeller Univ, NY.

29 - 9:30A screen for epithelial defects in the Drosophila ovary revealsa role for cytoplasmic Dynein in the targeting of apical proteins.Sally Horne-Badovinac, David Bilder. Department ofMolecular & Cell Biology, University of California, Berkeley,Berkeley, CA.

30 - 9:45Kelch Functions with Cullin3 to Remodel F-Actin in OvarianRing Canals. Andrew Hudson, Lynn Cooley. Yale Univ Schoolof Medicine, New Haven, CT.

31 - 10:00Function of DExo84 in maintenance of adherens junctionsand apical identity in epithelial cell polar ity. JamesBlankenship1, Margaret Fuller2, Jennifer Zallen1. 1) DeptDevelopmental Biol, Sloan-Kettering Institute, New York, NY;2) Dept Developmental Biol, Stanford University, Stanford,CA.

Page 4: Cell Division and Growth Control 2 3 1 Moderator: Thomas Neufeld

28 PLATFORM SESSIONS

Program number is in bold above the title. The first author is the presenter. Abstracts begin on page 79.

Friday, March 31: 8:30 am–12:45 pmBallroom of the Americas D-F

Neural Physiology and Behavior

Moderator: J. Troy Littleton, Massachusetts Institute ofTechnology, Cambridge

32 - 8:30Memory trace in Drosophila DPM neurons. Dinghui Yu1, AlexC. Keene2, Anjana Srivatsan3, Scott Waddell2, Ronald L.Davis1,4. 1) Department of Molecular and Cellular Biology,Baylor College of Medicine, Houston, TX ; 2) Department ofNeurobiology, University of Massachusetts, Worcester, MA01605; 3) Department of Human and Molecular Genetics; 4)Department of Psychiatry and Behavioral Sciences, BaylorCollege of Medicine, Houston, TX 77030.

33 - 8:45Activity of the neurogenic protein NEURALIZED is requiredfor Learning and Long-Term Memory formation. EfthimiosSkoulakis, Elias Pavlopoulos. Institute of Molecular Biology& Genetics, BSRC Alexander Fleming, Vari, Greece.

34 - 9:00Discrimination learning changes the perception of odorintensity but not odor identity in Drosophila. Shouzhen Xia,Tim Tully. Cold Spring Harbor Laboratory, 1 Bungtown Road,Cold Spring Harbor, NY 11724.

35 - 9:15Neurofibromatosis type 1 is involved in both learning andmemory processes. Ivan S. Ho1, Frances Hannan2, InessaHakkar1, Yi Zhong1. 1) Zhong Lab, Cold Spring HarborLaboratory, Cold Spring Har, NY; 2) Department of CellBiology, New York Medical College, Valhalla, NY 10595.

36 - 9:30A Command Chemical Triggers an Innate Behavior bySequential Activation of Multiple Peptidergic Ensembles inthe CNS. Young-Joon Kim1, Dusan Zitnan2, C. GiovanniGalizia1, Kook-Ho Cho1, Michael Adams1. 1) Depts ofEntomology and Cell Biology & Neuroscience, University ofCalifornia, Riverside, CA; 2) Institute of Zoology, SlovakAcademy of Sciences, Bratislava, Slovakia.

37 - 9:45Reactive oxygen species-sensitive class IV multiple dendriticneurons coordinate larval growth and developmental timingof neuroendocrine signaling. Joshua A. Ainsley1, Myung-Jun Kim2, Lauren J. Wegman1, Janette M. Pettus1, WayneA. Johnson1,2. 1) Dept Physiology/Biophysics, Univ Iowa,Iowa City, IA; 2) Neuroscience PhD Program.

38 - 10:00gfA is a nicotinic acetylcholine receptor required for anescape behavior in Drosophila. Amir Fayyazuddin1, MahiraA. Zaheer1, P. Robin Hiesinger1, 2, Hugo J. Bellen1, 2. 1)Molecular and Human Genetics, Baylor College of Medicine,Houston, TX; 2) HHMI.

10:15 - Break

39 - 10:45Multimodal Sensory Integration in the Control of Rapid FlightManeuvers. John A. Bender, Michael H. Dickinson. Divisionof Biology, California Institute of Technology, Pasadena, CA91125.

40 - 11:00BiP expression levels affect recovery sleep in Drosophila.Nirinjini Naidoo, Vincent Casiano, John Zimmerman, AllanPack. Center for Sleep, University of Pennsylvania,Philadelphia, PA.

41 - 11:15Crossmodal integration of olfaction and taste. TakashiShiraiwa, Wynand Van der Goes van Naters, John Carlson.Department of Molecular, Cellular and Developmental Biology,Yale Univ., New Haven, CT.

42 - 11:30Drosophila Homer Is Required in Neurons of the EllipsoidBody and Pars Intercerebralis for Normal Ethanol Sensitivityand Tolerance. Nancy Urizar1, Zhiyong Yang1, HowardEdenberg2, Ronald Davis1,3. 1) Department of Molecular &Cellular Biology, Baylor College of Medicine, Houston, TX; 2)Center for Medical Genomics, Indiana University School ofMedicine, Indianapolis, Indiana, 46202; 3) Department ofPsychiatry and Behavioral Sciences, Baylor College ofMedicine, Houston, TX.

43 - 11:45Homeostatic transcriptional regulation of the slowpokechannel gene during drug tolerance modulates neuralexcitability. Alfredo Ghezzi, Jascha Pohl, Yazan Al-Hasan,Nigel Atkinson. Sect Neurobiology, Univ Texas, Austin, Austin,TX.

44 - 12:00fruitless is necessary for masculine patterns of aggressivebehavior and masculine territorial behavior. Steven Nilsen,Edward Kravitz. Dept Neurobiology, Harvard Medical School,Boston, MA.

45 - 12:15The Drosophila Bruchpilot protein is required for presynapticactive zone assembly and calcium-channel clustering toensure high vesicle release probability. Stephan Sigrist1,Erich Buchner2, Carolin Wichmann1, Manuela Schmidt1,Robert Kittel1. 1) European Neuroscience Institute Goettingen,Goettingen, Germany; 2) Lehrstuhl für Genetik undNeurobiologie, Am Hubland, Würzburg, Germany.

Page 5: Cell Division and Growth Control 2 3 1 Moderator: Thomas Neufeld

29PLATFORM SESSIONS

Program number is in bold above the title. The first author is the presenter. Abstracts begin on page 79.

Friday, March 31: 8:30 am–10:15 amBallroom of the Americas A-C

Signal Transduction

Moderator: Xinhua Lin, Children’s Hospital MedicalCenter, Cincinnati, OH

46 - 8:30Properties and components of the Drosophila BMP-signalingpathway. George Pyrowolakis1, Ute Nussbaumer1, AlexWeiss1, Kerstin Bartscherer2, Michael Boutros2, MarkusAffolter1. 1) Dept of Cell Biology, Biozentrum, University Basel,Basel, Switzerland; 2) Signaling and Functional Genomics,German Cancer Research Center, Heidelberg, Germany.

47 - 8:45Regulation of Wingless secretion and signaling by sprinter.Erica M. Selva1, Robyn Goodman1, Shreya Thombre1, DioneGray1, Zeynep Firtina1, Eric Spana2, Jamie Roebuck2,Norbert Perrimon3. 1) Biological Sciences, University ofDelaware, Newark, DE; 2) Model System Genomics, DukeUniversity, Durham, NC; 3) Department of Genetics, HarvardMedical School, Boston MA.

48 - 9:00Wnt and Hh Signaling and Polarity in the Drosophila Embryo.Nicholas Tolwinski, Jennifer Zallen. Developmental Biology,Sloan-Kettering Institute, New York, NY.

49 - 9:15Internalization is required for proper Wingless signaling inDrosophila. Elaine S. Seto1, Hugo J. Bellen1,2. 1) Program inDevelopmental Biology, Baylor College of Medicine, Houston,TX; 2) HHMI, Dept. of Molecular and Human Genetics, BaylorCollege of Medicine, Houston, TX.

50 - 9:30The role of Patched C terminal domain in Hedgehog signaling.Xingwu Lu, Thomas Kornberg. Dept Biochemistry, UnivCalifornia, San Francisco, San Francisco, CA.

51 - 9:45The novel SAM domain protein Aveugle is required for Rafactivation in the Drosophila EGF receptor signaling pathway.Jean-Yves Roignant1, Sophie Hamel2, Florence Janody3,Jessica Treisman1. 1) Skirball Institute of BiomolecularMedicine and Department of Cell Biology, New York UniversitySchool of Medicine; 2) Ecole Normale Supérieure, CNRSUMR8542, Par is, France; 3) Institut de Biologie duDéveloppement de Marseille, Campus de Luminy, Marseille,France.

52 - 10:00A Basolateral Junction Signaling Pathway Suppresses Normaland Tumor Invasion. Scott Goode1,2,4, Min Zhao1,4, PshemekSzafranski1,4, Matthew Anderson1,3,4, Chad Hall1,4. 1) Dept.Pathology; 2) Dept. of Molecular and Human Genetics,Molecular and Cellular Biology, and Program inDevelopmental Biology; 3) Dept. of Obstetrics and Gynecology;4) Baylor Col Medicine, Houston, TX.

Friday, March 31: 10:45 am–12:45 pmBallroom of the Americas A-C

Genome and Chromosome Structure

Moderator: Pamela Geyer, University of Iowa, Iowa City

53 - 10:45ARGONAUTE-1 accumulates locus specific long siRNArequired for building histone code of condensed chromatin.Utpal Bhadra1, S. N. C. V. Lakshmi Pushpavalli1,Krishnamohan Parsi2, Maheshwar Reddy1, Manika PalBhadra2. 1) Functional Genomics & Gene Silencing Group,Centre for Cellular & Molecular Biology, Hyderabad 500007,India; 2) Department of Chemical Biology, Indian Institute ofChemical Technology, Uppal Road, Hyderabad 500007, India.

54 - 11:00Regulation of transcription and chromatin structure byPoly(ADP-ribose) Polymerase. Alexei Tulin, Ammini Menon,Natalia Naumova. Basic Science, Fox Chase Cancer Center,Philadelphia, PA.

55 - 11:15Boundary swapping between Fab-8 and Fab-7 within thebithorax complex. Carole Iampietro, François Karch. Zoologyand Animal Biology, University of Geneva , Geneva, GE,Switzerland.

56 - 11:30Polycomb regulation in Drosophila: a genomewide view. YuriB. Schwartz, Tatyana G. Kahn, Vincenzo Pirrotta. Mol. Biol.and Biochem., Rutgers University, Piscataway, NJ.

57 - 11:45The JIL-1 histone H3S10 kinase regulates heterochromaticspreading and gene silencing in Drosophila. Huai Deng,Xiaomin Bao, Weiguo Zhang, Stephanie Lerach, Jack Girton,Jorgen Johansen, Kristen Johansen. Biochem, Biophys &Mol Biology, Iowa State University, Ames, IA.

58 - 12:00The putative Drosophila transcription factor Woc is requiredto prevent telomeric fusions. Giovanni Cenci1, Grazia D. Raffa2,

4, Giorgia Siriaco2, 5, Michael L. Goldberg3, Maurizio Gatti2. 1)DISTeBA, Univ Lecce-Ecotekne, Lecce, Italy; 2) Dipartimentodi Genetica e Biologia Molecolare and Istituto di Biologia ePatologia Molecolari del CNR, Universitá “La Sapienza”,00185 Rome, Italy; 3) Department of Molecular Biology andGenetics, Cornell University, Ithaca, NY 14853-2703; 4) TheScripps Research Institute 10550 North Torrey Pines RoadLa Jolla, CA 92037; 5) Molecular Cell and DevelopmentalBiology 309 Sinsheimer Labs University of California, SantaCruz Santa Cruz, CA 95064.

59 - 12:15Integration of different histone modification compartments inthe heterochromatic genes. Jiro C. Yasuhara, Kirk N. Okada,Barbara T. Wakimoto. Dept Biol, Univ Washington, Seattle,WA.

Page 6: Cell Division and Growth Control 2 3 1 Moderator: Thomas Neufeld

30 PLATFORM SESSIONS

Program number is in bold above the title. The first author is the presenter. Abstracts begin on page 79.

Friday, March 31: 10:45 am–12:45 pmLanier Grand Ballroom A-B

Drosophila Models of Human Diseases

Moderator: Mark Fortini, National Cancer Institute,Frederick, Maryland

60 - 10:45Dramatic CAG repeat instability in a Drosophila polyQ diseasemodel. Joonil Jung2, Nancy Bonini1, 2. 1) Howard HughesMedical Institute; 2) Department of Biology, University ofPennsylvania, Philadelphia, PA.

61 - 11:00Light-dependent Retinal Degeneration in trafficking mutantsof Drosophila. Yashodhan Chinchore, Patrick Dolph.Biological Sciences, Dartmouth College, Hanover, NH.

62 - 11:15Genetic Modifiers in Drosophila Reveal Common and DistinctMechanisms of Pathogenesis among Polyglutamine Diseases.Joana Branco1,2, Ismael Al-Ramahi1, Lubna Ukani1, AlmaPérez1, Pedro Fernandez-Funez1, Diego Rincón-Limas1,Juan Botas1. 1) Department of Molecular and Human Genetics,Baylor College of Medicine, One Baylor Plaza, Houston, TX,77030, USA; 2) Graduate Program in Basic and AppliedBiology, Abel Salazar Institute of Biomedical Sciences,University of Porto, 4099-003 Porto, Portugal.

63 - 11:30Drosophila NMNAT is required to maintain neuronal integrityand its overexpression protects from activity- and Ataxin-1-induced neurodegeneration. Rong Grace Zhai1, 2, Yu Cao2,Peter Robin Hiesinger1, 2, Yi Zhou1, 2, Sunil Q. Mehta3, KarenL. Schulze1, 2, Patrik Verstreken1, 2, 3, Hugo J. Bellen1, 2, 3, 4. 1)Howard Hughes Medical Institute, Baylor College of Medicine,Houston, TX; 2) Department of Molecular and HumanGenetics, Baylor College of Medicine, Houston, TX 77030; 3)Program in Developmental Biology, Baylor College ofMedicine, Houston, TX 77030; 4) Department of Neuroscience,Baylor College of Medicine, Houston, TX 77030.

64 - 11:45xbp1 splicing and Unfolded Protein Response is activated asa protective mechanism in the Drosophila model for theAutosomal Dominant Retinitis Pigmentosa. Hyung DonRyoo1,2, Pedro Domingos2, Hermann Steller2. 1) Cell Biology,NYU School of Medicine, New York, NY; 2) Steller Laboratory,The Rockefeller University, New York, NY.

65 - 12:00Pharmacological rescue of a Drosophila model for Fragile XSyndrome. Tom A. Jongens1, Sean M. J. McBride2, CatherineH. Choi3, Yan Wang1, David Liebelt2, Evan Braustein2, DavidFerreiro2, Amita Sehgal1, Kathleen K. Siwicki4, Thomas C.Dockendorff5, Hahn T. Nguyen2, Thomas V. McDonald2. 1)Genetics, 7096 Stellar-Chance, Univ Pennsylvania SchMedicine, Philadelphia, PA; 2) Albert Einstein College ofMedicine, Bronx, NY; 3) Drexel University College of Medicine,Philadelphia, PA; 4) Swarthmore College, Swarthmore, PA; 5)Miami University of Ohio, Oxford, OH.

66 - 12:15Dissecting muscular dystropy in Drosophila. HalynaShcherbata1, Andriy Yatsenko1,2, Karin Fischer1, MariyaKucherenko2, Uri Nudel3, David Baker1, Hannele Ruohola-Baker1. 1) Dept Biochemistry, Univ Washington, Seattle, WA;2) Ivan Franko Lviv National University, Lviv, Ukraine; 3) TheWeizmann Institute of Science, Rehovolt, Izrael.

67 - 12:30Drosophila homologs of FANCD2 and FANCL function in DNArepair. Lorri R. Marek, Allen E. Bale. Dept Genetics, Yale Univ,New Haven, CT.

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31PLATFORM SESSIONS

Program number is in bold above the title. The first author is the presenter. Abstracts begin on page 79.

Friday, March 31: 4:30 pm–6:30 pmBallroom of the Americas A-C

Physiology and Aging

Moderator: Scott Pletcher, Baylor College of Medicine,Houston, Texas

68 - 4:30Unraveling how diet restriction extends lifespan: stable isotopeanalysis of nutrient acquisition and allocation. Marc Tatar1,Kyung-Jin Min1, Diane O’Brien2. 1) Ecology and EvolutionaryBiol., Brown University, Providence, RI; 2) Institute of ArcticBiology, University of Alaska, Fairbanks, AK.

69 - 4:45Olfaction and food derived odorants regulate lifespan andmetabolism in D. melanogaster. Sergiy Libert1, ScottPletcher1,2,3. 1) CMB, Baylor College of Medicine, Houston,TX; 2) Huffington Center on Aging, Houston, TX; 3) Molecularand Human Genetics, BCM, Houston, TX.

70 - 5:00Fatty acid auxotrophy in Drosophila larvae lacking SREBP.Amit Kunte, Krista Matthews, Robert Rawson. Dept ofMolecular Genetics, University of Texas Southwestern MedicalCtr, Dallas, TX.

71 - 5:15Effects of aging on the maintenance of germline stem cellsand the stem cell niche. Chihunt Wong1, 2, Monica Boyle1,Michael Rocha1, D. Leanne Jones1. 1) Laboratory of Genetics,Salk Institute for Biological Studies, La Jolla, CA; 2) Departmentof Biological Sciences, University of California - San Diego,La Jolla, CA.

72 - 5:30The DHR96 nuclear receptor regulates xenobiotic responsesin Drosophila. Kirst King-Jones, Michael A. Horner, GeanetteLam, Carl S. Thummel. Howard Hughes Medical Institute,Department of Human Genetics, University of Utah, School ofMedicine, 15 N 2030 E Room 5100, Salt Lake City, UT 84112-5331, USA.

73 - 5:45Ras activity in the prothoracic gland regulates body size anddevelopmental rate via ecdysone release. Philip Caldwell,Magdalena Walkiewicz, Michael Stern. Department ofBiochemistry and Cell Biology, Rice University, Houston, TX.

74 - 6:00The regulation of lifespan by Falafel, a homolog to Suppressorof Map Kinase. Brian T. Sage1, Heinrich Jasper2, Li Qian3,Rolf Bodmer3, Andrew Dillin4, Marc Tatar1. 1) Dept Ecol &Evol Biol, Brown University, Providence, RI; 2) Dept of Biology,University of Rochester, Rochester, NY; 3) Burnham Institute,La Jolla, CA; 4) Salk Institute, La Jolla, CA.

75 - 6:15BMP signaling influences nutrient sensing and storage duringgrowth and development. Shannon Ballard, Kristi Wharton.Dept MCB, Brown Univ, Providence, RI.

Friday, March 31: 4:30 pm–6:30 pmBallroom of the Americas D-F

Organogenesis

Moderator: Deborah Jean Andrew, John HopkinsUniversity School of Medicine, Baltimore, Maryland

76 - 4:30The MARVEL domain protein, SINGLES BAR, is required forprogression past the pre-fusion complex stage of myoblastfusion. Beatriz Estrada1, Anne D. Maeland2, StephenGisselbrecht1, Nicholas H. Brown2, Alan M. Michelson1. 1)Division of Genetics, Department of Medicine, Brigham andWomen’s Hospital and Harvard Medical School, Boston, MA02115; 2) Gurdon Institute and Department of Anatomy,University of Cambridge, Cambridge, UK CB2 1QN.

77 - 4:45Actin remodeling is critical for myoblast fusion. Brian E.Richardson1, Karen L. Beckett1, Mary K. Baylies1,2. 1) AlliedProgram in Biochemistry, Molecular and Cell Biology, WeillGraduate School of Medical Sciences of Cornell University,New York, NY; 2) Developmental Biology Program, Sloan-Kettering Institute, New York, NY.

78 - 5:00WNT5 signaling acts through the atypical receptor, DERAILED,to guide salivary gland migration. Katherine E. Harris, StevenK. Beckendorf. Dept Molecular & Cell Biol, Univ California,Berkeley, CA.

79 - 5:15The adult Drosophila posterior midgut is maintained bypluripotent stem cells. Benjamin Ohlstein, Allan Spradling.Howard Hughes Medical Institute Research Laboratories,Depar tment of Embryology, Carnegie Institution ofWashington, 3520 San Martin Drive, Baltimore, Maryland21218 USA.

80 - 5:30Genetic dissection of epithelial maturation in trachea by liveimaging. Vasilios Tsarouhas, Kirsten-André Senti, SatishA. Jayaram, Johanna Hemphäla, Christos Samakovlis.Developmental Biology, Stockholm University, Stockholm,Sweden.

81 - 5:45Wurst, a novel Hsp70 interactor protein, is essential for trachealmorphogenesis. Matthias Behr1, Christian Wingen1, BirgitStümpges1, Verena Arndt1, Lara Kutschenko1, ChristianWolf2, Reinhard Schuh2, Michael Hoch1. 1) MolecularDevelopmental Biology, University Bonn; 2) MolecularDevelopmental Biology, Max-Planck-Institute Göttingen.

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82 - 6:00Gliotactin and Dlg form a unique complex at the tricellularjunction. Vanessa Auld, Kristi Charish, Jaimmie Que, SarahRavn, Joost Schulte. Dept Zoology, Univ British Columbia,Vancouver, BC, Canada.

83 - 6:15Rac function in epithelial tube morphogenesis. CarolynPirraglia, Rakhi Jattani, Monn Monn Myat. Department ofCell & Developmental Biology, Weill Medical College ofCornell University, New York, NY 10021.

Friday, March 31: 4:30 pm–6:30 pmLanier Grand Ballroom A-B

Gametogenesis and Sex Determination

Moderator: Richard Kelley, Baylor College of Medicine,Houston, Texas

84 - 4:30The eIF4G2 gene is required for meiotic division anddifferentiation in spermatogenesis. Catherine Baker,Margaret Fuller. Dept Developmental Biol, Stanford Univ SchMedicine, Stanford, CA.

85 - 4:45Notch signaling from the Germ Line Stem Cells induces StemCell Niche in Drosophila ovary. Ellen Ward, Steven Reynolds,Halyna Shcherbata, Steven Hatfield, Karin Fischer, HanneleRuohola-Baker. Department of Biochemistry, University ofWashington, Seattle, WA 98195.

86 - 5:00Sex-lethal feminizes neurons required for two female behaviorsby acting on gene targets other than transformer. Daniel S.Evans, Thomas W. Cline. Department of Molecular and CellBiology, University of California-Berkeley, Berkeley, CA. 94720-3204.

87 - 5:15Jagunal is required for polarized secretion during Drosophilaoogenesis. Sangil Lee, Lynn Cooley. Dept Genetics, Yale Univ,New Haven, CT.

88 - 5:30Novel Function of Tudor domains in Germline Developmentand Maintenance of Polar Granule Architecture. Alexey L.Arkov1, Ju-Yu S. Wang1, Andres Ramos2, Ruth Lehmann1. 1)Developmental Genetics Program, HHMI, Skirball Institute atNYU School of Medicine, New York, NY; 2) Molecular StructureDivision, National Institute for Medical Research, London.

89 - 5:45Opposing roles of the EGFR and Rho-type small monomericGTPases during niche formation. Cordula Schulz,Angshuman Sarkar, Nishita Parikh, Stephen Hearn. ColdSpring Harbor Laboratory, Cold Spring Harbor, NY.

90 - 6:00A nuclear hormone receptor that affects spermathecae numberand fertility. Anna E. Krueger1,2, Allan Spradling1,2. 1) CarnegieInstitution/HHMI, Baltimore, MD; 2) Johns Hopkins University,Baltimore, MD.

91 - 6:15Stonewalling germline stem cell differentiation throughepigenetic controls. Jean Z. Maines, Joseph K. Park, DennisM. McKearin. Molecular Biology, UT Southwestern MedicalCenter, Dallas, TX.

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Saturday, April 1: 8:30 am–10:30 amBallroom of the Americas A-C

Techniques and Genomics

Moderator: Rui Chen, Baylor College of Medicine,Houston, Texas

92 - 8:30Biological function of unannotated transcription during theearly development of D. melanogaster. J. Robert Manak, SujitDike, Victor Sementchenko, Philipp Kapranov, Jeff Long,Jill Cheng, Ian Bell, Srinka Ghosh, Antonio Piccolboni,Thomas R. Gingeras. AFFY Labs-Transcriptome, Affymetrix,Santa Clara, CA.

93 - 8:45Genome-wide Identification of Direct Targets of the DrosophilaRetinal Determination Protein Eyeless. Yumei Li, EdwardOstrin, Kristi Hoffman, Keqing Wang, Graeme Mardon, RuiChen. Department of Molecular and Human Genetics, BaylorCollege of Medicine, Houston, TX.

94 - 9:00Using Drosophila protein interaction maps to study geneticregulatory networks. Russell Finley1, Stephen Guest1, MariaCypher1, Kyle Gardenour1, Svetlana Pacifico1,2, BernardoMangiola1, Guozhen Liu1, Aleric Soans1, Huamei Zhang1. 1)Ctr Molecular Med & Gen, Wayne State Univ Med Sch, Detroit,MI; 2) Department of Computer Science, Wayne StateUniversity.

95 - 9:15Site-specific transgenesis using the phiC31 integrase.Johannes Bischof, Konrad Basler. Institute of MolecularBiology, NCCR Frontiers in Genetics, University of Zurich,Winterthurerstr. 190, CH-8057 Zurich, Switzerland.

96 - 9:30P[acman]: A Novel Drosophila Transgenesis Platform toFacilitate In Vivo Structural and Functional Studies of Genes.Koen Venken1, Hugo Bellen1,2. 1) Program in DevelopmentalBiology, Baylor College of Medicine, Houston, TX; 2) HHMI;Department of Molecular and Human Genetics; Baylor Collegeof Medicine, Houston, TX.

97 - 9:45Berkeley Drosophila Transcription Network Project: 3Dblastoderm gene expression atlas. David Knowles1, CrisLuengo Hendriks1, Soile Keränen1, Charless Fowlkes2,Gunther Weber3, Oliver Rübel4, Min-Yu Huang3, HanchuanPeng1, Angela DePace1, Lisa Simirenko1, Bernd Hamann3,Damir Sudar1, Jitendra Malik2, Mike Eisen1, Mark Biggin1. 1)Lawrence Berkeley National Laboratory; 2) UniversityCalifornia, Berkeley; 3) University California, Davis; 4)University Kaiserslautern, Germany.

98 - 10:00FlyExpress: An image-matching web-tool for finding geneswith overlapping patterns of expression in Drosophila embryos.Bernard Van Emden1, Hector Ramos1, SethuramanPanchanathan2, Stuart Newfeld3,1, Sudhir Kumar1,3, ArizonaState Univ, Tempe. 1) Biodesign Inst; 2) Department ofComputer Science and Engineering; 3) School of LifeSciences.

99 - 10:15BDGP Gene Disruption Project update. Robert W. Levis1,Yuchun He2,3, Joseph W. Carlson4, Martha Evans-Holm4, SooPark4, Kenneth H. Wan4, P. Robin Hiesinger2,3, Karen L.Schulze2,3, Roger A. Hoskins4, Allan C. Spradling1,3, Hugo J.Bellen2,3. 1) Dept Embryology, Carnegie Institution, Baltimore,MD; 2) Dept Molecular and Human Genetics, Baylor Collegeof Medicine, Houston, TX; 3) Howard Hughes Medical Institute;4) Dept Genome Biology, Lawrence Berkeley NationalLaboratory, Berkeley, CA.

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Saturday, April 1: 8:30 am–12:30 pmBallroom of the Americas D-F

Pattern Formation I

Moderator: Justin Kumar, Indiana University,Bloomington

100 - 8:30Gain of function screen identifies a factor promoting theformation of an ectopic notum. Nicole Grieder, Walter Gehring.Dept Cell Biology, Biozentrum, Basel, Switzerland.

101 - 8:45Matrix metalloproteinases: a role in imaginal disctransdetermination. Anne Sustar1, Ansgar Klebes2,3, TomKornberg2, Gerold Schubiger1. 1) Dept. Biology, Univ.Washington, Seattle, WA; 2) Inst. für Biologie-Genetik, FreieUniv. Berlin, Germany; 3) Dept Biochemistry, UCSF, SanFrancisco, CA.

102 - 9:00A structure-function analysis of Fat and Dachsous in growthcontrol, proximo-distal patterning and planar cell polarity. SethS. Blair, Hitoshi Matakatsu. Dept Zoology, Univ Wisconsin,Madison, WI.

103 - 9:15Additional sex combs affects antenna development via theregulation of Antp and Wg expression. Adi Salzberg1, NaomiHalachmi1, Karen Schulze2, Hugo Bellen2. 1) Department ofGenetics, Rappaport Faculty of Medicine, Technion, Haifa31096, Israel; 2) Department of Molecular and HumanGenetics, Baylor College of Medicine, Houston, TX 77030.

104 - 9:30Identification of early cell survival cues during eyedevelopment in Drosophila. Amit Singh1, Kwang-Wook Choi1,

2, 3. 1) Molecular & Cellular Biology, Baylor College of Medicine,Houston, TX 77030, USA; 2) Program in DevelopmentalBiology, Baylor College of Medicine, Houston, TX 77030, USA;3) Department of Ophthalmology, Baylor College of Medicine,Houston, TX 77030, USA.

105 - 9:45Dpp signaling regulates patterning and epithelial integrity inthe Drosophila retina. Julia B. Cordero, Ross L. Cagan. DeptMolec Biol & Pharmacology, Washington Univ, St Louis, StLouis, MO.

106 - 10:00 - Withdrawn

107 - 10:15Structure-functional analysis of Stardust protein in Drosophilaeye. Natalia A. Bulgakova, Oezlem Kempkens, ElisabethKnust. Institut of Genetics, Heinrich-Heine Universitaet,Duesseldorf, Germany.

10:30 - Break

108 - 11:00Computational identification of regulatory elements inDrosophila core promoters: Is there a “core promoter code”?David Sturgill1, Peter FitzGerald2, Andrey Shyakhtenko2,Brian Oliver1, Charles Vinson2. 1) LCDB, NIDDK/NIH,Bethesda, MD; 2) NCI/NIH, Bethesda, MD.

109 - 11:15Glorund, the elusive ovarian repressor of nanos translation.Yossi Kalifa, Tao Huang, Lynne N. Rosen, Seema Chatterjee,Elizabeth R. Gavis. Molecular Biology, Princeton University,Princeton, NJ.

110 - 11:30Regulation of eye specification by the Six family of transcriptionfactors. Justin Kumar, Brandon Weasner, Claire Salzer. DeptBiol, Indiana Univ, Bloomington, IN.

111 - 11:45Gene-Specific Transcriptional Repression by Wnt Signaling.Timothy Blauwkamp, Ming Fang, Mikyung Chang, JinheeChang, Jiong Li, Ken Cadigan. MCDB Dept, University ofMichigan, Ann Arbor, MI.

112 - 12:00Coordination of cell fate specification and cell division byubiquitin E3 ligase adaptor Phyllopod in sensory organprecursors. Hai-Wei Pi1, An-Chi Tien2, Pao-Ju Chang1, HugoBellen2. 1) Department of Life Science, Chang-GungUniversity, Kwei-Shan, Tao-Yuan 333, Taiwan; 2) Program inDevelopmental Biology, Baylor College of Medicine, OneBaylor Plaza, Huston, TX 77730, USA.

113 - 12:15Clonal tumor induction due to progenitor cell transformationin Drosophila. Frank Hirth, Heinrich Reichert, Bruno Bello.Biocenter/Pharmacenter, University of Basel, Switzerland.

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Saturday, April 1: 11:00 am–12:45 pmLanier Grand Ballroom A-B

Immune System and Cell Death

Moderator: Andreas Bergmann, University of Texas,M. D. Anderson Cancer Center, Houston

114 - 11:00Hormonal regulation of innate immunity in D. melanogaster.Thomas Flatt1, Ermelinda Porpiglia2, Subba R. Palli3, MarcTatar1, Neal Silverman4. 1) Department of Ecology andEvolutionary Biology, Brown University, Providence, RI; 2)University of Massachusetts Medical School, Worcester, MA;3) Department of Entomology, Agricultural Science Center,College of Agriculture, University of Kentucky, Lexington, KY;4) Division of Infectious Disease, Department of Medicine,University of Massachusetts Medical School, Worcester, MA.

115 - 11:15Wound-induced inflammation in Drosophila larvae involvesadhesive capture of hemocytes. Michael Galko1, Greg Fish2,Mark Krasnow2. 1) Dept. of Biochemistry and MolecularBiology, MD Anderson Cancer Center, Houston, TX; 2)Department of Dept. of Biochemistry/HHMI, Stanford University,Stanford, CA.

116 - 11:30The effector caspase drICE functions in developmental andirradiation-induced cell death in Drosophila. Dongbin Xu, YuanWang, Regina Willecke, Zhihong Chen, Tian Ding, AndreasBergmann. Cancer Ctr, Houston, TX; 2) The Genes andDevelopment Graduate Program, Univ Texas MD AndersonCancer Ctr, Houston, TX.

117 - 11:45Downregulation of diap1 confers competence for steroid-triggered cell death. Arash Bashirullah, Voot Yin, CarlThummel. HHMI, Department of Human Genetics, Universityof Utah, Salt Lake City, UT.

118 - 12:00Characterization of Drosophila Morgue function revises currentmodels of apoptosis regulation. Rebecca Hays. BiologicalSciences, Univ Kansas, Lawrence, KS.

119 - 12:15lola is required for proper chromatin structure and DNAcondensation during programmed cell death in oogenesis. B.Paige Bass, K. McCall. Biology Department, BostonUniversity, Boston, MA.

120 - 12:30Cytochrome-c-d regulates developmental apoptosis in theDrosophila retina. César Mendes1, Eli Arama1, SamaraBrown1, Heather Scherr2, Mayank Srivastava2, AndreasBergmann2, Hermann Steller1, Bertrand Mollereau1. 1)Howard Hughes Medical Institute, Strang Laboratory of CancerResearch, The Rockefeller University, New York, NY; 2) TheUniversity of Texas M.D. Anderson Cancer Center, Departmentof Biochemistry and Molecular Biology, Houston, TX.

Saturday, April 1: 4:00 pm–6:00 pmBallroom of the Americas A-C

Regulation of Gene Expression

Moderator: Scott Barolo, University of Michigan MedicalSchool, Ann Arbor

121 - 4:00Molecular basis of repressor recognition by Groucho. DavidIsh-Horowicz1, Barbara H. Jennings1, S. Mark Wainwright1,Laura M. Pickles2, S. Mark Roe2, Laurence H. Pearl2. 1)Developmental Genetics Laboratory, Cancer Research UK,London, UK; 2) Section of Structural Biology, Institute of CancerResearch, Chester Beatty Laboratories, London, UK.

122 - 4:15Squid, Cup, and polyA-binding protein cooperatively regulategurken mRNA expression. K. Nicole Clouse, Trudi Schüpbach.Howard Hughes Medical Institute, Department of MolecularBiology, Princeton University, Princeton, NJ 08544.

123 - 4:30Medea sumoylation restricts the range of the Dpp signal. WayneO. Miles1, Laurel A. Raftery2, Hilary L. Ashe1. 1) Faculty ofLife Sciences, The University of Manchester, Manchester,United Kingdom; 2) Cutaneous Biology Research Center,Massachusetts General Hospital and Harvard Medical School,Charlestown, MA.

124 - 4:45Dynamics of Heat Shock Factor at Native Gene Loci Examinedby Multiphoton Imaging of Drosophila Polytene Nuclei in LivingTissue. Jie Yao1, Katherine Munson2, Watt W. Webb1, John T.Lis2. 1) Applied and Engineering Physics, Cornell University,Ithaca, NY; 2) Molecular Biology and Genetics, CornellUniversity, Ithaca, NY.

125 - 5:00Genome Wide Mapping of The In Vivo DNA Binding Sites ofTranscriptional Regulators of the Pregastrula Gene Network.Xiao-Yong Li1, D. Nix1, S. MacArthur1, D. Pollard1, R.Bourghon2, V. Sementchenko3, T. R. Gingeras3, M. D. Biggin1,M. B. Eisen1. 1) Berkeley Drosophila Transcription NetworkProject, Lawrence Berkeley National Lab, Berkeley, CA; 2)Statistics Department, UC Berkeley, CA; 3) Affymetrix, Inc., CA.

126 - 5:15Solving the signal-regulated enhancer: a structure-functionapproach. Scott Barolo. Dept. of Cell & Developmental Biology,University of Michigan Medical School, Ann Arbor, MI.

127 - 5:30Polymerization of the Ets transcription factor Yan mediateschromatin spreading and repression in vivo. PavithraVivekanand, Ilaria Rebay. Univ Chicago, Chicago, IL.

128 - 5:45Non-cell autonomous tumor suppressor activity of the MVBsorting components Vps20, Vps28 and Snf7/Vps32. ThomasVaccari, David Bilder. Dept. of Molecular & Cell BiologyUniversity of California, Berkeley, Berkeley, CA.

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Saturday, April 1: 4:00 pm–6:00 pmBallroom of the Americas D-F

Pattern Formation II

Moderator: Christine Rushlow, New York University, NewYork

129 - 4:00non-coding RNAs are integral components of the Dorsal-Ventral patterning network in Drosophila. Fred Biemar1, JohnManak2, Mike Levine1. 1) Dept Molecular & Cell Biol, UnivCalifornia, Berkeley, Berkeley, CA; 2) Affymetrix, Santa Clara,CA.

130 - 4:15The Drosophila microRNA iab-4-5p has homeotic activity anddirectly represses Ultrabithorax. Eric Lai1, Matt Ronshaugen1,Joshua Hagen2, Mike Levine2. 1) Developmental Biology,Sloan Kettering Institute, New York, NY; 2) Dept. of Molecularand Cell Biology, UC Berkeley, Berkeley, CA.

131 - 4:30Echinoid mediates epithelial morphogenesis in the Drosophilaovary. Caroline Laplante, Laura A. Nilson. Dept Biol, McGillUniv, Montreal, PQ, Canada.

132 - 4:45Crag, a gene regulating epithelial organization andmorphogenesis. Natalie Denef1, 2, Yu Chen1, Trudi Schüpbach1,

2. 1) Molecular Biology, Princeton University, Princeton, NJ; 2)Howard Hughes Medical Institute.

133 - 5:00Hedgehog maintains odd skipped cell lineage duringDrosophila epidermis differentiation. Stephane Vincent, JeffAxelrod. Dept Pathology, Stanford Univ Sch Med, Stanford,CA.

134 - 5:15A 3D computational model for BMP dependent patterning ofthe Drosophila embryo based on positive feedback. David M.Umulis1, Mihaela Serpe2,3, Osamu Shimmi5, Wei-Shou Hu1,Hans Othmer4, Michael O’Connor2,3. 1) Chemical Engineeringand Materials Science; 2) Genetics, Cell Biology andDevelopment; 3) Howard Hughes Medical Institute; 4) Schoolof Mathematics and Digital Technology Center, University ofMinnesota, Minneapolis, MN; 5) Institute of Biotechnology,University of Helsinki, 00014 Helsinki, Finland.

135 - 5:30Complex Interactions Between D/V and A/P PatterningSystems Before Gastrulation Revealed by a 3-D Atlas of GeneExpression Patterns. Charless Fowlkes1, Cris LuengoHendriks2, Soile Keränen2, Angela DePace2, GuntherWeber3, Oliver Rübel4, Min-Yu Huang3, Lisa Simirenko3,Bernd Hamann3, Mike Eisen2, Damir Sudar2, DavidKnowles2, Mark Biggin2, Jitendra Malik1, BerkeleyDrosophila Transcription Network Project. 1) ComputerScience Division, UC Berkeley, Berkeley, CA; 2) Life SciencesDivision, LBNL, Berkeley, CA; 3) Institute for Data Analysisand Visualization, UC Davis, Davis, CA; 4) Computer ScienceDepartment, University of Kaiserslautern, Germany.

136 - 5:45Drosophila Pipe protein function in the ovary and theembryonic salivary gland. Xianjun Zhu1, Jonaki Sen2, LeslieStevens1, Jason Goltz1, David Stein1. 1) Section of MolecularCell & Developmental Biolohy and Institute for Cell andMolecular Biology, The University Texas at Austin, Austin, TX,USA; 2) Department of Molecular Gentics, Albert EinsteinCollege of Medicine, Bronx, NY 10461, USA.