GENERAL REACTIONS – overall pathway is exergonic

GLYCOLYSIS

Where:

cytoplasm

General:

Does not use O2

Energy from substrate

Most ancient of pathways

Overall pathway:

Glucose 2 pyruvate

net 2 ATP

2 NADH

CITRIC ACID CYCLE & e-TRANSPORT CHAIN

Where:

mitochondrium

General

Uses O2

Overall pathway:

Pyruvate 6CO2 + 6H2O

36 ATP

Produces large amounts of ATP with O2 acting as e- acceptor.

Occurs in the Mtiochondrium

1. Acetyl CoEnzyme A

EACH PYRUVATE GENERATES:

1 NADH

1 CO2 (RELEASED)

Coenzyme NAD+

+H

NADHCO2

ACETYL CoA

PYRUVATE

CoA

CoA

2 CO2

ATP

ADP +

P

2. Citric acid cycle/

Krebs Cycle

3 NAD+

3 NADH

FAD

FADH2

EACH PYRUVATE GENERATES:

3 NADH 1 FADH2

1 ATP 2 CO2

OXALOACETATECITRATE

3. ALL COMPOUNDS AT THE END OF THE KREBS CYCLE – THIS

IS FOR TWO PYRUVATES

CO2 ATP NADH FADH2

GLYCOLYSIS0 2

made directly

2 0

ACETYL Co-A

ACTIVATION2 0 2 0

KREB CYCLE4 2

Made directly

6 2

1

2

Fig. 6-11a

Space

betweenmembranes

Inner

mitochondrial

membrane

Electron

carrier

Protein

complex

Electron

flow

Matrix Electron transport chain ATP synthase

NADHNAD

FADH2 FAD

ATPADP

H2OO2

HHHH

H

H

H

H

H

H

H

HH

HH

HH

HH

H 2

P

SPECIFICSGENERATED ATP

per Glucose

(= 2 pyruvate)

1. GLYCOLYSIS 2 NADH 6 ATP

2 ATP (directly)

2. ACETYL CoA 2 NADH 6 ATP

3. KREBS 6 NADH 18 ATP

2 FADH2 4 ATP

2 ATP

3 ATP per NADH

2 ATP per FADH2