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Page 1: Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal
Page 2: Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal
Page 3: Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal

Cellular response to DNA damage

Reponse Mechanisms

Tolerance of DNA damage Replicative bypass of template damage

Translesion DNA synthesis

Reversal of DNA damage Enzymatic photoreactivation

Repair of O6-alkylguanine, O4-

alkyltimidine

Ligation of DNA strand breaks

Excision of DNA damage Base Excision Repair

Nucleotide Excision Repair

Mismatch Repair

Double strand breaks ligation Single strand annealing

Recombinational Repair

Non-Homologous End Joining

Page 4: Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal
Page 5: Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal
Page 6: Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal
Page 7: Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal

La radiazione Solare può essere distinta in 3 componenti principali a seconda della lunghezza d’onda:ULTRAVIOLETTO (100-400 nanometri) 10%VISIBILE ( 400-750nm.) 45%INFRAROSSO (750-3000nm.) 45%

Page 8: Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal

UV-induced damage

Page 9: Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal
Page 10: Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal

UV-responsive photolyases

Page 11: Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal

Direct reversal (de-alkylating proteins)

Page 12: Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal

Base Excision Repair

Page 13: Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal
Page 14: Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal
Page 15: Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal

Nucleotide Excision Repair

(E.coli)

Page 16: Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal
Page 17: Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal

Nucleotide Excision Repair (Global Genome Repair -Humans)

Page 18: Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal

Nucleotide Excision Repair(Transcription Coupled -Humans)

Page 19: Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal

Common features of GGR & TCR

Page 20: Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal

12.6 DNA Repair. DNA Repair Errors in DNA replication or damage to DNA create mutations Errors in DNA replication or damage to DNA create mutations -

Autophagy-Dependent Regulation of the DNA Damage …DNA Damage and Cellular Stress Responses Autophagy-Dependent Regulation of the DNA Damage Response Protein Ribonucleotide Reductase

DNA damage and repair lecture - University of North ... · DNA damage and repair ... Fanconi’s anemia - DNA repair. BRCA2 and 5 other genes ... Microsoft PowerPoint - DNA damage

Translesion DNA Synthesis Cells bypass lesions encountered at the replication fork during DNA synthesis and correct them after replication is finished

DNA DAMAGE AND REPAIR dna damage and repair - … 01. DNA damage and... · 2 dna damage and repair 1.1 single molecules and dna The information essential for life is stored and encoded

DNA Damage for Students

Dna damage and repair

Translesion DNA Polymerase eta functions in transcription

Translesion and Repair DNA Polymerases: Diverse Structure and … · synthesis (TLS) (11–13). DNA double-strand breaks (DSBs) are programmed and necessary for meiosis, immunoglob-ulin

Recombinase and translesion DNA polymerase decrease the ...microbiology.ucdavis.edu/kowalczykowski/PDF_files/Tan et al., 2015... · Recombinase and translesion DNA polymerase decrease

Satellite RNA Increases DNA Damage and Accelerates Tumor Formation … · DNA Damage and Repair Satellite RNA Increases DNA Damage and Accelerates Tumor Formation in Mouse Models

DNA Damage, DNA Repair, Aging, and Neurodegenerationperspectivesinmedicine.cshlp.org/content/5/10/a025130.full.pdf · DNA DAMAGE AND DNA REPAIR PATHWAYS Nucleic acids, proteins, and

DNA Damage, DNA Technologies, Genetics Since Gregor Mendel

DNA Damage Repair Mechanisms

Spermatogenesis, DNA damage and DNA repair mechanisms in

Regulation of translesion DNA synthesis: Posttranslational … · 2016-05-10 · DNA region, or via translesion synthesis (TLS), which employs specialized DNA polymerases to synthesize

DNA Damage-Dependent Acetylation and Ubiquitination of ...nmr.uhnres.utoronto.ca/ikura/publication/PDF Articles/2007/DNA Damage... · DNA Damage-Dependent Acetylation and Ubiquitination

Dna Damage Helle

Sphingosine, a Modulator of Human Translesion DNA Polymerase

DNA Damage Response_nature

DNA damage and DNA repair · DNA damage and DNA repair Spontaneous loss of bases Alkylation of bases Oxidation of bases UV-light induced damage: Cyclobutane dimers …

Developing Inhibitors of Translesion DNA Synthesis as

The critical mutagenic translesion DNA polymerase Rev1 is ...The critical mutagenic translesion DNA polymerase Rev1 is highly expressed during G 2M phase rather than S phase Lauren

DNA damage and repair lecture - unc.edu · DNA damage and repair ... Fanconi’s anemia - DNA repair. BRCA2 and 5 other genes ... Microsoft PowerPoint - DNA damage and repair lecture.ppt

Chromatin Responses to DNA Damage · * DNA repair * Checkpoint regulation * DNA replication Chromatin responses to DNA damage. Sensing DNA damage. Repairing DNA damage…

Spontaneous Damage to DNA. Examples of DNA Damage Induced by Radiation and Chemicals

Translesion DNA Synthesis and Mutagenesis in Prokaryotes · 2020. 4. 22. · Translesion DNA Synthesis and Mutagenesis in Prokaryotes Robert P. Fuchs and Shingo Fujii Cancer Research

DNA Damage and DNA Repair - University of North Carolina ... · Possible Consequences of DNA Damage DNA Damage Via UV, oxidation or methylation damage Mutation Cell Death Nothing

MUTAGENESIS DNA DAMAGE DNA REPAIR RECOMBINATION

Identifying Protein Interactions Amongst DNA Damage … · Identifying Protein Interactions Amongst DNA Damage ... Identifying Protein Interactions Amongst DNA Damage ... case of

DNA damage & Repair

Translesion-synthesis DNA polymerases participate in replication of

DNA Repair, Recombination Genome Instability · DNA Repair, Recombination Genome Instability Lichun Jiang, ... Source of DNA damage ... Consequence of DNA Damage DNA repair Cell cycle

Oxidative Damage of DNA

Gap-Directed Translesion DNA Synthesis of an … · Gap-Directed Translesion DNA Synthesis of an ... Igor Shevelev , Eleonora Orlando1,2, Helmut Pospiech , Juhani ... Shevelev I,