cellular responses. 1111 2222 3333 4444 5555 a 60-year-old man died secondary to a fungal infection...
TRANSCRIPT
Path JeopardyCellular Responses
Path is Lots O’ Fun
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Topic 1: 1 point• A 60-year-old man died
secondary to a fungal infection of the brain. An autopsy revealed the gross findings in the photograph. Necrosis of the brain is classified as
LIQUIFACTIVE NECROSIS
Topic 1: 2 points• A 30-year-old woman who had
leukemia was treated with bone marrow transplantation. She developed a skin rash that was interpreted as a sign of a graft-versus- host reaction. In the epidermis, there were scattered dead epidermal cells that had rounded contours and pyknotic nuclei. This form of cell death is caused by
activation of caspases through receptor transmitted signals
on the cell surface
Topic 1: 3 points• Uptake of bacteria into the
cytoplasm of neutrophilic leukocytes is called
PHAGOCYTOSIS
Topic 1: 4 points• A 28-year-old man was found to have
cirrhosis of the liver and pulmonary emphysema. The liver cells contained globular inclusions in their cytoplasm, which by electron microscopy are shown to be located inside the
Dilated cisterns of the rough endoplasmic
reticulum
Topic 1: 5 points
A 60-year-old obese man was admitted to the hospital for treatment of alcoholism. He has diabetes mellitus. A liver biopsy was performed, and the specimen showed that the liver cells contain increased amounts of
TRIGLYCERIDES
Topic 2: 1 point
This type of calcification occurs in patients who have hypercalcemia, which is most likely caused by secondary hyperparathyroidism
Metastatic calcification
Topic 2: 2 points
A 48-year-old woman has a malignant lymphoma. She is treated with a chemotherapeutic agent which results in the loss of individual neoplastic cells through fragmentation of cell nuclei and cytoplasm. The lymphoma decreases in size. The mechanism by which her neoplasm primarily responded was
Apoptosis
Topic 2: 3 points
A 53-year-old man has experienced severe chest pain for the past 6 hours. A coronary angiogram is performed and reveals >90% occlusion of the left anterior descending artery. What cellular change seen in irreversible injury will have occurred?
Nuclei undergo karyorrhexis
Topic 2: 4 points
A 30-year-old man is struck on the leg by a falling path book, which strikes him on his left leg in the region of his thigh. The skin is not broken. Within 2 days there is a 3 x 4 cm purple color at the site of injury. This substance most likely accumulated at the site of injury and produced a yellow-brown color 16 days later
Hemosiderin
Topic 2: 5 points
A 54-year-old man with a chronic cough has a squamous cell carcinoma diagnosed in his right lung. During surgery, the hilar lymph nodes are jet black in color. This pigment is the most likely cause for this appearance to the hilar nodes
Anthracotic pigment
Topic 3: 1 point
A 50-year-old woman with a history of unstable angina suffers an acute heart attack. Therapy to restore coronary blood flow is given. In spite of this therapy, the degree of myocardial fiber injury may increase because of this cellular abnormality
Increased free radicals
Topic 3: 2 pointsA 29-year-old man visited the sandy luxurious
beaches on Presque Isle State Park. The next day he has a darker complexion. His skin does not show warmth, redness, or tenderness. His skin tone fades to its original appearance within a month. This substance contributes the most to the biochemical process leading to these skin changes
Tyrosine
Topic 3: 3 points
A 55-year-old man has a 30-year history of poorly controlled diabetes mellitus. He has had extensive black discoloration of skin and soft tissue of his right foot, with areas of yellowish soft tissue, for the past 2 months. A below-the-knee amputation is performed. This type of necrosis is called
Gangrenous necrosis
Topic 3: 4 points
A 45-year-old man has a traumatic injury to his forearm and incurs extensive blood loss. On physical examination in the emergency department his blood pressure is 70/30 mm Hg. This cellular change is most likely to represent irreversible cellular injury
Nuclear pyknosis
Topic 3: 5 points• A 90-year-old woman dies from
pneumonia complicating Parkinson disease. At autopsy her heart is normal in size. On microscopic examination, there is increased lipochrome (lipofuscin) seen adjacent to the nuclei within the myocardial fibers. The cellular mechanism responsible for these findings is
Autophagocytosis
Topic 4: 1 pointThis is the first manifestation of
almost all forms of injury to cells
Cellular swelling
Topic 4: 2 points
These are the two principal forms of cell death
Necrosis and Apoptosis
Topic 4: 3 pointsThis is the result of denaturation of
intracellular proteins and enzymatic digestion of the lethally injured cell
Necrosis
Topic 4: 4 pointsThis is a special form of necrosis seen in
immune reactions involving blood vessels
Fibrinoid Necrosis
Topic 4: 5 points
A 38-year-old man has a health screening examination. He has a routine chest x-ray that shows a 2 cm nodule in the right lower lobe. The nodule shows caseous necrosis and calcification. The following process explains the appearance of the calcium deposition
Dystrophic calcification