central metabolism cofactor biosynthesis · ppp9 pi h h2o ppi h h2o h2o dad-5 h[p] atp adp h pi h2o...
TRANSCRIPT
Inorganic Ion Transport
2
2
2
Ubiquinol
thiL
2
5
Cofactor Biosynthesis
Riboflavin
Molybdenum Synthesis
3
Heme Biosynthesis
4
Lipoate
dead end
2
NAD/NADP Metabolism
Fe-S clusters
ATPSynthase
3
2
CoA
33
dead end
Biotin
Enterochelin
Converted to GLX
8
Vitamin B12
Transhydrogenase
2
Thiamin
2
(see Central Metabolism Map)Menaquinone
methionine synthase
Vitamin B6
2 2
Folate2
33
Isoprenoid
atp
lipoate[e]
adocbip
h[p]
h[p]
h
adp
adp
pi
h2o
pydam
g3p
h
gbbtn[p]
adp
10fthf
h
h
nmn[p]
h[p]
dad-5
h
etoh
nadh
co2
adp
amet
2dhp
dhnpt
atp
rdmbzi
atp
h
nh4
lac-L[e]
ppi
nadph
h
h[p]
o2
nad
h
h
amet
h
adp
pi
dxyl
sufse
crnDcoa
glyclt
h
gtp
h2o2
4fe4s
atp
ahdt
ppi
pi
nadh
atp
6pgc
h2o
nadh
h2o
for
pheme[p]
thmnp
pi
pppi
cys-L
4adcho
adp
mql8
h2o
atp
fe3
ni2
lipopb
pi
iscssh
h2o
h2o
h
ppi
co2
atp
amp
atp
na1
5drib
h2o
23dhb
h
co2
h
h
nadp
g3p
adp
bmoco1gdp
sufbcd
nadph
h
pi
pydxn[p]
bglycogen
bbtcoa
coa
mn2[p]
4hthr
fum[e]
thf
fmnh2
mg2
h
pi
btn[e]
ala-L
h
nadh
h
hcys-L
atp
coa
h2o
glc-D[p]
h
pmeACP
fe2
co2
ppi
mobd[p]
h[p]
ppi
h
h
pyr
pi
nad
h2o
adp
5apru
akg
6hmhptpp
fru[e]
h2o
adp
12ppd-R
h
dhpmp
h2o
for
h
h
h
octa
dhpt
amp
h
atp
h
ac[p]h
pan4p
fe2
ctp
nadp
pi
h
h
na1[p]
nadp
h[p]
for
nadp
h2o
nad
ppi
gcald
ppi
atp
nh4
h[p]
h
h
adp
pi
mptamp
octapb
bwco1gdp
adp
ppi
nadp
fadh2
h2o
nad
adpglc
atp
q8h2
accoa
h
h2o
ichor
4r5au
h
q8
h
dmbzid
co2
pi
co2
nadp
3pg
nadh
co2
atp
h2o
glyclt[p]
co2
glu-L
h
h2[p]
gmp
cmp
h2o
pyr
ade
cobalt2[p]
pi
2tpr3dpcoa
nad
ppi
nadh
adp
cu2
atp
atp
asp-L
k[p]
h2o
h
fum
fe2
h
succ
h
h
h2o
dhgly
xyl-D
h
for
h2o
h2o
pi
h
nad
h
mobd[e]
f6p[p]
nadph
h[p]
h2o
gtp
h2o
h2o
ppi
5mthf
pi
nadp
nac
h[p]
co2
pyr[e]
pi
akg
pi
g1p[e]
h
co2
h2o
adp
ribflv
tyr-L
ahcys
atp
atp
4mhetz
atp
acald
ctbt[p]
h
pydxn
h
h
2dmmql8
atp
g6p
h
h[p]
amet
h2o
ACP
co2
atp
o2
h
atp
frdp
lac-D[p]
adp
pi
iscssh
cpmp
14dhncoa
nad
h
h
pi
pyr
ppi
for[e]
h
crn[e]
glutrna
h
h
h
h
h
adp
h
h
cu2
glyc[e]
h
ppi
mg2[p]
fum
h2o
pi
h2o
nh4
pi[p]
co2
pi
iscssh
h2o
glu-L
cph4
g6p[p]
h
adp
h[p]
atp
prpp
h2o
fadh2
h
ppi
mlthf
h2o
h
h
mg2[e]
r5p
cu2
iscu
fad
atp
h
ala-L
ipdp
nadph
h2o
coa
h2o
2me4p
h
h
adp
opmeACP
gbbtn
lipoate[p]
cobalt2
h
h
pi
moco
h
cpppg3
2oph
h2o
fe2
pi
pdx5p
nad
h
atp
nadph
nadp
sufbcd-2fe2s2
h
coa
2dmmq8
atp
pih2o
gtp
5aop
pi
nadh
h[p]
h
5prdmbz
crn-D
iscu
2fe1s
nadh
mqn8
ncam
na1
crn-D
co2[p]
h
adocbi
nadp
atp
h
nicrnt
ppi
h
h
ppi
nadph
co2
pi
h2o
2sephchc
2mecdp
amp
atp
cbl1[e]
h2o
adp
co2
sufbcd
ppi
cit[p]
nadh
adprib
atp
cu2[e]
h2o
nad
adp
nadp
ppi
h2o
q8h2
nad
2pg
bwco
23ddhb
pi
h
co2
h2o
mpt
atp
cl[p]
nad
h2o
adp
h2o
adp
pi
pi
co2
5fthf
nmn[e]
agdpcbi
h[p]
fe2
iscs
h
nh4
h
2omhmbl
h
cdg
ahcys
h[p]
pnto-R
h2o
adp
q8
cl
pep
adp
coa
akg
h[p]
ahcys
adp
glyc3p[e]
nad
co2
nadp
coa
pi[p]
2fe2s
amet
sufsesh
2fe2s
amp
23dhba
h
h
h[p]
nad
atp
f1p
h2o
dhap
nmn
nadh
h2o
adp
nad
co2
fadh2
h
acald
ppi
o2
h2o
h2o
acon-T
adp
h
h[p]
nadp
nadp
mal-L[e]
pi
ni2[e]
h2o2
nadh
h2o
h2o
h
h2o
mql8
pep
pi
iscu-2fe2s2
pi
h
pi
cu2
ppi
h2o
atp
h
h
h
h
ocACP
glu-L
h2o
adp
g6p[e]
pyr
meoh[e]
h2o
rib-D[e]
h2o
co2
amet
atp
nadh
h
nad
h
gtp
h
ppi
lac-D[e]
mobd
adp
for
nad
co2
h
atp
btn[p]
nadph
glyc
dmpp
h
h
fadh2
f6p
bwcogdp
nad
h
amp
h[p]
h[p]
h2o2
pyr
dhf
h ppi
pydam[p]
nadph
h2oppi
pppi
amp
adp
h
ppi
pi
lipoamp
h
nad
h
adp
amp
h[p]
ctp
h2o
h
h2o
h
icit
h[p]
h2o
pi
atp
nad
cbi[p]
amp
h
ppi
mn2[e]
2fe2s
atp
acald[e]
pydx
pi
amet
h
nh4
lac-D
ac
fe2
h2o
oaa
atp
h
h[p]
h
bmoco
h
4hbz
h[p]
ppi
2ohph
h
fadh2
fe2
h2o
nadph
5aprbu
quln
h
atp
ade
h2o
2dmmql8
ala-B[p]
preq0
mql8
iscu-2fe2s
sufse
h
adp
coa
h2o
o2
cu[e]
malACP
nadh
6hmhpt
ogmeACP
pi
thmmp
nadh
atp
h
h
akg[p]
h
nad
adp
ppi
fad
sufbcd-2fe2s
atp
atp
h
acon-C
h
nadh
moadcoo
k[e]
nadh
cu
pydx5p
ru5p-D
glu1sa
mthgxl
nadph
2fe1s
thm
h[p]
h
adocbl[e]
for
ppi
glyc3p
cbl1[p]
h2o
lald-D
adp
btn
ahcys
h
nad
h
nadh
ca2
ala-D
pyr
adp
h
nad
amp
ac[e]
h
h2o
h
atp
nh4
h2o
h[p]
nadph
h
succ
nadph
uppg3
tungs
h
cbi
h
h2o
nadph
h
nicrnt
pi
co2
h2o
coa
nad
h
h
flxr
atp
h[p]
nadp
pi
h2o
nad
atp
h
co2
nad
h2o[p]
ppi
udcpdp
h[p]
nadph
h
fadh2
wco
akg[e]
s17bp glu-L
o2
iscssh
atp
hgmeACP
h
pi
4crsol
h2o
nadp
fad
co2
h
atp
pap
pi
ppbng
adp
ppi
o2
na1[p]
glyclt[e]
amp
lac-L[p]
adp
adp
h
h2o
amet
h2o
fadh2
accoa
pnto-R[e]
h[p]
h
ctp
lac-L
sufbcd
o2[p]
h
h
h[p]
nadp
nadh
adp
zn2
succ[e]
dmlz
h2o
nadh
h
pi
succ[p]
h
pheme[e]
amp
nadh
h
h
h
adp
h
na1[p]
4ampm
h2o
nadh
h
h
adp
aconm
h[p]
fe2
nadh
for[p]
h
tungs[e]
thmpp
ca2[e]
nadph
nh4
13dpg
nadp
h2o
pi
h2[e]
moadamp
h
h
xyl-D[e]
thm[e]
moadcosh
h
dtbt
nadh
h
crn
adp
na1
fru[p]
atp
mptamp
mqn8
nh4
mal-L[p]
atp
pi
meoh
dhmpt h
ahcys
dhna
h
h
iscs
h2o
adp
ACP
adp
adp
atp
glyc3p[p]
h
h
5drib
ppi
4fe4s
atp
atp
h
o2
h2o
nh4
pi
amp
air
atp
h2o
adp
amp
iscu
h
atp
h2o
h[p]
atp
h
cl[e]
pep
h
23dhbzs
h
fum[p]
amp
iscs
enter
h
pyr
pep
pheme
atp
nad
coa
h
atp
pi
h
adp
nad
12ppd-R[p]
h
ru5p-D
h
atp
nad
h[p]
nadh
s7p
h
etoh[p]
chor
h[p]
nadph
ni2[p]
ala-L
ppi
gtp
prpp
3ophb
amob
h
pyr
nadh
nadh
pydx[e]
sucbz
amp
lgt-S
cbi[e]
gbbtn[e]
h2o
h
btnso
nadph
h
pyr
pyr
gtp
amet
h
e4p
h2o2
atp
pyr
sbzcoa
atp
2mahmp
h
sufbcd-4fe4s
atp
apoACP
cys-L
bmocogdp
mql8
malcoa
3mob
h
8aonn
ctbtcoa
atp
nad
nad
h2o
atp
pi[p]
h[p]
ohpb
dhmptp
h
h[p]h2o
coa
ppi
actp
nadh
nadp
ACP
adp
nadp
atp
no
h2o
sufbcd
h2o
adp
atp
nadp
h
h
scl
pi
pih2o
crn-D[e]
h
4ppcys
dxyl5p
xyl-D[p]
dnad
h
h
nadph
pi
adp
h
fad
atp
adp
h
nadh
adp
pnto-R[p]
na1[e]
gtp
h
iscu-4fe4s
atp
fdp
ACP
pi
2ommbl
h
h
h
h
h
amet
2fe1s
h2o
pep
dhap
coa
fe3
ser-L
q8
gln-L
h
sheme
h
atp
h
pydam[e]
h
h2
ppi
h
4c2me
amp
h
adp
n2o
meoh[p]
co2
h
succ
fmn
h
h2o
ala-B
h
h[p]
h2o
ppp9
pi
h
h2o
ppi
h
h2o
h2o
dad-5
h[p]
atp
adp
h
pi
h2o
succoa
lipoate
atp
glx
2p4c2me
xu5p-D
h2o
cbl1
ppi
h[e]
h2o
h
dad-5
gthrd
asp-L
pi[p]
nac
mocogdp
4mpetz
h2o
octdp
egmeACP
atp
pydxn[e]
dha
ahcys
gly
adocbl
nad
pi
mql8
h[p]
h
dpcoa
seramp
trnaglu
iasp
iscs
pi
nad
h
adp
pi
amet
nadp
o2
zn2[p]
fad
cu2
h ppi
pi
h2o2
2shchc
sufsesh
dscl
co2[e]etoh[e]
h
glycogen
f6p[e]
nad
co2
cu2
pppi
h
25drapp
o2
pyr
atp
q8
6pgl
h2o
atp
iscu
4abz
pimACP
met-L
adp
h
r5p
4per
h
2omph
pyam5p
dann
dxyl5p
nadp
cu2[p]
succ
hmbil
grdp
h[p]
ppi
h2o
h
adp
nadph
adp
nadp
r5p
coa
h[p]ca2[p]
gmeACP
ac
dad-5
ala-B[e]
h
mqn8
tungs[p]
q8h2
mlthf
nad
atp
3fe4s
adocbl[p]
h2o
epmeACP
succ[p]
h
h
nadp
nadh
h
preq1
h
12ppd-R[e]
mn2
h
2ddg6p
ala-L
hemeO
nadh
h[p]
cobalt2[e]
cmp
adp
h
coa
h
zn2[e]
h2o[p]
mococdp
glyc[p]
nadp
nadph
atp
ahcys
g1p[p]
met-L
cit
nadh
h2o
nad
h
h
adp
pi
e4p
amp
athtp
q8h2
pi
h
hpmeACP
met-L
fad
db4p
h
crn[p]
h
h
nadph
atp
amet
adp
glc-D[e]
pi
ade
adp
h2o
methf
h[p]
k
h
amet
nadh
coa
ppi
gtp
fad
pi
nadh
h2o
pi
ppi
nadph
h2o
adp
rbflvrd
h
adp
atp
phthr
h
mal-L
co2
pyr[p]
glc-D
cu[p]
acald[p]
co2
4ppan
h2o
h
pi
pi
pi
pi
flxso
nadh
h2o
crn-D[p]
nadph
atp
adp
pydx[p]
nadp
malcoame
xylu-D
h
thm[p]
atp
atp
adp
fum
h
pi
atp
4ahmmp
pant-R
h
h
h2o
h
malACP
h2o
h2o
g1p
pppg9
atp
h
co2
atp
thf
nadph
nadph
h
adp
cit[e]
h2o
h[p]
atp
met-L
rib-D
mqn8
crn-D[p]
coa
rib-D[p]
atp
2ombzl
atp
ppi
h
h
for
crncoa
h
h
h2mb4p
nad
atp
q8h2
h
h2o
atp
ctbt
GLCtex
ADOCBLtonex
L-LACD2
MECDPDH5
BMOGDS2
XYLK
MALt2_3pp
OPMEACPS
CPH4S
G6PP
DHFS
H2tex
OCTNLL
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CUtex
FADRx
MTHFD
NADS1
CRNDCAL2
GLCP
RPE
ICHORS
MN2tpp
G6Pt6_2pp
AOXSr2
PPCDC
OPHHX3
OPHBDC
2MAHMP
OGMEACPD
CTBTCAL2
12PPDRtpp
NADN
4HTHRS
FBA
NADK
CLt3_2pp
AKGDH
EGMEACPR
EPMEACPR
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SHCHCS3
ACKr
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PYDXtpp
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I2FE2SR
MG2uabcpp
PPCK
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NAtex
DHNCOAT
OPMEACPR
ASPO5
MOHMT
CPMPS
I2FE2SS2
GLYC3Ptex
PTAr
BSORy
CBL1abcpp12PPDRtex
G3PD2
DHBSH
ADCS
I4FE4SR
TPRDCOAS
TUNGStex
MTHFR2
ALDD2x
OHPBAT
I2FE2SS
CITt3pp
NI2tex
FCLT
CRNCBCT
OMMBLHX3
ASP1DC
CUt3
CTBTt2rpp
PNTK
OMBZLM
SERASr
IPDPS
HEMEOS
ThDPAT
ALATA_D2
TKT2
MALt2_2pp
MG2tex
ACALD
RZ5PP
GLBRAN2
NMNN
GCALDD
FESD1s
GTPCII2
LALDO2x
DHBD
AMMQLT8
PYK
PYDXNK
AKGt2rpp
MOGDS
G6PDH2r
FHL
ACPS1
GLCptspp
IPDDI
CBLAT
ACALDtex
PYDAMtpp
ZN2t3pp
CRNDtex
MPTS
HMPK1
TALA
DXYLK
FRD3
FORtex
ASPO6
CTBTabcpp
PGK
CU1abcpp
PANTS
NADTRHD
S4FE4ST
MNtex
CITtex
DHPS2
CHRPL
MN2t3pp
L-LACtex
NAt3pp
NMNAT
ETOHtrpp
CBItonex
NNAM
ICHORSi
ADOCBLS
CRNCAR
Kt3pp
CPPPGO
THMabcpp
XYLI1
MG2t3_2pp
D-LACtex
S2FE2SR
FMNRx2
UPP3S
ALCD2x
PYRt2rpp
ZN2abcpp
DHPPDA2
PYDAMK
PERD
DM_5DRIB
GLGC
MPTSS
DNTPPA
CAt6pp
GLCS1
BWCOGDS1
CRNCDH
NAt3_2pp
EDDGLYCtpp
AMAOTr
FRUKFBP
LIPOS
FTHFLi
Kt2pp
CRNtex
XYLtex
TMPK
ASPO4
RIBabcppENTCS
BSORx
SUCBZL
RBK
DMATT
THMtex
LIPOCT
GBBTNtex
PYDXPP
DHAPT
FUMt2_3pp
MALtex
CU2abcpp
FUMt2_2pp
DHMPTR
NNDMBRT
SHCHF
BWCOGDS2
PGM
AMPMS2
GLYC3Pt6pp
G1Ptex
ICYSDS
BMOGDS1
PDX5PO2
PPC
PDX5PS
5DOAN
CRNt7pp
SUCCt3pp
BMOCOS
UPPDC1
FMNRx
LGTHL
SUCCtex
I4FE4ST
OGMEACPS
BALAtex
CRNBTCT
NAt3_1p5pp
CRNCAL2
LIPOtex
MOX
MEOHtex
MECDPS
BWCOS
PPPGO3
ACONTa
GTPCI
CLtex
CITt7pp
DHPTPE
ICL
CCGS
EDA
RBFSb
Zn2tex
ALATA_L2
NNATr
CRNt8pp
NNDPR
CRNt2rpp
D-LACt2pp
COBALT2abcpp
XYLabcpp
CA2t3pp
PYDXK
PYDXtex
DM_4CRSOL
GLYCLTtex
NADPPPS
FRUpts2pp
DPR
I2FE2ST
MOCDS
GLYC3Pabcpp
MGSA
MDH3
G1SAT
OPMEACPD
TUNGSabcpp
SUCCt2_2pp
GLYCLTt4pp
MOBDtex
PYDXNtex
PTPATi
PGL
OMMBLHX
FESD2s
APRAUR
CA2tex
TYRL
MTHFC
THFAT
PGMT
BTS5
ACONMT
MPTAT
HMBS
COBALT2tpp
PDH
GND
AKGtex
GLCt2pp
G3PT
CBIAT
G1PPpp
ICDHyr
TMK
MALCOAMT
SEPHCHCS
CS
PHEMEtiex
PMPK
MDH
CU1Opp
PPPGO
ENO
Ktex
TDP
CU2tex
TKT1
PPNCL2
PGI
GLYK
MOADSUx
PNTOt4pp
ACALDtpp
ZNabcpp
OPHHX
H2tpp
DNMPPA
ASPO3
RBFSa
DHNPTE
NMNtex
GRTT
FRUtex
ZN2tpp
HPPK2
L-LACt2rpp
NI2tpp
SCYSDS
CDGS
NMNDA
FUMtex
DMQMT
ATPS4rpp
PHEMEabcpp
HETZK
ALDD2y
PMEACPE
L-LACD3
F6Pt6_2pp
SUCBZS
NMNt7pp
PFK
CU2tpp
CITL
NAMNPP
S2FE2SS
PYDAMtex
PDXPP
RPIRIBtex
COBALT2t3pp
MOCOS
LIPATPT
FUM
MDH2
THD2pp
CDGR
FRD2
G6Ptex
RBFK
S2FE2ST
QULNS
GLYCLTt2rpp
HYPOE
GAPD
GLDBRAN2
DXPRIi
MOBDabcpp
ETOHtex
TMPPP
CDPMEK
BTNt2ipp
5DOAN
ACONIs
CBL1tonex
DHNCOAS
SUCOAS
CRNabcpp
PYDXNtpp
PDX5POi
NI2t3pp
ACS
NMNPtpp
WCOS
OHPHM
PMDPHT
ICHORT
TPI
GLYCtex
FTHFD
BALAt2pp
DMPPS
ACt2rpp
ME1
FLVR
PYAM5PO
GLYOX
OMPHHX
SHCHD2
S4FE4SR
SUCDi
PPBNGS
FMNAT
MEOHtrpp
GLUTRR
THZPSN3
PPS
NI2uabcpp
PFL
GLYCDx
Central Metabolism
Figure S4