central nervous system depressants. antipsychotic agents “typical” – derivatives of...
TRANSCRIPT
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Central Nervous System Depressants
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ANTIPSYCHOTIC AGENTS
“Typical” – derivatives of phenotiazine, tioxanten, butyrophenon – they cause disorders of extrapyramidal system function – syndrome of parkinsonism
“Atypical” – derivatives of indole, benzodiazepine – they cause those negative reactions very rarely
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Aminazine (chlorpromazine)
• 1951 – aminazine was introduced into clinical practice
• It brought considerable changes into situations of psychiatric clinics
• Before appearance of aminazine for treatment of psychologically sick patients insulin or electric shock were widely used, in some cases - lobotomy
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Phenothiazine derivatives
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Thioxanten derivatevesThioxanten derivateves
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Butyrophenon derivativesButyrophenon derivatives
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piperasine-dibenzodiazepine derivatives(Clozapin, Clozapine, FazaClo, Leponex, Zaponex, Clopin
Eco.)
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Mechanism of action of neuroleptics
Influence on dopamine (D2), noradrenergic,
serotoninergic, GABA-ergic, cholinergic receptors
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Properties of neuroleptics
• Antipsychotic action - they eliminate productive symptoms of psychosis (delirium and hallucinations), affective disorders
• They eliminate psychomotor excitation
• consciousness is present
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1 Lung Cancer, 2 Criminality, 3 Stroke, 4 Breast Cancer, 5 Same Sex Attraction, 6 Leukemia, 7 Malformation, 8 Alzheimer’s, 9 Ulcerative
Colitis, 10 Rheumatoid Arthritis, 11 Alcoholism, 12 Schizophrenia, 13 Depression, 14 Suicide attempt,
15 Diabetes type I, 16 Divorce, 17 Crohn’s disease, 18 Asthma, 19 Hypertension, 20 Co twin is best friend, 21 Diabetes type II, 22 Autism,
23 Opposite Sex Attraction, 24 Phenylketonuria
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Administration of antipsychotic action of neuroleptics
Treatment of psychosis• Schizophrenia
• Maniac-depressive psychosis
• Alcohol psychosis
• Reactive psychosis
In a case of psychomotor excitationof various etiology
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Delirium tremens – alcohol psychosis
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Influence of neuroleptics on psychical activity
1. Drugs with psychosedative action – they cause condition of psychomotor indifference (apathy, decreasing of moving activity, retarded emotions and wishes, disappearance of initiative)
Aminazine, clozapine (leponex), chlorprotyxen, haloperidol, droperidol
Peculiarities of usage: psychosis with manifestations of excitation
Contraindications: psychosis with retardness, inertia, depression, stupor, apatho-abulic syndrome
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Neuroleptics with psychosedative action
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Influence of neuroleptics on psychical activity
2. Drugs which stimulate psychical activity (increase mimics and liveliness, increase moving activity, improve the mood)
Triftazin, ethaperazin, moditen, majeptil Peculiarities of usage: psychosis with psychomotor retardness, apatho-
abulic conditions, stupor conditions Contraindications: affective disturbances,
mania, psychomotor excitation
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Drugs which stimulate psychical activity
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Other properties and indications for administration of neuroleptics
• Drugs with psychosedative action – for potentiation of action of hypnotic drugs, opioid and nonopioid analgesics, drugs for general anesthesia, local anesthetics, for example, neuroleptanalgesia
• Anti-emetic action (elimination of vomiting of central origin): brain tumors, radial and chemical therapy, intestinal impassability, intoxication with heart glycosides, apomorphine and other drugs
• Decreasing of body temperature (only in the case of simultaneous hypothermia)
• Decreasing of blood pressure (alpha-adrenoblocking properties – aminazine, droperidol) – in case of hypertensive crisis, lungs, brain edema
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Side effects of neuroleptics• Extrapyramidal disorders: muscular hypertonus, general
constraint, tremor of hands, tongue, mandible, head, seizure contractions of muscles, vegetative crisis
For treatment – cyclodol (levodopa is contraindicated because it diminishes therapeutic effect of neuroleptics)
• Orthostatic collapse• Complicated nose breathing, hypostatic, aspirate pneumonia• Dyspeptic disorders: anorexia, changes of taste• Abdominal pain• Constipation• Damage of the liver (cholestasis)• Granulocytopenia (especially clozapin)• Hyperglycemia, dysmenorrhea, galactorrhea, hyperthyrosis,
gynecomastia, impotence• Aminazine has a considerable irritative action
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syndrome of parkinsonism
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Parkinsone syndrome treatment
Cyclodolum Levodopa is contraindicated
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TRANQUILIZERS• Agonists of benzodiazepine receptors:
- derivatives of benzodiazepine – chlozepid, sybazon, phenazepam, gidazepam
• Agonists of serotonine receptors: buspyrone• Drugs with other mechanisms of action:
- derivatives of diphenilmethan: amisyl
- derivatives of propanediole: meprotan
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TRANQUILIZERS
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Properties of tranquilizers
• Anxiolytic properties – eliminate feeling of anxiety, restlessness, fear, aggressiveness, irritability, cause peace, careness, decreasing of moving activity
• Hypnotic (somnolent) action
• Myorelaxing action (of central genesis)
• Antiseizure action
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Administration of tranquilizers
Anxiolytic action• Treatment of neurosis, accompanied by fear, anxiety,
exertion, increased irritability, insomnia• In case of headache and heart pain of neurotic origin,
so called organic neurosis• In case of abstinence in alcohol and drugs addicts• In case of diencephalons crisis (sybazon)
Tranquilizers do not diminish productive symptoms of psychosis!
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Administration of tranquilizers
Anti-seizure and myorelaxing action (depression of CNS structures, braking polysynaptic spinal
reflexes)
sybazon, fenazepam• In a case of seizures of any etiology (epileptic status,
tetanus, poisoning with seizure causing poisons) sibazon is introduced intravenously (intramuscularly) – 2-4 ml of 0,5 % solution repeatedly (maximum daily dose – 14 ml)
• To eliminate muscle tension in a case of radiculitis, arthritis, myositis, bursitis
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Seizures(tetanus)
drug of a first choice -
Sibazon
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SIDE EFFECT OF TRANQUILIZERS• Psychological and physical addiction
Prophylaxis:
1. Duration of treatment course should not be more than 2 months
2. Repeated course – not earlier than after 3 weeks break
• Sleepiness, reeling walk, retarded reactions tranquilizers should not be administered in ambulatories to people whose
professions are connected with quick reactions
• Paradox reaction of excitation, insomnia• Dizziness, decreasing of libido, disturbances of
menstrual cycle • Uncontrolled urination, defecation, ataxia,
dysarthria • Acute poisoning in case of overdosing
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FLUMAZENIL (ANEXAT) ANTAGONIST OF TRANQUILIZERS
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Combination of tranquilizers with alcohol-containing drinks is absolutely
contraindicated(pathological alcohol
intoxication)
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Valeriana
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PASSIFLORA
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Leonurus L. dog nettle
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ADMINISTRATION OF
SEDATIVE DRUGS
• Neurosis
• Neurasthenia
• Hysteria
• Increased irritability
• Insomnia
• Primary stages of essential hypertension
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Bromism
• Cause – accumulation of bromide ions in organism in case of their prolonged administration as a result of material accumulation
• Symptoms: rhinitis, cough, conjunctivitis, skin rash, general weakness, memory disorders
• Treatment: sodium chloride (10-20 g / day), a lot of drinking (3-5 l / day), regular and frequent cleaning of skin and digestive tract
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Hypnotic agents
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CNS Depressants
Hypnotics
• Calm or soothe the CNS to the point that they cause sleep
Sedative-Hypnotics—dose dependent:• At low doses, calm or soothe the CNS
without inducing sleep• At high doses, calm or soothe the CNS• to the point of causing sleep
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Epilepsy
• In the U.S., 2.5 million people are affected.
• Not all seizure disorders are epilepsy.
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Epilepsy
SeizureAbnormal electrical discharges in the cerebral cortex caused by sudden, excessive firing of neurons
– Result in a change in behavior of which the patient is not aware
– While conscious, the patient may or may not lose movement control
– Loss of body control may affect one area or the entire body
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Anticonvulsants
• lamotrigine (Lamictal)
• levetiracetam (Keppra)
• lorazepam (Ativan)
• oxcarbazepine (Trileptal)
• phenobarbital (Luminal Sodium)
• phenytoin (Dilantin)
• primidone (Mysoline)
• topiramate (Topamax)
• valproic acid (Depakene)
• zonisamide (Zonegran)
Drug List
• carbamazepine (Epitol, Tegretol)
• clonazepam (Klonopin)• diazepam (Valium)• divalproex (Depakote)• ethosuximide (Zarontin)• Fosphyenytoin (Cerebyx) • gabapentin (Neurontin)
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valproic acid (Depakene) and divalproex (Depakote)
• Increases the availability of GABA (inhibitory)
• Take with water, not a carbonated drink
• Do not use aspirin
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Dispensing Issues
• Depakote and Depakene can easily be confused.
• Be careful with Depakote and Depakote ER.
• Depakote ER is only once a day.
Warning!
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Parkinson’s Disease
Physiology• Normal muscle movement requires balance of
dopamine (inhibitor) and ACh (stimulator)• In the substantia nigra, enough dopamine is
released to counteract the effects of ACh• In parkinsonism, enough dopamine is not released
which leads to excessive motor nerve stimulation
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Substantia Nigra
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Parkinson’s Disease
Drug Therapy• Improves the functional ability and clinical
status of patients• Aims at symptomatic relief, does not alter
the disease process• Patients may have temporary or prolonged
remission• Side effects can be a problem
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