Accredited Body: DQS GmbH, August-Schanz-Straße 21, 60433 Frankfurt am Main 1 / 12

CERTIFICATE

This is to certify that

Merck KGaA

Frankfurter Straße 250 64293 Darmstadt Germany with the organizational units/sites as listed in the annex

has implemented and maintains an Environmental Management System.

Scope: Development, production and distribution of pharmaceuticals, chemical products and analytical systems

Through an audit, documented in a report, it was verified that the management system fulfills the requirements of the following standard:

ISO 14001 : 2004 + Cor 1 : 2009

Certificate registration no.

Valid from

Valid until

Date of certification

005356 UM

2015-12-17

2018-09-14

2015-12-07

DQS GmbH

Götz Blechschmidt Managing Director

Annex to Certificate Registration No. 005356 UM

Merck KGaA

Frankfurter Straße 250 64293 Darmstadt Germany

This annex (edition: 2015-12-07) is only valid in connection with the above-mentioned certificate. 2 / 12

Location Scope

005356 Merck KGaA Frankfurter Straße 250 64293 Darmstadt Germany

Development, production and distribution of pharmaceuticals, chemical products and analytical systems

450238 Merck KGaA & Co. Werk Spittal Hösslgasse 20 9800 Spittal an der Drau Austria

Production and distribution of pharmaceuticals.

450237 Merck S.A. Estrada dos Bandeirantes, 1099 22710-571 Rio de Janeiro - RJ Brazil

Production and distribution of pharmaceuticals and chemical products.

450240 Merck Serono SA Zone Industrielle de l´Ouriettaz 1170 Aubonne Switzerland

Production and distribution of pharmaceuticals.

450325 Merck Serono SA Zone Industrielle B 1809 Fenil-sur-Corsier Switzerland

Development and production of pharmaceuticals.

450241 Merck & Cie KG Weisshausmatte 6460 Altdorf Switzerland

Production of chemical products.

Annex to Certificate Registration No. 005356 UM

Merck KGaA

Frankfurter Straße 250 64293 Darmstadt Germany

This annex (edition: 2015-12-07) is only valid in connection with the above-mentioned certificate. 3 / 12

Location Scope

450324 Merck & Cie KG Im Laternenacker 5 8200 Schaffhausen Switzerland

Development and production of chemical products.

496582 Merck S.A. Francisco de Paula Taforó 1981 -Ñuñoa 7780349 Santiago Chile

Manufacture and distribution of pharmaceutical products and micronutrient mixtures. Distribution of chemical products and pharmaceutical ingredients, instruments and laboratory equipment. Service of installation, maintenance, repair and technical assist of instruments and equipment of laboratory.

504300 Beijing Skywing Technology Co., Ltd No. 11, Baifuquan Road Changping Science Park Beijing 102200 P. R. China

R&D, production and service of cell culture media & the design, manufacture and service of mechanical stirred-tank bioreactor for animal cell cultivation.

514696 Merck Display Materials (Shanghai) Ltd. First Floor and Second Floor Area B of 14th Building East Side and 15th building, No. 211 Qinqiao Road, Shanghai 201206 P. R. China

Design, development, manufacture and distribution of liquid crystal materials; distribution of other chemical materials

518298 Merck Electronic Materials (Suzhou) Limited No. 70, Longpu Road, Industrial Park 215021 Suzhou City, Jiangsu Province P. R. China

Production and sale of photoresist products, edge bead rinse thinner and remover used for electronic industry. Distribution of ancillary chemicals and additives used for electronic industry, including anti-reflective coating, developer and adhesion promoter.

Annex to Certificate Registration No. 005356 UM

Merck KGaA

Frankfurter Straße 250 64293 Darmstadt Germany

This annex (edition: 2015-12-07) is only valid in connection with the above-mentioned certificate. 4 / 12

Location Scope

467000 Litec-LLL GmbH Siemensallee 1 Gebäude 67 17489 Greifswald Germany

Development and production of phosphors.

240237 Merck KGaA Mainzer Straße 41 64579 Gernsheim Germany

Development, production and distribution of chemical products and analytical systems.

518299 Merck Performance Materials GmbH Rheingaustraße 190 - 196 65203 Wiesbaden Germany

Design and development, production and supply of photo resists, liquid crystals and process chemicals for the electronic and printing industry.

002955 Merck Schuchardt OHG Eduard-Buchner-Straße 14-20 85662 Hohenbrunn Germany

Production and distribution of chemical products.

450321 Merck S.L.U. Polígono Merck, Junto a la Carretera Nacional N-152 08100 Mollet del Valles Barcelona Spain

Production and distribution of pharmaceuticals and chemical products.

426638 Merck S.L.U. Polígono Industrial Tres Cantos Calle de Batanes No 1 28760 Tres Cantos (Madrid) Spain

Development and production of pharmaceuticals.

Annex to Certificate Registration No. 005356 UM

Merck KGaA

Frankfurter Straße 250 64293 Darmstadt Germany

This annex (edition: 2015-12-07) is only valid in connection with the above-mentioned certificate. 5 / 12

Location Scope

450274 Merck Serono Biodevelopment S.A.S. 1, rue Nicolas Brémontier Site des Montesquieu 33650 Martillac France

Development and production of biological molecules for therapeutic use.

478742 Merck Santé S.A.S. Le Pressoir Vert 45402 Semoy France

Development and production of pharmaceuticals.

518302 Merck Performance Materials SAS Usine de Lamotte – 1 Rue du Flottage 60350 Trosly Breuil France

Design, production and sale of colloidal silica.

450275 Merck Santé S.A.S. 5, rue Clément Ader 62100 Calais France

Production of chemical products.

492648 Millipore S.A.S. 39 Route Industrielle de la Hardt 67120 Molsheim France

Design, development, production engineering, manufacturing and distribution of devices, media and equipments for fluid analysis and purification. Production engineering, manufacturing and distribution of water purification systems for laboratories. Design, installation, commissioning and sale of filtration equipments. Validation and scientific support to users. Maintenance and repair for biomonitoring equipments. Technical & Commercial Support to customers.

Annex to Certificate Registration No. 005356 UM

Merck KGaA

Frankfurter Straße 250 64293 Darmstadt Germany

This annex (edition: 2015-12-07) is only valid in connection with the above-mentioned certificate. 6 / 12

Location Scope

450276 Merck Santé S.A.S. 10 Av. de Lattre de Tassigny 69330 Meyzieu France

Production of chemical products and distribution of pharmaceuticals.

505626 Millipore (UK) Ltd. 2 Fleming Road Kirkton Campus Livingston EH54 7BN Great Britain

Development, manufacture and sale of clinical diagnostic products derived from biological sources products and cell culture media and reagents.

506586 Merck Chemicals Ltd. Boulevard Industrial Park, Padge Road Beeston Nottingham NG9 2JR Great Britain

Sales, storage and distribution of commercial chemicals, pigments, bioscience products and cell culture media.

450286 P.T. Merck Tbk. Jl. TB. Simatupang no. 8 Pasar Rebo Jakarta Timur 13760 Indonesia

Development, production and distribution of pharmaceuticals and chemical products.

426641 Merck Ltd. Plot 11/1 Marwasodo Usgaon Ponda Goa 403 407 India

Development and production of pharmaceuticals and chemical products.

Annex to Certificate Registration No. 005356 UM

Merck KGaA

Frankfurter Straße 250 64293 Darmstadt Germany

This annex (edition: 2015-12-07) is only valid in connection with the above-mentioned certificate. 7 / 12

Location Scope

518300 Merck Performance Materials Pvt. Ltd. Survey No 109, 110, 112 Savroli Village, Taluka Khalapur, Dist. Raigad Maharashtra 410 203 India

Design, development, manufacturing, marketing and sales of silicon resins (polysilazanes and silazanes) and formulations.

501956 Merck Life Science Private Limited 50 A & 51, 2nd Phase, Ring Road, Peenya Bangalore 560 058 India

Manufacturing of filtration equipment and related products for Biopharm, Process Solutions, BioMonitoring, LabWater, Bioscience, Laboratory Testing, Validation and Compliance Services.

505619 Merck Millipore Ltd. Tullagreen Carrigtwohill T45 KD29 County Cork Ireland

Manufacture of filtration products for the pharmaceutical, food, beverage, electronic and analytical industries. Manufacture of chromatography adsorbents, immobilized enzymes and other ligands for modification and purification of biomolecules.

450291 Inter-Lab Ltd. Hakishon St. No. 18 Yavneh 81101 81220 Israel

Development and distribution of pharmaceuticals.

450296 Merck Serono S.p.A. Via Luigi Einaudi 11 12 Guidonia Montecelio Italy

Development and production of pharmaceuticals.

450311 Merck Serono S.p.A. Viale della Magnolie 15, Z.I. 70026 Modugno Italy

Production of pharmaceuticals.

Annex to Certificate Registration No. 005356 UM

Merck KGaA

Frankfurter Straße 250 64293 Darmstadt Germany

This annex (edition: 2015-12-07) is only valid in connection with the above-mentioned certificate. 8 / 12

Location Scope

453292 Merck Ltd. Arco Tower 5F 8-1 Shimomeguro 1-chome Meguro-ku Tokyo 153-8927 Tokyo Japan With the departments Performance Materials Liquid Crystals Performance Materials Pigments & Cosmetics, Operations Technical Support, Bioscience/ Merck Millipore Human Resources/ Procurement/ Administration

Sales of chemical products. Bioscience Global Technical & Sales Support Organization.

497390 Merck Ltd. Yokohama Technical Center YBP West Tower 2F, 134 Godo-cho, Hodogaya-ku 240-0005 Yokohama-shi, Kanagawa-ken Japan With units Provantage Lab, Process Solutions, Merck Millipore

Laboratory testing, validation and compliance services.

497387 Merck Ltd. Performance Materials Liquid Crystals, Operations Atsugi Site 4084, Nakatsu, Aikawa-machi, Aikou-gun 243-0303 Kanagawa-ken Japan With the departments Performance Materials Liquid Crystals Operations

Design, development and manufacture of chemical products.

Annex to Certificate Registration No. 005356 UM

Merck KGaA

Frankfurter Straße 250 64293 Darmstadt Germany

This annex (edition: 2015-12-07) is only valid in connection with the above-mentioned certificate. 9 / 12

Location Scope

497388 Merck Ltd. Nippon Express Baraki Air Cargo Center 2526-26 Baraki Ichikawa-shi 272-0004 Chiba-ken Japan

Stock holding and provision of repair for filtration products and analytical instrumentation.

518301 Merck Performance Materials Manufacturing G.K 3330 Chihama 437-1412 Kakegawa-shi, Shizuoka Japan

Development and production of photoresists for ICs and LCDs, other electronics materials-related chemical products (developer, thinner, rinse, remover, antireflective coating, adhesion promoter, insulating coating, protecting coating and electronic raw materials), functional coating.

453297 Merck Ltd. Senba Central Building 3F, 6-8 Hon-machi 2-chome, Chuo-ku 541-0053 Osaka Japan

Distribution of pharmaceuticals, chemical products and analytical systems.

426640 Merck Ltd. Onahama Site 51-15 Aza Egoshi, Kurosuno Izumi-machi, Iwaki-shi 971-8184 Fukushima-ken Japan

Development and manufacture of chemical products.

518304 Merck Electronic Materials Ltd. 50-14 Hyupdongdanji-gil, Miyang-myeon Anseong-si, Gyeongki-do 17600 Republic of Korea

Research, development, production, inspection and testing of light-sensitive materials and related processing chemicals for semiconductor industry

Annex to Certificate Registration No. 005356 UM

Merck KGaA

Frankfurter Straße 250 64293 Darmstadt Germany

This annex (edition: 2015-12-07) is only valid in connection with the above-mentioned certificate. 10 / 12

Location Scope

505622 Merck Performance Materials Ltd. 306, Pyeongtaekhang-Ro, Poseung-eup Pyeongtaek-shi, Gyeonggi-do 17956 Republic of Korea

Development, production and distribution of pharmaceuticals and chemical products.

507107 Merck S.A. de C.V. Calle 5 No. 7 col. Ind. Alce Blanco 53370 Nuacalpan de Juarez; Estado de Mexico Mexico

Production and distribution of pharmaceuticals.

450233 Merck Pharmaceuticals (Pvt.) Ltd. F - 126, Sind Industrial Trading Estate Karachi-75730 Pakistan

Production and distribution of pharmaceuticals.

450312 Merck (Pvt.) Ltd. 7, Jail Road Quetta-87300 Pakistan

Production and distribution of pharmaceuticals.

506584 Merck Inc. 24/F Floor GT Tower International, 6813 Ayala Avenue 1227 Makati City, Metro Manila Philippines

Marketing, sales and distribution of pharmaceutical drugs, chemical products, and laboratory supplies and equipment.

518305 Merck Performance Materials Co., Ltd. No. 458-6, 8 & 11 Sinsing Rd., 303 Hu Kou Township Hsinchu Country Taiwan

Development and manufacture of photo-resist products and top-layer anti-reflective coating materials.

Annex to Certificate Registration No. 005356 UM

Merck KGaA

Frankfurter Straße 250 64293 Darmstadt Germany

This annex (edition: 2015-12-07) is only valid in connection with the above-mentioned certificate. 11 / 12

Location Scope

426643 Merck Display Technologies Ltd. No. 39, 39-1, Ching Chien 1st Road Kuan Yin Industrial Park 328 Taoyuan Taiwan

Development, production and distribution of chemical.

496587 EMD Millipore Corp. EMD - Living Innovation 17 Cherry Hill Drive Danvers, MA 01923 United States of America

Design and development of membrane, membrane filtration devices, and laboratory research instrumentation. Manufacture of disposable Bio processing assemblies. Bioscience Global Technical & Sales Support Organization.

518306 EMD Performance Materials Corp. BRANCHBURG 70 Meister Avenue Somerville, NJ 08876 United States of America

The Design and manufacture of photoresist and related chemical products.

450330 EMD Performance Materials Corp. 110 EMD Blvd. Savannah, GA 31407 United States of America

Design and development, manufacture and distribution of pigments.

496589 EMD Millipore Corp. 195 W. Birch Street Kankakee, IL 60901 United States of America

Design, development, manufacturing and distribution of Highly Purified Blood Proteins and Biologically Active Factors.

505630 EMD Millipore Corp. 6 Research Park Saint Charles, MO 63304 United States of America

Design and development, manufacture, technical support and distribution of research use only immunoassay kits. Bioscience Global Technical & Sales Support Organization.

Annex to Certificate Registration No. 005356 UM

Merck KGaA

Frankfurter Straße 250 64293 Darmstadt Germany

This annex (edition: 2015-12-07) is only valid in connection with the above-mentioned certificate. 12 / 12

Location Scope

505631 EMD Millipore Corp. 28820 Single Oak Drive Temecula, CA 92590 United States of America

Design and development, manufacture and distribution of research kits and chemicals.

478744 EMD Serono Research & Development Institute, Inc. 45A Middlesex Turnpike, Bedford Campus Billerica, MA 01821 United States of America

Development and production of pharmaceuticals.

492647 EMD Millipore Corp. 11 Prescott Road Jaffrey, NH 03452 United States of America

Manufacture, storage and distribution of membranes, purification systems and filtration products for bioprocess, healthcare and beverage industries.

505606 EMD Millipore Corp. 2828 Highland Avenue Norwood, OH 45212 United States of America

Development, production and distribution of chemical products.