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  • 7/25/2019 CG182 NICE Guidance 20150309

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    CF= =CF= =M =GG = I@HG:M =GG = I@HG:GGGGH HGGGGH H

    C@==@ I=@=

    I@=G: 23 $I@M 2014

    =.F.I/I=/182

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015

    http://nice.org.uk/guidance/cg182http://nice.org.uk/guidance/cg182
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    CHHGCHHG

    #HFIH= .......................................................................................................................................................................... 4

    =M D=GG #FJ= !@@ IHG ! HF=G ...................................................................................... 5

    =M D=GG #FJ= !@@ IHG AC HF=G ..................................................................................... 5

    DFI FH=G................................................................................................................................................................. 7

    H=H-HF F.......................................................................................................................................................... 8

    M F=F=H=G F =@HH=................................................................................................................................ 9

    #JGH=H=G F F= =M =GG ............................................................................................................................. 9

    C@GG=TH= F= =M =GG ................................................................................................................................. 10

    @ 1 C@GG=TH= F= =M =GG IG= ! AC HF=G................................................... 11

    FIM =HF=............................................................................................................................................................... 12

    @ 2 FIM =HF= ! (IF H=G F MF, M ! AC HFM) F

    @ K=H, F H F=G , CD .................................................................................................................................................... 13

    1 H=G ..........................................................................................................................................................15

    FG IG = H=G I=@= ......................................................................................................................................................... 15

    1.1 #JGH=H=G F F= =M =GG ....................................................................................................................... 16

    1.2 C@GG=TH= F= =M =GG .......................................................................................................................... 21

    1.3 FIM =HF= ....................................................................................................................................................... 23

    1.4 #FH= IH= ................................................................................................................................................... 27

    1.5 FF@ F=HF= ......................................................................................................................................................................... 29

    1.6 FHFM..................................................................................................................................................................... 30

    1.7 HF @=H=G ................................................................................................................................................................ 33

    2 #@HH=: HH= GHFH ...............................................................................................................................35

    2.1 C@I@H= GH=HG FH==-G @FI@F T@HFH= FH (!) .................................................... 35

    2.2 G= MGHH= C-G GH=HG ! ....................................................................................................................... 36

    2.3 C@GG=M= F= =M =GG .................................................................................................................................... 37

    2.4 IFHF FGIFG..................................................................................................................................................................... 38

    3 GF FH=G .......................................................................................................................................39

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 2 %f 62

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    3.1 @-H...................................................................................................................................................................... 39

    3.2 AH=@H@H HFM ................................................................................................................................................................ 39

    3.3 =R=HG=R@GHF GMGH ........................................................................................................................ 40

    3.4 F= =-@KF= HG...................................................................................................................................................... 40

    3.5 =H= D GI@HG = H H CDR=F@ =GFFG ....................................... 40

    4 HF =FH=...........................................................................................................................................................42

    4.1 K H=G I=@= KG J@................................................................................................................ 42

    4.2 @H #CE I=........................................................................................................................................................... 42

    5 !I=@= DJ@H !FI, H=@ C@@FH= CHF #CE FH H..........45

    5.1 !I=@= DJ@H !FI ........................................................................................................................................... 45

    5.2 H=@ C@==@ !I=@= CHF ................................................................................................................................... 46

    5.3 #CE FH H.................................................................................................................................................................... 46

    CG HF I@=H=................................................................................................................................................48

    AIH H=G I=@= ...........................................................................................................................................................49

    H =FH=......................................................................................................................................................................... 49

    HFH FH=G.................................................................................................................................................... 60

    HF JFG=G H=G I=@= ................................................................................................................................................. 61

    #@HH= ................................................................................................................................................................................ 61

    IF FGG==@=HM........................................................................................................................................................................... 61

    CMF=H............................................................................................................................................................................................. 62

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 3 %f 62

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    =G I=@= F@G C!73.

    =G I=@= =G H G=G 5.

    #HFIH=#HFIH=

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    F= H K HM KF F==@@M I@=G (G IH H=G I=@= F H=@G).

    CF= =M =GG (CD) GF=G F@ =M IH= /F GHFIHIF. #H =G ,

    FIH@M IF=G H L=GHG HHF K=H HF =H=G (GI G F=JGI@F=GG =HG). FH H GJF CD =G @G GG=H K=H =FG F=G HF

    G==TH JFG IHG GI G IH =M =IFM, @@G, F=@HM FH@=HM. F=G

    J@= CD =FGG K=H . AG =M MGIH= FFGGG, G L=GH= =H=G

    F =FG = GJF=HM. CD FFGG H -GH =M =GG =

    G@@ IH G==TH FH @.

    CD =G IGI@@M GMHH=, IH =H =G HH@, HGHG F CD F G=@ F@M J=@@.

    F =G J= HH HFHH FJH F @M H FFGG= CD, FI F FJH

    H J@H @=H=G, FI H F=G F=JGI@F =GG. "KJF, CD =G

    H IF=G IG HF F G=T GMHG, =H =G H H =G F

    =G H J GH.

    @GG=TH= CD G J@J JF H=. # 2004, H DFHH "@H'G H=@

    GFJ= FKF F F@ GFJ=G H H 2002 H=@ =M IH= =M

    D=GG IHG I@=HM #=H=H=J @GG=TH= CD. =G @GG=TH= =J=G CD =H 5

    GHG IGG H =H= =L =M IH=, H @FI@F T@HFH= FH (!),

    FFG =M H T H GHG. HG 3R5 KF T M ! @GG H

    60 @/=/1.73 2

    K=H F K=HIH FFG =M , H @GH 2 GFH G=G

    GFH M F= H @GH 90 MG. HG 1 2 KF T M H FG FFG

    =M =@I= @I=IF=, IF= G=H F@=H=G, @HF@MH HF

    F@=H=G IG M HII@F =GFFG, F@=H=G HH M =GH@M, GHFIHIF@

    F@=H=G HH M == =GHFM =M HFG@HH=.

    @=H =FG F=G JFG IHG, H 2008 #CE I=@= F= =M

    =GG GIGH 2 M G H H=G @GG=TH=: H GI=J=G= GH 3 =H 3 (!

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 4 %f 62

    http://www.nice.org.uk/guidance/cg182/chapter/about-this-guidelinehttps://www.gov.uk/government/publications/national-service-framework-kidney-diseasehttps://www.gov.uk/government/publications/national-service-framework-kidney-diseasehttp://www.kidney.org/professionals/kdoqi/http://www.kidney.org/professionals/kdoqi/http://www.kidney.org/professionals/kdoqi/http://www.kidney.org/professionals/kdoqi/https://www.gov.uk/government/publications/national-service-framework-kidney-diseasehttps://www.gov.uk/government/publications/national-service-framework-kidney-diseasehttp://www.nice.org.uk/guidance/cg182/chapter/about-this-guideline
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    45R59 @/=/1.73 2) 3 (30R44 @/=/1.73

    2), H =H= H GITL '' H H

    G==TH FH=IF= H M GH. 2008 #CE I=@= T G==TH FH=IF= G

    IF=FM @I=:FH== FH= (AC) 30 /@ F =F (FI@M I=J@H H

    FH=:FH== FH= 50 /@ F =F). # 2013, H =M D=GG: #FJ= !@@

    IHG (D#!) I= H J@IH= H F= =M =GG

    H H GI=J=G= ! HF=G GIGH M H #CE I=@=, IH @G =@I 3

    AC HF=G (AC IF 3 /@, 3R30 /@, JF 30 /@) F !

    HFM = IH @GG=TH= (G GK = H @@K= H@G).

    =G IH H #CE I=@= FJ=KG H @GG=TH= CD.

    K$%8 D%!% I0/' G/"! O#/% GFR #!%'/%

    ! HFM! HFM ! (@/=/1.73! (@/=/1.73 22)) FGFG

    !1 >90 F@ F =

    !2 60R89 =@@M FG*

    !3 45R59 =@@M H FH@M FG

    !3 30R44 FH@M H GJF@M FG

    !4 15R29 JF@M FG

    !5

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    * @H=J H MI I@H @J@

    ** #@I= FH= GMF (AC IGI@@M >220 /@)

    AFJ=H=G: AC, @I=:FH== FH=; CD, F= =M =GG

    F=H K=H F=GG= F =M D=GG: #FJ= !@@ IHG (D#!) CD

    F !FI (2013) D#! 2012 @==@ FH= I=@= F H J@IH=

    H F= =M =GG. =M #HFH=@ (I@. 3): 1R150

    &H FGHH= @ K=H =M =@IF =FGG F==HM, FH@=HM GG=H

    @HF GHG. D=G=G @ K=H =M =GG G =FJ G= H =HFIH=

    H=@ GH=H ! FFH= CD ==HFG = H F=FM F I@=HM IHG

    FKF, @G IG HF =G =FG I@= @H FGG=@ KFGG CD.

    "KJF, @H FGHH= KG GH=@@ FFH G 19% JF@@ = H @ AGG=H='G 2013@ =GHFM FFH.

    HH@ GH CD = E@ = 2009R10 KG GH=H H HK O1.44 O1.45 =@@=,

    K= KG FL=H@M 1.3% @@ " G= = HH MF1

    . F H @ H=G IH KG

    GH F@ F@H HFM F H 2% @ K=H CD HH FFGGG H =M

    =@IF. #H KG GH=H = H = @ HH FL=H@M 7000 LGG GHFG 12,000

    LGG MF=@ =FH=G IFF = @ K=H CD = 2009R10 (F@H=J H -

    F-H I@H= K=HIH CD), K=H GH=H GH HK O174 O178 =@@=. HFH=G = H F@=F =H=TH= FJH= FFGG= H -GH

    =M =GG F @F@M .

    =G I=@= GG H FGG HG =GGIG M IH= H 2008 #CE I= = FG KF

    K H J J=@@, FJ== K I= = FG KF FJ=IG@M

    J= L=GH.

    K IH FG =@I:

    =H=TH= =JGH=H= @ K J F F H F=G J@= CD

    @GG=TH= CD =H=TH= @ H F=G CD @=H=G FFGG=

    H T=H= CD FFGG=

    H F@H=G= HK IH =M =IFM CD

    G@-H CD

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 6 %f 62

    http://kdigo.org/home/guidelines/ckd-evaluation-management/http://kdigo.org/home/guidelines/ckd-evaluation-management/http://www.renalreg.com/Reports/2013.htmlhttp://www.renalreg.com/Reports/2013.htmlhttp://www.renalreg.com/Reports/2013.htmlhttp://www.renalreg.com/Reports/2013.htmlhttp://kdigo.org/home/guidelines/ckd-evaluation-management/http://kdigo.org/home/guidelines/ckd-evaluation-management/
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    FHFM F CD.

    D' %#/%$!/

    I=@= K=@@ GGI HH FGF=FG K=@@ IG FI'G GIFM FIH FHF=GH=G H=F =G=G K=H ==J=I@ H=HG.

    1FF , BFM B, @ $ H @. (2012) EGH=H= H T=@ GH F= =M =GG H

    H " = E@. F@M D=@MG=G FG@HH=. 27 (I@. 3): ===73R80

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 7 %f 62

    http://ndt.oxfordjournals.org/content/early/2012/08/03/ndt.gfs269.fullhttp://ndt.oxfordjournals.org/content/early/2012/08/03/ndt.gfs269.fullhttp://ndt.oxfordjournals.org/content/early/2012/08/03/ndt.gfs269.fullhttp://ndt.oxfordjournals.org/content/early/2012/08/03/ndt.gfs269.full
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    H=H-HF FH=H-HF F

    =G I=@= FG GH FH= J= H F I@HG K=H F= =M =GG.

    H=HG @HF FGG=@G J F=HG FGG==@=H=G G GH IH = H "

    CGH=HIH= F E@ R @@ #CE I= =G KF=HH H FUH HG. FHH F GI@

    H =H IH ==J=I@ G FFG. H=HG GI@ J H FHI=HM H

    =F =G=G IH H=F F HFHH, = FHFG= K=H H=F @HF

    FGG=@G. "@HF FGG=@G GI@ @@K H DFHH "@H'G J=

    GH. # G G H J =HM H =G=G, @HF FGG=@G GI@

    @@K H FH= HH =G H H@ C=HM AH H GI@HFM

    FH= F=JH= @=FHM GIFG.

    #CE G FI I= H HG H=H LF= = I@H " GFJ=G.

    A@@ @HF FGG=@G GI@ @@K H FH=G = H=H LF= = I@H "

    GFJ=G.

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 8 %f 62

    https://www.gov.uk/government/publications/the-nhs-constitution-for-englandhttps://www.gov.uk/government/publications/the-nhs-constitution-for-englandhttps://www.gov.uk/government/publications/reference-guide-to-consent-for-examination-or-treatment-second-editionhttps://www.gov.uk/government/publications/reference-guide-to-consent-for-examination-or-treatment-second-editionhttp://www.justice.gov.uk/protecting-the-vulnerable/mental-capacity-acthttp://webarchive.nationalarchives.gov.uk/20130107105354/http:/www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/DH_085476http://webarchive.nationalarchives.gov.uk/20130107105354/http:/www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/DH_085476http://www.nice.org.uk/guidance/cg138http://www.nice.org.uk/guidance/cg138http://www.nice.org.uk/guidance/cg138http://www.nice.org.uk/guidance/cg138http://webarchive.nationalarchives.gov.uk/20130107105354/http:/www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/DH_085476http://webarchive.nationalarchives.gov.uk/20130107105354/http:/www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/DH_085476http://www.justice.gov.uk/protecting-the-vulnerable/mental-capacity-acthttps://www.gov.uk/government/publications/reference-guide-to-consent-for-examination-or-treatment-second-editionhttps://www.gov.uk/government/publications/reference-guide-to-consent-for-examination-or-treatment-second-editionhttps://www.gov.uk/government/publications/the-nhs-constitution-for-englandhttps://www.gov.uk/government/publications/the-nhs-constitution-for-england
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    M F=F=H=G F =@HH=M F=F=H=G F =@HH=

    @@K= FH=G J =H=T G F=F=H=G F =@HH=. I@@ @=GH

    FH=G =G = GH= 1.

    I%'!/ &/ #/# +$%8 $%!%

    C@==@ @FHF=G GI@:

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    H GHF=G FF HF=@

    IG FH== GGMG HH F G=T (F L@, NMH= GGMG) NF-=G

    F K=H =GH =@IH= GG GHFHFM (#D)

    FH==H = H=@ LHF@ I@=HM GGGGH G F FH==. KK

    20142014

    CG=F IG= !MGHH=C H ==H=@ =G=G H TF F FI@ IH CD = @ K=H:

    !FH== 45R59 @/=/1.73 2, GIGH= F H @GH 90 MG

    FH=IF= (@I=:FH== FH= AC @GG H 3 /@) F HF FF

    =M =GG. K 2014K 2014

    D H =G CD = @ K=H:

    !FH== 45R59 @/=/1.73 2

    !MGHH=C F H 60 @/=/1.73 2

    HF FF =M =GG. K 2014K 2014

    F HGH= F CD IG= !FH== AC H @ K=H M H @@K= F=G

    HFG:

    =HG

    MFHG=

    IH =M =IFM (G FH= 1.3.9)

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 9 %f 62

    http://www.nice.org.uk/guidance/cg182/chapter/recommendationshttp://www.nice.org.uk/guidance/cg182/chapter/recommendations#terms-used-in-this-guidelinehttp://www.nice.org.uk/guidance/cg182/chapter/recommendations#terms-used-in-this-guidelinehttp://www.nice.org.uk/guidance/cg182/chapter/recommendations#terms-used-in-this-guidelinehttp://www.nice.org.uk/guidance/cg182/chapter/recommendations#acute-kidney-injury-and-ckdhttp://www.nice.org.uk/guidance/cg182/chapter/recommendations#acute-kidney-injury-and-ckdhttp://www.nice.org.uk/guidance/cg182/chapter/recommendations#terms-used-in-this-guidelinehttp://www.nice.org.uk/guidance/cg182/chapter/recommendations#terms-used-in-this-guidelinehttp://www.nice.org.uk/guidance/cg182/chapter/recommendations#terms-used-in-this-guidelinehttp://www.nice.org.uk/guidance/cg182/chapter/recommendations
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    F=JGI@F =GG (=G= FH =GG, F= FH =@IF, F=F@

    JGI@F =GG F FF@ JGI@F =GG)

    GHFIHIF@ F@ HFH =GG, FIFFH F@ @I@= F FGHH= MFHFM

    I@H=GMGH =GGG K=H HH=@ =M =J@JH R F L@, GMGH= @IIG

    FMHHGIG

    =@M =GHFM -GH =M =GG (! HFM !5) F F=HFM =M

    =GG

    FHI=GH= HH= HIF=. K 2014K 2014

    C!:#!/ /& #/# +$%8 $%!%

    C@GG=M CD IG= =H= ! AC HF=G (G GF= = H@ 1). B

    KF HH:

    =FG AC =G GG=H K=H =FG F=G JFG IHG

    FG ! =G GG=H K=H =FG F=G JFG IHG

    =FG AC FG ! = =H= I@H=@M H F=G JFG

    IHG. K 2014K 2014

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 10 %f 62

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    T!"% 1 C!:#!/ /& #/# +$%8 $%!% ' GFR !$ ACR #!%'/%

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 11 %f 62

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    F%%#8 /& //'

    G H@ 2 H I= H FIM ! =HF= F @ K=H, F H F=G , CD, IH

    H=@F =H H H FG F= H:

    H IF@M= IG CD

    GH HHFG ! AC (IH KF HH CD FFGG= =G H -@=F)

    F==H=G, G=@@M FH =@IF

    G H H=F HFHH (GI G F=R=HG=R@GHF GMGH AA

    H=GHG, A#DG =IFH=G)

    =HFIFFH =@@GG

    KHF HM J G GFJH=J H CD. K 2014K 2014

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 12 %f 62

    http://www.nice.org.uk/guidance/cg182/chapter/recommendations#terms-used-in-this-guidelinehttp://www.nice.org.uk/guidance/cg182/chapter/recommendations#terms-used-in-this-guidelinehttp://www.nice.org.uk/guidance/cg182/chapter/recommendations#terms-used-in-this-guidelinehttp://www.nice.org.uk/guidance/cg182/chapter/recommendations#terms-used-in-this-guideline
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    T!"% 2 F%%#8 /& //' /& GFR ("% /& % 0% 8%!, "8 GFR !$

    ACR #!%'/8) &/ 0%/0% , / ! + /&, CKD

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 13 %f 62

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    =HF @ F H J@H F FFGG= CD F H @GH 2R3 MFG HF IH=M =IFM, J = GFI FH== G FHIF H G@=. K 2014K 2014

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 14 %f 62

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    11 H=GH=G

    @@K= I= =G G H GH J=@@ J=. I@@ I=@= =JG H=@G

    H HG H J= IG H J@ H I=.

    KF= IG = H FH=G = H=G I=@= (F L@, KFG GI G 'F'

    'G=F') HG H FH=HM K=H K= H FH= =G (H GHFH

    H FH=). IH H=G I=@= F H=@G.

    T% %$ '$%%

    CF= =CF= =M =GG (M =GG (CDCD))

    DT G F@=H=G =M IH= F GHFIHIF FGH F F H 3 HG, K=H

    =@=H=G F @H. =G =@IG @@ @ K=H FFG =M HG K=H

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    C@GG=TH= CDC@GG=TH= CD

    CD =G @GG=T F= H GH=H ! (!) @I=:FH== FH= (AC) (G H@1), IG= '!' H H H ! HFM (!1R!5, K= J H G ! HFG@G G H CD

    GHG 1R5 F FJ=IG@M) 'A' F H AC HFM (A1RA3), F L@:

    A FG K=H ! 25 @/=/1.73 2

    AC 15 /@ G CD !4A2.

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    A ! @GG H 15 @/=/1.73 2

    (! HFM !5) =G FFF H G =M =@IF.

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    !FH==: GH=H= ! IG= GFI FH==

    !MGHH=C: GH=H= ! IG= MGHH= C.

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 15 %f 62

    http://www.nice.org.uk/Guidance/CG182/Evidence/http://www.nice.org.uk/guidance/CG182/chapter/About-this-guidelinehttp://www.nice.org.uk/guidance/cg182/chapter/key-priorities-for-implementation#table-1-classification-of-chronic-kidney-disease-using-gfr-and-acr-categorieshttp://www.nice.org.uk/guidance/cg182/chapter/key-priorities-for-implementation#table-1-classification-of-chronic-kidney-disease-using-gfr-and-acr-categorieshttp://www.nice.org.uk/guidance/cg182/chapter/key-priorities-for-implementation#table-1-classification-of-chronic-kidney-disease-using-gfr-and-acr-categorieshttp://www.nice.org.uk/guidance/cg182/chapter/key-priorities-for-implementation#table-1-classification-of-chronic-kidney-disease-using-gfr-and-acr-categorieshttp://www.nice.org.uk/guidance/CG182/chapter/About-this-guidelinehttp://www.nice.org.uk/Guidance/CG182/Evidence/
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    FFFG =FG =M =GGM =GG

    G =@I @I=IF= (AC F H 3 /@), IF= G=H F@=H=G, @HF@MH

    HF F@=H=G I H HII@F =GFFG, F@=H=G HH M =GH@M, GHFIHIF@

    F@=H=G HH M ==, =GHFM =M HFG@HH=.

    =R=HG=R@GHF GMGH H=GH=R=HG=R@GHF GMGH H=GH

    A FI HH @G F ===HG H F=R=HG=R@GHF GMGH =@I= =HG=-

    JFH= NM (ACE) ===HFG, =HG=-FHF @FG (ABG), =FH F= ===HFG

    @GHF H=GHG.

    =R=HG= GMGH H=GH=R=HG= GMGH H=GH

    A FI HH @G F ===HG H F=R=HG= GMGH =@I= ACE ===HFG, ABG

    =FH F= ===HFG. =G FI FIG G H =@I @GHF H=GHG.

    1.1 I%'!/ &/ #/# +$%8 $%!%

    GIF= =GIF= =M IH=M IH=

    CC%!%-"!%$ %!% /& GFR%!%-"!%$ %!% /& GFR

    1.1.1 JF FIGH F GFI FH== GIFH =G , @==@

    @FHF=G GI@ FFH GH=H @FI@F T@HFH= FH

    (!FH==) IG= F=H= IH= (G FH= 1.1.2) =

    =H= H FFH= H GFI FH== FGI@H2

    . 20142014

    1.1.2 C@==@ @FHF=G GI@:

    IG H CF= =M D=GG E==@M C@@FH= (CD-E#) FH==

    IH= H GH=H !FH==, IG= FH== GGMG K=H @=FH= HF@

    H GHF=G FF HF=@

    IG FH== GGMG HH F G=T (F L@, NMH= GGMG) NF-=G

    F K=H =GH =@IH= GG GHFHFM (#D)

    FH==H = H=@ LHF@ I@=HM GGGGH G F FH==. KK

    20142014

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 16 %f 62

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    F F =FH= IH =@H= H=G FH=, G =@HH=:

    HH= GHFH.

    1.1.3 A@M FFH= HF H ! J@IG GH=H IG= H CD-E# FH==

    IH= F @ AF=-CF= F AF= =@M F== (I@H=@M! M 1.159). K 2014K 2014

    1.1.4 # @ K=H LHFG IG@ GG R F L@, = MI=@FG, @

    K J IHH= F @ K=H IG@ KGH= =GFFG R

    =HFFH !FH== K=H IH=. (I IG@ GG K=@@ @ H

    JFGH=H= =FG IG@ GG H IFGH=H= H !.)

    20082008

    1.1.5 AJ=G @ H H H M H = H 12 IFG F J= @ HGH F

    !FH==. AJ= @M= H GH @ G@G H GIF HH

    HM F F=J FGG M H @FHFM K=H= 12 IFG

    JIHIF. 20082008

    C8! CC8! C-"!%$ %!% /& GFR-"!%$ %!% /& GFR

    1.1.6 JF FIGH F GFI MGHH= C GIFH =G , @==@

    @FHF=G GI@ FFH GH=H @FI@F T@HFH= FH

    (!MGHH=C) IG= F=H= IH= (G FH= 1.1.7) =

    =H= H FFH= H GFI MGHH= C FGI@H. K 2014K 2014

    1.1.7 =FJ GGGGH F=G =G (G FH= 1.1.14),

    @==@ @FHF=G GI@ IG H CD-E# MGHH= C IH= H GH=H

    !MGHH=C. K 2014K 2014

    1.1.8 C@==@ @FHF=G GI@ IG MGHH= C GGMG @=FH H H =HFH=@GHF H GIF GFI MGHH= C F MGHH= C-G GH=HG !.

    K 2014K 2014

    1.1.9 #HFFH !MGHH=C K=H IH= = @ K=H IHF@@ HMF=

    =GG IG !MGHH=C J@IG M @G@M @JH = @ K=H

    MHMF==G FI = @ K=H MFHMF==G. K 2014K 2014

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 17 %f 62

    http://www.nice.org.uk/guidance/cg182/chapter/implementation-getting-startedhttp://www.nice.org.uk/guidance/cg182/chapter/implementation-getting-startedhttp://www.nice.org.uk/guidance/cg182/chapter/implementation-getting-startedhttp://www.nice.org.uk/guidance/cg182/chapter/implementation-getting-started
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    R%0/' !$ %0R%0/' !$ %0%' GFR %' GFR !%!%

    1.1.10 C@==@ @FHF=G GI@ FFH ! =HF G K@ IF = =H =G 90 @/

    =/1.73 2

    F @GG, F G 'FHF H 90 @/=/1.73 2'. K 2014K 2014

    1.1.11 # ! =G FHF H 90 @/=/1.73 2, IG =FG = GFI FH==

    HFH= F H 20% H =F G==TH FIH= = =M

    IH=. K 2014K 2014

    1.1.12 #HFFH ! J@IG 60 @/=/1.73 2

    F F K=H IH=, F= =

    = HH GH=HG ! @GG IFH G H HFI ! =FGG.

    20142014

    1.1.13 CTF ! FGI@H @GG H 60 @/=/1.73 2

    = FG H

    FJ=IG@M HGH M FH= H HGH K=H= 2 KG. A@@K F =@=@

    @MH=@ JF==@=HM GFI FH== (Q5%) K =HFFH= G =

    !. 20082008

    W% / % ! #8! CW% / % ! #8! C-"!%$ %!% /& GFR &/ $!'/ /& CKD-"!%$ %!% /& GFR &/ $!'/ /& CKD

    1.1.14 CG=F IG= !MGHH=C H ==H=@ =G=G H TF F FI@ IH CD =

    @ K=H:

    !FH== 45R59 @/=/1.73 2, GIGH= F H @GH 90 MG

    FH=IF= (@I=:FH== FH= AC @GG H 3 /@) F HF FF

    =M =GG. K 2014K 2014

    F =FH= IH =@H= H=G FH=, G =@HH=:

    HH= GHFH.

    1.1.15 D H =G CD = @ K=H:

    !FH== 45R59 @/=/1.73 2

    !MGHH=C F H 60 @/=/1.73 2

    HF FF =M =GG. K 2014K 2014

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 18 %f 62

    http://www.nice.org.uk/guidance/cg182/chapter/recommendations#markers-of-kidney-diseasehttp://www.nice.org.uk/guidance/cg182/chapter/recommendations#markers-of-kidney-diseasehttp://www.nice.org.uk/guidance/cg182/chapter/implementation-getting-startedhttp://www.nice.org.uk/guidance/cg182/chapter/implementation-getting-startedhttp://www.nice.org.uk/guidance/cg182/chapter/recommendations#markers-of-kidney-diseasehttp://www.nice.org.uk/guidance/cg182/chapter/recommendations#markers-of-kidney-diseasehttp://www.nice.org.uk/guidance/cg182/chapter/implementation-getting-startedhttp://www.nice.org.uk/guidance/cg182/chapter/implementation-getting-startedhttp://www.nice.org.uk/guidance/cg182/chapter/recommendations#markers-of-kidney-diseasehttp://www.nice.org.uk/guidance/cg182/chapter/recommendations#markers-of-kidney-disease
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    W% '8 !##W% '8 !##!% %!!% %!% /& GFR !% /& GFR !% % %%%$%$

    1.1.16 F =@M IFH GIF ! =G FI=F R F L@, IF=

    =HF= HFM = H J@IH= F@ IH= = HH=@

    @=J= FG R G=F FF GHF GIF (=I@=, 51CF-EDA,125

    #-=H@H F =L@). 20082008

    FH=IF=FH=IF=

    1.1.17 D H IG FH GHF=G H =H=M FH=IF= I@GG HM F @

    G=T@@M GIF= @I= H @K HFH=G LFGG= H FGI@H

    G AC. 20082008

    1.1.18 HH =H=M FH=IF=, IG IF= AC = FF H

    FH=:FH== FH= (C), IG =H G FHF GG=H=J=HM H C F

    @K @J@G FH=IF=. F IH=TH= =HF= @J@G

    FH=IF= AC 70 /@ F F, C IG G @HFH=J.

    AC =G H F H F @ K=H =HG. 2008, 2008,

    20142014

    1.1.19 F H ==H=@ HH= FH=IF=, = H AC =G HK 3 /@

    70 /@, H=G GI@ TF M GIGIH F@M F= G@. #

    H ==H=@ AC =G 70 /@ F F, FH G@ H HGH.

    2008, 20142008, 2014

    1.1.20 F TF AC 3 /@ F F G @==@@M =FHH

    FH=IF=. 2008, 20142008, 2014

    1.1.21 IH=M IF=FM @I= F IF=FM FH= @GG G = FH= 1.1.18

    F:

    @ K=H =HG

    @ K=HIH =HG K=H ! @GG H 60 @/=/1.73 2. 2008, 2008,

    20142014

    1.1.22 IH=M M @FHFM HGH= H IF=FM @I= F IF=FM FH= @GG

    @ K=H ! 60 @/=/1.73 2

    F F = HF =G GHF GIG==

    CD (G @G FH= 1.1.28). 20082008

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 19 %f 62

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    "HIF="HIF=

    1.1.23 HGH= F H FG HIF=, IG FH GHF=G FHF H

    IF= =FGM.

    EJ@IH IFHF = HF =G FGI@H 1+ F F.

    D H IG IF= =FGM H TF G=H=J FGI@H. 20082008

    = =G@H == =G@H =J=G=@ HIF=J=G=@ HIF=

    1.1.24 HF =G H H =FH=H FG=GHH =J=G=@ HIF= = H

    G FH=IF= F HFG=H HIF=, FF 2 IH 3 G=H=J

    FH GHF= HGHG G TFH= FG=GHH =J=G=@ HIF=. 20082008

    1.1.25 FG=GHH =J=G=@ HIF=, K=H F K=HIH FH=IF=, GI@ FH

    =JGH=H= F IF=FM HFH @=M = FF=H FIG. 20082008

    1.1.26 FG=GHH =J=G=@ HIF= = H G FH=IF= GI@ @@K

    I I@@M K=H FH HGH= F HIF= (G FH=G 1.1.24

    1.1.25), FH=IF= F @I=IF=, ! @ FGGIF =HF= G

    @ G H HIF= FG=GHG. 20082008

    GI@ HGH F CD GI@ HGH F CD

    1.1.27 =HF ! H @GH I@@M = @ FGF= FIG K H

    FHL=, GI G @=IF= ===HFG (F L@, M@GF= F

    HF@=IG), @=H=I -GHF=@ H=-=UHFM FIG (A#DG). 2008,2008,

    2014 2014

    1.1.28 F HGH= F CD IG= !FH== AC H @ K=H M H

    @@K= F=G HFG:

    =HG

    MFHG=

    IH =M =IFM (G FH= 1.3.9)

    F=JGI@F =GG (=G= FH =GG, F= FH =@IF, F=F@JGI@F =GG F FF@ JGI@F =GG)

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 20 %f 62

    http://www.nice.org.uk/guidance/cg182/chapter/recommendations#acute-kidney-injury-and-ckdhttp://www.nice.org.uk/guidance/cg182/chapter/recommendations#acute-kidney-injury-and-ckd
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    GHFIHIF@ F@ HFH =GG, FIFFH F@ @I@= F FGHH= MFHFM

    I@H=GMGH =GGG K=H HH=@ =M =J@JH R F L@, GMGH= @IIG

    FMHHGIG

    =@M =GHFM -GH =M =GG (! HFM !5) F F=HFM =M

    =GG

    FHI=GH= HH= HIF=. K 2014K 2014

    1.1.29 D H IG , F F H==HM G F=G FFG H HGH @ F CD. #

    H G H@= GMF, =HG F MFHG=, H IG

    G=HM @ G F=G FF H HGH @ F CD. 2008, 20142008, 2014

    1.2 C!:#!/ /& #/# +$%8 $%!%

    1.2.1 C@GG=M CD IG= =H= ! AC HF=G (G GF= =

    H@ 1). B KF HH:

    =FG AC =G GG=H K=H =FG F=G JFG IHG

    FG ! =G GG=H K=H =FG F=G JFG IHG

    =FG AC FG ! = =H= I@H=@M H F=G JFG

    IHG. K 2014K 2014

    F =FH= IH =@H= H=G FH=, G =@HH=:

    HH= GHFH.

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 21 %f 62

    http://www.nice.org.uk/guidance/cg182/chapter/implementation-getting-startedhttp://www.nice.org.uk/guidance/cg182/chapter/implementation-getting-startedhttp://www.nice.org.uk/guidance/cg182/chapter/implementation-getting-startedhttp://www.nice.org.uk/guidance/cg182/chapter/implementation-getting-started
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    @ 1 C@GG=TH= F= =@ 1 C@GG=TH= F= =M =GG IG= ! AM =GG IG= ! AC HF=GC HF=G

    1.2.2 D H HF= H CD G@@M M . K 2014K 2014

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 22 %f 62

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    ##JJGH=H= H IG CD HF== H F=G JGH=H= H IG CD HF== H F=G JFG IHGFG IHG

    1.2.3 AF @ H GH@=G H IG CD IF= =F =GIGG= K=H

    H FG K=H CD, FH=I@F@M = H IG M HFH@ (F L@,

    IF=FM HFH GHFIH=, FHL= FIG F @FI@F =GG). K 2014K 2014

    1.2.4 G H FG'G ! AC HF=G (G H@ 1) H ==H H=F F=G

    JFG IHG (F L@, CD FFGG=, IH =M =IFM, @@-IG

    FH@=HM F=JGI@F JHG) =GIGG H=G K=H H. K 2014K 2014

    #=H=G F F@ I@HF#=H=G F F@ I@HFGIGI

    1.2.5 F F@ I@HFGI G H @@ @ K=H CD K:

    J @FH FFGG= CD (G FH= 1.3.3)

    J J=G=@ F FG=GHH =J=G=@ HIF=

    J GMHG IF=FM HFH GHFIH=

    J =@M =GHFM @MMGH= =M =GG F JF 20 MFG

    J ! @GG H 30 @/=/1.73 2

    (! HFM !4 F !5)

    F G=F M F@=GH H FI=F F@ =GM. 2008, 20142008, 2014

    1.2.6 AJ=G @ K=H =@M =GHFM =F=H =M =GG IH H

    =@=H=G F@ FGI@H F F@ I@HFGI G =G FF F

    H. 20082008

    1.3 F%%#8 /& //'

    1.3.1 AF H FIM =HF= (!FH== AC) K=H H FG

    K=H, F H F=G , CD; F = = HH CD =G H FFGG=J = M @.

    K 2014K 2014

    1.3.2 G H@ 2 H I= H FIM ! =HF= F @ K=H, F H F=G

    , CD, IH H=@F =H H H FG F= H:

    H IF@M= IG CD

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 23 %f 62

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    GH HHFG ! AC (IH KF HH CD FFGG= =G H -

    @=F)

    F==H=G, G=@@M FH =@IF

    G H H=F HFHH (GI G F=R=HG=R@GHF GMGH AA

    H=GHG, A#DG =IFH=G)

    =HFIFFH =@@GG

    KHF HM J G GFJH=J H CD. K 2014K 2014

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 24 %f 62

    http://www.nice.org.uk/guidance/cg182/chapter/recommendations#terms-used-in-this-guidelinehttp://www.nice.org.uk/guidance/cg182/chapter/recommendations#terms-used-in-this-guidelinehttp://www.nice.org.uk/guidance/cg182/chapter/recommendations#terms-used-in-this-guidelinehttp://www.nice.org.uk/guidance/cg182/chapter/recommendations#terms-used-in-this-guideline
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    @ 2 @ 2 FIM =HF= ! (IF H=G F MFIM =HF= ! (IF H=G F MFF, , M ! AM ! ACC

    HFM) F @ K=H, F H F=G HFM) F @ K=H, F H F=G , CD, CD

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 25 %f 62

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    DT= FFGG=DT= FFGG=

    1.3.3 DT @FH FFGG= CD G:

    GIGH= FG = ! 25% F F = ! HFM K=H=12 HG FF

    GIGH= FG = ! 15 @/=/1.73 2

    F MF. K 2014K 2014

    1.3.4 H @@K= GHG H =H=M H FH FFGG= CD:

    H= ==I 3 ! GH=H=G JF F= H @GG H 90 MG.

    # @ K=H K T= FI !, FH H ! K=H= 2 KG H L@IIGG IH HF=FH= ! R F L@, IH =M =IFM F GHFH=

    F=R=HG= GMGH H=GH HFM. 2008, 20142008, 2014

    1.3.5 B KF HH @ K=H CD F H =FG F=G FFGG= H -

    GH =M =GG = HM J =HF H @@K=:

    GIGH= FG = ! 25% F F JF 12 HG FF

    GIGH= FG = ! 15 @/=/1.73 2

    F F JF 12 HG. 2008,2008, 2014 2014

    1.3.6 GGGG= CD FFGG=, LHF@H H IFFH FH @=

    ! H H=G =H IH K @= =HFJH= GHFH=G,

    FH=I@F@M = =H GIGHG HH H FG =H F@ F@H HFM

    = H=F @=H=. 2008, 20142008, 2014

    =G HFG GG=H K=H CD FFGG==G HFG GG=H K=H CD FFGG=

    1.3.7 F K=H @ K J M H @@K= F=G HFG F CD

    FFGG= H H==G H=F @H:

    F=JGI@F =GG

    FH=IF=

    IH =M =IFM

    MFHG=

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 26 %f 62

    http://www.nice.org.uk/guidance/cg182/chapter/recommendations#terms-used-in-this-guidelinehttp://www.nice.org.uk/guidance/cg182/chapter/recommendations#terms-used-in-this-guideline
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    =HG

    G=

    AF=, AF=-CF= F AG= =@M F==

    F= IG A#DG

    IHFH IF=FM IHUK HFH GHFIH=. K 2014K 2014

    1.3.8 # @ K=H CD H F= IG A#DG M GG=H K=H

    FFGG= IH IG =G GG=H K=H FJFG=@ FG = !.

    ELF=G IH= K HFH= @ K=H CD K=H A#DG JF F@

    F=G H=. =HF H HG !, FH=I@F@M = @ K=H @K

    G@= ! /F = H FG HF F=GG F FFGG=. 20082008

    AIH =AIH =M =IFM CDM =IFM CD

    1.3.9 =HF @ F H J@H F FFGG= CD F H @GH

    2R3 MFG HF IH =M =IFM, J = GFI FH== G FHIF H

    G@=. K 2014K 2014

    1.3.10 AJ=G @ K J IH =M =IFM HH HM F H =FG F=G CD J@= F FFGG=. K 2014K 2014

    1.4 I&/!/ !$ %$#!/

    1.4.1 F @ K=H CD IH= =FH= H=@F H H GJF=HM

    IG CD, H GG=H @=H=G H F=G FFGG=. 20082008

    1.4.2 J@= =FH= F IH= FFG, =J@J @ K=HCD = H=F J@H F H IHGH. @@K= H=G F GIGH.

    H =G CD K G =H H @?

    H IGH=G GI@ @ G IH H=F =MG?

    H HFHHG F J=@@ F CD, KH F H=F JHG =GJHG

    KH @=H=G F G= HG M IF G FGI@H HFHH/=H=?

    H @ H =UI H=F K =H=?

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 27 %f 62

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    # KH KMG I@ CD =HG HFHH H @'G =@M @=, G=@ H=J=H=G,

    KF FHI=H=G T=@ G=HIH=, =@I= THG @@KG J=@@?

    "K @ K=H IGH H CD KH GIFG GM@=@

    GIFH F J=@@?

    FF=H, F =FH= IH F@ F@H HFM (GI G H

    FIM @H H= =@MG=G HFHH GGG=G F LG F-

    H=J HFG@HH=) H FFH= FI=F (GI G J= TGHI@ F

    F=H@ HHF).

    CGFJH=J H K =H M G=F. 20082008

    1.4.3F @ K=H CD =-I@=HM =FH= F IH= FFG GFF=H H H GJF=HM H=F =H= H @@K H= F H H I@@M

    IFGH =F =G IH H=F HFHH. 20082008

    1.4.4 "@HF FGG=@G FJ== =FH= IH= FFG

    GI@ GIF HM J G=@=GH K@ IH CD H GGFM

    G=@@G H =@=HH @F=. 20082008

    1.4.5 "@HF FGG=@G KF= K=H @ K=H CD GI@ H IH

    H GM@=@ GHG = K=H H =H= F GG H

    FF=H GIFH R F L@, GIFH FIG, IG@@= F G=@=GH

    IFG. 20082008

    &=GHM@ J=&=GHM@ J=

    1.4.6 EIF @ K=H CD H H LF=G, =J @HM K=H GH

    G=. 20082008

    D%!8 %D%!8 %%/%/

    1.4.7 F =HFM J= IH HGG=I, GH, @F= G@H =H

    FF=H H H GJF=HM CD. 2008, 20142008, 2014

    1.4.8 F =HFM =HFJH= =G F H=G GI@ IF K=H= H HLH

    IH=, H=@ =HFM GGGGH GIFJ=G= H GIF @IHF=H=

    =G FJH. 20082008

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 28 %f 62

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    L/-0L/-0/% $%/% $%

    1.4.9 D H F @K-FH= =HG (=HFM FH= =H @GG H 0.6R0.8 //

    M) H @ K=H CD. K 2014K 2014

    @-H@-H

    1.4.10 EGIF HH GMGHG F = @ H:

    =F @ K=H CD H=F =G=G

    @ @ K=H CD H GF = =G=-= IH H=F F

    GIFH G@-H (H=G =@IG FJ== =FH= IH @ FGGIF,G= GGH=, LF=G, =H ==G) @ @ H =F

    =G. K 2014K 2014

    1.4.11 !=J @ GG H H=F =@ H (=@I= =G=G, F==H=G, HGH

    FGI@HG, HFHHG FFG) HFI =FH= GMGHG, GI G

    @ H=H=K, H IF @ H H G@- H=F CD. KK

    20142014

    1.5 R%&%! #%!

    1.5.1 =H IH H ==J=I@'G K=GG F==H=G K G=F=

    FFF@. 20082008

    1.5.2 @ K=H CD = H @@K= FIG GI@ F@@M FFF F

    G=@=GH GGGGH:

    ! @GG H 30 @/=/1.73 2 (! HFM !4 F !5), K=H F K=HIH =HG

    AC 70 /@ F F, I@GG K H IG M =HG @FM

    FF=H@M HFH

    AC 30 /@ F F (AC HFM A3), HHF K=H HIF=

    GIGH= FG = ! 25% F F, = ! HFM F GIGH=

    FG = ! 15 @/=/1.73 2

    F F K=H= 12 HG

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 29 %f 62

    https://www.patientview.org/https://www.patientview.org/
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    MFHG= HH F=G F@M HF@@ G=H H IG H @GH 4

    H=MFHG=J FIG H HFIH= GG (G @G "MFHG= #CE I=@=

    C!127)

    K F GIGH FF F H= IGG CD

    GIGH F@ FHFM GHG=G. 2008, 20142008, 2014

    1.5.3 CG=F =GIGG= H =GGIG K=H G=@=GH M @HHF, =@ F

    H@ = GG KF =H M H GGFM F H FG K=H CD H

    G M H G=@=GH. 20082008

    1.5.4 FFF@ G @ =H@M F (HK H FG

    K=H CD F H=F FF H @HF FGG=@), =H M GG=@ FFIH= @@K-I H H @ H H H=H'G ! GIFFM FHF H =

    G=@=GH @==. # H=G =G H G, F=HF= F IHIF FFF@ F F-FFF@ GI@

    G=T. 20082008

    1.5.5 @ K=H CD F@ IHUK GHFIH= GI@ F@@M FFF H

    IF@=@ GFJ=G, I@GG IFH =@ =HFJH= =G FI=F R F

    L@, F H HFHH MF@=, GJF IF=, =G=G F UI=

    JF@. 20082008

    1.6 P!!#/%!08

    B@ FGGIF HF@B@ FGGIF HF@

    1.6.1 # @ K=H CD = H H GMGH@= @ FGGIF @K 140 "

    (HFH F 120R139 ") H =GH@= @ FGGIF @K

    90 "3

    . 20082008

    1.6.2 # @ K=H CD =HG, @G = @ K=H AC 70 /

    @ F F, = H H GMGH@= @ FGGIF @K 130 " (HFH

    F 120R129 ") H =GH@= @ FGGIF @K 80 "3

    .

    20082008

    C= H=C= H=MFHG=JMFHG=J H H

    1.6.3 F @K-GH F=R=HG= GMGH H=GH H @ K=H CD :

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 30 %f 62

    http://www.nice.org.uk/guidance/cg127http://www.nice.org.uk/guidance/cg182/chapter/recommendations#terms-used-in-this-guidelinehttp://www.nice.org.uk/guidance/cg182/chapter/recommendations#terms-used-in-this-guidelinehttp://www.nice.org.uk/guidance/cg127
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    =HG AC 3 /@ F F (AC HFM A2 F A3)

    MFHG= AC 30 /@ F F (AC HFM A3)

    AC 70 /@ F F (=FFGH=J MFHG= F F=JGI@F

    =GG)4

    . K 2014K 2014

    1.6.4 D H F =H= F=R=HG= GMGH H=GHG H @

    K=H CD. K 2014K 2014

    1.6.5 @@K H HFHH FH=G = "MFHG= (#CE I=@=

    C!127) F @ K=H CD, MFHG= AC @GG H 30 /

    @ (AC HF=G A1 A2), = HM H J =HG. K 2014K 2014

    1.6.6 =FJ F, =F @ K F FGF= F=R=HG=

    GMGH H=GHG IH H =FH :

    =J= H H=@ H@FH G F=R=HG= GMGH H=GHG

    =HF= ! GFI HGG=I = =J= H=G G@M. 20082008

    1.6.7 # @ K=H CD, GIF GFI HGG=I HFH=G GH=H H

    ! F GHFH= F=R=HG= GMGH H=GHG. H HG

    GIFHG HK 1 2 KG HF GHFH= F=R=HG= GMGH

    H=GHG HF G =FG. 20082008

    1.6.8 D H FIH=@M F F=R=HG= GMGH H=GH H @ K=H

    CD = H=F FHFHH GFI HGG=I HFH= =G FHF H

    5.0 @/@=HF. 2008, 20142008, 2014

    1.6.9 MF@= F@IG IG F=R=HG= GMGH H=GHG,GGGGH, =JGH=H= HFHH HF HFG K H FH

    MF@= GI@ IFH H GFI HGG=I HFH=

    F. 20082008

    1.6.10 CIFFH FGF=H= FIG K H FH MF@= =G H

    HF==H= H H IG F=R=HG= GMGH H=GHG, IH

    KF HH F FIH =HF= GFI HGG=I HFH= M

    FI=F. 20082008

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 31 %f 62

    http://www.nice.org.uk/guidance/cg127http://www.nice.org.uk/guidance/cg127
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    1.6.11 H F=R=HG= GMGH H=GHG = H GFI HGG=I

    HFH= =FGG H 6.0 @/@=HF F F HF FIG K H

    FH MF@= J =GH=I. 20082008

    1.6.12 @@K= H =HFIH= F G =FG F=R=HG= GMGH

    H=GHG, H =M H G = =HF H ! FG F

    FHFHH G@= =G @GG H 25% F H GFI FH== =FG F

    G@= =G @GG H 30%. 20082008

    1.6.13 # HF =G FG = ! F =FG = GFI FH== HF GHFH= F

    =FG= H G F=R=HG= GMGH H=GHG, IH =H =G @GG H

    25% (!) F 30% (GFI FH==) G@=, FH H HGH = 1R2 KG.

    D H =M H F=R=HG= GMGH H=GH G = H =! =G @GG H 25% F H = GFI FH== =G @GG H 30%. 20082008

    1.6.14 # H ! =G 25% F F, F H = GFI FH== =G 30% F

    F:

    =JGH=H HF IGG HF=FH= = F@ IH=, GI G J@I @H=

    F IFFH =H= (F L@, A#DG)

    = HF IG F H HF=FH= = F@ IH= =G I, GH H

    F=R=HG= GMGH H=GH F FI H G H FJ=IG@M H@FH

    @KF G, @HFH=J H=MFHG=J =H= = FI=F. 20082008

    HH=GHH=G

    1.6.15 @@K H FH=G = &== =TH= (#CE I=@= C!181) F

    H IG GHH=G = CD. K 2014K 2014

    FF@ H=@H@HG H=I@HG@ H=@H@HG H=I@HG

    1.6.16 F H=@H@H FIG H @ K=H CD F H GFM FJH=

    F=JGI@F =GG, IH KF H =FG F=G @=. KK

    20142014

    1.6.17 CG=F =L = FF H KFF= = @ K=H TF !

    30R50 @/=/1.73 2

    -J@JI@F HF=@ TF=@@H= K J 1 F F

    H @@K= F=G HFG:

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 32 %f 62

    http://www.nice.org.uk/guidance/cg181http://www.nice.org.uk/guidance/cg181
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    F=F GHF F HFG=H =G= HH

    75 MFG F @F

    MFHG=

    =HG @@=HIG

    GMHH= FH =@IF. K 2014K 2014

    1.7 O% #/0#!/

    B H@=G GHFG=GB H@=G GHFG=G

    1.7.1 D H FIH=@M GIF @=I, GH, FHMF= F (")

    J=H= D @J@G = @ K=H ! 30 @/=/1.73 2

    F F (!

    HFM !1, !2 F !3). 20082008

    1.7.2 GIF GFI @=I, GH " HFH=G = @ K=H

    ! @GG H 30 @/=/1.73 2

    (! HFM !4 F !5). DHF= H

    GIGIH FIM HGH= M H GIF J@IG H @==@

    =FIGHG. F IH L=GHG, G G=@=GH ==. 20082008

    1.7.3 F =GGHG = ==H F H FJH= HFHH

    GHFG=G = @ K=H ! 30 @/=/1.73 2

    F F (! HFM

    !1, !2 F !3). 20082008

    V! D 00%% % !!'%% /& CKD9%V! D 00%% % !!'%% /& CKD9%! !$ "/% $/! !$ "/% $/$%$%

    DH=@ J= H H CDR=F@ =GFFG =G M H G

    H=G I=@=. # IFH=, G J= F MIF @@ F@ GFJ=.

    1.7.4 D H FIH=@M F J=H= D GI@HH= H F FJH

    CDR=F@ =GFFG. K 2014K 2014

    1.7.5 F @@=F@ F F@=F@ H HFH J=H= D T=M = @ K=H

    CD J=H= D T=M. K 2014K 2014

    1.7.6 # J=H= D T=M G FFH GMHG CDR=F@

    =GFFG FG=GH, F @@=@ (1-@-MFLM@@=F@) F

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 33 %f 62

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    @=HF=@ (1-25-=MFLM@@=F@) H @ K=H ! @GG H

    30 @/=/1.73 2

    (! HFM !4 F !5). K 2014K 2014

    1.7.7 =HF GFI @=I GH HFH=G = @ F=J=

    @@=@ F @=HF=@ GI@HG. 20142014

    A=A=

    1.7.8 # H @FM GIF, H @= @J@ = @ K=H !

    @GG H 45 @/=/1.73 2

    (! HFM !3, !4 F !5) H =H=M =

    (@= @GG H 110 /@=HF 11.0 /@, G A= H =

    @ K=H F= =M =GG #CE I=@= C!114). DHF= H

    GIGIH FIM HGH= M H GIF J@I H @==@=FIGHG. 20082008

    FF@ =FH GI@HG = H H H@= =G=G@ =FH GI@HG = H H H@= =G=G

    DH=@ J= H H H@= =G=G =G M H G H=G I=@=. #

    IFH=, G J= F MIF @@ F@ GFJ=.

    1.7.9 CG=F F@ G=I =FH GI@HH= F @ K=H H:

    ! @GG H 30 @/=/1.73 2

    (! HFM !4 F !5)

    GFI =FH HFH= @GG H 20 @/@=HF. K 2014K 2014

    2!FH== M @GG F@=@ = FH= G=HIH=G (F L@, IH =M =IFM,

    FM, HIG GHHG, IG@ KGH= =GFFG, = @ K F @IF=G F

    J IHH=) G H K@@ J@=H = FH= H= FIG (F L@, =

    @ AG= =@M F==).

    3 !D! GF F F=G J= @ FGGIF HF@, = H GH IH H

    GH@=G T=H=J G FG @ FGGIF = CD. J= FGH = H I@@

    I=@= G H HFF =@I GHM @K @ FGGIF, IH G GI J= G

    L=GH. !D! GH IH F @ FGGIF HFHG, =J = HG FH=G, K= =

    H=F @==@ LF= K=@@ =F FH= = CD.

    4

    J= H GIFH HG F=HF= =G @==H = @ JF 70 MFG.

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 34 %f 62

    http://www.nice.org.uk/guidance/cg114http://www.nice.org.uk/guidance/cg114http://www.nice.org.uk/guidance/cg114http://www.nice.org.uk/guidance/cg114
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    22 #@HH=: HH= GHFH#@HH=: HH= GHFH

    =G GH= =@=HG G =FHH G H FH= HH M FGI@H F =@H= H=G

    I=@=, K= KF =H=T H H H= I@=H= = $I@M 2014. =H =IH F

    GH@FG, LFHG @H FGG=@G, 3 FG KF =H=T HH M J = =H

    FH= F I@ @@= H =@H. "KJF, HF G H FH= M

    H I@@M =@H H I=@=.

    F=FM F FJ=FG, @FHFM GFJ=G H=F FGH=J =GG=FG M FH=I@F@M

    H M HG G.

    2.1 C!#!' %!% /& #%!%-"!%$ '/%! :!/ !% (GFR)

    FH= 1.1.2.

    HH=@ =H =@HH=HH=@ =H =@HH=

    CF= =M D=GG E==@M C@@FH= (CD-E#) FH== IH= =G F

    IFH H H =TH= D=H = @ D=GG (DD) HIM IH=, =G @GG =G H

    ! F H 60 @/=/1.73 2

    FFG HHF = @ 75 MFG JF.

    IG H DD HIM IH= M JF-=G CD. G= H CD-E# IH= =GH

    I@ TH H=HG @===G M FI= IGGFM =HHG, FI= H=HG'

    FG FI= H JF@@ IF CD = H I@H=.

    C@@G F =@HH=C@@G F =@HH=

    &FHF=G IG= H DD HIM IH= H GH=H ! M H H=F

    FH=.

    G= H CD-E# FH== IH= H GH=H ! M =H =TI@H H GGGG HFGJF H= = @ K=H FJ=IG ! GH=HG @I@H IG= HF IH=G.

    &FHF=G M H IH H=F GHKF H =@I H CD-E# FH== IH= G

    HH =H =G IG IHH=@@M.

    IFH F =@HH=IFH F =@HH=

    @= H@G IG H =J GH=HG ! IG= H DD HIM IH= (F

    L@, HG FI M H @ AGG=H= H H=@ =M D=GG EIH=FF H DD.), F F=G K=H CD-E# FGI@HG.

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 35 %f 62

    http://www.nice.org.uk/guidance/cg182/chapter/recommendations#investigations-for-chronic-kidney-disease-2http://egfrcalc.renal.org/http://nkdep.nih.gov/lab-evaluation/gfr-calculators.shtmlhttp://nkdep.nih.gov/lab-evaluation/gfr-calculators.shtmlhttp://mdrd.com/http://mdrd.com/http://nkdep.nih.gov/lab-evaluation/gfr-calculators.shtmlhttp://nkdep.nih.gov/lab-evaluation/gfr-calculators.shtmlhttp://egfrcalc.renal.org/http://www.nice.org.uk/guidance/cg182/chapter/recommendations#investigations-for-chronic-kidney-disease-2
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    AGG=H= C@==@ B==GHFM &FHFM ==, & GHG @=

    H H=@ ELHF@ I@=HM AGGGGH FJ= F F=G= KFGG H

    =@I =H = @FHFM =GH= FKFG.

    &@ @==@ =GG== FIG I@ HH H=F @@ @FHFM H @ GIF HHH=G =G =FFH =H FH=.

    2.2 U' #8! C-"!%$ %!% /& GFR

    FH= 1.1.14.

    HH=@ =H =@HH=HH=@ =H =@HH=

    EGH=HG ! (!) G GFI MGHH= C J =F G=T=HM F G==TH =GG

    IHG H HG G GFI FH==. F @ K=H FF@= =G=G,

    !MGHH=C =G =H=@ =GH= H@ HH M FI JF =G=G. G= H=G H@ M

    FGI@H = G==TH FFH= @ @GG=T G J= GH 3 CD = F@GG=T G H

    J= CD (!1A1 F !2A1). =G I@ TH H=HG @===G M FI= IGGFM

    =HHG, FI= H=HG' FG FI= H JF@@ IF CD = H

    I@H=. =G =H=@ HGH M J GH =H, IH HF K=@@ T=@ THG, K=H

    KF =GG @= H FI H GHG.

    C@@G F =@HH=C@@G F =@HH=

    CMGHH= C HGH= =G K FH= G F=FM F HG M H KF

    K H FIGH H=G HGH.

    CMGHH= C HGH= M H K=@M J=@@. &FHF=G M H =JGH = HF== ,

    = G GG, I=H.

    G= MGHH= C G =H=@ HGH K=@@ J T=@ =H. BG GH=H ,=G=G =H H IH KHF @@ @FHF=G F G=H @FHF=G

    F H=G HGH. CGHG K=@@ JFM, GI@ GGGG @@@M = H @

    FJ=G=.

    IFH F =@HH=IFH F =@HH=

    =G HGH @M G H FF = T I@H= (G F = 1.1.14)

    F@@M @M F FG.

    GGM F MGHH= C FF IG= L=GH= @MGFG.

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 36 %f 62

    http://www.labtestsonline.org.uk/understanding/analytes/gfr/tab/glance/http://www.nice.org.uk/guidance/cg182/chapter/recommendations#investigations-for-chronic-kidney-disease-2http://www.nice.org.uk/guidance/cg182/chapter/recommendations#investigations-for-chronic-kidney-disease-2http://www.nice.org.uk/guidance/cg182/chapter/recommendations#investigations-for-chronic-kidney-disease-2http://www.nice.org.uk/guidance/cg182/chapter/recommendations#investigations-for-chronic-kidney-disease-2http://www.labtestsonline.org.uk/understanding/analytes/gfr/tab/glance/
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    C@===G F @=@M H K@ H =HFIH= F IFH HGH F ! IG

    M H IH H FJ=IG@M F =GH= F=HF= F F@M CD.

    H #CE GH= GHHH F IFHF =FH= J= GHG.

    2.3 C!&8' #/# +$%8 $%!%

    FH= 1.2.1.

    HH=@ =H =@HH=HH=@ =H =@HH=

    BH @I=:FH== FH= (AC) ! ==H H F=G JFG JHG CD

    FFGG=, IH K IG HHF, F=G GHFH=TH= IFM =G =FG. F IFH

    @GG=TH= CD M @ H F HFH HFHH =HF=.

    C@@G F =@HH=C@@G F =@HH=

    GH= F H ! AC M LHF IF GH H =G=G =HF=.

    =H= AC G @GG=TH= CD F @L HG IG= CD GHG

    K=@@ H H=F FH=.

    IFH F =@HH=IFH F =@HH=

    @GG=TH= H@ GKG K H ! HF=G (!1R!5, K= J H G !

    HFG@G G H CD GHG 1R5 F FJ=IG@M), AC HF=G (A1RA3)

    GI@ =, F L@:

    A FG K=H ! 25 @/=/1.73 2

    AC 15 /@ G CD

    !4A2!4A2.

    A FG K=H ! 50 @/=/1.73 2

    AC 35 /@ G CD!3A3!3A3.

    A @F=H =G J=@@ H @ @HF FGG=@G IFGH K H HFM

    CD GI@ HF= H LH GHG F H (G @F=H B = H #CE FGIFG

    F @@ FH=).

    =G AC =G KFI@ =H FF H F=G JFG IHG = CD, H

    IG AC ! = =H= K=@@ @@K HHF F=G GHFH=TH=.

    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 37 %f 62

    http://www.nice.org.uk/guidance/cg182/resources/cg182-chronic-kidney-disease-update-costing-statementhttp://www.nice.org.uk/guidance/cg182/chapter/recommendations#classification-of-chronic-kidney-disease-2http://www.nice.org.uk/guidance/cg182/resources/cg182-chronic-kidney-disease-update-classification-tablehttp://www.nice.org.uk/guidance/cg182/resources/cg182-chronic-kidney-disease-update-guideline-algorithmshttp://www.nice.org.uk/guidance/cg182/resources/cg182-chronic-kidney-disease-update-guideline-algorithmshttp://www.nice.org.uk/guidance/cg182/resources/cg182-chronic-kidney-disease-update-classification-tablehttp://www.nice.org.uk/guidance/cg182/chapter/recommendations#classification-of-chronic-kidney-disease-2http://www.nice.org.uk/guidance/cg182/resources/cg182-chronic-kidney-disease-update-costing-statement
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    2.4 F% %/#%

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    http://www.nice.org.uk/Guidance/CG182/Resourceshttp://cks.nice.org.uk/chronic-kidney-disease-not-diabetichttp://informatica.bmj.com/solutions/clinical-decision-support-national-health-bodies/national-ckd-audit/http://www.nice.org.uk/standards-and-indicators/qofindicatorshttp://www.nice.org.uk/uptakehttp://www.nice.org.uk/uptakehttp://www.nice.org.uk/standards-and-indicators/qofindicatorshttp://informatica.bmj.com/solutions/clinical-decision-support-national-health-bodies/national-ckd-audit/http://cks.nice.org.uk/chronic-kidney-disease-not-diabetichttp://www.nice.org.uk/Guidance/CG182/Resources
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    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 42 %f 62

    http://www.nice.org.uk/Guidance/CG182/Documentshttp://www.nice.org.uk/guidance/cg182/chapter/the-guideline-development-group-national-collaborating-centre-and-nice-project-teamhttp://www.nice.org.uk/About/What-we-do/Our-Programmes/NICE-guidance/NICE-guidelines/NICE-clinical-guidelineshttp://www.nice.org.uk/About/What-we-do/Our-Programmes/NICE-guidance/NICE-guidelines/NICE-clinical-guidelineshttp://www.nice.org.uk/http://www.nice.org.uk/guidance/cg138http://www.nice.org.uk/guidance/cg76http://www.nice.org.uk/guidance/cg181http://www.nice.org.uk/guidance/cg180http://www.nice.org.uk/guidance/ta275http://www.nice.org.uk/guidance/ta275http://www.nice.org.uk/guidance/cg169http://www.nice.org.uk/guidance/cg157http://www.nice.org.uk/guidance/cg157http://www.nice.org.uk/guidance/cg169http://www.nice.org.uk/guidance/ta275http://www.nice.org.uk/guidance/ta275http://www.nice.org.uk/guidance/cg180http://www.nice.org.uk/guidance/cg181http://www.nice.org.uk/guidance/cg76http://www.nice.org.uk/guidance/cg138http://www.nice.org.uk/http://www.nice.org.uk/About/What-we-do/Our-Programmes/NICE-guidance/NICE-guidelines/NICE-clinical-guidelineshttp://www.nice.org.uk/About/What-we-do/Our-Programmes/NICE-guidance/NICE-guidelines/NICE-clinical-guidelineshttp://www.nice.org.uk/guidance/cg182/chapter/the-guideline-development-group-national-collaborating-centre-and-nice-project-teamhttp://www.nice.org.uk/Guidance/CG182/Documents
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    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 43 %f 62

    http://www.nice.org.uk/guidance/cg146http://www.nice.org.uk/guidance/ta261http://www.nice.org.uk/guidance/ta261http://www.nice.org.uk/guidance/ta256http://www.nice.org.uk/guidance/ta256http://www.nice.org.uk/guidance/ta249http://www.nice.org.uk/guidance/cg127http://www.nice.org.uk/guidance/cg125http://www.nice.org.uk/guidance/cg114http://www.nice.org.uk/guidance/cg108http://www.nice.org.uk/guidance/ph25http://www.nice.org.uk/guidance/cg91http://www.nice.org.uk/guidance/cg87http://www.nice.org.uk/guidance/ta164http://www.nice.org.uk/guidance/ta117http://www.nice.org.uk/guidance/ta117http://www.nice.org.uk/guidance/ph1http://www.nice.org.uk/guidance/cg15http://www.nice.org.uk/guidance/ta48http://www.nice.org.uk/guidance/ta48http://www.nice.org.uk/http://www.nice.org.uk/http://www.nice.org.uk/guidance/ta48http://www.nice.org.uk/guidance/ta48http://www.nice.org.uk/guidance/cg15http://www.nice.org.uk/guidance/ph1http://www.nice.org.uk/guidance/ta117http://www.nice.org.uk/guidance/ta117http://www.nice.org.uk/guidance/ta164http://www.nice.org.uk/guidance/cg87http://www.nice.org.uk/guidance/cg91http://www.nice.org.uk/guidance/ph25http://www.nice.org.uk/guidance/cg108http://www.nice.org.uk/guidance/cg114http://www.nice.org.uk/guidance/cg125http://www.nice.org.uk/guidance/cg127http://www.nice.org.uk/guidance/ta249http://www.nice.org.uk/guidance/ta256http://www.nice.org.uk/guidance/ta256http://www.nice.org.uk/guidance/ta261http://www.nice.org.uk/guidance/ta261http://www.nice.org.uk/guidance/cg146
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    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 45 %f 62

    http://www.nice.org.uk/Guidance/CG182/Evidencehttp://www.nice.org.uk/Guidance/CG182/Evidence
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    , NICE 2014. A"" &gh' &e'e&*ed. La' #%d-ed Ja$a&+ 2015 Page 49 %f 62

    http://www.nice.org.uk/Guidance/CG182/Documentshttp://www.nice.org.uk/About/What-we-do/Our-Programmes/NICE-guidance/NICE-guidelines/NICE-clinical-guidelineshttp://www.nice.org.uk/About/What-we-do/Our-Programmes/NICE-guidance/NICE-guidelines/NICE-clinical-guidelineshttp://www.nice.org.uk/About/What-we-do/Our-Programmes/NICE-guidance/NICE-guidelines/NICE-clinical-guidelineshttp://www.nice.org.uk/About/What-we-do/Our-Programmes/NICE-guidance/NICE-guidelines/NICE-clinical-guidelineshttp://www.nice.org.uk/Guidance/CG182/Documents
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    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

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    F H ==H=@ HH=

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    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

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    # @ K=H =HG

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    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

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    =HF ! = @

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    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

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    F H IFGG H=G

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    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

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    F F@ I@HFGI H @@

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    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

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    H @@K= GHG H

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    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

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    GIGH=

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    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

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    @ K=H CD = H

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    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

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    F=FM F' #CE

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    K F

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    F =HFM J= H @

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    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

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    ACE ===HF/AB HFM

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    Ch&%$c !d$e+ d'ea'e $ ad"': a''e''#e$ a$d #a$age#e$ (CG182)

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    http://www.nice.org.uk/guidance/cg182/chapter/patient-centred-carehttp://www.nice.org.uk/guidance/cg182/chapter/patient-centred-care
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  • 7/25/2019 CG182 NICE Guidance 20150309

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