ch 20 the cardiovascular system: blood vessels and circulation
TRANSCRIPT
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Ch 20
The Cardiovascular System:
Blood Vessels and Circulation
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20-1 Structure and Function of Blood
VesselsThe Largest Blood Vessels - Attach to heart
Pulmonary trunk
Carries blood from right ventricle to pulmonary circulation
Aorta
Carries blood from left ventricle to systemic circulation
Vena Cava
Carries systemic blood to right atrium.
The Smallest Blood Vessels
Capillaries - small diameter and thin walls – fluids, chemicals
and gases move across walls
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Types of Blood Vessels
Arteries -Carry blood away from heart Collaterals -Multiple arteries
that contribute to one capillary bed (Allow circulation if one artery is
blocked)
Arterioles - smallest branches of arteries
- most numerous
- exert most influence on BP
Capillaries
Are smallest blood vessels
Location of exchange between blood and interstitial fluid
Venules
Collect blood from capillaries
Veins
Return blood to heart
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Structure of Blood Vessels
Walls (except capillaries) have three layers call tunics:
Tunica intima – innermost layer- endothelium (epithelial layer –
simple squamous)
Tunica media – middle layer- smooth muscle
Tunica externa – outside layer- connective tissue
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Blood Vessels
Tunica Intima -innermost layer
The endothelial lining- simple squamous
Internal elastic membrane:
– in arteries-layer of elastic fibers in outer margin of tunica intima
Tunica Media -middle layer
Contains concentric sheets of smooth muscle in loose
connective tissue
–
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Blood Vessels
Tunica Externa -outer layer
Contains connective tissue sheath
Anchors vessel to adjacent tissues in arteries Contain collagen
Elastic fibers
In veins Contains elastic fibers
Smooth muscle cells
Vasa vasorum (“vessels of vessels”) =Small arteries and veins
In walls of large arteries and veins
Supply cells of tunica media and tunica externa
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Blood Vessels
Comparisons of a Typical Artery and a Typical Vein.
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Differences Between Arteries and Veins
Arteries and veins run side by side
Arteries have thicker walls and higher blood pressure
Collapsed artery has small, round lumen (internal
space)
Vein has a large, flat lumen
Vein lining contracts, artery lining does not
Artery lining folds
Arteries more elastic
Veins have valves
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Structure and Function of Arteries
Arteries and Pressure
Elasticity allows arteries to absorb pressure waves
that come with each heartbeat - Compliance
Contractility –smooth muscles
Arteries change diameter
Controlled by sympathetic division of ANS
Vasoconstriction:
– the contraction of arterial smooth muscle by the ANS
Vasodilatation:
– the relaxation of arterial smooth muscle
– enlarging the lumen
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Structure and Function of Arteries
Vasoconstriction and Vasodilation
Affects: Afterload on heart, Peripheral blood pressure
Capillary blood flow
Arteries -From heart to capillaries, arteries change
From elastic arteries
To muscular arteries
To arterioles
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Structure and Function of Arteries
Elastic Arteries -Also called conducting arteries
Large vessels (e.g., pulmonary trunk and aorta)
Tunica media has many elastic fibers and few muscle
cells
Elasticity evens out pulse force
Muscular Arteries - Also called distribution arteries
Are medium sized (most arteries- femoral, radial, etc)
Tunica media has many muscle cells
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Structure and Function of Arteries
Arterioles
Are small
Have little or no tunica externa
Have thin or incomplete tunica media
Small muscular arteries and arterioles
Change with sympathetic or endocrine stimulation
Constricted arteries oppose blood flow (Resistance
= R)
– resistance (R):
» resistance vessels: arterioles
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Histological Structure of Blood Vessels
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Disorders in Arteries
Aneurysm -A bulge in an arterial wall
Is caused by weak spot in elastic fibers
Pressure may rupture vessel
Atherosclerosis
Plaque within an Artery
• Disease affecting vessel wall.
• It leads to the narrowing of arteries
or complete blockage.
• Lipid deposition and inflammation
in tunic intima. (Plaque)
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Structure and Function of Capillaries
Capillaries - are smallest vessels with thin walls
Function
Location of all exchange functions of cardiovascular system
Materials diffuse between blood and interstitial fluid
Structure
Endothelial tube, inside thin
basal lamina/basement membrane
No tunica media No tunica externa
Diameter is similar to red blood cell
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Continuous Capillaries
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Types of Capillaries
Three Types
1. Continuous Capillaries -Have complete endothelial lining -
found in all tissues except epithelia and cartilage
Functions of continuous capillaries
Permit diffusion of water, small solutes, and lipid-soluble
materials
Blood cells and plasma proteins cannot leave capillaries
Specialized Continuous Capillaries - are in CNS and thymus
Have very restricted permeability
Ex, the blood–brain barrier
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Types of Capillaries
2. Fenestrated Capillaries
Have incomplete endothelial lining with pores.
Permit rapid exchange of water and larger solutes
between plasma and interstitial fluid
Are found in
Choroid plexus
Endocrine organs
Kidneys
Intestinal tract
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Types of Capillaries
3. Sinusoids (sinusoidal capillaries) Have gaps between adjacent endothelial cells
Liver
Spleen
Bone marrow
Endocrine organs
Permit free exchange
Of water and large plasma proteins
Between blood and interstitial fluid
Phagocytic cells monitor blood at sinusoids
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Capillary Beds (capillary plexus)
Connect one arteriole and one venule
Thoroughfare channels
Direct capillary connections between arterioles and venules
Controlled by smooth muscle segments (metarterioles) and
sphincters
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Contraction and relaxation cycle of capillary
sphincters -Causes blood flow in capillary
beds to constantly change routes
Capillary Beds
Pre-Capillary Sphincters
Guards entrance to each capillary
Opens and closes, causing capillary blood to flow in
pulses
Vasomotion
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Structure and Function of Veins
Veins- act as capitance vessels
Collect blood from capillaries in tissues and organs and returns blood
to heartarger in diameter than arteries
Have thinner walls than arteries that can expand/distend (capitance)
Have lower blood pressure
Compression by skeletal muscle pushes blood toward heart
=Skeletal Muscle Pump
Respiratory Pump – Breathing acts like a straw to draw blood to
heart.
Venous Valves - folds of tunica intima
Prevent blood from flowing backward
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Function of Vein Valves
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Structure and Function of Veins
Vein Categories
Venules
Very small veins
Collect blood from capillaries
Medium-sized veins
Thin tunica media and few smooth muscle cells
Tunica externa with longitudinal bundles of elastic fibers
Large veins
Have all three tunica layers
Thick tunica externa
Thin tunica media
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Distribution of Blood
Heart, arteries, and capillaries
30–35% of blood volume
Venous system
60–65%:
– 1/3 of venous blood is in
large venous networks of
liver, bone marrow, and skin
= Venous Reserve
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20-2 Blood Flow, Pressure, and
Resistance
Characteristic of a Blood Vessel
The ability to stretch- compliance
Relationship between blood volume and blood pressure
Veins stretch more than arteries
Venous Response to Blood Loss
Vasomotor centers stimulate sympathetic nerves
Systemic veins constrict (venoconstriction)
Veins in liver, skin, and lungs redistribute venous reserve
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Blood Pressure
Systolic pressure
Peak arterial pressure during ventricular contraction =
systole (120 mm Hg)
Diastolic pressure
Minimum arterial pressure during ventricular relaxation =
diastole (80 mm Hg)
Pulse pressure
Difference between systolic pressure and diastolic pressure- at
least 25% of systolic pressure
Mean arterial pressure (MAP)
MAP = diastolic pressure + 1/3 pulse pressure
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Blood Pressure
Pressures within the Systemic Circuit
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Pressure and Resistance
Force (F) = hydrostatic pressure
- Is proportional to the pressure difference (P)
divided by Resistance (R)
F= P/R
Resistance = characteristic that slows the flow of
blood – examples = viscosity of blood, turbulent
flow, vessel diameter
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Resistance
Viscosity
R caused by molecules and suspended materials in a
liquid
Whole blood viscosity is about four times that of water
Turbulence
Swirling action that disturbs smooth flow of liquid
Occurs in heart chambers and great vessels
-Atherosclerotic plaques cause abnormal turbulence
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Resistance (R) =Vascular R
Depends on vessel length and vessel diameter:- as
vessel length lengthens- R increases
– adult vessel length is constant
– vessel diameter varies by vasodilation and
vasoconstriction:
» R increases exponentially with
vasoconstriction; R= 1/r4
» so- if vessel reduces diameter by ½; R
increases 16x
» Vessel dilates to 2x diameter- blood flow
increases 16x
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Circulatory Pressure
Pressure (P)
The heart generates P to overcome resistance (R)
Absolute pressure is less important than pressure
gradient
The Pressure Gradient (P) = Circulatory pressure =
pressure gradient
-The difference between
Pressure at the heart
And pressure at peripheral capillary beds
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Circulatory Pressure and Resistance
Circulatory Pressure
∆P across the systemic circuit (about 100 mm
Hg)
Circulatory pressure must overcome total
peripheral resistance
R of entire cardiovascular system
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Circulatory Pressure
Overview of Cardiovascular Physiology
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Measuring Pressure
Blood pressure (BP) –measured with sphygmomanometer
Arterial pressure (mm Hg) -Measured as systole/ diastole
Force exerted by blood in a vessel against air in ca closed
cuff
Normal = 120/80
Hypertension -Abnormally high blood pressure:
– greater than 140/90
Hypotension -Abnormally low blood pressure
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Pulse Rate
Heart rate (HR) = heart beats/ min
Pulse rate = HR
because the increases in
blood pressure in the arteries that
lead to a noticeable pulse.
Taking the pulse is, therefore, a direct
measure of heart rate.
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Pressure in Small Arteries and
ArteriolesElastic Rebound
Arterial walls -Stretch during systole
Rebound (recoil to original shape) during diastole
Keep blood moving during diastole
Pressure and distance
MAP and pulse pressure decrease with distance
from heart
Blood pressure decreases with friction
Pulse pressure decreases due to elastic rebound
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Venous Pressure and Return
Determines the amount of blood arriving at right atrium each minute
Low effective pressure in venous system
Low venous resistance is assisted by Muscular compression of peripheral veins:
– compression of skeletal muscles pushes blood toward heart (one-way valves)
The respiratory pump:– thoracic cavity action
– inhaling decreases thoracic pressure
– exhaling raises thoracic pressure
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20-3 Capillary Pressures and Exchange
Bulk flow- mass movement of liquids (with solutes) in
and out of capillaries by pressure.
Filtration- movement out
Reabsorption – movement in
Moves materials across capillary walls by
Diffusion- Movement of ions or molecules from high
concentration to lower concentration along the
concentration gradient
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Capillary Exchange
Filtration - Driven by Capillary Hydrostatic
Pressure (CHP)
Water and small solutes
forced out through capillary
wall
Leaves larger solutes
(proteins) in bloodstream
IFHP rises only slightly-
Some fluid moves in lymph vessels
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Net Hydrostatic Pressure (NHP)
The difference between Net
Hydrostatic Pressure
and Net Colloidal Osmotic Pressure
NFP = NHP – NCOP
Difference between Capillary Hydrostatic
Pressure (CHP) and Interstitial Fluid
Hydrostatic Pressure (IFHP) -
Pushes water and solutes -out of
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Capillary Reabsorption
Reabsorption - result of osmotic pressure
differences (less water in capillaries now)
Blood colloid osmotic pressure (BCOP)
High Pressure caused by suspended blood
proteins (colloids) too large to cross capillary
walls (more concentrated with solutes)
Interstitial colloid osmotic pressure (IFCOP)
Low Pressure because fluid low in proteins
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Net Colloid Osmotic Pressure (NCOP)
The difference between
Blood Colloid Osmotic Pressure
(BCOP) and Interstitial Fluid Colloid
Osmotic Pressure (IFCOP)
NCOP = BCOP-IFCOP
*Pulls water and solutes out of IF and
into a capillary (Osmosis here!)
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Capillary Diffusion
Water, ions, and small molecules such as glucose
Diffuse between adjacent endothelial cells
Some ions (Na+, K+, Ca2+, Cl-)
Diffuse through channels in plasma membranes
Lipids and lipid-soluble materials such as O2 and CO2
Diffuse through endothelial plasma membranes
Other more porous capillaries-
Large, water-soluble compounds
Pass through fenestrated capillaries and sinusoids
Plasma proteins – large
Cross endothelial lining in sinusoids
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Net Filtration Pressure (NFP)
The difference between Net Hydrostatic Pressure
and Net Colloidal Osmotic Pressure
NFP = NHP – NCOP
Results:
Filtration = 24L/day
Reabsorption= 20.4L/day
Lymph – picks up excess
IF and returns to blood
after filtering
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Lymphatic Vessels and Capillary Beds
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Lymph Vessels and Fluid Recycling
Excess IF (from filtration) returns back into
bloodstream via the lymphoid system
Lymphatic system:
Ensure constant plasma and interstitial fluid
levels
Moves bacterial toxins and chemicals to
immune system tissues
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20-4 Homeostatic Regulation
Cardiovascular regulation changes blood
flow to a specific area
At an appropriate time- in the right area
Without changing blood pressure and blood
flow to vital organs
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Tissue Perfusion
-Blood flow through the tissues
Carries O2 and nutrients to tissues and organs
Carries CO2 and wastes away
Affected by: Blood Pressure
Blood pressure = CO x R
CO=cardiac output
R= peripheral resistance
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Regulation
Autoregulation
Causes immediate, localized homeostatic
adjustments by changes in blood flow
Neural mechanisms
Respond quickly to changes at specific sites
And
Endocrine mechanisms
Direct long-term changes
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Autoregulation of Perfusion
Adjusted by peripheral resistance while CO stays the same.
Local vasodilators:– accelerate blood flow at tissue level
» low O2 or high CO2 levels, pH (acids)
» nitric oxide (NO), high K+ or H+ concentrations
» chemicals released by inflammation (histamine)
» elevated local temperature
Local vasoconstrictors: released by damaged tissues
– examples include prostaglandins and thromboxanes
– constrict precapillary sphincters -affect a single capillary bed
Myogenic Responses: stretching of smooth muscles in
response to blood pressure
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Autoregulation
1. Neural Mechanisms -Medulla Oblongata
Cardiovascular (CV) centers
Blood Pressure Changes
– cardioacceleratory center: increases CO, blood flow
– cardioinhibitory center: reduces CO, blood flow
2. Reflex Control of Cardiovascular Function
Baroreceptor reflexes: aortic & carotid sinuses
– Stretch when blood pressure high- signals medulla oblongata
cardioinhibitory center- parasympathetic stimulation
Chemoreceptor reflexes: (located near baroreceptors)
– respond to changes in pH and dissolved gases
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Baroreceptor Reflexes
Stretch receptors in walls of
Carotid sinuses: maintain blood flow to brain
Aortic sinuses: monitor start of systemic circuit
Right atrium: monitors end of systemic circuit
-When blood pressure rises, CV centers trigger
parasympathetic stimulation at SA node
Decrease CO
Cause peripheral vasodilation
-When blood pressure falls, CV centers sympathetic
stimulation at SA node
Increase CO
Cause peripheral vasoconstriction
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Cardiovascular Regulation
Baroreceptor Reflexes of the Carotid and Aortic Sinuses
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Chemoreceptor Reflexes
Peripheral chemoreceptors in carotid bodies and
aortic bodies monitor blood for changes in:
pH, O2, and CO2 concentrations
Produced by coordinating cardiovascular and
respiratory activities
Central chemoreceptors below medulla oblongata
Monitor cerebrospinal fluid
Control respiratory function
Control blood flow to brain
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Cardiovascular Regulation
The Chemoreceptor Reflexes
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Endocrine Regulation
3. Endocrine Regulation
Hormones
Hormones have short-term and long-term
effects on cardiovascular regulation
E and NE:
from adrenal medulla stimulate CO and
peripheral vasoconstriction
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Hormones – kidney functions
Antidiuretic Hormone (ADH) ( affects kidneys)
Released by neurohypophysis (posterior lobe of
pituitary)
Elevates blood pressure
Reduces water loss at kidneys
ADH responds to
Low blood volume
High plasma osmotic concentration
Circulating angiotensin II
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Hormones
Renin-Angiotensin-Aldosterone
-cells in kidney respond to fall in renal blood pressure and
release renin (protein) into blood.
Renin-converts angiotensinogen (liver) to angiotensin I -
Angiotensin II (lungs)
Stimulates
ADH (pituitary) release, Aldosterone (adrenal cortex)
Thirst, increase Cardiac Output (CO)
Peripheral vasoconstriction
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Hormones
Erythropoietin (EPO)
Released at kidneys
Responds to low blood pressure, low O2
content in blood
Stimulates red blood cell production in red
bone marrow
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Hormones
Natriuretic Peptides-responds to high BP
Atrial natriuretic (ANP) factor (peptide)
Produced by cells in right atrium and similar peptide
(B-type) in ventricles
Respond to excessive diastolic stretching
Lowers blood volume and blood pressure
Reduces stress on heart
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Cardiovascular Adaptation to ExerciseLight exercise -Extensive vasodilation occurs:
– increasing circulation
Venous return increases -with muscle contractions
Cardiac output rises-
rise in venous return and atrial stretching
Heavy exercise - Activates sympathetic nervous system
Cardiac output increases to maximum:
– about four times resting level
Restricts blood flow to “nonessential” organs
(e.g., digestive system)
Redirects blood flow to skeletal muscles,
lungs, and heart
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Cardiovascular Adaptation to
Hemorrhaging
Entire cardiovascular system adjusts to
Maintain blood pressure
Restore blood volume
Shock
Short-term responses compensate after blood losses
of up to 20% of total blood volume
Failure to restore blood pressure results in shock
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Long-Term Restoration of Blood
Volume
Recall of fluids from interstitial spaces
Aldosterone and ADH at kidneys promote fluid
retention and reabsorption
Thirst increases
Erythropoietin stimulates red blood cell
production
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Cardiovascular Responses to
Hemorrhaging and Blood Loss
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20-5 Circulatory Pathways
Vascular Supply to Special Regions
Through organs with separate mechanisms to
control blood flow
Brain
Heart
Lungs
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Circulatory Pathways
Blood Flow to the Brain
Is top priority
Brain has high oxygen demand
When peripheral vessels constrict, cerebral vessels
dilate, normalizing blood flow
Stroke -Also called cerebrovascular accident (CVA)
Blockage (arteriosclerosis) or rupture in a cerebral
artery
Stops blood flow
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The Systemic Circuit
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Circulatory Pathways
Blood Flow to the Heart
Through coronary arteries
Oxygen demand increases with activity
Lactic acid and low O2 levels
Dilate coronary vessels
Increase coronary blood flow
Epinephrine
Dilates coronary vessels
Increases heart rate
Strengthens contractions
Heart Attack (myocardial infaction)- A blockage of
coronary blood flow
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Pulmonary and Systemic Patterns
Three General Functional Patterns
Peripheral artery and vein distribution is the same on
right and left, except near the heart
The same vessel may have different names in
different locations
Tissues and organs usually have multiple arteries and
veins
Vessels may be interconnected with anastomoses
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The Pulmonary Circuit
1. Deoxygenated blood arrives at heart from
systemic circuit:
Passes through right atrium and right ventricle
Enters pulmonary trunk
2. At the lungs:
CO2 is removed
O2 is added
3. Oxygenated blood:
Returns to the heart
Is distributed to systemic circuit
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The Pulmonary Circuit
Pulmonary Vessels
Pulmonary arteries
Carry deoxygenated blood
Pulmonary trunk:
– branches to left and right pulmonary arteries
Pulmonary arteries:
– branch into pulmonary arterioles
Pulmonary arterioles:
– branch into capillary networks that surround alveoli
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The Pulmonary Circuit
Pulmonary Vessels
Pulmonary veins
Carry oxygenated blood
Capillary networks around alveoli:
– join to form venules
Venules:
– join to form four pulmonary veins
Pulmonary veins:
– empty into left atrium
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The Pulmonary Circuit
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The Systemic Circuit
Contains 84% of blood volume
Supplies entire body
Except for pulmonary circuit
Systemic Arteries
Blood moves from left ventricle
Into ascending aorta
Coronary arteries
Branch from aortic sinus
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The Systemic Circuit
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The Systemic Circuit
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Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings
The Systemic Circuit
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The Systemic Circuit
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The Systemic Circuit
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The Systemic Circuit
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The Systemic Veins
Complementary Arteries and Veins
Run side by side
Branching patterns of peripheral veins are more variable
In neck and limbs
One set of arteries (deep)
Two sets of veins (one deep, one superficial)
Venous system controls body temperature
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The Systemic Veins
Cerebral Veins – most veins go deep into cerebral
sinuses- ultimately through jugular foramen to
internal jugular vein (parallel to carotid)
internal jugular -Empties into brachiocephalic veins
of chest
brachiocephalic to superior vena cava
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The Systemic Circuit
.
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The Systemic Circuit
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The Systemic Circuit
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Blood Processed in Liver
After processing in liver sinusoids (exchange
vessels), blood collects in hepatic veins and
empties into inferior vena cava
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The Systemic Circuit
The Systemic Circuit
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20-6 Development and Fetal/ Maternal
Circulation Embryonic lungs and digestive tract nonfunctional
Respiratory functions and nutrition provided by placenta
Placental Blood Supply
Blood flows to the placenta
Through a pair of umbilical arteries
Which arise from internal iliac arteries
And enter umbilical cord
Blood returns from placenta
In a single umbilical vein
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Fetal and Maternal Circulation
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Aging and the Cardiovascular System
Cardiovascular capabilities decline with age
Age-related changes occur in
Blood
Heart
Blood vessels
Three Age-Related Changes in Blood
Decreased hematocrit
Peripheral blockage by blood clot (thrombus)
Pooling of blood in legs - due to venous valve deterioration
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Aging and the Cardiovascular System
Three Age-Related Changes in Blood Vessels
Arteries become less elastic
Pressure change can cause aneurysm
Calcium deposits on vessel walls
Can cause stroke or infarction
Thrombi can form
As atherosclerotic plaques