goutchapter 1 : gout basics is where you’ll discover everything about gout: what it is, risk...
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GOUT RESCUE “HOW TO GET RELIEF FROM YOUR GOUT IN HOURS, NOT
DAYS OR WEEKS, AND HOW TO PREVENT IT DESTROYING
YOUR LIFE (QUITE LITERALLY!)”
AUTHOR: JOHN CIELO
Copyright © 2016
All rights reserved worldwide.
No part of this publication may be replicated, redistributed or given away in any
form whatsoever without the prior consent in writing of the author or publisher.
Disclaimer
The content of this book is for informational purposes only. It is not intended to be a substitute for proper medical diagnosis, treatment, or advice, and you should not
assume that it is, or use it as such. Always consult with your health-care provider before taking any medications, natural remedies, supplements, or making any major changes to your diet.
Table of Contents
Gout and Me
How to Get the Most Out of This Guide
Did You Know?
Chapter 1: Gout Basics
Who is Most at Risk of Gout?
Common Gout Myths
Root Cause of Gout
How Long Does a Gout Attack Last?
Is it Gout or Pseudogout?
How Gout is Diagnosed
Gout Has 4 Stages: Which Stage Are You At?
Serious Health Risks Associated with Gout
Gout Can Also Be a Sign of an Underlying Health Problem
So Are You Taking Your Condition Seriously Enough?
Chapter 2: Treatment
How Gout is Treated Today
Your First Diagnosis
Already Got Gout?
Chapter 3: Using Diet to Help Manage Your Gout
Reduce the Purines in Your Diet
Avoid Sugar in Your Diet
Eat More Alkalizing Foods
Reduce Your Salt Intake
The DASH Diet
Chapter 4: What Does a Gout Diet Look Like?
Protein
Complex Carbohydrates
Essential Fatty Acids
Fiber
Vitamins and Minerals
Antioxidants
Chapter 5: Lifestyle Adjustments to Prevent Gout Flares
Avoid Alcohol
Keep Yourself Properly Hydrated
Lose Some Weight
Avoid High Protein Weight-Loss Diets
Exercise
Reduce Stress
Chapter 6: Liver and Kidney Health
Liver
Kidneys
Tips for a Healthy Liver and Kidneys
Chapter 7: Complementary and Alternative Medicine
Acupuncture
Acupressure
Ayurveda
Homeopathy
Mineral Tissue Salts
Hydrotherapy
Herbal Medicine
Dietary Supplements
Home Remedies
Chapter 8: My Top 3 Remedies for Fast Gout Relief
Chapter 9: Putting It All Together – Your Checklist
Chapter 10: Summary
Appendix A: Purine Tables
Completely Avoid These High Purine Foods
Limit These Moderately High Purine Foods
Enjoy These Low Purine Foods
Appendix B: Example Meals
Breakfasts
Light Meals
Mains
Desserts
Snacks
Appendix C: Resources
United States
United Kingdom
Canada
Australia
New Zealand
Forums
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Gout and Me I’ve had gout most of my adult life but haven’t had a
gout flare for many years now; well over 7 years at the
time of writing this guide. But I used to get multiple
attacks every year; so what changed? What brought
about this ‘miracle?’
The trigger was a conversation I had with my brother-in-
law, all those years ago. In that life-changing conversation he told me he had just
been diagnosed with gout and had started researching into it.
The stuff he had uncovered was, at the same time, both alarming and encouraging.
Alarming, because I hadn’t really appreciated just how serious and debilitating the
condition could be. Encouraging, because there was so much that could be done to
manage it successfully.
So as a long-time gout sufferer, and taking my brother-in-law’s lead, I set about
doing my own, even more in-depth, research. It became a real passion. So much so,
I have written and published several hundred articles on the subject over the years.
And here’s what I’ve discovered: a gout-free life is possible and I’m living it!
Don’t worry, if you wish to use a totally natural drug-free approach, a combination of
medication and natural treatments, or just medication, this guide has you covered.
However, whichever route you take, it isn’t enough just to get rid of the symptoms;
you must prevent recurring gout from seriously damaging your health and putting
you at a higher risk of premature death. Yes, you read that right!
Now, if you’ve had multiple flare-ups, some of what I share might seem irrelevant,
but I firmly believe that the myths, conflicting information, and misinformation I’d
been given over the years was one of the main reasons for my frequent attacks.
That’s why I’m sharing with you what I’ve researched and learned over the years.
Therefore, whether this is your first gout attack, or you’ve had multiple flare-ups,
this book might just help you to beat your gout too.
To your good health!
John Cielo
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How to Get the Most Out of This Guide
First things first; if you’re having a gout flare-up right now then go straight to
Chapter 8 where you’ll discover my top 3 remedies for quickly relieving a gout
attack.
Otherwise, make sure you take a look at:
Chapter 1 : Gout Basics is where you’ll discover everything about gout: what it is,
risk factors, what causes it, the symptoms, how it’s diagnosed, the 4 stages of gout,
and the very serious health conditions associated with it.
*Don’t skip this chapter because a deeper knowledge of the condition will lead to a
much better understanding of how the drug-based and alternative therapies detailed
in this book can help manage your condition and prevent future flare-ups.
Chapter 2: Treatment is where you’ll learn how gout is treated today using drug
therapy, including those for relieving the symptoms of a gout flare and those for
managing the condition long term. It also lists potential side effects.
Chapter 3: Using Diet to Help Manage Your Gout concentrates on the link
between diet and gout; in particular how many foods are high in a natural chemical
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that, when metabolized, can lead to gout. Here, you’ll learn how to use diet to help
manage your condition effectively.
Chapter 4: What Does a Gout Diet Look Like? goes into more detail about what
constitutes a varied, well-balanced, healthy gout diet to meet the twin objectives of
successful gout management and overall health and wellness.
It includes important information on essential vitamins and minerals you need, and
which foods are the best at providing them.
Chapter 5: Lifestyle Adjustments to Prevent Gout Flares describes several
lifestyle changes you must make in addition to your new gout diet, which, if not
undertaken, can pose a serious risk to your ability to manage your condition
successfully and stay free from gout flare-ups.
Chapter 6: Liver and Kidney Health discusses the importance of a healthy liver
and kidneys in controlling your gout and lists critical actions for preventing damage
and disease.
Chapter 7: Complementary and Alternative Medicine is where you’ll discover
how complementary medicine, alternative treatments, herbal remedies, dietary
supplementation, and natural home remedies can all help to relieve gout and
prevent future attacks.
Chapter 8: My Top 3 Remedies for Fast Gout Relief is where I’ve listed my top
3 natural remedies for getting gout relief in hours, rather than in days or weeks.
Chapter 9: Putting It All Together pulls together all the foregoing and displays it
as a “checklist” that, if followed, will help you manage your gout and reduce the risk
of further gout flares.
Chapter 10: Conclusion summarizes the key points and hammers home the
importance of not ignoring your gout, particularly with the threat of some very
serious health consequences hanging over your head if you do so.
Appendix A: Purine Tables classifies some common foods by high, moderate, and
low purine content.
Appendix B: Example Meals contains some example meals for breakfast, lunch,
dinner, desserts, and snacks.
Appendix C: Resources lists some useful resources by country.
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Did You Know…?
The term ‘gout’ comes from the Latin word ‘gutta’ meaning ‘drop.’
It has been around for thousands of years - it’s believed that the Egyptians
were the first to identify gout and there is evidence of the condition in
mummies.
In the 5th century BC, the great Hippocrates, referred to it as the ‘un-
walkable disease.’
Gout affects nearly 6% of men and 2% of women in the U.S. according to a
2011 study published in Arthritis & Rheumatism.
It affects nearly 7% of men and 3% of women in the U.K., according to the
UK Gout Society.
That’s equivalent to over 8.3 million adults in the U.S. and 3.2 million in the
U.K.
In addition, it’s increasing year on year…the incidence of gout in the U.S.
doubled between 1961 and 2011 and by 64% in the U.K. between 1997 and
2012.
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Chapter 1: Gout Basics
Who is Most at Risk of Gout?
There are quite a number of high risk factors for developing gout. People at a higher
risk of gout:
are male, typically between the ages of 30 and 50 for the onset of gout.
females, but more usually over 50s / after the menopause.
have a family history of gout or arthritis (genetics – see note below).
are overweight.
have a high-purine diet (lots of red meat, organ meat, poultry, seafood).
consume too much sugar (fructose).
drink too much alcohol and/or smoke.
have existing medical conditions such as, acidosis (increased acidity in the
blood and body tissue), diabetes, arteriosclerosis (hardening of the arteries),
hypertension (high blood pressure), thyroid problems, and hyperlipidemia
(increased levels of lipids in the blood).
have had surgery or prolonged bed rest including have had an organ
transplant.
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are on certain medicines such as, diuretics, niacin (vitamin), salicylic acid (e.g.
aspirin), levodopa, and cyclosporine.
have had a joint injury, particularly in the foot.
have had long-term exposure to lead over and above that arising from normal
community exposure.
Note: Scientists have identified several genetic mutations that contribute to a higher
risk of gout, their presence varying across race. For example, according to scientists
at John Hopkins, one particular mutation (the ABCG2 Q141K mutation) affects 10%
of Caucasians, 3% African-Americans, and 31% of Asians.
Common Gout Myths
Here are common gout myths that, if you believe them, will NEVER get you the
results you want:
Gout is all about genetics - nothing to do with lifestyle or diet.
Not so. You’re at a higher risk of gout if it’s in the family, sure, but the majority of
gout sufferers don’t have any family history of gout. Look at the John Hopkins’
figures above!
Gout is curable.
No. Gout cannot be cured...once you have gout you have it for life. However, it can
be managed, and that means keeping your blood uric acid at healthy levels, which is
what you’ll learn about in this guide.
Only men get gout.
Wrong. Women get gout too, but ten times more men than women get gout.
However, women’s risk of gout increases markedly after the menopause.
Only wealthy people have gout.
Wrong. Certainly, in older times, it was common among royal and wealthy people,
largely due to the copious amount of meat and drink they consumed.
But poorer people could also suffer with it: for example, gout was fairly common
among Roman soldiers.
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And today, irrespective of social status, anybody can have gout, with many people
completely unaware that gout could be the cause of their joint pain.
Gout only appears in the big toe.
Wrong. Although the metatarsophalangeal joint at the base of the big toe is the
most common place for gout (60-70% of incidences), it can, and frequently does,
flare-up in any joint including the heel, side of the foot, ankle, knee, fingers, wrist,
and elbow.
I can prevent gout just by changing my diet
No. Diet is an important element in helping to manage your gout, that’s true, but it's
not the only one. You also need to consider things like your weight, drinking habits,
any medications you are on, other medical conditions you may have, your age, sex,
and even your family history.
I can prevent gout just by relying on medication.
Not so. Medication can manage your uric acid, for sure, but it cannot help the
underlying triggers for gout such as being overweight, drinking too much alcohol
and eating an unhealthy diet. Medication is only one aspect of the solution.
Furthermore, it’s worse for first-time gout victims: many folks having their first gout
attack, unaware that it could be gout, don’t even bother seeking medical attention
and treat it at home with painkillers or anti-inflammatories.
Gout’s painful but it isn’t serious and never dangerous.
Wrong. If gout isn’t managed properly high blood uric acid and frequently recurring
gout flares can lead to some serious health problems including permanent joint
damage, kidney and liver disease, hypertension, diabetes, stroke, heart disease, and
a higher risk of premature death.
I have high uric acid, but as long as I'm not having any gout flare-ups, I'm O.K.
No. Even without having flares, the high uric acid in your blood can still be putting
you at a higher risk of those serious health issues.
Root Cause of Gout
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The root cause of gout is too-high levels of uric acid in the blood. This is a condition
called ‘hyperuricemia’, which, if not addressed, can lead to the formation of
microscopic needle-shaped crystals (monosodium urate) in the joints, tendons, and
surrounding tissue.
The body’s innate immune system recognizes these crystals as potentially harmful
and triggers a response that floods the joint with white blood cells and inflammatory
mediators to resist and eventually expel the ‘intruders.’
Note: It’s this inflammatory response at the site that actually causes the painful
symptoms we associate with a gout attack, NOT the actual crystals themselves.
There are two scenarios that can lead to hyperuricemia:
The kidneys, for one reason or another, are not processing and excreting
enough uric acid quickly enough: under-excretion.
The body is producing too much uric acid for the kidneys to process even
though they are working efficiently: overproduction.
But, many people with high blood uric acid may never actually experience a gout
attack in their lifetimes. It is not known exactly why someone with high uric acid
should suddenly experience a gout flare and someone else, with similar high uric
acid, can go through life without one.
However, studies have identified certain high risk ‘triggers’ for gout attacks in people
with high blood uric acid. These are:
drinking too much alcohol (particularly beer).
being overweight.
consuming too much high-purine food.
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certain medicines (particularly aspirin, diuretics and niacin).
some medical conditions (e.g. high blood pressure, diabetes, acidosis, high fat
and cholesterol, chemotherapy, surgery, extended bed rest).
rapid weight-loss (e.g. through illness, crash dieting).
long-term stress.
Once having had a gout attack you have gout for life. There is no known cure.
However, you can manage it, so that you can stay clear of future gout flares.
The key is to reduce your blood uric acid, maintain it at healthy levels, and correct /
manage / eliminate those attack triggers under your control, for example, diet,
weight, alcohol, blood pressure, cholesterol, acidosis, and stress.
Okay, the next section describes how uric acid is manufactured in your body. By
being better informed of the process you’ll be in a better position to understand the
way in which drugs, natural remedies, and specific lifestyle changes work to first
lower, then maintain, your uric acid at healthy levels.
Where Does Uric Acid Come From?
Purines
Uric acid is a natural byproduct of the metabolic breakdown of organic compounds
called ‘purines.’
These exist naturally in our bodies’ cells, in animals’ cells, and in the cells of the food
we eat at varying concentrations.
Generally speaking, the highest concentrations of purines are to be found in high
protein foods such as red meat, organ meat (offal), game, poultry, fish and shellfish.
Purines are extremely important; they are a part of the building blocks of our DNA
(deoxyribonucleic acid) and are needed to help synthesize RNA (ribonucleic acid) for
proteins.
DNA contains the ‘instructions’ that make each of us unique – our genetic
information - and is passed from adult to child, generation to generation.
RNA produces all the proteins in our cells: proteins being required for the proper
structure, function and regulation of our bodies’ tissues and organs.
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When cells breakdown and die, the purines in their genetic material also breakdown,
forming uric acid in the process. This happens with our own bodies’ cells and the
cells of food.
It’s believed that around 70% of uric acid in the body comes from purines in our
body’s cells with the other 30% coming from purines in the food we eat. Therefore,
the amount produced via food is significant enough not to be ignored.
The actual process is that the liver metabolizes (breaks down / changes) the purines
into uric acid which is released into the bloodstream, is filtered by the kidneys, and
then excreted in urine.
This process maintains blood uric acid at healthy levels. This is very important,
because we need some uric acid in our system, as it’s one of the body’s most potent
antioxidants. Antioxidants neutralize and remove free radicals that cause many
illnesses and chronic diseases, including cancers.
But, as discussed previously, when there is under-excretion or overproduction of uric
acid, excess acid will build up in the bloodstream, which can then lead to
hyperuricemia and gout.
Fructose
Another cause of increased uric acid is too much fructose consumption.
Fructose is found in table sugar and a whole array of processed foods and drinks,
often in the form of High Fructose Corn Syrup (HFCS), which is manufactured out of
corn starch.
Over the last 30 years or so, HFCS has replaced sugar as the sweetener of choice in
soft drinks, being around 1.6 times sweeter than sugar.
Fructose can also be found, naturally, in some fruits and vegetables, but in lower
concentrations.
Fructose is not a purine, but when too much fructose is ingested, it can raise uric
acid levels in several ways:
When fructose breaks down, it produces lactic acid. Studies have found a link
between increased lactic acid and a decrease in uric acid excretion.
Too much fructose can lead to insulin resistance, which is linked to decreased
uric acid excretion.
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It has been discovered that when the liver has to deal with too much
fructose, it results in elevated uric acid.
Fructose increases the breakdown of ATP (adenosine triphosphate), a
molecule in the body, which is the primary source of energy for the cells. It is
also a purine so, as it breaks down, even more uric acid is produced.
Don’t forget that too much sugar causes weight gain and we know that being
overweight is one of the highest risk factors for gout.
And, it’s interesting to note, that an increasing number of medical professionals now
identify sugar as a potentially higher risk factor for gout than purines in
food.
What Are Safe levels of Uric Acid?
Not everyone with high uric acid will get gout. On the other hand, not everyone with
low levels of uric acid will escape gout either.
The reasons for this anomaly are not yet known, but it is generally agreed that a
person with high uric acid is at a significantly higher risk of gout than someone with
low levels of uric acid.
The key is to get blood uric acid levels down below the saturation point at which
urate crystals form, and maintain those levels.
According to the American College of Rheumatology, the target is to have a serum
uric acid level less than 6 milligrams per deciliter (6 mg/dL).
The University of Rochester Medical Center has a slightly different measure: they
allow a maximum of 7 mg/dL for males and 6 mg/dL for females.
But, it's generally assumed that 'high uric acid' is anything over 6 mg/dL.
However, some people can have levels over 9.0 mg/dL and still not suffer from gout
attacks. Equally, gout is found in patients with levels under 6 mg/dL.
Much depends on the individual. But, as a general rule of thumb, maintaining your
levels below 6 mg/dL is a good target.
The fact is that different laboratories and health authorities around the world use
different reference points and units of measurement. Your doctor will advise you on
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what your results mean to you, whilst taking into account your health position at the
time.
Gout Attacks Are More Common at Night
A recent study has proved what gout sufferers have known all along: gout attacks
are more common at night.
The study, published in the American College of Rheumatology journal Arthritis &
Rheumatology concluded that the risk of gout attacks during the night and early
morning is 2.4 times higher than in the daytime.
One reason given is that body temperature naturally falls during sleep, particularly in
the feet. These lower temperatures reduce the solubility of uric acid in the blood,
making it easier for urate crystals to form out of the uric acid.
However, there is now another possibility, and that is the presence of ‘sleep apnea.’
Recent studies have established a possible link between sleep apnea and gout.
Sleep Apnea
Sleep apnea (spelled “apnoea” in some countries) is a condition in which the
sleeper's airway is blocked for short periods so that no air gets to their lungs. This
can last for seconds to a minute or more, and can happen hundreds of times during
the night.
Oxygen starvation builds-up with each apnea, which increases cell degradation
leading to even more uric acid production. And, as the blood becomes more acidic
due to reduced oxygen with each apnea, it's easier for uric acid crystals to form,
resulting in a gout flare.
Sleep apnea is a serious condition with numerous other complications such as
fatigue, memory loss, hypertension, obesity, diabetes, stroke, heart failure, and
several others.
Many people are completely unaware that they have sleep apnea so the presence of
gout (high uric acid) could be a sign that they have it. Someone with recurring gout
might well consider speaking to his or her doctor about being tested for sleep apnea.
How Long Does a Gout Attack Last?
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An attack of gout can last anywhere from 3 to 21 days, sometimes even longer. 7 to
10 days could be the average for most people.
But a lot depends on its location in the body, how quickly it is diagnosed, how
quickly treatment is started, and the type of treatment used.
However, there are other determinants for how long a gout attack can last. For
example, gout may last longer in patients who:
are overweight.
consume high-purine diets.
drink alcohol to excess.
are stressed.
have certain underlying medical conditions.
are taking certain medications.
Do these seem familiar? They should be. They are the high-risk triggers for gout
attacks, discussed previously. Therefore, not only do they raise the risk of an actual
attack in someone with high uric acid, they also raise the risk of prolonging it.
You will know yourself if you fall into any of these categories. The first four are
completely under your control; the other two you need to speak to your doctor
about.
Is it Gout or Pseudogout?
Pseudogout -- calcium pyrophosphate dehydrate crystal deposition disease (CPDD) --
is a disease that can cause arthritic attacks whose symptoms are very similar to
gout: sudden intense joint pain, redness, tenderness, stiffness, warmth, and
swelling.
Like gout, crystals in the joints cause it, but unlike gout, the crystals are made from
an insoluble calcium salt called “calcium pyrophosphate dehydrate.” Because of the
similarity of symptoms, CPDD is often misdiagnosed as gout.
Therefore, it’s important to get a professional diagnosis to determine which disease
is present because, apart from the use of non-steroidal anti-inflammatory drugs
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(NSAIDs) and perhaps steroids to reduce inflammation, the treatment for each
condition is different.
With pseudogout, treatment is essentially about ongoing inflammation and pain
management. Pseudogout crystals cannot be dissolved. But, if they continue to be a
problem, they may be removed physically along with synovial fluid through needle
aspiration.
With gout, however, treatment can help to dissolve uric acid crystals and reduce
blood uric acid levels to prevent further crystal formation and flares.
How Gout is Diagnosed
Your doctor will usually ask about your symptoms, when they first appeared, and
inspect the physical signs. Even although the symptoms could indicate gout, they
will want to first rule out any other possible causes by asking pertinent questions
and may even arrange for an x-ray.
They may also want to quiz you on any sudden change of diet - which can elevate
uric acid levels - and any medications you may be taking.
They should also ask about any family history of arthritis and / or gout, if they don’t
already have that information on record.
Some may seek confirmation through a blood test to measure uric acid serum
concentration. However, uric acid levels can go down during a gout attack (nobody
really knows why) so a blood test can be unreliable at this time.
A much safer test is for synovial fluid to be drawn-off and examined under the
microscope in polarized light for evidence of yellow, needle-shaped, gout crystals.
Pseudogout will show up as blue, rhomboid-shaped, crystals under polarized light.
This test can also help to rule out bacterial infection as a potential cause of the
symptoms.
A 2014 study by the Mayo Clinic has shown that the most accurate test for some
patients is a CT scan. However, the study author, Dr. Tim Bongartz, said it should
only be used where the patient has had several attacks (of what looks like gout), but
needle aspirations had shown up negative.
Interestingly, while the CT scan was more accurate in multiple attacks, the study
showed that the synovial fluid test is effective in most cases and was actually more
accurate in identifying first-time (new onset) gout flares.
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Gout Has 4 Stages: Which Stage Are You At?
Gout progresses through four stages, each with its own symptoms, or indeed, lack
of any signs or symptoms. As the disease progresses, each stage is more painful and
more debilitating, until in the last stage things get very serious.
1. Asymptomatic Hyperuricemia
In this first stage, a sufferer will have high blood uric acid levels. However, there will
be no signs or symptoms, so that the person is usually unaware that they have the
condition.
They will continue with their normal lifestyle unaware that that lifestyle could be
raising uric acid levels even further. It’s usually near the end of this stage that urate
crystals start to form.
2. Acute Gout
The start of this stage is the sudden onset of the first gout attack and its associated
painful symptoms caused by the build-up of crystals of urate in the joints and
surrounding tissue. Further attacks will occur during this stage. And, as the disease
progresses, these flares will usually occur more frequently and last longer.
3. Interval or Intercritical Gout
This can be misleading for many gout sufferers. This stage defines the intervals
between each gout flare where there are no symptoms and the joints are back to
normal or, at least, appear to be.
This can lead to sufferers forgetting that they have the condition and perhaps
believing that they are ‘cured.’ The problem is that they then stop taking their
medication and lapse back into their previous lifestyle, which raises the risk of
another gout attack.
4. Chronic Tophaceous Gout
This is the final and most debilitating stage. It’s during this stage that serious
complications can arise such as permanent joint damage, kidney disease, kidney
stones, heart disease, stroke, and even a higher risk of premature death.
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In this stage, uric acid crystals come together to form a small lump (tophus) in soft
tissue, cartilage and bone around the body. Under the skin, they look white or
yellowish-white.
Although most commonly found in the fingers, toes, heels, ankles, elbows and ears,
tophi (plural) may be found in any area of the body. They have even been known to
appear, albeit very rarely, in the vocal cords and spinal column.
There usually isn’t pain with small tophi. However, as they grow bigger - as more
and more crystals cluster together - the patient will feel pain and discomfort,
especially with tophi in, and around, joints.
The only solution is to reduce uric acid levels below the saturation point for crystal
formation. This prevents new crystals forming and so stops any more tophi growth.
The existing crystals are then able to slowly dissolve and shrink the tophi ‘lumps’ in
the process. In many cases, if caught early enough, they should disappear
altogether.
However, if not properly treated, tophi lumps can grow to an enormous size, occur
in multiple locations, and be extremely unsightly and debilitating. At this point,
surgery may be required to remove the tophi and even to repair or replace any
permanently damaged tophi joints.
So, as a gout sufferer, it’s vital to keep your uric acid levels below saturation point in
order to inhibit urate crystal formation. And, at the very first sign of tophi, however
small, address the problem right away, as tophi are a sure sign of too high uric acid.
Serious Health Risks Associated with Gout
It has been known for some time that frequently recurring gout can cause
permanent joint damage and kidney stones. However, more recently, a stream of
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studies have associated high blood uric acid with other serious health problems,
including a higher risk of premature death:
A recent University of Maryland study linked high uric acid to kidney disease,
kidney failure, diabetes, stroke, heart disease and an increased risk of death.
In 1997, researchers at the University of Kuopio, Finland, linked high levels of
uric acid to an increased risk of non-fatal and fatal stroke.
In the same year, researchers at John Hopkins linked high uric acid to mini
strokes that, although hardly noticeable, could lead to mental decline in aging
adults.
A 2013 study by University of Limerick researchers found that, compared to
individuals without gout, people with gout died earlier and had a 42% higher
risk of death. In addition, people with gout had a 58% higher risk of dying
from cardiovascular disease.
The Limerick study also showed that raised uric acid levels were even
detrimental to people who had otherwise healthy lifestyles, i.e. were
physically active, did not smoke, and didn’t drink.
A 2015 Chinese study by Weijie Wang and colleagues linked gout to a higher
risk of cancer, particularly that of urological cancers, digestive system
cancers, and lung cancer.
Another 2015 Chinese study by Dandan Yan, Yinfang Tu, and colleagues
identified an association between elevated blood uric acid and an increased
risk of diabetic kidney disease.
In 2016, Dr. Yasuhiko Kubota (School of Public Health, University of
Minnesota) and colleagues established a link between high blood uric acid and
an increased risk of Venous Thromboembolism (VTE).
A 2010 study by Dr. Anita Afzali (Senior Fellow, Dept. of Medicine,
Gastroenterology, at the School of Medicine, University of Washington) and
colleagues linked elevated blood uric acid to an increased risk of chronic liver
disease.
And, data from a 2013 study in China by Yuanliang Xie and colleagues
suggested that elevated blood uric acid was associated with non-alcoholic
fatty liver disease (NAFLD).
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A 2016 study by Taiwanese researchers associated gout with a higher risk of
hip fractures compared with not having gout, especially in women.
In summary, then, studies have associated gout with a higher risk of:
kidney disease
kidney failure
liver disease
hip fractures
new-onset diabetes
diabetic kidney disease
fatal and non-fatal stroke
cardiovascular disease
cardiovascular death
venous thromboembolism – blood clots in the vein
cancers – especially urological, digestive system, and lung cancers
early death
So, it’s vital to do everything in your power to keep your uric acid at healthy levels,
to prevent recurring gout flare-ups and to reduce the risk of some extremely serious,
and potentially fatal, conditions.
Gout Can Also Be a Sign of an Underlying Health Problem
Gout is also commonly associated with a number of other diseases and conditions:
Metabolic Syndrome
Nearly 75% of gout patients exhibit metabolic syndrome; the medical term for a
group of conditions associated with the development of cardiovascular disease (i.e.
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coronary heart disease, heart attack, congenital heart disease, angina, and stroke)
and type 2 diabetes.
This metabolic ‘group’ includes abdominal obesity, hypertension, insulin resistance,
and abnormal lipid levels. And, although you can have any one of these on its own,
patients will very often have them together, which greatly increases the risk of
cardiovascular disease and type 2 diabetes.
The main causes of metabolic syndrome are being overweight, physically inactive,
and having inherited a genetic tendency to develop insulin resistance.
Other Conditions
Other conditions associated with gout include:
lead poisoning
polycythemia (high red blood cell count)
hemolytic anemia (high red blood cell destruction rates)
peripheral vascular disease (poor circulation in the limbs)
psoriasis (a chronic skin condition)
kidney disease
erectile dysfunction (ED)
So a formal diagnosis of gout may be the first sign of an otherwise unknown medical
problem. In other words, the presence of gout could be a symptom of an underlying
medical issue.
Which is why, if you suspect you have gout, seek expert medical help at the earliest
opportunity. In fact, some experts suggest that, when diagnosed with gout, patients
should be tested for known associated diseases and conditions.
You should note that the link between metabolic syndrome and cardiovascular
disease and diabetes is independent of the link between high uric acid
(hyperuricemia) and the risk of those same conditions.
This fact is important because many gout patients rely on their medications alone to
manage their uric acid levels, ignoring the underlying triggers for gout: being
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overweight, an inactive lifestyle, an unhealthy diet, stress, and drinking too much
alcohol.
So, although they may be free from actual gout flare-ups, by ignoring those
underlying issues they are putting themselves at a higher risk of cardiovascular
disease, type 2 diabetes, and other conditions and diseases associated with gout.
So Are You Taking Your Condition Seriously Enough?
Too many gout sufferers just concentrate on eliminating the excruciating pain of a
gout flare then, once the attack has abated, completely forget about it assuming, or
rather, hoping against hope, that it won’t come back. But, it’s highly likely that it
will; once you have gout, you have it for life.
In the words of Dr. Larry Edwards, a Specialist in Internal Medicine and
Rheumatology at the University of Florida School of Medicine: “It’s important to
remember that once you have gout you have it for life, not just when you’re having
symptoms of an acute attack. That’s why you should educate yourself about it. This
will help you take steps to prevent it from progressing and minimize the chances of
an attack.”
So, even between gout flares, you’ve still got gout. The fact that you’re going about
your daily life, symptom-free, doesn’t mean that you’re cured of gout. You are not.
However, the good news is you can definitely manage your condition so that you
stay free from further attacks. And, by not relying on medicines alone, you can
reduce the risk of those serious diseases and conditions associated with gout.
The following chapters set out how you can do this...
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Chapter 2: Treatment
How Gout is Treated Today
Gout is treated using medication: one type to help relieve the pain and
inflammation, and another to help lower and maintain uric acid levels. Your doctor
should also advise on dietary and lifestyle changes you should make.
Pain and Inflammation
For pain and inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) such as
ibuprofen, naproxen, indomethacin, and diclofenac can be effective.
Where a patient cannot take NSAIDs, or where they have been found to be
ineffective, then colchicine may be prescribed instead. Colchicine is not a painkiller
as such, but rather, helps to relieve pain by reducing the white blood cell count in
the inflamed area.
And, in the situation where a patient cannot take NSAIDs or colchicines, then
corticosteroids, such as prednisone, can be prescribed. These are administered orally
or by injection into the affected area.
Note: Low-Dose Aspirin
Aspirin is a NSAID and, as such, would seem to be a perfect, low cost solution for a
gout flare. However, aspirin has certain characteristics that make it unsuitable for
treating the inflammation and pain of a gout attack.
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It’s known that aspirin can increase uric acid levels by reducing the kidneys’ ability to
excrete uric acid. Therefore, taking aspirin at the onset of, or during, a gout attack
will only exacerbate the symptoms. So, doctors don’t recommended aspirin for gout.
But, there are many people who take low-dose aspirin to help reduce the risk of
heart disease and stroke. What happens if they also suffer from gout?
According to a study published in PubMed.gov in February 2014, those on such low-
dose aspirin, and who have gout, are at a higher risk of recurring attacks.
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