135

CHAPTER 7

REFERENCES

136

Adelroth E, Rosenhall L, Johansson 5, Linden M, Venge P. (1990) Inflammatory cells

and eosinophilic activity iii asthmatics invest tigated by bronchoalveolar lavage: the

effects of antiasthmatic treatment with budesonide or terbutaline. Am Rev Respir Dis;

142:91-99.

Adler KB, Holden-Stauffer WJ, Repine JE. (1990) Oxygen metabolites stimulate release

of high molecular weight glycoconjugates by cell and organ cultures of rodent respiratory

epithelium via arachidonic acid dependent mechanism. J Clin Invest.85: 75–85.

Amayasu H, Nakabayashi M, Akahori K, Ishizaki Y, Shoji T, Nakagawa H, Hasegawa H,

Yoshida S. (2001) Cromolyn sodium suppresses eosinophilic inflammation in patients

with aspirin-intolerant asthma. Ann Allergy Asthma Immunol; 87:146–50.

Amighi K., Pilcer, G., Vanderbist, F., (2008) Correlations between cascade impactor

analysis and laser diffraction techniques for the determination of the particle size of

aerosolised powder formulations. Int. J. Pharm. 358, 75–81.

Amin, A. H., Mehta, D. R., and Samarth, S. S., (1963) in Proceedings First Intern.

Pharmacological Meeting ,Vol.VII, pp. 377.

Ammen, V.K. (1975) Zur bronchoskopischen Untersuchung bei Tuberkulosen vor und

nach Behandlung mit NA 872. Wiener Medizinische Wochenschrift 125, Suppl. 23, 44-

46.

Andersson P., (1981) Antigen induced bronchial anaphylaxis in actively sensitized guinea

pigs: effect of long-term treatment with sodium cromoglycate and aminophylline. Br. J.

Pharmacol 74:601-609.

Antonicelli F., M. Parmentier, E. M. Drost, N. Hirani, I. Rahman, K. Donaldson, and W.

Macnee. Nacystelyn inhibits oxidant-mediated interleukin-8 expression and NF-kappa B

nuclear binding in alveolar epithelial cells. Free Radic. Biol. Med. 32:492–502, 2002.

137

Aoki S., Boubekeur K., Kristersson A., Morley J., and Sanjar S., (1988) Is allergic

airway hyperreactivity of the guinea pig dependent on eosinophil accumulation in the

lung? Br. J. Pharmacol, 94, 365-371.

Aruoma, O. I.; Halliwell, B.; Laughton, M. J.; Quinlan, G. J.; Gutteridge, J. M. C.

(1989) The mechanism of initiation of lipid peroxidation: evidence against a

requirement for an iron (II)-iron (III) complex. Biochem. J. 258:617–620.

Ashurst, S., Malton, A., Prime, D., Sumby, B., (2000) Latest advances in the

development of dry powder inhalers. Pharm. Sci. Technol. 3(7), 246–256.

Atal CK; 1980; Chemistry and Pharmacology of Vasicine—A New Oxytocic and

Abortifacient, Raj Bandhu Industrial Co, New Delhi, 148.

Baba K, Satake T, Takagi K and Tomita T., (1986) Effects of verapamil on the

response of the guinea-pig tracheal muscle to carbachol. Br J Pharmacol 88:441– 449.

Babu KS, Arshad SH, Holgate ST., (2001) Omalizumab, a novel anti-IgE therapy in

allergic disorders. Expert Opin Biol Ther; 1: 1049–58.

Bai TR, Knight DA. (2005) Structural changes in the airways in asthma: observations

and consequences. Clin Sci (Lond). 108:463-477.

Barnes PJ., (1990) Effect of corticosteroids on airway hyperresponsiveness. Am Rev

Respir Dis; 141:S70–6.

Barnes PJ., (1990) Reactive oxygen species and airway inflammation. Free Rad Biol

Med; 9: 235–243.

Barnes PJ., (1995) Inhaled glucocorticoids for asthma. N Engl J Med; 332:868–75.

Barry, P.W., O’Callaghan, C., (2003) The influence of inhaler selection on efficacy of

asthma therapies. Adv. Drug Deliv. Rev. 55(7), 879– 923.

Beeh K. M., Beier J., Esperester A., Paul L. D. (2008) Antiinflammatory properties of

Ambroxol, Eur J Med Res; 13: 557-562.

138

Bel EH, Timmers MC, Zwinderman AH, Dijkman JH, Sterk PJ., (1991) The effect of

inhaled corticosteroids on the maximal degree of airway narrowing to methacholine in

asthmatic subjects. Am Rev Respir Dis; 143:109–13.

Bethesda MD; (1991) National Asthma Education and Prevention Program, Expert

Panel Report: Guidelines for the Diagnosis and Management of Asthma, National

Institutes of Health Pub. No. 91-3642.

Bethesda, MD; (1997) National Asthma Education and Prevention Program, Expert

Panel Report 2: Guidelines for the Diagnosis and Management of Asthma, National

Institutes of Health Pub. No. 97-4051.

Bhaskar KR, O'Sullivan DD, Coles SJ, Kozakewich H, Vawter GP, Reid LM.(1988)

Characterization of airway mucus from a fatal case of status asthmaticus. Pediatr

Pulmonol; 5:176-182.

Bhide, M. B., Naik P. V. and Haramsheth D. R., (1976) Recent Advances in

Pharmacology of Antiasthmatic drugs of Indian origin, U.G.C. Seminar.

Bhide, M. B., Naik, P. V and Ghooi, R. B, (1974). Xth Scientific Seminar In Indian

Medicine, Institute of Medical Sciences, Banaras Hindu University, Banaras,

Bhowmik Angshu, Chahal Kamaljeet, Austin Gillian, Chakravorty Indranil, (2009)

Improving mucociliary clearance in chronic obstructive pulmonary disease.,

Respiratory Medicine, 103, 496-502.

Biagioli MC, Kaul P, Singh I, Turner RB., (1999) The role of oxidative stress in

rhinovirus induced elaboration of IL-8 by respiratory epithelial cells. Free Rad Biol

Med; 26: 454–462.

Bianchi M, Mantovani A, Erroi A, Dinarello CA, Ghezzi P. (1990) Ambroxol inhibits

interleukin 1 and tumor necrosis factor production in human mononuclear cells.

Agents Actions. 31:275-279.

Borish L., (2002) The role of leukotrienes in upper and lower airway inflammation

and the implications for treatment. Ann Allergy Asthma Immunol, 88:16–22.

139

Bousquet J, Chanez P, Lacoste JY, Barneon G, Ghavanian N, Enander I, (1990).

Eosinophilic inflammation in asthma. N Engl J Med 323:1033-39

British Thoracic Society, (1997) National Asthma Campaign, Royal College of

Physicians of London., The British Guidelines on Asthma Management, 1995 Review

and Position Statement, Thorax 52 (Suppl. 1), S1–S21.

Cambridge, G. W., Jansen, A. B. A., and Jarman, D. A., (1962) Bronchodilating

action of vasicine and related com- pounds.Nature, 196, pp. 1217.

Campbell I. A., (1979) Current Medical Research and Opinion Vol. 6, Suppl. 6, The

additive and/or synergistic effects of combined Sympathomimetic and methylxanthine

therapy.

Canning Brendan J., Chou Yangling. (2008) Using guinea pigs in studies relevant to

asthma and COPD; Pulmonary Pharmacology & Therapeutics 21; 702–720.

Cantin AM, North SL, Hubbard RC, Crystal RG. (1987) Normal alveolar epithelial

lining fluid contains high levels of glutathione. J Appl Physiol; 63(1):152–157.

Casoni, G. L., P. Chitano, S. Pinamonti, M. Chicca, A. Ciaccia, L. Fabbri, and A.

Papi. (2003) Reducing agents inhibit the contractile response of isolated guinea-pig

main bronchi. Clin. Exp. Allergy. 33:999–1004.

Chang RK, Guo X, Burnside B, Couch R., (2000) Fast-dissolving tablets. Pharm

Technol; 24:52-8.

Chibana K, Trudeau JB, Mustovich AT, Hu H, Zhao J, Balzar S, Chu HW, Wenzel

SE. (2008) IL-13 induced increases in nitrite levels are primarily driven by increases

in inducible nitric oxide synthase as compared with effects on arginases in human

primary bronchial epithelial cells. Clin Exp Allergy; 38:936–946.

Chopra, R. N., (1925) Ind.J.Med.Res. pp. 1320. (C.F.: Malhotra S, Koul S K., Sharma

R.L. Anand K.K, Gupta O.P and Dhar K.L. Studies on some biologically active

azepinoquinazolines: part I, Indian Journal of Chemistry, Vol. 27B, October 1988,

pp.937-940.)

140

Chung H. S., Hon P. M.., Lin G., But P. P. H., Dong, H., (2003) Antitussive activity

of Stemona alkaloids from Stemona tuberosa. Planta medica 69, pp. 914.

Cluroe A, Holloway L, Thomson K, Purdie G, Beasley R. (1989) Bronchial gland

duct ectasia in fatal bronchial asthma: association with interstitial emphysema. J Clin

Pathol; 42:1026-1031.

Connett G. J., Warde C., Wooler E., Lenney W. (1994) Prednisolone and salbutamol

in the hospital treatment of acute asthma. Arch Dis Childhood; 70: 170-173

D.P. Jindal, R. Chattopadhaya, M. Minu, (1998) Indian Drugs 35; 606–639.

Davidson, I.G., Langner, E.J., Plowman, S.V., Blair, J.A., (2003) Release mechanism

of insulin encapsulated in trehalose ester derivative microparticles delivered via

inhalation. Int. J. Pharm. 254, 211-222.

DcMonchy JGR, Kauffman IF, Venge P, Koeter GH, Jansen HM, Sluiter 11J, (1985)

Bronchoalvoolar eosinophilia during allergen-induced late asthmatic reactions. Am

Rev Respir Dis; 131:373-76

De Mey C, Peil H., Koelsch, S., Bubeck J., Vix J.M., EBM-based clinical

documentation of the efficacy and safety of lozenges containing ambroxol in treating

acute uncomplicated sore throat, manuscript in preparation).

Del Maestro RF, Bjork J, Arfors K. (1981) Increase in microvascular permeability

induced by enzymatically generated free radicals. I. In vivo study. Microvasc Res; 22:

239–254.

Dempsey OJ, Kennedy G, Lipworth BJ. (2002) Comparative efficacy and anti-

inflammatory profile of once-daily therapy with leukotriene antagonist or low-dose

inhaled corticosteroid in patients with mild persistent asthma. J Allergy Clin

Immunol; 109:68–74.

Denburg JA, Sehmi R, Saito H, Pil-Seob J, Inman MD, O’Byrne PM. (2000) Systemic

aspects of allergic disease: Bone marrow responses. J Allergy Clin Immunol;

106:S242–S246.

141

Deol, P., Khuller, G.K., (1997) Lung specific stealth liposomes: Stability,

biodistribution and toxicity of liposomal antitubercular drugs in mice. Biochim.

Biophys. Acta. 1334, 161-72.

Diaz J, Vara E, Torres-Melero J. (1994) Nitrite/nitrate and cytokine levels in

bronchoalveolar lavage fluid of lung cancer patients. Cancer; 74: 1546-51.

Dijkstra, J., Van Galen, M., Scherphof, G.L., (1984) Effects of ammonium chloride

and chloroquine on endocytic uptake of liposomes by Kupffer cells in vitro. Biochim.

Biophys. Acta 804, 58–97.

Disse BG. (1987) The pharmacology of ambroxol. Eur J Respir Dis; 153:255–62.

Doelman CJA, Bast A. (1990) Oxygen radicals in lung pathology. Free Rad Biol

Med; 9: 381–400.

Doelman CJA, Leurs R, Oosterom WC, Bast A. (1990) Mineral dust exposure and

free radical-mediated lung damage. Exp Lung Res; 16: 41–55.

Dolovich, M.B., Ahrens, R.C., Hess, D.R., Anderson, P., Dhand, R., Rau, J.L., (2005)

Device selection and outcomes of aerosol therapy: evidence based guidelines:

American College of Chest Physicians/American College of Asthma, Allergy, and

Immunology. Chest. 127(1), 335–371.

Drummond, D., Zignani, M., Leroux, J.C., (2000) Current status of pH-sensitive

liposomes in drug delivery. Prog. Lipid Res. 39, 409–460.

Dutoit JI, Salome CM, Woolcock AJ. (1987) Inhaled corticosteroids reduce the

severity of bronchial hyperresponsiveness in asthma but oral theophylline does not.

Am Rev Respir Dis; 136:1174–8.

Edwards, D.A., Caponetti, G., Harksh, J.S., Lotan, N., Hanes, J., Ben-Jabria, A.A.,

(2005) Aerodynamically light particles for pulmonary drug delivery.

US20050244341.

Ellis AG. (1908) The pathological anatomy of bronchial asthma. Am J Med

Sci;136:407–29.

142

Ellmann ,G. L. (1959) Tissue sulfhydryl groups. Arch Biochem Biophys. 82, 70-77.

Ernst P., FitzGerald J.M., Spier S., (1996) Can. Respir. J. 3, 89–100.

Evans DJ, Barnes PJ, Spaethe SM, van Alstyne EL, Mitchell MI, O’Connor BJ.

(1996) Effect of a leukotriene B4 receptor antagonist, LY293111, on allergen induced

responses in asthma. Thorax; 51:1178–84.

Evans DJ, Taylor DA, Zetterstrom O, Chung KF, O’Connor BJ, Barnes PJ, (1997)

comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled

budesonide for moderate asthma. N Engl J Med; 337:1412–8.

Farr, S.J., Kellaway I.W., Carman- Meaking, B., (1987) Assessing the potential of

aerosol generated liposomes from pressurised pack formulations. J. Contr. Rel. 5,

119-127.

Farr S.J., Kellaway I.W., Parry Jones D.R., Woolfrey S.G., (1985) 99m-Technetium

as a marker of liposomal deposition and clearance in the human lung. Int. J. Pharm.

26, 303- 316.

Felix K., Pairet M., Zimmermann R., (1996) The antioxidative activity of the

mucoregulatory agents: ambroxol, bromhexine and N-acetyl-L-cysteine. A pulse

rediolysis study, Life Sci. 59, 1141-1147.

Fiel SB, Vincken W. J., (2006) Systemic corticosteroid therapy for

acute asthma exacerbations. Asthma; 43(5):321-31.

Fischer J, Pschorn U, Vix JM, Peil H, Aicher B, Mueller A, de Mey C. (2002)

Efficacy and tolerability of ambroxol hydrochloride lozenges in sore throat.

Randomised, doubleblind, placebo-controlled trials regarding local anaesthetic

properties. Arzneimittelforschung., 52:256-263.

Foresi A, Bertorelli C, Pesci A, Chetta A, Olivieri D. (1990) Inflam matory markers in

bronchoalveolar lavage and in bronchial biopsy in asthma during remission. Chest

98:528-35

143

Gazzola, R., Viani, P., Allevi, P., Cighetti, G., Cestaro, B., (1997) pH sensitivity and

plasma stability of liposomes containing N-stearoylcysteamine. Biochim. Biophys.

Acta. 1329, 291–301.

Ghose, T. P., Krishna S., Narang, K. S. and Ray ,J. N., (1932) A Bronchodilator

Alkaloid (Vasicinone) from Adhatoda vasica Nees. J.Chem. Soc., pp. 2740.

Gillissen A, Bartling A, Schoen S, Schultze-Werninghaus G. (1997) Antioxidant

function of ambroxol in mononuclear and polymorphonuclear cells in vitro. Lung.

175:235-242.

Gillissen A., SchaÈrling B., Jaworska M., Bartling A., Rasche K., Schultze-

Werninghaus G., (1997) Oxidant scavenger functionof ambroxol in vitro: a

comparison with N-acetylcysteine, Res. Exp. Med. 196, 389-398.

Grange John M. and Snell Noel J.C. (1996); Activity of bromhexine and ambroxol,

semi-synthetic derivatives of vasicine from the Indian shrub Adhatoda vasica against

mycobacterium tuberculosis in vitro. Journal of Ethnopharmacology 50, 49-53.

Gupta O.P., Sharma M.L., Ghatak B.J., Atal C.K., (1977) Indian J. Med. Res. 66 (4)

680–691.

Gupta S.S., Parse R.M., Ram A.K. (1968) Development of anti-allergic and anti-

histaminic activity in relation to histamine releasing effects of a plant saponin from

Clerodendron serratum. Asp. Allergy Appl. Immunol. 2: 133-142.

Halliwell B, Gutteridge JMC. (1999) Free Radicals in Biology and Medicine. 3rd ed.

Oxford Science Publications, Oxford, England: Oxford University Press, 936, xxxi,

[19] of col. plates.

Hamelmann E, Gelfand EW. (2001) IL-5-induced airway eosinophilia-the key to

asthma? Immunol Rev; 179:182-91.

Hanazawa T, Kharitonov SA, Barnes PJ. (2000) Increased nitrotyrosine in exhaled

breath condensate of patients with asthma. Am J Respir Crit Care Med; 162: 1273–

1276.

144

Hansjorg, E., Hottkowittz, T., (2008) Phospholipids with unsaturated alkyl and acyl

chains. US20080214849.

Hashiba Eiji, Sato Tetsumi, Hirota Kazuyoshi, Hashimoto Yoshio, and Matsuki

Akitomo; (1999) The Relaxant Effect of TAZQ on Guinea Pig Tracheal Muscle Is

Independent of Airway Epithelial Function and b-Adrenoceptor Activity; Anesth

Analg;89:191–6

Hermecz I., Vasvari-Debreczy L., Horvath A., Balogh M., Kakosi J., Dev V C.,

Rodriguez L. (1987) J. Med. Chem. 30. 1543–1549.

Hersch, E.M., Petersen, E.A., Proffitt, R.T., Bracken, K.R., Chiang, S.M., (1999)

Antibiotic formulation and use for bacterial infections. US5958449.

Holgate ST, Bradding P, Sampson AP. (1996) Leukotriene antagonists and synthesis

inhibitors: new directions in asthma therapy. J Allergy Clin Immunol; 98:1–13.

Hooper, I. D., (1888), Novel nor-harmal alkaloid from Adhatoda vasica. Pharm.J., 18,

pp. 841.

Huakg, A., Kennel, S.J., Huang, L., (1983) Interaction of immunoliposomes with

target cells. J. Biol. Chem. 258, 14034–14040.

Hermecz I., Vasvari-Debreczy L., Horvath A., Balogh M., Kakosi J., Dev V.C.,

Rodriguez L., (1987) Nitrogen bridgehead compounds. 66. Bronchodilator nitrogen

bridgehead compounds with a pyrimidinone moiety. J. Med. Chem. 30; 1543–1549.

Ishiura Y, Fujimura M, Yamamori C, Nobata K, Myou S, Kurashima K, Michishita

Y, Takegoshi T. (2003) Effect of carbocysteine on cough reflex to capsaicin in

asthmatic patients. Br J Clin Pharmacol; 55:504-510.

Jain, K.K., (2008) Drug delivery systems – An overview. Methods. Mol. Biol. 437, 1-

50.

Jarjour NN, Calhoun WJ. (1994) Enhanced production of oxygen radicals in asthma. J

Lab Clin Med; 123: 131–136.

Jeffery PK. (1992) Pathology of asthma. Br Med Bull; 48:23-39.

145

Jin X, Zhang H. The Experiment and Clinical Study of Ambroxol Against the Airway

Inflammation of Chronic Hypoxic Rat and Patients with COPD. Eur Respir J. 2002;

20:257.

Jin, T., Zarif, L., Mannino, R., (2000). Nanocochleate formulations, process of

preparation and method of delivery of pharmaceutical agents. US20006153217.

Jindal D.P., Chattopadhaya R., Minu M., (1998) Development of beta 2-adrenoceptor

agonists: (antiasthmatics-1). Indian Drugs; 35, 606–639.

Jing Zhou, Sohshi Iwasaki, Michiaki Yamakage. (2010) Synergic Bronchodilator

Effects of PDE3 Inhibitors with Sevoflurane in Asthmatic Guinea Pigs, Proceedings

of the 2010 Annual Meeting of the American Society Anesthesiologists.

John M. Grange, Noel J.C., Snell. (1996) Activity of bromhexine and ambroxol, semi-

synthetic derivatives of vasicine from the Indian shrub Adhatoda vasica, against

Mycobacterium tuberculosis in vitro. Journal of Ethnopharmacology 50. 49-53.

Johnson M, Rennard S. (2001) Alternative mechanisms for long-acting beta(2)-

adrenergic agonists in COPD. Chest;120:258–70.

Johri RK, Zutshi U. (2000) Mechanism of action of 6, 7, 8, 9, 10, 12-hexahydro-

azepino-[2, 1-b] quinazolin-12-one-(RLX)-a novel bronchodilator Indian J Physiol

Pharmacol. Jan; 44(1): 75-81.

Jones PW, Willits LR, Burge PS, Calverley PMA. (2003) Disease severity and the

effect of fluticasone propionate on chronic obstructive pulmonary disease

exacerbations. Eur Respir J; 21:68-73.

Joshi, M., Misra, A., (2001a) Dry powder inhalation of liposomal Ketotifen fumarate:

formulation and characterization. Int. J. Pharm. 223, 15- 27.

Joshi, M.R., Misra, A., (2001b) Liposomal budesonide for dry powder inhaler:

preparation and stabilization. AAPS Pharm. Science. Tech. 2, E25.

Juniper EF, Kline PA, Vanzieleghem MA, Hargreave FE. (1991) Reduction of

budesonide after a year of increased use: a randomized controlled trial to evaluate

146

whether improvements in airway responsiveness and clinical asthma are maintained. J

Allergy Clin Immunol;87: 483–9.

Justo O.R., Moraes A.M. (2003) Incorporation of antibiotics in liposomes designed

for tuberculosis therapy by inhalation. Drug Deliv. 10, 201–207.

Beeh K. M., Beier J., Esperester A., Paul L. D. (2008) Anti-inflammatory properties

of ambroxol; Eur J Med Res 13: 557-562;

Katsumata U, Miura M, Ichinose M, (1990) Oxygen radicals produce airway

constriction and hyperresponsiveness in anesthetized cats. Am Rev Respir Dis; 141:

1158–1161.

Kerr J.F.R., Wyllie A.H., Currie A.R., (1972) Apoptosis: a basic biological

phenomenon with wide-ranging implications in tissue kinetics, Br. J. Cancer 26;

239±257.

Kharitonov SA, Yates D, Robbins RA, Logan- Sinclair R, Shinebourne EA, Barnes

PJ. (1994) Increased nitric oxide in exhaled air of asthmatic patients. Lancet; 343:

133–135.

Kim S.H., Johnson V.J., Sharma R.P., (2002) Mercury inhibits nitric oxide production

but activates proinflammatory cytokine expression in murine macrophage: differential

modulation of NF-jB and p38 MAPK signalling pathways, Nitric Oxide 7, 67–74.

Kim, J.C., Kim, J.D., (2001) Preparation by spray drying of amphotericin B -

phospholipid composite particles and their anti-cellular activity. Drug Deliv. 8, 143-

147.

Kirby JG, Hargreave FE, Gleich GJ and O’Byrne PM (1987) Bronchoalveolar cell

profiles of asthmatic and nonasthmatic subjects. Am Rev Respir Dis 136:379–383.

Kobayashi K, Nishimura Y, Yamashita T, Nishiuma T, Satouchi M, Yokoyama M.

(2006) The effect of overexpression of endothelial nitric oxide synthase on

eosinophilic lung inflammation in a murine model. Int Immunopharmacol; 6:1040–

1052.

147

Konduri, K.S., Nandedkar, S., Duzgunes, N., Suzara, V., Artwohl, J., Bunte, R.,

Gangadharam, P.R., (2003) Efficacy of liposomal budesonide in experimental asthma.

J. Allergy Clin. Immunol. 111(2), 321-327.

Krishnan JA, Riekert KA, McCoy JV, (2004) Corticosteroid use after hospital

discharge among high-risk adults with asthma. Am J Respir Crit Care

Med;15(170):1281–5.

Kshirsagar, N.A., Pandya, S.K., Kirodian, B.G., Sanath, S., (2005) Liposomal drug

delivery system from laboratory to clinic. J. Postgraduate Med. 51(5), 5- 15.

Kulkarni PA, Ganu GP, Bhujbal SS, Jadhav SW, Dongre PR, Agrawal VS, Talele SG,

Kasture PV. (October–December 2010) Research Journal of Pharmaceutical,

Biological and Chemical Sciences Preclinical evaluation of co administered

bronchodilators and corticosteroid for the treatment of asthma.

Nepali Kunal, Bande Mukunda S., Sapra Sameer, Garg Atul, Kumar Sunil, Sharma

Punita, Goyal Rohit, Satti Naresh Kumar, Suri Om Parkash, Dhar Kanaya Lal (2011),

Antitussive effects of Azepino[2,1-b]quinazolones. Medicinal Chemistry Research,

DOI: 10.1007/s00044-011-9641-1 (article under press).

Labana, S., Pandey, R., Sharma, S., Khuller, G.K., (2002) Chemotherapeutic activity

against murine tuberculosis of once weekly administered drugs (isoniazid and

rifampicin) encapsulated in liposomes. Int. J. Antimicrob. Agents. 20(4), 301-304.

Laforest L, Pacheco Y, Bousquet J. (2005) How appropriate is asthma therapy in

general practice? Fundam Clin Pharmacol; 19:107–15.

Laforest L, Van Ganse E, Devouassoux G. (2006) Management of asthma in patients

supervised by primary care physicians or by specialists. Eur Respir J; 27:42–50.

Laforesta Laurent, Van Eric, Devouassouxb Gilles, El Hasnaouic A., Osmand Liesl

M., Bauguile Gisele, Chambae Genevieve, (2008) Dispensing of antibiotics,

antitussives and mucolytics to asthma patients: A pharmacy-based observational

survey. Respiratory Medicine, 102, 57–63

148

Lahiri, P. K., and Pradhan, S. N., (1964)Pharmacological evaluation of vssicinol- an

alkaloid from adhatoda vasica. Indian J.Exp.Biol.,2, pp. 219.

Lam S, Leriche JC, Kijek K, Phillips D. (1985) Effect of bronchial lavage volume on

cellular and protein recovery. Chest; 88:856-59

Lapenna D., de Gioia S., Ciofani G., Cuccurullo F., (1994) Ambroxol is a scavenger

of hypochlorous acid and monochloramine, Pharmacology 49, 132-135.

Laude, E. A., Morice, A. H., Grattan, T. J., (1994) Pulm. Pharmacol, 7, pp. 179–184

Laurence, D. R., (1973) Clinical Pharmacology, The English Language Book Society,

Linostone. 15.

Ledwozyw A., Jablonka S., Tusinska E., (1991) The effect of ambroxol on

peroxidative processes in dog lung mitochondria, Pol. Arch. Weter. 31, 105-113.

Lee CS, Jang YY, Han ES. (1999) Depressant effects of ambroxol on lipopoly-

saccharide- or fMLP-stimulated free radical production and granule enzyme release

by alveolar macrophages. Pulm Pharmacol Ther; 72:275– 84.

Leung DY, Sampson HA, Yunginger JW, Burks AW, Jr., Schneider LC, Wortel CH,

Davis FM, Hyun JD, Shanahan WR, Jr. (2003) Effect of anti-IgE therapy in patients

with peanut allergy. N Engl J Med; 348:986–93.

Leung KB, Flint KC, Brostoff J, Hudspith BN, Johnson NM, Lau HY, Liu WL,

Pearce FL. (1988) Effects of sodium cromoglycate and nedocromil sodium on

histamine secretion from human lung mast cells. Thorax; 43:756–61.

Levine SJ. (1995) Bronchial epithelial cell-cytokine interactions in airway

inflammation. J Invest Med; 43: 241–249.

Maarsingh H, Leusink J, Zaagsma J, Meurs H. (2006) Role of the L-

citrulline/Larginine cycle in iNANC nerve-mediated nitric oxide production and

airway smooth muscle relaxation in allergic asthma. Eur J Pharmacol; 546:171–176.

Mahindroo Neeraj, Ahmad Zabeer, Bhagat Asha, Lal Bedi Kasturi, Khajuria Ravi

Kant, Kapoor Vijay Kumar, Dhar Kanaya Lal. (2005) Synthesis and structural

149

activity relationships of vasicine analogues as bronchodilatory agents. Med Chem Res

14:6; 347-368.

Malerba M, Ponticiello A, Radaeli A, Bensi G, Grassi V. (2004) Effect of twelve-

months therapy with oral ambroxol in preventing exacerbations in patients with

COPD. Doubleblind, randomized, multicenter, placebo-controlled study (the

AMETHIST Trial). Pulm Pharmacol Ther; 17:27-34.

Malhotra, S, Koul, S. K., Singh, S., Singh, G. B., Dhar, K.L., (1989), Studies on some

biologically active azepinoquinazolines: part II; Indian J. Chem., 28B, pp. 100.

Malhotra S, Koul S K,. Sharma R.L,.Anand K.K,. Gupta O.P and Dhar K.L. (1988)

Studies on some biologically active azepinoquinazolines: part I, Indian Journal of

Chemistry, Vol. 27B, pp.937-940

Mansour, H. M., Ree, Y.K., Wu, X., (2009) Nanomedicine in pulmonary delivery. Int.

J. Nanomed., 299-319.

Martin, P.G., Zeng, X.M., Marriott, C., (1995) The controlled delivery of drugs to the

lungs. Int. J. Pharm. 124, 149- 164.

Melillo G, Cocco G. (1986) Ambroxol decreases bronchial hyperreactivity. Eur J

Respir Dis.; 69:316-320.

Mezel, M., Hung, O., (2004) Pain management with liposome-encapsulated analgesic

drugs: USRE200438407.

Misra, A., Chougule, M.B., Padhi, B.K., Jinturkar, K.A., (2007) Development of Dry

Powder Inhalers. Recent Pat. Drug Deliv. Formul. 1(1), 11-21.

Misra, A., Shah, S.P., (2004) Liposomal Amikacin Dry Powder Inhaler: Effect of

Fines on in-vitro Performance. AAPS Pharm. Sci. Tech. 5 (4), 65, 1-7.

Mitchell, J.P., Nagel, M.W., (2004) Particle size analysis of aerosols from medicinal

inhalers. KONA Powder and Particle No22, 32- 64.

MMWR. (1996) Asthma mortality and hospitalizations among children and young

adults: United States. MMWR 45:350.

150

Momekova, D., Rangelov, S., Yanev, S., Nikolova, E., Konstantinove, S., Rombergf,

B., (2007) Long-circulating, pH-sensitive liposomes sterically stabilized by

copolymers bearing short blocks of lipid-mimetic units. E. J. Pharm. Sci. 3(2), 308–

317.

Mooris, R. C., Hanford, W. E., and Adams R, (1935), Ind.J.Chem.Soc., 57, pp. 951.

Morgenroth, K. and Schlake, W. (1975) Unspezifische Begleitreaktion in der

Bronchialwand bei der Lungentubcrkulos¢ und ihre Behandlung mit NA 872. Licht-

und electronenmikroskopische Untersuchungen an der Bronchialwand bei Patienten

mit Lungentuberkulose. Wiener Medizinische Wochenschrift 125, Suppl. 23, 34-43.

Morton, D., Ganderton, D., Staniforth, J., Tobyn, M., Eason, S., Harmer, Q., (2007)

Dry powder composition comprising a Benzodiazepine for pulmonary inhalation. US

2007/0081948A1.

Muller, R.H., Mader, K., Gohla, S., (2000) Solid lipid nanoparticles (SLN) for

controlled drug delivery – a review of the state of the art. Eur. J. Pharm. Biopharm.

50, 161–177.

Narahara Iroyuki, Tatsuta Masaharu, Iishi Hiroyasu, Baba Miyako, Mikuni Tomiko,

Uedo Noriya, Sakai Noriko, Yano Hiroyuki; (2001) Attenuation by ambroxol of

monochloramine-enhanced gastric carcinogenesis: a possible prevention against

Helicobacter pyloriassociated gastric carcinogenesis H Cancer Letters 168; 117±124.

Nimmagadda SR, Spahn JD, Nelson HS, Jenkins J, Szefler SJ, Leung DY. (1998)

Fluticasone propionate results in improved glucocorticoid receptor binding affinity

and reduced oral glucocorticoid requirements in severe asthma. Ann Allergy Asthma

Immunol; 81:35–40.

Nobata K, Fujimura M, Ishiura Y, Myou S, Nakao S. (2006) Ambroxol for the

prevention of acute upper respiratory disease. Clin Exp Med; 6:79-83.

Norris AA. (1996) Pharmacology of sodium cromoglycate. Clin Exp Allergy;

26(Suppl 4):5–7.

151

Nowak D, Antczak A, Pietras T, Bialasiewicz P, Krol M (1994). Protective effect of

ambroxol against heat- and hydrogen peroxide-induced damage to lung lipids in mice.

Eur Respir J 7:1629–1634.

Nowak D, Pietras T, Antczak A, Krol M, Piasecka G (1993). Ambroxol inhibits

endotoxin-induced lipid peroxidation in mice. Pol J Pharmacol 45:317–322.

Nowak D., Antczak A., Krol M., Bialasiewicz P., Pietras T., (1994) Antioxidant

properties of ambroxol, Free Radic. Biol. Med. 16, 517-522.

Gupta O.P., Sharma M.L., Ghatak B.J., Atal C.K., (1977) Indian J. Med. Res. 66 (4)

680–691.

Ohkawa H, Ohishi N, Yagi K. (1979) Assay for lipid peroxides in animal tissues by

thiobarbituric acid reaction. Anal Biochem; 95: 351-8.

Oliveira I.S., Brunialti M.K.C., Koh I.H.J., Junqueira V.B.C.R., Salomao. (2006)

Effect of pentoxifylline on lunginflammation and gas exchangein a sepsis-induced

acute lung injury model, brazilian journal of medical and biological research, 39:

1455-1463.

Pandey, S., Shukla, P., Bhatt, S., Choudhary, V., Viral D, Subhash, V., (2009)

Microfine Dry Powder: Pulmonary Drug Delivery System. J. Pharm. Res. 2(7), 1159-

1162.

Paoliello-Paschoalato AB, Oliveira SH, Cunha FQ. (2005) Interleukin 4 induces the

expression of inducible nitric oxide synthase in eosinophils. Cytokine; 30:116–124.

Parameswaran K, Inman MD, Watson RM, Morris MM, Efthimiadis A, Ventresca

PG, Lam R, O’Byne PM, Hargreave FE. (2000) Protective effects of fluticasone on

allergen-induced airway responses and sputum inflammatory markers. Can Respir J;

7:313–9.

Park, J.H., Lee, S., Kim, J.H., Park, K., Kim, K., Kwon, I.C., (2008) Polymeric

nanomedicine for cancer therapy. Prog. Polym. Sci. 33, 113–137.

152

Peter JB, Robert AM, and George RB, (1995) Principles of pharmacology: Basic

concepts and clinical applications. New York; Thomson Publishing Company: p.

589.

Pfeifer S, Zissel G, Kienast K, Mueller-Quernheim J. (1997) Reduction of cytokine

release of blood and bronchoalveolar mononuclear cells by ambroxol. Eur J Med Res;

2:129-132.

Phipps RJ, Denas SM, Sielczak MV, Wanner A. (1986) The effect of 0.5ppm ozone

on glycoprotein secretion, ion and water fluxes in sheep trachea. J Appl Physiol; 60:

918–927.

Poole, PJ, Black PN. (2001) Oral mucolytic drugs for exacerbations of chronic

obstructive pulmonary disease: systematic review. Br Med J.; 322:1-6.

Prelog, V. and Wielard, P., Helv, (1944), Chim. Acta, 27, pp. 1127.

Rabe KF, Adachi M, Lai CK, (2004) Worldwide severity and control of asthma in

children and adults: the global asthma insights and reality surveys. J Allergy Clin

Immunol; 114:40–7.

Radhakrishnan, R., (1991) Novel liposome composition for the treatment of

interstitial lung diseases. US5049389.

Radi R, Beckman J, Bush K, Freeman B. (1991) Peroxynitriteinduced membrane lipid

peroxidation: The cytotoxic potential of superoxide and nitric oxide. Arch Biochem

Biophys; 288: 481–487.

Rahman, and I, W. Macnee. (2000) Oxidative stress and regulation of glutathione in

lung inflammation. Eur. Respir. J. 16:534–554.

Read J, Rebuck AS. (1969) Steroid-sparing effect of disodium cromoglycate (‘Intal’)

in chronic asthma. Med J Aust; 1:566–9.

Reinsprecht M, Pecht I, Schindler H, Romanin C. (1992) Potent block of Cl channels

by antiallergic drugs. Biochem Biophys Res Commun; 188:957–63.

Reynolds, T. M., Robinson R., (1934), Nature, 134, pp. 142.

153

Rhoden KJ, Barnes PJ. (1989) Effect of hydrogen peroxide on guinea-pig tracheal

muscle in vitro: role of cyclooxygenase and airway epithelium. Br J Pharmacol; 98:

325–330.

Riaz, M., (1996) Liposomes preparation methods. Pak. J. Pharm. Sci. 19(1), 65-77.

Ricciardolo FL. Multiple roles of nitric oxide in the airways. Thorax 2003; 58:175–

182.

Rohde G, Schlosser B, Arinir U, Kronsbein J, Knoop H, Ringshausen F, Schultze-

Werninghaus G. (2007) The role of respiratory infections in chronic obstructive

pulmonary disease. Med Klin.; 102:893-898.

Saleh D, Barnes PJ, Giaid A. (1997) Increased production of potent oxidant

peroxynitrite in the lungs of patients with idiopathic pulmonary fibrosis. Am J Respir

Crit Care Med; 155: 1763-69.

Sally-Ann Cryan, (2005) Carrier-based Strategies for Targeting Protein and Peptide

Drugs to the Lungs. The AAPS Journal. 7 (1), E20- E40.

Salmeron S, Guerin JC, Godard P, Renon D, Henry-Amar M, Duroux P, Taytard A.

(1989) High doses of inhaled corticosteroids in unstable chronic asthma. A

multicenter, double-blind, placebocontrolled study. Am Rev Respir Dis; 140:167–71.

Schutz A, Gund HJ, Pschorn U, Aicher B, Peil H, Mueller A, de Mey C, Gillissen A.

(2002) Local aneasthetic properties of ambroxol hydrochloride lozenges in view of

sore throat. Clinical proof of concept. Arzneimittelforschung.; 52:194-199.

Sears, M. R. (1991) Worldwide trends in asthma mortality. Bull. Int. Union Tuberc.

66:79.

Sen, J. N. and Ghose, T. P., (1924) Alkaloid from leaves of. Adhatoda vasica; J.

Indian Chem. Soc., 1, pp. 315.

Sethi S. (1999) Infectious exacerbations of chronic bronchitis: diagnosis and

management. JAC.; 43:S97-S105.

154

Sharma M.L., Khajuria A., Kaul A., Chand D., (1992) Immunopharmacological

properties of azepine (2,1-b) quinazolin-12(6H)-one-7,8,9,10-tetrahydro. Int J

Immunopharmacol. Aug; 14 (6): 979-86.

Sharma S C, Zutshi U, Gupta O P, Dhar K L and Atal C K; (April1996) Isolation,

characterization and partial synthesis of a major metabolite of a potent bronchodilator

7, 8, 9, 10-tetrahydroazepino [2, 1-b]-quinazoline-12 (6H)-one; Indian journal of

Chemistry, vol.35B, pp.345-348.

Sharma R.L, Gupta R.K, Choudhary B.K, Dhar K.L and Atal C. K, Indian J Chem,

18B (1979) 449. (C.F.: Malhotra S, Koul S K,. Sharma R.L,.Anand K.K,. Gupta O.P

and Dhar K.L. Studies on some biologically active azepinoquinazolines: part I, Indian

Journal of Chemistry, Vol. 27B, October 1988, pp.937-940.)

Sheffer AL. Global initiative for asthma. NHLBI/WHO Workshop report; (1995) The

2002 revised edition is available online at http:// www.ginasthma.com. National

Institutes of Health, National Heart, Lung and Blood Institute Publication No 95-

3659.

Shekunov, B., (2005) Nanoparticle technology for drug delivery – From nanoparticles

to cutting-edge delivery strategies- part II. IDrugs 8(5), 402- 403.

Simoes, S., Slepushkin, V.A., Duzsgunes¸, N., Pedroso de Lima, M.C., (2001) On the

mechanism of internalization and intracellular delivery mediated by pH-sensitive

liposomes. Biochim. Biophys. Acta 1515, 23–37.

Soler M, Matz J, Townley R, Buhl R, O’Brien J, Fox H, Thirlwell J, Gupta N, Della

CG. (2001) The anti-IgE antibody omalizumab reduces exacerbations and steroid

requirement in allergic asthmatics. Eur Respir J; 18:254–61.

Spath, E., and Platzer, N., (1935), Ber.,68B CA28,2196.

Spath, E., Nikawitz, E., (1934), Ber., 67B CA 28, pp. 1705.

Straubinger, R.M., Hong, K., Friend, D.S., (1983) Endocytosis of liposomes and

intracellular fate of encapsulated molecules: encounter with a low pH compartment

after internalization of coated vesicles. Cell. 32(4), 1079–1096.

155

Svedmyr Nils and Svedmyr Xarh., (1979) Combined effects of theophylline and beta2

adrenoceptor stimulants in Asthmatics. Current Medical Research and Opinion Vol. 6,

Suppl. 6,

Tate RM, van Benthuysen KM, Shasby DM, McMurtry IF, Repine JE. (1982)

Oxygen-radical-mediated permability edema and vasoconstriction in isolated perfused

rabbit lungs. Am Rev Respir Dis; 126:802–806.

Taylor DR, Town GI, Herbison GP, Boothman-Burrell D, Flannery EM, Hancox B,

Harre E, Laubscher K, Linscott V, Ramsay CM, Richards G. (1998) Asthma control

during long-term treatment with regular inhaled salbutamol and salmeterol. Thorax;

53:744–52.

Van Den Berge M, Kerstjens HA, Meijer RJ, de Reus DM, Koeter GH, Kauffman HF,

Postma DS. (2001) Corticosteroid-induced improvement in the PC20 of adenosine

monophosphate is more closely associated with reduction in airway inflammation

than improvement in the PC20 of methacholine. Am J Respir Crit Care Med;

164:1127–32.

Van der Vliet A, O’Neill CA, Cross CE, Koostra JM, Volz WG, Halliwell B, Louie S.

(1999) Determination of low-molecular-mass antioxidant concentrations in human

respiratory tract lining fluids.Am J Physiol; 276:L289–L296.

Venugopalan, P., Jian, S., Sankar, S., Singh, P., Vyas, S.P., (2002) pH-sensitive

liposomes: mechanism of triggered release to drug and gene delivery prospects.

Pharmacie. 56, 659–671.

Verdon C.P., Burton B.A., Prior R.L., (1995) Simple pretreatment with nitrite

reductase and glucose-6-phosphate dehydrogenase quantitatively reduce nitrate while

avoiding interference by avoiding interference by NADP+ when the Griess reaction is

used to assay for nitrite, Anal. Biochem. 224. 502–508.

Vyas, S.P., Sakthivel,T., (1994) Pressurized pack- based liposomes for pulmonary

targetting of isoprenaline- development and characterization. J. Microencap. 11(4),

373- 380.

156

Wardlaw AJ, Dunnette S, Gleich GJ, Collins JV, Kay AB. (1988) Eosinophils and

mast cells in bronchoalveolar lavage in subjects with mild asthma. Am Rev Respir

Dis; 137:62–9.

Weers, J.G., Tarara, T., Clark, A., (2004) Phospholipid-based powders for inhalation.

US20040105820A1.

Weiss EB, Bellino JR. (1986) Leukotriene-associated toxic oxygen metabolites

induces airway hyperreactivity. Chest; 89: 709–716.

Wenzel SE. (1998) New approaches to anti-inflammatory therapy for asthma. Am J

Med; 104:287–300.

Williams LK, Pladevall M, Xi H, (2004) Relationship between adherence to inhaled

corticosteroids and poor outcomes among adults with asthma. J Allergy Clin

Immunol; 114:1288–93.

Wood L.G., Gibson P.G., Garg M.L.; (2003) Biomarkers of lipid peroxidation, airway

inflammation and asthma; Eur Respir J; 21: 177–186.

Wood LJ, Inman MD, Denburg JA, O’Byrne PM. (1998) Allergen challenge increases

cell traffic between bone marrow and lung. Am J Respir Cell Mol Biol; 18:759–767.

Wu W, Chen Y, Hazen SL. (1999) Eosinophil peroxidise nitrates protein tyrosyl

residues. Implications for oxidative damage by nitrating intermediates in eosinophilic

inflammatory disorders. J Biol Chem; 274: 25933–25944.

Xiao Su, Ling Wang, Yuanlin Song and Chunxue Bai1, (2003) Inhibition of

inflammatory responses by ambroxol, a mucolytic agent, in a murine model of acute

lung injury induced by lipopolysaccharide; Intensive Care Medicine; 10.1007/s00134-

003-2001.

Xu, Y. T., Hon, P. M., Jiang, R. W., Cheng, L., Li, S. H., Chan. Y. P., Xi, H. X.,

Shaw, P. C., But, P. P. H., (2006), J of Ethnopharmacol., 108, pp. 46.

Yang, Z., Huang, W., Wong, C.S., Zao, Z., (2009) Novel formulation of dehydrated

lipid vesicles for controlled release of active pharmaceutical ingredients via

inhalation. US 2009/ 0047336 A1.

157

Yates DH, Kharitonov SA, Barnes PJ. (1997) Effect of short- and longacting inhaled

beta2-agonists on exhaled nitric oxide in asthmatic patients. Eur Respir J; 10:1483–8.

Zabeer A., Bhagat A., Gupta O.P., Singh G.D., Youssouf M.S., Dhar K.L., Suri O.P.,

Suri K.A., Satti N.K., Gupta B.D., Qazi G.N. (2006) Synthesis and bronchodilator

activity of new quinazolin derivative. European Journal of Medicinal Chemistry 41.

429–43.