Chapter 8

References

Abe, T., Sakane, M., Ikoma, T., Kobayashi, M., Nakamura, S., Ochiai, N. (2008)

Intraosseous delivery of paclitaxel-loaded hydroxyapatite-alginate composite

beads delaying paralysis caused by metastatic spine cancer in rats. J. Neurosurg.

Spine 9: 502-510.

Ahad, A., Aqil, M., Kohli, K., Sultana, Y., Mujeeb, M., Ali, A. (2012) Formulation and

optimization of nanotransfersomes using experimental design technique for

accentuated transdermal delivery of valsartan. Nanomed: Nanotechnol. 8(2):

237-249.

Ahmed, F., Pakunlu, R.I., Brannan, A., Bates, F., Minko, T., Discher, D.E. (2006)

Biodegradable polymersomes loaded with both paclitaxel and doxorubicin

permeate and shrink tumors, inducing apoptosis in proportion to accumulated

drug. J. Control. Release 116: 150-158.

Ali, A.I., Jitender, M., Dinesh, K., Satish, S., Shankar, P.R., Asgar, A. (2011)

Comparative study of transfersomes, liposomes, and niosomes for topical delivery

of 5-fluorouracil to skin cancer cells: preparation, characterization, in vitro

release, and cytotoxicity analysis. Anti-cancer drugs. 22(8): 774-782.

Allen, C., Maysinger, D., Eisenberg, A. (1999) Nano-engineering block copolymer

aggregates for drug delivery. Coll. Surf. B: Biointer. 16: 3-27.

Appendino, G. (1993) Taxol(R)

(paclitaxel): historical and ecological aspects. Fitoterapia

45: 5-27.

Araujo, L.M.P.C., Thomazine, J.A., Lopez, R.F.V. (2010) Development of

microemulsions to topically deliver 5-aminolevulinic acid in photodynamic

therapy. Eur. J. Pharm. Biopharm. 75(1): 48-55.

References

-271-

Bae, Y., Jang, W.D., Nishiyama, N., Fukushima, S., Kataoka, K. (2005) Multifunctional

polymeric micelles with folate-mediated cancer cell targeting and pH-triggered

drug releasing properties for active intracellular drug delivery. Mol. Biosyst. 1:

242-250.

Baghel, U.S., Singhal, M., Gupta, M.M., Singh, H.P., Sahu, M. (2009) Analytical method

validation for tablet of phenoxymethyl penicillin potassium by RP-HPLC method.

J. Chem. Pharm. Res. 1(1): 271-275.

Bahia, A.P., Azevedo, E.G., Ferreira, L.A., Frezard, F. (2010) New insights into the

mode of action of ultradeformable vesicles using calcein as hydrophilic

fluorescent marker. Eur. J. Pharm. Sci. 39: 90-96.

Bakowsky, U., Kissel, T. (2007)

Poly (vinyl alcohol)-graft-poly(lactide-co-glycolide)

nanoparticles for local delivery of paclitaxel for restenosis treatment. J. Control.

Release 119(1): 41-51.

Bangham, A.D., Horne, R.W. (1964) Negative staining of phospholipids and their

structural modification by surface- active agents as observed in the electron

microscope. J. Mol. Biol. 8: 660-668.

Bao A., Goins B., Klipper, R., Negrete, G., Phillips, W.T. (2004) Direct 99mTc labeling

of pegylated liposomal doxorubicin (Doxil) for pharmacokinetic and non-invasive

imaging studies. J. Pharmacol. Exp. Ther. 308(2): 419-425.

Bechara, F.G., Sand, M., Hoffmann, K., Sand, D., Altmever, P., Stuker, M. (2007) Fat

tissue after lipolysis of lipomas: A histpathological and immunohistochemical

study. J. Cutan. Pathol. 34(7): 552-559.

Berrada, M., Serreqi, A., Dabbarh, F., Owusu, A., Gupta, A., Lehnert, S. (2005) A novel

non-toxic camptothecin formulation for cancer chemotherapy. Biomaterials 26:

2115-2120.

Bharadwaj, R., Yu, H. (2004) The spindle checkpoint, aneuploidy, and cancer. Oncogene

23 (11): 2016-2027.

References

-272-

Bilensoy, E., Gürkaynak, O., Dogan, A., Hincal, A. (2008) Safety and efficacy of

amphiphilic β-cyclodextrin nanoparticles for paclitaxel delivery. Int. J. Pharm.

347: 163-170.

Biswas, S., Dodwadkar, N.S., Deshpande, P.P., Torchilin, V.P. (2012) Liposomes

loaded with paclitaxel and modified with novel triphenylphosphonium-PEG-PE

conjugate possess low toxicity, target mitochondria and demonstrate enhanced

antitumor effects in vitro and in vivo. J. Control. Release 159(3): 393-402.

Bommannan, D., Potts, R.O., Guy, R.H. (1991) Examination of the effect of ethanol on

human stratum corneum in vivo using infrared spectroscopy. J. Control. Release

16(3): 299-304.

Bouwstra, J. A., Gooris, G.S. (2010) The lipid organization in human stratum corneum

model systems. Open. Derm. J. 4: 10-13.

Bouwstra, J.A., Honeywell-Nguyen, P.L. (2002) Skin Structure and mode of action of

vesicles. Adv. Drug. Del. Rev. 54(1): S41-S55.

Bouwstra, J.A., Honeywell-Nguyen, P.L., Gooris, G.S., Ponec,M. (2003) Structure of

skin barrier and its modulation by vesicular formulations. Progress in lipid res.

42:1-36.

British pharmacopeia (2009) Paclitaxel 1: 4505.

Brito, D.A., Yang, Z., Rieder, C.L. (2008) Microtubules do not promote mitotic slippage

when the spindle assembly checkpoint cannot be satisfied. J. Cell Biol. 182 (4):

623-629.

Burger, K.N., Staffhorst, R.W., De Vijlder, H.C., Velinova, M.J., Bomans, P.H.,

Frederik, P. M., De Kruijff, B. (2002) Nanocapsules: lipid-coated aggregates of

cisplatin with high cytotoxicity. Nat. Med. 8: 81-84.

Cai, S., Thati, S., Bagby, T.R., Diabw Mustafa, H., Davies, N.M., Cohen, M.S., Forrest,

M.L. (2010) Localized doxorubicin chemotherapy with a biopolymeric

nanocarrier improves survival and reduces toxicity in xenografts of human breast

cancer. J. Control. Release 146: 212-218.

References

-273-

Cavalli, R., Caputo, O., Gasco, M.R. (2000) Preparation and characterization of solid

lipid nanospheres containing paclitaxel. Eur. J. Pharm. Biopharm. 10: 305-309.

Cevc, G. (1993a) Phospholipids Handbook: Marcel Dekker, NY, Basel, Hong Kong.

215-240.

Cevc, G. (1996) Transfersomes, liposomes and other lipid suspensions on the skin:

permeation enhancement, vesicle penetration and transdermal drug delivery. Crit.

Rev. Ther. Drug Carrier Syst. 13: 257-388.

Cevc, G., Blume, G. (1992) Lipid vesicles penetrate into the skin owing to the

transdermal osmotic gradients and hydration force. Biochim. Biophys. Acta.

1104: 226-232.

Cevc, G., Blume, G., Schatzlein, A. (1997) Transfersomes mediated transepidermal

delivery improves the regiospecificity and biological activity of corticosteroids in

vivo. J. Control. Release 45: 211-226.

Cevc, G., Blume, G., Schatzlein, A., Gebauer, D., Paul, A. (1996) The skin: a pathway

for systematic treatment with patches and lipid based agent carriers. Adv. Drug

Deliv. Rev. 18: 349-378.

Cevc, G., Gebauer, D., Schatzlein, A., Blume, G. (1998) Ultraflexible vesicles

transfersomes have an extremely low pore penetration resistance and transport

therapeutic amounts of insulin across the intact mammalian skin. Biochim.

Biophys. Acta. 1368: 210-225.

Cevc, G., Schatzlein, A., Blume, G. (1995) Transdermal drug carriers: Basic properties,

optimization and transfer efficiency in the case of epicutaneously applied

peptides. J. Control. Release 36: 3-16.

Cevc, G., Schatzlein, A., Richardsen, H. (2002) Ultradeformable lipid vesicles can

penetrate the skin and other semi-permeable barriers unfragmented. Evidence

from double label CLSM experiments and direct size measurements. Biochim.

Biophys. Acta 1564: 21-30.

References

-274-

Chakravarthi, S.S., De, S., Miller, D.W., Robbinson, D.H. (2010) Comparison of anti-

tumor efficacy of paclitaxel delivered in nano- and microparticles. Int. J. Pharm.

383: 37-44.

Chandrasekhar, N.S. and Shobha Rani, R.H. (2009) Microprocessor in controlled

transdermal drug delivery of anti-cancer drugs. J. Mater. Sci. Mater. Med.

20:189-194.

Chang, R.S., Kim, J., Lee, H.Y., Han, S.-E., Na, J., Kim, K., Kwon, I.C., Kim, Y.B., Oh,

Y.-K. (2010) Reduced dose-limiting toxicity of intraperitoneal mitoxantrone

chemotherapy using cardiolipin-based anionic liposomes. Nanomed:

Nanotechnol. 6(6): 769-776.

Chapman, S.J., Walsh, A. (1990) Arch: Desmosomes, corneosomes and desquamation.

An ultra structural study of adult pig epidermis. Dermatol. Res. 282: 304-320.

Chenite, A., Chaput, C., Wang, D., Combes, C., Buschmann, M.D., Hoemann, C.D.,

Leroux, J.C., Atkinson, B.L., Binette, F., Selmani, A. (2000) Novel injectable

neutral solution of chitosan form biodegradable gels in situ. Biomaterials 21:

2155-2161.

Chenite, M., Buschmann, D., Wang, C., Kandani, N. (2001) Rheological characterization

of thermogelling chitosan/glycerophosphate solutions. Carbohydrate polymers

46: 39-47.

Chi, L.M., Wu, W.G. (1991) Mechanism of hemolysis of red blood cell mediated by

ethanol. Biochim. Biophys. Acta. 1062: 46-50.

Chun Lei, Li., Cui, J., Wang, C., Li, Y., Zhang , H.W., Wang, J.X., Li , Y.H., Zhang , L.,

Guo, W.M., Wang, Y.L. (2008) Encapsulation of mitoxantrone into Pegylated

SUVs enhances its antineoplastic efficacy. Eur. J. Pharm. Biopharm. 70: 657-

665.

Chun, C., Lee, S.M., Kim, S.Y., Yang, H.K., Song, S.C. (2009) Thermosensitive poly

(organophosphazene)-paclitaxel conjugate gels for antitumor applications.

Biomaterials 30: 2349-2360.

References

-275-

Cochran, M.C., Eisenbrey, J., Ouma, R.O., Soulen, M., Wheatley, M.A. (2011)

Doxorubicin and paclitaxel loaded microbubbles for ultrasound triggered drug

delivery. Int. J. Pharm. 414(1-2): 161-170.

Cohen, S., Lobel, E., Trevgoda, A., Peled, Y. (1997) A novel in situ-forming ophthalmic

drug delivery system for alginates undergoing gelation in the eye. J. Control.

Release 44: 201-208.

Corsini, E., Galli, C.L. (1986) Cytokines and irritant contact dermatitis. Toxicol. Lett.

102/103: 277-282.

Cosco, D., Paolino, D., Muzzalupo, R., Celia, C., Citraro, R., Caponio, D., Picci, N.,

Fresta, M. (2009) Novel PEG-coated niosomes based on bola-surfactant as drug

carriers for 5-fluorouracil. Biomed. Microdevices 11(5): 1115-1125.

Crompton, K.E., Prankerd, R.J., Paganin, D.M., Scott, T.F., Horne, M.K., Finkelstein,

D.I., Gross, K.A., Forsythe, J.S. (2005) Morphology and gelation of

thermosensitive chitosan hydrogels. Biophys. Chem. 117: 47-53.

Crosasso, P., Ceruti, M., brusa, P., Arpicco, S., Dosio, F., Cattel, L. (2000) Preparation,

characterization and properties of sterically stabilized paclitaxel-containing

liposomes. J. Control. Release 63(1-2): 19-30.

Curic, N.D., Grafe, S., Albrecht, V., Fahr, A. (2008) Topical application of temoporfin-

loaded invasomes for photodynamic therapy of subcutaneously implanted tumors

in mice: A pilot study. J. Photochem. Photobiol. B 91: 41-50.

De Mario, M.D., Ratain, M.J. (1998) Oral chemotherapy: rationale and future directions.

J. Clin. Oncol. 16: 2557-2567.

Desai, N., Trieu, V., Yao, Z., Louie, L., Ci, S., Yang, A., Tao, C., De, T., Beals, B.,

Dykes, D., Noker, P., Yao, R., Labao, E., Hawkins, M., Soon-Shiong, P. (2006)

Increased antitumor activity, intratumor paclitaxel concentrations and endothelial

cell transport of Cremophor-free, albumin-bound paclitaxel, ABI-007, compared

with Cremophor-based paclitaxel. Clin. Cancer Res. 12: 1317-1324.

References

-276-

Desai, P.B., Duan, J. Z., Kouzi, S. (1998) Human liver microsomal metabolism of

pacliaxel and drug interactions. Eur J Drug Metab Pharmacokineict 23(3): 417-

424.

Dhanikula, A.B., Panchagnula, R. (1999) Localized paclitaxel delivery. Int. J. Pharm.

183:85-100

Dhanikula, A.B., Panchagnula, R. (2004) Development and characterization of

biodegradable chitosan films for local delivery of paclitaxel. AAPS J. 6(3): 1-12.

Dong, Y., Feng, S.S. (2004) Methoxy poly(ethylene glycol)-poly(lactide) (MPEG-PLA)

nanoparticles for controlled delivery of anticancer drugs. Biomaterials 25: 2843-

2849.

Dong, Y., Zhang, Z., Feng, S.S. (2008) d-alpha-Tocopheryl polyethylene glycol 1000

succinate (TPGS) modified poly(l-lactide) (PLLA) films for localized delivery of

paclitaxel. Int. J. Pharm. 350: 166-171.

Draize, J., Woodard, G., Calvery, H. (1944) Methods for the study of irritation and

toxicity of substance applied to the skin and mucous membranes. J. Pharmacol.

Exper. Therap. 82: 377-390.

Dreis, S., Rothweiler, F., Michaelis, M., Cinatl, J. J., Kreuter, J., Langer, K. (2007)

Preparation, characterization and maintenance of drug efficacy of doxorubicin-

loaded human serum albumin (HSA) nanoparticles. Int. J. Pharm. 341: 207-214.

Drummond, D.C., Meyer, O., Hong, K., Kirpotin, D.B., Papahadjopoulos (1999)

Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors.

Pharm. Rev. 51(4): 691-744.

Du Plessis, J., Ramachandran, C., Weiner, N., Müller, D.G. (1994) The influence of

particle size of liposomes on the disposition of drug into the skin. Int. J. Pharm.

103: 277-282.

Dubey, V., Mishra, D., Asthana, A., Jain, N.K. (2006) Transdermal delivery of a pineal

hormone: Melatonin via elastic liposomes. Biomaterials 27: 3491-3496.

References

-277-

Egbaria, K., Ramachandran, C., Weiner, N. (1990) Topical delivery of cyclosporin A:

evaluation of various formulations using in vitro diffusion studies in hairless

mouse skin. Skin Pharmacol. 321-328.

El Maghraby, G.M.M., Williams, A.C., Barry, B.W. (1999) Skin delivery of oestradiol

from deformable and traditional liposomes: Mechanistic studies. J. Pharm.

Pharmacol. 51: 1123-1134.

El Maghraby, G.M.M., Williams, A.C., Barry, B.W. (2000) Skin delivery of oestradiol

from lipid vesicles: Importance of liposome structure. Int. J. Pharm. 204: 159-

169.

El Maghraby, G.M.M., Williams, A.C., Barry, B.W. (2001) Skin delivery of 5-

fluorouracil from ultra deformable and standard liposomes in vitro. J. Pharm.

Pharmacol. 53: 1069-1077.

El Meshad, A.N., Tadros, M.I. (2011) Transdermal delivery of an anti-cancer drug via

w/o emulsions based on alkyl polyglycosides and lecithin: Design,

characterization, and in vivo evaluation of the possible irritation potential in rats.

AAPS. Pharm. Sci. Tech. 12(1):1-9.

Elias, P.M., Cooper, E.R., Korc, A., Brown, B.E. (1981) Percutaneous transport in

relation to stratum corneum structure and lipid composition. J. Invest. Dermatol.

76, 297-301.

Elisseeff, J., Anseth, K., Sims, D., Mcintosh, W., Randolph, M., Langer, R. (1999)

Transdermal photopolymerization for minimally invasive implantation. Proc. Nat.

Acad. Sci. U.S.A. 96: 3104-3107.

Elstad, N.L., Fowers, K.D. (2009) OncoGel (ReGel/paclitaxel)-clinical applications for a

novel paclitaxel delivery system. Adv. Drug Del. Rev. 61: 785-794.

Emmanuel, A.H., Patrick, L.S., Christine, A., Micheline, P.M. (2007) Impact of

intraperitoneal, sustained delivery of paclitaxel on the expression of P-

glycoprotein in ovarian tumors. J. Control. Release 117: 20-27.

References

-278-

Emmanuel, A.H., Vessela, V., Christine, A., Micheline, P.M. (2005) In vitro and in vivo

characterization of a novel biocompatiable polymer-lipid implants system for the

sustained delivery of paclitaxel. J. Control. Release 104: 181-191.

Ermolaeva, L.A., Dubskaya, T.Y., Fomina, T.I., Vetoshkina, T.V., Goldberg, V.E. (2008)

Toxic effect of an antitumor drug paclitaxel on morphofunctional characteristics

of the liver in rats. Bull. Exp. Bio. Med. 145: 225-228.

Essa, E.A, Bonner, M.C., Barry, B.W. (2002) Iontophoretic estradiol skin delivery and

tritium exchange in ultradeformable liposomes. Int. J. Pharm. 240: 55-66.

Fang, J.Y., Lin, H.H., Hsu, L.R., Tsai, Y.H. (1997) Characterization and stability of

various liposome-encapsulated enoxacin formulations. Chem. Pharm. Bull. 45:

1504-1509.

Feng, S.S., Mu, L., Chen, B.H., Daniel, P. (2002) Polymeric nanospheres fabricated with

natural emulsifiers for clinical administration of an anticancer drug paclitaxel.

Material Sci. Eng. C20: 85-92.

Ferlay, J., Shin, H.R., Bray, F., Forman, D., Mathers, C., Parkin, D.M. (2010) Estimates

of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer 127:

2893-2917.

Fernandez, C.B., Font, A.F., Merino, V., Diaz, D.C., Barroeta, M.E., Castellano, A.L.,

Diaz, M.C. (2011) Elastic vesicles of sumatriptan succinate for transdermal

administration: Characterization and in vitro permeation studies. J. Liposome

Res. 21(1): 55-59.

Floyd, A.G. (1999) Top ten considerations in the development of parenteral emulsions.

Pharm. Sci. Techl. Today 2: 134-143.

Folch, J., Lees, M., Sloane-Stanley, G.H. (1957) A simple method for the isolation and

purification of total lipids from animal tissues. J. Biol. Chem. 226:497-502.

Fonseca, C., Simoes, S., Gaspar, R. (2002) Paclitaxel-loaded PLGA nanoparticles:

Preparation, physicochemical characterization and in vitro anti-tumoral activity.

J. Control. Release 83: 273-286.

References

-279-

Frairia, M.R. Gascoc, M. Eandi, Zara, G.P. (2004) Cytotoxicity of anticancer drugs

incorporated in solid lipid nanoparticles on HT-29 colorectal cancer cell line. Eur.

J. Pharm. Biopharm. 58: 673-680.

Fung, L.K., Saltzman, W.M. (1997) Polymeric implants for cancer chemotherapy. Adv.

Drug Deli. Rev. 26(2-3): 209-230.

Garcion, E., Lamprecht, A., Heurtault, B., Paillard, A., Aubert-Pouessel, A.,

Denizot,Philippe Menei, B., Benoıt, J.P. (2006) A new generation of anticancer,

drug-loaded, colloidal vectors reverses multidrug resistance in glioma and reduces

tumor progression in rats. Mol. Cancer Ther. 5(7): 1710-1722.

Garg, T., Jain, S., Singh, H., Sharma, A., Tiwary, A.K. (2008) Elastic liposomal

formulation for sustained delivery of antimigraine drug: In vitro characterization

and biological evaluation. Drug Dev. Ind. Phar. 34(10): 1100-1110.

Garidel, P. (2002) Mid-FTIR-Microspectroscopy of stratum corneum single cells and

stratum corneum tissue. Phys. Chem. Chem. Phys. 4: 5671-5677.

Gariepy, E.R., Leclair, G., Hildgen, P., Gupta, A., Leroux, B. (2002) Thermo sensitive

chitosan-based hydrogel containing liposomes for the delivery of hydrophilic

molecules. J. Control. Release 82: 373-383.

Gelderblom, H. (2001) Cremophor EL the drawbacks and advantages of vehicle selection

for drug formulation. Eur. J. Cancer 37(13): 1590-1598.

Gelfuso, G.M., Figueiredo, F.V., Gratieri, T., Lopez, R.F.V. (2008) The effect of pH and

ionic strength on topical delivery of a negatively charged porphyrin (TPPS4). J.

Pharm. Sci. 97: 4249-4257.

Gelfuso, G.M., Gratieri, T., Souza, J.G., Thomazine, J.A., Lopez, R. F.V. (2011) The

influence of positive or negative charges in the passive and iontophoretic skin

penetration of porphyrins used in photodynamic therapy. Eur. J. Pharm.

Biopharm. 77(2): 249-256.

Gerald, J.F., Robert, M.S. (2003) Pharmacokinetics of paclitaxel-containing liposomes in

rat. APPS Pharm. Sci. Tech. 5(4):90-100.

References

-280-

Gilbert, J.C., Richardson, J.L., Davies, M.C., Palin, K.J., Hadgraft, J. (1987) The effect of

solutes and polymers on the gelation properties of pluronic F-127 solutions for

controlled drug delivery. J. Control. Release 5: 113-118.

Gill, KK., Nazzal, S., Kaddoumi, A. (2011) Paclitaxel loaded PEG (5000)-DSPE micelles

as pulmonary delivery platform: formulation characterization, tissue distribution,

plasma pharmacokinetics, and toxicological evaluation. Eur. J. Pharm.

Biopharm. 79(2): 276-284.

Glavas-Dodov, M., Kumba-Radzi, E.F., Goracinova, K., Calis, S., Simonoska, M.,

Hincal, A. (2003) 5-Fluorouracil in topical liposome gels for anticancer treatment-

Formulation and evaluation. Acta. Pharm. 53: 241-250.

Golden, G.M., Guzek, D.B., Harris, R.R., McKie, J.E., Potts, R.O. (1986) Fourier

Transform Raman Spectroscopy. J. Invest. Dermatol. 86: 255-259.

Golden, G.M., McKie, J.E., Potts, R.O. (1987) Role of stratum corneum lipid fluidity in

transdermal drug flux. J. Pharm. Sci. 76: 25-28.

Gompper, G., Kroll, D.M. (1995) Driven transport of fluid vesicles through narrow pores.

Phys. Rev. E-52: 4198-4208.

Gottesman, M.M. (2002) Mechanisms of cancer drug resistance. Annu. Rev. Med. 53:

615-627.

Gradishar, W.J., Tjulandin, S., Davidson, N., Shaw, H., Desai, N., Bhar, P., Hawkins, M

(2005) Phase III trial of nanoparticle albumin bound paclitaxel compared with

polyethylated castor oil based paclitaxel in women with breast cancer. J. Clin.

Oncology 23 (31): 7794-7803.

Gregoriadis, G. (1976a) The carrier potential of liposomes in biology and medicine. (Part

one of two parts) N. Engl. J. Med. 295: 704-710.

Gregoriadis, G. (1976b) The carrier potential of liposomes in biology and medicine. (Part

two of two parts) N. Engl. J. Med. 295: 765-770.

Guo, J., Ping, Q., Sun, G., Jiao, C. (2000) Lecithin vesicular carriers for transdermal

delivery of cyclosporine A. Int. J. Pharm. 194: 201-207.

References

-281-

Gupta, P.N., Mishra, V., Rawat, A., Dubey. P.K., Mahor, S., Jain, S., Chatterji, D.P.

Vyas, S.P. (2005) Non-invasive vaccine delivery in transfersomes, niosomes and

liposomes: a comparative study. Int. J. Pharm. 293: 73-82.

Hamidi, M., Azadi, A., Raei, P. (2008) Hydrogel nanoparticles in drug delivery. Adv.

Drug Deliv. Rev. 60: 1638-1649.

Hamilton, M.A., Russo, R.C., Thurston, R.C. (1977) Trimmed Spearman-karber method

for estimating median lethal concentration in toxicity bioassays. Env. Sci.

Technol. 7: 714-719.

Han, H.D., Chol, M.S., Hwang, T., Song, C.K., Seong, H., Kim, T.W., Choi, H.S., Shin,

B.C. (2006) Hyperthermia-induced anti-tumor activity of thermosensitive

polymer modified temperature -sensitive liposomes. J. Pharm. Sci. 95(9): 1909-

1917.

Han, H.D., Shin, B.C., Choi, H.S. (2006) Doxorubicin-encapsulated thermosensitive

liposomes modified with poly(N-isopropylacrylamide-co-acrylamide): Drug

release behavior and stability in the presence of serum. Eur. J. Pharm.

Biopharm. 62(1): 110-116.

Hana, X., Liua, J., Liua, M., Xiea, C., Zhana, C., Gua, B., Liua, Y., Fenga, L., Lua, W.

(2009) 9 NC-loaded folate-conjugated polymer micelles as tumor targeted drug

delivery system: Preparation and evaluation in vitro. Int. J. Pharm. 372: 125-131.

Hao, Y.L., Deng, Y.J., Chen, Y., Wang, X.M., Jun, H., Zhong, S. X.B. (2005) In vitro

and in vivo studies of different liposomes containing topotecan. Arch. Pharm.

Res. 28: 626-635.

Haq, M.I., Smith, E., John, D.N., Kalavala, M., Edwards, C., Anstey, A., Morrissey, A.,

Birchall, J.C. (2009) Clinical administration of microneedles: skin puncture, pain

and sensation. Biomed. Microdevices 11: 35-47.

Heldman, A.W., Cheng, L., Jenkins, G.M., Heller, P.F., Kim, D.W., Ware Jr, M., Nater,

C., Hruban, R.H . (2001) Paclitaxel stent coating inhibits neointimal hyperplasia

References

-282-

at 4 weeks in a porcine model of coronary restenosis. Circulation 103 (18): 2289-

2295.

Heney, M., Alipour, M., Vergidis, D., Omri, A., Mugabe, C., Thng, J., Suntres, Z. (2010)

Effectiveness of liposomal paclitaxel against MCF-7 breast cancer cells. Can. J.

Physiol. Pharmacol. 88: 1172-1180.

Herai, H., Gratieri, T., Thomazine, J.A., Bentley, M.V.L.B., Lopez, R.F.V. (2007)

Doxorubicin skin penetration from monoolein-containing ropylene glycol

formulations. Int. J. Pharm. 329 (1-2): 88-93.

Herdeg, C., Oberhoff, M., Baumbach, A., Blattner, A., Kuttner, A., Schroder, S., Haase,

K.K., Karsch, K.R. (1999) Visualization and comparison of drug effects after

local paclitaxel delivery with different catheter types. Basic Res. Cardiol. 94:

454-463.

Higashi, S., Tabata, N., Kondo, K. H., Maeda, Y., Shimizu, M., Nakashima, T.,

Setoguchi, T. (1999) Size of lipid microdroplets effects results of hepatic arterial

chemotherapy with an anticancer agent in water-in-oil-in-water emulsion to

hepato-cellular carcinoma. J. Pharmacol. Exp. Ther. 289: 816-819.

Ho, E.A., Soo, P.L., Allen, C., Miller, M.P. (2007) Impact of intraperitoneal, sustained

delivery of paclitaxel on the expression of P-glycoprotein in ovarian tumors. J.

Control. Release 117: 20-27.

Ho, E.A., Vassileva, V., Allen, C., Miller, M.P. (2005) In vitro and in vivo

characterization of a novel biocompatible polymer-lipid implant system for the

sustained delivery of paclitaxel. J. Control. Release 104(1): 181-191.

Hofer, C., Göbel, R., Deering, P., Lehmer, A., Breul, J. (1999) Formulation of

interleukin-2 and interferon-alpha containing ultradeformable carriers for

potential transdermal application. Anticancer Res. 19: 1505-1507.

Hofer, C., Hartung, R., Gobel, R., Deering, P., Lehmer, A., Breul, J. (2000) New

ultradeformable drug carriers for potential transdermal application of interleukin-

References

-283-

2 and interferon-alpha: Theoretical and practical aspects. World J. Surg. 24:

1187-1191.

Hofer, C., Randenborgh, H.V., Lehmer, A., Hartung, R., Breul. J. (2004) Transcutaneous

IL-2 uptake mediated by transfersomes depends on concentration and fractionated

application. Cytokine 25: 141-146.

Honeywell-Nguyen, P.L., Bouwstra, J.A. (2003) The in vitro transport of pergolide from

surfactant-based elastic vesicles through human skin: a suggested mechanism of

action. J. Control. Release 86: 145-156.

Honeywell-Nguyen, P.L., de Graaff, A.M., Wouter Groenink, H.W., Bouwstra, J.A.

(2002a) The in vivo and in vitro interactions of elastic and rigid vesicles with

human skin. Biochim. Biophys. Acta. 1573: 130-140.

Honeywell-Nguyen, P.L., Frederik, P.M., Bomans P.H.H., Junginger, H.E. Bouwstra,

J.A. (2002) Transdermal delivery of pergolide from surfactant based elastic and

rigid vesicles: Characterization and in vitro transport studies. Pharm. Res. 19 (7):

991-997.

Hunter, W.L., Burt H.M., Machan, L. (1997) Local delivery of chemotherapy: a

supplement to existing cancer treatments. A case for surgical pastes and coated

stents. Adv. Drug. Deliv. Rev. 26: 199-207.

Hureaux, J., Lagarce, F., Gagnadoux, F., Marie-Christine, R., Moal, V., Urban, T.,

Benoit, J.P. (2010) Toxicological study and efficacy of blank and paclitaxel-

loaded lipid nanocapsules after i.v. administration in mice. Pharm. Res. 27(3):

421-430.

Jain, A., Agarwal, A., Majumder, S., Lariya, N., Khaya, A., Himanshu, A., Majumdar, S.,

Agrawal, G.P. (2010) Mannosylated solid lipid nanoparticles as vectors for site-

specific delivery of an anti-cancer drug. J. Control. Release 148(3): 359-367.

Jain, N.K., Mishra, D., Garg, M., Dubey, V., Jain, S. (2006) Elastic liposomes mediated

transdermal delivery of an anti-hypertensive agent: propranolol hydrochloride. J.

Pharm. Sci. 96: 145-155.

References

-284-

Jain, R. K. (1994) Barriers to drug delivery in solid tumors. Sci. Am. 271: 58-65.

Jain, S., Jain, N., Bhadra, D., Jain, N.K. (2005) Transdermal delivery of an analgesic

agent using elastic liposomes: preparation, characterization and performance

evaluation. Curr. Drug Deliv. 2: 1-11.

Jain, S., Jain, N., Bhadra, D., Tiwary, A.K., Jain, N.K. (2005b) Transdermal delivery of

an analgesic agent using elastic liposomes: preparation, characterization and

performance evaluation. Curr. Drug Deliv. 2(3): 223-233.

Jain, S., Jain, N.K., Tiwary, A.K. (2008) PEGylated elastic liposomal formulation for

lymphatic targeting of zidovudine. Curr. Drug. Deliv. 5: 275-281.

Jain, S., Jain, P., Umamaheshwari, R.B., Jain, N.K. (2003a) Transfersomes-A novel

vesicular carrier for enhanced transdermal delivery: development,

characterization, and performance evaluation. Drug Dev. Ind. Pharm. 29: 1013-

1026.

Jain, S., Sapre, R., Tiwary, A.K. Jain, N.K. (2005a) Proultraflexible lipid vesicles for

effective transdermal delivery of levonorgestrel: Development, characterization,

and performance evaluation. AAPS Pharm. Sci. Tech. 6: E513-522.

Jain, S., Sapre, R., Umamaheshwari, R.B. Jain, N.K. (2003b) Protransfersomes for

effective transdermal delivery of levonorgestrel preparation and in vitro

characterization. Int. J. Pharm. Sci. 65: 152-161.

Jain, S., Tiwary, A.K., Jain, N.K. (2006) Sustained and targeted delivery of anti-HIV

agent using elastic liposomal formulation: Mechanism of action. Curr. Drug

Deliv. 3(2): 157-166.

Jain, S., Tiwary, A.K., Jain, N.K. (2008) PEGylated elastic liposomal formulation for

lymphatic targeting of zidovudine. Curr. Drug Deliv. 5: 275-281.

Jauhari, S., Dash, A.K. (2006) Mucoadhesive in situ gel delivery system for paclitaxel.

AAPS Pharm. Sci. Tech. 7(2): E154-E159.

Jemal, A., Siegel, R., Xu, J., Ward, E. (2010) Cancer statistics, CA. Cancer J. Clin.

60(144): 277-300.

References

-285-

Jemel, F. Bray., J, Ferlay., E. Ward, D, Forman. (2011) Global cancer statistics. Cancer

J. Clin. 61: 69-90.

Jeong, B., Bae, Y.H., Lee, D.S., Kim, S.W. (1997) Biodegradable block copolymers as

injectable drug-delivery systems. Nature 388: 860-862.

Johnston, T.P., Punjabi, M.A., C.J. Froelich (1992) Sustained delivery of interleukin-2

from a poloxamer 407 gel matrix following intraperitoneal injection in mice.

Pharm. Res. 9: 425-434.

Jonkman-deVries, J.D., Flora, K.P., Bult, A., Beijnen, J.H. (1996) Pharmaceutical

development of investigational anticancer agents for parenteral use - a review.

Drug Dev. Ind. Pharm. 22: 475-494.

Jubo, L., Lee, H., Huesca, M., Young, A., Allen, C. (2006) Liposome formulation of a

novel hydrophobic aryl-imidazole compound for anti-cancer therapy. Cancer

Chemother. Pharmacol. 58: 306-318.

Jumaa, M., Muller, B.W. (2000) Lipid emulsions as a novel system to reduce the

hemolytic activity of lytic agents: mechanism of the protective effect. Eur. J.

Pharm. Sci. 9: 285-290.

Jung, T., Kamm W., Breitenbach A., Kaiserling E., Xiao J.X., Kissel T. (2000)

Biodegradable nanoparticles for oral delivery of peptides: is there a role for

polymers to affect mucosal uptake? Eur. J. Pharm. Biopharm. 50: 147-160.

Kaisera, N., Kimpfler, A., Massing, U., Burger, A.M., Fiebig, H.H., Brandl, M.,

Schubert, R. (2003) 5-Fluorouracil in vesicular phospholipid gels for anticancer

treatment: entrapment and release properties. Int. J. Pharm. 256: 123-131.

Kaminskas, L.M., Kelly, B.D., McLeod, V.M., Sberna, G., Owen, D.J., Boyd,

B.J., Porter, C.J. (2011) Characterization and tumour targeting of PEGylated

polylysine dendrimers bearing doxorubicin via a pH labile linker. J. Control.

Release152 (2): 241-248.

References

-286-

Kan, P., Chen, Z.B., Lee, C.J., Chu, I.M. (1999) Development of nonionic surfactant/

phospholipids o/w emulsion as a paclitaxel delivery system. J. Control. Release

58: 271-278.

Kang, B.K., Kang, S., Kim, S.H., Jeong, S.Y., Kim, M.S., Cho, S.H., Lee, H.B., Khang,

G. (2004) Controlled release of paclitaxel from micro emulsion containing PLGA

and evaluation of anti-tumor activity in vitro and in vivo. Int. J. Pharm. 286: 147-

156.

Kataoka, K., Harada, A., Nagasaki, Y. (2001) Block copolymer micelles for drug

delivery: design, characterization and biological significance. Adv. Drug Deliv.

Rev. 47: 113-131.

Kataoka, K., Kwon, G.S., Yokoyama, M., Okano, T., Sakurai, Y. (1993) Block

copolymer micelles as vehicles for drug delivery. J. Control. Release 24: 119-

132.

Kaur N, Puri R, Jain S. (2010) Drug cyclodextrin -Vesicles dual carrier approach for

skin targeting of anti-acne agent. APPS PharmSci. Tech. 11:528–537.

Kaur, N., Puri, R., Jain, S. (2010) Drug cyclodextrin-vesicles dual carrier approach for

skin targeting of anti-acne agent. APPS Pharm. Sci. Tech. 11: 528-537.

Khandavilli, S., and Panchagnula, R. (2007) Nanoemulsions as versatile formulations for

paclitaxel delivery: Peroral and dermal delivery studies in rats. J. of Invest. Derm.

127: 154-162.

Khurana, S., Utreja, P., Tiwary, A.K., Jain, S. (2009) Nanostructured lipid carriers and

their application in drug delivery. Int. J. Biomedical Eng. Technol. 2: 152-171.

Kievit, F.M., Wang, F.Y., Fang, C., Mok, H., Wang, K., Silber, J.R., Ellenbogen, R.G.,

Zhang, M. (2011) Doxorubicin loaded iron oxide nanoparticles overcome

multidrug resistance in cancer in vitro. J. Control. Release 152: 76-83.

Kilicay, E., Demirbilek, M., Turk, M., Guven, E., Hazer, H., Denkbas, E.B. (2011)

Preparation and characterization of poly(3-hydroxybutyrate-co-3-

References

-287-

hydroxyhexanoate) (PHBHHX) based nanoparticles for targeted cancer therapy.

Eur. J. Pharma. Sci. 44: 310-320.

Kim, A., Lee, E.H., Choi, S.H., Kim, C.K. (2004) In vitro and in vivo transfection

efficiency of a novel ultradeformable cationic liposome. Biomaterials 25: 305-

313.

Kim, J.H., Bae, S.M., Na, M.H., Shin, H., Yang, Y.J., Min, K.H., Choi, K.Y., Kim, K.,

Park, R.W., Kwon, I.C., Lee, B.H., Hoffman, A.S., Kim, I.S. (2012) Facilitated

intracellular delivery of peptide-guided nanoparticles in tumor tissues. J. Control.

Release 157 (3): 493-499.

Kim, M.K., Chung, S.I., Lee, M.H., Shim, C.K. (1998) Delivery of hydrocortisone from

liposomal suspensions to the hairless mouse skin following topical application

under non-occlusive and occlusive conditions. J. Microencapsulation 15: 21-29.

Kim, S.C., Kim, D.W., Shim, Y.H, Bang, J.S., Oh H.S., Kim S.W., Seo, M.H. (2001) In

vivo evaluation of polymeric micellar paclitaxel formulation: toxicity and

efficacy. J. Control. Release 72: 191-202.

Kim, Y.C., Park, J.H., Ludovice, P.J., Prausnitz, M.R. (2008) Synergistic enhancement of

skin permeability by N-lauroylsarcosine and ethanol. Int. J. Pharm. 352(1-2):

129-138.

Kirjavainen, M., Monkkonen, J., Saukkosaari, M., Valjakka-Koskela, R., Kiesvaara, J.,

Urtti, A. (1999) Phospholipids effect stratum corneum lipid bilayer fluidity and

drug partitioning into the bilayers. J. Control. Release 58(2): 207-214.

Kirjavainen, M., Urtti, A., Jaaskelainen, I., Suhonen, T.M., Paronen, P., Valjakka-

Koskela, R., Monkkonen, J. (1996) Interaction of liposomes with human skin in

vitro: the influence of lipid composition and structure. Biochim. Biphys. Acta.

1304: 179-189.

Klein-Szanto, A.J. (1992) Carcinogenic effects of chemotherapeutic compounds. Prog.

Clin. 374: 167-174.

References

-288-

Koudelka, S., Knotigova, P.T., Masek, J., Korvasova, Z., Skrabalova, M., Plockova, J.,

Barthedyova, E., Turanek, J. (2009) Liposomes with high encapsulation capacity

for paclitaxel: preparation, characterization and in vivo anti cancer effect.

J. Pharm. Sci. 99: 2309-2319.

Kramer, I., Heuser, A. (1995) Paclitaxel pharmaceutical and pharmacological issues.

Eur. Hosp. Pharm. 1: 37-41.

Kreuter, J. (2007) Nanoparticles-a historical perspective. Int. J. Pharm. 331: 1-10.

Kupper, T.S. (1990) Role of epidermal cytokines, in: J.J. Oppenheim, E.M. Shevach

(Eds.),: The Role of Cells and Cytokines in Immunity and Inflammation, Oxford

University Press, New York, , pp. 285-305.

Kuttan, G., Vasudevan, D.M., Kuttan, R. (1990) Effect of a preparation from viscum

album on tumour development in vitro and in mice. J. Ethnopharmacol. 29: 35-

41.

Kwon, G. S., Suwa, S., Yokoyama, M., Okano, T., Sakurai, Y., Kataoka, K. (1994)

Enhanced tumor accumulation and prolonged circulation times of micelle-forming

poly(ethylene oxide-aspartate) block copolymer-Adriamycin conjugate.

J. Control. Release 29: 17-23.

Lacoeuille, F., Hindre, F., Moal, F., Roux, J., Passirani, C., Couturier, O., Cales, P., Le

Jeune, J.J., Lamprecht, A., Benoit. J.P. (2007) In vivo evaluation of lipid

nanocapsules as a promising colloidal carrier for paclitaxel. Int. J. Pharm. 344(1-

2): 143-149.

Lasch, J., Laub, P., Woblrab, W. (1991) How deep do intact liposomes penetrate into

human skin? J. Control. Release 18: 55-58.

Lashmar, U.T., Hadgraft, J., Thomas, J. (1989) Topical application of penetration

enhancers to the skin of nude mice: a histopathological study. J. Pharm.

Pharmacol. 41 (2): 118-121.

Lavasanifar, A., Sanuel, J., Kwon, G. (2002) Poly(ethylene oxide)-block-poly (L-amino

acid) micelles for drug delivery. Adv. Drug Deliv. Rev. 54: 169-190.

References

-289-

Lee, S., Yun, M.H., Jeong, S.W., Hoon, C., Kim, J.Y., Seo, M.H., Pai, C.M., Kim, S.O.

(2011) Development of docetaxel-loaded intravenous formulation, Nanoxel-PM™

using polymer-based delivery system. J. Control. Release 155(2): 262-271.

Lee, S.C., Kim, C., Kwon, Chung, H., Jeong, S.Y. (2003) Polymeric micelles of poly(2-

ethyl-2-oxazoline)-block-poly(epsilon-caprolactone) copolymer as a carrier for

paclitaxel. J. Control. Release 89: 437-446.

Li, X., Kong, X., Zhang, J., Wang, Y., Shi, S., Guo, G., Luo, F., Zhao, X., Wei, Y., Qian,

Z. (2011) A novel composite hydrogel based on chitosan and inorganic phosphate

for local delivery of camptothecin nanocolloids. J. Pharm. Sci. 100: 232-241.

Li, X.Y., Kong, X.Y., Wang, X.H., Shi, S., Guo, G., Luo, F., Zhao, X., Wei, Y., Qian, Z.

(2010) Gel-sol-gel thermo-gelation behavior study of chitosan-inorganic

phosphate solutions. Eur. J. Pharm. Biopharm. 75: 388-392.

Li., C.L., Cui, J., Wang, C., Li, Y., Zhang , H.W., Wang, J.X., Li , Y.H., Zhang, L.,

Guo, W.M., Wang, Y.L. (2008) Encapsulation of mitoxantrone into Pegylated

SUVs enhances its antineoplastic efficacy. Eur. J. Pharm. Biopharm. 70: 657-

665.

Liang, Y., Qiao, Y., Guo, S., Wang, L., Zhai, Y., Xie, C., Hu, R., Deng, L., Dong, A.

(2012) Investigation on injectable, thermally and physically gelable poly(ethylene

glycol)/poly(octadecanedioic anhydride) amphiphilic triblock co-polymer

nanoparticles. J. Biomater. Sci. Polym. Ed. 23(1-4): 465-482.

Lichtenberger, L.M., Graziani, L.A., Dial, E.J., Butler, B.D., Hills, B.A. (1983) Role of

surface-active phospholipids in gastric cytoprotection. Science 219: 1327-1329.

Lin, H.H., Cheng, Y.L. (2001) In situ thermoreversible gelation of block and star

copolymers of poly(ethylene glycol) and poly(N-isopropylacrylamide) of varying

architectures. Macromolecules 34: 3710-3715.

Lin, X., Deng, L., Xu, Y., Dong, A. (2012) Thermosensitive in situ hydrogel of paclitaxel

conjugated poly (ε-caprolactone)-poly(ethylene-glycol)- poly (ε-caprolactone).

Soft Matter 12(8): 3470-3477.

References

-290-

Liu, X., Sun, J., Chen, X., Wang, S., Scot, H., Zhan, X., Zhan, Q. (2012)

Pharmacokinetics, tissue distribution and anti-tumour efficacy of paclitaxel

delivered by polyvinylpyrrolidone solid dispersion. J. Pharm. Pharmacol. 775-

782.

Liu, Z., Chen, K., Davis, C., Sherlock, S., Cao, Q., Chen, X., Dai, H. (2008) Drug

delivery with carbon nanotubes for in vivo cancer treatment. Cancer Res. 68:

6652-6660.

Lo, J.T., Chen, B.H., Lee, T.M., Han, J, Li, J.L. (2009) Self emulsifying o/w formulations

of paclitaxel prepared from mixed nonionic surfactants. J. Pharm. Sci. 99 (5):

2320-2332.

Lopez, O., de la Maza, A., Coderch, L., Lopez-Lglesias, C., Wehrli, E., Parra, J.L. (1998)

direct formation of mixed micelles in the solubilization of phospholipid liposomes

by Triton X-100. FEBS Lett. 426(3): 314-318.

Lowenthal, R.M., Eaton, K. (1996) Toxicity of chemotherapy. Oncol. Clin. North Am.

10: 967-990.

Lu, B., Xiong, S.B., Yang, H., Yin, X.D., Zhao, R.B. (2006) Mitoxantrone-loaded BSA

nanospheres and chitosan nanospheres for local injection against breast cancer

and its lymph node metastases II. Tissue distribution and pharmacodynamics. Int.

J. Pharm. 307: 175-181.

Lu, J., Liong, M., Zink, J.I., Tamanol, F. (2007) Mesoporous silica nanoparticles as a

delivery system for hydrophobic anti-cancer drugs. Small 3: 1341-1346.

Luo, X., Xie, C., Wang, H., Liu, C., Yan, S., Li, X. (2012) Antitumor activities of

emulsion electrospun fibers with core loading of hydroxyl camptothecin via

intratumoral implantation. Int. J. Pharm. 425(1-2): 19-28.

Mackay, H.J., Provencheur, D., Heywood, M., Tu, D., Eisenhauer, E.A., Oza, A.M.,

Meyer, R. (2011) Phase II/III study of intraperitoneal chemotherapy after

neoadjuvant chemotherapy for ovarian cancer. Curr. Oncol. 18: 84-90.

References

-291-

Maestrelli, F., González-Rodríguez, M.L., Rabasco, A.M., Ghelardini, C., Mura, P.

(2010) New “drug-in cyclodextrin-in deformable liposomes” formulations to

improve the therapeutic efficacy of local anaesthetics. Int. J. Pharm. 395: 222-

231.

Mahdi, E.S., Sakeena, M.H.F., Abdulkarim, M.F., Abdullah, G.Z., Sattar, M.A., Noor,

A.M. (2011) Effect of surfactant and surfactant blends on pseudo ternary phase

diagram behavior of newly synthesized palm kernel oil esters. Drug Des. Devel.

Ther. 5: 311-323.

Mayer, L.D., Tai, L.C., Ko, D.S., Masin, D., Ginsberg, R.S., Cullis, P.R., Bally, M.B.

(1989) Influence of vesicle size, lipid composition and drug-to-lipid ratio on the

biological activity of liposomal doxorubicin in mice. Cancer Res. 49: 5922-5930.

Mendelsohn, R., Chen, H.C., Rerek, M.E., Moore, D.J. (2003) Infrared

microspectroscopic imaging maps the spatial distribution of exogenous molecules

in skin. J. Biomed. Opt. 8(2): 185-190.

Meyer, J.S. (1981) Growth and cell kinetic measurements in human tumors. Pathol.

Annu. 16: 53-81.

Mielke, S., Sparreboom, A., Mross, K. (2006) Peripheral neuropathy: A persisting

challenge in paclitaxel based regimes. Eur. J. Cancer 42(1): 24-30.

Miglietta, A., Roberta, C., Claudia, B., Gabriel, L., Gasco, M.R. (2002) Cellular uptake

and cytotoxicity of solid lipid nanospheres (SLN) incorporating doxorubicin or

paclitaxel. Int. J. Pharm. 210: 61-67.

Mishra, D., Garg, M., Dubey, V., Jain, S., Jain, N.K. (2007) Elastic liposomes mediated

transdermal delivery of an anti- hypertensive agent: propranolol hydrochloride. J.

Pharm. Sci. 96: 145-155.

Mishra, D., Mishra, P., Dubey, V., Dabadghao, S., Jain, N.K. (2007) Evaluation of uptake

and generation of immune response by murine dendritic cells pulsed with

hepatitis B surface antigen-loaded elastic liposomes. J. Vaccine 25: 6939-6944.

References

-292-

Mo, Y., Lim, L.-Y. (2005) Preparation and in vitro anticancer activity of wheat germ

agglutinin (WGA)-conjugated PLGA nanoparticles loaded with paclitaxel and

isopropyl myristate. J. Control. Release 107: 30-42.

Moore, D.J., Powis, G., Richardson, R.L., Pittelkow, M.R. (1985) Topical chemotherapy

of intradermal Walker 256 carcinosarcoma with diaziquone and doxorubicin in

the rat. Cancer Res. 45: 5466-5472.

Mu, L., Feng S.S. (2003) A novel controlled release formulation for the anticancer drug

Paclitaxel: PLGA nanoparticles containing Vitamin E TPGS. J. Control. Release

86: 33-48.

Mulik, R.S., Kulkarni, V.I., Murthy, R.S.R. (2009) chitosan based thermosensitive

hydrogel containing liposomes for sustained delivery of cytarabine. Drug. Dev.

Ind. Pharm. 35(1): 49-56.

Müller, R.H., Mäder, K., Gohla, S. (2000) Solid lipid nanoparticles (SLN) for controlled

drug delivery-a review of the state of the art. Eur. J. Pharm. Biopharm. 50: 161-

178.

Mura, A., Maestrelli, F., Gonzlez-Rodrguez, M.L., Michelacci, I., Ghelardini, C.,

Rabasco, A.M. (2007) Development, characterization and in vivo evaluation of

benzocaine-loaded liposomes. Eur. J. Pharm. Biopharm. 67(1): 86-95.

Nagase, Y., Hirata, M., Arima, H., Tajiri, S., Nishimoto, Y., Hiryama, R., Uekama, K.,

(2002) Protective effect of sulfobutylether β-cyclodextrins on DY-9760e-induced

hemolysis in vitro. J. Pharm. Sci. 91(11): 2382-2389.

Naha, P., Bhattacharya, K., Tenuta, T., Dawson, K., Lynch, I., Gracia, A., Lyng, F.,

Byrne, H. (2010) Intracellular localisation, geno- and cytotoxic response of poly

N-isopropylacrylamide (PNIPAM) nanoparticles to human keratinocyte (HaCaT)

and colon cells (SW 480). Toxi. Lett. 198(2): 134-143.

Naik, S., Patel, D., Chuttani, K., Mishra, A.K., Misra, A. (2012) In vitro mechanistic

study of cell death and in vivo performance evaluation of RGD grafted

References

-293-

PEGgylated docetaxel liposomes in breast cancer. Nanomed.: Nanotechnol. 8(6):

951-962.

Nair, L.S., Starness, T., Ko, J.W.R, Laurencin, C.T. (2007) Development of injectable

thermogelling chitosan-inorganic phosphate solutions for biomedical applications.

Biomacromolecules 8: 3779-3785.

Nair, V.B., Panchagnula, R. (2003) Effect of iontophoresis and fatty acids on permeation

of arginine vasopressin through rat skin. Pharmacol. Res. 47(6): 563-569.

Nassier, O. A. (2010) Protein undernutrition in tumor-bearing mice, response and toxicity

to paclitaxel. Int. J. Pharm. 6(3): 296-300.

Nava, G., Pinon, E., Mendoza, L., Mendoza, N., Quintanar, D., Ganem, A. (2011)

Formulation and in vitro, ex vivo and in vivo evaluation of elastic liposomes for

transdermal delivery of Ketorolac Tromethamine. Pharmaceutics 3: 954-970.

Nepal, O., Rao, J.P. (2011) Haemolytic effects of hypo-osmotic salt solutions on human

erythrocytes. Kathmandu. Univ. Med. J. 34(2): 35-39.

Nishiyama, N., Okazaki, S., Cabral, H., Miyamoto, M., Kato, Y., Sugiyama, Y. (2003)

Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in

mice. Cancer Res. 63: 8977-8983.

Nornoo, A.O., Osborne, D.W., Chow, S.L. (2008). Cremophor-free intravenous

microemulsions for paclitaxel I: formulation, cytotoxicity and hemolysis. Int. J.

Pharm. 349: 108-116.

Nsereko, S., Amiji, M. (2002) Localized delivery of paclitaxel in solid tumors from

biodegradable chitin microparticle formulations. Biomaterials 23: 2723-2731.

Obara, K., Ishihara, M., Ozeki, Y., Ishizuka, T., Hayashi, T., Nakamura, S., Saito, Y.,

Yura, H., Matsui, T., Hattori, H., Takase, B., Ishihara, M., Kikuchi, M

Maehara, T. (2005) Controlled release of paclitaxel from photocrosslinked

chitosan hydrogels and its subsequent effect on subcutaneous tumor growth in

mice. J. Control. Release 110: 79-89.

References

-294-

Okano, T., Bae, Y.H., Jacobs, H., Kim, S.W. (1990) Thermally on-off switching

polymers for drug permeation and release. J. Control. Release 11: 255-265.

Omelyanenko, V., Kopeckova, P., Gentry, C., Kopecek, J. (1998) Targetable HPMA

copolymer-adriamycin conjugates. Recognition, internalization and subcellular

fate. J. Control. Release 53: 25-37.

Ooya, T., Lee, J., Park, K. (2003) Effects of ethylene glycol-based graft, star-shaped, and

dendritic polymers on solubilization and controlled release of paclitaxel. J.

Control. Release 93: 121-127.

Ortiz, R., Jessie, L.S., Lu, A.Z., Gan, Y., Wientjes, M. (2007) Biodegradable intra

prostatic Doxorubicin implants. AAPS J. 9(2): E241-E250.

Pakunlu, R.I., Wang, Y., Saad, M., Khandare, J.J., Starovoytov, V., Minko, T. (2006) In

vitro and in vivo intracellular liposomal delivery of antisense oligonucleotides and

anticancer drug. J. Control. Release 114: 153-162.

Panayiotis, P., Constantinides, K.J., Tustian, A.K., Schneider, B., Lalji, S., Ma, W.,

Wentzel, B., Kessler, D., Worah, D., Quay, S.C. (2002) Formulation development

and antitumor activity of a filter sterilizable emulsion of paclitaxel. Pharm. Res.

17(2): 175-182.

Panchagnula, R. (1998) Pharmaceutical aspects of paclitaxel Int. J. Pharm. 172: 1-15.

Panchagnula, R., Desu, H., Jain, A., Khandavilli, S. (2004) Effect of lipid bilayer

alteration on transdermal delivery of a high molecular weight and lipophilic drug:

Studies with paclitaxel. J. Pharm. Sci. 93(9): 2177-2183.

Panchagnula, R., Desu, H., Jain, A., Khandavilli, S. (2005) Feasibility studies of dermal

delivery of paclitaxel with binary combinations of ethanol and isopropyl

myristate: role of solubility, partitioning and lipid bilayer perturbation. IL

Farmaco 60: 894-899.

Panchagnula, R., Salve, P.S., Thomas, N.S., Jain, A.K., Ramarao, P. (2001) Transdermal

delivery of naloxone: effect of water, propylene glycol, ethanol and their binary

combinations on permeation through rat skin. Int. J. Pharm. 219 (1-2): 95-105.

References

-295-

Panchagnula, R., Dhanikula, R.S., Dhanikula, A.B. (2006) An ex vivo characterization of

Paclitaxel loaded chitosan films after implantation in mice. Curr. Drug

Deliv. 3(3): 287-297.

Paolino, D., Celia, C., Trapasso, E., Cilurzo, F., Fresta, M. (2012) Paclitaxel-loaded

ethosomes: Potential treatment of squamous cell carcinoma, a malignant

transformation of actinic keratoses. Eur. J. Pharm. Biopharm. 81(1): 102-112.

Park, J.H., Chi, S.C., Lee, W.S., Lee, W.M., Koo, Y.B., Yong, C.S., Choi, H.G., Woo,

J.S. (2009) Toxicity studies of Cremophor-free paclitaxel solid dispersion

formulated by a supercritical anti solvent process. Arch. Pharm. Res. 32(1): 139-

148.

Park, J.H., Chi, S.C., Woo, J.S. (2008) Preparation and evaluation of paclitaxel solid

dispersion by supercritical anti-solvent process. J. Korean Pharm. Sci. 38(4):

241-247.

Park, Y.D., Tirelli, N., Hubbell, J.A. (2003) Photopolymerized hyaluronic acid-based

hydrogels and interpenetrating networks. Biomaterials 24: 893-900.

Paul, A., Cevc, G., Bachhawat B.K. (1995a) Transdermal immunization with large

proteins by means of ultra deformable drug carriers. Eur. J. Immunol. 25: 3521-

3524.

Paul, A., Cevc, G., Bachhawat, B. K. (1998) Transdermal immunisation with an integral

membrane component, gap junction protein, by means of ultradeformable drug

carriers, transfersomes. Vaccine 16(2-3): 188-195.

Perdue, J.D., Seaton, P.J., Tyrell, J.A., Devido, D.R. (2006) The removal of Cremophor®

EL from paclitaxel for quantitative analysis by HPLC-UV. J. Pharm. Biomed.

Anal. 41:117-123.

Perez, E.A. (1998) Paclitaxel in breast cancer. The Oncologist 3: 375-389.

Peter, S.J., Miller, S.T., Zhu, G.M., Yasko, A.W., Mikos, A.G. (1998) In vivo degradation

of a poly (propylene fumarate)/tricalcium phosphate injectable composite

scaffold. J. Biomed. Mater. Res. 41: 1-7.

References

-296-

Peters, M., Byod, E.M. (1967) The influence of a cachexigenic diet on caffeine toxicity.

Toxicology & Applied Pharmacology. 11(1):121-127.

Pinto Reis, C., Neufeld, R.J., Ribeiro, A.J., Veiga, F.I. (2006) Nanoencapsulation:

Methods for preparation of drug-loaded polymeric nanoparticles. Nanomedicine

2: 8-21.

Planas, M.E., Gonzalez, P., Rodriguez, L., Sanchez, S., Cevc, G. (1992) Noninvasive

percutaneous induction of topical analgesic by a new type of drug carrier and

prolongation of local pain insensitivity by anesthetic liposomes. Anesth. Analg.

75: 615-621.

Puri, R.,Jain, S. (2012) Ethogel topical formulation for increasing the local

bioavailability of 5-Flurouracil: A Mechanistic study. Anti cancer drugs

Qiu, Y., Gao, Y., Hu, K., Li, F. (2008) Enhancement of skin permeation of docetaxel: A

novel approach combining microneedle and elastic liposomes. J. Control. Release

129(2):144-150.

Rand, R.P., Parsegian, V.A. (1990) Hydration forces between phospholipid bilayers.

Biochim. Biophys. Acta. 988: 351-376.

Rane, S., Prabhakar, B. (2009) Influence of liposome composition on paclitaxel

entrapment and pH sensitivity of liposomes. Int. J. Pharmtech. Res. 1(3): 914-

917.

Ravichandiran, V., Masilamani, K., Senthilnathan, B. (2011) Liposome-A versatile drug

delivery system. Der Pharmacia Sinica 2(1): 19-30.

Reed, K.W., Yalkowsky, S.H. (1985) Lysis of human red blood cells in the presence of

various cosolvents. J. Parenter. Sci. Tech. 39: 64-69.

Ritschel, W.A., Panchagnula, R., Stemmer, K. and Asharaf, M. (1991) Development of

an intracutaneous depot for drugs. Skin Pharmacol. 4: 235-245.

Rodrigues, D.G., Maria, D.A., Fernandes, D.C., Valduga, C.J., Couto, R.D., Ibanez, O.C.

(2005) Improvement of paclitaxel therapeutic index by derivatization and

References

-297-

association to a cholesterol-rich microemulsion: in vitro and in vivo studies.

Cancer Chemother. Pharmacol. 55: 565-576.

Rotunda, A.M., Suzuki, H., Moy, R.L., Kolodney, M.S. (2004) Detergent effects of

sodium deoxycholate is a major feature of an injectable phosphatidylcholine

formulation used for localized fat dissolution. Dermatol. Surg. 30: 1001-1008.

Ruel-Gariepy, E., Chenite, A., Chaput, C., Guirguis. S., Leroux, J.C. (2000)

Characterization of thermosensitive chitosan gels for the sustained delivery of

drugs. Int. J. Pharm. 203: 89-98.

Ruel-Gariepy, E., Leclair, G., Hildgen, P., Gupta, A., Leroux, J.C. (2002)

Thermosensitive chitosan based hydrogel containing liposomes for the delivery of

hydrophillic molecules. J. Control. Release 82: 373-383.

Ruel-Gariepy, E., Matthew Shive, E., Bichara, A., Berrada, M., Garrec, D.L., Chenite,

A., Leroux, J.C. (2004) Thermosensitive chitosan-based hydrogel for the local

delivery of paclitaxel. Eur. J. Pharm. Biopharm. 57: 53-63.

Saad, S. Y., Ali, M. (1999) Effect of taxol on the expression of transforming growth

factor beta-1 in Ehrlich ascites carcinoma cells. Saudi Pharm. J. 7(4): 201-204.

Sahoo, K., Labhasetwar, V. (2003) Nanotech approaches to drug delivery and imaging.

Drug Discov. Today 8: 1112-1120.

Sapra, B., Jain, S., Tiwary, A.K. (2008) Transdermal delivery of carvedilol containing

glycyrrhizin and chitosan as permeation enhancers: Biochemical, biophysical,

microscopic and pharmacodynamic evaluation. Drug Delivery 15: 443-454.

Saville, M.W., Lietzau, J., Pluda, J.M., Wilson, W.H., Humphrey, R.W., Feigel, E.,

Steinberg, S.M., Broder, S. (1995) Treatment of HIV-associated Kaposi's sarcoma

with paclitaxel. Lancet 346 (8966): 26-28.

Schatzlein, A., Cevc, G. (1995) Skin penetration by phospholipid vesicles, transfersomes,

as visualized by means of confocal laser scanning microscopy, in: G. Cevc, F.

Paltauf (Eds.), Phospholipids: Characterization, metabolism and novel biological

applications, AOCS Press, Champaign. IL. 191-209.

References

-298-

Schimtt, S.M., Strieth, S., Krasnici, S., Sauer, B., Schulze, B., Tefil, M., Michaelis, U,

Naujoks, K., Dellian, M. (2003) Neovascular targeting therapy: paclitaxel

encapsulated in cationic liposomes improves antitumoral efficacy. Clin. Cancer.

Res. 2003 9(6):2335-2341.

Scong, H., Jang, M., Wientjus, G., Jessie, L. (2001) Determinants of paclitaxel uptake,

accumulation and retention in solid tumors. Invest. New Drugs 19: 113-123.

Scott, C.J., Marouf, W.M, Quinn, D. J., Buick, R.J., Orr, S.J., Donnelly, R.F., McCarron,

P.A. (2008). Immunological targeting of the endocytotic siglec-7 receptor using

peripheralnattachment of siglec-7 antibodies to poly(Lactide-co-Glycolide)

nanoparticles. Pharm. Res. 135-146.

Selvam, S., Mishra, A.K. (2008) Disaggregation of amphotericin B by sodium

deoxycholate micellar aggregates. J. Photochem. Photobio. 93: 66-70.

Serpe, L., Catalano, M.G., Cavalli, R., Ugazio, E., Bosco, O., Canaparo, R., Muntoni, E.,

Frairia, R., Gasco, M.R., Zara, G.P. (2004) Cytotoxicity of anticancer drugs

incorporated in solid lipid nanoparticles on HT-29 colorectal cancer cell line. Eur.

J. Pharm. Biopharm. 58: 673-680.

Shackney, S.E., McCormack, G.W., Cuchural Jr, G.J. (1978) Growth rate patterns of

solid tumors and their relation to responsiveness to therapy: an analytical review.

Ann. Intern. Med. 89: 107-121.

Shakeel, F., Ramadan, W. (2010) Transdermal delivery of anticancer drug caffeine from

water-in-oil nanoemulsions. Colloids and Surfaces B: Biointerfaces. 75: 356-

362.

Shao, Z., Mitra, A.K. (1992) Nasal membrane and intercellular protein and enzyme

release by bile salts and bile-fatty acid mixed micelle: correlation with facilitated

drug transport. Pharm. Res. 9: 1184-1189.

Shapira, A., Livney, Y.D., Broxterman, H.J., Assaraf, Y.G. (2011) Nanomedicine for

targeted cancer therapy: Towards the overcoming of drug resistsnce. Drug Resist

Updat. 14(3): 150-163.

References

-299-

Sharma, A., Mayhew, E., Straubinger, R.M. (1993) Anti-tumor effect of taxol-containing

liposomes in a taxol-resistant murine tumor model. Cancer Res. 53: 5877-5881.

Sheihet, L., Garbuzenko, O.B., Bushman, J., Gounder, M.K., Minko, T., Kohn, J. (2012)

Paclitaxel in tyrosine-derived nanospheres as a potential anti-cancer agent: In vivo

evaluation of toxicity and efficacy in comparison with paclitaxel in Cremophor.

Eur. J. Pharm. Sci. 45: 320-329.

Shenoy, D.B., Amiji, M.M. (2005) Poly(ethylene oxide)-modified poly(ethylene oxide-

caprolactone) nanoparticles for targeted delivery of tamoxifen in breast cancer.

Int. J. Pharm. 293: 261-270.

Shikani, A.H., Domb, A.J. (2000) Polymer chemotherapy for head and neck cancer.

Laryngoscope 110: 907-917.

Shikanov, A., Shikanov, S., Vaisman, B., Golenserc, J., Domb, A.J. (2008) Paclitaxel

tumor biodistribution and efficacy after intratumoral injection of a biodegradable

extended release implant. Int. J. Pharm. 358: 114-120.

Shim, W.S., Kim, J.H., Kim, K., Kim, Y.S., Park, R.W., Kim, I.S., Kwon, C., Lee, D.S.

(2007) pH- and temperature-sensitive, injectable, biodegradable block copolymer

hydrogels as carriers for paclitaxel. Int. J. Pharm. 331: 11-18.

Shimomura, T., Fujiwara, H., Ikawa, S., Kigawa, J., Terakawa, N. (1998) Effect of taxol

on blood cells. Lancet. 352: 541-542.

Singh, H., Utreja, P., Tiwary, A.K., Jain, S. (2009) Elastic liposomal formulation for

sustained delivery of colchicine: In vitro characterization and in vivo evaluation of

anti-gout activity. AAPS J. 11(1): 54-64.

Singhai, A.K., Jain, S., Jain, N.K. (1997) Evaluation of an aqueous injection of

ketoprofen. Pharmazie 52: 2149-2151.

Singla, A.K., Garg, A., Agarwal, D. (2002) Paclitaxel and its formulations. Int. J.

Pharm. 235: 179-192.

References

-300-

Soga, O., Nostrum, C.F., Rijcken, C.J., Schiffelers, R.M., Strom, G., Hennink, W.E.

(2005) Thermo sensitive and biodegradable polymeric micelles for paclitaxel

delivery. J. Control. Release 103: 341-353.

Sonnichsen, D.S., Relling, M.V. (1994) Clinical pharmacokinetics of paclitaxel. Clin.

Pharmacokinetics 27: 256-269.

Soo, P.L., Cho, J., Grant, J., Ho, E., Miller, M.P., Allen, C. (2008) Drug release

mechanism of paclitaxel from a chitosan-lipid implant system: Effect of swelling,

degradation and morphology. Eur. J. Pharm. Biopharm. 69: 149-157.

Souto, E.B., Müller, R.H (2009) Lipid nanoparticles-Effect on bioavailability and

pharmacokinetics changes, M. Schäfer-Korting, Editor, Handbook of

Experimental Pharmacology - Novel Drug Delivery Approaches, Vol.

197 Springer Verlag, Heidelberg, Berlin, Germany (2009), pp. 115-142 Chapter 4.

Souza, J. G., Gelfuso, G. M., Simao, P. S., Borges, A. C., Lopez, R. F. (2011)

Iontophoretic transport of zinc phthalocyanine tetrasulfonic acid as a tool to

improve drug topical delivery. Anticancer Drugs 22(8): 783-793.

Spratlin, J., Sawyer, M.B. (2007) Pharmacogenetics of paclitaxel metabolism. Crit. Rev.

Oncology. Hemat. 61: 222-229.

Sqadari, C.,Toschi, E., Palladino, C., Barrilari, G., Carlei, D., Cereseto, A., Ciccolella, C.,

Yarchoan, R., Monini, P., Stuzul, M. (2000) Mechanism of paclitaxel activity in

Kapsoi’s sarcoma. J. Immunol. 165(1):509-517.

Stewart, D.J. (2007) Mechanisms of resistance to cisplatin and carboplatin. Crit. Rev.

Oncol. Hematol. 63: 12-31.

Su, M., Zhao, M., Luo, Y., Lin, X., Xu, L., He, H., Xu, H., Tang, X. (2011) Evaluation of

the efficacy, toxicity and safety of vinorelbine incorporated in a lipid emulsion.

Int. J. Pharm. 411 (1-2): 188-196.

Sun, B., Ranganathan, B., Feng, S.S. (2008) Multifunctional poly(D,L- lactide-co-

glycolide)/montmorillonite PLGA/MMT nanoparticles decorated by Trastuzumab

for targeted chemotherapy of breast cancer. Biomaterials 29: 475-486.

References

-301-

Suppasansatorn, P., Nimmanni, U., Conwa, B.R., Lingran, D., Wan, Y (2007)

Microemulsion as topical delivery vehicles for the anti-melanoma prodrug,

temozolomide hexyl ester (TMZA-HE). J. Pharm. Pharmacol. 59(6): 787-794.

Szebeni, J., Muggia, F.M., Alving, C.R. (1998) Complement activation by cremophor EL

as a possible contributor to hypersensitivity to Paclitaxel an in vitro study. J. Nat.

Cancer. Inst. 90: 300-306.

Szoka, F., Papahadjopoulos, D. (1980) Comparative properties and methods of

preparation of lipid vesicles (liposomes). Annu.Rev.Biophys.Bioeng. 9: 467-508.

Szoka, F., Papahadjopoulos, D. (1980) Comparative properties and methods of

preparation of lipid vesicles (liposomes). Ann. Rev. Biophys. Bioeng. 9: 467-508.

Tahar, Y., Ishii, Y., (2001) Apatite cement containing cis-diaminedichloro platinum

implanted in rabbit femur for sustained release of anticancer drug and bone

formation. J. Orthop. Sci. 6(6): 556-565.

Tamm, L.K., Tatulian, S.A. (1997) Infrared spectroscopy of proteins and peptides in lipid

bilayers. Q. Rev. Biophys. 30(4): 365-429.

Tannock, I.F. (2001) Tumor physiology and drug resistance. Cancer Meta. Rev.20: 123-

132.

Teskac, K., Kristi, J. (2010) The evidence for solid lipid nanoparticles mediated cell

uptake of Resveratrol. Int. J. Pharm. 390(1): 61-69.

Thein-Han, W.W., Steven, W.F. (2004) Transdermal delivery controlled by chitosan

membrane. Drug Dev. Ind. Pharm. 30(4): 397-404.

Torchilin, V.P. (2005) Fluorescence microscopy to follow the targeting of liposomes and

micelles to cell and their intracellular fate. Adv. Drug Deliv. Rev. 57: 95-109.

Trotta, M., Peira, E., Carlotti, M.E., Gallarate, M. (2002) Elastic liposomes for skin

delivery of dipotassium glycyrrhizinate. Int. J. Pharm. 241: 319-327.

References

-302-

Tsallas, A., Jackson, J., Burt, H. (2011) The uptake of paclitaxel and docetaxel into ex

vivo porcine bladder tissue from polymeric micelle formulations. Cancer

Chemother. Pharmacol. 68(2): 431-444.

Urbinati, G., Marsaud, V., Plassat, V., Fattal, E., Lesieur, S., Michel, J. (2010) Renoir

liposomes loaded with histone deacetylase inhibitors for breast cancer therapy.

Int. J. Pharm. 397(1-2): 184-193.

Utreja, P., Jain, S., Tiwary, A.K. (2011) Localized delivery of paclitaxel using elastic

liposomes: Formulation development and evaluation. Drug Deliv. 18(5): 367-376.

Vanden Bergh B.A., Bouwstra J.A., Junginger, H.E., Wertz, P.W. (1999) Elasticity of

vesicles affects hairless mouse skin structure and permeability. J. Control.

Release 62: 367-379.

Vanden Bergh, B.A., Salomons-de-Vries, I., Bouwstra, J.A. (1998) Interaction between

liposomes and human stratum corneum studied by freeze-substitution electron

microscopy. Int. J. Pharm. 167: 57-67.

Vanden Bergh, B.A., Wertz, P.W., Junginger, H.E., Bouwstra, J.A. (2001) Elasticity of

vesicles assessed by electron spin resonance, electron microscopy and extrusion

measurements. Int. J. Pharm. 217: 13-24.

Van-Kuijk, M.E.M.J., Junginger, H.E., Bouwstra, J.A. (1998) Interaction between

liposomes and human skin in vitro, a confocal laser scanning microscopy study.

Biochem. Biophy. Acta. 1022:171-180.

Varma, M.V.S., Panchagnula, R. (2005) Enhanced oral paclitaxel absorption with

vitamin E-TPGS: Effect on solubility and permeability in vitro, in situ and in vivo.

Eur. J. Pharm. Sci. 25: 445-453.

Vasir, K., Reddy, M.K., Labhasetwar, V. (2005) Nanosystems in drug targeting:

opportunities and challenges. Curr. Nanosci. 1: 47-64.

Verma, D.D., Verma, S., Blume, G., Fahr, A. (2003) Particle size of liposomes influences

dermal delivery of substances into skin. Int. J. Pharm. 258: 141-151.

References

-303-

Vodovozova, E.L., Kuznetsova, N.R., Gaenko, G.P., Molotkovsky, J.G. (2007)

Liposomal formulation of a methotrexate diglyceride conjugate: Activity toward a

culture of methotrexate-resistant leukemia cells. Russian J. Bioorg. Chem. 33(4):

436-438.

Wang, C., Wang, Y.J., Fan, M., Luo, F., Qian, Z. (2011a) Characterization,

pharmacokinetic and disposition of novel nanoscale preparations of paclitaxel.

Int. J. Pharm. 414(1-2): 251-259.

Wang, S., Shanga, D., Lia, X., Jianga, T. (2009) Preparations and properties of

hydroxycamptothecin emulsion and its tissue distribution in mice. Asian J.

Pharm. Sci. 4(5): 299-307.

Wang, Y., Wu, K.C., Zhao, B.X., Zhao, X., Wang, X., Chen, S., Nie, S.F., Pan, W.F.,

Zhang, X., Zhang, Q. (2011b) Novel paclitaxel microemulsion containing a

reduced amount of Cremophor EL: Pharmacokinetics, biodistribution, and in vivo

antitumor efficacy and safety. J. Biomed. Biotechnol. (doi:10.1155/2011/854872)

Wani, M.C., Tylor, H.L., Wall, M.E., Coggon, P., Mcphail, A.T. (1971) Plant antitumor

agents. VI. The isolation and structure of taxol, a novel antileukemic and

antitumor agent from texus brevifolia. J. Am. Chem. Soc. 93: 2325-2327.

Watkins, J. (1979) Anaphylactic reactions to i.v. substances. J. Anaesth. 51: 51-60.

Wei., Z., Hao, J., Yuan, S., Li, Y., Juan, W., Sha, X., Fang, X. (2009) Paclitaxel-loaded

pluronic p123/F127 mixed polymeric micelles: Formulation, optimization and in

vitro characterization. Int. J. Pharm. 276: 176-185.

Weiss, R.B., Donehower, R.C., Wiernik, P.H., Ohnuma, T., Gralla, R.L., Trump, D.,

Baker, R., Vanecho, D.A., Vonhoff, D.D., Leyland-Jones, B. (1990)

Hypersensitivity reactions from taxol. J. Clin. Oncol. 8: 1263-1268.

Weitong, S., Zhang, N., Li, A., Zou, W., Xu, W. (2008) Preparation and evaluation of

N3-O toluyl-fluorouracil-loaded liposomes. Int. J. Pharm. 353: 243-250.

Wissing, S.A., Kayser, O., Muller, R.H. (2004) Solid lipid nanoparticles for parenteral

drug delivery. Adv. Drug Deliv. Rev. 56: 1257-1272.

References

-304-

Wolinsky, J.B., Colson, Y.L., Grinstaff, M.W (2012) Local drug delivery strategies for

cancer treatment: Gels, nanoparticles, polymeric films, rods, and wafers. J.

Control. Release 159 (1): 14-16.

Wu, J., Su, Z.G., Ma, G.H. (2006) A thermo- and pH sensitive hydrogel composed of

quaternized chitosan/glycerophosphate. Int. J. Pharm. 315: 1-11.

Xiao, W., Luo, J Jain, T., Riggs, J.W., Teseng, H.P., Henderson, P.T., Cherry, S.R.,

Rowland, D., Lam, K.S. (2012) Biodistribution and pharmacokinetics of

telodendrimer micellar paclitaxel nanoformulation in a mouse xenografts model

of ovarian cancer. Int. J. Nano medicine 7:1585-1597.

Xua, Z., Gu, W., Huang, J., Sui, H., Zhou, Z. Yang,Y., Yan, Z., Li, Y. (2005) In vitro and

in vivo evaluation of actively targetable nanoparticles for paclitaxel delivery. Int.

J. Pharm. 288: 361-368.

Yanasarn, N., Sloat, B.R., Cui, Z. (2009) Nanoparticles engineered from lecithin-in-water

emulsions as a potential delivery system for docetaxel. Int. J. Pharm. 379: 174-

180.

Yang, T., Choi, M.K., Cuia, F.D., Kim, J.S., Chung, S.J., Shim, C.K., Kim, D.D.

(2007b) Preparation and evaluation of paclitaxel-loaded PEGylated

immunoliposome. J. Control. Release 120: 169-177.

Yang, T., Cui, F.D., Choi, M.K., Cho, J.W., Chung, S.J., Shim, C.K., Kim, D.D. (2007)

Enhanced solubility and stability of PEGylated liposomal paclitaxel: In vitro and

in vivo evaluation. Int. J. Pharm. 338: 317-326.

Yang, T., Cui, F.D., Choi, M.K., Lin, H., Chung, S.-J., Shim, C.-K., Kim, D.-D. (2007a)

Liposome formulation of paclitaxel with enhanced solubility and stability. Drug

Deliv. 14: 301-308.

Yann, H., Miao, J., Du, Y.Z., You, J., Hu, F.Q., Zeng, S. (2008) Cellular uptake of solid

lipid nanoparticles and cytotoxicity of encapsulated paclitaxel in A549 cancer

cells. Int. J. Pharm. 348: 137-145.

References

-305-

Yoshizawa, Y., Kono, Y., Ogawara, K.I., Kimura, T., Higaki, K. (2011) PEG

liposomalization of paclitaxel improved its in vivo disposition and anti-tumor

efficacy. Int. J. Pharm. 412: 132-141.

Zaafarany, G.M., Awad, G.A., Holayel, S.M., Mortada, N.D. (2010) Role of edge

activators and surface charge in developing ultradeformable vesicles with

enhanced skin delivery. Int. J. Pharm. 397(1-2): 164-172.

Zahr, A.S., Pishko, M.V. (2007) Encapsulation of paclitaxel in macromolecular

nanoshells. Biomacromolecules 8: 2004-2010.

Zeljka Pavelic, Z., Basnet, N.S., Schubert, R. (2001) Liposomal gels for vaginal drug

delivery. Int. J. Pharm. 219(1-2): 139-149.

Zellmer, S., Pfeil, W., Lasch, J. (1995) Interaction of phosphatidyl choline liposomes

with the human stratum corneum. Biochim. Biophy. Acta 1237: 176-182.

Zhang, A., J., Xuan, T., Parmar, M., Ma, L., Ugwu, S., Ali, S., Ahmad, I. (2004)

Development and characterization of a novel liposome-based formulation of SN-

38. Int. J. Pharm. 270: 93-107.

Zhang, H., Wang, Z.Y., Gong, W., Li, Z.P., Mei , X.G., Lv, W.L. (2011) Development

and characteristics of temperature-sensitive liposomes for vinorelbine bitartrate.

Int. J. Pharm. 414(1-2): 56-62.

Zhang, J. Q., Zhang, Z.R., Yang, H., Tan, Q.Y., Qin, S.R., Qiu, X.L. (2005) Lyophilized

paclitaxel magnetoliposomes as a potential drug delivery system for breast

carcinoma via parenteral administration: in vitro and in vivo studies. Pharm. Res.

22(4): 573-583.

Zhang, W., Junguo, H., Yuan, S., Li, Y., Juan, W., Sha, X., Fang, X. (2009) Paclitaxel-

loaded pluronic P123/F127 mixed polymeric micelles: formulation, optimization

and in vitro characterization. Int. J. Pharm. 376: 176-185.

Zhang, Z., Feng S.S. (2007) The drug encapsulation efficiency, in vitro drug release,

cellular uptake and cytotoxicity of paclitaxel-loaded poly(lactide)-tocopheryl

polyethylene glycol succinate nanoparticles. Biomaterials 27: 4025-4033.

References

-306-

Zhao, Q.H., Zhang, Y., Liu, Y., Li, H., Shen, W.Y., Yang, W.J., Wen, L.P. (2010)

Anticancer effect of realgar nanoparticles on mouse melanoma skin cancer in vivo

via transdermal drug delivery. Med. Oncol. 27 (2): 203-212.

Zhenghong, X., Lingli, C., Wangwen, G., Gao, U.,. Liping, L., Zhang, Z., Li, Y. (2009)

The performance of docetaxel-loaded solid lipid nanoparticles targeted to

hepatocellular carcinoma. Biomaterials 30: 226-232.

Zhou, H.Y., Chen, X.G., Kong, M., Liu, L.C. (2009) Preparation of chitosan-based

thermosensitive hydrogel for drug delivery. J. Appl. Polym. Sci. 112: 1509-1515.

Websites:

www.rnspeak.com/pathophysiology/cancer

Wikipedia (http://en.wikipedia.org/wiki/Paclitaxel) accessed on May 2012.