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2/23/17 1 CLINICAL ROLE OF PHARMACIST TO IMPROVE MENTAL HEALTH OUTCOMES AMONG VETERANS JUNE A. GRIFFITH, Pharm D, CGP, BCPP Tuscaloosa Veterans Affair Medical Center PGY 2 Residency Director Psychiatric pharmacy practice February 24, 2017 Disclosure Statement I do not have a vested interest or affiliation with any corporate organization offering financial support or grant money for this continuing education program or any affiliation with an organization whose philosophy could potentially bias any presentation. OR I do not have a vested interest in or affiliation with any corporate organization offering financial support or grant money for this continuing education program, or any affiliation with an organization whose philosophy could potentially bias my presentation. OJECTIVES Upon completion of this CE activity, pharmacists, nurses, and other healthcare professionals should be able to : Understand the various types of mental illness that might go untreated: Abuse of drugs and Alcohol to treat mental health problems: Need of pharmacists to educate veterans about the correct TX of mental health conditions: Types of OTC treatments for mental health Interactions with OTC and conventional medications. Ways to reduce the stigma of mental health disorders Identify the various types of mental health disorders and know when to refer for treatment. OBJECTIVES Upon completion of this CE activity, Technicians and students should be able to: Understand the various types of mental illness that might go untreated; Abuse of drugs and Alcohol to treat mental health problems; Need of pharmacists, technicians and students to educate each other and family members about the correct TX of mental health conditions; Types of OTC treatment for mental health; Interactions between OTC agents and conventional medications, Ways to reduce the stigma of mental health disorders Identify the various types of mental health disorders and know when to refer for treatment.

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Page 1: CHE Dr. Griffith CLINICAL ROLE OF PHARMACIST TO IMPROVE …pharmacy.famu.edu/wp-content/uploads/2017/02/CHE-Dr... · 2017-02-23 · 2/23/17 1 CLINICAL ROLE OF PHARMACIST TO IMPROVE

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CLINICALROLEOFPHARMACISTTOIMPROVEMENTALHEALTHOUTCOMESAMONGVETERANS

JUNEA.GRIFFITH,PharmD,CGP,BCPPTuscaloosaVeteransAffairMedicalCenter

PGY2ResidencyDirectorPsychiatricpharmacypracticeFebruary24,2017

DisclosureStatement

Idonothaveavestedinterestoraffiliationwithanycorporateorganizationofferingfinancialsupportorgrantmoneyforthiscontinuingeducationprogramoranyaffiliationwithanorganizationwhosephilosophycouldpotentiallybiasanypresentation.

ORIdonothaveavestedinterestinoraffiliationwithanycorporateorganizationofferingfinancialsupportorgrantmoneyforthiscontinuingeducationprogram,oranyaffiliationwithanorganizationwhosephilosophycouldpotentiallybiasmypresentation.

OJECTIVES

• UponcompletionofthisCEactivity,pharmacists,nurses,andotherhealthcareprofessionalsshouldbeableto:• Understandthevarioustypesofmentalillnessthatmightgountreated:• AbuseofdrugsandAlcoholtotreatmentalhealthproblems:• NeedofpharmaciststoeducateveteransaboutthecorrectTXofmentalhealthconditions:• TypesofOTCtreatmentsformentalhealth• InteractionswithOTCandconventionalmedications.• Waystoreducethestigmaofmentalhealthdisorders• Identifythevarioustypesofmentalhealthdisordersandknowwhentoreferfortreatment.

OBJECTIVES

• UponcompletionofthisCEactivity,Techniciansandstudentsshouldbeableto:• Understandthevarioustypesofmentalillnessthatmightgountreated;• AbuseofdrugsandAlcoholtotreatmentalhealthproblems;• Needofpharmacists,techniciansandstudentstoeducateeachotherandfamilymembersaboutthecorrectTXofmentalhealthconditions;• TypesofOTCtreatmentformentalhealth;• InteractionsbetweenOTCagentsandconventionalmedications,• Waystoreducethestigmaofmentalhealthdisorders• Identifythevarioustypesofmentalhealthdisordersandknowwhentoreferfortreatment.

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ANXIETYVSDEPRESSION

ANXIETY

SAD

PANIC

GAD

SEPARATION

OCD

PTSD

ANXIETYVSDEPRESSION

• TypesofAnxietydisorders:• SAD– socialanxietydisorder– fearofbeinginpublicplaceswiththepossibilityofbeingembarrassed• GAD– Generalizedanxietydisorder– excessiveanxietyorworryaboutalmosteverythingandconstantworrying• PD– panicdisordercharacterizedbyintensefearthatlastfor5– 10secondsandthensubsides.Notsurewhenitwilloccuragain.• OCD– obsessivecompulsivedisorderswhichischaracterizedbyfearandcontinuousritualstocalmfearsthatmainlyincreasesthefearmore.• Separationanxiety– afraidtobeseparatedfromloveones,orfamilymembersduetofearofsomethingbadhappeningtoloveones.• PTSD– removedfromanxietydisorderinDSMVcriteria,butisstillactuallyananxietytypeofdisorder.

ANXIETYVSDEPRESSION

• TreatmentforanxietyisusuallytheuseofSSRI– SelectiveSerotoninreceptoruptakeinhibitors.• Itinhibitsthereuptakeofserotoninforthereceptorstorepackageitanduseitagain.Insteadthereisaconstantsupplyofserotonininthereceptorsynapticcleft,leadingtoincreasebindingtotheserotoninreceptor.• AnothertypeoftreatmentistheSNRI– Serotoninnorepinephrinereceptoruptakeinhibitors-• Itallowsforserotoninandnorepinephrinetobeavailabletothereceptorsalotlongerandthereforeleadstoincreaseactions.• Thenorepinephrine– dopaminereceptorreuptakeinhibitors–Wellbutrinorbupropion- allowsfornorephinphrineanddopaminetobeavailablealotlongerinthereceptorsynapticcleft.

ANXIETYVSDEPRESSION

• THESAMEAGENTSUSEDTOTREATANXIETYISALSOUSEDTOTREATDEPRESSION.

• WHY?????

• DEPRESSIONischaracterizedbyhaving5ormoreofthefollowingsymptomseverydayforatleast2weeks– depressedmood,irritability,anxiety,tearfulnessandsomaticcomplaints.• AnacronymusedisSIGECAPS

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ANXIETYVSDEPRESSION

• S- sleepdisturbance(insomniaorhypersomnia)• I– Interest(lossof)• G- Guilt(excessive)• Energy(Changesin)• Concentration(impaired)• AppetiteChanges(increasedordecreased)• Psychomotoragitationorretardation• Suicidalideationsoractions• Somaticcomplaints– (GIdisturbances,headaches,musclepain)

CPNPPyschiatricPharmacotherapyreviewpg188 9

ANXIETYVSDEPRESSION

• Ifanxietygoesuntreatedforalongperiodoftime,dependingontheseverityitcanproducedepressionsymptomsnext.• Thatiswhyitisimportanttorecognizedandgettherapyassoonaspossible.• Pillsarenottheonlywaytotreatdepressionandanxiety.• Psychotherapy–• CBT– Cognitivebehaviortherapy– patientaretaughttorecognizedbadthoughtsandlearnhowtochangethoughtprocesses.• ECT– electroconductivetherapy– forseveredepression.

EVALUATIONCASESTUDY

• Awomanis24yearsoldfemale,complainsofchestpain,shortnessofbreathandimpendingdomewhileinacrowdedshoppingcenter,thishasoccurredonmorethanoneoccasionandaftertravellingtotheER.AttheERifwasdeterminedthattheywasnocardiacinvolvement.• 1)Whattypeofanxietydisorderisthiscondition?• a)SocialAnxiety• b)panicdisorder• c)generalizedanxietydisorder• d)separationanxiety

EVALUATIONCASESTUDY

• Aftermanymonthsofthisdisorderthepatienthasstopsocializingwithherfriends,andhasstopleavingthehouseeventobutgroceries.Whattypeofsymptomisthispatientexperiencing?• a)Guilt• b)lossofinterest• c)isolation• d)changesinenergy

• Howwouldthisconditionbetreatedwithwhatagent?• a)SSRIb)Busparc)lorazepamd)St.John’swort

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BIPOLARDISORDER DIAGNOSTICCRITERIA

HYPOMANIC HYPOMANICCRITERIA

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SPECTRUMOFMOODS DIAGNOSTICCRITERIA

BIPOLARDISORDER1OR11

• BIPOLARTERMSusedtobecalledmanicdepressivedisorders.

• Bipolar1– apersonwhohavehadatleastonemanicepisodeinhis/herlifetime.• Bipolar11– mainlycharacterizedbydepressiveepisodeandhypomanicepisode.• Manicischaracterizedbyperiodofloudexpansivemood,withrequirementoflittlesleepandthoughtsofonlyselfpleasurableactivities,thatusuallyrequireeitherhospitalizationorincarceration.• Hypomanicisusuallyperiodofhighexpansivemoodbutnotattheseverityofmanicandrequiringlessneedforsleep.Usuallylasting4-7days,beforecrashingintodepression.

BIPOLAR1OR11

• Mostpatientswithbipolartype11usuallygoestotheirdoctorwhentheyareinadepressiveepisode.• Wheninahypomanicepisode,theyfeelgood,extraenergyandabletodoalotoftasks,butmightnotfinishanyofthemcompletely.• Inthemanicphasic,havelotofracingthoughtsandwanttodoalotofdifferentthings,butmightnevercompleteanything.• Inmanicphasemoreinterestedwiththepleasurableactivities,thanworkorproduction.• Whichusuallyleadtooverspending,extramartialaffairswithmanypartners,gamblinganddoingdrugsandoftenquestionableactivitiesthatmayendupinjailorhospital.• Treatmentisoftencomplex,andusuallyendsupwithalotofnon-compliance.

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TREATMENTOFBIPOLAR1AND11

• DRUGOFCHOICEISLITHIUM.• MOODSTABILIZER– DEPAKOTE,CARBAMAZEPINE,LAMICTAL,• SSRI,SNRI– BUTMUSTBEACCOMPANIEDBYAMOODSTABILIZERONBOARDOTHERWISEITMAYCAUSESWITCHINGTOMANIA• BUPROPIONISTHEONLYANTIDEPRESSANTTHATISLESSLIKELYTOCAUSESWITCHINGTOMANIA.• WHYDOESANTI-EPILEPTICAGENTHELPWITHMOODSTABILIZATION• ITACTUALLYSLOWSDONETHEFASTRACINGTHOUGHTSANDGIVETHEBRAINTIMETOMAKERATIONALDECISIONINSTEADOFBEINGIMPULSIVE.• BIOLARPATIENTSDON’TLIKETHEFEELINGANDISTHEREFORENON-COMPLIANT.

DRUGOFCHOICEFORMANIA

OTHERAGENTSUSEDINTHETREATMENTOFBIPOLARDISORDER

• DEPAKOTE– VALPROICACID• TEGRETOL– CARBAMAZEPINE• TRILEPTAL– OXCARBAZEPINE• LAMICTAL– LAMOTRIGINE– MAINLYFORBIPOLAR11• SECONDGENERATIONANTIPSYCHOTICAGENTS• ABILIFY–ARIPIPRAZOLE• OLANZAPINE-ZYPREXA• RISPERIDONE-RISPERDAL• QUETIAPINE-SEROQUEL

EXPLANATIONSOFMOAOFANTIEPILEPTIC

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EVALUATIONCASESTUDY

• RODNEYISA24YEAROLDMAN,THATWASDIAGNOSEDWITHDEPRESSIVESYMPTOMS,ANDWENTTOHISPCPCOMPLAININGOFNOTBEINGABLETOSLEEPFORAFEWDAYSANDLOWENERGYANDTEARFULMOSTDAYS.HECAN’TEXPLAINWHYHEISSOTEARFUL.HISPCPPRESCRIBEDSERTRALINEFORHIMWITHASLOWGRADUALINCREASEDINDOSE.TWOWEEKSLATER,HEISOUTONTHENEIGHBOURSLAWNSWIMMINGINTHENUDEWITHOUTANYPOOL.THEPOLICEISCALLEDANDHEWASBAKERACTEDTOAPSYCHIATRICWARDFOR3DAYSOBSERVATION.WHATISPROBABBLYRODNEY’SDIAGNOSIS?• A)BIPOLAR1DISORDER• B)BIPOLARCPSYCHOTICFEATURES• C)BIPOLAR11DISORDER• D)DEPESSION

EVALUATIONCASESTUDY

• FROMHISDIFFERENTIALDIAGNOSISWHATMEDICATIONSSHOULDRODNEYBETREATEDWITHATTHISTIME.• A)LAMICTAL• B)PROPRANOLOL• C)LITHIUM• D)ARIPIPRAZOLE• IFRODNEYISTREATEDWITHLITHIUMWHATMONITORINGISNECESSARYFORNEEDEDFORTHISMEDICATION?• A)LITHIUMLEVELIN5DAYS• B)LITHIUMLEVELIN2DAYS• C)LITHIUMLEVELIN2WEEKS• D)LITHIUMLEVELIN6MONTHS

SCHIZOPHRENIA

• COMEONINTHELATETEENTOEARLYTWENTIES• ITCANOCCURREDINMALE:FEMALEEQUALLY,• CANBEDUETOHERIDITARY• AFFECTS1%OFTHEPOPULATION,• ITCANBEDUETOEXPOSUREFROMCANNABISANDMETHAMPHETMINES

CPNP2016-2017PG586

SCHIZOPHRENIA

• TYPESOFSYMPTOMS• POSITIVE• HALLUCINATIONS• DELUSION• MOVEMENTDISORDER• NEGATIVE• LOSSOFINTEREST• LACKOFEMOTIONS• SOCIALWITHDRAWAL• COGNITIVE• PROBLEMSMAKINGDESIONS• MEMORYPROBLEMS

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TREATMENTOFSCHIZOPHRENIA

• USEOFEITHERFIRSTGENERATIONANTIPSYCHOTICAGENTS• Haloperidol• Chlorpromazine• Fluphenazine• Perphenazine• Thorazine• OR• USEOFSECONDGENERATIONANTIPSYCHOTICAGENTS• RISPERIDONE

• ARIPIPRAZOLE

• OLANZAPINE

• CLOZAPINE

TREATMENTOFSCHIZOPHRENIA

• THECHOICETOTREATSCHIZOPHRENIA,NEEDSTOLOOKATTHEENTIREINDIVIDUAL,BEFORECHOOSINGANANTIPSYCHOTICAGENT.• NEEDTOLOOKAT:• MEDICALHX• HEIGHT,WEIGHT,BMI• ALLERGIES• RACE• PREVIOUSUSEOFANTIPSYCHOTICANDWHATWORKED• FAMILYHXANDWHATMEDICATIONWORKEDINTHEPASTINOTHERFAMILYMEMBERS• AGEOFTHEPATIENT.

POSSIBLEADVERSEEFFECTSOFATYPICALANTIPSYCHOTICDRUGS EVALUATIONCASESTUDY

• ASTUDENTISFOUNDWALKINGTHEROADINNEWYORKINTHEDEADOFWINTERINABATHINGSHORTS,WHENASKEDWHATHEISDOINGHESAYSHEISWALKINGTOTHEBEACH.HEWASPICKUPBYTHEPOLICEANDCARRIEDINFOREVALUATION.ITWASDISCOVEREDTHATHEWASINHISJUNIORYEAROFCOLLEGEANDALLOFASUDDENOVERTHELASTSIXMONTHSHEBEGANBEHAVINGWEIRDTOHISCLASSMATES.WHATISONEOFTHEFIRSTBLOODTESTTHATHEHASTOBEDONE?• A)EKG• B)UDS• C)CHEM8• D)CBC

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EVALUATIONSCASESTUDY:

• ISTHEREATESTFORSCHIZOPHRENIA• A)TRUE• B)FALSE

• SAMHASJUSTBEENDIAGNOSEDWITHSCHIZOPHRENIAAFTERAYEAROFCONTINUOUSSYMPTOMS.HEISOVERWEIGHT,ANDISATYPE1DIABETIC.WHICHAGENTWOULDBEAGOODCHOICETOSTARTSAMONANDTOCONTINUEFORCONTINUOUSTHERAPY?• A)OLANZAPINE B)HALDOL• C)ARIPIPRAZOLE D)QUETIAPINE

PERSONALITYDISORDERS

• COMESINTHREEMAINGROUPSANDJUSTADDSTOTHEFURTHERCOMPLICATIONOFDIAGNOSISWITHMENTALHEALTHILLNESS.• CLUSTERA– ODD• CLUSTERB- DRAMATIC• CLUSTERC– ANXIOUSORFEARFUL

PERSONALITYDISORDER• JUSTAFURTHERDEMONSTRATIONOFTHEDIFFERENTTYPESOFPERSONALITIES.

ABUSEOFDRUGSANDALCOHOL

• WHYALCOHOLISTHEMOSTABUSEDRUGALONGWITHNICOTINE• MOSTPEOPLEWITHANXIETYORDEPRESSIVESYMPTOMSDON’TWANTTOADMITTHATSOMETHINGISWRONG• SOINSTEADTHEYBEGINWITHAGLASSOFWINETOLOOSENUP,THENMAYBE2-3ANDBEFOREYOUKNOWIT,THEENTIREBOTTLE.BUTASFARASTHEYARECONCERN,THEYARESTILLINCONTROL.• NICOTINETENDSTOHELPWITHANXIETESANDATTHESAMETIMEADDTOANXIETYIFYOUTRYTOREDUCETHEAMOUNTYOUTAKE.• ITISVERYADDICTIVEANDQUICKLYBECOMEADDICTIVETOTHEPRODUCT.

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ABUSEOFDRUGSANDALCOHOL DURGSOFABUSE

• COCAINECAUSECARDIACPROBLEMS• STROKES• SEIZURES• HEADACHES• DEATH• EXTREMEWEIGHTLOSS• EFFECTSONTHEMENTALCAPACITY

ABUSEOFDRUGSANDALCOHOL

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DRUGSOFABUSE

• DIFFCULTYPAYINGATTENTION• AMOTIVATION• LOSSOFSHORTTERMMEMORY• INCREASEDHEARTRATE• SADNESSORFEARFULNESS• ANXIETYANDPANIC

METHAMPHETAMINEEFFECTSONTHEBODY.

WHATDOESEDUCATIONDOFORVETERANS

• FIRSTWEDOEDUCATIOONALCLASSESON• OPIODSAFETY• CIGARETTECESSATION• SUBSTANCEABUSE• POSTTRAUMATICDISORDER

• THEFOURWEEKSCLASSESSTARTWITH:• ONEWEEKINTRODUCTIONTOSUBSTANCEABUSEORPTSD• 2ND WEEK– SYMPTOMSANDEFFECTSONTHEBODYSYSTEMS• 3RD WEEK- TREATMENTOFEITHERSAORPTSD• 4TH WEEK– LIVINGWITHANDCOPINGWITHADIAGNOSISOFSAORPTSD.

WHATDOEDUCATIONDOFORVETERANS

• MOSTVETERANSLIKETHEFACTTHATTHEYARELEARNINGABOUTTHEMEDICATIONSTHATAREBEINGUSEDANDHOWTHEYWORKTOHELPWITHTHECONDITION.• THESAMEWAYTHATTHEPHARMACISTHASBEENINSTRUMENTALINEDUCATINGTHEPUBLICABOUTDIABETESANDHYPERTENSION.• VETERANSNEEDEDUCATIONABOUTTHEIRSYSMPTOMSANDWHATEFFECTSTHEDRUGSOFABUSEANDTHEDRUGSTHATARECONVENTIONALAGENTSHAVEONTHEIRBODIES.• ONEQUESTIONSARETHEYSUBSTITUTINGONEDRUGOFABUSEFORANOTHERDRUGOFABUSEANDWEDEFINITELYEXPLAINSTHEMECHANISMOFACTIONS• THEYALSOWANTTOKNOWIFTHEYWILLBEABLETOSTOPTHEMEDICATIONANDWHEN.

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WHATDOESEDUCATIONDOFORTHEPUBLIC

• EDUCATIONMAKESTHEVETERANMOREINFORMABOUTBOTHTHECONDITIONANDTHETREATMENTOFTHECONDITIONS• ITMAKESTHEMAWAREOFPOSSIBLESIDEEFFECTSANDWHYTHEIROCCURANDWHATAGENTSMIGHTBEANALTERNATIVEFORTREATMENTOFTHESIDEEFFECTS.• FORSSRIINDUCEDSEXUALSIDEEFFECTS,WECOULDRECOMMENDTALKINGTOTHEYDOCTORSABOUTCHANGINGTHEAGENTTOANOTHERANTIDEPRESSANTSUCHASBUPROPION• ORTAKINGASEROTONERGISTAGONIST– CYPROHEPTADINEABOUT2HRBEFORESEXUALSIDEEFFECT.• THEUSEOFDRUGOFABUSETOTREATPTSDISUSUALLYAOTCEFFECTTOTREATTHEPROBLEM,BUTPRODUCESAWORSEREACTION.

EVALUATION

• VETERANCAMEINTOEMERGENCYROOMCOMPLAININGOFSUICIDALIDEATIONS,WITHAPLANTOJUMPINFRONTOFACAR.COMPLAINSOFHOMELESSNESS,COCAINEANDALCOHOLABUSEANDHEHASNOPLACETOGO,COMPLAINSOFDEPRESSION,LONLINESSANDTEARFULFORPASTMONTH,AFTERWIFEHASLEFTHIM.HISUDSWASPOSITIVEFORCOCAINE,ALCOHOLANDBENZOS.• WHATISTHEMAINCAUSEOFHISDEPRESSION.• A)HOMELESSNESS• B)WIFELEFTHIM• C)DRUGSANDALCOHOL• D)ALLOFTHEABOVE.

EVALUATION

• WHATDIAGNOSISSHOULDHEBETREATEDFORFIRST?• A)ALCOHOLWITHDRAWAL• B)COCAINEWITHDRAWAL• C)DEPRESSION• D)AANDB

WHATISTHEFIRSTAGENTSWILLBEUSEDTOTREATALCOHOLWITHDRAWAL?A) LORAZEPAMB) CLONIDINEC) NAPROXEND) ALLOFTHEABOVE

TYPESOFOTCAGENTSUSEDFORMENTALILLNESS• ST.JOHN’SWORT• CHAMOMILE• LEMONBALM• ROSEMARY• VALERIAN• SAMe• FOLATEANDL-METHYLFOLATE• OMEGA-3FATTYACIDS

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TYPESOFOTCMEDICATIONSFORMENTALILLNESS

• ST.JOHN’SWORT-• Inhibits5-HT,NEandDAtransporter• Alsoweaknon-selectiveinhibitionofMAO• Dose300mgdaily• CaninteractwithotherSSRIorSNRItoproduceSerotoninsyndrome.• Shouldnotbeusedwithotherconventionalagents

• SAMe–• MethyldonorinthesynthesisofdopamineandSerotonin.• Dose– 800-1600mgperdayorIM400mg.• NotregulatedbyFDA• Usedfordepression,veryexpensive.

TYPESOFOTCAGENTSUSEDFORMENTALILLNESS

• OMEGA-3FATTYACIDS–• Containseicosapentaenoicacid(EPA)docosahexaenoicacid(DHA)-• Doserangefrom1– 9gramsperday.• Adverseeffects– GIupset,diarrhea,constipation.• Useformoodstabilizerandasaantidepressant

Magnesiumhydroxide-Helpsregulatecalcium,copper,zinc,potassium,vitamindlevelsUsedforanxiety,insomnia,headache,irritability,HTN,headachesActivatesco-enzymes

OTCAGENTS

• AGENTSTHATCANBEUSEDFORGAD• PASSIONFRUITFLOWER• KAVA• CHAMOMILE• VALERIAN• GINGER• LICORICE

HERBSANDOTCAGENTS

• KAVAROOT–• ADRINKPREPAREDFORUSEINANXIETY,INSOMNIA,• ENHANCEDLIGANDBINDINGTOGABAARECEPTORS• ACTSTOELEVATEMOOD,WELLBEING• KRATOMFOUNDINSPICEANDVARIOUSOTCDRUGS.

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HERBSANDOTCAGENTS

• PASSIONFRUIT– MADEINTOADRINK• SEDATIVEEFFECT• CALMING• CANBEUSEDFORGAD

INTERACTIONBETWEENOTCANDCONVENTIONALMEDICATIONS

• KAVA– CANCAUSELIVEDAMAGEANDLIVERTOXICITY• ST.JOHN’SWORTANDSSRI– MAYLEADTOSEROTONINSYNDROME• SIGNIFICANTINTERACTIONSWITHOTHERANTIDEPRESSANTS• SHOULDNOTUSEST.JOHN’SWORTWITHSSRI’S,TCA,ORMAOI’S• OMEGAFATTYACIDSMAYINTERACTWITHSSRIANDANTICOAGULANTTOINCREASEDTHERISKOFBLEEDING.• PASSIONFLOWERWITHOTHERSEDATIVES,ANTICONVULSANT,TCA,ANDANTICONVULSANT.• CHAMOMILEINTERACTIONWITHWARFARINANDCYCLOSPORINE–• DERMATITIS

INTERACTIONSWITHOTCANDCONVENTIONALMEDICATIONS

• BEWAREOFTHETYPEOFALDULTERANTSINPRODUCTS.• WHETHERITWASTHELEAF,BARK,ORROOTCOULDMAKETHEDIFFERENCEINPOTENCY.• INTERACTIONSWITHCONVENTIONALAGENTS• PLEASEUSEONETYPEOFAGENTSEITHERHERBALORCONVENTIONALTHERAPY• BEWAREOFHERBALAGENTSTHATCUREEVERYTHING,KNOWINGTHATEVERYHERBANDMEDICATIONALWAYSHAVESOMEADVERSEEFFECTS.• BEWAREOFHERBALMEDICATIONSTHATSTATENOADVERSEEFFECTS,MAYBENOTDOINGANYTHINGEITHER.

EVALUATION- CASESTUDY

• APATIENTCOMESTOTHEDRUGSTORECOMPLAININGOFSEVEREANXIETYSINCEBEGINNINGTOTAKEST.JOHN’SWORTABOUTTWOWEEKSAGO.SHEISTAKING3TABLETSADAY,ANDISNOTSLEEPINGASGOODWORSETHANWHENSHEBEGANTAKINGTHEST.JOHN’SWORT.• WHATDOYOUTELLTHISPATIENTTODO?• A)STOPTAKINGTHETABLETS• B)REDUCETHEDOSETO2TABLETSADAY• C)REDUCETHEDOSETO1TABLETADAY• D)STOPTAKINGMEDICATIONFORAWEEKANDTHENRESTARTAGAIN.

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EVALUATION– CASESTUDY

• AVETERANCOMESINTOTHEDRUGSTOREWANTINGSOMETHINGFORSLEEP.HECAN’TSLEEPVERYWELLANDISVERYIRRITABLEINTHEMORNING.WHATDORECOMMENDTOTHISVETERAN?• A)DIPHENHYDRAMNE25MGPOATBEDTIME• B)DOXYLAMINE25MGPOATBEDTIME• C)VALERIANTEAATBEDTIME• D)REFERTOMENTALHEALTHCOUNSELLOR

• TWOWEEKSLATERHECOMESBACKANDCOMPLAINSTHATHEISWAKINGUPWITHNIGHTMARESANDCAN’TGETBACKTOSLEEP,HISIRRITABILITYISWORSE,ANDHISWIFEWANTSTOLEAVEHIM.• A)INCREASEDOSEOFSLEEPAID• B)REFERTOPCPDOCTOR• C)REFERTOMENTALHEALTHDOCTOR• D)RECOMMENDKAVATEA

EVALUATIONCASESTUDY

• VETERANGOESTOHISMENTALHEALTHPHYSCIAN,WHATWOULDYOUEXPECTTHATHISPSYCHIATRISTWOULDGIVETOTHISVETERANFORHISNIGHTMARES?• A)PRAZOSIN• B)ARIPIPRAZOLE• C)SERTRALINE• D)PROPRANOL.• WHATWOULDYOUEXPECTHISPSYCHIATRISTTOGIVEHIMFORHISANXIETY?• A)PRAZOSIN• B)ARIPIPRAZOLE• C)SERTRALINE• D)PROPRANOLOL

EVALUATIONCASESTUDY

• THEVETERANCOMESBACKTOTHEPHARMACYCOMPLAININGOFSTILLHAVINGSUICIDALIDEATIONSAFTER2WEEKSOFTHERAPY.WhatSHOULDTHEPHARMACISTADVICETHEVETERAN?• A)STOPTAKINGMEDICATION• B)CONTACTMENTALHEALTHPHYSICIAN• C)INCREASETHEDOSEOFSERTRALINE• D)CONTINUETAKINGMEDICATIONSASTHEMEDICATIONMAYTAKE6WEEKSTOHAVEANEFFECT.

STIGMA

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QUESTIONSANDANSWERSECTION REFERENCES

• 1)CPNP2016-2017Anxietyandanxietyrelateddisorderspg.1-79.• 2)CPNP2016-2017Bipolardisorderpg.127-181.• 3)CPNP2016-2017;Depression,pg.181-243• 4)CPNP2016-2017;Schizophreniaspectrumandotherpsychoticdisorders,pg.579– 645• www.SAMHSA.gov.Treatmentofmentaldisorders,lastupdated10/27/2015• Collingwood.J.(2016).NaturalandherbalSupplementsforcommonMentalDisorders.Psych.Central.Retrievedfromhttps://psychcentral.com/lib/natural-and-herbal-supplements-for-common-mental-disorders/• Eversole.g.(2017)HerbsforTreatmentofEmotionalandMentalstates,retrievedfromwww.alternativementalhealth.com• FreemanMP,LakeJ,ComplimentaryandAlternativeMedicineinMajorDepressivedisorder:TheAmericanPsychiatricAssociationsTaskForceReport.J.Clinpsychiatry,2010june71(6)669-680.