checklist for autism in toddlers third edition (chat-3) for chinese children – hong kong study...

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Checklist for Autism in Toddlers Checklist for Autism in Toddlers Third Edition (CHAT-3) for Third Edition (CHAT-3) for Chinese Children – Hong Kong Chinese Children – Hong Kong Study Study Principle Investigator Principle Investigator : Prof Virginia : Prof Virginia Wong Wong Co-Investigators Co-Investigators : : Dr Cheuk-Wing Fung Dr Cheuk-Wing Fung Dr Brian Hon-Yin Dr Brian Hon-Yin Chung Chung Dr Wing-Cheong Lee Dr Wing-Cheong Lee Dr Joy Lok-Sum Leung Dr Joy Lok-Sum Leung Ms Nancy Tsang Ms Nancy Tsang Ms Stella Hui Ms Stella Hui

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Page 1: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Checklist for Autism in Toddlers Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Third Edition (CHAT-3) for Chinese

Children – Hong Kong StudyChildren – Hong Kong Study

Checklist for Autism in Toddlers Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Third Edition (CHAT-3) for Chinese

Children – Hong Kong StudyChildren – Hong Kong StudyPrinciple InvestigatorPrinciple Investigator: Prof Virginia Wong: Prof Virginia Wong

Co-InvestigatorsCo-Investigators:: Dr Cheuk-Wing FungDr Cheuk-Wing FungDr Brian Hon-Yin ChungDr Brian Hon-Yin ChungDr Wing-Cheong Lee Dr Wing-Cheong Lee Dr Joy Lok-Sum Leung Dr Joy Lok-Sum Leung Ms Nancy TsangMs Nancy TsangMs Stella HuiMs Stella Hui

Page 2: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Research Background (1)

• Autistic disorder affects 5-30 in 10,000 of population

• most beneficial intervention : early and intensive special education

Page 3: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Research Background (2)

• Checklist for Autism in Toddlers– A screening tool for prospective

identification of autistic cases at 18-months of age (Baron-Cohen 1992)

• Modified Checklist for Autism in Toddlers (Robins et al (2001) )– 18 to 24-months of age

Page 4: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Research Background (3)

• Symbolic Play Test (Second Edition) to estimate the mental age– an adjunctive tool to understand

development of subjects– 4 separate situations – subject is allowed to play with the standard

sets of miniature toys with minimal prompting

Page 5: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Objectives (1)• To test the validity and reliability (internal

consistency and inter-rater reliability) of the new CHAT-3 in Chinese children in Hong Kong

• Any items that can best discriminate the autistic development will be sought

• To determine the most suitable cut-off criteria and risk stratification from the graduated scores of CHAT-3

Page 6: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Objectives (2)• To examine the utility of CHAT, M-CHAT and

CHAT-3• Consistency and accuracy between the

three screening tools • To test the applicability of Symbolic Play

Test in the Chinese population in determining the mental maturity of children

• To explore the possibility of CHAT-3 for population-wide or targeted high risk group screening.

Page 7: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Study method and Procedure:

• Cross-Sectional

• Subject:– Chinese population– Children aged between 18 months and 6 years old 

– In the fieldtrips up to 19/06, we have interviewed 109 children.

– Normal nurseries: 31 – EETC (Heep Kong Society): 78 – (Among the 109 children, the demographic data of 17 children is not

available)

Page 8: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Study method and Procedure:

• Method– Written consent obtained before the interview– Demographic data – Self-administered Part A questionnaire

– Tests:1. Checklist for Autism in Toddlers 3rd Edition (CHAT-3)2. Symbolic Play Test3. Reynell4. The Functional Independence Measure (WeeFIM)

– We conducted tests 1-3 in the children of normal nursery (as the parents are present), and conducted all the 4 tests in the children of EETC.

Page 9: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Study method and Procedure

• Schedule:– 29/4- First meeting and interview– 28/5- Briefing session– 28-29/5-1st field trip (Portland Street)– 6/6- Workshop: training and inter-rater c

orrelation

Page 10: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Study Method and Procedure• Schedule

– 10/6- Toys collection, inter-rater correlation

– 11-25/6- Field trip and data entry– 17/6- mid- evaluation and inter-rater

correlation – 21-27/6- Data analysis– 27/6- Presentation

Page 11: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

                                                                                                                                                 

Toy Toy CollectionCollection

Page 12: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Field Trip

Tam To Centre (EETC)

SKH St Thomas DC

Page 13: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

CHAT-3 Centre Visit Schedule

Date Centre Type 07/06/2002 Jessie & Thomas Tam Centr

eEETC

11/06/2002 SKH St Thomas DC Normal Nursery

Leung King Centre EETC

12/06/2002 Cheerland DN & DC Normal Nursery

13/06/2002 Jockey Club Centre EETC

Pak Tin Centre EETC

Shun Lee Centre EETC

Page 14: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

CHAT-3 Centre Visit Schedule (continue)

Date Centre Type

14/06/2002 Cheerland DN & DC Normal Nursery

Kwok Yip Lin Houn Cnetre EETC

17/02/2002 St James Settlement Kathleen McDonall CCC

Normal Nursery

18/02/2002 Jessie & Thomas Tam Centre

EETC

19/02/2002 St James Settlement Kathleen McDonall CCC

Normal Nursery

24/02/2002 HKSPC Portland Street DC Normal Nursery

25/02/2002 HKSPC Chan Kwan Biu Mem. Foundation DC

Normal Nursery

HKSPC Esther Lee DC Normal Nursery

Page 15: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Data Analysis: 21 June, 2002Data Analysis: 21 June, 2002

Page 16: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Study method and Procedure:• Analysis

– interrater correlation (>0.95) by taking data from same parents at least by 2 interviewers

• 100% was attained for Chat B and Symbolic Play Test

– Grouped according to • chronological and mental age• status of health and diagnosis (autism / PDD, developmental del

ay, cerebral palsy, multiple handicaps and normal)

– Double-blinded and controlled paired up

Page 17: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Study method and Procedure:

• Analysis (continue)– For children who have been diagnosed as AD or

PDD, results of CHAT-3 are compared with the previously charted diagnosis to show the validity

– For those who hasn’t been previously diagnosed as PDD / AD but picked up by CHAT-3 will be assessed using Autism Diagnostic Interview-Revised (AIDR, Catherine Lord et al (1994)) to confirm the diagnosis

Page 18: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Result: Chronological Age distribution of the

subjects:•All the children are aged between 18 months and 6 years old.•Youngest: 18 months old•Eldest: 59 months old•Aged between 18 and 36 months: 60.9%

Age at test (mos)

60.0

57.5

55.0

52.5

50.0

47.5

45.0

42.5

40.0

37.5

35.0

32.5

30.0

27.5

25.0

22.5

20.0

17.5

Age distribution of the subjects (up to 19/06)12

10

8

6

4

2

0

Std. Dev = 9.77

Mean = 34.9

N = 92.00

Page 19: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Symbolic Play Test - Age

SPT (Age)

Symbolic Play Test - Age (months)12

10

8

6

4

2

0

Std. Dev = 7.27

Mean = 25.0

N = 109.00

Page 20: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Reynell - Age

Reynell Verbal Expression - Age (yr.mo)

verbal exp

4.095

4.040

4.010

3.600

3.105

3.080

3.040

3.020

3.000

2.100

2.080

2.060

2.030

2.010

1.100

1.080

1.030

1.010

Missing

Co

un

t

10

8

6

4

2

0

Reynell Expressive Expression - Age (yr.mo)

expressive exp

6.550

4.055

4.005

3.100

3.060

3.020

2.110

2.080

2.050

2.010

1.100

1.070

1.030

1.000

MissingC

ou

nt

12

10

8

6

4

2

0

Page 21: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Result:

•Boys: 66

•Girls: 43

• Gender

Boys

Girls

Boys Girls

Page 22: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Result: DiagnosisDiagnosis No. of subject Percentag

eMental retardation

or delayed development

54 51.4%

Cerebral palsy 1 1.0%

Pervasive developmental

disorders (include autism)

3 2.9%

Multiple handicaps 4 3.8%

Normal 43 41%

Page 23: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Handedness of the subjects

Handedness

bilateral

left

right

Missing

Page 24: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Head Circumference of the subjects

Head circumference (cm)

>51

46-50.99

41-45.99

<=40.99

Missing

Page 25: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Demographic Data of Father

Occupation of father

Unskilled

Semi-skilled

Skilled - Maual and

Intermediate

Professional

Missing

Eduction level of father

Primary school (P.6)

Secondary school (F.Matriculate / Diplom

University degree or

Missing

Page 26: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Demographic Data of Mother

Occupation of mother

Unskilled

Semi-skilled

Skilled - Manual and

Intermediate

Professional

Missing

Eduction level of mother

No official educatio

Primary school (P.6)

Secondary school (F.

Matriculate / Diplom

University degree or

Missing

Page 27: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Domestic helper

Domestic Helper

yes

No

Missing

Page 28: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

CHAT-3CHAT-3CHAT-3CHAT-3

Page 29: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

CHAT • 1. Results of CHAT A

• 2. Results of CHAT B

• 3. Internal consistency of CHAT

Page 30: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

CHAT A • Difference between normal ,autistic and

developmental delay subjects in:

• 1. Total scores

• 2. Scores in the 6 discriminative items

Page 31: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Notes

• Questions 1 and 16 are buffer questions • those who fail either of the 2 buffer

questions are excluded from the analysis ;

• There are 5 normal and 9 developmental delay subjects being excluded

Page 32: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Failing definition • CHAT A : fail 3 or more questions in

the whole chat A

• The 6 discriminative items : fail 2 or more questions among the six

Page 33: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Total scores - normal subjects

SUM23

2 5.3 6.3 6.31 2.6 3.1 9.41 2.6 3.1 12.54 10.5 12.5 25.02 5.3 6.3 31.38 21.1 25.0 56.3

10 26.3 31.3 87.53 7.9 9.4 96.91 2.6 3.1 100.0

32 84.2 100.06 15.8

38 100.0

14.0015.0016.0017.0018.0019.0020.0021.0022.00Total

Valid

SystemMissingTotal

Frequency Percent Valid PercentCumulative

Percent

SUM23

SUM23

22.00

21.00

20.00

19.00

18.00

17.00

16.00

15.00

14.00Frequency

12

10

8

6

4

2

0

Page 34: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Failing rate of normal subjects in CHAT A

PASS23

28 73.7 87.5 87.54 10.5 12.5 100.0

32 84.2 100.06 15.8

38 100.0

.001.00Total

Valid

SystemMissingTotal

Frequency Percent Valid PercentCumulative

Percent

PASS23

1.00.00MissingPercent

80

60

40

20

0

73.7% of normal subjects fail chat A

Page 35: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Results of normal subjects in the six

discriminative items

SUM6Q

1 2.6 2.9 2.91 2.6 2.9 5.76 15.8 17.1 22.9

27 71.1 77.1 100.035 92.1 100.03 7.9

38 100.0

3.004.005.006.00Total

Valid

SystemMissingTotal

Frequency Percent Valid PercentCumulative

Percent

SUM6Q

SUM6Q

6.005.004.003.00

Frequency

30

20

10

0

Page 36: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Failing rate of normal in the 6 discriminative

items

PASS6Q

2 5.3 5.7 5.733 86.8 94.3 100.035 92.1 100.03 7.9

38 100.0

.001.00Total

Valid

SystemMissingTotal

Frequency Percent Valid PercentCumulative

Percent

PASS6Q

1.00.00Missing

Percent

100

80

60

40

20

0

5.3 % of normal fail the 6 items

Page 37: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Total scores - autistic subjects

SUM23

SUM23

18.009.007.00Frequency

1.2

1.0

.8

.6

.4

.2

0.0

SUM23

1 33.3 33.3 33.31 33.3 33.3 66.71 33.3 33.3 100.03 100.0 100.0

7.009.0018.00Total

ValidFrequency Percent Valid Percent

CumulativePercent

Page 38: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Failing rate of autistic subjects in CHAT A

PASS23

3 100.0 100.0 100.0.00ValidFrequency Percent Valid Percent

CumulativePercent

All autistic subjects fail chat A

Page 39: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Results of autistic subjects in the 6

discriminative items

SUM6Q

SUM6Q

6.001.00.00Frequency

1.2

1.0

.8

.6

.4

.2

0.0

SUM6Q

1 33.3 33.3 33.31 33.3 33.3 66.71 33.3 33.3 100.03 100.0 100.0

.001.006.00Total

ValidFrequency Percent Valid Percent

CumulativePercent

Page 40: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

failing rate of autistic subjects in the 6

discriminative items

PASS6Q

1.00.00Percent

70

60

50

40

30

20

10

0

PASS6Q

2 66.7 66.7 66.71 33.3 33.3 100.03 100.0 100.0

.001.00Total

ValidFrequency Percent Valid Percent

CumulativePercent

66.7 % of autistic subjects fail the 6 items

Page 41: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Total scores - developmental delay

subjects

SUM23

SUM23

22.00

21.00

20.00

19.00

18.00

17.00

16.00

15.00

14.00

13.00

Frequency

16

14

12

10

8

6

4

2

0

SUM23

1 2.0 2.2 2.22 4.0 4.4 6.78 16.0 17.8 24.46 12.0 13.3 37.82 4.0 4.4 42.25 10.0 11.1 53.3

14 28.0 31.1 84.44 8.0 8.9 93.32 4.0 4.4 97.81 2.0 2.2 100.0

45 90.0 100.05 10.0

50 100.0

13.0014.0015.0016.0017.0018.0019.0020.0021.0022.00Total

Valid

SystemMissingTotal

Frequency Percent Valid PercentCumulative

Percent

Page 42: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Failing rate of developmental delay subjects in CHAT A

PASS23

1.00.00MissingPercent

100

80

60

40

20

0

PASS23

42 84.0 93.3 93.33 6.0 6.7 100.0

45 90.0 100.05 10.0

50 100.0

.001.00Total

Valid

SystemMissingTotal

Frequency Percent Valid PercentCumulative

Percent

84 % of developmental delay subjects fail chat A

Page 43: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Results of developmental delay

subjects in the six discriminative items

SUM6Q

SUM6Q

6.005.004.003.002.00Frequency

30

20

10

0

SUM6Q

1 2.0 2.1 2.12 4.0 4.2 6.39 18.0 18.8 25.0

12 24.0 25.0 50.024 48.0 50.0 100.048 96.0 100.02 4.0

50 100.0

2.003.004.005.006.00Total

Valid

SystemMissingTotal

Frequency Percent Valid PercentCumulative

Percent

Page 44: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Failing rate of developmental delay

subjects in the 6 discriminative items

PASS6Q

1.00.00MissingPercent

80

60

40

20

0

PASS6Q

12 24.0 25.0 25.036 72.0 75.0 100.048 96.0 100.02 4.0

50 100.0

.001.00Total

Valid

SystemMissingTotal

Frequency Percent Valid PercentCumulative

Percent

24 % of developmental delay subjects fail the 6 items

Page 45: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Failing rate

• In conclusion, the six items are more sensitive than other questions in discriminating autistic children from normal and developmental delay children

Total 6 questionsNormal 73.7 % 5.3 %Autistic 100% 66.7 %Developmental delay 84 % 24 %

Page 46: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

CHAT B• Difference between normal, delay de

velopment and autistic subjects in:• 1. Eye contact• 2. Gaze monitoring • 3. Pretend play• 4. Protodeclarative pointing

Page 47: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

CHAT B - Q1- Eye contact

Normal subjects

NEWB1

1.00

• Eye contact:• usually, sometimes = Pass (1); • seldom., never = Fail (0)

• All the subjects passed the test.

Page 48: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Autistic Subjects• All the autistic

subjects failed the test.

NEWB1

.00

Page 49: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Delay Development

• Pass = 1 (91.5%)• Fail = 0 (8.5%)

• Conclusion:• All autistic subjects

failed in eye contact, while most of the other subjects passed the test.

1.00

.00

Page 50: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

CHAT B - Q2 - Gaze monitoring

‘ 小明 , 你睇…’ Normal subjects

• Result of Q2 in normal subjects

Fail = 1 (2.3 %)

Pass = 2 (97.7%)

2

1

Page 51: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Autistic subjectsResults

Pass= 2 (66.7%)

Fail = 1 (33.3%)

2

1

Page 52: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Delay Development Results

Pass= 2 ( 96.6% )

Fail = 1 (3.4%)

2

1

Page 53: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

• .

Conclusion

• Gaze monitoring • Most of the normal ( 97.7 %) ,

delay development (96.6%) and autistic subjects (66.7%) pass the test.

• This test may not be sensitive enough to distinguish autistic subjects from others.

Page 54: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Q3 - Pretend Play ‘ 倒茶茶’

Normal subjectsResult of Q3 in normal subjects

3 : yes(90.7%) 2 : simulate only(7%) 1 : no(2.3%)

3

2

1

Page 55: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Autistic subjects

B3 (Y=3, N=1)

2 66.7 66.7 66.71 33.3 33.3 100.03 100.0 100.0

13Total

ValidFrequency Percent Valid Percent

CumulativePercent

Page 56: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Developmental Delay• Yes = 3 (83.1%)• Simulate only = 2

(10.2%)• No = 1 (5.1%)

3

2

1

Missing

Page 57: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Conclusion • Pretend Play• Most normal (90.7%) and delay

development subjects (83.1%) passed the test.

• Most autistic subjects (66.7%) failed the test.

Page 58: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Q4 Protodeclarative pointing

‘ 燈燈呢 ?’ Normal subjects

Result of Q4 in normal subjects

4 : point and look(83.7%) 3 : point only(0%)

2 : look only(11.6%) 1 : no(4.7%)

4

2

1

Page 59: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Autistic subjects

4

2

• Point and look = 4 (33.3%)• Look only = 2 (66.7%)

Page 60: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Developmental Delay• Point and look = 4

(54.2%)• Point only = 3

(1.7%)• Look only = 2

(22.8%)• No = 1 (15.3%)

4

3

2

1

Page 61: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Conclusion

• Protodeclarative Pointing:• Most of the normal (83.7%) and delay

development subjects (54.2%) achieved high scores.

• Most autistic subjects (66.7%) failed in the test.

Page 62: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Q4 First object the child responses

Normal subjects

B4 object (1= light, 2=ball, 3=car, 4=doll)

19 44.2 46.3 46.313 30.2 31.7 78.08 18.6 19.5 97.61 2.3 2.4 100.0

41 95.3 100.02 4.7

43 100.0

LightBallcardollTotal

Valid

99MissingTotal

Frequency Percent Valid PercentCumulative

Percent

Page 63: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Autistic subjects

B4 object (1= light, 2=ball, 3=car, 4=doll)

2 66.7 66.7 66.71 33.3 33.3 100.03 100.0 100.0

LightBallTotal

ValidFrequency Percent Valid Percent

CumulativePercent

Page 64: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Developmental Delay

B4 object (1= light, 2=ball, 3=car, 4=doll)

4 6.8 9.1 9.124 40.7 54.5 63.613 22.0 29.5 93.23 5.1 6.8 100.0

44 74.6 100.015 25.459 100.0

NoneLightBallcarTotal

Valid

99MissingTotal

Frequency Percent Valid PercentCumulative

Percent

Page 65: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Internal consistency of CHAT

• To check the consistence between

• 1. Q7 in part A (A7)and Q4 in part B(B4) , where both focus on protodeclarative pointing

• 2. Q5 in part A(A5) and Q3 in part B(B3), where both focus on pretend play

Page 66: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

• We are checking the consistency seperately for :

• 1. Normal subjects• 2. Autistic subjects• 3. Developmental delay subjects

Page 67: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Normal subjects : A7 and B4

B4 (Y=4, N=1) * NEWA7 Crosstabulation

Count

1 14 4

3 28 313 33 36

124

B4 (Y=4,N=1)

Total

.00 1.00NEWA7

Total

Page 68: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Normal subjects : A5 and B3

NEWA5 * B3 (Y=3, N=1) Crosstabulation

Count

2 21 3 30 341 3 32 36

.001.00

NEWA5

Total

1 2 3B3 (Y=3, N=1)

Total

Page 69: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Autistic subjects : A7 and B4

NEWA7 * B4 (Y=4, N=1) Crosstabulation

Count

2 21 1

2 1 3

.001.00

NEWA7

Total

2 4B4 (Y=4, N=1)

Total

Page 70: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Autistic subjects : A5 and B3

NEWA5 * B3 (Y=3, N=1) Crosstabulation

Count

1 11 1 22 1 3

.001.00

NEWA5

Total

1 3B3 (Y=3, N=1)

Total

Page 71: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Developmental delay subjects : A7 and B4

NEWA7 * B4 (Y=4, N=1) Crosstabulation

Count

3 5 10 184 10 17 317 15 27 49

.001.00

NEWA7

Total

1 2 4B4 (Y=4, N=1)

Total

Page 72: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Developmental delay subjects : A5 and B3

NEWA5 * B3 (Y=3, N=1) Crosstabulation

Count

2 4 62 3 38 432 5 42 49

.001.00

NEWA5

Total

1 2 3B3 (Y=3, N=1)

Total

Page 73: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Symbolic Play TestsSymbolic Play TestsSymbolic Play TestsSymbolic Play Tests

Page 74: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Local table of ‘Age equivalent of

score’Report

CAGE

23.000 2 7.07128.000 1 .33.000 1 .40.500 1 .33.000 1 .34.500 2 2.12129.500 3 6.61433.875 4 5.29737.000 1 .36.000 1 .46.500 1 .32.944 18 6.682

SPT_T910111214161718212223Total

Mean NStd.

Deviation

SPT_T

24222018161412108

CAGE

50

40

30

20

10

Page 75: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Local table of ‘Age equivalent of

score’

Limitations • There are not enough sample in

each age group• The children in normal nurseries

are shy to play with the toys

Page 76: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Local table of ‘Age equivalent of

score’Suggestion:• Follow up of missing data• Continue data collection of normal

children

Page 77: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

A New Symbolic Play A New Symbolic Play TestTest

A New Symbolic Play A New Symbolic Play TestTest

Page 78: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Situation IIICURRENT SPT

• Relates knife or fork to plate

• Relates fork, knife, or plate to table

• Relates spoon, fork, knife, or plate to doll

NEW SPT• Relates chopsticks

to bowl• Relates chopsticks

or bowl to table• Relates chopsticks

or bowl to doll

Page 79: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

SPT Situation IIIDrawbacks of the new set:• The size of chopsticks and bowl

are not proportional to other toys.• The chopsticks and bowl are

bigger and attract children to play with them.

Page 80: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

SPT Situation IIISuggestion:• Modify the size of toys

Page 81: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Situation IVCURRENT SPT

• Moves tractor or trailer along

• Relates log(s) to tractor, trailer or man

• Lines up tractor and trailer

• Attaches tractor to trailer

NEW SPT

• Moves train along

• Put train cars on rail

• Lines up train cars

• Attaches train cars

Page 82: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

SPT Situation IVDrawbacks of new set:• It cannot replace the current one

because there are no man and logs.• Some new items cannot be

compared with that of current items: Put engine on either end Put train cars on rail

Page 83: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

SPT Situation IVSuggestion:• Modify the design of toys

Page 84: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Current: Relates knife or fork to plateNew: Relates chopsticks to bowl

New0 1 Total

EETC Current

0 12 21 331 4 24 28

Total 16 45 61

Nursery Current

0 7 11 181 3 10 13

Total 10 21 31

Overall*

Current

0 19 32 511 7 34 41

Total 26 66 92

* p<0.05 ** p<0.01

Page 85: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Current: Relates fork, knife, or plate to table New: Relates chopsticks or bowl to table

New0 1 Total

EETC* Current

0 17 14 311 7 22 29

Total 24 36 60

Nursery*

Current

0 7 8 151 2 14 16

Total 9 22 31

Overall**

Current

0 24 22 461 9 36 45

Total 33 58 91* p<0.05 ** p<0.01

Page 86: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Current: Relates spoon, fork, knife, or plate to doll New: Relates chopsticks or bowl to doll

New0 1 Total

EETC** Current

0 42 6 481 4 8 12

Total 46 14 60

Nursery*

Current

0 18 4 221 4 5 9

Total 22 9 31

Overall**

Current

0 60 10 701 8 13 21

Total 68 23 91

* p<0.05 ** p<0.01

Page 87: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Current: Moves tractor or trailer alongNew: Moves train along

New0 1 Total

EETC Current

0 1 6 71 8 50 58

Total 9 56 65

Nursery Current

0 0 0 01 1 30 31

Total 1 30 31

Overall Current

0 1 6 71 9 80 89

Total 10 86 96

* p<0.05 ** p<0.01

Page 88: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Current: Relates log(s) to tractor, trailer or manNew: Put train cars on rail

New0 1 Total

EETC Current

0 8 9 171 16 31 47

Total 24 40 64

Nursery Current

0 0 7 71 4 20 24

Total 4 27 31

Overall Current

0 8 16 241 20 51 71

Total 28 67 95

* p<0.05 ** p<0.01

Page 89: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Current: Lines up tractor and trailer New: Lines up train cars

New0 1 Total

EETC** Current

0 25 19 441 2 20 22

Total 27 39 66

Nursery Current

0 8 13 211 1 9 10

Total 9 22 31

Overall**

Current

0 33 32 651 3 29 32

Total 36 61 97

* p<0.05 ** p<0.01

Page 90: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Current: Attaches tractor to trailerNew: Attaches tractor to trailer

New0 1 Total

EETC** Current

0 42 13 551 3 8 11

Total 45 21 66

Nursery Current

0 15 12 271 1 3 4

Total 16 15 31

Overall**

Current

0 57 25 821 4 11 15

Total 61 36 97

* p<0.05 ** p<0.01

Page 91: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Mean ScoreCorrelati

onSig.

Situation III

Current

3.480.909 0.000

New 3.92

Situation IV

Current

3.430.768 0.001

New 3.86

TotalCurrent

14.460.961 0.000

New 15.31

Page 92: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Reynell AnalysisReynell AnalysisReynell AnalysisReynell Analysis

Page 93: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Reynell Analysis• Subjects divided into

– Normal children– Children from EETC– Total

Page 94: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Correlation Test• Spearman’s correlation test used• Variables :

– verbal comprehension(Reynell)– Language expression(Reynell)– SPT(age)– Age at test

Page 95: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

NormalCorrelations

1.000 .662** .653** .518**. .000 .000 .004

43 42 42 29.662** 1.000 .703** .597**.000 . .000 .001

42 42 41 28.653** .703** 1.000 .464*.000 .000 . .013

42 41 42 28.518** .597** .464* 1.000.004 .001 .013 .

29 28 28 29

Correlation CoefficientSig. (2-tailed)NCorrelation CoefficientSig. (2-tailed)NCorrelation CoefficientSig. (2-tailed)NCorrelation CoefficientSig. (2-tailed)N

SPT (Age)

verbal exp

expressive exp

Age at test (mos)

Spearman's rhoSPT (Age) verbal expexpressive expAge at test (mos)

Correlation is significant at the .01 level (2-tailed).**. Correlation is significant at the .05 level (2-tailed).*.

Page 96: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Results: Normal• All are statistically significant with p

value smaller than 0.05• All shows positive correlation• All except the correlation between age

and language exp(0.464) shows r >0.5• Strongest correlation between language

exp and verbal comprehension(0.703)

Page 97: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

EETCCorrelations

1.000 .842** .853** .806**. .000 .000 .000

59 59 54 53.842** 1.000 .775** .754**.000 . .000 .000

59 62 55 54.853** .775** 1.000 .902**.000 .000 . .000

54 55 55 54.806** .754** .902** 1.000.000 .000 .000 .

53 54 54 54

Correlation CoefficientSig. (2-tailed)NCorrelation CoefficientSig. (2-tailed)NCorrelation CoefficientSig. (2-tailed)NCorrelation CoefficientSig. (2-tailed)N

Age at test (mos)

SPT (Age)

verbal exp

expressive exp

Spearman's rhoAge at test (mos)SPT (Age) verbal expexpressive exp

Correlation is significant at the .01 level (2-tailed).**.

Page 98: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Result:EETC• All results are statistically significant• All shows positive correlation• All have r >0.7• Best correlation between language expr

ession and verbal comprehension(0.902)• Generally good correlation between age

and SPT , age and Reynell (r>0.8)

Page 99: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

OverallCorrelations

1.000 .734** .731** .650**. .000 .000 .000

92 92 86 85.734** 1.000 .740** .725**.000 . .000 .000

92 109 101 100.731** .740** 1.000 .852**.000 .000 . .000

86 101 101 99.650** .725** .852** 1.000.000 .000 .000 .

85 100 99 100

Correlation CoefficientSig. (2-tailed)NCorrelation CoefficientSig. (2-tailed)NCorrelation CoefficientSig. (2-tailed)NCorrelation CoefficientSig. (2-tailed)N

Age at test (mos)

SPT (Age)

verbal exp

expressive exp

Spearman's rhoAge at test (mos)SPT (Age) verbal expexpressive exp

Correlation is significant at the .01 level (2-tailed).**.

Page 100: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Result: Overall• A combined picture of the results of

normal children and children from EETC• All results are statistically significant• All correlations are positive• All have r > 0.6• Best correlation between language

expression and verbal comprehension

Page 101: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Comment

• Result from EETC shows better correlations than from normal nurseries

• Children perform well in part I of the Reynell likely to do well also in Reynell part II

• Children perform well in SPT also likely to perform well in Reynell

• Older kids generally perform better

Page 102: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

WeeFIMWeeFIMWeeFIMWeeFIM

Page 103: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

WeeFIM• Aims• Subject: all EETC• 3 catagories

– Self Care Domain Rating– Mobility Domain Rating– Cognition Domain Rating

• Total WeeFIM Rating• Method: face-to-face interview

Page 104: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Results• Descriptive data• Method:

– Catagorize– Chi-square test

• Significant (p <0.05)– SPT age– Reynell– Intra-correlation With WeeFIM raw score

Page 105: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Descriptive Data• 8 EETC; 78 Children• 70 valid WeeFIM• Gender: boys (65.7%) & girls (34.3%)• Chronological Age: 70% between 31 to 40 m

• Some are developmental delay (74%)• WF Total: 60% less than 26 months

(According to Western Norm Data)

Page 106: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

WFTOTAL

95.090.0

85.080.0

75.070.0

65.060.0

55.050.0

45.040.0

35.030.0

25.0

WFTOTALFrequency

10

8

6

4

2

0

Std. Dev = 18.16

Mean = 63.8

N = 70.00

Page 107: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Dermographic data with WeeFIM

All are not significant• Gender• Chronological age• Head circumference• Parents’ occupation, education level• Diagnosis• Domestic helper

Page 108: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Chat A with WeeFIM• Not significant

– WF1, WF2, WF3 against Chat A• Reason

– WeeFIM –mainly related to the performance status

Page 109: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

SPT-age with WeeFIM• Significant

– WF1(p=0.001)– WF2 (p=0.05)– WF total

(p=0.001)

• Not significant– WF3 (p=0.089)

• Proposed Reasons:– Expected to be related

to mental age– Subjects with isolated

speech delay– Parents may not

notice in details• At nurseries• At home

– “I haven’t tried it BUT...”

Page 110: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Reynell Verbal with WeeFIM

• All are significant– WF1 (p=0.000)– WF2 (p=0.000)– WF3 (p=0.003)– WF Total

(p=0.000)

Page 111: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Reynell Expression with WeeFIM

• Significant– WF1 (p=0.000)– WF3 (p=0.016)– WF Total

(p=0.000)

• Not significant– WF2 (p=0.082)

• WF2 and Reynell Expression are independently related to age

Page 112: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Intra-correlationWF1 WF2 WF3 WF T

WF1 0.000 0.047 0.000

WF2 0.000 0.001 0.000

WF3 0.047 0.001 0.005

WF T 0.000 0.000 0.005

Page 113: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Problem encountered• Rating is not reliable• Parents may not notice minor items o

r not notice the items questioned in WeeFIM

Page 114: Checklist for Autism in Toddlers Third Edition (CHAT-3) for Chinese Children – Hong Kong Study Principle Investigator: Prof Virginia Wong Co-Investigators:Dr

Video demonstration• Case 1 – prematurity• Case 2 – Prematurity• Case 3 – Preparation