chemical analysis of nutrients and contaminants to ensure ......2 there are various ways in which...

6
To know more please contact us: Customer.Reach@thermofisher.com 1-800-209-7001 Our customers trust their milk to be safe, consistent, and unadulterated. Thermo Fisher ensures to adhere to the food label claims, product consistency, purity, and identifying any contaminants and adulterants. Chemical analysis of nutrients and contaminants to ensure Safe and Pure Milk is Necessary Safe MILK

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Page 1: Chemical analysis of nutrients and contaminants to ensure ......2 There are various ways in which the milk and milk products we consume might become unhealthy. Therefore, quality control

To know more please contact us CustomerReachthermofishercom 1-800-209-7001

Our customers trust their milk to be safe consistent and unadulterated Thermo Fisher ensures to adhere to the food label claims product consistency purity and identifying any contaminants and adulterants

Chemical analysis of nutrients and contaminants to ensure

Safe and Pure Milk is Necessary

Safe MILK

2

There are various ways in which the milk and milk products we consume might become unhealthy Therefore quality control tests are critical to assure adulterant free milk having the right nutrients composition for consumption Thermo Fisher Scientific presents different analytical techniques to study and quantify potential adulterants and necessary nutrients so that the full health benefits of milk and its products can be realized

Following technical notes published using five different techniques cover complete analysis of milk

bull Drug residues might enter milk while medication of cattle for diseases or infections The following technote aims to develop a method to determine the amitraz total residues in milk

bull Harmful pesticides can be transferred to animals via the food chain and get bioaccumulated in animal products like milk Their presence can cause acute as well as chronic effects on humans and may also lead to death in extreme cases Following tech note offers a total solution for the trace-level quantification of 155 pesticide residues in milk using gas chromatography-tandem mass spectrometry

Gas Chromatography-Mass Spectrometry

Determination of Veterinary Drug Residues in Milk by GCMS and GCECD

Large-scale screening and quantitation of 155 pesticide residues in milk usingGC-(EI)-MSMS

3

bull For accurate determination of retinol (vitamin A) cholecalciferol (vitamin D3) and tocopherol (vitamin E) in milk-based Nutritionals such as infant formula adult formula milk yogurt and cheese HPLC method is used this ensures that these foodstuffs contain the labeled amounts

of vitamins

bull The following application note demonstrates that automated solid-phase extraction (SPE) is an efficient technique for concentrating pesticide residues from beverages and other aqueous samples

bull Accurate and comprehensive analysis of fat-soluble nutrients are essential for product labeling nutritional research development and quality control for the food supplements fortified food products and dietary nutrients This application note helps to develop a sensitive and selective HPLC-electrochemical detection (ECD) method for the simultaneous measurement of numerous fat-soluble nutrients in infant formula and milk

High-performance Liquid Chromatography

Pesticides in My BeveragemdashScreening (and Subsequent Quantification) of Pesticides in Beverages Originating from Leaves Grapes Grasses and the Hydrologic Cycle (Tea Wine Milk and Water) Using Automated SPE

Simultaneous Measurement of Vitamins A D E and K Along with CoQ10 and Carotenoids in Multivitamin Tablets Infant Formula and Milk

Simultaneous Determination of Vitamins A E and D3 in Milk-Based Nutritionals by On-Line Two-Dimensional HPLC

4

bull Breast milk is the primary source of nutrition for newborns before they can eat and digest other foods The proteins vitamins and ionic elements such as sodium potassium calcium magnesium chloride and nitrate present in breast milk are essential for infant health By monitoring the concentrations of these ions in breast milk the maternal diet can be adjusted to improve milk quality IC is an efficient means to determine anions even in samples with complex matrixes

bull To meet the demands of the Lactose -intolerant population lactose-free products are commercially produced by enzymatic hydrolysis with lactase 1 However the enzymatic hydrolysis process is not 100 efficient Therefore commercial suppliers need accurate and robust methods to determine lactose concentrations in milk products and residual Lactose is lactose-free products The Application note demonstrate fast separations of Lactose and lactulose in food samples by HPAE-PAD

bull Lactose intolerant individuals use commercially available Lactose-free milk products but these products also contain varying amounts of residual Lactose This application note here describes a sensitive and accurate method to determine Lactose and lactulose in dairy products including lactose-free products using high-performance anion-exchange chromatography with pulsed amperometric detection (HPAE-PAD)

Ion Chromatography

Determination of Lactose is Lactose-Free Milk Products by High-Performance Anion-Exchange Chromatography with Pulsed Amperometric Detection

bull Dicyandiamide is used by farmers to minimize the environmental impact of livestock on land it is also used to make the protein content of food appear higher (ie protein adulteration) Overuse of dicyandiamide can lead to its appearance in dairy products Both reversed-phase HPLC and liquid chromatography-tandem mass spectrometry (LC-MSMS) has been used to quantify dicyandiamide in various matrices

Determination of Dicyandiamide in Milk Powder

Fast Determinations of Lactose and Lactulose in Milk Products Using HPAE-PAD

Determination of Anions in Breast Milk

5

bull Melamine is a nitrogen-rich compound it has been used to fraudulently increase the detected protein level in milk so that the milk can command a higher price The ingestion of Melamine can cause renal complications including kidney and bladder stones and even bladder cancer This application note describes a method of testing infant formula milk for the presence of Melamine

bull Synthetic glucocorticoids are administered to livestock to treat inflammatory diseases and other diseases common to farm animals The presence of glucocorticoid residues in animal-derived food may be harmful to humans The application note helps understand an effective LC-MSMS method to detect eight glucocorticoid residues

bull Apart from the high source of calcium and potassium milk contains several essential elements such as iron copper and zinc Analysis of milk can determine whether milk is meeting the expected nutritional requirements or is lacking alternatively the analysis of trace elements that are toxic in nature can alert us to the possible risk of contamination in milk The application note offers total elemental determinations including iodine for milk and milk products

Liquid Chromatography with Tandem Mass Spectrometry (LC-MSMS)

Inductively Coupled Plasma Mass Spectrometry ICPMS

Detection of Glucocorticoid Residues in Animal-derived Food by HPLC-MSMS Determination of Melamine in Powdered

Milk by LC-MSMS Using a Core Enhanced Technology Solid Core HPLC Column

The Determination of Major and Trace Elements in Milk using ICP-Q-MS

Find out more at thermofishercomfurlFor Research Use Only Not for use in diagnostic procedures copy 2019 Thermo Fisher Scientific Inc All rights reserved All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified ThermofisherIndiaCM_27072020

bull Chloramphenicol (CAP) is a broad-spectrum antibiotic with historical veterinary uses in all significant food-producing animals It has a serious side effects on humans that may cause aplastic anemia and the suspected carcinogen effect This technical note shows a simple rapid and sensitive LC-MSMS method for analyzing chloramphenicol in milk

bull Antibiotics are widely used in animal husbandry primarily for the protection of animals from disease but also as growth promoters The use of LC-MSMS for screening was described in a validated multi-residue screening method to monitor 58 antibiotics in milk This application note describes a multi-residue confirmatory method for the quantitative determination of antibiotics in milk using turbulent flow chromatography coupled to LC-MSMS

bull Phthalates the endocrine active chemicals have been used to adulterate beverages and sports drinks in Taiwan deliberately and phthalates and other plasticizers are widely found as ubiquitous contaminants particularly in fatty foodstuffs This application note describes a method that has been validated for 11 plasticizers in beverages and milk

bull Bioaccumulation of perfluorinated compounds(PFCs) in wildlife and humans have led to efforts to regulate these compounds and have prompted the need for PFC monitoring and risk assignment This application note demonstrates a highly effective accurate and reproducible analysis of six PFCs in human breast milk

Sensitive and accurate Quantitation of perflurinated compounds in Human Breast Milk using selected Reaction monitoring assays by LCMSMS

bull To overcome Vit D deficiency fortification of vitamin D in some dietary sources becomes necessary The intake of excessive amounts of vitamin D can however lead to a potentially dangerous condition In this application note we describe an accessible and comprehensive LC-MSMS method to measure vitamin D levels in infant formula

bull Cowrsquos milk is one of the most common causes of allergic reactions in early life Milk contains approximately three p protein about 80of the milk proteins are caseins The casein fraction is composed of alphaS1-alphaS2-beta- and k-casein of which alpha S1-casein seems to be a significant allergen LC-MSMS methods were developed for milk allergen identification and quantitation in wine using high resolutionaccurate mass and linear ion trap mass spectrometers

Multi-residue Automated Turbulent Flow Online LC-MSMS Method for the Determination of Antibiotics in Milk

Analysis of Plasticizer Contaminants in Beverages and Milk using an Automated System Based on Turbulent-flow Chromatography Coupled to LC-MSMS

Milk Allergen Identification and Quantitation in Wine with LC-MSMS Approaches

Measurement of Vitamin D in Infant Formulas Using Automated Online Sample Preparation with Liquid ChromatographyTandem Mass Spectrometry

Simple and Rapid Analysis of Chloramphenicol in Milk by LC-MSMS

Page 2: Chemical analysis of nutrients and contaminants to ensure ......2 There are various ways in which the milk and milk products we consume might become unhealthy. Therefore, quality control

2

There are various ways in which the milk and milk products we consume might become unhealthy Therefore quality control tests are critical to assure adulterant free milk having the right nutrients composition for consumption Thermo Fisher Scientific presents different analytical techniques to study and quantify potential adulterants and necessary nutrients so that the full health benefits of milk and its products can be realized

Following technical notes published using five different techniques cover complete analysis of milk

bull Drug residues might enter milk while medication of cattle for diseases or infections The following technote aims to develop a method to determine the amitraz total residues in milk

bull Harmful pesticides can be transferred to animals via the food chain and get bioaccumulated in animal products like milk Their presence can cause acute as well as chronic effects on humans and may also lead to death in extreme cases Following tech note offers a total solution for the trace-level quantification of 155 pesticide residues in milk using gas chromatography-tandem mass spectrometry

Gas Chromatography-Mass Spectrometry

Determination of Veterinary Drug Residues in Milk by GCMS and GCECD

Large-scale screening and quantitation of 155 pesticide residues in milk usingGC-(EI)-MSMS

3

bull For accurate determination of retinol (vitamin A) cholecalciferol (vitamin D3) and tocopherol (vitamin E) in milk-based Nutritionals such as infant formula adult formula milk yogurt and cheese HPLC method is used this ensures that these foodstuffs contain the labeled amounts

of vitamins

bull The following application note demonstrates that automated solid-phase extraction (SPE) is an efficient technique for concentrating pesticide residues from beverages and other aqueous samples

bull Accurate and comprehensive analysis of fat-soluble nutrients are essential for product labeling nutritional research development and quality control for the food supplements fortified food products and dietary nutrients This application note helps to develop a sensitive and selective HPLC-electrochemical detection (ECD) method for the simultaneous measurement of numerous fat-soluble nutrients in infant formula and milk

High-performance Liquid Chromatography

Pesticides in My BeveragemdashScreening (and Subsequent Quantification) of Pesticides in Beverages Originating from Leaves Grapes Grasses and the Hydrologic Cycle (Tea Wine Milk and Water) Using Automated SPE

Simultaneous Measurement of Vitamins A D E and K Along with CoQ10 and Carotenoids in Multivitamin Tablets Infant Formula and Milk

Simultaneous Determination of Vitamins A E and D3 in Milk-Based Nutritionals by On-Line Two-Dimensional HPLC

4

bull Breast milk is the primary source of nutrition for newborns before they can eat and digest other foods The proteins vitamins and ionic elements such as sodium potassium calcium magnesium chloride and nitrate present in breast milk are essential for infant health By monitoring the concentrations of these ions in breast milk the maternal diet can be adjusted to improve milk quality IC is an efficient means to determine anions even in samples with complex matrixes

bull To meet the demands of the Lactose -intolerant population lactose-free products are commercially produced by enzymatic hydrolysis with lactase 1 However the enzymatic hydrolysis process is not 100 efficient Therefore commercial suppliers need accurate and robust methods to determine lactose concentrations in milk products and residual Lactose is lactose-free products The Application note demonstrate fast separations of Lactose and lactulose in food samples by HPAE-PAD

bull Lactose intolerant individuals use commercially available Lactose-free milk products but these products also contain varying amounts of residual Lactose This application note here describes a sensitive and accurate method to determine Lactose and lactulose in dairy products including lactose-free products using high-performance anion-exchange chromatography with pulsed amperometric detection (HPAE-PAD)

Ion Chromatography

Determination of Lactose is Lactose-Free Milk Products by High-Performance Anion-Exchange Chromatography with Pulsed Amperometric Detection

bull Dicyandiamide is used by farmers to minimize the environmental impact of livestock on land it is also used to make the protein content of food appear higher (ie protein adulteration) Overuse of dicyandiamide can lead to its appearance in dairy products Both reversed-phase HPLC and liquid chromatography-tandem mass spectrometry (LC-MSMS) has been used to quantify dicyandiamide in various matrices

Determination of Dicyandiamide in Milk Powder

Fast Determinations of Lactose and Lactulose in Milk Products Using HPAE-PAD

Determination of Anions in Breast Milk

5

bull Melamine is a nitrogen-rich compound it has been used to fraudulently increase the detected protein level in milk so that the milk can command a higher price The ingestion of Melamine can cause renal complications including kidney and bladder stones and even bladder cancer This application note describes a method of testing infant formula milk for the presence of Melamine

bull Synthetic glucocorticoids are administered to livestock to treat inflammatory diseases and other diseases common to farm animals The presence of glucocorticoid residues in animal-derived food may be harmful to humans The application note helps understand an effective LC-MSMS method to detect eight glucocorticoid residues

bull Apart from the high source of calcium and potassium milk contains several essential elements such as iron copper and zinc Analysis of milk can determine whether milk is meeting the expected nutritional requirements or is lacking alternatively the analysis of trace elements that are toxic in nature can alert us to the possible risk of contamination in milk The application note offers total elemental determinations including iodine for milk and milk products

Liquid Chromatography with Tandem Mass Spectrometry (LC-MSMS)

Inductively Coupled Plasma Mass Spectrometry ICPMS

Detection of Glucocorticoid Residues in Animal-derived Food by HPLC-MSMS Determination of Melamine in Powdered

Milk by LC-MSMS Using a Core Enhanced Technology Solid Core HPLC Column

The Determination of Major and Trace Elements in Milk using ICP-Q-MS

Find out more at thermofishercomfurlFor Research Use Only Not for use in diagnostic procedures copy 2019 Thermo Fisher Scientific Inc All rights reserved All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified ThermofisherIndiaCM_27072020

bull Chloramphenicol (CAP) is a broad-spectrum antibiotic with historical veterinary uses in all significant food-producing animals It has a serious side effects on humans that may cause aplastic anemia and the suspected carcinogen effect This technical note shows a simple rapid and sensitive LC-MSMS method for analyzing chloramphenicol in milk

bull Antibiotics are widely used in animal husbandry primarily for the protection of animals from disease but also as growth promoters The use of LC-MSMS for screening was described in a validated multi-residue screening method to monitor 58 antibiotics in milk This application note describes a multi-residue confirmatory method for the quantitative determination of antibiotics in milk using turbulent flow chromatography coupled to LC-MSMS

bull Phthalates the endocrine active chemicals have been used to adulterate beverages and sports drinks in Taiwan deliberately and phthalates and other plasticizers are widely found as ubiquitous contaminants particularly in fatty foodstuffs This application note describes a method that has been validated for 11 plasticizers in beverages and milk

bull Bioaccumulation of perfluorinated compounds(PFCs) in wildlife and humans have led to efforts to regulate these compounds and have prompted the need for PFC monitoring and risk assignment This application note demonstrates a highly effective accurate and reproducible analysis of six PFCs in human breast milk

Sensitive and accurate Quantitation of perflurinated compounds in Human Breast Milk using selected Reaction monitoring assays by LCMSMS

bull To overcome Vit D deficiency fortification of vitamin D in some dietary sources becomes necessary The intake of excessive amounts of vitamin D can however lead to a potentially dangerous condition In this application note we describe an accessible and comprehensive LC-MSMS method to measure vitamin D levels in infant formula

bull Cowrsquos milk is one of the most common causes of allergic reactions in early life Milk contains approximately three p protein about 80of the milk proteins are caseins The casein fraction is composed of alphaS1-alphaS2-beta- and k-casein of which alpha S1-casein seems to be a significant allergen LC-MSMS methods were developed for milk allergen identification and quantitation in wine using high resolutionaccurate mass and linear ion trap mass spectrometers

Multi-residue Automated Turbulent Flow Online LC-MSMS Method for the Determination of Antibiotics in Milk

Analysis of Plasticizer Contaminants in Beverages and Milk using an Automated System Based on Turbulent-flow Chromatography Coupled to LC-MSMS

Milk Allergen Identification and Quantitation in Wine with LC-MSMS Approaches

Measurement of Vitamin D in Infant Formulas Using Automated Online Sample Preparation with Liquid ChromatographyTandem Mass Spectrometry

Simple and Rapid Analysis of Chloramphenicol in Milk by LC-MSMS

Page 3: Chemical analysis of nutrients and contaminants to ensure ......2 There are various ways in which the milk and milk products we consume might become unhealthy. Therefore, quality control

3

bull For accurate determination of retinol (vitamin A) cholecalciferol (vitamin D3) and tocopherol (vitamin E) in milk-based Nutritionals such as infant formula adult formula milk yogurt and cheese HPLC method is used this ensures that these foodstuffs contain the labeled amounts

of vitamins

bull The following application note demonstrates that automated solid-phase extraction (SPE) is an efficient technique for concentrating pesticide residues from beverages and other aqueous samples

bull Accurate and comprehensive analysis of fat-soluble nutrients are essential for product labeling nutritional research development and quality control for the food supplements fortified food products and dietary nutrients This application note helps to develop a sensitive and selective HPLC-electrochemical detection (ECD) method for the simultaneous measurement of numerous fat-soluble nutrients in infant formula and milk

High-performance Liquid Chromatography

Pesticides in My BeveragemdashScreening (and Subsequent Quantification) of Pesticides in Beverages Originating from Leaves Grapes Grasses and the Hydrologic Cycle (Tea Wine Milk and Water) Using Automated SPE

Simultaneous Measurement of Vitamins A D E and K Along with CoQ10 and Carotenoids in Multivitamin Tablets Infant Formula and Milk

Simultaneous Determination of Vitamins A E and D3 in Milk-Based Nutritionals by On-Line Two-Dimensional HPLC

4

bull Breast milk is the primary source of nutrition for newborns before they can eat and digest other foods The proteins vitamins and ionic elements such as sodium potassium calcium magnesium chloride and nitrate present in breast milk are essential for infant health By monitoring the concentrations of these ions in breast milk the maternal diet can be adjusted to improve milk quality IC is an efficient means to determine anions even in samples with complex matrixes

bull To meet the demands of the Lactose -intolerant population lactose-free products are commercially produced by enzymatic hydrolysis with lactase 1 However the enzymatic hydrolysis process is not 100 efficient Therefore commercial suppliers need accurate and robust methods to determine lactose concentrations in milk products and residual Lactose is lactose-free products The Application note demonstrate fast separations of Lactose and lactulose in food samples by HPAE-PAD

bull Lactose intolerant individuals use commercially available Lactose-free milk products but these products also contain varying amounts of residual Lactose This application note here describes a sensitive and accurate method to determine Lactose and lactulose in dairy products including lactose-free products using high-performance anion-exchange chromatography with pulsed amperometric detection (HPAE-PAD)

Ion Chromatography

Determination of Lactose is Lactose-Free Milk Products by High-Performance Anion-Exchange Chromatography with Pulsed Amperometric Detection

bull Dicyandiamide is used by farmers to minimize the environmental impact of livestock on land it is also used to make the protein content of food appear higher (ie protein adulteration) Overuse of dicyandiamide can lead to its appearance in dairy products Both reversed-phase HPLC and liquid chromatography-tandem mass spectrometry (LC-MSMS) has been used to quantify dicyandiamide in various matrices

Determination of Dicyandiamide in Milk Powder

Fast Determinations of Lactose and Lactulose in Milk Products Using HPAE-PAD

Determination of Anions in Breast Milk

5

bull Melamine is a nitrogen-rich compound it has been used to fraudulently increase the detected protein level in milk so that the milk can command a higher price The ingestion of Melamine can cause renal complications including kidney and bladder stones and even bladder cancer This application note describes a method of testing infant formula milk for the presence of Melamine

bull Synthetic glucocorticoids are administered to livestock to treat inflammatory diseases and other diseases common to farm animals The presence of glucocorticoid residues in animal-derived food may be harmful to humans The application note helps understand an effective LC-MSMS method to detect eight glucocorticoid residues

bull Apart from the high source of calcium and potassium milk contains several essential elements such as iron copper and zinc Analysis of milk can determine whether milk is meeting the expected nutritional requirements or is lacking alternatively the analysis of trace elements that are toxic in nature can alert us to the possible risk of contamination in milk The application note offers total elemental determinations including iodine for milk and milk products

Liquid Chromatography with Tandem Mass Spectrometry (LC-MSMS)

Inductively Coupled Plasma Mass Spectrometry ICPMS

Detection of Glucocorticoid Residues in Animal-derived Food by HPLC-MSMS Determination of Melamine in Powdered

Milk by LC-MSMS Using a Core Enhanced Technology Solid Core HPLC Column

The Determination of Major and Trace Elements in Milk using ICP-Q-MS

Find out more at thermofishercomfurlFor Research Use Only Not for use in diagnostic procedures copy 2019 Thermo Fisher Scientific Inc All rights reserved All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified ThermofisherIndiaCM_27072020

bull Chloramphenicol (CAP) is a broad-spectrum antibiotic with historical veterinary uses in all significant food-producing animals It has a serious side effects on humans that may cause aplastic anemia and the suspected carcinogen effect This technical note shows a simple rapid and sensitive LC-MSMS method for analyzing chloramphenicol in milk

bull Antibiotics are widely used in animal husbandry primarily for the protection of animals from disease but also as growth promoters The use of LC-MSMS for screening was described in a validated multi-residue screening method to monitor 58 antibiotics in milk This application note describes a multi-residue confirmatory method for the quantitative determination of antibiotics in milk using turbulent flow chromatography coupled to LC-MSMS

bull Phthalates the endocrine active chemicals have been used to adulterate beverages and sports drinks in Taiwan deliberately and phthalates and other plasticizers are widely found as ubiquitous contaminants particularly in fatty foodstuffs This application note describes a method that has been validated for 11 plasticizers in beverages and milk

bull Bioaccumulation of perfluorinated compounds(PFCs) in wildlife and humans have led to efforts to regulate these compounds and have prompted the need for PFC monitoring and risk assignment This application note demonstrates a highly effective accurate and reproducible analysis of six PFCs in human breast milk

Sensitive and accurate Quantitation of perflurinated compounds in Human Breast Milk using selected Reaction monitoring assays by LCMSMS

bull To overcome Vit D deficiency fortification of vitamin D in some dietary sources becomes necessary The intake of excessive amounts of vitamin D can however lead to a potentially dangerous condition In this application note we describe an accessible and comprehensive LC-MSMS method to measure vitamin D levels in infant formula

bull Cowrsquos milk is one of the most common causes of allergic reactions in early life Milk contains approximately three p protein about 80of the milk proteins are caseins The casein fraction is composed of alphaS1-alphaS2-beta- and k-casein of which alpha S1-casein seems to be a significant allergen LC-MSMS methods were developed for milk allergen identification and quantitation in wine using high resolutionaccurate mass and linear ion trap mass spectrometers

Multi-residue Automated Turbulent Flow Online LC-MSMS Method for the Determination of Antibiotics in Milk

Analysis of Plasticizer Contaminants in Beverages and Milk using an Automated System Based on Turbulent-flow Chromatography Coupled to LC-MSMS

Milk Allergen Identification and Quantitation in Wine with LC-MSMS Approaches

Measurement of Vitamin D in Infant Formulas Using Automated Online Sample Preparation with Liquid ChromatographyTandem Mass Spectrometry

Simple and Rapid Analysis of Chloramphenicol in Milk by LC-MSMS

Page 4: Chemical analysis of nutrients and contaminants to ensure ......2 There are various ways in which the milk and milk products we consume might become unhealthy. Therefore, quality control

4

bull Breast milk is the primary source of nutrition for newborns before they can eat and digest other foods The proteins vitamins and ionic elements such as sodium potassium calcium magnesium chloride and nitrate present in breast milk are essential for infant health By monitoring the concentrations of these ions in breast milk the maternal diet can be adjusted to improve milk quality IC is an efficient means to determine anions even in samples with complex matrixes

bull To meet the demands of the Lactose -intolerant population lactose-free products are commercially produced by enzymatic hydrolysis with lactase 1 However the enzymatic hydrolysis process is not 100 efficient Therefore commercial suppliers need accurate and robust methods to determine lactose concentrations in milk products and residual Lactose is lactose-free products The Application note demonstrate fast separations of Lactose and lactulose in food samples by HPAE-PAD

bull Lactose intolerant individuals use commercially available Lactose-free milk products but these products also contain varying amounts of residual Lactose This application note here describes a sensitive and accurate method to determine Lactose and lactulose in dairy products including lactose-free products using high-performance anion-exchange chromatography with pulsed amperometric detection (HPAE-PAD)

Ion Chromatography

Determination of Lactose is Lactose-Free Milk Products by High-Performance Anion-Exchange Chromatography with Pulsed Amperometric Detection

bull Dicyandiamide is used by farmers to minimize the environmental impact of livestock on land it is also used to make the protein content of food appear higher (ie protein adulteration) Overuse of dicyandiamide can lead to its appearance in dairy products Both reversed-phase HPLC and liquid chromatography-tandem mass spectrometry (LC-MSMS) has been used to quantify dicyandiamide in various matrices

Determination of Dicyandiamide in Milk Powder

Fast Determinations of Lactose and Lactulose in Milk Products Using HPAE-PAD

Determination of Anions in Breast Milk

5

bull Melamine is a nitrogen-rich compound it has been used to fraudulently increase the detected protein level in milk so that the milk can command a higher price The ingestion of Melamine can cause renal complications including kidney and bladder stones and even bladder cancer This application note describes a method of testing infant formula milk for the presence of Melamine

bull Synthetic glucocorticoids are administered to livestock to treat inflammatory diseases and other diseases common to farm animals The presence of glucocorticoid residues in animal-derived food may be harmful to humans The application note helps understand an effective LC-MSMS method to detect eight glucocorticoid residues

bull Apart from the high source of calcium and potassium milk contains several essential elements such as iron copper and zinc Analysis of milk can determine whether milk is meeting the expected nutritional requirements or is lacking alternatively the analysis of trace elements that are toxic in nature can alert us to the possible risk of contamination in milk The application note offers total elemental determinations including iodine for milk and milk products

Liquid Chromatography with Tandem Mass Spectrometry (LC-MSMS)

Inductively Coupled Plasma Mass Spectrometry ICPMS

Detection of Glucocorticoid Residues in Animal-derived Food by HPLC-MSMS Determination of Melamine in Powdered

Milk by LC-MSMS Using a Core Enhanced Technology Solid Core HPLC Column

The Determination of Major and Trace Elements in Milk using ICP-Q-MS

Find out more at thermofishercomfurlFor Research Use Only Not for use in diagnostic procedures copy 2019 Thermo Fisher Scientific Inc All rights reserved All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified ThermofisherIndiaCM_27072020

bull Chloramphenicol (CAP) is a broad-spectrum antibiotic with historical veterinary uses in all significant food-producing animals It has a serious side effects on humans that may cause aplastic anemia and the suspected carcinogen effect This technical note shows a simple rapid and sensitive LC-MSMS method for analyzing chloramphenicol in milk

bull Antibiotics are widely used in animal husbandry primarily for the protection of animals from disease but also as growth promoters The use of LC-MSMS for screening was described in a validated multi-residue screening method to monitor 58 antibiotics in milk This application note describes a multi-residue confirmatory method for the quantitative determination of antibiotics in milk using turbulent flow chromatography coupled to LC-MSMS

bull Phthalates the endocrine active chemicals have been used to adulterate beverages and sports drinks in Taiwan deliberately and phthalates and other plasticizers are widely found as ubiquitous contaminants particularly in fatty foodstuffs This application note describes a method that has been validated for 11 plasticizers in beverages and milk

bull Bioaccumulation of perfluorinated compounds(PFCs) in wildlife and humans have led to efforts to regulate these compounds and have prompted the need for PFC monitoring and risk assignment This application note demonstrates a highly effective accurate and reproducible analysis of six PFCs in human breast milk

Sensitive and accurate Quantitation of perflurinated compounds in Human Breast Milk using selected Reaction monitoring assays by LCMSMS

bull To overcome Vit D deficiency fortification of vitamin D in some dietary sources becomes necessary The intake of excessive amounts of vitamin D can however lead to a potentially dangerous condition In this application note we describe an accessible and comprehensive LC-MSMS method to measure vitamin D levels in infant formula

bull Cowrsquos milk is one of the most common causes of allergic reactions in early life Milk contains approximately three p protein about 80of the milk proteins are caseins The casein fraction is composed of alphaS1-alphaS2-beta- and k-casein of which alpha S1-casein seems to be a significant allergen LC-MSMS methods were developed for milk allergen identification and quantitation in wine using high resolutionaccurate mass and linear ion trap mass spectrometers

Multi-residue Automated Turbulent Flow Online LC-MSMS Method for the Determination of Antibiotics in Milk

Analysis of Plasticizer Contaminants in Beverages and Milk using an Automated System Based on Turbulent-flow Chromatography Coupled to LC-MSMS

Milk Allergen Identification and Quantitation in Wine with LC-MSMS Approaches

Measurement of Vitamin D in Infant Formulas Using Automated Online Sample Preparation with Liquid ChromatographyTandem Mass Spectrometry

Simple and Rapid Analysis of Chloramphenicol in Milk by LC-MSMS

Page 5: Chemical analysis of nutrients and contaminants to ensure ......2 There are various ways in which the milk and milk products we consume might become unhealthy. Therefore, quality control

5

bull Melamine is a nitrogen-rich compound it has been used to fraudulently increase the detected protein level in milk so that the milk can command a higher price The ingestion of Melamine can cause renal complications including kidney and bladder stones and even bladder cancer This application note describes a method of testing infant formula milk for the presence of Melamine

bull Synthetic glucocorticoids are administered to livestock to treat inflammatory diseases and other diseases common to farm animals The presence of glucocorticoid residues in animal-derived food may be harmful to humans The application note helps understand an effective LC-MSMS method to detect eight glucocorticoid residues

bull Apart from the high source of calcium and potassium milk contains several essential elements such as iron copper and zinc Analysis of milk can determine whether milk is meeting the expected nutritional requirements or is lacking alternatively the analysis of trace elements that are toxic in nature can alert us to the possible risk of contamination in milk The application note offers total elemental determinations including iodine for milk and milk products

Liquid Chromatography with Tandem Mass Spectrometry (LC-MSMS)

Inductively Coupled Plasma Mass Spectrometry ICPMS

Detection of Glucocorticoid Residues in Animal-derived Food by HPLC-MSMS Determination of Melamine in Powdered

Milk by LC-MSMS Using a Core Enhanced Technology Solid Core HPLC Column

The Determination of Major and Trace Elements in Milk using ICP-Q-MS

Find out more at thermofishercomfurlFor Research Use Only Not for use in diagnostic procedures copy 2019 Thermo Fisher Scientific Inc All rights reserved All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified ThermofisherIndiaCM_27072020

bull Chloramphenicol (CAP) is a broad-spectrum antibiotic with historical veterinary uses in all significant food-producing animals It has a serious side effects on humans that may cause aplastic anemia and the suspected carcinogen effect This technical note shows a simple rapid and sensitive LC-MSMS method for analyzing chloramphenicol in milk

bull Antibiotics are widely used in animal husbandry primarily for the protection of animals from disease but also as growth promoters The use of LC-MSMS for screening was described in a validated multi-residue screening method to monitor 58 antibiotics in milk This application note describes a multi-residue confirmatory method for the quantitative determination of antibiotics in milk using turbulent flow chromatography coupled to LC-MSMS

bull Phthalates the endocrine active chemicals have been used to adulterate beverages and sports drinks in Taiwan deliberately and phthalates and other plasticizers are widely found as ubiquitous contaminants particularly in fatty foodstuffs This application note describes a method that has been validated for 11 plasticizers in beverages and milk

bull Bioaccumulation of perfluorinated compounds(PFCs) in wildlife and humans have led to efforts to regulate these compounds and have prompted the need for PFC monitoring and risk assignment This application note demonstrates a highly effective accurate and reproducible analysis of six PFCs in human breast milk

Sensitive and accurate Quantitation of perflurinated compounds in Human Breast Milk using selected Reaction monitoring assays by LCMSMS

bull To overcome Vit D deficiency fortification of vitamin D in some dietary sources becomes necessary The intake of excessive amounts of vitamin D can however lead to a potentially dangerous condition In this application note we describe an accessible and comprehensive LC-MSMS method to measure vitamin D levels in infant formula

bull Cowrsquos milk is one of the most common causes of allergic reactions in early life Milk contains approximately three p protein about 80of the milk proteins are caseins The casein fraction is composed of alphaS1-alphaS2-beta- and k-casein of which alpha S1-casein seems to be a significant allergen LC-MSMS methods were developed for milk allergen identification and quantitation in wine using high resolutionaccurate mass and linear ion trap mass spectrometers

Multi-residue Automated Turbulent Flow Online LC-MSMS Method for the Determination of Antibiotics in Milk

Analysis of Plasticizer Contaminants in Beverages and Milk using an Automated System Based on Turbulent-flow Chromatography Coupled to LC-MSMS

Milk Allergen Identification and Quantitation in Wine with LC-MSMS Approaches

Measurement of Vitamin D in Infant Formulas Using Automated Online Sample Preparation with Liquid ChromatographyTandem Mass Spectrometry

Simple and Rapid Analysis of Chloramphenicol in Milk by LC-MSMS

Page 6: Chemical analysis of nutrients and contaminants to ensure ......2 There are various ways in which the milk and milk products we consume might become unhealthy. Therefore, quality control

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bull Chloramphenicol (CAP) is a broad-spectrum antibiotic with historical veterinary uses in all significant food-producing animals It has a serious side effects on humans that may cause aplastic anemia and the suspected carcinogen effect This technical note shows a simple rapid and sensitive LC-MSMS method for analyzing chloramphenicol in milk

bull Antibiotics are widely used in animal husbandry primarily for the protection of animals from disease but also as growth promoters The use of LC-MSMS for screening was described in a validated multi-residue screening method to monitor 58 antibiotics in milk This application note describes a multi-residue confirmatory method for the quantitative determination of antibiotics in milk using turbulent flow chromatography coupled to LC-MSMS

bull Phthalates the endocrine active chemicals have been used to adulterate beverages and sports drinks in Taiwan deliberately and phthalates and other plasticizers are widely found as ubiquitous contaminants particularly in fatty foodstuffs This application note describes a method that has been validated for 11 plasticizers in beverages and milk

bull Bioaccumulation of perfluorinated compounds(PFCs) in wildlife and humans have led to efforts to regulate these compounds and have prompted the need for PFC monitoring and risk assignment This application note demonstrates a highly effective accurate and reproducible analysis of six PFCs in human breast milk

Sensitive and accurate Quantitation of perflurinated compounds in Human Breast Milk using selected Reaction monitoring assays by LCMSMS

bull To overcome Vit D deficiency fortification of vitamin D in some dietary sources becomes necessary The intake of excessive amounts of vitamin D can however lead to a potentially dangerous condition In this application note we describe an accessible and comprehensive LC-MSMS method to measure vitamin D levels in infant formula

bull Cowrsquos milk is one of the most common causes of allergic reactions in early life Milk contains approximately three p protein about 80of the milk proteins are caseins The casein fraction is composed of alphaS1-alphaS2-beta- and k-casein of which alpha S1-casein seems to be a significant allergen LC-MSMS methods were developed for milk allergen identification and quantitation in wine using high resolutionaccurate mass and linear ion trap mass spectrometers

Multi-residue Automated Turbulent Flow Online LC-MSMS Method for the Determination of Antibiotics in Milk

Analysis of Plasticizer Contaminants in Beverages and Milk using an Automated System Based on Turbulent-flow Chromatography Coupled to LC-MSMS

Milk Allergen Identification and Quantitation in Wine with LC-MSMS Approaches

Measurement of Vitamin D in Infant Formulas Using Automated Online Sample Preparation with Liquid ChromatographyTandem Mass Spectrometry

Simple and Rapid Analysis of Chloramphenicol in Milk by LC-MSMS