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Carboxylic acid estersQ 0530 Alkoxycarbonylation of Aryl Iodides Catalyzed by Pd with a Thiourea Type

Ligand under Balloon Pressure of CO. — The method tolerates various functional groups at the aromatic ring. Best results are achieved using triethylamine as base, albeit long reaction times are required and the mixture must be heated at 70 °C. In contrast, using sodium ethoxide, catalyst loading can be lowered and the reaction is completed within 2 hours. However, the products are obtained with only moderate yields with ex-ception of (IV). — (LIU, J.; LIANG, B.; SHU, D.; HU, Y.; YANG*, Z.; LEI, A.; Tetrahedron 64 (2008) 40, 9581-9584; Key Lab. Bioorg. Chem. Mol. Eng., Minist. Educ., Coll. Chem., Peking Univ., Beijing 100871, Peop. Rep. China; Eng.) —S. Adam

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